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4. Lowering systolic blood pressure to less than 120 mm Hg versus less than 140 mm Hg in patients with high cardiovascular risk with and without diabetes or previous stroke: an open-label, blinded-outcome, randomised trial

Author

Ai, Xinyue, An, Chun, An, Yuhong, Bai, Shiru, Bai, Xueke, Bi, Jingao, Bin, Xiaoling, Bu, Miaomiao, Bu, Peili, Bu, Wei, Cai, Lvping, Cai, Nana, Cai, Shuhui, Cai, Ting, Cai, Wenjing, Cao, Bin, Cao, Bingbing, Cao, Huaping, Cao, Libo, Cao, Xiancun, Chai, Hui, Chai, Yonggui, Chai, Zhiyong, Chang, Chunduo, Chang, Jianbao, Chang, Shuyue, Chang, Yunling, Chao, Huanhuan, Che, Hang, Che, Qianqiu, Chen, Danlin, Chen, Dongsheng, Chen, Faxiu, Chen, Guang, Chen, Hairong, Chen, Hao, Chen, Huahua, Chen, Huijun, Chen, Jiafu, Chen, Jian, Chen, Jiasen, Chen, Jing, Chen, Jinzi, Chen, Junrong, Chen, lichun, Chen, Lijuan, Chen, Liyuan, Chen, Qun, Chen, Run, Chen, Shaoxing, Chen, Song, Chen, Tieshuang, Chen, Xianghong, Chen, Xiaowu, Chen, Xudong, Chen, Xue, Chen, Xunchun, Chen, Yao, Chen, Yongli, Chen, Yuanyue, Chen, Yuhong, Chen, Yuyi, Chen, Zhangying, Chen, Zhidong, Chen, Zuyi, Cheng, Caiming, Cheng, Jianbin, Cheng, Xiaoxia, Chu, Junjie, Cui, Ruifeng, Cui, Xiaolin, Cui, Xuechen, Cui, Yang, Cui, Zhonghua, Dai, Wanhong, Dai, Xing, Ding, Chunxia, Ding, Huihong, Ding, Qiuhong, Ding, Yaozong, Ding, Yingjie, Dong, Jiajia, Dong, Lei, Dong, Qi, Dong, Yumei, Du, Bing, Du, Hong, Du, Jie, Du, Laijing, Du, Meiling, Du, Qiong, Du, Tianmin, Du, Xue, Duan, Ru, Duan, Xiaojing, Duan, Xiaoting, Fan, Dandan, Fan, Xiaohong, Fan, Xin, Fang, Fang, Fang, Jing, Fang, Xibo, Fang, Yang, Feng, Erke, Feng, Hejin, Feng, Ling, Feng, Rui, Feng, Zhaohui, Fu, Hongmei, Fu, Qiuai, Gao, Haofei, Gao, Li, Gao, Lina, Gao, Liwei, Gao, Lu, Gao, Min, Gao, Qian, Gao, Yan, Gao, Yuan, Ge, Jinzhuo, Geng, Hongxu, Geng, Hui, Geng, Leijun, Geng, Lianqing, Gou, Hongyan, Gu, Qin, Guan, Lili, Guan, Shuo, Guan, Wenchi, Guan, Zheng, Guang, Bin, Guo, Anran, Guo, Changhong, Guo, Gaofeng, Guo, Lizhi, Guo, Qing, Guo, Qiue, Guo, Ying, Guo, Zhihua, Han, Aihong, Han, Meihong, Han, Suhui, Han, Xinru, Han, Yajun, Hao, Feng, Hao, Jingmin, Hao, Shiguo, He, Chuanhui, He, Dejian, He, Mengyuan, He, Miaomiao, He, Shaojuan, He, Wenkai, He, Xiaoyu, He, Yuxiang, Hong, Jige, Hou, Chuanxing, Hou, Jing, Hu, Danli, Hu, Jian, Hu, Jun, Hu, Lingai, Hu, Mengying, Hu, Zhiyuan, Huang, Anhui, Huang, Chunxia, Huang, Haolin, Huang, Jianlan, Huang, Sha, Huang, Siqi, Huang, Weijun, Huang, Wenxiu, Huang, Xinghe, Huang, Xinsheng, Huang, Xinxin, Hui, Jiliang, Hui, Lijun, Hui, Zhongsheng, Huo, Fangjie, Ji, Runqing, Jia, Guojiong, Jia, Hao, Jia, Jingjing, Jia, Jingmei, Jia, Xiaoling, Jiang, Hua, Jiang, Jingcheng, Jiang, Qian, Jiang, Xianyan, Jiang, Xiaoyuan, Jiang, Yanxiang, Jiao, Yunhong, Jie, Liying, Jin, Binbin, Jin, Lingjiao, Jin, Renshu, Jin, Rong, Jin, Xiang, Jin, Xianping, Jin, Yongfan, Jin, Zepu, Jin, Zhenan, Jing, Chengrong, Jing, Jiajie, Jing, Ruiling, Kang, Liping, Kang, Yu, Kong, Jianqiong, Kou, Shijie, Kou, Xianli, Kulaxihan, Lai, Jijia, Lei, Lubi, Li, Baoxiang, Li, Bin, Li, Bing, Li, Chaohui, Li, Cheng, Li, Chunmei, Li, Chunyan, Li, Daqing, Li, Deen, Li, Di, Li, Feng, Li, Guanyi, Li