2,616 results on '"MILNER, A. D."'
Search Results
2. Characterizing Long COVID in Children and Adolescents
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Gross, Rachel S, Thaweethai, Tanayott, Kleinman, Lawrence C, Snowden, Jessica N, Rosenzweig, Erika B, Milner, Joshua D, Tantisira, Kelan G, Rhee, Kyung E, Jernigan, Terry L, Kinser, Patricia A, Salisbury, Amy L, Warburton, David, Mohandas, Sindhu, Wood, John C, Newburger, Jane W, Truong, Dongngan T, Flaherman, Valerie J, Metz, Torri D, Karlson, Elizabeth W, Chibnik, Lori B, Pant, Deepti B, Krishnamoorthy, Aparna, Gallagher, Richard, Lamendola-Essel, Michelle F, Hasson, Denise C, Katz, Stuart D, Yin, Shonna, Dreyer, Benard P, Carmilani, Megan, Coombs, K, Fitzgerald, Megan L, Güthe, Nick, Hornig, Mady, Letts, Rebecca J, Peddie, Aimee K, Taylor, Brittany D, Foulkes, Andrea S, Stockwell, Melissa S, Balaraman, Venkataraman, Bogie, Amanda, Bukulmez, Hulya, Dozor, Allen J, Eckrich, Daniel, Elliott, Amy J, Evans, Danielle N, Farkas, Jonathan S, Faustino, E Vincent S, Fischer, Laura, Gaur, Sunanda, Harahsheh, Ashraf S, Hasan, Uzma N, Hsia, Daniel S, Huerta-Montanez, Gredia, Hummel, Kathy D, Kadish, Matt P, Kaelber, David C, Krishnan, Sankaran, Kosut, Jessica S, Larrabee, Jerry, Lim, Peter Paul C, Michelow, Ian C, Oliveira, Carlos R, Raissy, Hengameh, Rosario-Pabon, Zaira, Ross, Judith L, Sato, Alice I, Stevenson, Michelle D, Talavera-Barber, Maria M, Teufel, Ronald J, Weakley, Kathryn E, Zimmerman, Emily, Bind, Marie-Abele C, Chan, James, Guan, Zoe, Morse, Richard E, Reeder, Harrison T, Akshoomoff, Natascha, Aschner, Judy L, Bhattacharjee, Rakesh, Cottrell, Lesley A, Cowan, Kelly, D'Sa, Viren A, Fiks, Alexander G, Gennaro, Maria L, Irby, Katherine, Khare, Manaswitha, Landeo Guttierrez, Jeremy, McCulloh, Russell J, Narang, Shalu, Ness- Cochinwala, Manette, Nolan, Sheila, Palumbo, Paul, Ryu, Julie, Salazar, Juan C, Selvarangan, Rangaraj, Stein, Cheryl R, Werzberger, Alan, Zempsky, William T, Aupperle, Robin, and Baker, Fiona C
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Biomedical and Clinical Sciences ,Clinical Sciences ,Health Sciences ,Emerging Infectious Diseases ,Neurosciences ,Coronaviruses ,Infectious Diseases ,Pediatric ,Minority Health ,Pain Research ,Infection ,Good Health and Well Being ,RECOVER-Pediatrics Consortium ,RECOVER-Pediatrics Group Authors ,Medical and Health Sciences ,General & Internal Medicine ,Biomedical and clinical sciences ,Health sciences - Abstract
ImportanceMost research to understand postacute sequelae of SARS-CoV-2 infection (PASC), or long COVID, has focused on adults, with less known about this complex condition in children. Research is needed to characterize pediatric PASC to enable studies of underlying mechanisms that will guide future treatment.ObjectiveTo identify the most common prolonged symptoms experienced by children (aged 6 to 17 years) after SARS-CoV-2 infection, how these symptoms differ by age (school-age [6-11 years] vs adolescents [12-17 years]), how they cluster into distinct phenotypes, and what symptoms in combination could be used as an empirically derived index to assist researchers to study the likely presence of PASC.Design, setting, and participantsMulticenter longitudinal observational cohort study with participants recruited from more than 60 US health care and community settings between March 2022 and December 2023, including school-age children and adolescents with and without SARS-CoV-2 infection history.ExposureSARS-CoV-2 infection.Main outcomes and measuresPASC and 89 prolonged symptoms across 9 symptom domains.ResultsA total of 898 school-age children (751 with previous SARS-CoV-2 infection [referred to as infected] and 147 without [referred to as uninfected]; mean age, 8.6 years; 49% female; 11% were Black or African American, 34% were Hispanic, Latino, or Spanish, and 60% were White) and 4469 adolescents (3109 infected and 1360 uninfected; mean age, 14.8 years; 48% female; 13% were Black or African American, 21% were Hispanic, Latino, or Spanish, and 73% were White) were included. Median time between first infection and symptom survey was 506 days for school-age children and 556 days for adolescents. In models adjusted for sex and race and ethnicity, 14 symptoms in both school-age children and adolescents were more common in those with SARS-CoV-2 infection history compared with those without infection history, with 4 additional symptoms in school-age children only and 3 in adolescents only. These symptoms affected almost every organ system. Combinations of symptoms most associated with infection history were identified to form a PASC research index for each age group; these indices correlated with poorer overall health and quality of life. The index emphasizes neurocognitive, pain, and gastrointestinal symptoms in school-age children but change or loss in smell or taste, pain, and fatigue/malaise-related symptoms in adolescents. Clustering analyses identified 4 PASC symptom phenotypes in school-age children and 3 in adolescents.Conclusions and relevanceThis study developed research indices for characterizing PASC in children and adolescents. Symptom patterns were similar but distinguishable between the 2 groups, highlighting the importance of characterizing PASC separately for these age ranges.
