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This study explores the compelling antitumor properties of VALD‐2, a synthetic Schiff base ligand known for its low toxicity. The focus is on investigating VALD‐2's protective role against cisplatin‐induced acute kidney injury (AKI) in mice, with a specific emphasis on mitigating oxidative stress and inflammation. The study involves daily intraperitoneal injections of amifostine or VALD‐2 over 7 days to establish an AKI model. Subsequently, mice were assigned to normal control, cisplatin group, cisplatin + amifostine group, and cisplatin + VALD‐2 10 mg/kg group, cisplatin + VALD‐2 20 mg/kg, and cisplatin + VALD‐2 40 mg/kg. Kidney injury is assessed through serum blood urea nitrogen (BUN) and creatinine (Cr) activity assays. Levels of inflammatory factors, tumor necrosis factor‐α (TNF‐α) and interleukin‐6 (IL‐6), in kidney tissue of mice were assessed through enzyme‐linked immunosorbent assay (ELISA). The protective effect of VALD‐2 is further examined through HE staining to observe pathological changes in kidney injury. The ultrastructural changes of renal cells and tubular epithelial cells were observed by electron microscopy under experimental conditions, indicating the effect of VALD‐2 on reversing cisplatin‐induced renal injury. The study delves into VALD‐2's protective mechanisms against cisplatin‐induced kidney injury by using western blot analysis to assess the expression levels of superoxide dismutase (SOD), glutathione peroxidase (GSH‐Px), and malondialdehyde (MDA) in kidney tissues. VALD‐2 demonstrates significant improvement in cisplatin‐induced AKI, as evidenced by increased BUN and Cr levels. It effectively protects kidney tissue from oxidative damage, enhancing SOD and GSH‐Px activities while reducing MDA levels. The study also reveals a decrease in TNF‐α and IL‐6 levels, supported by ELISA results, and histological findings confirm anti‐nephrotoxic effects. Western blot analysis shows an upregulation of antioxidant enzymes (SOD, GSH‐Px) and a reduction in MDA production. VALD‐2 emerges as a promising mitigator of cisplatin‐induced AKI, showcasing its ability to enhance oxidative stress‐related protein expression. The findings suggest VALD‐2 as a potential therapeutic agent for protecting against cisplatin‐induced kidney injury. Highlights: VALD‐2 is a yellow precipitate, a Schiff base ligand synthesized by mixing diethylene‐triamine and o‐vanillin and insoluble in 0.9% sodium chloride. It has been also reported that which forms complexes with most metals and has potential antibacterial, antiviral, and anticancer effects.In our previous study, we found that VALD showed antitumor effects both in vivo and in vitro. In recent years, the antitumor activities of some Schiff base ligands have been widely reported.Our study revealed for the first time that VALD‐2 alleviates cisplatin‐induced acute renal injury by inhibiting renal inflammation and enhancing the endogenous antioxidant system, which provides a molecular basis for the new drug treatment of cisplatin‐induced acute renal injury. [ABSTRACT FROM AUTHOR]

Cotton plays a crucial role in the progress of the textile industry and the betterment of human life by providing natural fibers. In our study, we explored the genetic determinants of cotton architecture and fiber yield and quality by crossbreeding Gossypium hirsutum and Gossypium barbadense, creating a recombinant inbred line (RIL) population. Utilizing SNP markers, we constructed an extensive genetic map encompassing 7,730 markers over 2,784.2 cM. We appraised two architectural and seven fiber traits within six environments, identifying 58 QTLs, of which 49 demonstrated stability across these environments. These encompassed QTLs for traits such as lint percentage (LP), boll weight (BW), fiber strength (STRENGTH), seed index (SI), and micronaire (MIC), primarily located on chromosomes chr‐A07, chr‐D06, and chr‐D07. Notably, chr‐D07 houses a QTL region affecting SI, corroborated by multiple studies. Within this region, the genes BZIP043 and SEP2 were identified as pivotal, with SEP2 particularly showing augmented expression in developing ovules. These discoveries contribute significantly to marker‐assisted selection, potentially elevating both the yield and quality of cotton fiber production. These findings provide valuable insights into marker‐assisted breeding strategies, offering crucial information to enhance fiber yield and quality in cotton production. [ABSTRACT FROM AUTHOR]

Summary: This paper considers the event‐triggered H∞ control problem of nonlinear switched singular systems (NSSSs) with incremental quadratic constraints (IQCs) via a mode‐dependent hybrid triggering strategy. First, impulsive control is introduced to reduce the effect of impulse caused by switching, and the closed‐loop system is modeled as an impulsive NSSS. Then, a novel mode‐dependent hybrid event‐triggering strategy (ETS) consisting of disturbance‐influenced ETS and Lyapunov‐function‐dependent ETS is constructed to avoid Zeno behavior and asynchronous phenomena. Based on this ETS and admissible edge‐dependent average dwell time (AED‐ADT) method, some new sufficient conditions in terms of linear matrix inequalities (LMIs) are derived to ensure that the closed‐loop system is regular, impulse‐free, has a unique solution, and is globally uniformly asymptotically stable (GUAS) with a weighted H∞ performance. Further, Zeno behavior is excluded by calculating the minimum lower bound of inter‐event time. Finally, a numerical example and a practical application are proposed to demonstrate the validity of the results. [ABSTRACT FROM AUTHOR]