29 results on '"MONTI BRAGADIN, L."'
Search Results
2. The use of standardized incidence and prevalence rates in epidemiological studies on multiple sclerosis - A meta-analysis study
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ZIVADINOV R., IONA L., MONTI BRAGADIN L., BOSCO A., JURJEVIC A., TAUS C., CAZZATO G., ZORZON, MARINO, Zivadinov, R., Iona, L., MONTI BRAGADIN, L., Bosco, A., Jurjevic, A., Taus, C., Cazzato, G., and Zorzon, Marino
- Subjects
multiple sclerosis ,prevalence ,incid ,standardization ,meta-analysis - Abstract
The crude incidence and prevalence rates in epidemiological studies on MS should be age and sex adjusted to a common standard population to permit a more reliable comparison among studies performed in different countries.Our findings support the opinion that the latitude does not play a key role in determining the onset of MS.
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- 2003
3. A longitudinal study of brain atrophy and cognitive disturbances in early phase of relapsing-remitting multiple sclerosis
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Zivadinov, R., Sepcic, J., Nasuelli, D., DE MASI, R., MONTI BRAGADIN, L., Tommasi, M. A., ZAMBITO MARSALA, S., Moretti, Rita, Bratina, A., Ukmar, M., POZZI MUCELLI, R. S., Grop, A., Cazzato, G., Zorzon, Marino, Zivadinov, R., Sepcic, J., Nasuelli, D., DE MASI, R., MONTI BRAGADIN, L., Tommasi, M. A., ZAMBITO MARSALA, S., Moretti, Rita, Bratina, A., Ukmar, M., POZZI MUCELLI, R. S., Grop, A., Cazzato, G., and Zorzon, Marino
- Published
- 2001
4. Magnetic resonance imaging techniques as predictors of cognitive impairment in multiple sclerosis
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ZIVADINOV R, MONTI BRAGADIN L, NASUELLI D, DE MASI R, UKMAR M, POZZI MUCELLI R. S, ANTONELLO R, ZORZON, MARINO, Zivadinov, R, MONTI BRAGADIN, L, Nasuelli, D, DE MASI, R, Ukmar, M, POZZI MUCELLI R., S, Antonello, R, and Zorzon, Marino
- Published
- 2001
5. MRI TECHNIQUES AND COGNITIVE IMPAIRMENT IN EARLY PHASE OF RELAPSING-REMITTING MULTIPLE SCLEROSIS
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ZIVADINOV R., DE MASI R., NASUELLI D., MONTI BRAGADIN L., UKMAR M., POZZI MUCELLI R. S., GROP A., CAZZATO G., ZORZON, MARINO, Zivadinov, R., DE MASI, R., Nasuelli, D., MONTI BRAGADIN, L., Ukmar, M., POZZI MUCELLI, R. S., Grop, A., Cazzato, G., and Zorzon, Marino
- Published
- 2001
6. Value of different magnetic resonance imaging techniques in predicitng the patterns of cognitive impairment in early phase of relapsing-remitting multiple sclerosis
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Zivadinov, R, Ukmar, Maja, Moretti, Rita, Zorzon, M, Monti Bragadin, L, Zanier, F, Cazzato, G., AAVV, Zivadinov, R, Ukmar, Maja, Moretti, Rita, Zorzon, M, Monti Bragadin, L, Zanier, F, and Cazzato, G.
- Subjects
PP-MS ,cognition ,MRI ,RR-MS - Abstract
Value of different magnetic resonance imaging techniques in predicitng the patterns of cognitive impairment in early phase of relapsing-remitting multiple sclerosis
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- 2000
7. Sexual dysfunction in Multiple Sclerosis. A correlation analysis study
- Author
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Zivadinov R, Zorzon M, Bosco A, Monti Bragadin L, Iona L, Cazzato G., MORETTI, Rita, Zivadinov, R, Zorzon, M, Bosco, A, Monti Bragadin, L, Moretti, Rita, Iona, L, and Cazzato, G.
- Subjects
sexual disturbance ,ms ,sexual disturbances - Abstract
Sexual alteration in RR and PP SM
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- 1999
8. Long and short lasting side effects of high dose of methylprednisolone pulse therapy in multiple sclerosis. A study on 1527 courses
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Bosco A, Zivadinov R, Monti Bragadin L, Antonello RM, Torre P, Cazzato G, Zorzon M., MORETTI, Rita, Bosco, A, Moretti, Rita, Zivadinov, R, Monti Bragadin, L, Antonello, Rm, Torre, P, Cazzato, G, and Zorzon, M.