, Haiyang, Li, Hongwei, Li, Jia, Li, Jialin, Li, Jianan, Li, Jianguang, Li, Jiaying, Li, Jing, Li, Jinmei, Li, Lala, Li, Li, Li, Lijun, Li, Liping, Li, Lize, Li, Mingju, Li, Minglan, Li, Mingyan, Li, Na, Li, Nan, Li, Nana, Li, Qiang, Li, Qianru, Li, Rui, Li, Ruihong, Li, Shanshan, Li, Shilin, Li, Si, Li, Suwen, Li, Tongshe, Li, Tongying, Li, Wanke, Li, Wei, Li, Wenbo, Li, Wenjuan, Li, Xi, Li, Xiangxia, Li, Xiao, Li, Xiaohui, Li, Xingyan, Li, Xiujuan, Li, Yan, Li, Yanfang, Li, Yang, Li, Yanxia, Li, Yaona, Li, Yichong, Li, Ying, Li, Yuqing, Li, Zheng, Li, Zhengye, Liang, Chuanliang, Liang, Jihua, Liang, Jin, Liang, Ke, Liang, Linju, Liang, Tingchen, Liang, Xia, Liang, Xianfeng, Liang, Yanli, Liang, Zhenye, Lie, Zhenbang, Lin, Qingfei, Lin, Ruifang, Lin, Xiao, Lin, Zhiqiang, Liu, Aijun, Liu, Chao, Liu, Chunxia, Liu, Cong, Liu, Fang, Liu, Guaiyan, Liu, Hongjun, Liu, Jiamin, Liu, Jiangling, Liu, Jianqi, Liu, Jieyun, Liu, Jihong, Liu, Jing, Liu, Jinsha, Liu, Juan, Liu, Junfang, Liu, Liming, Liu, Lin, Liu, Ling, Liu, Lu, Liu, Qiang, Liu, Qiaoling, Liu, Qiaoxia, Liu, Qiuxia, Liu, Shaobo, Liu, Xiaobao, Liu, Xiaocheng, Liu, Xiaoyuan, Liu, Xinbo, Liu, Xu, Liu, Yang, Liu, Yanhu, Liu, Yanming, Liu, Yaqin, Liu, Yong, Liu, Zhihong, Long, Jing, Lu, Futang, Lu, Huamei, Lu, Jiapeng, Lu, Junhong, Lu, Weibin, Lu, Yanrong, Lu, Yuchun, Luan, Tianwei, Luo, Qingwei, Luo, Qun, Luo, Tian, Luo, Xia, Luo, Yongmei, Lv, Jing, Lv, Jinhai, Lv, Lei, Lv, Lili, Lv, Meng, Ma, Aiqing, Ma, Huaimin, Ma, Huihuang, Ma, Jie, Ma, Jinbao, Ma, Li, Ma, Lingzhen, Ma, Nan, Ma, Qiaojuan, Ma, Shumei, Ma, Tengfei, Ma, Xiange, Ma, Xiaowen, Ma, Yuehua, Mai, Lanxian, Mei, Xiao, Meng, Gen, Miao, Ruichao, Miao, Xue, Miao, Xuyan, Min, Tingting, Mo, Shubing, Morigentu, Nan, Tingyan, Ni, Jinyang, Ni, Shuguo, Nie, Yu, Ning, Benxing, Ning, Xiaowei, Niu, Manman, Niu, Qingying, Niu, Wentang, Niu, Xiaoxia, Ou, Fang, Pan, Biyun, Pan, Chengjie, Pan, Congming, Pan, Jieli, Pan, Xiaowen, Pan, Ziying, Pei, Guangzhong, Pei, Lingyu, Pei, Min, Pei, Yanzhen, Peng, Yinyu, Peng, Yuming, Pu, Zhaokun, Qi, Fengjun, Qi, Liwei, Qi, Meiqiong, Qi, Yan, Qian, Jun, Qin, Lei, Qin, Zhonghua, Qing, Lan, Qiu, Lixia, Qiu, Weiyu, Qiu, Xiaoling, Qu, Yueli, Quan, Minghua, Ren, Dingping, Ren, Hong, Ren, Lingzhi, Ren, Tingting, Ren, Wei, Ren, Yihui, Rong, Yufang, Ruan, Jiahui, Shang, Peiqin, Shao, Minyan, Shao, Xuefeng, Shao, Yuling, Shen, Junrong, Shen, Rui, Sheng, Lin, Shi, Jiangjie, Shi, Xun, Shi, Yanhong, Shi, Yeju, Shi, Yujiao, Shu, Bo, Song, Bingchun, Song, Dan, Song, Jinhui, Song, Jinwang, Song, Jinxian, Song, Wei, Song, Xiaoping, Song, Yawen, Su, He, Su, Qinfeng, Su, Shuhong, Su, Xiaozhou, Sun, Chengxiang, Sun, Fangfang, Sun, Gongping, Sun, Jiangnan, Sun, Mengmeng, Sun, Rongrong, Sun, Shuting, Sun, Songtao, Sun, Ying, Sun, Yongmiao, Sun, Yunhong, Sun, Zhiqiang, Suo, Mengying, Tan, Binghu, Tang, Chunyan, Tang, Zhongli, Tao, Yu, Tian, Changming, Tian, Hongmei, Tian, Jian, Tian, Xiaomin, Wan, Huaibin, Wan, Qin, Wan, Rongjun, Wang, Bobin, Wang, Chao, Wang, Chaoqun, Wang, Chengliang, Wang, Di, Wang, Enfang, Wang, Feng, Wang, Gang, Wang, Guangqiang, Wang, Guixiang, Wang, Haifeng, Wang, Haijun, Wang, Haiyang, Wang, Jianfang, Wang, Jianfeng, Wang, Jing, Wang