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213 results on '"Ma, Jian-Ying"'

4. Identification of key programmed cell death genes for predicting prognosis and treatment sensitivity in colorectal cancer.

Author

Ma, Jian-ying, Wang, Yi-xian, Zhao, Zhen-yu, Xiong, Zhen-yu, Zhang, Zi-long, Cai, Jun, and Guo, Jia-wei

Subjects
CLUSTERING algorithms, TREATMENT effectiveness, APOPTOSIS, DISEASE risk factors, COLORECTAL cancer
Abstract

Colorectal cancer (CRC) ranks third in global incidence and second in mortality. However, a comprehensive predictive model for CRC prognosis, immunotherapy response, and drug sensitivity is still lacking. Various types of programmed cell death (PCD) are crucial for cancer occurrence, progression, and treatment, indicating their potential as valuable predictors. Fourteen PCD genes were collected and subjected to dimensionality reduction using regression methods to identify key hub genes. Predictive models were constructed and validated based on bulk transcriptomes and single-cell transcriptomes. Furthermore, the tumor microenvironment, immunotherapy response, and drug sensitivity profiles among patients with CRC were explored and stratified by risk. A risk score incorporating the PCD genes FABP4, AQP8, and NAT1 was developed and validated across four independent datasets. Patients with CRC who had a high-risk score exhibited a poorer prognosis. Unsupervised clustering algorithms were used to identify two molecular subtypes of CRC with distinct features. The risk score was combined with the clinical features to create a nomogram model with superior predictive performance. Additionally, patients with high-risk scores exhibited decreased immune cell infiltration, higher stromal scores, and reduced responsiveness to immunotherapy and first-line clinical drugs compared with low-risk patients. Furthermore, the top ten non-clinical first-line drugs for treating CRC were selected based on their predicted IC50 values. Our results indicate the efficacy of the model and its potential value in predicting prognosis, response to immunotherapy, and sensitivity to different drugs in patients with CRC. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Nitrogen Addition Increases the Sensitivity of Photosynthesis to Drought and Re-watering Differentially in C3 Versus C4 Grass Species

Author

Zhong, Shangzhi, Xu, Yueqiao, Meng, Bo, Loik, Michael E, Ma, Jian-Ying, and Sun, Wei

Subjects
Plant Biology, Biological Sciences, Ecology, extreme climate, N deposition, recovery extent and rate asymmetry, resistance, resilience, water pulse, Crop and pasture production, Plant biology
Abstract

Global change factors, such as variation in precipitation regimes and nitrogen (N) deposition, are likely to occur simultaneously and may have profound impacts on the relative abundance of grasses differing in functional traits, such as C3 and C4 species. We conducted an extreme drought and re-watering experiment to understand differences in the resistance and recovery abilities of C3 and C4 grasses under different N deposition scenarios. A C3 perennial grass (Leymus chinensis) and two C4 grasses (annual species Chloris virgata and perennial species Hemarthria altissima) that co-occur in Northeast China were selected as experimental plants. For both C3 and C4 grasses, N addition caused a strong increase in biomass and resulted in more severe drought stress, leading to a change in the dominant photosynthetic limitation during the drought periods. Although N addition increased antioxidant enzyme activities and protective solute concentrations, the carbon fixing capacity did not fully recover to pre-drought levels by the end of the re-watering period. N addition resulted in lower resilience under the drought conditions and lower resistance at the end of the re-watering. However, N addition led to faster recovery of photosynthesis, especially in the C3 grass, which indicate that the effect of N addition on photosynthesis during drought was asymmetric, especially in the plants with different photosynthetic nitrogen use efficiency (PNUE). These findings demonstrated that nitrogen deposition may significant alter the susceptibility of C3 and C4 grass species to drought stress and re-watering, highlighting the asymmetry between resistance and resilience and to improve our understanding about plant responses to climate change.

