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2 results on '"MONOCYTE ARREST"'

1. Rapid Internalization and Nuclear Translocation of CCL5 and CXCL4 in Endothelial Cells

Author

Johan W. M. Heemskerk, Annemiek Dickhout, Rory R. Koenen, Sanne L. N. Brouns, Alexandra C.A. Heinzmann, Dawid M. Kaczor, Marc A. M. J. van Zandvoort, Biochemie, RS: Carim - B01 Blood proteins & engineering, RS: Carim - B03 Cell biochemistry of thrombosis and haemostasis, Moleculaire Celbiologie, and RS: GROW - R2 - Basic and Translational Cancer Biology

Subjects
0301 basic medicine, Chemokine, OLIGOMERIZATION, DUFFY ANTIGEN, 030204 cardiovascular system & hematology, 0302 clinical medicine, BINDING, Biology (General), DEPOSITION, Internalization, Chemokine CCL5, PLATELET CHEMOKINES, Spectroscopy, media_common, biology, Chemistry, General Medicine, 3. Good health, Computer Science Applications, Cell biology, Endothelial stem cell, medicine.anatomical_structure, monocyte, endothelial cell, EXPRESSION, QH301-705.5, MIGRATION, media_common.quotation_subject, Active Transport, Cell Nucleus, Endocytosis, Clathrin, Catalysis, CCL5, Article, Cell Line, Inorganic Chemistry, 03 medical and health sciences, RANTES, medicine, Humans, Physical and Theoretical Chemistry, Molecular Biology, QD1-999, Dynamin, GLYCOSAMINOGLYCANS, Cell Nucleus, Monocyte, Organic Chemistry, chemokine, Endothelial Cells, platelet factor 4, MONOCYTE ARREST, 030104 developmental biology, ATHEROSCLEROSIS, biology.protein
Abstract

International journal of molecular sciences 22(14), 7332 (2021). doi:10.3390/ijms22147332 special issue: "Special Issue "Molecular Research in Cardiovascular Disease" / Special Issue Editors: Prof. Dr. Maria I. Dorobantu, Prof. Dr. Maya Simionescu", Published by Molecular Diversity Preservation International, Basel

Published
2021
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2. Suppression of zinc finger protein 580 by high oxLDL/LDL-ratios is followed by enhanced expression of endothelial IL-8

Author

Hoffmann, Christian J., Hohberg, Margret, Chlench, Sven, Maroski, Julian, Drab, Marek, Siegel, Günter, Pries, Axel R., and Zakrzewicz, Andreas

Subjects
*ZINC-finger proteins, *LOW density lipoproteins, *GENE expression, *ENDOTHELIUM, *MONOCYTES, *INTERLEUKIN-8, *IMMUNOBLOTTING, *REVERSE transcriptase polymerase chain reaction
Abstract

Abstract: Objective: The Interleukin 8 (IL-8) response of endothelial cells to lipoproteins has well known implications for the development and progression of atherosclerosis. In this study we sought for the role of zinc finger protein 580 (ZNF580) in the endothelial IL-8 response to lipoproteins. Methods: In human umbilical vein endothelial cells (HUVEC) ZNF580 and IL-8 levels were examined by real-time-RT-PCR, immunoblotting and immunostaining or ELISA, respectively. Results: ZNF580 is located in the nucleus and regulated by LDL and HDL depending on the oxLDL/LDL-ratio but not by TNFα. IL-8 expression profiles are inversely influenced by the oxLDL/LDL-ratio, both in vitro and in vivo. Knock down of ZNF580 enhances the expression and release of IL-8 and increases monocyte arrest under flow conditions in vitro. Conclusions: ZNF580 is a novel factor in the lipoprotein-dependent regulation of IL-8 and monocyte arrest. Therefore it may be a new potential target for intervention in atherosclerosis. [Copyright &y& Elsevier]

Published
2011
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