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Arm swing is an inherent aspect of human locomotion that enhances lower limb (LL) muscle activation, which may explain its benefits for stroke rehabilitation over fixed-arm approaches. This study analyzed how restricting arm movement affects LL muscle coordination by comparing treadmill walking with arms (WWA) and walking with no arms (WNA) through muscle synergy analysis. Surface electromyography was recorded from eight LL muscles in ten healthy participants. Significant differences were found in muscle activity envelopes at 50% of the gait cycle (GC) for the Gluteus Medius, 0% and 100% GC for the Vastus Lateralis and Semitendinosus, and 25% GC for the Semitendinosus, Gastrocnemius Medialis, and Soleus. The Rectus Femoris and Vastus Lateralis showed higher variability and activation in WNA compared to WWA. Synergy analysis revealed four muscle synergies, with a median global variance of 95%. While spatial components were similar, temporal differences emerged at 0% GC for Synergy 1, 5% and 90% GC for Synergy 2, and 95% GC for Synergy 3 (p < 0.05). Our results suggest that arm swing influences LL muscle activity and coordination during walking. Future studies will aim at understanding the effects of arm swing in stroke rehabilitation, which could help design more effective gait rehabilitation protocols including arm swing. [ABSTRACT FROM AUTHOR]

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Abstract Stiff knee gait (SKG) occurrence after a stroke is associated with various abnormal muscle activities; however, the interactions among these muscles are unclear. This study aimed to elucidate the muscle synergy characteristics during walking in patients with SKG after a stroke. This cross-sectional study included 20 patients with poststroke SKG (SKG group), 16 patients without poststroke SKG (non-SKG group), and 15 healthy adults (control group). Participants walked a 10-m distance at a comfortable speed, and electromyographic data were recorded from six lower-limb muscles. Non-negative matrix factorization was employed to derive time-varying activity (C), muscle weights (W), and the percentage of total variance accounted for (tVAF) for muscle synergies. The SKG group showed a higher tVAF than the control group. The initial stance module (including knee extensors) showed increased activity during the swing phase. The initial swing module (including hip flexors and ankle dorsiflexors) exhibited a higher activity during the single-support phase but a lower activity during the swing phase. The synergy structure in patients with SKG after stroke was simplified, with specific abnormalities in synergy activities. SKG may arise from several synergy alterations involving multiple muscles, indicating that approaches focused on controlling individual muscle activities are unsuitable.

Hand-Eye Coordination (HEC) and Hand Grip Strength (HGS) are among the most important skills in Taekwondo. On a technical level, HEC reflects neuromuscular coordination ability which enables quick responses, and HGS reflects muscle strength which indicates the strength and overall health of the athletes. Combined together, HEC and HGS likely allow Taekwondo athletes to perform better. The aim of this study was to identify if there is a relationship between HEC and HGS in elite Taekwondo athletes. 166 elite Taekwondo athletes (141 males, 25 females) voluntarily participated in this study and were divided into two categories: seniors (age >17 years) and juniors (age =17 years). HEC was assessed by hand-eye coordination manual dexterity test (Lafayette, IN, US) and HGS was measured using a hand dynamometer (Takei, Niigata, Japan). The results revealed that no significant relationship was observed between HEC and HGS (p>0.05) in elite Taekwondo athletes. Despite the several strength and neuromuscular adaptations acquired during Taekwondo practice, HEC and HGS are not significantly correlated, and hence there is no relationship between HEC and HGS in elite Taekwondo athletes. The results obtained may benefit Taekwondo coaches and athletes in improving their training strategies. [ABSTRACT FROM AUTHOR]

Stiff knee gait (SKG) occurrence after a stroke is associated with various abnormal muscle activities; however, the interactions among these muscles are unclear. This study aimed to elucidate the muscle synergy characteristics during walking in patients with SKG after a stroke. This cross-sectional study included 20 patients with poststroke SKG (SKG group), 16 patients without poststroke SKG (non-SKG group), and 15 healthy adults (control group). Participants walked a 10-m distance at a comfortable speed, and electromyographic data were recorded from six lower-limb muscles. Non-negative matrix factorization was employed to derive time-varying activity (C), muscle weights (W), and the percentage of total variance accounted for (tVAF) for muscle synergies. The SKG group showed a higher tVAF than the control group. The initial stance module (including knee extensors) showed increased activity during the swing phase. The initial swing module (including hip flexors and ankle dorsiflexors) exhibited a higher activity during the single-support phase but a lower activity during the swing phase. The synergy structure in patients with SKG after stroke was simplified, with specific abnormalities in synergy activities. SKG may arise from several synergy alterations involving multiple muscles, indicating that approaches focused on controlling individual muscle activities are unsuitable. [ABSTRACT FROM AUTHOR]

Arm swing is an inherent aspect of human locomotion that enhances lower limb (LL) muscle activation, which may explain its benefits for stroke rehabilitation over fixed-arm approaches. This study analyzed how restricting arm movement affects LL muscle coordination by comparing treadmill walking with arms (WWA) and walking with no arms (WNA) through muscle synergy analysis. Surface electromyography was recorded from eight LL muscles in ten healthy participants. Significant differences were found in muscle activity envelopes at 50% of the gait cycle (GC) for the Gluteus Medius, 0% and 100% GC for the Vastus Lateralis and Semitendinosus, and 25% GC for the Semitendinosus, Gastrocnemius Medialis, and Soleus. The Rectus Femoris and Vastus Lateralis showed higher variability and activation in WNA compared to WWA. Synergy analysis revealed four muscle synergies, with a median global variance of 95%. While spatial components were similar, temporal differences emerged at 0% GC for Synergy 1, 5% and 90% GC for Synergy 2, and 95% GC for Synergy 3 (p < 0.05). Our results suggest that arm swing influences LL muscle activity and coordination during walking. Future studies will aim at understanding the effects of arm swing in stroke rehabilitation, which could help design more effective gait rehabilitation protocols including arm swing.

Treadmill-based repeated perturbation training (PBT) induces motor adaptation in reactive balance responses, thus lowering the risk of slip-induced falls. However, little evidence exists regarding intervention-induced changes in neuromuscular control underlying motor adaptation. Examining neuromuscular changes could be an important step in identifying key elements of adaptation and evaluating treadmill training protocols for fall prevention. Moreover, identifying the muscle synergies contributing to motor adaptation in young adults could lay the groundwork for comparison with high fall-risk populations. Thus, we aimed to investigate neuromuscular changes in reactive balance responses during stance slip-PBT. Lower limb electromyography (EMG) signals (4/leg) were recorded during ten repeated forward stance (slip-like) perturbations in twenty-six young adults. Muscle synergies were compared between early-training (slips 1-2) and late-training (slips 9-10) stages. Results showed that 5 different modes of synergies (named on dominant muscles: WTA, W $_{\text {S}\_{\text {VL}\text {AT}}}$ , W $_{\text {R}\_{\text {GA}\text {S}}}$ , W $_{\text {R}\_{\text {VL}\text {AT}}}$ , and W $_{\text {S}\_{\text {GA}\text {S}}}\text {)}$ were recruited in both stages. 3 out of 5 synergies (WTA, W $_{\text {R}\_{\text {VL}\text {AT}}}$ , and W $_{\text {S}\_{\text {GA}\text {S}}}\text {)}$ showed a high similarity (r >0.97) in structure and activation between stages, whereas W $_{\text {R}\_{\text {GA}\text {S}}}$ and W $_{\text {S}\_{\text {VL}\text {AT}}}$ showed a lower similarity (r $_{\text {R}\_{\text {VL}\text {AT}}}$ and the activation onset in W $_{\text {R}\_{\text {GA}\text {S}}}$ showed a reduction from early- to late-training stage (p

