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Child abuse is a significant public health issue that can affect children's physical and mental health. However, few studies have examined rural Chinese left-behind children. The role of social cohesion of rural Chinese communities in the prevention of child abuse remains understudied. The present study aims to investigate certain factors that could reduce child abuse problems, placing a special focus on the protective role of social cohesion, especially for left-behind rural children. Data were collected from a sample of 1,049 school-aged rural children from the largest middle school in China's Henan Province. It was found that social cohesion directly affected physical abuse and emotional abuse; furthermore, social cohesion was more significantly associated with emotional abuse, whereas sexual abuse was a more significant issue for left-behind children than for those living with their parents. However, the moderating effect of the left-behind status on the association between social cohesion and physical abuse was not significant. Our findings suggest that social cohesion is an important factor for preventing emotional and sexual abuse. Thus, it is necessary to enhance social cohesion in rural Chinese communities with left-behind children to reduce their risk of experiencing child abuse. [ABSTRACT FROM AUTHOR]

Background: To characterize the population of critically ill patients and infections treated with linezolid in the intensive care unit (ICU), and to evaluate the clinical efficacy and safety of linezolid therapy., Methods: This multi-center, observational, real-world study was conducted across 52 hospitals between June 9, 2018, and December 28, 2019. Patients who met the following inclusion criteria were included: (1) admitted to the ICU, (2) of any age group, and (3) having a clinical or laboratory diagnosis of a Gram-positive bacterial infection. Clinical efficacy was categorized as success (cured or improved), failed, or non-evaluable. Adverse events and serious adverse events were recorded during treatment., Results: A total of 366 ICU patients who met the inclusion criteria were evaluated. Linezolid was used as second- and first-line treatment in 232 (63.4%) and 134 (36.6%) patients, respectively. The most common isolated strain was Staphylococcus aureus (methicillin-resistant Staphylococcus aureus: n =37/119, 31.1%; methicillin-susceptible Staphylococcus aureus: n =15/119, 12.6%); this was followed by Enterococci (vancomycin-resistant Enterococci: n =8/119, 6.7%; vancomycin-susceptible Enterococci: n =11/119, 9.2%) and Streptococcus pneumoniae (multidrug-resistant: n =4/119, 3.4%; non-multidrug resistant: n =2/119, 1.7%). The main infection sites where pathogens were detected included the lung ( n =216/366, 59.6%), skin and soft tissue ( n =104/366, 28.4%), and blood ( n =50/366, 13.7%). Clinical success was achieved in 301 (82.2%) patients; 34 (9.3%) were cured and 267 (73.0%) improved; treatment failure and non-evaluable outcomes were observed in 29 (7.9%) in 36 (9.8%) patients, respectively. Linezolid-related adverse events were reported in 8 (2.2%) patients. No treatment-related serious adverse events were reported., Conclusions: Based on real-world results, linezolid was found to be effective and safe in the treatment of Gram-positive bacterial infections in critically ill patients., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2022 The Authors. Published by Elsevier B.V. on behalf of Chinese Medical Association.)