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4 results on '"Małgorzata Mirr"'

1. Serum Asprosin Correlates with Indirect Insulin Resistance Indices

Author

Małgorzata Mirr, Anna Braszak-Cymerman, Aleksandra Ludziejewska, Matylda Kręgielska-Narożna, Paweł Bogdański, Wiesław Bryl, and Maciej Owecki

Subjects
asprosin, adipokine, obesity, insulin resistance, Biology (General), QH301-705.5
Abstract

Background and Objectives: Insulin resistance is a major contributor to the development of type 2 diabetes and can be assessed using indirect indicators calculated from non-invasive tests. Asprosin is a recently discovered adipokine with a postulated effect on glycemic regulation. This study aimed to investigate the correlation between serum asprosin levels and insulin resistance indices. The correlation between circulating asprosin and obesity indices was also investigated. Materials and Methods: A total of 50 non-diabetic patients with obesity and 50 healthy volunteers were studied. Laboratory data, including circulating asprosin and anthropometric data, were collected. The following insulin resistance indices were calculated: triglyceride–glucose index (TyG), TyG–neck circumference (TyG–NC), TyG–neck circumference to height ratio (TyG–NHtR), TyG–waist circumference (TyG–WC), TyG–waist to height ratio (TyG–WHtR), TyG–body mass index (TyG–BMI), and the ratio between triglycerides and high-density cholesterol (TG/HDLc). The obtained data were analyzed separately for males and females. Results: Asprosin concentrations were significantly higher in obese patients (p < 0.001). Asprosin concentrations positively correlated with body mass index (p < 0.001, r = 0.8 in females and r = 0.8 in males), waist circumference (p < 0.001, r = 0.73 in females and r = 0.81 in males), and all tested indices of insulin resistance. The strongest correlation was observed for TyG–BMI (p < 0.001, r = 0.78 in females and r = 0.81 in males). Circulating asprosin was higher in females (p < 0.001). Conclusions: Asprosin can be considered a marker of obesity and insulin resistance.

Published
2023
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2. An Update to the WISP-1/CCN4 Role in Obesity, Insulin Resistance and Diabetes

Author

Małgorzata Mirr and Maciej Owecki

Subjects
CCN4 protein, human, insulin resistance, obesity, diabetes mellitus, type 2, Medicine (General), R5-920
Abstract

Insulin resistance refers to the diminished response of peripheral tissues to insulin and is considered the major risk factor for type 2 diabetes. Although many possible mechanisms have been reported to develop insulin resistance, the exact underlying processes remain unclear. In recent years, the role of adipose tissue as a highly active metabolic and endocrine organ, producing proteins called adipokines and their multidirectional activities has gained interest. The physiological effects of adipokines include energy homeostasis and insulin sensitivity regulation. In addition, an excess of adipose tissue is followed by proinflammatory state which results in dysregulation of secreted cytokines contributing to insulin resistance. Wingless-type (Wnt) inducible signalling pathway protein-1 (WISP-1), also known as CCN4, has recently been described as a novel adipokine, whose circulating levels are elevated in obese and insulin resistant individuals. Growing evidence suggests that WISP-1 may participate in the impaired glucose homeostasis. In this review, we characterize WISP-1 and summarize the latest reports on the role of WISP-1 in obesity, insulin resistance and type 2 diabetes.

Published
2021
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3. Newly proposed insulin resistance indexes called TyG-NC and TyG-NHtR show efficacy in diagnosing the metabolic syndrome

Author

Damian Skrypnik, Maciej Owecki, Paweł Bogdański, and Małgorzata Mirr

Subjects
Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, 030204 cardiovascular system & hematology, Overweight, Gastroenterology, Body Mass Index, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Insulin resistance, Internal medicine, medicine, Humans, Obesity, Triglycerides, Metabolic Syndrome, Receiver operating characteristic, Anthropometry, business.industry, Cholesterol, HDL, Area under the curve, Reproducibility of Results, Blood Pressure Determination, Middle Aged, medicine.disease, ROC Curve, Area Under Curve, Female, Original Article, Metabolic syndrome, medicine.symptom, business, Body mass index, Biomarkers
Abstract

Purpose Obesity and insulin resistance are considered cardinal to the pathophysiology of metabolic syndrome. Several simple indexes of insulin resistance calculated from biochemical or anthropometric variables have been proposed. The study aimed to assess the diagnostic accuracy of indirect insulin resistance indicators in detecting metabolic syndrome in non-diabetic patients, including TG/HDLc, METS-IR, TyG, TyG-BMI, TyG-WC, TyG-WHtR, and new indicators TyG-NC (TyG-neck circumference) and TyG-NHtR (Tyg-neck circumference to height ratio). Methods The diagnostic accuracy of eight insulin resistance indexes was assessed using the receiver operating characteristic curves (ROC curves) in 665 adult non-diabetic patients. Then, the analysis was performed after the division into groups with proper body mass index, overweight and obese. Results All indexes achieved significant diagnostic accuracy, with the highest AUC (area under the curve) for TyG (0.888) and Tg/HDLc (0.874). The highest diagnostic performance in group with the proper body mass index was shown for TyG (0.909) and TyG-BMI (0.879). The highest accuracy in the group of overweight individuals was presented by TyG (0.884) and TG/HDLc (0.855). TG/HDLc and TyG showed the highest AUC (0.880 and 0.877, respectively) in the group with obesity. Both TyG-NC and TyG-NHtR reached significant areas under the curve, which makes them useful diagnostic tests in metabolic syndrome. Conclusions Indirect indices of insulin resistance, including proposed TyG-NC and TyG-NHtR, show an essential diagnostic value in diagnosing metabolic syndrome. TyG and TG/HDLc seem to be the most useful in the Caucasian population.

Published
2021

4. Effect of sleep duration on blood pressure in women over 55 years of age - Poznan Cohort study

Author

Remigiusz, Domin, Karolina, Owsik, Urszula, Szybowicz, Katarzyna, Sochacka, Małgorzata, Mirr, Maciej, Spałek, Damian, Skrypnik, Paweł, Bogdański, and Maciej, Owecki

Subjects
Cohort Studies, Cross-Sectional Studies, Hypertension, Humans, Blood Pressure, Female, Middle Aged, Sleep
Abstract

Hypertension is considered to be the most common pathology of the circulatory system and the most common cause of death or cardiovascular diseases' development. There are many commonly known risk factors of this condition, such as overweight, obesity, a high-fat diet, family history of ischemic heart disease, lipid disorders, and atherosclerosis. In order to reduce the effect of high blood pressure, patients should modify their lifestyle, including sleeping patterns. We wanted to investigate if, in a group of women over 55 years of age compared to the general population from Poznan cohort, sleep duration is related to hypertension.All subjects were divided into three research groups depending on the time of sleep. The first group included people who have been sleeping less than 6 hours a day. The second group included people who have been sleeping from 6 to 9 hours a day. The third group was characterized by people with sleep time over 9 hours a day. Due to their age, participants were divided into two groups, below and over 55 years of age.There is a weak positive correlation between long sleep duration (9h) and a higher prevalence of unregulated blood pressure (r = 0.3, p = 0.017) in the group of women over 55 years of age.Unregulated increased blood pressure may occur more frequently in postmenopausal women whose sleep duration exceeds 9 hours a day.

Published
2020

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