, Junping, Wang, Junying, Wang, Kang, Wang, Lei, Wang, Lin, Wang, Lize, Wang, Meng, Wang, Pan, Wang, Qi, Wang, Qiong, Wang, Qiuli, Wang, Qiuxue, Wang, Ran, Wang, Shaojin, Wang, Shuai, Wang, Tao, Wang, Tiantian, Wang, Tinghui, Wang, Tongyan, Wang, Wanhong, Wang, Wenjuan, Wang, Wenyan, Wang, Wenying, Wang, Wenzhuan, Wang, Xiaofei, Wang, Xiaoyan, Wang, Xitong, Wang, Xu, Wang, Yan, Wang, Yanfang, Wang, Yang, Wang, Yanping, Wang, Yanying, Wang, Yaoxin, Wang, Yingli, Wang, Yiting, Wang, Yue, Wang, Yumei, Wang, Yuzhuo, Wang, Zhenhua, Wang, Zhifang, Wang, Zhimin, Wei, Chunli, Wei, Lixia, Wei, Pei, Wei, Shuying, Wei, Xiqing, Wen, Hong, Wen, Yun, Wu, Chaoqun, Wu, Hairong, Wu, Lihua, Wu, Lingxiang, Wu, Qi, Wu, Shaorong, Wu, Wenting, Wu, Xueyi, Wu, Yongshuan, Wu, Zhihao, Wu, Zhuying, Wu, Zongyin, Wuhanbilige, Xia, Jun, Xia, Yang, Xiang, Jing, Xiao, Heliu, Xiao, Yaying, Xie, Meiling, Xie, Yinyan, Xin, Huiling, Xing, Jing, Xiu, Guoquan, Xu, Baohua, Xu, Chuangze, Xu, En, Xu, Jian, Xu, Shuli, Xu, Wei, Xu, Wen, Xue, Na, Xue, Tingting, Xue, Wei, Yan, Haiyan, Yan, Xiaofang, Yan, Yanqing, Yang, Bo, Yang, Hui, Yang, Huiyu, Yang, Jinhua, Yang, Kun, Yang, Man, Yang, Mengya, Yang, Ning, Yang, Ping, Yang, Xiajiao, Yang, Xiaomo, Yang, Xin, Yang, Xiujuan, Yang, Xuemei, Yang, Xuming, Yang, Yan, Yang, Yanhua, Yang, Yi, Yang, Yuanyuan, Yang, Zhimei, Yang, Zhiming, Yao, Hui, Yao, Lu, Ye, Jinling, Ye, Wenhua, Yi, Mingjiao, Yi, Shaowei, Yi, Wenyi, Yi, Zhimin, Yin, Guangxia, Yin, Guoyuan, Yu, Guibin, Yu, Hairong, Yu, Huaitao, Yu, Lijie, Yu, Lijun, Yu, Nana, Yu, Qin, Yu, Xinli, Yu, Yi, Yuan, Biao, Zeng, Chunmei, Zhai, Na, Zhai, Xiaojuan, Zhan, Hongju, Zhang, Aizhen, Zhang, Baohua, Zhang, Bin, Zhang, Caizhu, Zhang, Chaoying, Zhang, Chengbo, Zhang, Chunlai, Zhang, Churuo, Zhang, Fan, Zhang, Feiqin, Zhang, Ge, Zhang, Haibo, Zhang, Hailin, Zhang, Hanxue, Zhang, Huaixing, Zhang, Hui, Zhang, Huijuan, Zhang, Jinguo, Zhang, Jingyu, Zhang, Jinyun, Zhang, Jisheng, Zhang, Jun, Zhang, Lei, Zhang, Li, Zhang, Liang, Zhang, Lifeng, Zhang, Lina, Zhang, Liping, Zhang, Min, Zhang, Ping, Zhang, Qiang, Zhang, Rufang, Zhang, Ruifen, Zhang, Shengde, Zhang, Siqi, Zhang, Sufang, Zhang, Tingting, Zhang, Wanyue, Zhang, Weiliang, Zhang, Xiaohan, Zhang, Xiaohong, Zhang, Xiaojuan, Zhang, Xin, Zhang, Xue, Zhang, Xuewei, Zhang, Yachen, Zhang, Yang, Zhang, Yanyan, Zhang, Yaojie, Zhang, Yingyu, Zhang, Yuan, Zhang, Yun, Zhang, Yunfeng, Zhang, Zaozhang, Zhang, Zhichao, Zhao, Baihui, Zhao, Dan, Zhao, Fuxian, Zhao, Guizeng, Zhao, Haijie, Zhao, Honglei, Zhao, Huizhen, Zhao, Jindong, Zhao, Juan, Zhao, Liming, Zhao, Ling, Zhao, Lingshan, Zhao, Qingxia, Zhao, Qiuping, Zhao, Wanchen, Zhao, Wangxiu, Zhao, Weiyi, Zhao, Xiaodi, Zhao, Xiaojing, Zhao, Xiaoli, Zhao, Xiaoyan, Zhao, Xiling, Zhao, Yannan, Zhao, Yiyuan, Zheng, Shuzhen, Zheng, Xin, Zhi, Lixia, Zhong, Hui, Zhong, Qing, Zhong, Xin, Zhong, Yunzhi, Zhou, Jianfeng, Zhou, Jihu, Zhou, Ke, Zhou, Liangliang, Zhou, Ling, Zhou, Na, Zhou, Shengcheng, Zhou, Suyun, Zhou, Tao, Zhou, Wanren, Zhou, Weifeng, Zhou, Weijuan, Zhou, Xiaohong, Zhou, Yunke, Zhou, Yuquan, Zhou, Zhaohai, Zhou, Zhiming, Zhu, Bingpo, Zhu, Jifa, Zhu, Jing, Zhu, Mengnan, Zhu, Youcun, Zong, Dafei, Zuo, Hongbo, and Zuo, Zhaokai