- Subjects
MP ,Steroids ,MS ,Steroid - Abstract
Long and short lasting side effects reported after high doses of methylprednisolone pulse therapy in MS patietns with and without poussee
- Published
- 1999
9. Olfactory loss in Multiple Sclerosis
- Author
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Zivadinov R, Zorzon M, Monti Bragadin L, De Masi R. Nasuelli D, Pagliaro G, Cazzato G., MORETTI, Rita, Zivadinov, R, Zorzon, M, Monti Bragadin, L, De Masi R., Nasuelli D, Moretti, Rita, Pagliaro, G, and Cazzato, G.
- Subjects
olfactive perception ,MS - Abstract
Olfactory altered perception analysed in MS
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- 1999
10. Magnetization transfer ratio delle lesioni captanti e non captanti gadolinio nella sclerosi multipla
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Bosco A, Stival B, Zivadinov R, Monti Bragadin L, Antonello RM, Cazzato G., UKMAR, MAJA, LONGO, RENATA, MORETTI, Rita, Bosco, A, Ukmar, Maja, Longo, Renata, Stival, B, Zivadinov, R, Moretti, Rita, Monti Bragadin, L, Antonello, Rm, and Cazzato, G.
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magnetization transfer ratio ,gadolinio ,SM - Abstract
MAgnetization transfer ratio nella diagnosi ed identificazione di lesioni captanti e non in SM
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- 1998
11. Magnetic resonance imaging techniques as predictors of cognitive impairment in multiple sclerosis
- Author
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Zivadinov, R, MONTI BRAGADIN, L, Nasuelli, D, DE MASI, R, Ukmar, M, POZZI MUCELLI, R. S., Antonello, R, and Zorzon, Marino
- Published
- 2001
12. A longitudinal study of brain atrophy and cognitive disturbances in early phase of relapsing remitting multiple sclerosis
- Author
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Živadinov, Robert, Zorzon, M., Sepčić, Juraj, Monti-Bragadin, L., Moretti, R., De Masi, R., Nasuelli, D., Zambito Marsala, S., Tommasi, M.A., Ukmar, M., Pozzi-Mucelli, R.S., Grop, A., Cazzato, G., and Clanet, M.
- Subjects
brain ,atrophy ,cognitive disturbances ,multiple sclerosis - Abstract
Introduction. Longitudinal studies apt to determine which are the most sensitive MRI parameters in monitoring cognitive decline in MS are lacking. Objective. The aim of the study was to establish if changes of brain parenchymal (BP) volume, and T2 and T1 lesion volumes can predict the cognitive impairment. Methods. For 2 years we monitored 53 patients with clinically definite RR MS. The neuropsychological performances, the psychological functioning and the neurologic disability have been assessed at baseline and after 2 years. Patient also underwet brain MRI, T2 and T1 lesion load volumes were measured by a semiautomatic technique. Quantification of BP volumes was obtained using a fully automatic highly reproducible computerized interactive program. The relationship between cognitive impairment and MRI abnormalities was investigated by partial correlation coefficients analysis excluding the effects of age, education, depressiom and anxiety. Results. The mean change in the two years of the study for T2, T1 and BP volumes were +1.7 mL (29.8%), 95% C.I. 1.3-2.2, p=0.005, +0.2 mL (25%), 95% C.I. 0.15-0.26, p=0.004 and -32.3 mL (27%), 95% C.I. 24.2-42.3 ; p= 1.0 point in the EDSS had a decrease in BP volume of 99 ml (8%), 95% C.I. 47.6-182.3 ; p=0.005. Conclusions. Our data suggest that in RR MS patients the cognitive deterioration over time may rely more on BP atrophy than on the extent of disease burden in the brain.
