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2. Efficacy & safety of glycine fortified oral rehydration solution in the treatment of acute dehydrating diarrhoea in children.

Author

Bhattacharya SK, Dutta P, Bhattacharya MK, Mukherjee HN, Dutta D, Sinha AK, Mitra U, Nashipuri JN, and Pal SC

Subjects
Child, Preschool, Humans, Infant, Male, Randomized Controlled Trials as Topic, Dehydration therapy, Diarrhea therapy, Glycine therapeutic use, Hypernatremia etiology, Rehydration Solutions therapeutic use
Abstract

Efficacy and safety of glycine fortified oral rehydration solution (ORS) was compared with a standard ORS (WHO formula) in a randomized clinical trial in children aged between 4 months and 5 yr with moderate degree of dehydration owing to acute watery diarrhoea. No significant differences (P greater than 0.05) were observed in diarrhoeal stool output, duration of diarrhoea and intake of ORS between the study and control groups respectively. Thus glycine fortified ORS does not have any additional advantage over standard ORS. Moreover, two children developed hypernatraemia after receiving glycine fortified ORS in contrast to the control group. It is therefore suggested that glycine supplemented ORS should not be prescribed for the treatment of diarrhoeal dehydration in children.

Published
1989

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