Published
2024
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5. Identification method for inter-turn faults in transformers based on digital twin concept

Author

Ma Aiqing, Gao Dawei, Qin Tonghui, and Wang Wei

Subjects
oil immersed transformer, digital twin, bald eagle search algorithm, inter-turn fault, multiple physical characteristic parameters, fault identification, General Works
Abstract

A transformer inter-turn fault identification method is proposed based on the digital twin concept to tackle the challenges of high operational complexity and low accuracy associated with traditional transformer fault identification methods. Initially, the Bald Eagle Search algorithm is employed to optimize the critical parameters of the Extreme Learning Machine (ELM), determining the optimal input layer weight and hidden layer threshold of the Extreme Learning Machine. Subsequently, leveraging the digital twin concept, a digital replica of the physical transformer is established, enabling multi-physical field coupling simulation encompassing electrical, thermal, and acoustic domains to elucidate the variation patterns of various physical parameters across different operational scenarios and fault scenarios. Furthermore, key physical characteristic parameters such as sound pressure and winding hot spot temperature are carefully selected to drive a fault identification model tailored to inter-turn faults within the framework of the digital twin concept. Through a detailed investigation using 630 kV A/10 kV transformers as a case study, the results exhibit an impressive fault identification accuracy of 95.24% for the proposed method. Comparative analysis reveals notable enhancements in fault identification accuracy of 12.22%, 7.85%, and 3.73% for ELM, Support Vector Machine and Tuna Swarm Optimization—ELM models, respectively. These findings underscore the effectiveness and practicality of the transformer inter-turn fault identification method based on the digital twin concept, offering valuable insights for the real-time monitoring and diagnosis of inter-turn faults in transformers.

Published
2024
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11. Application and Challenge of Metalloporphyrin Sensitizers in Noninvasive Dynamic Tumor Therapy.

Author

Ouyang, Jiacheng, Li, Dan, Zhu, Lizhen, Cai, Xiaoyuan, Liu, Lanlan, Pan, Hong, and Ma, Aiqing

Subjects
PHOTODYNAMIC therapy, PHOTOSENSITIZERS, METALLOPORPHYRINS, CYTOTOXINS, PORPHYRINS
Abstract

Dynamic tumor therapies (mainly including photodynamic therapy (PDT) and sonodynamic therapy (SDT)) offer new approaches to cancer treatment. They are often characterized by their noninvasive nature, high selectivity, and low toxicity. Sensitizers are crucial for dynamic therapy. Developing efficient sensitizers with good biocompatibility and controllability is an important aim in dynamic therapy. Porphyrins and metalloporphyrins attract great attention due to their excellent photophysical properties and low cytotoxicity under non-light. Compared to porphyrins, metalloporphyrins show greater potential for dynamic therapy due to their enhanced photochemical and photophysical properties after metal ions coordinate with porphyrin rings. This paper reviews some metalloporphyrin-based sensitizers used in photo/sonodynamic therapy and combined therapy. In addition, the probable challenges and bottlenecks in clinical translation are also discussed. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Lowering systolic blood pressure to less than 120 mm Hg versus less than 140 mm Hg in patients with high cardiovascular risk with and without diabetes or previous stroke: an open-label, blinded-outcome, randomised trial