Lumbar exoskeleton has potential to assist in lumbar movements and thereby prevent impairment of back muscles. However, due to limitations of evaluation tools, the effect of lumbar exoskeletons on coordinated activities of back muscles is seldom investigated. This study used the surface electromyography (sEMG) topographic map based on multi-channel electrodes from low back muscles to analyze the effects. Thirteen subjects conducted two tasks, namely lifting and holding a 20kg-weight box. For each task, three different trials, not wearing exoskeleton (NoExo), wearing exoskeleton but power-off (OffExo), and wearing exoskeleton and power-on (OnExo), were randomly conducted. Root-mean-square (RMS) and median-frequency (MDF) topographic maps of the recorded sEMG were constructed. Three parameters, average pixel values, distribution of center of gravity (CoG), and entropy, were extracted from the maps to assess the muscle coordinated activities. In the lifting task, results showed the average pixel values of RMS maps for the NoExo trial were lower than those for the OffExo trial ( $\text{p} < 0.05$ ) but the same as those for the OnExo trial ( $\text{p}>$ 0.05). The distribution of CoG showed a significant difference between NoExo and OnExo trials ( $\text{p} < 0.05$ ). In the holding task, RMS and MDF maps’ average pixel values showed significant differences between NoExo and OnExo trials ( $\text{p} < 0.05$ ). These findings suggest that active lumbar exoskeletons can reduce the load on low back muscles in the static holding task rather than in the dynamic lifting task. This proves sEMG topographic maps offer a new way to evaluate such effects, thereby helping improve the design of lumbar exoskeleton systems.

Coordinated contraction of skeletal muscles relies on selective connections between the muscles and multiple classes of the spinal motoneurons. However, current research on the spatial location of the spinal motoneurons innervating different muscles is limited. In this study, we investigated the spatial distribution and relative position of different motoneurons that control the deep muscles of the mouse hindlimbs, which were innervated by the obturator nerve, femoral nerve, inferior gluteal nerve, deep peroneal nerve, and tibial nerve. Locations were visualized by combining a multiplex retrograde tracking technique compatible with three-dimensional imaging of solvent-cleared organs (3DISCO) and 3-D imaging technology based on lightsheet fluorescence microscopy (LSFM). Additionally, we propose the hypothesis that “messenger zones” exist as interlaced areas between the motoneuron pools that dominate the synergistic or antagonist muscle groups. We hypothesize that these interlaced neurons may participate in muscle coordination as messenger neurons. Analysis revealed the precise mutual positional relationships among the many motoneurons that innervate different deep muscles of the mouse. Not only do these findings update and supplement our knowledge regarding the overall spatial layout of spinal motoneurons that control mouse limb muscles, but they also provide insights into the mechanisms through which muscle activity is coordinated and the architecture of motor circuits.

Surface Electromyography (sEMG) signals are widely used as input to control robotic devices, prosthetic limbs, exoskeletons, among other devices, and provide information about someone’s intention to perform a particular movement. However, the redundant action of 32 muscles in the forearm and hand means that the neuromotor system can select different combinations of muscular activities to perform the same grasp, and these combinations could differ among subjects, and even among the trials done by the same subject. In this work, 22 healthy subjects performed seven representative grasp types (the most commonly used). sEMG signals were recorded from seven representative forearm spots identified in a previous work. Intra- and intersubject variability are presented by using four sEMG characteristics: muscle activity, zero crossing, enhanced wavelength and enhanced mean absolute value. The results confirmed the presence of both intra- and intersubject variability, which evidences the existence of distinct, yet limited, muscle patterns while executing the same grasp. This work underscores the importance of utilizing diverse combinations of sEMG features or characteristics of various natures, such as time-domain or frequency-domain, and it is the first work to observe the effect of considering different muscular patterns during grasps execution. This approach is applicable for fine-tuning the control settings of current sEMG devices.

Using a machine learning algorithm, individuals can be accurately identified from their muscle activation patterns during gait, leading to the concept of individual muscle activation signatures. Are muscle activation signatures robust across different walking speeds? We used an open dataset containing electromyographic (EMG) signals from 8 lower limb muscles in 50 asymptomatic adults walking at 5 speeds (extremely slow, very slow, slow, spontaneous, and fast). A machine learning approach classified the EMG profiles based on similar (intra-speed classification) or different (inter-speed classification) walking speeds as training and testing conditions. Intra-speed median classification rates of muscle activation profiles increased with walking speed, from 92 % for extremely slow, to 100 % for self-selected fast walking conditions. Inter-speed median classification rates increased when the speed of the training condition was closer to that of the testing condition. Higher median classification rates were found across slow, spontaneous, and fast walking speed conditions, from 56 % to 96 %, compared with classification rates involving extremely and very slow walking speed conditions, from 6 % to 62 %. Our findings reveal that i) muscle activation signatures are detectable for a large range of walking speeds, even those involving different gait strategies (intra-speed median classification rates from 92 % to 100 %), and ii) muscle activation signatures observed during very low walking speeds are not consistent with those observed at higher speeds, suggesting a difference in motor control strategy. Caution should therefore be exercised when assessing gait deviations of a slow walking patient against a normative database obtained at higher speed. Identifying the robustness of individual muscle activation signatures across different movements could help in detecting changes in motor control, otherwise difficult to detect on classical time-varying EMG patterns. • Signatures are distinctive patterns by which an individual can be identified. • Individual muscle activation signatures are revealed using EMG patterns during gait. • Muscle activation signatures are detectable for a large range of walking speeds. • Muscle activation signatures are consistent across low to high walking speeds. • A change in motor control occurs around the walking speed threshold of 0.6 m/s. [ABSTRACT FROM AUTHOR]

Treadmill-based repeated perturbation training (PBT) induces motor adaptation in reactive balance responses, thus lowering the risk of slip-induced falls. However, little evidence exists regarding intervention-induced changes in neuromuscular control underlying motor adaptation. Examining neuromuscular changes could be an important step in identifying key elements of adaptation and evaluating treadmill training protocols for fall prevention. Moreover, identifying the muscle synergies contributing to motor adaptation in young adults could lay the groundwork for comparison with high fall-risk populations. Thus, we aimed to investigate neuromuscular changes in reactive balance responses during stance slip-PBT. Lower limb electromyography (EMG) signals (4/leg) were recorded during ten repeated forward stance (slip-like) perturbations in twenty-six young adults. Muscle synergies were compared between early-training (slips 1-2) and late-training (slips 9-10) stages. Results showed that 5 different modes of synergies (named on dominant muscles: WTA, W $_{\text {S}\_{\text {VL}\text {AT}}}$ , W $_{\text {R}\_{\text {GA}\text {S}}}$ , W $_{\text {R}\_{\text {VL}\text {AT}}}$ , and W $_{\text {S}\_{\text {GA}\text {S}}}\text {)}$ were recruited in both stages. 3 out of 5 synergies (WTA, W $_{\text {R}\_{\text {VL}\text {AT}}}$ , and W $_{\text {S}\_{\text {GA}\text {S}}}\text {)}$ showed a high similarity (r >0.97) in structure and activation between stages, whereas W $_{\text {R}\_{\text {GA}\text {S}}}$ and W $_{\text {S}\_{\text {VL}\text {AT}}}$ showed a lower similarity (r <0.83) between the two stages, and the area of activation in WTA, the peak value of activation in W $_{\text {R}\_{\text {VL}\text {AT}}}$ and the activation onset in W $_{\text {R}\_{\text {GA}\text {S}}}$ showed a reduction from early- to late-training stage (p <0.05). These results suggest that a block of stance slip-PBT resulted in modest changes in muscle synergies in young adults, which might explain the smaller changes seen in biomechanical variables. Future studies should examine neuromuscular changes in people at high risk of falls. [ABSTRACT FROM AUTHOR]