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- 2024
3. Deep phenotyping of post-infectious myalgic encephalomyelitis/chronic fatigue syndrome
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Walitt, Brian, Singh, Komudi, LaMunion, Samuel R., Hallett, Mark, Jacobson, Steve, Chen, Kong, Enose-Akahata, Yoshimi, Apps, Richard, Barb, Jennifer J., Bedard, Patrick, Brychta, Robert J., Buckley, Ashura Williams, Burbelo, Peter D., Calco, Brice, Cathay, Brianna, Chen, Li, Chigurupati, Snigdha, Chen, Jinguo, Cheung, Foo, Chin, Lisa M. K., Coleman, Benjamin W., Courville, Amber B., Deming, Madeleine S., Drinkard, Bart, Feng, Li Rebekah, Ferrucci, Luigi, Gabel, Scott A., Gavin, Angelique, Goldstein, David S., Hassanzadeh, Shahin, Horan, Sean C., Horovitz, Silvina G., Johnson, Kory R., Govan, Anita Jones, Knutson, Kristine M., Kreskow, Joy D., Levin, Mark, Lyons, Jonathan J., Madian, Nicholas, Malik, Nasir, Mammen, Andrew L., McCulloch, John A., McGurrin, Patrick M., Milner, Joshua D., Moaddel, Ruin, Mueller, Geoffrey A., Mukherjee, Amrita, Muñoz-Braceras, Sandra, Norato, Gina, Pak, Katherine, Pinal-Fernandez, Iago, Popa, Traian, Reoma, Lauren B., Sack, Michael N., Safavi, Farinaz, Saligan, Leorey N., Sellers, Brian A., Sinclair, Stephen, Smith, Bryan, Snow, Joseph, Solin, Stacey, Stussman, Barbara J., Trinchieri, Giorgio, Turner, Sara A., Vetter, C. Stephenie, Vial, Felipe, Vizioli, Carlotta, Williams, Ashley, Yang, Shanna B., and Nath, Avindra
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- 2024
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4. Variant STAT4 and Response to Ruxolitinib in an Autoinflammatory Syndrome
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Baghdassarian, Hratch, Blackstone, Sarah A, Clay, Owen S, Philips, Rachael, Matthiasardottir, Brynja, Nehrebecky, Michele, Hua, Vivian K, McVicar, Rachael, Liu, Yang, Tucker, Suzanne M, Randazzo, Davide, Deuitch, Natalie, Rosenzweig, Sofia, Mark, Adam, Sasik, Roman, Fisch, Kathleen M, Pimpale Chavan, Pallavi, Eren, Elif, Watts, Norman R, Ma, Chi A, Gadina, Massimo, Schwartz, Daniella M, Sanyal, Anwesha, Werner, Giffin, Murdock, David R, Horita, Nobuyuki, Chowdhury, Shimul, Dimmock, David, Jepsen, Kristen, Remmers, Elaine F, Goldbach-Mansky, Raphaela, Gahl, William A, O'Shea, John J, Milner, Joshua D, Lewis, Nathan E, Chang, Johanna, Kastner, Daniel L, Torok, Kathryn, Oda, Hirotsugu, Putnam, Christopher D, and Broderick, Lori
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Biomedical and Clinical Sciences ,Clinical Sciences ,Genetics ,Human Genome ,2.1 Biological and endogenous factors ,Inflammatory and immune system ,Janus Kinases ,Nitriles ,Pyrazoles ,Pyrimidines ,Scleroderma ,Systemic ,Autoimmune Diseases ,Mutation ,Missense ,Gain of Function Mutation ,Dermatologic Agents ,Anti-Inflammatory Agents ,Medical and Health Sciences ,General & Internal Medicine ,Biomedical and clinical sciences ,Health sciences - Abstract
BackgroundDisabling pansclerotic morphea (DPM) is a rare systemic inflammatory disorder, characterized by poor wound healing, fibrosis, cytopenias, hypogammaglobulinemia, and squamous-cell carcinoma. The cause is unknown, and mortality is high.MethodsWe evaluated four patients from three unrelated families with an autosomal dominant pattern of inheritance of DPM. Genomic sequencing independently identified three heterozygous variants in a specific region of the gene that encodes signal transducer and activator of transcription 4 (STAT4). Primary skin fibroblast and cell-line assays were used to define the functional nature of the genetic defect. We also assayed gene expression using single-cell RNA sequencing of peripheral-blood mononuclear cells to identify inflammatory pathways that may be affected in DPM and that may respond to therapy.ResultsGenome sequencing revealed three novel heterozygous missense gain-of-function variants in STAT4. In vitro, primary skin fibroblasts showed enhanced interleukin-6 secretion, with impaired wound healing, contraction of the collagen matrix, and matrix secretion. Inhibition of Janus kinase (JAK)-STAT signaling with ruxolitinib led to improvement in the hyperinflammatory fibroblast phenotype in vitro and resolution of inflammatory markers and clinical symptoms in treated patients, without adverse effects. Single-cell RNA sequencing revealed expression patterns consistent with an immunodysregulatory phenotype that were appropriately modified through JAK inhibition.ConclusionsGain-of-function variants in STAT4 caused DPM in the families that we studied. The JAK inhibitor ruxolitinib attenuated the dermatologic and inflammatory phenotype in vitro and in the affected family members. (Funded by the American Academy of Allergy, Asthma, and Immunology Foundation and others.).
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- 2023
5. Towards Transcervical Ultrasound Image Guidance for Transoral Robotic Surgery
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Chen, Wanwen, Kalia, Megha, Zeng, Qi, Pang, Emily H. T., Bagherinasab, Razeyeh, Milner, Thomas D., Sabiq, Farahna, Prisman, Eitan, and Salcudean, Septimiu E.
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Computer Science - Robotics ,Computer Science - Human-Computer Interaction - Abstract
Purpose: Trans-oral robotic surgery (TORS) using the da Vinci surgical robot is a new minimally-invasive surgery method to treat oropharyngeal tumors, but it is a challenging operation. Augmented reality (AR) based on intra-operative ultrasound (US) has the potential to enhance the visualization of the anatomy and cancerous tumors to provide additional tools for decision-making in surgery. Methods: We propose and carry out preliminary evaluations of a US-guided AR system for TORS, with the transducer placed on the neck for a transcervical view. Firstly, we perform a novel MRI-transcervical 3D US registration study. Secondly, we develop a US-robot calibration method with an optical tracker and an AR system to display the anatomy mesh model in the real-time endoscope images inside the surgeon console. Results: Our AR system reaches a mean projection error of 26.81 and 27.85 pixels for the projection from the US to stereo cameras in a water bath experiment. The average target registration error for MRI to 3D US is 8.90 mm for the 3D US transducer and 5.85 mm for freehand 3D US, and the average distance between the vessel centerlines is 2.32 mm. Conclusion: We demonstrate the first proof-of-concept transcervical US-guided AR system for TORS and the feasibility of trans-cervical 3D US-MRI registration. Our results show that trans-cervical 3D US is a promising technique for TORS image guidance., Comment: 12 pages, 8 figures. Accepted by Information Processing for Computer Assisted Interventions (IPCAI 2023)
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- 2022
6. Surgical Treatment of Patellar Tendinopathy/Osgood–Schlatter’s Disease
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Shubert, Daniel, Hartnett, Davis A., Milner, John D., DeFroda, Steven F., Frank, Rachel, Section editor, Nuelle, Clayton, Section editor, Sherman, Seth L., editor, Chahla, Jorge, editor, LaPrade, Robert F., editor, and Rodeo, Scott A., editor
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- 2024
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7. Towards transcervical ultrasound-guided transoral robotic surgery
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Kwon, Jamie JY, Milner, Thomas D, Kürten, Cornelius, Pang, Emily HT, Chen, Wanwen, Tran, Khanh Linh, Wilson, Don, Dimond, Dennis, Salcudean, Septimiu E, and Prisman, Eitan
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- 2025
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8. The effects of pre-operative anti-osteoporotic use on total joint arthroplasty complications: A national database study
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Katz, Luca, Zhang, Helen, Ireland, Piper, Anuszewski, Maguire, Milner, John D., Liu, Jonathan, Daniels, Alan H., and Antoci, Valentin
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- 2025
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9. Social and demographic health disparities in shoulder and elbow surgery
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Testa, Edward J., Milner, John D., Penvose, Ian R., Okewunmi, Jeffrey, Schmitt, Phillip, Owens, Brett D., and Paxton, E. Scott
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- 2025
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10. PLCG2 variants in cherubism
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Chester, Jennifer G., Carcamo, Benjamin, Gudis, David A., Bustamante, Daniel, Eisig, Sidney B., Ombrello, Michael J., Chung, Wendy K., and Milner, Joshua D.