- Published
- 2000
13. Sexual dysfunction in multiple sderosis: a case-control study. 1. Frequency and comparison of groups
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Zorzon, M., Zivadinov, R., Bosco, A., Monti Bragadin, L., Moretti, Rita, Bonfigli, L., Morassi, P., Cazzato Clinical Neurology, L. G. Iona G., University of Trieste, Trieste, Italy, M., Zorzon, R., Zivadinov, A., Bosco, L., Monti Bragadin, Moretti, Rita, L., Bonfigli, P., Morassi, L. G. Iona G., Cazzato Clinical Neurology, University of, Trieste, and Trieste, Italy
- Subjects
medicine.medical_specialty ,Pediatrics ,050109 social psychology ,Human sexuality ,multiple sclerosis ,Social life ,Central nervous system disease ,03 medical and health sciences ,Epidemiology ,medicine ,0501 psychology and cognitive sciences ,In patient ,sexual disturbances ,030505 public health ,business.industry ,Multiple sclerosis ,05 social sciences ,Case-control study ,medicine.disease ,Surgery ,Sexual dysfunction ,Neurology ,multiple sclerosi ,Neurology (clinical) ,medicine.symptom ,0305 other medical science ,business - Abstract
Sexual dysfunction is a very important but often overlooked symptom of multiple sclerosis. To investigate the type and frequency of symptoms of sexual dysfunction in patient suffering from multiple sclerosis, we performed a case-control study comparing 108 unselected patient with definite multiple sclerosis, 97 patient with chronic disease and 1 10 healthy individuals with regard to sexual function, sphincteric function, physical disorders impeding sexual activity and the impact of sexual dysfunction on social life. Information has been collected from a face-to-face structured interview performed by a doctor of the same gender as the patient. The disability, the cognitive performances, the psychiatric conditions and the psychological profile of patien t a nd co ntrols have bee n assessed. Sexul a dysfu nction was prese nt in 73.1% of cases, in 39.2% of chronic disease co ntrols and in 12.7% of h e althy co ntrols (P < 0.000 1). Male cases reported symptoms of sexual dysfunction more freq ue ntly th an female cases (P
- Published
- 1999
14. Sexual dysfunction in multiple sclerosis: a case-control study. I. Frequency and comparison of groups.
- Author
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Zorzon, M., Zivadinov, R., Bosco, A., Monti Bragadin, L., Moretti, R., Bonfigli, L., Morassi, P., Iona, L.G., and Cazzato, G.
- Subjects
MULTIPLE sclerosis ,SEXUAL dysfunction ,SEX differences (Biology) - Abstract
Sexual dysfunction is a very important but often overlooked symptom of multiple sclerosis. To investigate the type and frequency of symptoms of sexual dysfunction in patients suffering from multiple sclerosis, we performed a case-control study comparing 108 unselected patients with definite multiple sclerosis, 97 patients with chronic disease and 110 healthy individuals with regard to sexual function, sphincteric function, physical disorders impeding sexual activity and the impact of sexual dysfunction on social life. Information has been collected from a face-to-face structured interview performed by a doctor of the same gender as the patient. The disability, the cognitive performances, the psychiatric conditions and the psychological profile of patients and controls have been assessed. Sexual dysfunction was present in 73.1% of cases, in 39.2% of chronic disease controls and in 12.7% of healthy controls (P<0.0001). Male cases reported symptoms of sexual dysfunction more frequently than female cases (P<0.002). Symptoms of sexual dysfunction more commonly reported in patients with multiple sclerosis were anorgasmia or hyporgasmia (37.1%), decreased vaginal lubrication (35.7%) and reduced libido (31.4%) in women, and impotence or erectile dysfunction (63.2%), ejaculatory dysfunction and/or orgasmic dysfunction (50%) and reduced libido (39.5%) in men. Seventy-five per cent of cases, 51.5% of chronic disease controls and 28.2% of healthy controls (P<0.0001) experienced symptoms of sphincteric dysfunction. In conclusion, a substantial part of our sample of patients with multiple sclerosis reported symptoms of sexual and sphincteric dysfunction. Both sexual and sphincteric dysfunction were significantly more common in patients with multiple sclerosis than in either control group. Our findings suggest that a peculiar damage of the structures involved in sexual function is responsible for the dysfunction in patients with multiple sclerosis, but the highly significant lower frequency of symptoms of depression and anxiety in healthy controls may also imply a possible causative role of psychological factors. [ABSTRACT FROM AUTHOR]
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- 1999
- Full Text
- View/download PDF
15. Sexual dysfunction in multiple sclerosis: II. Correlation analysis.
- Author
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Zivadinov, R., Zorzon, M., Bosco, A., Monti Bragadin, L., Moretti, R., Bonfigli, L., Iona, L.G., and Cazzato, G.
