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Introduction: Mitochondrial membrane potential (MMP) and mitochondrial mass (MM) affect mitochondrial function and lymphocyte activation, but few studies on HBV infection exist. This study aimed to investigate the regulatory mechanism of mitochondrial dysfunction during HBV infection and its clinical significance by analyzing the alterations of MM and MMPlow in peripheral blood immune cells. Methods: The study enrolled 90 participants, including healthy volunteers(HC) and patients with HBV infection, HBV patients were divided into chronic hepatitis B patients (CHB) and liver cirrhosis (LC) according to the study, and CHB was also divided into an inflammation group and a non-inflammation group. Flow cytometry was used to analyze the changes of MM and MMPlow in peripheral blood immune cells. These analyses were correlated with the presence of CHB and LC and indexes related to liver inflammation. Results: The study revealed significant variations in the percentage of MMPlow and MM of CD8+T cells associated with the progression of the disease. The MMPlow percentage of CD8+T cells in the LC group exhibited a notable decrease compared to the HC group and CHB groups. Moreover, MMPlow of CD8+T cells demonstrated potential in distinguishing CHB and LC (AUC=0.7341, P=0.0032). Furthermore, in exploring the link between mitochondrial function of immune cells and liver inflammation, the study found a negative correlation between the MMPlow ratio of CD4+T and CD8+T cells and AST (p=0.0039 and P=0.0070, r=-0.4405 and r=-0.4146), while the MM of CD8+T cells displayed a positive correlation with AST (p=0.0013, r=0.4865). In CHB patients with normal ALT but liver inflammation detected on B-scan ultrasonography, a significant decrease was observed in the MMPlow percentage of CD8+T (66.13 ± 14.27), CD56+NK(57.77 ± 17.40) and CD4-CD8-T (61.98 ± 15.98) cells. Furthermore, it was also found that the percentage of MMPlow in CD4-CD8-T cells could serve as an indicator for early liver inflammation and injury (AUC=0.8408, P=0.0052). Discussion: In this study, we conducted a systematic analysis of the percentage of lymphocyte MMPlow and MM in various stages of HBV infection. Our findings revealed a correlation between MMPlow and MM and early liver inflammation, as well as the progression of the infection. This study marked the first demonstration of the clinical diagnostic value of MMPlow and MM in HBV infection. Furthermore, this was the first study to discuss the mitochondria of lymphocytes and liver inflammation in HBV infection. It enhanced the understanding of the role of T cells in liver inflammation, and elucidated potential markers for the early detection of liver injury and clinical cirrhosis. [ABSTRACT FROM AUTHOR]

In this work, a reliable fault‐tolerant control scheme is proposed for open‐circuit faults of the drive in a three‐phase permanent magnet synchronous motor (PMSM) control system. A three‐phase four‐switch fault‐tolerant topology drive is employed to guarantee the continuous operation after fault occurrence. A non‐singular terminal sliding mode control (NTSMC) scheme is proposed to improve the robustness and the dynamic performance of the post‐fault system. To estimate the information of fault, a nonlinear learning fault observer is constructed. Based on the fault information, a compensation term is added to the control scheme against the adverse effects of the transition process. Simulation results show that the proposed fault‐tolerant control scheme enables the system to track the desired reference commands in the absence/presence of faults with satisfactory performance and achieves smooth transition for control law switching. [ABSTRACT FROM AUTHOR]

In this work, a fault tolerant control scheme is proposed for a class of nonlinear system with actuator faults. In this fault tolerant control strategy, an estimator is designed to estimate both the system states and the fault signal simultaneously. Based on these estimations, the control law is constructed to achieve the fault tolerant control for the nonlinear system considered. It is shown that the estimation error and the system state can be guaranteed to be bounded. The obtained theoretic results have been verified through the simulation examples on the three‐tank system. [ABSTRACT FROM AUTHOR]