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- 2024
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11. Scapula or Fibula?: Prospective data-driven decision criteria for flap selection in mandibular reconstruction planning
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Panchal, Maharshi, Zaraska, Katrina, Milner, Thomas D., Tran, Khanh Linh, Hodgson, Antony, Fels, Sidney, Durham, James Scott, and Prisman, Eitan
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- 2025
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12. COVID-19 Vaccination in Patients with Inborn Errors of Immunity Reduces Hospitalization and Critical Care Needs Related to COVID-19: a USIDNET Report
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McDonnell, John, Cousins, Kimberley, Younger, M. Elizabeth M., Lane, Adam, Abolhassani, Hassan, Abraham, Roshini S., Al-Tamemi, Salem, Aldave-Becerra, Juan Carlos, Al-Faris, Eman Hesham, Alfaro-Murillo, Alberto, AlKhater, Suzan A., Alsaati, Nouf, Doss, Alexa Michelle Altman, Anderson, Melissa, Angarola, Ernestina, Ariue, Barbara, Arnold, Danielle E., Assa’ad, Amal H., Aytekin, Caner, Bank, Meaghan, Bergerson, Jenna R. E., Bleesing, Jack, Boesing, John, Bouso, Carolina, Brodszki, Nicholas, Cabanillas, Diana, Cady, Carol, Callahan, Meghan A., Caorsi, Roberta, Carbone, Javier, Carrabba, Maria, Castagnoli, Riccardo, Catanzaro, Jason R., Chan, Samantha, Chandra, Sharat, Chapdelaine, Hugo, Chavoshzadeh, Zahra, Chong, Hey Jin, Connors, Lori, Consonni, Filippo, Correa-Jimenez, Oscar, Cunningham-Rundles, Charlotte, D’Astous-Gauthier, Katherine, Delmonte, Ottavia Maria, Demirdag, Yesim Yilmaz, Deshpande, Deepti R., Diaz-Cabrera, Natalie M., Dimitriades, Victoria R., El-Owaidy, Rasha, ElGhazali, Gehad, Al-Hammadi, Suleiman, Fabio, Giovanna, Faure, Astrid Schellnast, Feng, Jin, Fernandez, James M., Fill, Lauren, Franco, Guacira R., Frenck, Robert W., Fuleihan, Ramsay L., Giardino, Giuliana, Galant-Swafford, Jessica, Gambineri, Eleonora, Garabedian, Elizabeth K., Geerlinks, Ashley V., Goudouris, Ekaterini, Grecco, Octavio, Pan-Hammarström, Qiang, Khani, Hedieh Haji Khodaverdi, Hammarström, Lennart, Hartog, Nicholas L., Heimall, Jennifer, Hernandez-Molina, Gabriela, Horner, Caroline C., Hostoffer, Robert W., Hristova, Nataliya, Hsiao, Kuang-Chih, Ivankovich-Escoto, Gabriela, Jaber, Faris, Jalil, Maaz, Jamee, Mahnaz, Jean, Tiffany, Jeong, Stephanie, Jhaveri, Devi, Jordan, Michael B., Joshi, Avni Y., Kalkat, Amanpreet, Kanarek, Henry J., Kellner, Erinn S., Khojah, Amer, Khoury, Ruby, Kokron, Cristina M., Kumar, Ashish, Lecerf, Kelsey, Lehman, Heather K., Leiding, Jennifer W., Lesmana, Harry, Lim, Xin Rong, Lopes, Joao Pedro, López, Ana Laura, Tarquini, Lucia, Lundgren, Ingrid S., Magnusson, Julieann, Marinho, Ana Karolina B. B., Marseglia, Gian Luigi, Martone, Giulia M., Mechtler, Annamaria G., Mendonca, Leonardo, Milner, Joshua D., Mustillo, Peter J., Naderi, Asal Gharib, Naviglio, Samuele, Nell, Jeremy, Niebur, Hana B., Notarangelo, Luigi, Oleastro, Matias, Ortega-López, María Claudia, Patel, Neil R., Petrovic, Gordana, Pignata, Claudio, Porras, Oscar, Prince, Benjamin T., Puck, Jennifer M., Qamar, Nashmia, Rabusin, Marco, Raje, Nikita, Regairaz, Lorena, Risma, Kimberly A., Ristagno, Elizabeth H., Routes, John, Roxo-Junior, Persio, Salemi, Negin, Scalchunes, Christopher, Schuval, Susan J., Seneviratne, Suranjith L., Shankar, Ashwin, Sherkat, Roya, Shin, Junghee Jenny, Siddiqi, Abeer, Signa, Sara, Sobh, Ali, Lima, Fabiana Mascarenhas Souza, Stenehjem, Kristen K., Tam, Jonathan S., Tang, Monica, Barros, Myrthes Toledo, Verbsky, James, Vergadi, Eleni, Voelker, Dayne H., Volpi, Stefano, Wall, Luke A., Wang, Christine, Williams, Kelli W., Wu, Eveline Y., Wu, Shan Shan, Zhou, Jessie J., Cook, Alexandria, Sullivan, Kathleen E., and Marsh, Rebecca
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- 2024
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13. Regulation of MYC by CARD14 in human epithelium is a determinant of epidermal homeostasis and disease
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DeVore, Stanley B., Schuetz, Matthew, Alvey, Lauren, Lujan, Henry, Ochayon, David E., Williams, Lindsey, Chang, Wan Chi, Filuta, Alyssa, Ruff, Brandy, Kothari, Arjun, Hahn, Jennifer M., Brandt, Eric, Satish, Latha, Roskin, Krishna, Herr, Andrew B., Biagini, Jocelyn M., Martin, Lisa J., Cagdas, Deniz, Keles, Sevgi, Milner, Joshua D., Supp, Dorothy M., and Khurana Hershey, Gurjit K.