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SEXUAL dysfunction ,MULTIPLE sclerosis ,PATIENTS - Abstract
Sexual dysfunction affects a large part of patients suffering from multiple sclerosis, but some aspects of its clinical presentation and aetiology are not clearly defined yet. In an unselected sample of 108 patients with definite multiple sclerosis we investigated the relationship between symptoms of sexual dysfunctioning and sphincteric dysfunction, patients' and disease characteristics, disability and neurological impairment, psychological and cognitive functioning. Sexual dysfunction directly correlated with presence of physical disorders (r=0.37, P=0.0004), low educational level (r=0.32, P<0.002), disability (r=0.31, P<0.003), age at onset of symptoms (r=0.30, P<0.003), sphincteric dysfunction (r=0.30, P<0.003), age (r=0.30, P<0.004), depression (r=0.29, P<0.005), fatigue (r=0.29, P=0.005), cognitive deterioration (r=0.26, P<0.01), primary-progressive course of disease (r=0.25, P<0.02), neurological impairment (r=0.25, P<0.02), marriage (r=0.24, P<0.02), anxiety (r=0.23, P<0.03), male gender (r=0.22, P=0.03) bladder dysfunction (r=0.29, P<0.04), and unemployment (r=0.21, P<0.04). Sexual dysfunction correlated inversely with relapsing – remitting course of disease (r=-0.31, P<0.002). No correlation was found between sexual dysfunction and bowel dysfunction, duration of disease, secondary-progressive course of disease, number and frequency of sexual intercourses in the last year, number of partners, number of exacerbations in the last year, number of months since last exacerbation, masturbation, and fertility. In conclusion, the association between sexual dysfunction and sphincteric dysfunction indicates a common aetiology corresponding to the frequent involvement of the spinal cord in multiple sclerosis, but the concomitant correlation between sexual dysfunction and other variables suggests the possible aetiological role of physical, psychological and sociological factors as well. [ABSTRACT FROM AUTHOR]
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- 1999
- Full Text
- View/download PDF
16. Olfactory dysfunction and extent of white matter abnormalities in multiple sclerosis: a clinical and MR study
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Francesca Zanier, Marino Zorzon, Robert Zivadinov, Giuseppe Cazzato, Rodolfo M. Antonello, L. M. Bragadin, Maja Ukmar, Zorzon, Marino, Ukmar, M., MONTI BRAGADIN, L., Zanier, F., Antonello, R. A., Cazzato, G., and Zivadinov, R.
- Subjects
Adult ,Male ,Olfactory system ,Pathology ,medicine.medical_specialty ,Multiple Sclerosis ,Olfaction ,Statistics, Nonparametric ,050105 experimental psychology ,Temporal lobe ,Central nervous system disease ,White matter ,Disability Evaluation ,Olfaction Disorders ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,0501 psychology and cognitive sciences ,Neurologic Examination ,Analysis of Variance ,medicine.diagnostic_test ,Echo-Planar Imaging ,Multiple sclerosis ,05 social sciences ,Confounding Factors, Epidemiologic ,Magnetic resonance imaging ,030229 sport sciences ,Middle Aged ,medicine.disease ,Smell ,medicine.anatomical_structure ,Neurology ,Frontal lobe ,Regression Analysis ,Female ,Neurology (clinical) ,Psychology - Abstract
Background: The relative contribution to the olfactory dysfunction of the lesions in the specific brain regions involved in olfaction compared with the lesions scattered all over the rest of the brain has not been fully clarified yet in patients with multiple sclerosis (MS). The concurrent use of Magnetic Resonance Imaging (MRI) and a standardized test of odor identification ability now permits to study the relation between smell loss and the extent of white matter abnormalities. Methods: We tested the olfactory function of 40 patients with definite MS and of 40 age-sex- and smoking-habit-matched healthy controls by using the Cross Cultural Smell Identification Test. We measured also the lesion load on T2-weighted images in the inferior-frontal and temporal lobes and in the rest of the brain in MS patients. Therefore, we tried to correlate measures of lesion load and smell test scores. Results: A robust correlation was demonstrated between MR measures of lesion load in the white matter of the olfactory brain region and smell loss (r=70.739, P50.0001). A significant relationship has been found even after taking potential confounding factors, such as sex, age, disease duration, disability, anxiety and depression, into account (r=70.90, P50.0001). Conclusions: Our findings show, in MS patients with stable neurological impairment and no recent disease exacerbation, a correlation between smell loss and the lesion load in the regions of the brain involved in olfaction and support the theory that the extent and severity of MRI abnormalities in specific brain regions are related to the presence of selective neurologic and neuropsychologic impairment.