Author

Liu, Jiamin, Li, Yan, Ge, Jinzhuo, Yan, Xiaofang, Zhang, Haibo, Zheng, Xin, Lu, Jiapeng, Li, Xi, Gao, Yan, Lei, Lubi, Liu, Jing, Li, Jing, Ai, Xinyue, An, Chun, An, Yuhong, Bai, Shiru, Bai, Xueke, Bi, Jingao, Bin, Xiaoling, Bu, Miaomiao, Bu, Peili, Bu, Wei, Cai, Lvping, Cai, Nana, Cai, Shuhui, Cai, Ting, Cai, Wenjing, Cao, Bin, Cao, Bingbing, Cao, Huaping, Cao, Libo, Cao, Xiancun, Chai, Hui, Chai, Yonggui, Chai, Zhiyong, Chang, Chunduo, Chang, Jianbao, Chang, Shuyue, Chang, Yunling, Chao, Huanhuan, Che, Hang, Che, Qianqiu, Chen, Danlin, Chen, Dongsheng, Chen, Faxiu, Chen, Guang, Chen, Hairong, Chen, Hao, Chen, Huahua, Chen, Huijun, Chen, Jiafu, Chen, Jian, Chen, Jian, Chen, Jiasen, Chen, Jing, Chen, Jinzi, Chen, Junrong, Chen, lichun, Chen, Lijuan, Chen, Liyuan, Chen, Qun, Chen, Run, Chen, Shaoxing, Chen, Song, Chen, Tieshuang, Chen, Xianghong, Chen, Xiaowu, Chen, Xudong, Chen, Xue, Chen, Xunchun, Chen, Yao, Chen, Yongli, Chen, Yuanyue, Chen, Yuhong, Chen, Yuyi, Chen, Zhangying, Chen, Zhidong, Chen, Zuyi, Cheng, Caiming, Cheng, Jianbin, Cheng, Xiaoxia, Chu, Junjie, Cui, Ruifeng, Cui, Xiaolin, Cui, Xuechen, Cui, Yang, Cui, Zhonghua, Dai, Wanhong, Dai, Xing, Ding, Chunxia, Ding, Huihong, Ding, Qiuhong, Ding, Yaozong, Ding, Yingjie, Dong, Jiajia, Dong, Lei, Dong, Qi, Dong, Yumei, Du, Bing, Du, Hong, Du, Jie, Du, Laijing, Du, Meiling, Du, Qiong, Du, Tianmin, Du, Xue, Duan, Ru, Duan, Xiaojing, Duan, Xiaoting, Fan, Dandan, Fan, Xiaohong, Fan, Xin, Fang, Fang, Fang, Jing, Fang, Xibo, Fang, Yang, Feng, Erke, Feng, Hejin, Feng, Ling, Feng, Rui, Feng, Zhaohui, Fu, Hongmei, Fu, Qiuai, Gao, Haofei, Gao, Li, Gao, Lina, Gao, Liwei, Gao, Lu, Gao, Min, Gao, Min, Gao, Qian, Gao, Yan, Gao, Yuan, Ge, Jinzhuo, Geng, Hongxu, Geng, Hui, Geng, Leijun, Geng, Lianqing, Gou, Hongyan, Gu, Qin, Guan, Lili, Guan, Shuo, Guan, Wenchi, Guan, Zheng, Guang, Bin, Guo, Anran, Guo, Changhong, Guo, Gaofeng, Guo, Lizhi, Guo, Qing, Guo, Qiue, Guo, Ying, Guo, Zhihua, Han, Aihong, Han, Meihong, Han, Suhui, Han, Xinru, Han, Yajun, Hao, Feng, Hao, Jingmin, Hao, Shiguo, He, Chuanhui, He, Dejian, He, Mengyuan, He, Miaomiao, He, Shaojuan, He, Wenkai, He, Xiaoyu, He, Yuxiang, Hong, Jige, Hou, Chuanxing, Hou, Jing, Hu, Danli, Hu, Jian, Hu, Jun, Hu, Lingai, Hu, Mengying, Hu, Zhiyuan, Huang, Anhui, Huang, Chunxia, Huang, Haolin, Huang, Jianlan, Huang, Sha, Huang, Siqi, Huang, Weijun, Huang, Wenxiu, Huang, Xinghe, Huang, Xinsheng, Huang, Xinxin, Hui, Jiliang, Hui, Lijun, Hui, Zhongsheng, Huo, Fangjie, Ji, Runqing, Ji, Runqing, Jia, Guojiong, Jia, Hao, Jia, Jingjing, Jia, Jingmei, Jia, Xiaoling, Jiang, Hua, Jiang, Jingcheng, Jiang, Qian, Jiang, Xianyan, Jiang, Xiaoyuan, Jiang, Yanxiang, Jiao, Yunhong, Jie, Liying, Jin, Binbin, Jin, Lingjiao, Jin, Renshu, Jin, Rong, Jin, Xiang, Jin, Xianping, Jin, Yongfan, Jin, Zepu, Jin, Zhenan, Jing, Chengrong, Jing, Jiajie, Jing, Ruiling, Kang, Liping, Kang, Yu, Kong, Jianqiong, Kou, Shijie, Kou, Xianli, Kulaxihan, Lai, Jijia, Lei, Lubi, Li, Baoxiang, Li, Bin, Li, Bing, Li, Chaohui, Li, Cheng, Li, Chunmei, Li, Chunyan, Li, Daqing, Li, Deen, Li, Di, Li, Feng, Li, Guanyi, Li, Haiyang, Li, Hongwei, Li, Jia, Li, Jialin, Li, Jianan, Li, Jianguang, Li, Jiaying, Li, Jing, Li, Jing, Li, Jinmei, Li, Lala, Li, Li, Li, Lijun, Li, Liping, Li, Lize, Li, Mingju, Li, Minglan, Li, Mingyan, Li, Na, Li, Na, Li, Nan, Li, Nana, Li, Qiang, Li, Qianru, Li, Rui, Li, Ruihong, Li, Shanshan, Li, Shilin, Li, Si, Li, Suwen, Li, Tongshe, Li, Tongying, Li, Wanke, Li, Wei, Li, Wenbo, Li, Wenjuan, Li, Xi, Li, Xiangxia, Li, Xiao, Li, Xiaohui, Li, Xingyan, Li, Xiujuan, Li, Yan, Li, Yanfang, Li, Yang, Li, Yanxia, Li, Yaona, Li, Yichong, Li, Ying, Li, Yuqing, Li, Zheng, Li, Zhengye, Liang, Chuanliang, Liang, Jihua, Liang, Jin, Liang, Ke, Liang, Linju, Liang, Tingchen, Liang, Xia, Liang, Xianfeng, Liang, Yanli, Liang, Zhenye, Lie, Zhenbang, Lin, Qingfei, Lin, Ruifang, Lin, Xiao, Lin, Zhiqiang, Liu, Aijun, Liu, Chao, Liu, Chunxia, Liu, Cong, Liu, Fang, Liu, Fang, Liu, Guaiyan, Liu, Hongjun, Liu, Jiamin, Liu, Jiangling, Liu, Jianqi, Liu, Jieyun, Liu, Jihong, Liu, Jing, Liu, Jinsha, Liu, Juan, Liu, Junfang, Liu, Liming, Liu, Lin, Liu, Lin, Liu, Lin, Liu, Ling, Liu, Lu, Liu, Qiang, Liu, Qiaoling, Liu, Qiaoxia, Liu, Qiuxia, Liu, Shaobo, Liu, Xiaobao, Liu, Xiaocheng, Liu, Xiaoyuan, Liu, Xinbo, Liu, Xu, Liu, Yang, Liu, Yanhu, Liu, Yanming, Liu, Yaqin, Liu, Yong, Liu, Zhihong, Long, Jing, Lu, Futang, Lu, Huamei, Lu, Jiapeng, Lu, Junhong, Lu, Weibin, Lu, Yanrong, Lu, Yuchun, Luan, Tianwei, Luo, Qingwei, Luo, Qun, Luo, Tian, Luo, Xia, Luo, Yongmei, Lv, Jing, Lv, Jinhai, Lv, Lei, Lv, Lili, Lv, Meng, Ma, Aiqing, Ma, Huaimin, Ma, Huihuang, Ma, Jie, Ma, Jinbao, Ma, Li, Ma, Lingzhen, Ma, Nan, Ma, Qiaojuan, Ma, Shumei, Ma, Tengfei, Ma, Xiange, Ma, Xiaowen, Ma, Yuehua, Mai, Lanxian, Mei, Xiao, Meng, Gen, Miao, Ruichao, Miao, Xue, Miao, Xuyan, Min, Tingting, Mo, Shubing, Morigentu, Nan, Tingyan, Ni, Jinyang, Ni, Shuguo, Nie, Yu, Ning, Benxing, Ning, Xiaowei, Niu, Manman, Niu, Qingying, Niu, Wentang, Niu, Xiaoxia, Ou, Fang, Pan, Biyun, Pan, Chengjie, Pan, Congming, Pan, Jieli, Pan, Xiaowen, Pan, Ziying, Pei, Guangzhong, Pei, Lingyu, Pei, Min, Pei, Yanzhen, Peng, Yinyu, Peng, Yuming, Pu, Zhaokun, Qi, Fengjun, Qi, Liwei, Qi, Meiqiong, Qi, Yan, Qian, Jun, Qin, Lei, Qin, Zhonghua, Qing, Lan, Qiu, Lixia, Qiu, Weiyu, Qiu, Xiaoling, Qu, Yueli, Quan, Minghua, Ren, Dingping, Ren, Hong, Ren, Lingzhi, Ren, Tingting, Ren, Wei, Ren, Yihui, Rong, Yufang, Ruan, Jiahui, Shang, Peiqin, Shao, Minyan, Shao, Xuefeng, Shao, Yuling, Shen, Junrong, Shen, Rui, Sheng, Lin, Shi, Jiangjie, Shi, Xun, Shi, Yanhong, Shi, Yeju, Shi, Yujiao, Shu, Bo, Song, Bingchun, Song, Dan, Song, Jinhui, Song, Jinwang, Song, Jinxian, Song, Wei, Song, Xiaoping, Song, Yawen, Su, He, Su, Qinfeng, Su, Shuhong, Su, Xiaozhou, Sun, Chengxiang, Sun, Fangfang, Sun, Gongping, Sun, Jiangnan, Sun, Mengmeng, Sun, Rongrong, Sun, Shuting, Sun, Songtao, Sun, Ying, Sun, Yongmiao, Sun, Yunhong, Sun, Zhiqiang, Suo, Mengying, Tan, Binghu, Tang, Chunyan, Tang, Zhongli, Tao, Yu, Tian, Changming, Tian, Hongmei, Tian, Jian, Tian, Xiaomin, Wan, Huaibin, Wan, Qin, Wan, Rongjun, Wang, Bobin, Wang, Chao, Wang, Chaoqun, Wang, Chengliang, Wang, Di, Wang, Enfang, Wang, Feng, Wang, Gang, Wang, Guangqiang, Wang, Guixiang, Wang, Haifeng, Wang, Haijun, Wang, Haiyang, Wang, Jianfang, Wang, Jianfeng, Wang, Jing, Wang, Junping, Wang, Junying, Wang, Kang, Wang, Lei, Wang, Lei, Wang, Lin, Wang, Lize, Wang, Meng, Wang, Pan, Wang, Qi, Wang, Qiong, Wang, Qiuli, Wang, Qiuxue, Wang, Ran, Wang, Shaojin, Wang, Shuai, Wang, Tao, Wang, Tiantian, Wang, Tinghui, Wang, Tongyan, Wang, Wanhong, Wang, Wenjuan, Wang, Wenyan, Wang, Wenying, Wang, Wenzhuan, Wang, Xiaofei, Wang, Xiaoyan, Wang, Xitong, Wang, Xu, Wang, Yan, Wang, Yan, Wang, Yan, Wang, Yanfang, Wang, Yang, Wang, Yang, Wang, Yanping, Wang, Yanying, Wang, Yaoxin, Wang, Yingli, Wang, Yiting, Wang, Yue, Wang, Yumei, Wang, Yuzhuo, Wang, Zhenhua, Wang, Zhifang, Wang, Zhimin, Wei, Chunli, Wei, Lixia, Wei, Pei, Wei, Shuying, Wei, Xiqing, Wen, Hong, Wen, Yun, Wu, Chaoqun, Wu, Hairong, Wu, Lihua, Wu, Lingxiang, Wu, Qi, Wu, Shaorong, Wu, Wenting, Wu, Xueyi, Wu, Yongshuan, Wu, Zhihao, Wu, Zhuying, Wu, Zongyin, Wuhanbilige, Xia, Jun, Xia, Yang, Xiang, Jing, Xiao, Heliu, Xiao, Yaying, Xie, Meiling, Xie, Yinyan, Xin, Huiling, Xing, Jing, Xiu, Guoquan, Xu, Baohua, Xu, Chuangze, Xu, En, Xu, Jian, Xu, Shuli, Xu, Wei, Xu, Wen, Xue, Na, Xue, Tingting, Xue, Wei, Yan, Haiyan, Yan, Xiaofang, Yan, Yanqing, Yang, Bo, Yang, Hui, Yang, Huiyu, Yang, Jinhua, Yang, Kun, Yang, Man, Yang, Mengya, Yang, Ning, Yang, Ping, Yang, Xiajiao, Yang, Xiaomo, Yang, Xin, Yang, Xiujuan, Yang, Xuemei, Yang, Xuming, Yang, Yan, Yang, Yanhua, Yang, Yi, Yang, Yuanyuan, Yang, Zhimei, Yang, Zhiming, Yao, Hui, Yao, Lu, Ye, Jinling, Ye, Wenhua, Yi, Mingjiao, Yi, Shaowei, Yi, Wenyi, Yi, Zhimin, Yin, Guangxia, Yin, Guoyuan, Yu, Guibin, Yu, Hairong, Yu, Huaitao, Yu, Lijie, Yu, Lijun, Yu, Nana, Yu, Qin, Yu, Xinli, Yu, Yi, Yuan, Biao, Zeng, Chunmei, Zhai, Na, Zhai, Xiaojuan, Zhan, Hongju, Zhang, Aizhen, Zhang, Baohua, Zhang, Bin, Zhang, Caizhu, Zhang, Chaoying, Zhang, Chengbo, Zhang, Chunlai, Zhang, Churuo, Zhang, Fan, Zhang, Feiqin, Zhang, Ge, Zhang, Haibo, Zhang, Hailin, Zhang, Hanxue, Zhang, Huaixing, Zhang, Hui, Zhang, Huijuan, Zhang, Jinguo, Zhang, Jingyu, Zhang, Jinyun, Zhang, Jisheng, Zhang, Jun, Zhang, Lei, Zhang, Li, Zhang, Li, Zhang, Liang, Zhang, Lifeng, Zhang, Lina, Zhang, Liping, Zhang, Liping, Zhang, Min, Zhang, Ping, Zhang, Qiang, Zhang, Rufang, Zhang, Ruifen, Zhang, Shengde, Zhang, Siqi, Zhang, Sufang, Zhang, Tingting, Zhang, Wanyue, Zhang, Weiliang, Zhang, Xiaohan, Zhang, Xiaohong, Zhang, Xiaojuan, Zhang, Xin, Zhang, Xin, Zhang, Xue, Zhang, Xuewei, Zhang, Yachen, Zhang, Yang, Zhang, Yanyan, Zhang, Yaojie, Zhang, Yingyu, Zhang, Yuan, Zhang, Yun, Zhang, Yunfeng, Zhang, Zaozhang, Zhang, Zhichao, Zhao, Baihui, Zhao, Dan, Zhao, Fuxian, Zhao, Guizeng, Zhao, Haijie, Zhao, Honglei, Zhao, Huizhen, Zhao, Jindong, Zhao, Juan, Zhao, Liming, Zhao, Ling, Zhao, Lingshan, Zhao, Qingxia, Zhao, Qiuping, Zhao, Wanchen, Zhao, Wangxiu, Zhao, Weiyi, Zhao, Xiaodi, Zhao, Xiaojing, Zhao, Xiaoli, Zhao, Xiaoyan, Zhao, Xiling, Zhao, Yannan, Zhao, Yiyuan, Zheng, Shuzhen, Zheng, Xin, Zhi, Lixia, Zhong, Hui, Zhong, Qing, Zhong, Xin, Zhong, Yunzhi, Zhou, Jianfeng, Zhou, Jihu, Zhou, Ke, Zhou, Liangliang, Zhou, Ling, Zhou, Na, Zhou, Shengcheng, Zhou, Suyun, Zhou, Tao, Zhou, Wanren, Zhou, Weifeng, Zhou, Weijuan, Zhou, Xiaohong, Zhou, Yunke, Zhou, Yuquan, Zhou, Zhaohai, Zhou, Zhiming, Zhu, Bingpo, Zhu, Jifa, Zhu, Jing, Zhu, Mengnan, Zhu, Youcun, Zong, Dafei, Zuo, Hongbo, and Zuo, Zhaokai

