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The purpose of the work was to reveal the informativeness of the factor of hereditary aggravation for prognosis of atherosclerosis of the aorta and cardiac vessels under conditions of mass preventive surveys. It was accomplished by the method of point evaluation of hereditary aggravation based on the distribution of the common genes in relatives of various kinship according to Galton's law of regression. It was found that the presence in relatives of first and second degree kinship of angina pectoris, myocardial infarction, hypertensive disease, stroke, diabetes mellitus, obesity and also cases of sudden death among them allow the appearance of atherosclerosis of the cardiac vessels and aorta to be prognosed both in the age and the clinical aspect.