- Published
- 2000
17. Positivity of cytomegalovirus antibodies predicts a better clinical and radiological outcome in multiple sclerosis patients
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Alessio Bratina, Roberto Pozzi-Mucelli, Istvan Pirko, Maja Ukmar, Giuseppe Cazzato, Massimo Zambon, Attilio Grop, D. Nasuelli, Luisa Monti-Bragadin, Rodolfo M. Antonello, Maria Antonietta Tommasi, Maurizia Serafin, Marino Zorzon, Robert Zivadinov, Aaron J. Johnson, Christina Furlan, Zivadinov, R, Nasuelli, D, TOMMASI M., A, Serafin, M, Bratina, Alessio, Ukmar, M, Pinko, I, JOHNSON A., J, Furlan, C, POZZI MUCELLI R., S, MONTI BRAGADIN, L, Grop, A, Zambon, M, ANTONELLO R., M, Cazzato, G, and Zorzon, Marino
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,viruses ,CYTOMEGALOVIRUS ,Congenital cytomegalovirus infection ,IMMUNE EVASION ,Antibodies, Viral ,medicine.disease_cause ,Gastroenterology ,Rubella ,Virus ,Diagnosis, Differential ,Random Allocation ,Internal medicine ,medicine ,MRI ,DISEASE SEVERITY ,IMMUNOMODULATION ,MULTIPLE SCLEROSIS ,Cluster Analysis ,Humans ,Aged ,Neurologic Examination ,Expanded Disability Status Scale ,business.industry ,Multiple sclerosis ,Varicella zoster virus ,General Medicine ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Titer ,Herpes simplex virus ,Neurology ,Case-Control Studies ,Immunoglobulin G ,Immunology ,Regression Analysis ,Female ,Neurology (clinical) ,business ,Follow-Up Studies - Abstract
To establish the relationship between the presence and titer of virus-specific serum- and cerebrospinal fluid (CSF)-antibodies in multiple sclerosis (MS) patients and disease severity measured with different quantitative magnetic resonance imaging (MRI) techniques.We investigated an association between clinical and MRI measures of disease activity and the presence and titer of IgG antibodies against seven common viruses (measles, rubella, herpes simplex virus type 1 and 2, varicella zoster virus, cytomegalovirus (CMV) and Epstein-Barr virus). One hundred and forty (90 female/50 male) patients with definite MS and 131 age and sex-matched controls participated in the study. Antibody positivity and titer were ascertained by the enzyme linked immunosorbent assay (ELISA) technique and clinical assessment was performed by evaluating the expanded disability status scale (EDSS) score and the lifetime relapse rate (LRR). T1- and T2-lesion loads (LL) and the brain parenchymal fraction (BPF) were calculated.Multiple analyses showed that there was an association between antibody positivity against CMV and higher titer and better clinical and MRI outcomes. The cluster analyses indicated that patients positive for antibodies against CMV had significantly older age at onset (uncorr p = 0.001 and corr p = 0.009), lower LRR (uncorr p = 0.003 and corr p = 0.03) and higher BPF (uncorr p = 0.004 and pcorr p = 0.04). CMV-positive patients who had higher antibody titer showed lower T2-LL (uncorr p = 0.003 and corr p = 0.03) and higher BPF (uncorr p = 0.006 and corr p = 0.05).Surprisingly, our results focused attention on the 'protective' role of a particular virus. CMV is probably capable of triggering some immunomodulating/immune evasion mechanisms which may decrease immune reactivity in MS patients. Further studies are needed to confirm and elucidate our study results on a larger sample of MS patients and in animal model studies.
- Published
- 2006
18. Sexual dysfunction in multiple sclerosis: a 2-year follow-up study
- Author
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D. Nasuelli, Giuseppe Cazzato, Marino Zorzon, Robert Zivadinov, Rita Moretti, L Monti Bragadin, R. De Masi, Zorzon, Marino, Zivadinov, R., MONTI BRAGADIN, L., Moretti, Rita, DE MASI, R., Nasuelli, D., and Cazzato, G.
