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In the present work, two novel coordination polymers on the basis of Cu(II) are hydrothermally produced via utilizing 2,5‐dichloroterephthalic acid (H2DCTP), a halogenated linear ligand with the existence of diverse flexible nitrogen‐donor ligands of the 1,4‐bis(5,6‐dimethylbenzimidazol‐1‐yl)‐2‐butylene (L2) and the 1,1′‐(1,4‐butanediyl)bis‐1H‐benzimidazole (L1), and their chemical formulae are [Cu(L1)(DCTP)]n (1) and [Cu(L2)(DCTP)]n (2). The evaluation of two compounds' treatment effect against the thyroid cancer was carried out, and meanwhile, their relevant mechanism was also studied. First of all, the cancer cells proliferation was detected through Cell Counting Kit‐8 (CCK‐8) detection kit. Furthermore, the JAK‐STAT signalling pathway activation has been assessed through employing real time RT‐PCR assay. Finally, the toxicity of the new compounds was evaluated with MTT assay. [ABSTRACT FROM AUTHOR]

In the early period of the Qing Dynasty, the Nine Writers of the School of Yi Tang made a name for their works and personal integrity. Besides writing and teaching, they undertook to fight for their cause which is to make acquaintance of various persons as many as possible across the country, the adherents of the collapsed Ming Dynasty in particular. Due to the fact that the central and southern Jiangsu Province was a cultural centre of the then China, the Nine Writers of the Yitang School used to frequent this piece of land after the overthrow of the Ming Dynasty and therefore made many friends among those Jiangsu adherents of the Ming Dynasty, which resulted from their feeling towards the Ming Dynasty as well as their consciousness of saving the then society. Their emotions and thinking revealed a rich historical awareness and thus had a typical meaning in the early period of the Qing Dynasty. [ABSTRACT FROM AUTHOR]

Objective: To observe effect of subclinical hypothyroidism (SCH) on serum lipid level and expression of toll-like receptor 4 (TLR4) in rats' peripheral blood mononuclear cells (PBMC)., Methods: Fifty Wistar female rats were divided into three groups: normal control (NC group; n=10), sham group (n=10), and L-T-4 (L-thyroxine) group (n=30, with thyroidectomy, fed with rich-calcium water after operation. 5 weeks later, abdominal subcutaneous injection of L-T-4: 0.95 μg/100g/d). 8 weeks later, the rats were killed then the peripheral blood was collected to determine the levels of serum thyroid-stimulating hormone (TSH), total thyroid hormone (TT4), total cholesterol (TC) and low density lipoprotein cholesterin (LDL-C). Rats in L-T-4 group were divided into normal lipid (NL) group) and high lipid (HL) group) according to lipid value of NC group. Monocytes were separated from blood to determine TLR4 expression by flow cytometry., Results: In NL and HL groups TSH were higher than in NC and Sham groups (p<0.05). TT4 have no significant differences (p>0.05). TLR4, TLR4 mRNA, NF-κB (p65) were increased (p<0.05). TNF-α, IL-6 and IL-1β were higher than in NC and sham groups (p<0.01). There were no significant differences of TLR4, TLR4 mRNA, NF-κB (p65), TNF-α, IL-6 and IL-1β expression between NL and HL groups (p>0.05)., Conclusion: TLR4, TLR4 mRNA, NF-κB (p65) of PBMC and TNF-α, IL-6, IL-1β expression in serum were all increased in SCH rats, which was not related to serum dyslipidemia.

In the molecule of the the title compound, [Fe(C5H5)(C28H22F6N2PS)], the absolute configuration is R C ,SFe . The dihedral angle between the trifluoro-methyl-substituted phenyl ring and the thio-urea plane is 41.8 (9)°. The iron atom is bound to the cyclo-penta-dienyl rings in the typical η(5)-manner in a close to eclipsed conformation. The crystal structure features N-H⋯S hydrogen bonds, with the S atom as an acceptor for both N-H groups, forming a layered arrangement parallel to (1-10). The two -CF3 groups are each disordered over two positions with refined occupancy rates for the major components of 0.66 (7) and 0.55 (5). The crystal was grown from mixed solvents (n-hexane and ethyl acetate). These solvents are disordered in the crystal and the resulting electron density was found to be uninterpretable. The solvent contribution to the structure factors was taken into account by back-Fourier transformation of all density found in the disordered solvent area using the SQUEEZE routine in PLATON [Spek (2009 ▶). Acta Cryst. D65, 148-155]. The formula mass and density do not take account of the solvent.

Objective: To investigate the differences of clinical features, pulmonary function tests, chest imaging and prognosis between patients with idiopathic pulmonary fibrosis (IPF) combined with emphysema and without emphysema., Methods: Of the 117 patients diagnosed as IPF for the first time in the First Affiliated Hospital of China Medical University from January 2002 to January 2007, 23 cases met the diagnostic criteria for combined pulmonary fibrosis and emphysema (CPFE). Thirty-three cases with isolated IPF from 2002 to 2003 were selected as the control group. Clinical characteristics, pulmonary function indexes, PaO₂, bronchoalveolar lavage fluid (BALF) results and survival time were retrospectively analyzed and compared between the 2 groups., Results: The smoking indexes (pack-years)were significantly higher in the CPFE group (28 ± 18) compared with the IPF group (18 ± 16), t = 2.10, P < 0.05. No significant difference was observed between the 2 groups in terms of age, gender and the percentage of smokers. The CPFE group showed significantly lower FEV₁/FVC% [(77 ± 7)%, (83 ± 8)%, t = 3.55, P < 0.05] and D(L)CO% pred [(44 ± 12)%, (54 ± 16)%, t = 2.48, P < 0.05] compared to those of the IPF group, while TLC%pred was significantly higher in the CPFE group [(77 ± 11)%, (64 ± 12)%, t = 3.93, P < 0.05]. VC% pred and PaO₂ showed no significant difference between the 2 groups. The total cell count, the percentages of macrophages, neutrophils, lymphocytes and eosinophils in BALF showed no significant difference between the 2 groups. There was no significant difference in median survival time between the 2 groups., Conclusion: Smoking was an important risk factor for IPF combined with emphysema. The pulmonary function of IPF combined with emphysema is characterized by a mild abnormality in the lung volume but a significant decrease in the diffusing capacity. Combined emphysema has no influence on the survival time of patients with IPF.