Surface Electromyography (sEMG) signals are widely used as input to control robotic devices, prosthetic limbs, exoskeletons, among other devices, and provide information about someone’s intention to perform a particular movement. However, the redundant action of 32 muscles in the forearm and hand means that the neuromotor system can select different combinations of muscular activities to perform the same grasp, and these combinations could differ among subjects, and even among the trials done by the same subject. In this work, 22 healthy subjects performed seven representative grasp types (the most commonly used). sEMG signals were recorded from seven representative forearm spots identified in a previous work. Intra- and intersubject variability are presented by using four sEMG characteristics: muscle activity, zero crossing, enhanced wavelength and enhanced mean absolute value. The results confirmed the presence of both intra- and intersubject variability, which evidences the existence of distinct, yet limited, muscle patterns while executing the same grasp. This work underscores the importance of utilizing diverse combinations of sEMG features or characteristics of various natures, such as time-domain or frequency-domain, and it is the first work to observe the effect of considering different muscular patterns during grasps execution. This approach is applicable for fine-tuning the control settings of current sEMG devices. [ABSTRACT FROM AUTHOR]

Lumbar exoskeleton has potential to assist in lumbar movements and thereby prevent impairment of back muscles. However, due to limitations of evaluation tools, the effect of lumbar exoskeletons on coordinated activities of back muscles is seldom investigated. This study used the surface electromyography (sEMG) topographic map based on multi-channel electrodes from low back muscles to analyze the effects. Thirteen subjects conducted two tasks, namely lifting and holding a 20kg-weight box. For each task, three different trials, not wearing exoskeleton (NoExo), wearing exoskeleton but power-off (OffExo), and wearing exoskeleton and power-on (OnExo), were randomly conducted. Root-mean-square (RMS) and median-frequency (MDF) topographic maps of the recorded sEMG were constructed. Three parameters, average pixel values, distribution of center of gravity (CoG), and entropy, were extracted from the maps to assess the muscle coordinated activities. In the lifting task, results showed the average pixel values of RMS maps for the NoExo trial were lower than those for the OffExo trial ($\text{p} < 0.05$) but the same as those for the OnExo trial ($\text{p}>$ 0.05). The distribution of CoG showed a significant difference between NoExo and OnExo trials ($\text{p} < 0.05$). In the holding task, RMS and MDF maps’ average pixel values showed significant differences between NoExo and OnExo trials ($\text{p} < 0.05$). These findings suggest that active lumbar exoskeletons can reduce the load on low back muscles in the static holding task rather than in the dynamic lifting task. This proves sEMG topographic maps offer a new way to evaluate such effects, thereby helping improve the design of lumbar exoskeleton systems. [ABSTRACT FROM AUTHOR]

Muscle fatigue is a complex phenomenon that is influenced by the type of activity performed and often manifests as a decline in motor performance (mechanical failure). The purpose of our study was to investigate the compensatory strategies used to mitigate mechanical failure. A cohort of 21 swimmers underwent a front-crawl swimming task, which required the consistent maintenance of a constant speed for the maximum duration. The evaluation included three phases: non-fatigue, pre-mechanical failure, and mechanical failure. We quantified key kinematic metrics, including velocity, distance travelled, stroke frequency, stroke length, and stroke index. In addition, electromyographic (EMG) metrics, including the Root-Mean-Square amplitude and Mean Frequency of the EMG power spectrum, were obtained for 12 muscles to examine the electrical manifestations of muscle fatigue. Between the first and second phases, the athletes covered a distance of 919.38 ± 147.29 m at an average speed of 1.57 ± 0.08 m/s with an average muscle fatigue level of 12%. Almost all evaluated muscles showed a significant increase (p < 0.001) in their EMG activity, except for the latissimus dorsi, which showed a 17% reduction (ES 0.906, p < 0.001) during the push phase of the stroke cycle. Kinematic parameters showed a 6% decrease in stroke length (ES 0.948, p < 0.001), which was counteracted by a 7% increase in stroke frequency (ES −0.931, p < 0.001). Notably, the stroke index also decreased by 6% (ES 0.965, p < 0.001). In the third phase, characterised by the loss of the ability to maintain the predetermined rhythm, both EMG and kinematic parameters showed reductions compared to the previous two phases. Swimmers employed common compensatory strategies for coping with fatigue; however, the ability to maintain a predetermined motor output proved to be limited at certain levels of fatigue and loss of swimming efficiency (Protocol ID: NCT06069440). [ABSTRACT FROM AUTHOR]

Background: An alteration in the force distribution among quadriceps heads is one possible underlying mechanism of patellofemoral pain. However, this hypothesis cannot be directly tested as there are currently no noninvasive experimental techniques to measure individual muscle force or torque in vivo in humans. In this study, the authors considered a combination of biomechanical and muscle activation measures, which enabled us to estimate the mechanical impact of the vastus medialis (VM) and vastus lateralis (VL) on the patella. Purpose/Hypothesis: The purpose of this study was to determine whether the relative index of torque distribution for the VM and VL differs between adolescents with and without patellofemoral pain. It was hypothesized that, relative to the VL, the VM would contribute less to knee extension torque in adolescents with patellofemoral pain compared with controls. Study Design: Cross-sectional study; Level of evidence, 3. Methods: Twenty adolescents with patellofemoral pain and 20 matched control participants were included (38 female; age, 15.3 ± 1.8 years; weight, 58 ± 13 kg; height, 164 ± 8 cm). Muscle volumes and resting moment arms were quantified from magnetic resonance images, and fascicle lengths were obtained from panoramic B-mode ultrasonography. Muscle activation was estimated using surface electromyography during submaximal isometric tasks (wall-squat and seated tasks). Muscle torque was estimated as the product of muscle physiological cross-sectional area (ie, muscle volume/fascicle length), muscle activation (normalized to maximal activation), and moment arm. Results: Across tasks and force levels, the relative contribution of the VM to the overall medial and lateral vastii torque was 31.0% ± 8.6% for controls and 31.5 ± 7.6% for adolescents with patellofemoral pain (group effect, P >.34). Conclusion: For the tasks and positions investigated in this study, the authors found no evidence of lower VM torque generation (relative to the VL) in adolescents with patellofemoral pain compared with controls. [ABSTRACT FROM AUTHOR]

IntroductionAn imbalance of vastus medialis (VM) and vastus lateralis (VL) muscle activation and patterns of dyscoordination may contribute to the sex discrepancy in the incidence of patellofemoral pain syndrome (PFPS). While some studies have examined sex-specific VM/VL coordination strategies in some tasks, no previous studies have examined sex-specific VM/VL coordination strategies during repeated sprint exercise (RSE).MethodsIn this study, asymptomatic young adults (N = 39, 19 females) completed a RSE protocol consisting of 10 × 10 s all-out cycling interspersed by 30 s of passive rest. Electromyographic (EMG) signals from the VM and VL muscles were recorded throughout exercise.ResultsVM:VL ratio did not change with fatigue and was not different between the sexes. From sprint 1 to 10, VM-VL onset delay increased from 9.62 to 16.95 ms and from 19.28 to 45.09 ms in males and females, respectively (p < 0.001); however, no sex difference was found (p = 0.524). Muscle activation amplitude plateaued at different sprint repetitions in males and females while mechanical work plateaued at similar repetitions.DiscussionThese findings suggest that sex differences in the incidence of PFPS may not be influenced by VM/VL muscle coordination as assessed by EMG.

