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In hypertrophic scars, the differentiation and migration of fibroblasts are influenced by the extracellular matrix microenvironment, which includes factors such as stiffness, restraint, and tensile force. These mechanical stresses incite alterations in cell behavior, accompanied by cytoskeletal protein reorganization. However, the role of nucleo-skeletal proteins in this context remains underexplored. In this study, we use a polyacrylamide hydrogel (PAA) to simulate the mechanical stress experienced by cells in scar tissue and investigate the impact of Emerin on cell behavior. We utilize atomic force microscopy (AFM) and RNA interference technology to analyze cell differentiation, migration, and stiffness. Our findings reveal that rigid substrates and cellular restriction elevate Emerin expression and diminish differentiation. Conversely, reducing Emerin expression leads to attenuated cell differentiation, where stiffness and constraining factors exert no notable influence. Furthermore, a softening of cells and an enhanced migration rate are also markedly observed. These observations indicate that variations in nuclear skeletal proteins, prompted by diverse matrix microenvironments, play a pivotal role in the pathogenesis of hypertrophic scars (HSs). This research offers novel insights and a reference point for understanding scar fibrosis formation mechanisms and preventing fibrosis.

Talent cultivation for primary training of aviation equipment majors has many modules, many categories, long class hours and cross-fields, and there are realistic difficulties in improving the teaching effect. After a number of training practices and explorations, it is found that collaborative training based on inter-college innovation has obvious advantages. In view of the real problems of aviation equipment professional primary training personnel training, based on the perspective of the advanced theory widely recognized in the education sector -actor network theory (ANT), we have explored the intercollegiate synergistic path with military colleges as the main body, which is of certain practical significance for further improving the comprehensive quality and efficiency of aviation security primary training personnel training.

The curriculum is the basic basis and carrier of educational and teaching activities, and it is the core of the digital transformation of education. With the continuous deep integration of digital technology in the curriculum and teaching, how to effectively deal with the impact and influence of the continuous innovation and breakthrough of digital technology on the curriculum and teaching, and better promote students’ inquiry and personalized learning has become an urgent problem in front of us. This paper focuses on the digital transformation of the background of the curriculum teaching issues, aviation maintenance management course as an example to carry out analysis and research, which can promote the deep integration of digital technology and curriculum teaching to provide reference and reference..

【Background and objective】 Mulched drip irrigation is often used in dry regions for water-saving, but the mulching film could hinder rainfall infiltration and enhance surface runoff as a result. This could reduce the use of natural rainfall by plants, especially in regions where rainfall is abundant in summer and autumn while scarce in other seasons. The objective of this paper is to evaluate the balance of mulched drip irrigation in saving water in dry seasons and losing water in other seasons due to the increased surface runoff. 【Method】 We took pineapple orchard as an example and conducted the experiment in a field comprising three irrigation treatments: conventional rain-fed cultivation (CK), conventional drip irrigation (DF), and mulched drip irrigation with plastic film (MF). In each treatment, we measured the change in moisture in the 0~100 cm soil profile using FDR sensors. 【Result】 Both conventional and mulched drip irrigation reduced rainfall infiltration in the planting rows. The total rainfall infiltration in the 0~100 cm soil profile on the planting ridge under DF and MF was 48.4% and 60.8% respectively lower than that under conventional rain-fed cultivation, despite that MF did not affect the water use efficiency and fruit yield. Compared with CK, DF and MF increased agronomic productivity of the water by 37.5% and 13.8% respectively, and field biomass by 13.8% and 52.2% respectively. MF also increased rainfall infiltration in the 40~100 cm soil in the burrow between the planted ridges. The rainfall infiltration ratio of moderate rainfall, heavy rainfall and rainstorm was 3.5%, 15.8% and 30.3% for DF, 2.5%, 16.7% and 31.5% for DF, and 15.7%, 39.7% and 43.0% for MF. The wetting depth (accounted for when soil moisture increase was >4%) associated with moderate rainfall, heavy rainfall and rainstorm was 30 cm, 100 cm and 30 cm for CF, 20 cm, 30 cm and 20 cm for DF, and 10 cm, 50 cm and 20 cm for MF. It was found that the mulched drip irrigation stabilized soil moisture in the planting rows; in rainy season, the depth of soil moisture content affected by CK, DF and MF was 0~30 cm, 0~20 cm and 0~10 cm respectively. 【Conclusion】 In regions rich in rainfalls in summer and autumn while dry in other seasons, mulched drip irrigation reduced rainfall infiltration and promoted deep infiltration of rainfall, but it does not affect water agronomic productivity and biomass of the pineapple. It is hence beneficial to saving water and increasing pineapple yield.

Hepatic ischemia/reperfusion injury (IRI) is an important factor affecting liver regeneration and functional recovery postoperatively. Many studies have suggested that mesenchymal stem cells (MSCs) contribute to hepatic tissue repair and functional recovery through paracrine mechanisms mediated by exosomes. Minipigs exhibit much more similar characteristics of the liver to those of humans than rodents. This study aimed to explore whether exosomes from adipose-derived MSCs (ADSCs-exo) could actively promote liver regeneration after hepatectomy combined with HIRI in minipigs and the role they play in the cell proliferation process. This study also compared the effects and differences in the role of ADSCs and ADSCs-exo in the inflammatory response and liver regeneration. The results showed that ADSCs-exo suppressed histopathological changes and reduced inflammatory infiltration in the liver; significantly decreased levels of ALT, TBIL, HA, and the pro-inflammatory cytokines TNF-α, IL-6, and CRP; increased levels of the anti-inflammatory cytokine IL-10 and the pro-regeneration factors Ki67, PCNA, CyclinD1, HGF, STAT3, VEGF, ANG1, ANG2; and decreased levels of the anti-regeneration factors SOCS3 and TGF-β. These indicators above showed similar changes with the ADSCs intervention group. Indicating that ADSCs-exo can exert the same role as ADSCs in regulating inflammatory responses and promoting liver regeneration. Our findings provide experimental evidence for the possibility that ADSCs-exo could be considered a safe and effective cell-free therapy to promote regeneration of injured livers. [ABSTRACT FROM AUTHOR]

