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Additional file 1: Table A1. Thirty-nine components of Solanum nigrum and their corresponding molecular weight (MW), predicted oral bioavailability (OB) and drug likeness (DL) scores. Table A2. Bladder cancer (BC) related targets in Solanum nigrum. By combining the related targets of active ingredients screened from S. nigrum and the disease-related targets, 100 overlapping targets (involving 23 duplicates) were selected as the key targets involved in the treatment of BC. Table A3. Gene ontology (GO) terms of therapeutic target genes and their corresponding counts, p-value, and FDR. Through the GO enrichment of the key targets, 86 remarkably enriched (p-value ≤0.01) GO terms were obtained, indicating that some targets were involved in tumorigenesis. Table A4. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway of therapeutic target genes and their corresponding counts, p-value, and FDR. Through KEGG enrichment of the key targets, 89 remarkably enriched (p-value ≤0.01) pathways were obtained, indicating that numerous targets are involved in the processes of tumorigenesis and tumor progression.

Additional file 1.

This paper introduces the developing direction of power systems in future naval vessels, and summarizes the characters of present shipboard construction and protection. In order to find the most suitable protection scheme for future complicated systems, a ladder-shaped shipboard with multiple stations was simulated with software PSCAD/EMTDC. For comparison purposes, this paper discusses both the traditional shipboard power system protection and the longitudinal differential protection which is common in a land-based power system. It also analyzes how these protections work in different modes when a three-phase fault happens in different places at different time. A vector of the breakerspsila state is used to describe the changes of topology. From the simulation, the benefits and drawbacks of these protections used in such a system are spread out. This paper will give some suggestions for future researches on the shipboard power system protection.

Aiming at the power supply quality of 500 kV large power compact transmission lines, their transmission ability is discussed in detail when different kinds of conductor bundle are used. Based on this discussion, the best model and number of subconductors are also put forward in this paper which points out that 500 kV large power compact overhead transmission lines will contribute to tremendous economic gains in the Three Gorges power station project. >

A local geoid model to predict the geoid heights in the vicinity of Monterey Bay, California, was developed to use Global Positioning System (GPS) differential positions and known Mean Sea Level (MSL) with the method of collocation. The local geoid models were based on Rapp's 360 degree x 360 order global geoid model determined from gravity measurements. Control data were adjusted by least squares to solve for the parameters in the local geoid model. Also studied were factors that affected the GPS-measured ellipsoid height differences. These included (1) comparing GPS differencing solutions, (2) standard error of GPS observations, (3) corrections for surface meteorological values, and (4) observation durations for GPS. The data used in this research were taken from GPS measurements on the campus of the Naval Postgraduate School (NPS), an area about 100 m x 630 m and in an area approximately 15 km x 33 km near Monterey, California. The time period was from February 5, 1988, to May 12, 1988. The accuracy of the predicted geoid heights is ± 2 cm if a six-parameter model is used for the large area, and ± 2 to 10 mm if a five-parameter model is used for the NPS campus. http://archive.org/details/localgeoiddeterm1094523288 Lieutenant, Republic of China Navy Approved for public release; distribution is unlimited.