This study aimed to determine the relationship between the torque-generating capacity in sprint cycling and the strength capacity of the six lower-limb muscle groups in male and female world-class sprint cyclists. Eleven female and fifteen male top-elite cyclists performed 5-s sprints at maximal power in seated and standing positions. They also performed a set of maximal voluntary ankle, knee and hip flexions and extensions to assess single-joint isometric and isokinetic torques. Isokinetic torques presented stronger correlations with cycling torque than isometric torques for both body positions, regardless of the group. In the female group, knee extension and hip flexion torques accounted for 81.2% of the variance in cycling torque, while the ability to predict cycling torque was less evident in males (i.e., 59% of variance explained by the plantarflexion torque only). The standing condition showed higher correlations than seated and a better predictive model in males (R2 = 0.88). In addition to the knee extensors and flexors and hip extensors, main power producers, the strength capacity of lower-limb distal plantarflexor (and to a lesser extent dorsiflexor) muscles, as well as other non-measured qualities (e.g., the upper body), might be determinants to produce such extremely high cycling torque in males. [ABSTRACT FROM AUTHOR]

Muscle synergies are extensively studied to understand how the neuromusculoskeletal system deals with abundance. The synergies represent covariant muscles that act as building blocks for movement production. Nevertheless, little is known on how those synergies evolve after training, learning, and expertise. To this aim, this study reports the influence of 4-wk upper limb submaximal training with arm cranking on novice participants' muscle synergies. Twelve participants performed eight sessions of submaximal training for 4 wk. One session consisted of two 30-s maximal power tests followed by six 2-min bouts at 30% of maximal recorded power. Cranking torque and electromyogram (EMG) of 11 representative muscles were recorded during the entire protocol. After EMG normalization, muscle synergies were extracted with nonnegative matrix factorization (NNMF). Similarity was computed with cross correlation and cosine similarities, and statistical evolution across training days was tested by repeated-measures ANOVA. Although maximal power increased across training days, neither torque management, EMG, nor muscle synergies (4 synergies) were significantly affected by submaximal training. Nevertheless, results suggest slight modifications of muscle synergies across days despite nonsignificant differences. Despite the strong complexity of the upper limb anatomy, our results showed that training did not induce significant changes in movement realization (mechanical and coordination level). A low-dimensional organization of covariant muscles (muscle synergies) is selected from the first day and maintained through the following training days, despite slight but nonsignificant modifications. This study supports the hypothesis that motor control for movement production could be simplified by using low-dimensional building blocks (muscle synergies). Such building blocks allow stability in movement execution and are slightly adjusted to fit movement requirements with training. [ABSTRACT FROM AUTHOR]

• Wavelet pooled scalogram is introduced to assess coactivation of multiple muscles. • The pooled scalogram characterizes EMG-signal content in time-frequency domain. • Significant invariants are extracted by NMF to assess time-frequency features. • Shared invariants among subjects hint physiological features in frequency domain. • This approach may improve the investigation on motor control and neural diseases. Different approaches based on surface electromyographic signals (EMG) were proposed to understand the interplay among several muscles, most of which were based on the solely EMG amplitude and neglected spectral characteristics. This study introduced an approach that quantitatively characterizes the co-activation of multiple muscles in time-frequency domain, based on the continuous wavelet transform (CWT). The pooled scalogram, defined here as the CWT-based cross-energy localization of multiple EMG signals, quantified the co-activation among several muscles in time-frequency domain. Algorithm performances were tested on 30,000 synthetic EMG signals, with different signal-to-noise ratio. Experimental sEMG were recorded from tibialis anterior, gastrocnemius lateralis, and vastus lateralis during walking of 31 young healthy subjects. Significant invariants were extracted by Non-Negative Matrix Factorization Analysis to determine time-frequency invariants. The proposed CWT approach provided an accurate prediction of co-activation timing in the synthetic signal. Analysis of experimental signals indicated population consistency in time-frequency invariants and showed that muscular co-contraction peak was identified in heel strike and in the Piper frequency band. Synthetic data demonstrated the capability of the pooled scalogram to accurately detect the timings among multiple signals. Experimental analysis suggested that when TA, GL, and VL are co-active over time, they also synchronized in frequency within the Piper band. The pooled scalogram will lead to a better understanding of the control laws underlying the motor coordination, and it could represent a marker of neurological pathologies or a quantitative evaluation of the effects of a rehabilitative process. [ABSTRACT FROM AUTHOR]

Shoulder elevation, defined here as arm raising, being essential for activities of daily living, dysfunctions represent a substantial burden in patients' lives. Owing to the complexity of the shoulder joint, the tightly coordinated muscular activity is a fundamental component, and neuromuscular impairments have devastating effects. A single-joint shoulder type version of the Hybrid Assistive Limb (HAL) allowing motion assistance based on the intention of the user via myoelectric activation has recently been developed, and its safety was demonstrated for shoulder rehabilitation. Yet, little is known about the physiological effects of the device. This study aims to monitor the changes in muscle activity and motion during shoulder HAL rehabilitation in several patients suffering from shoulder elevation dysfunction from cervical radicular origin. 8 patients (6 males, 2 females, mean age 62.4 &#177 9.3 years old) with weakness of the deltoid muscle resulting from a damage to the C5 nerve root underwent HAL-assisted rehabilitation. We combined surface electromyography and three-dimensional motion capture to record muscular activity and kinematics. All participants showed functional recovery, with improvements in their Manual Muscle Testing (MMT) scores and range of motion (ROM). During training, HAL decreased the activity of deltoid and trapezius, significantly more for the latter, as well as the coactivation of both muscles. We also report a reduction of the characteristic shrugging compensatory motion which is an obstacle to functional recovery. This reduction was notably demonstrated by a stronger reliance on the deltoid rather than the trapezius, indicating a muscle coordination tending toward a pattern similar to healthy individuals. Altogether, the results of the evaluation of motion and muscular changes hint toward a functional recovery in acute, and chronic shoulder impairments from cervical radicular origin following shoulder HAL rehabilitation training and provide information on the physiological effect of the device. [ABSTRACT FROM AUTHOR]

Flying insects solve a daunting control problem of generating a patterned and precise motor program to stay airborne and generate agile maneuvers. In this motor program, each muscle encodes information about movement in precise spike timing down to the millisecond scale. Whereas individual muscles share information about movement, we do not know whether they have separable effects on an animal's motion, or whether muscles functionally interact such that the effects of any muscle's timing depend heavily on the state of the entire musculature. To answer these questions, we performed spike-resolution electromyography and electrical stimulation in the hawkmoth Manduca sexta during tethered flapping. We specifically explored how flight power muscles contribute to pitch control. Combining correlational study of visually induced turns with causal manipulation of spike timing, we discovered likely coordination patterns for pitch turns, and investigated whether these patterns can drive pitch control. We observed significant timing change of the main downstroke muscles, the dorsolongitudinal muscles (DLMs), associated with pitch turns. Causally inducing this timing change in the DLMs with electrical stimulation produced a consistent, mechanically relevant feature in pitch torque, establishing that power muscles in M. sexta have a control role in pitch. Because changes were evoked in only the DLMs, however, these pitch torque features left large unexplained variation. We found this unexplained variation indicates significant functional overlap in pitch control such that precise timing of one power muscle does not produce a precise turn, demonstrating the importance of coordination across the entire motor program for flight., Competing Interests: Competing interests The authors declare no competing or financial interests., (© 2024. Published by The Company of Biologists Ltd.)