Abstract

Uncertainty exists about whether lowering systolic blood pressure to less than 120 mm Hg is superior to that of less than 140 mm Hg, particularly in patients with diabetes and patients with previous stroke.

Published
2024
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27. Biomimetic Nanosonosensitizers Combined with Noninvasive Ultrasound Actuation to Reverse Drug Resistance and Sonodynamic-Enhanced Chemotherapy against Orthotopic Glioblastoma

Author

Chen, Huaqing, primary, Zhang, Shengping, additional, Fang, Quan, additional, He, Huamei, additional, Ren, Jian, additional, Sun, Da, additional, Lai, Jiazheng, additional, Ma, Aiqing, additional, Chen, Ze, additional, Liu, Lanlan, additional, Liang, Ruijing, additional, and Cai, Lintao, additional

Published
2022
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29. Diosmetin Inhibits Cell Proliferation, Induces Cell Apoptosis and Cell Cycle Arrest in Liver Cancer

Author

Ma, Aiqing and Zhang, Rui

Subjects
liver cancer, cell apoptosis, Cancer Management and Research, cell cycle arrest, diosmetin, HepG2 cell, Original Research
Abstract

Aiqing Ma,1 Rui Zhang2 1Department of Operating Room, Linyi Cancer Hospital, Linyi, Shandong, People’s Republic of China; 2Department of Thoracic Surgery, Linyi Cancer Hospital, Linyi, Shandong, People’s Republic of ChinaCorrespondence: Rui ZhangDepartment of Thoracic Surgery, Linyi Cancer Hospital, Linyi, Shandong 276001, People’s Republic of ChinaEmail Zhangruidoctor123@163.comObjective: Diosmetin (DIOS) has been confirmed to possess anti-cancer effects in some types of tumors. However, it remains unclear whether DIOS exerts anti-cancer effects on liver cancer. Thus, our purpose was to observe the effect of DIOS on cell proliferation, cell apoptosis and cell cycle arrest in human liver cancer cells.MaterialsandMethods: The cell viability of HepG2 and HCC-LM3 cells under different concentrations of DIOS was detected using MTT assay. The cell apoptosis and cell cycle arrest were analyzed by flow cytometry. The expression levels of apoptosis/cell cycle-related proteins including P53, Bcl-2, Bax, cleaved-caspase3, cleaved-caspase8, cleaved-PARP, Bak, cdc2, cyclinB1 and P21 were measured using Western blot. HepG2 cells were transfected by checkpoint kinase 1 (Chk1)-small interfering RNA (siRNA) and checkpoint kinase 2 (Chk2)-siRNA, respectively. After that, cell cycle was detected.Results: DIOS significantly suppressed cell proliferation and induced cell apoptosis of HepG2 cells and HCC-LM3 cells. Moreover, DIOS promoted cell cycle arrest in G2/M phase. Western blot results showed that DIOS significantly suppressed the expression levels of Bcl-2, cdc2, cyclinB1, and promoted the expression levels of Bax, cleaved-caspase3, cleaved-caspase8, cleaved-PARP, Bak, P53, and P21. The G2/M phase arrest was observed in HepG2 cells transfected with Chk2-siRNA, while the G2/M phase arrest was not obvious in HepG2 cells transfected with Chk1-siRNA.Conclusion: Our findings revealed that DIOS could inhibit cell proliferation and promote cell apoptosis and cell cycle arrest in liver cancer. Furthermore, DIOS could induce G2/M cell cycle arrest in HepG2 cell via targeting Chk2.Keywords: diosmetin, cell apoptosis, cell cycle arrest, liver cancer, HepG2 cell

Published
2020

37. A Dual-Biomineralized Yeast Micro-/Nanorobot with Self-Driving Penetration for Gastritis Therapy and Motility Recovery

Author

Zhang, Lishan, Zhang, Baozhen, Liang, Ruijing, Ran, Hui, Zhu, Denghui, Ren, Jian, Liu, Lanlan, Ma, Aiqing, and Cai, Lintao

Abstract

Micro-/nanorobots have attracted great interest in the field of drug delivery and treatment, while preparations for biocompatible robots are extremely challenging. Here, a self-driving yeast micro-/nanorobot (Cur@CaY-robot) is designed via dual biomineralization and acid catalysis of calcium carbonate (CaCO3). Inner nano-CaCO3inside yeast cells (CaY) is biomineralized through cell respiration and provides nanoscaffolds for highly encapsulating curcumin (Cur). Meanwhile, the CaCO3crystals outside yeast cells (outer-CaCO3) through uniaxial growth offer an asymmetric power source for self-propelled motility. The Cur@CaY-robot displays an efficient motion in gastric acid, with the potential for deep penetration to the thick gastric mucus, which significantly improves the accumulation of drug agents in the stomach wall tissue for robust gastritis therapy. More importantly, Ca2+cations released from the Cur@CaY-robot also synergistically repair the gastric motility of gastritis mice. Such yeast micro-/nanorobots exhibit desirable biocompatibility and biodegradability with a good loading capacity for drugs. This work provides an idea for the design of micro-/nanorobots through an environmentally friendly biosynthesis strategy for active drug delivery and precise therapy.

Published
2023
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39. Targeted Cancer Therapy: Sequential Magneto‐Actuated and Optics‐Triggered Biomicrorobots for Targeted Cancer Therapy (Adv. Funct. Mater. 11/2021)

Author

Xing, Jiehua, primary, Yin, Ting, additional, Li, Shuiming, additional, Xu, Tiantian, additional, Ma, Aiqing, additional, Chen, Ze, additional, Luo, Yingmei, additional, Lai, Zhengyu, additional, Lv, Yingnian, additional, Pan, Hong, additional, Liang, Ruijing, additional, Wu, Xinyu, additional, Zheng, Mingbin, additional, and Cai, Lintao, additional

Published
2021
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43. Sequential Magneto‐Actuated and Optics‐Triggered Biomicrorobots for Targeted Cancer Therapy

Author

Xing, Jiehua, primary, Yin, Ting, additional, Li, Shuiming, additional, Xu, Tiantian, additional, Ma, Aiqing, additional, Chen, Ze, additional, Luo, Yingmei, additional, Lai, Zhengyu, additional, Lv, Yingnian, additional, Pan, Hong, additional, Liang, Ruijing, additional, Wu, Xinyu, additional, Zheng, Mingbin, additional, and Cai, Lintao, additional

Published
2020
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