Published
2019

7. The Responses of Soil Nitrogen Transformations to Rainfall Reduction Mainly Occurred in the Early Growing‐Season in a Temperate Meadow

Author

Yang, Xuechen, primary, Sternberg, Marcelo, additional, Song, Wenzheng, additional, Zhong, Shangzhi, additional, Chai, Hua, additional, Li, Junqin, additional, Yao, Yuan, additional, Meng, Bo, additional, You, Mengyang, additional, Jiang, Qi, additional, Yue, Xiuquan, additional, Li, Lu‐Jun, additional, Ma, Jian‐Ying, additional, and Sun, Wei, additional

Published
2024
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13. Long-term in vivo study of biodegradable Zn-Cu stent: A 2-year implantation evaluation in porcine coronary artery

Author

Zhou, Chao, Li, Hua-Fang, Yin, Yu-Xia, Shi, Zhang-Zhi, Li, Ting, Feng, Xiang-Yi, Zhang, Jun-Wei, Song, Cai-Xia, Cui, Xiao-Shan, Xu, Kai-Li, Zhao, Yan-Wei, Hou, Wen-Bo, Lu, Shou-Tao, Liu, Guang, Li, Mao-Quan, Ma, Jian-ying, Toft, Egon, Volinsky, Alex A., Wan, Min, Yao, Xiu-jun, Wang, Chang-bin, Yao, Kang, Xu, Shi-kun, Lu, Hao, Chang, Shu-Fu, Ge, Jun-Bo, Wang, Lu-Ning, and Zhang, Hai-Jun

Published
2019
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50. The effects of mowing and multi-level N fertilization on soil bacterial and fungal communities in a semiarid grassland are year-dependent

Author

National Key Research and Development Program (China), National Natural Science Foundation of China, Fundamental Research Funds for the Central Universities (China), China Scholarship Council, European Commission, Ministerio de Ciencia e Innovación (España), Agencia Estatal de Investigación (España), Cui, Haiying [0000-0003-4993-2231], Sun, Wei [0000-0002-1601-2159], Delgado-Baquerizo, Manuel [0000-0002-6499-576X], Song, Wenzheng [0000-0002-1167-0291], Cui, Haiying, Sun, Wei, Delgado-Baquerizo, Manuel, Song, Wenzheng, Ma, Jian-Ying, Wang, Keying, Ling, Xiaoli, National Key Research and Development Program (China), National Natural Science Foundation of China, Fundamental Research Funds for the Central Universities (China), China Scholarship Council, European Commission, Ministerio de Ciencia e Innovación (España), Agencia Estatal de Investigación (España), Cui, Haiying [0000-0003-4993-2231], Sun, Wei [0000-0002-1601-2159], Delgado-Baquerizo, Manuel [0000-0002-6499-576X], Song, Wenzheng [0000-0002-1167-0291], Cui, Haiying, Sun, Wei, Delgado-Baquerizo, Manuel, Song, Wenzheng, Ma, Jian-Ying, Wang, Keying, and Ling, Xiaoli

Abstract

The diversity and structure of plant and soil microbial communities are influenced by temporal variability in environmental conditions (e.g., precipitation); however, it is unclear whether the responses of these biotic communities to land use practices (e.g., N fertilization and mowing) also vary over time. Here we investigated how harvesting hay by mowing and applications of N fertilization at different rates (0, 2.5, 5, 10, 20, and 40 g N m−2 yr−1) affected plant, bacterial, and fungal communities by exploring data collected from a field experiment in a semiarid grassland in northern China over two consecutive years of 2017 and 2018. The cumulative precipitation during the growing season differed between the two studied years. The sampling year had more effect on the structure of the plant and soil microbial community than N fertilization and mowing, suggesting that the effects of land use practices varied by year, and were difficult to predict over time. The diversity of bacteria and fungi showed a different response to N fertilization and mowing between the two years. For example, in the wet year, the fungal diversity was up to 11% lower in soil that had been treated using the highest N fertilizer application than in untreated soil, but showed little variation in the dry year. The bacterial diversity was higher for all N application rates in the mown than the unmown land during the wet year, but no difference was observed during the dry year. There were more opportunistic and sensitive taxa for the two years (over 36.9% of top 10% relative abundance of bacterial and fungal taxa) than for N fertilization and mowing (below 33.0% of top 10% relative abundance of bacterial and fungal taxa). The relationships between plant and soil microbial communities differed between the two years, and were much stronger in the dry year than the wet year. We conclude that N fertilization and mowing had varying effects on plant and soil microbial communities in the study area over

Published
2020

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