Shoulder elevation, defined here as arm raising, being essential for activities of daily living, dysfunctions represent a substantial burden in patients’ lives. Owing to the complexity of the shoulder joint, the tightly coordinated muscular activity is a fundamental component, and neuromuscular impairments have devastating effects. A single-joint shoulder type version of the Hybrid Assistive Limb (HAL) allowing motion assistance based on the intention of the user via myoelectric activation has recently been developed, and its safety was demonstrated for shoulder rehabilitation. Yet, little is known about the physiological effects of the device. This study aims to monitor the changes in muscle activity and motion during shoulder HAL rehabilitation in several patients suffering from shoulder elevation dysfunction from cervical radicular origin. 8 patients (6 males, 2 females, mean age 62.4 ± 9.3 years old) with weakness of the deltoid muscle resulting from a damage to the C5 nerve root underwent HAL-assisted rehabilitation. We combined surface electromyography and three-dimensional motion capture to record muscular activity and kinematics. All participants showed functional recovery, with improvements in their Manual Muscle Testing (MMT) scores and range of motion (ROM). During training, HAL decreased the activity of deltoid and trapezius, significantly more for the latter, as well as the coactivation of both muscles. We also report a reduction of the characteristic shrugging compensatory motion which is an obstacle to functional recovery. This reduction was notably demonstrated by a stronger reliance on the deltoid rather than the trapezius, indicating a muscle coordination tending toward a pattern similar to healthy individuals. Altogether, the results of the evaluation of motion and muscular changes hint toward a functional recovery in acute, and chronic shoulder impairments from cervical radicular origin following shoulder HAL rehabilitation training and provide information on the physiological effect of the device.

Background: Achilles tendinopathy (AT) may affect ground reaction force (GRF) and muscle synergy (MS) during walking due to pain, biological integrity changes in the tendon and neuroplastic adaptations. The objective of this study was to compare GRF asymmetries and MS attributes between symptomatic and asymptomatic lower limbs (LL) during walking at natural and fast speeds in adults with unilateral AT. Methods: A convenience sample consisting of twenty-eight participants walked on an instrumented treadmill at natural (1.3 m/s) and fast (1.6 m/s) speeds. Peak GRF were measured in mediolateral, anteroposterior and vertical directions. Individualized electromyography (EMG) activation profiles were time- and amplitude-normalized for three consecutive gait cycles and MS were extracted using non-negative matrix factorization algorithms. MS were characterized by the number, composition (i.e., weighting of each muscle) and temporal profiles (i.e., duration and amplitude) of the MS extracted during walking. Paired Student's t-tests assessed peak GRF and MS muscle weighting differences between sides whereas Pearson correlation coefficients characterized the similarities of the individualized EMG and MS activation temporal profiles within sides. Results: AT had limited effects on peak GRF asymmetries and the number, composition and temporal profiles of MS between symptomatic and asymptomatic LL while walking on a level treadmill at natural and fast speeds. In most participants, four MS with a specific set of predominantly activated muscles were extracted across natural (71 and 61%) and fast (54 and 50%) walking speeds for the symptomatic and asymptomatic side respectively. Individualized EMG activation profiles were relatively similar between sides (r = 0.970 to 0.999). As for MS attributes, relatively similar temporal activation profiles (r = 0.988 to 0.998) and muscle weightings (p < 0.05) were found between sides for all four MS and the most solicited muscles. Although the faster walking speed increased the number of merged MS for both sides, it did not significantly alter MS symmetry. Conclusion: Faster walking speed increased peak GRF values but had limited effects on GRF symmetries and MS attribute differences between the LL. Corticospinal neuroplastic adaptations associated with chronic unilateral AT may explain the preserved quasi-symmetric LL motor control strategy observed during natural and fast walking among adults with chronic unilateral AT. [ABSTRACT FROM AUTHOR]

Large inter‐individual variability of activation strategies is observed during hamstring strengthening exercises but their consequences remain unexplored. The objective of this study was to determine whether individual activation strategies are related to the distribution of damage across the hamstring muscle heads semimembranosus (SM), semitendinosus (ST), and biceps femoris (BF) after eccentric contractions. 24 participants performed 5 sets of 15 maximal eccentric contractions of knee flexors on a dynamometer, while activation of each muscle head was assessed using surface electromyography. Knee flexion maximal isometric strength was assessed before exercise and 48 h afterward. Shear modulus was measured using shear wave elastography before exercise and 30 min afterward to quantify the distribution of damage across the hamstring muscle heads. At 48 h, maximal knee flexion torque had decreased by 15.9% ± 16.9% (p < 0.001). Although no differences between activation ratios of each muscle were found during the eccentric exercise (all p > 0.364), we reported a heterogeneous distribution of damage, with a larger change in shear modulus of ST/Hams than SM/Hams (+70.8%, p < 0.001) or BF/Hams (+50.3%, p < 0.001). A large correlation was found between the distribution of activation and the distribution of damage for ST/Hams (r = 0.69; p < 001). This study provides evidence that the distribution of activation during maximal eccentric contractions has mechanical consequences for synergist muscles. Further studies are needed to understand whether individual activation strategies influence the distribution of structural adaptations after a training program. [ABSTRACT FROM AUTHOR]

Recent advances in the performance and evaluation of walking in exoskeletons use various assessments based on kinematic/kinetic measurements. While such variables provide general characteristics of gait performance, only limited conclusions can be made about the neural control strategies. Moreover, some kinematic or kinetic parameters are a consequence of the control implemented on the exoskeleton. Therefore, standard indicators based on kinematic variables have limitations and need to be complemented by performance measures of muscle coordination and control strategy. Knowledge about what happens at the spinal cord output level might also be critical for rehabilitation since an abnormal spatiotemporal integration of activity in specific spinal segments may result in a risk for abnormalities in gait recovery. Here we present the PEPATO software, which is a benchmarking solution to assess changes in the spinal locomotor output during walking in the exoskeleton with respect to reference data on normal walking. In particular, functional and structural changes at the spinal cord level can be mapped into muscle synergies and spinal maps of motoneuron activity. A user-friendly software interface guides the user through several data processing steps leading to a set of performance indicators as output. We present an example of the usage of this software for evaluating walking in an unloading exoskeleton that allows a person to step in simulated reduced (the Moon's) gravity. By analyzing the EMG activity from lower limb muscles, the algorithms detected several performance indicators demonstrating differential adaptation (shifts in the center of activity, prolonged activation) of specific muscle activation modules and spinal motor pools and increased coactivation of lumbar and sacral segments. The software is integrated at EUROBENCH facilities to benchmark the performance of walking in the exoskeleton from the point of view of changes in the spinal locomotor output. [ABSTRACT FROM AUTHOR]

We investigated the effect of low and high bar velocity on inter- and intrasubject similarity of muscle synergies during bench press. A total of 13 trained male subjects underwent two exercise conditions: a slow- and a fast-velocity bench press. Surface electromyography was recorded from 13 muscles, and muscle synergies were extracted using a nonnegative matrix factorization algorithm. The intrasubject similarity across conditions and intersubject similarity within conditions were computed for muscle synergy vectors and activation coefficients. Two muscle synergies were sufficient to describe the dataset variability. For the second synergy activation coefficient, the intersubject similarity within the fast-velocity condition was greater than the intrasubject similarity of the activation coefficient across the conditions. An opposite pattern was observed for the first muscle synergy vector. We concluded that the activation coefficients are robust within conditions, indicating a robust temporal pattern of muscular activity across individuals, but the muscle synergy vector seemed to be individually assigned. [ABSTRACT FROM AUTHOR]