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- 2024
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14. TH2-driven manifestations of inborn errors of immunity
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James, Alyssa E., Abdalgani, Manar, Khoury, Paneez, Freeman, Alexandra F., and Milner, Joshua D.
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- 2024
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15. Mast cell activation syndrome: Current understanding and research needs
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Castells, Mariana, Giannetti, Matthew P., Hamilton, Matthew J., Novak, Peter, Pozdnyakova, Olga, Nicoloro-SantaBarbara, Jennifer, Jennings, Susan V., Francomano, Clair, Kim, Brian, Glover, Sarah C., Galli, Stephen J., Maitland, Anne, White, Andrew, Abonia, J. Pablo, Slee, Valerie, Valent, Peter, Butterfield, Joseph H., Carter, Melody, Metcalfe, Dean D., Akin, Cem, Lyons, Jonathan J., Togias, Alkis, Wheatley, Lisa, and Milner, Joshua D.
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- 2024
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16. Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection
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Abel, Laurent, Aiuti, Alessandro, Al-Muhsen, Saleh, Al-Mulla, Fahd, Amara, Ali, Anderson, Mark S., Andreakos, Evangelos, Arias, Andrés A., Arkin, Lisa M., Feldman, Hagit Baris, Bastard, Paul, Belot, Alexandre, Biggs, Catherine M., Bogunovic, Dusan, Bolze, Alexandre, Bondarenko, Anastasiia, Borghesi, Alessandro, Bousfiha, Ahmed A., Brodin, Petter, Bryceson, Yenan, Butte, Manish J., Casanova, Jean-Laurent, Casari, Giorgio, Christodoulou, John, Cobat, Aurélie, Colobran, Roger, Condino-Neto, Antonio, Constantinescu, Stefan N., Cooper, Megan A., Dalgard, Clifton L., Desai, Murkesh, Drolet, Beth A., Duval, Xavier, El Baghdadi, Jamila, Eloy, Philippine, Espinosa-Padilla, Sara, Fellay, Jacques, Flores, Carlos, Franco, José Luis, Froidure, Antoine, Gorochov, Guy, Gregersen, Peter K., Grimbacher, Bodo, Haerynck, Filomeen, Hagin, David, Halwani, Rabih, Hammarström, Lennart, Heath, James R., Hsieh, Elena W.Y., Husebye, Eystein, Imai, Kohsuke, Itan, Yuval, Jouanguy, Emmanuelle, Kaja, Elżbieta, Karamitros, Timokratis, Kisand, Kai, Ku, Cheng-Lung, Lau, Yu-Lung, Ling, Yun, Lucas, Carrie L., Maniatis, Tom, Mansouri, Davood, Maródi, László, Mentré, France, Meyts, Isabelle, Milner, Joshua D., Mironska, Kristina, Mogensen, Trine H., Morio, Tomohiro, Ng, Lisa F.P., Notarangelo, Luigi D., Novelli, Antonio, Novelli, Giuseppe, O'Farrelly, Cliona, Okada, Satoshi, Okamoto, Keisuke, Ozcelik, Tayfun, Pan-Hammarström, Qiang, Pape, Jean W., Perez de Diego, Rebeca, Perez-Tur, Jordi, Perlin, David S., Pesole, Graziano, Planas, Anna M., Prando, Carolina, Pujol, Aurora, Puel, Anne, Quintana-Murci, Lluis, Ramaswamy, Sathishkumar, Renia, Laurent, Resnick, Igor, Rodríguez-Gallego, Carlos, Sancho-Shimizu, Vanessa, Sediva, Anna, Seppänen, Mikko R.J., Shahrooei, Mohammad, Shcherbina, Anna, Slaby, Ondrej, Snow, Andrew L., Soler-Palacín, Pere, Soumelis, Vassili, Spaan, András N., Tancevski, Ivan, Tangye, Stuart G., Tayoun, Ahmad Abou, Temel, Şehime Gülsün, Thorball, Christian, Tiberghien, Pierre, Trouillet-Assant, Sophie, Turvey, Stuart E., Uddin, K. M. Furkan, Uddin, Mohammed J., van de Beek, Diederik, Vinh, Donald C., von Bernuth, Horst, Wauters, Joost, Zatz, Mayana, Zawadzki, Pawel, Zhang, Qian, Zhang, Shen-Ying, Bureau, Serge, Vacher, Yannick, Gysembergh-Houal, Anne, Demerville, Lauren, Benleulmi-Chaachoua, Abla, Abad, Sebastien, Abassi, Radhiya, Abdellaoui, Abdelrafie, Abdelmalek, Abdelkrim, Abdoul, Hendy, Abergel, Helene, Abeud, Fariza, Abgrall, Sophie, Abisror, Noemie, Adechian, Marylise, Aderdour, Nordine, Admane, Hakeem Farid, Adnet, Frederic, Afritt, Sara, Agostini, Helene, Aguilar, Claire, Agut, Sophie, Aiello, Tommaso Francesco, Kaci, Marc Ait, Oufella, Hafid Ait, Ajeenthiravasan, Gokula, Alauzy, Virginie, Alby-Laurent, Fanny, Allard, Lucie, Alyanakian, Marie-Alexandra, Borrero, Blanca Amador, Amam, Sabrina, Amrouche, Lucile, Andronikof, Marc, Anglicheau, Dany, Anguel, Nadia, Annane, Djillali, Aounzou, Mohammed, Aparicio, Caroline, Aratus, Gladys, Arlet, Jean-Benoit, Arzoine, Jeremy, Aslangul, Elisabeth, Assefi, Mona, Aubry, Adeline, Audiffred, Laetitia, Audureau, Etienne, Auger, Christelle Nathalie, Auregan, Jean-Charles, Awotar, Celine, Milla, Sonia Ayllon, Azan, Delphine, Azemar, Laurene, Azzouguen, Billal, Elrufaai, Marwa