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165 results on '"Ma, S.‐H."'

7. Cost-Effectiveness of Monitoring Patients Post-Stroke With Mobile ECG During the Hospital Stay

Author

Gao, L, Moodie, M, Freedman, B, Lam, C, Tu, H, Swift, C, Ma, S-H, Mok, VCT, Sui, Y, Sharpe, D, Ghia, D, Jannes, J, Davis, S, Liu, X, Yan, B, Gao, L, Moodie, M, Freedman, B, Lam, C, Tu, H, Swift, C, Ma, S-H, Mok, VCT, Sui, Y, Sharpe, D, Ghia, D, Jannes, J, Davis, S, Liu, X, and Yan, B

Abstract

Background The effectiveness of a nurse-led in-hospital monitoring protocol with mobile ECG (iECG) was investigated for detecting atrial fibrillation in patients post-ischemic stroke or post-transient ischemic attack. The study aimed to assess the cost-effectiveness of using iECG during the initial hospital stay compared with standard 24-hour Holter monitoring. Methods and Results A Markov microsimulation model was constructed to simulate the lifetime health outcomes and costs. The rate of atrial fibrillation detection in iECG and Holter monitoring during the in-hospital phase and characteristics of modeled population (ie, age, sex, CHA2DS2-VASc) were informed by patient-level data. Costs related to recurrent stroke, stroke management, medications (new oral anticoagulants), and rehabilitation were included. The cost-effectiveness analysis outcome was calculated as an incremental cost per quality-adjusted life-year gained. As results, monitoring patients with iECG post-stroke during the index hospitalization was associated with marginally higher costs (A$31 196) and greater benefits (6.70 quality-adjusted life-years) compared with 24-hour Holter surveillance (A$31 095 and 6.66 quality-adjusted life-years) over a 20-year time horizon, with an incremental cost-effectiveness ratio of $3013/ quality-adjusted life-years. Monitoring patients with iECG also contributed to lower recurrence of stroke and stroke-related deaths (140 recurrent strokes and 20 deaths avoided per 10 000 patients). The probabilistic sensitivity analyses suggested iECG is highly likely to be a cost-effective intervention (100% probability). Conclusions A nurse-led iECG monitoring protocol during the acute hospital stay was found to improve the rate of atrial fibrillation detection and contributed to slightly increased costs and improved health outcomes. Using iECG to monitor patients post-stroke during initial hospitalization is recommended to complement routine care.

Published
2022

34. Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation

Author

Zhu, H. G., Bai, F., Zhang, J. Y., Ye, D., Liu, J., Xu, Z. D., Ma, S. H., Guan, K. L., Xiong, Y., Yang, H., Ling, Z. Q., and Liu, Y.

Abstract

The TET (ten–eleven translocation) family of α-ketoglutarate (α-KG)-dependent dioxygenases catalyzes the sequential oxidation of 5-methylcytosine (5mC) to 5-hydroxymethyl-cytosine (5hmC), 5-formylcytosine and 5-carboxylcytosine, leading to eventual DNA demethylation. The TET2 gene is a bona fide tumor suppressor frequently mutated in leukemia, and TET enzyme activity is inhibited in IDH1/2-mutated tumors by the oncometabolite 2-hydroxyglutarate, an antagonist of α-KG, linking 5mC oxidation to cancer development. We report here that the levels of 5hmC are dramatically reduced in human breast, liver, lung, pancreatic and prostate cancers when compared with the matched surrounding normal tissues. Associated with the 5hmC decrease is the substantial reduction of the expression of all three TET genes, revealing a possible mechanism for the reduced 5hmC in cancer cells. The decrease of 5hmC was also observed during tumor development in different genetically engineered mouse models. Together, our results identify 5hmC as a biomarker whose decrease is broadly and tightly associated with tumor development.

Published
2013
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35. Abstract S3-04: ESR1 coregulator binding inhibitor (ECBI) as a novel therapeutic to target hormone therapy resistant metastatic breast cancer

Author

Vadlamudi, RK, primary, Sareddy, GR, additional, Viswanadhapalli, S, additional, Lee, T-K, additional, Ma, S-H, additional, Lee, WR, additional, Mann, M, additional, Krishnan, SR, additional, Gonugunta, V, additional, Strand, DW, additional, Tekmal, RR, additional, Ahn, J-M, additional, and Raj, GV, additional

Published
2016
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50. Structural, elastic, electronic, and optical properties of defect-chalcopyrite structure CdGa X ( X = S, Se) compounds.

Author

Ma, S.-H., Jiao, Z.-Y., and Zhang, X.-Z.

Subjects
OPTICAL properties, CHALCOPYRITE, ELECTRONIC structure, DIELECTRICS, ELECTRON energy states, REFLECTANCE, ANISOTROPY, REFRACTIVE index
Abstract

First-principles calculations were performed to investigate the elastic, electronic, and optical properties of defect-chalcopyrite (DC) structure CdGa X ( X = S, Se) compounds. The present calculations shown that the DC structure CdGa X ( X = S, Se) compounds are mechanically stable and have similar electronic structures. Optical properties including the dielectric function, optical reflectivity, refractive index and electron energy loss, are discussed for radiation up to 22 eV, and present calculations reveal a weak anisotropy in CdGaS and CdGaSe compounds. [ABSTRACT FROM AUTHOR]

Published
2012
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