Purpose: The human neuro-motor system can select different intermuscular coordination patterns to complete any given task, such as pedalling a bicycle. This study assessed whether intermuscular coordination patterns are used consistently across visit days and cadence conditions in recreationally active individuals. Methods: Seven participants completed a cycling exercise protocol across 2 days, consisting of pedalling at 150 Watts at cadences of 60, 80 and 100 rpm. Whilst cycling, surface electromyography was continuously recorded from ten leg muscles. For each participant, muscle coordination patterns were established using principal component (PC) analysis and the amount that each pattern was used was quantified by the PC loading scores. A sample entropy derived measure of the persistence of the loading scores across consecutive pedal cycles, entropic half-life (EnHL), was calculated. The median loading scores and EnHLs of the first three PCs were then compared across cadence conditions and visit days. Results: No significant differences were found in the median loading scores across cadence conditions or visits, nor were there any significant differences in the EnHLs across visits. However, the EnHLs were significantly longer when participants were cycling at 60 rpm compared to 100 rpm. Conclusion: These findings are based on a small sample size, but do suggest that, within individual participants, a consistent neuromuscular control strategy is used during cycling on different days. However, the underlying structure of muscle coordination is more persistent when pedalling at slower cadences with large differences between individuals. [ABSTRACT FROM AUTHOR]

Background. Upper (UL) and lower limb (LL) cycling is extensively used for several applications, especially for rehabilitation for which neuromuscular interactions between UL and LL have been shown. Nevertheless, the knowledge on the muscular coordination modality for UL is poorly investigated and it is still not known whether those mechanisms are similar or different to those of LL. The aim of this study was thus to put in evidence common coordination mechanism between UL and LL during cycling by investigating the mechanical output and the underlying muscle coordination using synergy analysis. Methods. Twenty-five revolutions were analyzed for six non-experts' participants during sub-maximal cycling with UL or LL. Crank torque and muscle activity of eleven muscles UL or LL were recorded. Muscle synergies were extracted using nonnegative matrix factorization (NNMF) and group- and subject-specific analysis were conducted. Results. Four synergies were extracted for both UL and LL. UL muscle coordination was organized around several mechanical functions (pushing, downing, and pulling) with a proportion of propulsive torque almost 80% of the total revolution while LL muscle coordination was organized around a main function (pushing) during the first half of the cycling revolution. LL muscle coordination was robust between participants while UL presented higher interindividual variability. Discussion. We showed that a same principle of muscle coordination exists for UL during cycling but with more complex mechanical implications. This study also brings further results suggesting each individual has unique muscle signature. [ABSTRACT FROM AUTHOR]

Abstract Background Epigallocatechin gallate (EGCG) acts as an antioxidant by preventing oxidative stress. The effect of EGCG on aluminum-induced testicular injury is not clear. Hence, the present study is planned to investigate the effect of EGCG on aluminum chloride (AlCl3)-induced changes in behavior, biochemical parameters, and spermatogenesis in male Sprague-Dawley rats. The rats were divided into six groups with six animals each. All the animals were administered with respective assigned treatment once daily for 28 days. The animals in groups I to VI were administered with drug vehicle, AlCl3, vitamin C, EGCG, vitamin C, and EGCG, respectively. The animals in groups V and VI were additionally challenged with AlCl3 (10 mg/kg) immediately after vitamin C and EGCG administration, respectively. Changes in behavior were measured on day 1, 14 and 28. At the end of the study, the blood sample was collected from all the animals, and the serum was separated and used for biochemical analysis. Later, the rats were subjected to bilateral orchiectomy; sperm was collected from the cauda epididymis for microscopic examination. Then, the animals were sacrificed, and the organs such as the brain, lungs, heart, liver, kidney, spleen, and testis were collected for organ weight analysis. Results The animal administered with AlCl3 showed a reduction in locomotor activity, grip strength, and escape latency time whereas vitamin C prevented the effect of AlCl3. But, EGCG did not show any significant changes in AlCl3-induced behavioral and biochemical changes. At the end of the study, vitamin C prevented AlCl3-induced behavioral and biochemical changes. The group of animals administered with AlCl3 showed a reduction in the number of spermatozoa whereas AlCl3 + vitamin C and AlCl3 + EGCG did not show any significant changes in the number of spermatozoa when compared to the control group. Conclusion EGCG prevented AlCl3-induced reduction in epididymal sperm count of male rats and did not show any significant effect on AlCl3-induced changes in behavior and biochemical parameters, whereas vitamin C had an ameliorative effect on AlCl3-induced changes in behavior, biochemical parameter, and spermatogenesis. Graphical abstract

Background Upper (UL) and lower limb (LL) cycling is extensively used for several applications, especially for rehabilitation for which neuromuscular interactions between UL and LL have been shown. Nevertheless, the knowledge on the muscular coordination modality for UL is poorly investigated and it is still not known whether those mechanisms are similar or different to those of LL. The aim of this study was thus to put in evidence common coordination mechanism between UL and LL during cycling by investigating the mechanical output and the underlying muscle coordination using synergy analysis. Methods Twenty-five revolutions were analyzed for six non-experts’ participants during sub-maximal cycling with UL or LL. Crank torque and muscle activity of eleven muscles UL or LL were recorded. Muscle synergies were extracted using nonnegative matrix factorization (NNMF) and group- and subject-specific analysis were conducted. Results Four synergies were extracted for both UL and LL. UL muscle coordination was organized around several mechanical functions (pushing, downing, and pulling) with a proportion of propulsive torque almost 80% of the total revolution while LL muscle coordination was organized around a main function (pushing) during the first half of the cycling revolution. LL muscle coordination was robust between participants while UL presented higher interindividual variability. Discussion We showed that a same principle of muscle coordination exists for UL during cycling but with more complex mechanical implications. This study also brings further results suggesting each individual has unique muscle signature.

This study explains the role of muscle coordination in chopstick manipulation and investigates the effects of object width and weight on intrinsic and extrinsic hand muscle activity when picking up objects with chopsticks. Surface electromyography was used to measure the activity of the intrinsic and extrinsic hand muscles when picking up objects of varying widths and weights using chopsticks. The results revealed coordinated muscle activity patterns in the intrinsic and extrinsic hand muscles and coordination between them during chopstick manipulation. Object widths varying between 1 and 3 cm did not significantly affect muscle activity; however, object weight influenced muscle activity during both chopstick closing and object grasping, with greater muscle activity in the 40 g condition than in the 10 g condition. Intrinsic hand muscles were found to be involved in object grasping, regardless of object weight. These findings suggest that object weight should be considered when practicing picking up objects with chopsticks in scenarios resembling daily dining, to prevent excessive muscle activity during rehabilitation., (Copyright © 2024 SFCM. Published by Elsevier Masson SAS. All rights reserved.)