Bachir, Badsi, Aïda, Bakouboula, Prissile, Balcerowiak, Coline, Balde, Fanta, Baldivia, Elodie, Bangamingo, Eliane-Flore, Baptiste, Amandine, Baran-Marszak, Fanny, Barau, Caroline, Barget, Nathalie, Baronnet, Flore, Barthelemy, Romain, Baudel, Jean-Luc, Baudry, Camille, Baudry, Elodie, Beaugerie, Laurent, Belamri, Adel, Belaube, Nicolas, Belilita, Rhida, Bellassen, Pierre, Belmokhtar, Rawan, Beltran, Isabel, Benainous, Ruben, Benallaoua, Mourad, Benamouzig, Robert, Benbara, Amélie, Benhida, Jaouad, Benkhelouf, Anis, Benlagha, Jihene, Benmostafa, Chahinez, Benothmane, Skander, Bentifraouine, Miassa, Berard, Laurence, Bernier, Quentin, Berti, Enora, Bertier, Astrid, Berton, Laure, Bessis, Simon, Beurton, Alexandra, Bianco, Celine, Bianquis, Clara, Bidar, Frank, Blanche, Philippe, Blayau, Clarisse, Bleibtreu, Alexandre, Blin, Emmanuelle, Bloch-Queyrat, Coralie, Boissier, Marie-Christophe, Bollens, Diane, Bolzoni, Marion, Bompard, Rudy pierre, Bonnet, Nicolas, Bonnouvrier, Justine, Botha, Shirmonecrystal, Boucenna, Wissam, Bouchama, Fatiha, Bouchaud, Olivier, Bouchghoul, Hanane, Boudjebla, Taoueslylia, Boudjema, Noel, Bouffard, Catherine, Bougle, Adrien, Bouguerra, Meriem, Bouras, Leila, Bourcier, Agnes, Durand, Anne Bourgarit, Bourrier, Anne, Bouscarat, Fabrice, Bouvry, Diane, Bouziri, Nesrine, Bouzrara, Ons, Bribier, Sarah, Brugier, Delphine, Brunel, Melanie, Bui, Eida, Buisson, Anne, Bukreyeva, Iryna, Bureau, Côme, Cadranel, Jacques, Cailhol, Johann, Calin, Ruxandra, Vega, Clara Campos, Canavaggio, Pauline, Cancella, Marta, Cantin, Delphine, Cao, Albert, Carbillon, Lionel, Carlier, Nicolas, Cassard, Clementine, Castor, Guylaine, Cauchy, Marion, Cha, Olivier, Chaigne, Benjamin, Challal, Salima, Champion, Karine, Chariot, Patrick, Chas, Julie, Chauveau, Simon, Chauvin, Anthony, Chauvin, Clement, Chavarot, Nathalie, Chebbout, Kamélia, Cherai, Mustapha, Cherubini, Ilaria, Chevalier, Amelie, Chiarabini, Thibault, Chinet, Thierry, Chocron, Richard, Choinier, Pascaline, Chommeloux, Juliette, Choquet, Christophe, Choupeaux, Laure, Chousterman, Benjamin, Ciocan, Dragosmarius, Clarke, Ada, Clavere, Gaëlle, Clavier, Florian, Clement, Karine, Clerc, Sebastien, Cohen, Yves, Cohen, Fleur, Cohen, Adrien, Coilly, Audrey, Colboc, Hester, Colin, Pauline, Collet, Magalie, Comarmond, Chloé, Combacon, Emeline, Combes, Alain, Comparon, Celine, Constantin, Jean-Michel, Cordel, Hugues, Cordier, Anne-Gael, Costantini, Adrien, Chalumeau, Nathalie Costedoat, Couffignal, Camille, Coupeau, Doriane, Creange, Alain, Lamarre, Yannie Cuvillier, Da Silveira, Charlène, Guibal El Kayani, Sandrine Dautheville, De Castro, Nathalie, De Rycke, Yann, Del Pozo, Lucie, Delannoy, Quentin, Delay, Mathieu, Deleris, Robin, Delforge, Juliette, Delphine, Laëtitia, Demare, Noemie, Demeret, Sophie, Demoule, Alexandre, Deniau, Aurore, Depret, François, Derolez, Sophie, Derradji, Ouda, Derridj, Nawal, Descamps, Vincent, Deschamps, Lydia, Desconclois, Celine, Desnos, Cyrielle, Desongins, Karine, Dhote, Robin, Diallo, Benjamin, Didier, Morgane, Diemer, Myriam, Diez, Stephane, Djadi-Prat, Juliette, Djamouri Monnory, Fatima-Zohra, Djebara, Siham, Djebra, Naoual, Djietcheu, Minette, Djillali, Hadjer, Djouadi, Nouara, Donneger, Severine, Santos, Catarina Dos, Dournon, Nathalie, Dres, Martin, Droctove, Laura, Drogrey, Marie, Dropy, Margot, Drouet, Elodie, Dubosq, Valérie, Dubreucq, Evelyne, Dubus, Estelle, Duchemann, Boris, Duchenoy, Thibault, Dudoignon, Emmanuel, Dufau, Romain, Dumas, Florence, Duran, Clara, Duron, Emmanuelle, Durrbach, Antoine, Duvivier, Claudine, Ebstein, Nathan, El Khalifa, Jihane, Elabbadi, Alexandre, Elie, Caroline, Ernotte, Gabriel, Esling, Anne, Etienne, Martin, Eyer, Xavier, Fartoukh, Muriel Sarah, Fayali, Takoua, Fermaut, Marion, Fiorentino, Arianna, Fliss, Souha, Fournier, Marie-Céline, Fournier, Benjamin, Francois, Hélène, Freynet, Olivia, Frigout, Yvann, Fromont, Isaure, Fuentes, Axelle, Furet, Thomas, Galand, Joris, Garnier, Marc, Gaubert, Agnes, Gaudry, Stéphane, Gaugain, Samuel, Gauthier, Damien, Gautier, Maxime, Georgin-Lavialle, Sophie, Geromin, Daniela, Ghalayini, Mohamed, Ghaleh, Bijan, Ghezal, Myriam, Gibelin, Aude, Gimeno, Linda, Girard, Benoit, Leprieur, Bénédicte Giroux, Gomes, Doryan, Gomes-Pires, Elisabete, Gouge, Anne, Gouja, Amel, Goulet, Helene, Goupil, Sylvain, De Bouille, Jeanne