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1. Asymmetric syntheses of fused bicyclic lactams

3. Discovery of XL888: A novel tropane-derived small molecule inhibitor of HSP90

4. Discovery of a Novel Class of Highly Potent, Selective, ATP-Competitive, and Orally Bioavailable Inhibitors of the Mammalian Target of Rapamycin (mTOR)

5. Discovery of a Novel Series of Potent and Orally Bioavailable Phosphoinositide 3-Kinase γ Inhibitors

10. Discovery of a Novel Classof Highly Potent, Selective,ATP-Competitive, and Orally Bioavailable Inhibitors of the MammalianTarget of Rapamycin (mTOR).

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