This study aims to understand the characteristics and distribution patterns of soil phosphorus (P) forms in the tropical high‐P orchards under cover cropping and to explore the biotic and abiotic factors driving the changes in P forms. The study collected three kinds of soil (clean tillage [CK, control], Stylosanthes guianensis cover [SC, legume], and Cynodon dactylon (L.) Pers. cover [CC, grass]) from a mango orchard and determined P forms in the water‐stable aggregates and bulk soil, analyzed the environmental factors and the structure of the bacterial‐fungal community. Compared to CK, SC and CC have a significant positive influence on the forms and distribution of soil P, increase the content of organic P (Org‐P) and certain inorganic P forms (Al‐P and Fe‐P), and enhance the content of P within macroaggregates (>0.25 mm), thereby maintaining total P (TP) and Olsen‐P in the top 30 cm of soil, particularly for the SC treatment. SC and CC also improved acid phosphatase (ACP), and water‐stable aggregates while decreasing bulk density (BD) and exchangeable aluminium (Ale) in the topsoil (0–15 cm). Redundant and Pearson analysis revealed these factors significantly affected soil P availability. Moreover, SC and CC increased the relative abundance of Nitrospira, Candidatus‐Udaeobacter, Pseudolabrys, and ADurb.Bin063–1 in the topsoil (0–15 cm), and decreased the relative abundance of Occallatibacter. Redundant and Pearson analysis indicated that these bacterial communities are likely associated with the availability of P. Overall, cover cropping promoted the transformation and distribution of P forms by altering the physical, chemical, and biological environment of the soil, which was beneficial for the sustainable P management in tropical high‐P soils. This research offers practical insights into the use of cover crops as a tool for enhancing soil health and sustainable P management in tropical high‐P orchards. [ABSTRACT FROM AUTHOR]

AbstractMuscle foods, valued for their significant nutrient content such as high-quality protein, vitamins, and minerals, are vulnerable to adulteration and fraud, stemming from dishonest vendor practices and insufficient market oversight. Traditional analytical methods, often limited to laboratory-scale., may not effectively detect adulteration and fraud in complex applications. Raman spectroscopy (RS), encompassing techniques like Surface-enhanced RS (SERS), Dispersive RS (DRS), Fourier transform RS (FTRS), Resonance Raman spectroscopy (RRS), and Spatially offset RS (SORS) combined with chemometrics, presents a potent approach for both qualitative and quantitative analysis of muscle food adulteration. This technology is characterized by its efficiency, rapidity, and noninvasive nature. This paper systematically summarizes and comparatively analyzes RS technology principles, emphasizing its practicality and efficacy in detecting muscle food adulteration and fraud when combined with chemometrics. The paper also discusses the existing challenges and future prospects in this field, providing essential insights for reviews and scientific research in related fields. [ABSTRACT FROM AUTHOR]

Introducing superconductivity into two-dimensional (2D) films with nontrivial topology has been intensively pursued as one of the feasible scenarios to realize 1D topological superconductor. Prevailing endeavors mostly exploit the external gating or proximity effect of a traditional superconductor, by which the critical temperatures ( T c ) are limited to several Kelvin range. Here, we report on the discovery of interface-enhanced superconductivity in monolayer 1T′-MoTe2 film. A thermally driven phase transition from Mo6Te6 nanowires to 1T′-MoTe2 films, grown on SrTiO3(001) surface by the molecular beam epitaxial methods, is demonstrated. A combined study of scanning tunneling microscopy/spectroscopy, electrical transport and magnetization measurements indicates the T c of MoTe2 film is around 30 K, two orders of magnitude larger than its 3D counterpart crystal. This study shows that interfacial engineering is an efficient way to tune monolayer 1T′-MoTe2 film into superconducting states, and thus may pave the way toward higher- T c 1D intrinsic topological superconductivity. [ABSTRACT FROM AUTHOR]

A representative class of kagome materials, AV3Sb5 (A = K, Rb, Cs), hosts several unconventional phases such as superconductivity, Z 2 non-trivial topological states, and electronic nematic states. These can often coexist with intertwined charge-density wave states. Recently, the discovery of the isostructural titanium-based single-crystals, ATi3Bi5 (A = K, Rb, Cs), which exhibit similar multiple exotic states but without the concomitant charge-density wave, has opened an opportunity to disentangle these complex states in kagome lattices. Here, we combine high-resolution angle-resolved photoemission spectroscopy and first-principles calculations to investigate the low-lying electronic structure of RbTi3Bi5. We demonstrate the coexistence of flat bands and several non-trivial states, including type-II Dirac nodal lines and Z 2 non-trivial topological surface states. Our findings also provide evidence for rotational symmetry breaking in RbTi3Bi5, suggesting a directionality to the electronic structure and the possible emergence of pure electronic nematicity in this family of kagome compounds. Kagome superconductors are a platform for intertwined condensed matter phenomena that may be mediated by band topology. Here, authors use ARPES and DFT to identify type-II Dirac nodal lines, flat bands, topologically non-trivial surface states and signatures of nematicity in the kagome compound RbTi3Bi5. [ABSTRACT FROM AUTHOR]