Goupil, Gras, Julien, Greffe, Segolene, Grimaldi, Lamiae, Guedeney, Paul, Guidet, Bertrand, Guillo, Matthias, Gulczynski, Mariechristelle, Hadjam, Tassadit, Haguenauer, Didier, Hammal, Soumeya, Hammoudi, Nadjib, Hanon, Olivier, Harrois, Anarole, Hausfater, Pierre, Hautem, Coraline, Hekimian, Guillaume, Heming, Nicholas, Hermine, Olivier, Ho, Sylvie, Houllier, Marie, Huot, Benjamin, Huscenot, Tessa, Saied, Wafa Ibn, Ikherbane, Ghilas, Imarazene, Meriem, Ingiliz, Patrick, Iratni, Lina, Jaureguiberry, Stephane, Jean-Marc, Jean-Francois, Jeyarajasingham, Deleena, Jouany, Pauline, Jouis, Veronique, Jourdaine, Clement, Kafif, Ouifiya, Kallala, Rim, Katsahian, Sandrine, Kelesyan, Lilit, Keo, Vixra, Ketz, Flora, Khamis, Warda, Khelili, Enfel, Khellaf, Mehdi, Kotokpo Youkou, Christy Gaëlla, Kounis, Ilias, Kpalma, Gaelle, Krause, Jessica, Labbe, Vincent, Lacombe, Karine, Lacorte, Jean-Marc, Lafont, Anne Gaelle, Lafont, Emmanuel, Lagha, Lynda, Lamhaut, Lionel, Lancelot, Aymeric, Landman, Cecilia, Lanternier, Fanny, Larcheveque, Cecile, Combe, Caroline Lascoux, Lassel, Ludovic, Laverdant, Benjamin, Lavergne, Christophe, Lavillegrand, Jean-Rémi, Lazureanu, Pompilia, Le Guennec, Loïc, Leberre, Lamia, Leblanc, Claire, Leboyer, Marion, Lecomte, Francois, Lecorre, Marine, Leenhardt, Romain, Lefebvre, Marylou, Lefebvre, Bénédicte, Legendre, Paul, Leger, Anne, Legros, Laurence, Legrosse, Justyna, Lehuunghia, Sébastien, Lemarec, Julien, Leporrier-Ext, Jeremie, Lesein, Manon, Lesur, Hubert, Levy, Vincent, Levy, Albert, Lopes, Edwige, Lopes, Amanda, Lopez, Vanessa, Lopinto, Julien, Lortholary, Olivier, Louadah, Badr, Loze, Bénédicte, Lucas, Marie-Laure, Lucasamichi, Axelle, Luong, Liem Binh, Magazimama-Ext, Arouna, Maingret, David, Mameri, Lakhdar, Manivet, Philippe, Mansouri, Cylia, Marcault, Estelle, Marey, Jonathan, Marin, Nathalie, Marois, Clémence, Martin, Olivier, Martineau, Lou, Martinez-Lopez, Cannelle, Martyniuck, Pierre, De Farcy, Pauline Mary, Marzouk, Nessrine, Masmoudi, Rafik, Mebazaa, Alexandre, Mechai, Frédéric, Mecozzi, Fabio, Mediouni, Chamseddine, Megarbane, Bruno, Meghadecha, Mohamed, Mejean, Élodie, Mekinian, Arsene, Abdelhadi, Nour Mekki, Mekni, Rania, Meliti, Thinhinan Sabrina, Lima, Breno Melo, Meng, Paris, Merbah, Soraya, Messani, Fadhila, Messaoudi, Yasmine, Mewasing, Baboo-Irwinsingh, Meziane, Lydia, Michelot-Burger, Carole, Mignot, Françoise, Minka, Fadi Hillary, Miyara, Makoto, Moine, Pierre, Molina, Jean-Michel, Montegnies-Boulet, Anaïs, Monti, Alexandra, Montlahuc, Claire, Montout, Anne-Lise, Moores, Alexandre, Morbieu, Caroline, Mortelette, Helene, Mouly, Stéphane, Muzaffar, Rosita, Nacerddine, Cherifa Iness, Nadal, Marine, Nadif, Hajer, Nassarmadji, Kladoum, Natella, Pierre, Ndingamondze, Sandrine, Neraal, Stefan, Nguyen, Caroline, N'Guyen, Bao, Larmurier, Isabelle Nion, Nlomenyengue, Luc, Noel, Nicolas, Nunes, Hilario, Omar, Edris, Ouazene, Zineb, Ouedraogo, Elise, Ouelaa, Wassila, Oukhedouma, Anissa, Amara, Yasmina Ould, Oya, Herve, Oziel, Johanna, Padilla, Thomas, Paillaud, Elena, Paiva, Solenne, Parfait, Beatrice, Parize, Perrine, Parizot, Christophe, Parrot, Antoine, Pavot, Arthur, Peaudecerf, Laetitia, Pene, Frédéric, Pepin, Marion, Pernet, Julie, Pernin, Claire, Petit, Mylène, Peyrony, Olivier, Pietri, Marie-Pierre, Pietri, Olivia, De Chambrun, Marc Pineton, Pinson, Michelle, Pintado, Claire, Piquard, Valentine, Pires, Christine, Planquette, Benjamin, Poirier, Sandrine, Pomel, Anne-Laure, Pons, Stéphanie, Ponscarme, Diane, Pourcelot, Annegaelle, Pourcher, Valérie, Pouvaret, Anne, Prever, Florian, Previlon, Miresta, Prevost, Margot, Provoost, Marie-Julie, Quemeneur, Cyril, Rafat, Cédric, Rami, Agathe, Ranque, Brigitte, Raphael, Maurice, Raphalen, Jean Herle, Rastoin, Anna, Raux, Mathieu, Rebai, Amani, Reby, Michael, Regent, Alexis, Regrag, Asma, Resche-Rigon, Matthieu, Ressaire, Quentin, Richard, Christian, Richard, Mariecaroline, Robert, Maxence, Rohaut, Benjamin, Rolland-Debord, Camille, Ropers, Jacques, Roque-Afonso, Anne-Marie, Rosso, Charlotte, Rousseaux, Mélanie, Rousseaux, Nabila, Roux, Swasti, Roux, Lorène, Rouzaud, Claire, Rozes, Antoine, Rubenstein, Emma, Sabate, Jean-Marc, Sabet, Sheila, Sacleux, Sophie-Caroline, Kermanach, Nathalie Saidenberg, Saliba, Faouzi, Salmon, Dominique, Savale, Laurent, Savary, Guillaume, Sberro, Rebecca, Scemla, Anne, Schlemmer, Frederic, Schwartz, Mathieu, Sedfi, Saïd, Sefir-Kribel, Samia, Seksik, Philippe, Sellier, Pierre, Selves, Agathe, Sembach, Nicole, Semerano, Luca, Senat, Marie-Victoire, Sene, Damien, Serris, Alexandra, Sese, Lucile, Sghiouar, Naima, Sigaux, Johanna, Siguier, Martin, Silvain, Johanne, Simon, Noémie, Simon, Tabassome, Skandri, Lina