Abstract Moving about in the world during daily life requires executing and successfully shifting between a variety of functional tasks, such as rising from a chair or bed, walking, turning, and navigating stairs. Moreover, moving about during daily life requires not only navigating between different functional tasks, but also performing these tasks in the presence of mental distractions. However, little is known about underlying neuromuscular control for executing and shifting between these different tasks. In this study, we investigated muscle coordination across walking, turning, and chair transfers by applying motor module (a.k.a. muscle synergy) analysis to the Timed‐Up‐and‐Go (TUG) test with and without a secondary cognitive dual task. We found that healthy young adults recruit a small set of common motor modules across the subtasks of the TUG test and that their composition is robust to cognitive distraction. Instead, cognitive distraction impacted motor module activation timings such that they became more consistent. This work is the first to demonstrate motor module generalization across multiple tasks that are both functionally different and crucial for healthy mobility. Overall, our results suggest that the central nervous system may draw from a “library” of modular control strategies to navigate the variety of movements and cognitive demands required of daily life.

Moving about in the world during daily life requires executing and successfully shifting between a variety of functional tasks, such as rising from a chair or bed, walking, turning, and navigating stairs. Moreover, moving about during daily life requires not only navigating between different functional tasks, but also performing these tasks in the presence of mental distractions. However, little is known about underlying neuromuscular control for executing and shifting between these different tasks. In this study, we investigated muscle coordination across walking, turning, and chair transfers by applying motor module (a.k.a. muscle synergy) analysis to the Timed‐Up‐and‐Go (TUG) test with and without a secondary cognitive dual task. We found that healthy young adults recruit a small set of common motor modules across the subtasks of the TUG test and that their composition is robust to cognitive distraction. Instead, cognitive distraction impacted motor module activation timings such that they became more consistent. This work is the first to demonstrate motor module generalization across multiple tasks that are both functionally different and crucial for healthy mobility. Overall, our results suggest that the central nervous system may draw from a "library" of modular control strategies to navigate the variety of movements and cognitive demands required of daily life. [ABSTRACT FROM AUTHOR]

The aim of this study was to compare the distribution of activation among the three heads of the hamstring between a knee flexion-oriented exercise (Nordic hamstring) and a hip extension-oriented exercise (stiff-leg Deadlift) at the group and individual level. Data were collected for 20 participants. Muscle activation of the semimembranosus (SM), semitendinosus (ST), and biceps femoris (BF) was estimated using surface electromyography (EMG) during Nordic hamstring and stiff-leg Deadlift exercises. Although Nordic hamstring exercise induced a higher normalized RMS EMG value for BF (64.5 ± 17.4%) compared to SM (48.6 ± 14.6%; P < 0.001) and ST (55.9 ± 17.4%; P < 0.001), the greatest active muscle varied between individuals. Similar interindividual differences in the greatest active muscle were found for the stiff-leg Deadlift exercise. Regarding the distribution of activation, the stiff-leg Deadlift favoured the contribution of the SM compared to ST (P < 0.001, 18/20 participants) whereas the Nordic hamstring exercise favoured the contribution of the ST compared to SM (P < 0.001, 19/20 participants). Importantly, these tasks affected the contribution of the activation of BF in different ways between individuals. The distribution of activation across the three muscles was well correlated between the two exercises (r values ≥ 0.42). [ABSTRACT FROM AUTHOR]

Motor planning can enable integration of sensory input to generate motor execution. However, how the brain analyses visual information and modulates its signals to the muscle have been not well studied in human. The aim of this study was to investigate the dimensionality effect of myoelectric-controlled interface (MCI) on motor planning and motor execution during elbow tracking movements. Twenty right-handed healthy subjects were recruited to complete tracking tasks by modulating their biceps and triceps activation within one-dimensional and two-dimensional MCI. The electromyography (EMG) signals of the biceps and triceps was recorded to calculate the normalized muscle activation, while the functional near infrared spectroscopy (fNIRS) signals of the prefrontal cortex (PFC) and bilateral motor cortex (MC) were also collected to gain the brain activation simultaneously. The results showed that the activation of antagonist muscle was significant lower within two-dimensional MCI than that within one-dimensional MCI at the muscle level. At the brain level, it was found an obvious higher activation in the PFC and the left MC within two-dimensional MCI than that within one-dimensional MCI. The current EMG-fNIRS study confirmed that visual feedback can influence motor planning and motor execution, and the PFC and bilateral MC are the likely targeted sites of the proactive inhibition of the antagonist muscle. This study adds a new perspective to possible visual regulation of neuromuscular control, which might be an effective rehabilitation method to improve abnormal muscle coordination in the clinic.

Production of functional forces by human motor systems require coordination across multiple muscles. Grip and pinch are two prototypes for grasping force production. Each grasp plays a role in a range of hand functions and can provide an excellent paradigm for studying fine motor control. Despite previous investigations that have characterized muscle synergies during general force production, it is still unclear how intermuscular coordination differs between grip and pinch and across different force outputs. Traditional muscle synergy analyses, such as non-negative matrix factorization or principal component analysis, utilize dimensional reduction without consideration of nonlinear characteristics of muscle co-activations. In this study, we investigated the novel method of multiplex recurrence networks (MRN) to assess the inter-muscular coordination for both grip and pinch at different force levels. Unlike traditional methods, the MRN can leverage intrinsic similarities in muscle contraction dynamics and project its layers to the corresponding weighted network (WN) to better model muscle interactions. Twenty-four healthy volunteers were instructed to grip and pinch an apparatus with force production at 30%, 50%, and 70% of their respective maximal voluntary contraction (MVC). The surface electromyography (sEMG) signals were recorded from eight muscles, including intrinsic and extrinsic muscles spanning the hand and forearm. The sEMG signals were then analyzed using MRNs and WNs. Interlayer mutual information (${I}$) and average edge overlap ($\omega $) of MRNs and average shortest path length (${L}$) of WNs were computed and compared across groups for grasp types (grip vs. pinch) and force levels (30%, 50% and 70% MVC). Results showed that the extrinsic, rather than the intrinsic muscles, had significant differences in network parameters between both grasp types (${p} < 0.05$), and force levels (${p} < 0.05$), and especially at higher force levels. Furthermore, ${I}$ and $\omega $ were strengthened over time (${p} < 0.05$) except with pinch at 30% MVC. Results suggest that the central nervous system (CNS) actively increases cortical oscillations over time in response to increasing force levels and changes in force production with different sustained grasping types. Muscle coupling in extrinsic muscles was higher than in intrinsic muscles for both grip and pinch. The MRNs may be a valuable tool to provide greater insights into inter-muscular coordination patterns of clinical populations, assess neuromuscular function, or stabilize force control in prosthetic hands. [ABSTRACT FROM AUTHOR]

This study aimed to quantify the influence of an increase in power output (PO) on joint kinematics and electromyographic (EMG) activity during an incremental test to exhaustion for a population of professional cyclists. The hip flexion/extension and internal/external rotation as well as knee abduction/adduction ranges of motion were significantly decreased at 100% of the maximal aerobic power (MAP). EMG analysis revealed a significant increase in the root mean square (RMS) for all muscles from 70% of the MAP. Gastrocnemius muscles [lateralis gastrocnemius (GasL) and medialis gastrocnemius (GasM)] were the less affected by the increase of PO. Cross-correlation method showed a significant increase in the lag angle values for VM in the last stage compared to the first stage, meaning that the onset of the activation started earlier during the pedaling cycle. Statistical Parametric Mapping (SPM) demonstrated that from 70% MAP, biceps femoris (BF), tibialis anterior (TA), gluteus maximus (GM), and rectus femoris (RF) yielded larger ranges of the crank cycle on which the level of recruitment was significantly increased. This study revealed specific muscular and kinematic coordination for professional cyclists in response to PO increase.