- Subjects
Adult ,Male ,medicine.medical_specialty ,Longitudinal study ,Multiple Sclerosis ,Multivariate analysis ,Exacerbation ,Sex Factors ,Surveys and Questionnaires ,Internal medicine ,Prevalence ,medicine ,Humans ,Urinary Bladder, Neurogenic ,Fatigue ,Physician-Patient Relations ,Univariate analysis ,Muscle Weakness ,Multiple sclerosis ,Confounding ,behave ,ms ,medicine.disease ,Surgery ,Sexual Dysfunction, Physiological ,Sexual dysfunction ,Neurology ,Female ,Neurology (clinical) ,medicine.symptom ,Sexual function ,Psychology ,Follow-Up Studies - Abstract
Background and objective. Sexual dysfunction severely affects the quality of life of patients, but longitudinal studies of sexual function in multiple sclerosis are lacking. We performed a study on a group of patients with multiple sclerosis to evaluate the change in sexual function and to examine the relationship between sexual dysfunction and other clinical variables over time. Methods. A 2-year follow-up study on 99 patients with definite multiple sclerosis. Information on sexual and sphincteric disturbances have been collected through face-to-face structured interviews. Disability, independence, cognitive performances and psychological functioning have also been assessed. Spearman rank correlation analysis corrected for multiple comparisons, and linear regression analysis have been performed to test variables relationship and remove the effect of potential confounding covariates. Results. The proportion of patients with sexual dysfunction remained over 70% and did not change during the 2-year follow-up, but the extent and number of symptoms increased significantly The number of symptoms of sexual dysfunction did not change significantly after an exacerbation. Significantly, more patients than before the study resorted to counseling and discussed with doctors of sexual matters. In the univariate analysis, changes in sexual function over time correlated with changes in bladder function (r=0.47, p
- Published
- 2001
19. Olfactory loss in multiple sclerosis
- Author
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Marino Zorzon, Robert Zivadinov, Giuseppe Cazzato, L Monti Bragadin, G Pagliaro, Zivadinov, R., Zorzon, Marino, MONTI BRAGADIN, L., Pagliaro, G., and Cazzato, G.
- Subjects
Adult ,Male ,medicine.medical_specialty ,Multiple Sclerosis ,Olfaction ,Neurological disorder ,Neuropsychological Tests ,Severity of Illness Index ,Central nervous system disease ,Sex Factors ,Internal medicine ,Sickness Impact Profile ,Severity of illness ,medicine ,Humans ,Psychiatry ,Contraception Behavior ,Depression (differential diagnoses) ,Multiple sclerosis ,Smoking ,Middle Aged ,medicine.disease ,Perfume ,Smell ,Mood ,Neurology ,Agnosia ,Anxiety ,Female ,Neurology (clinical) ,medicine.symptom ,Psychology - Abstract
The objectives of the present study were to test odor identification ability in patients with multiple sclerosis (MS) and to examine possible correlations between smell identification test scores and various clinical variables. We performed a case-control study comparing the Cross Cultural Smell Identification Test scores of 40 patients with definite multiple sclerosis with those obtained in 40 age-, sex- and smoking-habit-matched healthy controls. The neurological impairment, the disability, the cognitive performances and the psychological functioning were also assessed. Patients with multiple sclerosis scored significantly poorer than controls on the Cross-Cultural Smell Identification Test (P
- Published
- 1999
20. Gabapentin as a drug therapy of intractable hiccup
- Author
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Antonello, R. M., rita moretti, Zivadinov, R., Torre, P., Bragadin, L. M., Bosco, A., Cazzato, G., Antonello, Rm, Moretti, Rita, Zivadinov, R, Torre, P, Monti Bragadin, L, Bosco, A, and Cazzato, G.
- Subjects
myoclonu ,hiccup ,gabapentin ,myoclonus - Abstract
Myoclonus as causative factor of intractable hiccup: gabapentin and its mechanism to stop myoclonus
- Published
- 1998
21. Positivity of cytomegalovirus antibodies predicts a better clinical and radiological outcome in multiple sclerosis patients.