Innes, Slimani, Miassa, Snauwaert, Aurélie, Sokol, Harry, Soliman, Heithem, Soltani, Nisrine, Soyer, Benjamin, Steg, Gabriel, Suarez, Lydia, Szwebel, Tali-Anne, Taffame, Kossi, Tandjaoui-Lambiotte, Yacine, Tantet, Claire, Tateo, Mariagrazia, Theodose, Igor, Thiebaud, Pierre clement, Thomas, Caroline, Tiercelet, Kelly, Tisserand, Julie, Tomczak, Carole, Torelino, Krystel, Touam-Ext, Fatima, Toumi, Lilia, Toury, Gustave, Toy-Miou, Mireille, Dinh Thanh Lien, Olivia Tran, Trandinh, Alexy, Treluyer, Jean-Marc, Trinque, Baptiste, Truchot, Jennifer, Tubach, Florence, Tubiana, Sarah, Tunesi, Simone, Turpin, Matthieu, Turpin, Agathe, Urbina, Tomas, Narvaez, Rafael Usubillaga, Uzunhan, Yurdagul, Vaittinadaayar, Prabakar, Valent, Arnaud, Valentian, Maelle, Valin, Nadia, Vallet, Hélène, Vaz, Marina, Vazquezibarra, Miguel-Alejandro, Vedie, Benoit, Velly, Laetitia, Verstuyft, Celine, Viallette, Cedric, Vicaut, Eric, Vignes, Dorothee, Vimpere, Damien, Virlouvet, Myriam, Voiriot, Guillaume, Voisot, Lena, Weiss, Emmanuel, Weiss, Nicolas, Winchenne, Anaïs, Yordanov, Youri, Zafrani, Lara, Zaidan, Mohamad, Zaidi, Wissem, Zak, Cathia, Zarhrate-Ghoul, Aida, Zatout, Ouassila, Zeino, Suzanne, Zeitouni, Michel, Zemirli, Naïma, Zerah, Lorene, Zia, Ounsa, Ziol, Marianne, Zolario, Oceane, Zuber, Julien, Andrejak, Claire, Angoulvant, François, Bachelet, Delphine, Bartoli, Marie, Basmaci, Romain, Behillil, Sylvie, Beluze, Marine, Benkerrou, Dehbia, Bhavsar, Krishna, Bouadma, Lila, Bouchez, Sabelline, Bouscambert, Maude, Cervantes-Gonzalez, Minerva, Chair, Anissa, Chirouze, Catherine, Coelho, Alexandra, Couffin-Cadiergues, Sandrine, d’Ortenzio, Eric, Debray, Marie-Pierre, Deconinck, Laurene, Deplanque, Dominique, Descamps, Diane, Desvallée, Mathilde, Diallo, Alpha, Diouf, Alphonsine, Dorival, Céline, Dubos, François, Elharrar, Brigitte, Enouf, Vincent, Esperou, Hélène, Esposito-Farese, Marina, Etienne, Manuel, Devouge, Eglantine Ferrand, Gault, Nathalie, Gaymard, Alexandre, Ghosn, Jade, Gigante, Tristan, Gilg, Morgane, Guedj, Jérémie, Hoctin, Alexandre, Hoffmann, Isabelle, Houas, Ikram, Hulot, Jean-Sébastien, Jaafoura, Salma, Kaguelidou, Florentia, Kali, Sabrina, Khalil, Antoine, Khan, Coralie, Laouénan, Cédric, Laribi, Samira, Le, Minh, Le Hingrat, Quentin, Le Mestre, Soizic, Le Nagard, Hervé, Lescure, François-Xavier, Letrou, Sophie, Levy, Yves, Lina, Bruno, Lingas, Guillaume, Lucet, Jean-Christophe, Malvy, Denis, Mambert, Marina, Meziane, Amina, Mouquet, Hugo, Mullaert, Jimmy, Neant, Nadège, Nguyen, Duc, Noret, Marion, Nseir, Saad, Papadopoulos, Aurélie, Paul, Christelle, Peiffer-Smadja, Nathan, Perpoint, Thomas, Petrov-Sanchez, Ventzislava, Peytavin, Gilles, Pham, Huong, Picone, Olivier, Puéchal, Oriane, Rabaud, Christian, Rosa-Calatrava, Manuel, Rossignol, Bénédicte, Rossignol, Patrick, Roy, Carine, Schneider, Marion, Su, Richa, Tardivon, Coralie, Tellier, Marie-Capucine, Téoulé, François, Terrier, Olivier, Timsit, Jean-François, Tual, Christelle, Van Der Werf, Sylvie, Vanel, Noémie, Veislinger, Aurélie, Visseaux, Benoit, Wiedemann, Aurélie, Yazdanpanah, Yazdan, Alavoine, Loubna, Burdet, Charles, Charpentier, Charlotte, Dechanet, Aline, Ecobichon, Jean-Luc, Frezouls, Wahiba, Houhou, Nadhira, Lehacaut, Jonathan, Manchon, Pauline, Nouroudine, Mariama, Quintin, Caroline, Thy, Michael, van der Werf, Sylvie, Vignali, Valérie, Chahine, Abir, Waucquier, Nawal, Migaud, Maria-Claire, Djossou, Félix, Mergeay-Fabre, Mayka, Lucarelli, Aude, Demar, Magalie, Bruneau, Léa, Gérardin, Patrick, Maillot, Adrien, Payet, Christine, Laviolle, Bruno, Laine, Fabrice, Paris, Christophe, Desille-Dugast, Mireille, Fouchard, Julie, Pistone, Thierry, Perreau, Pauline, Gissot, Valérie, Goas, Carole L.E., Montagne, Samatha, Richard, Lucie, Bouiller, Kévin, Desmarets, Maxime, Meunier, Alexandre, Bourgeon, Marilou, Lefévre, Benjamin, Jeulin, Hélène, Legrand, Karine, Lomazzi, Sandra, Tardy, Bernard, Gagneux-Brunon, Amandine, Bertholon, Frédérique, Botelho-Nevers, Elisabeth, Kouakam, Christelle, Nicolas, Leturque, Roufai, Layidé, Amat, Karine, Espérou, Hélène, Hendou, Samia, Foti, Giuseppe, Citerio, Giuseppe, Contro, Ernesto, Pesci, Alberto, Valsecchi, Maria Grazia, Cazzaniga, Marina, Bellani, Giacomo, Abad, Jorge, Accordino, Giulia, Angelini, Micol, Aguilera-Albesa, Sergio, Aguiló-Cucurull, Aina, Özkan, Esra Akyüz, Darazam, Ilad Alavi, Roblero Albisures, Jonathan Antonio, Aldave, Juan C., Ramos, Miquel