Arm cycling is a bimanual motor task used in medical rehabilitation and in sports training. Understanding how muscle coordination changes across different biomechanical constraints in arm cycling is a step toward improved rehabilitation approaches. This exploratory study aims to get new insights on motor control during arm cycling. To achieve our main goal, we used the muscle synergies analysis to test three hypotheses: 1) body position with respect to gravity (sitting and supine) has an effect on muscle synergies; 2) the movement size (crank length) has an effect on the synergistic behavior; 3) the bimanual cranking mode (asynchronous and synchronous) requires different synergistic control. Thirteen able-bodied volunteers performed arm cranking on a custom-made device with unconnected cranks, which allowed testing three different conditions: body position (sitting vs. supine), crank length (10 cm vs. 15 cm), and cranking mode (synchronous vs. asynchronous). For each of the eight possible combinations, subjects cycled for 30 s while electromyography of eight muscles (four from each arm) were recorded: biceps brachii, triceps brachii, anterior deltoid, and posterior deltoid. Muscle synergies in this eight-dimensional muscle space were extracted by nonnegative matrix factorization. Four synergies accounted for over 90% of muscle activation variances in all conditions. Results showed that synergies were affected by body position and cranking mode but practically unaffected by movement size. These results suggest that the central nervous system may employ different motor control strategies in response to external constraints such as cranking mode and body position during arm cycling. NEW & NOTEWORTHY Recent studies analyzed muscle synergies in lower limb cycling. Here, we examine upper limb cycling and specifically the effect of body position with respect to gravity, movement size, and cranking mode on muscle coordination during arm cranking tasks. We show that altered body position and cranking mode affects modular organization of muscle activities. To our knowledge, this is the first study assessing motor control through muscle synergies framework during upper limb cycling with different constraints. [ABSTRACT FROM AUTHOR]

• We assessed the influences of postural instability on reaching preparation and execution. • Postural challenges produced adaptive changes to CoM displacement and arm kinematics. • Surprisingly, CoM displacement was similar across postures during reach acceleration phase. • Despite kinematic changes, spatial preparatory muscle activity was preserved across postures. • Preparatory postural adjustments drive a whole-body strategy necessary for movement initiation. Postural and movement components must be coordinated without significant disturbance to balance when reaching from a standing position. Traditional theories propose that muscle activity prior to movement onset create the mechanics to counteract the internal torques generated by the future limb movement, reducing possible instability via centre of mass (CoM) displacement. However, during goal-directed reach movements executed on a fixed base of support (BoS), preparatory postural adjustments (or p PAs) promote movement of the CoM within the BoS. Considering this dichotomy, the current study investigated if p PAs constitute part of a whole-body strategy that is tied to the efficient execution of movement, rather than the constraints of balance. We reasoned that if p PAs were tied primarily to balance control, they would modulate as a function of perceived instability. Alternatively, if tied to dynamics necessary for movement initiation, they would remain unchanged, with feedback-based changes being sufficient to retain balance following volitional arm movement. Participants executed beyond-arm reaching movements in four different postural configurations that altered the quality of the BoS. Quantification of these changes to stability did not drastically alter the tuning or timing of preparatory muscle activity despite modifications to arm and CoM trajectories necessary to complete the reaching movement. In contrast to traditional views, preparatory postural muscle activity is not always tuned for balance maintenance or even as a calculation of upcoming instability but may reflect a requirement of voluntary movement towards a pre-defined location. [ABSTRACT FROM AUTHOR]

The effects of lower limb (L/L) control options, developed for overground walking with a wearable robotic exoskeleton (WRE), on the neuromotor control of L/L muscles [i.e., muscle synergies (MSs)] during walking remain uncertain. To gain initial insights regarding the effects of different control options on the number of MSs at the L/L and on their muscle weighting within each MS when walking with a WRE. Twenty able-bodied adults walked overground without and with the WRE set at two control options with a predetermined foot pathway imposed by the WRE, and at three other control options with free L/L kinematics in the sagittal plane. Surface electromyography of eight right L/L muscles was recorded. MSs were extracted using a non-negative matrix factorisation algorithm. Cosine similarity and correlation coefficients characterised similarities between the MSs characteristics. Freely moving the L/L in the sagittal plane (i.e., non-trajectory controlled options) during WRE walking best duplicated typical MSs extracted when walking without WRE. Conversely, WRE walking while fully controlling the L/L trajectory presented the lowest correlations to all MSs extracted when walking without WRE, especially during early swing and L/L deceleration. Neuromotor control of L/L muscles is affected by the selected control option during WRE walking, particularly when a predetermined foot pathway is imposed. This exploratory study represents the first step in informing the decision-making process regarding the use of different L/L control options when using WRE and calls for further research among adults with sensorimotor impairments. [ABSTRACT FROM AUTHOR]

Background: Recent studies provide compelling evidence that recruiting a common pool of motor modules across behaviors (i.e., motor module generalization) may facilitate motor performance. In particular, motor module generalization across standing reactive balance and walking is associated with both walking speed and endurance in neurologically impaired populations (e.g., stroke survivors and individual's with Parkinson's disease). To test whether this phenomenon is a general neuromuscular strategy associated with well-coordinated walking and not limited to motor impairment, this relationship must be confirmed in neurologically intact adults.Research Question: Is motor module generalization across standing reactive balance and walking related to walking performance in neurologically intact young adults?Methods: Two populations of young adults were recruited to capture a wide range of walking performance: professionally-trained ballet dancers (i.e., experts, n = 12) and novices (n = 8). Motor modules (a.k.a. muscle synergies) were extracted from muscles spanning the trunk, hip, knee and ankle during walking and multidirectional perturbations to standing. Motor module generalization was calculated as the number of modules common to these behaviors. Walking performance was assessed using self-selected walking speed and beam-walking proficiency (i.e., distance walked on a narrow beam). Motor module generalization between experts and novices was compared using rank-sum tests and the association between generalization and walking performance was assessed using correlation analyses.Results: Experts generalized more motor modules across standing reactive balance and walking than novices (p = 0.009). Across all subjects, motor module generalization was moderately associated with increased beam walking proficiency (r = 0.456, p = 0.022) but not walking speed (r = 0.092, p = 0.349).Significance: Similar relationships between walking performance and motor module generalization exist in neurologically intact and impaired populations, suggesting that motor module generalization across standing reactive balance and walking may be a general neuromuscular mechanism contributing to the successful control of walking. [ABSTRACT FROM AUTHOR]

Transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) has been demonstrated to modulate the motor performance of both healthy individuals and patients with neuromuscular disorders. However, the effect of tDCS on motor control of multiple muscles, which is a prerequisite to change in motor performance, is currently unknown. Using dimensionality reduction analysis, we investigated whether bilateral tDCS over M1 modulates the coordinated activity of 12 muscles. Fifteen healthy men participated in this randomized, double-blind crossover study. Each participant received a 20-min sham and 2-mA stimulation bilaterally over M1 (anode on the right M1 and cathode on the left M1), with a minimum washout period of 4 days. Muscle activation and end-point kinematics were evaluated during a task where participants reached out to a marked target with non-dominant hand as fast as possible, before and immediately after tDCS application. We found decreased similarity in motor modularity and significant changes in muscle activation in a specific motor module, particularly when reaching out to a target placed within arm's length and improved smoothness index of movement only following 2-mA stimulation. These findings indicate that clinicians and researchers need to consider the simultaneous effect of bilateral tDCS over M1 on multiple muscles when they establish tDCS protocol to change in motor performance of patients with neuromuscular deficits. [ABSTRACT FROM AUTHOR]