- Author
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Zivadinov R, Nasuelli D, Tommasi MA, Serafin M, Bratina A, Ukmar M, Pirko I, Johnson AJ, Furlan C, Pozzi-Mucelli RS, Monti-Bragadin L, Grop A, Zambon M, Antonello RM, Cazzato G, and Zorzon M
- Subjects
- Adolescent, Adult, Aged, Case-Control Studies, Cluster Analysis, Diagnosis, Differential, Female, Follow-Up Studies, Humans, Immunoglobulin G metabolism, Magnetic Resonance Imaging methods, Male, Middle Aged, Neurologic Examination, Random Allocation, Regression Analysis, Antibodies, Viral, Cytomegalovirus immunology, Multiple Sclerosis diagnosis, Multiple Sclerosis virology
- Abstract
Objectives: To establish the relationship between the presence and titer of virus-specific serum- and cerebrospinal fluid (CSF)-antibodies in multiple sclerosis (MS) patients and disease severity measured with different quantitative magnetic resonance imaging (MRI) techniques., Methods: We investigated an association between clinical and MRI measures of disease activity and the presence and titer of IgG antibodies against seven common viruses (measles, rubella, herpes simplex virus type 1 and 2, varicella zoster virus, cytomegalovirus (CMV) and Epstein-Barr virus). One hundred and forty (90 female/50 male) patients with definite MS and 131 age and sex-matched controls participated in the study. Antibody positivity and titer were ascertained by the enzyme linked immunosorbent assay (ELISA) technique and clinical assessment was performed by evaluating the expanded disability status scale (EDSS) score and the lifetime relapse rate (LRR). T1- and T2-lesion loads (LL) and the brain parenchymal fraction (BPF) were calculated., Results: Multiple analyses showed that there was an association between antibody positivity against CMV and higher titer and better clinical and MRI outcomes. The cluster analyses indicated that patients positive for antibodies against CMV had significantly older age at onset (uncorr p = 0.001 and corr p = 0.009), lower LRR (uncorr p = 0.003 and corr p = 0.03) and higher BPF (uncorr p = 0.004 and pcorr p = 0.04). CMV-positive patients who had higher antibody titer showed lower T2-LL (uncorr p = 0.003 and corr p = 0.03) and higher BPF (uncorr p = 0.006 and corr p = 0.05)., Discussion: Surprisingly, our results focused attention on the 'protective' role of a particular virus. CMV is probably capable of triggering some immunomodulating/immune evasion mechanisms which may decrease immune reactivity in MS patients. Further studies are needed to confirm and elucidate our study results on a larger sample of MS patients and in animal model studies.
- Published
- 2006
- Full Text
- View/download PDF
22. A longitudinal study of quality of life and side effects in patients with multiple sclerosis treated with interferon beta-1a.
- Author
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Zivadinov R, Zorzon M, Tommasi MA, Nasuelli D, Bernardi M, Monti-Bragadin L, and Cazzato G
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- Activities of Daily Living, Adolescent, Adult, Analysis of Variance, Anxiety chemically induced, Cognition drug effects, Cognition physiology, Depression chemically induced, Disability Evaluation, Disease Progression, Fatigue chemically induced, Female, Humans, Interferon beta-1a, Linear Models, Longitudinal Studies, Male, Middle Aged, Surveys and Questionnaires, Interferon-beta adverse effects, Multiple Sclerosis drug therapy, Multiple Sclerosis psychology, Quality of Life psychology
- Abstract
In a 12-month follow-up study, we evaluated 27 patients (18 F and 9 M) with relapsing-remitting (RR) multiple sclerosis (MS), who had started treatment with interferon beta-1a (IFNbeta-1a) (Avonex), 30 microg i.m. once weekly, 6-18 months (median 10 months) before study entry. Quality of life (QOL), disability, independence, cognitive performances, symptoms of depression and anxiety, and fatigue were assessed at baseline, 6 months and 12 months. The frequency and severity of the side effects of treatment, at hours 0-12, 13-48 and 49-168 after the injection, were self-reported weekly in a structured questionnaire. QOL did not change significantly during the follow-up. The percentage of patients who reported side effects after the injection of IFNbeta-1a remained constant during the 52 weeks. The mean number of side effects increased significantly from the 6th to the 12th month. The general linear model analysis of variance disclosed significant changes over time for almost all side effects, but we did not find any correlation between QOL and number of side effects. In conclusion, 1-year treatment with IFNbeta-1a did not significantly change patient's QOL. Disability progression correlated with patient's QOL. Side effects, which were mild, did not diminish over time, did not induce treatment discontinuation and did not interfere with QOL.
- Published
- 2003
- Full Text
- View/download PDF
23. The use of standardized incidence and prevalence rates in epidemiological studies on multiple sclerosis. A meta-analysis study.
- Author
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Zivadinov R, Iona L, Monti-Bragadin L, Bosco A, Jurjevic A, Taus C, Cazzato G, and Zorzon M
- Subjects
- Adolescent, Adult, Age Distribution, Aged, Child, Child, Preschool, Female, Humans, Incidence, Infant, Male, Middle Aged, Prevalence, Reproducibility of Results, Sex Distribution, Epidemiologic Studies, Multiple Sclerosis epidemiology
- Abstract
Objective: To demonstrate whether or not the age and sex adjustment of incidence and prevalence rates in multiple sclerosis (MS) could allow more reliable comparison between epidemiological studies performed in different areas of the world and to establish if the latitude gradient theory could be confirmed after the standardization for age and sex distribution., Methods: A meta-analysis of population-based incidence and prevalence studies on MS from 1980 through 1998 using the terms 'multiple sclerosis', 'prevalence' and 'incidence' in the bibliographic databases MEDLINE and EMBASE was performed. We included studies that reported the diagnostic criteria, number of cases and the population studied, the date of the study, the latitude, and the age- and sex-specific crude incidence and prevalence rates. According to the inclusion criteria, 69 of 127 papers on prevalence and 22 of 70 papers on incidence were considered for age adjustment and 27 prevalence and 8 incidence studies for sex adjustment. The mean incidence and prevalencerates and the 95% confidence intervals age- and sex-adjusted to the World and the European standard populations were calculated., Results: The Spearman rank correlation and the multiple regression analyses indicated that age adjustment to standard populations could overcome the limitations in comparing the crude prevalence and incidence rates of different epidemiological studies on MS. When the mean crude and age- and sex-adjusted prevalence and age-adjusted incidence rates were stratified by latitude (from south to north), the latitudinal gradient, which was highly significant for the crude rates, became less remarkable for the age- and sex-adjusted prevalence rates and not significant for the age-adjusted incidence rates., Conclusions: The crude incidence and prevalence rates in epidemiological studies on MS should be age- and sex-adjusted to a common standard population to permit a more reliable comparison among studies performed in different countries. Our findings support the opinion that the latitude does not play a key role in determining the onset of MS. Whenever possible, the crude incidence and prevalence rates should be adjusted to the ethnic origin and migration characteristics., (Copyright 2003 S. Karger AG, Basel)
- Published
- 2003
- Full Text
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24. Sexual dysfunction in multiple sclerosis: a 2-year follow-up study.
- Author
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Zorzon M, Zivadinov R, Monti Bragadin L, Moretti R, De Masi R, Nasuelli D, and Cazzato G
- Subjects
- Adult, Fatigue etiology, Fatigue physiopathology, Female, Follow-Up Studies, Humans, Male, Muscle Weakness etiology, Muscle Weakness physiopathology, Physician-Patient Relations, Prevalence, Sex Factors, Surveys and Questionnaires, Urinary Bladder, Neurogenic etiology, Urinary Bladder, Neurogenic physiopathology, Multiple Sclerosis complications, Multiple Sclerosis physiopathology, Sexual Dysfunction, Physiological etiology, Sexual Dysfunction, Physiological physiopathology
- Abstract
Background and Objective: Sexual dysfunction severely affects the quality of life of patients, but longitudinal studies of sexual function in multiple sclerosis are lacking. We performed a study on a group of patients with multiple sclerosis to evaluate the change in sexual function and to examine the relationship between sexual dysfunction and other clinical variables over time., Methods: A 2-year follow-up study on 99 patients with definite multiple sclerosis. Information on sexual and sphincteric disturbances have been collected through face-to-face structured interviews. Disability, independence, cognitive performances and psychological functioning have also been assessed. Spearman rank correlation analysis corrected for multiple comparisons, and linear regression analysis have been performed to test variables relationship and remove the effect of potential confounding covariates., Results: The proportion of patients with sexual dysfunction remained over 70% and did not change during the 2-year follow-up, but the extent and number of symptoms increased significantly The number of symptoms of sexual dysfunction did not change significantly after an exacerbation. Significantly, more patients than before the study resorted to counseling and discussed with doctors of sexual matters. In the univariate analysis, changes in sexual function over time correlated with changes in bladder function (r=0.47, p<0.0001) and EDSS score (r=0.41, p<0.0001), but the multivariate analysis demonstrated that only bladder dysfunction was independently related to sexual dysfunction (R=0.36, p=0.003) when the effect of psychological factors were removed., Conclusions: Symptoms of sexual dysfunction increase in significance and number over time in patients with multiple sclerosis. Relapses did not influence the number of symptoms of sexual dysfunction, but a worsening of pre-existing symptoms cannot be excluded. The change of sexual function appears to be independently associated to bladder dysfunction.
- Published
- 2001
- Full Text
- View/download PDF
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