Alfonso, Khan, Taj Ali, Aliberti, Anna, Nadji, Seyed Alireza, Alkan, Gulsum, AlKhater, Suzan A., Allardet-Servent, Jerome, Allende, Luis M., Alonso-Arias, Rebeca, Alshahrani, Mohammed S., Alsina, Laia, Amoura, Zahir, Antolí, Arnau, Arrestier, Romain, Aubart, Mélodie, Auguet, Teresa, Avramenko, Iryna, Aytekin, Gökhan, Azot, Axelle, Bahram, Seiamak, Bajolle, Fanny, Baldanti, Fausto, Baldolli, Aurélie, Ballester, Maite, Barrou, Benoit, Barzaghi, Federica, Basso, Sabrina, Bayhan, Gulsum Iclal, Bezrodnik, Liliana, Bilbao, Agurtzane, Blanchard-Rohner, Geraldine, Blanco, Ignacio, Blandinières, Adeline, Blázquez-Gamero, Daniel, Bloomfield, Marketa, Bolivar-Prados, Mireia, Borie, Raphael, Botdhlo-Nevers, Elisabeth, Bousquet, Aurore, Boutolleau, David, Bouvattier, Claire, Boyarchuk, Oksana, Bravais, Juliette, Briones, M. Luisa, Brunner, Marie-Eve, Bruno, Raffaele, Bueno, Maria Rita P., Bukhari, Huda, Bustamante, Jacinta, Cáceres Agra, Juan José, Capra, Ruggero, Carapito, Raphael, Carrabba, Maria, Casasnovas, Carlos, Caseris, Marion, Cassaniti, Irene, Castelle, Martin, Castelli, Francesco, Castillo de Vera, Martín, Castro, Mateus V., Catherinot, Emilie, Celik, Jale Bengi, Ceschi, Alessandro, Chalumeau, Martin, Charbit, Bruno, Boulanger, Cécile, Clavé, Père, Clotet, Bonaventura, Codina, Anna, Comarmond, Cloé, Comoli, Patrizia, Corsico, Angelo G., Coşkuner, Taner, Cvetkovski, Aleksandar, Cyrus, Cyril, Dalmau, David, Danion, François, Darley, David Ross, Das, Vincent, Dauby, Nicolas, Dauger, Stéphane, De Munte, Paul, de Pontual, Loic, Dehban, Amin, Delplancq, Geoffroy, Desguerre, Isabelle, Di Sabatino, Antonio, Diehl, Jean-Luc, Dobbelaere, Stephanie, Domínguez-Garrido, Elena, Dubost, Clément, Ekwall, Olov, Bozdemir, Şefika Elmas, Elnagdy, Marwa H., Emiroglu, Melike, Endo, Akifumi, Erdeniz, Emine Hafize, Aytekin, Selma Erol, Etxart Lasa, Maria Pilar, Euvrard, Romain, Fabio, Giovanna, Faivre, Laurence, Falck, Antonin, Fartoukh, Muriel, Faure, Morgane, Arquero, Miguel Fernandez, Ferrer, Ricard, Ferreres, Jose, Francois, Bruno, Fumadó, Victoria, Fung, Kitty S.C., Fusco, Francesca, Gagro, Alenka, Solis, Blanca Garcia, Garçon, Pierre, Gaussem, Pascale, Gayretli, Zeynep, Gil-Herrera, Juana, Gilardin, Laurent, Gatineau, Audrey Giraud, Girona-Alarcón, Mònica, Cifuentes Godínez, Karen Alejandra, Goffard, Jean-Christophe, Gonzales, Nacho, Gonzalez-Granado, Luis I., González-Montelongo, Rafaela, Guerder, Antoine, Gülhan, Belgin, Gumucio, Victor Daniel, Hanitsch, Leif Gunnar, Gunst, Jan, Gut, Marta, Hadjadj, Jérôme, Hancerli, Selda, Hariyan, Tetyana, Hatipoglu, Nevin, Heppekcan, Deniz, Hernandez-Brito, Elisa, Ho, Po-ki, Holanda-Peña, María Soledad, Horcajada, Juan P., Hraiech, Sami, Humbert, Linda, Hung, Ivan F.N., Iglesias, Alejandro D., Íñigo-Campos, Antonio, Jamme, Matthieu, Arranz, María Jesús, Jimeno, Marie-Thérèse, Jordan, Iolanda, Kanık-Yüksek, Saliha, Kara, Yalcin, Karahan, Aydın, Karbuz, Adem, Yasar, Kadriye Kart, Kasapcopur, Ozgur, Kashimada, Kenichi, Keles, Sevgi, Demirkol, Yasemin Kendir, Kido, Yasutoshi, Kizil, Can, Kılıç, Ahmet Osman, Klocperk, Adam, Koutsoukou, Antonia, Król, Zbigniew J., Ksouri, Hatem, Kuentz, Paul, Kwan, Arthur M.C., Kwan, Yat Wah M., Kwok, Janette S.Y., Lagier, Jean-Christophe, Lam, David S.Y., Lampropoulou, Vicky, Le Bourgeois, Fleur, Leo, Yee-Sin, Lopez, Rafael Leon, Leung, Daniel, Levin, Michael, Levy, Michael, Lévy, Romain, Li, Zhi, Lilleri, Daniele, Adrian Bolanos Lima, Edson Jose, Linglart, Agnes, López-Collazo, Eduardo, Lorenzo-Salazar, José M., Louapre, Céline, Lubetzki, Catherine, Lung, Kwok-Cheung, Luyt, Charles-Edouard, Lye, David C., Magnone, Cinthia, Marchioni, Enrico, Marioli, Carola, Marjani, Majid, Marques, Laura, Pereira, Jesus Marquez, Martín-Nalda, Andrea, Pueyo, David Martínez, Martinez-Picado, Javier, Marzana, Iciar, Mata-Martínez, Carmen, Mathian, Alexis, Matos, Larissa R.B., Matthews, Gail V., Mayaux, Julien, McLaughlin-Garcia, Raquel, Meersseman, Philippe, Mège, Jean-Louis, Mekontso-Dessap, Armand, Melki, Isabelle, Meloni, Federica, Meritet, Jean-François, Merlani, Paolo, Akcan, Özge Metin, Mezidi, Mehdi, Migeotte, Isabelle, Millereux, Maude, Million, Matthieu, Mirault, Tristan, Mircher, Clotilde, Mirsaeidi, Mehdi, Mizoguchi, Yoko, Modi, Bhavi P., Mojoli, Francesco, Moncomble, Elsa, Melián, Abián Montesdeoca, Martinez, Antonio Morales, Morandeira, Francisco, Morange, Pierre-Emmanuel, Mordacq, Clémence, Morelle, Guillaume, Mouly, Stéphane J., Muñoz-Barrera, Adrián, Nafati, Cyril, Nagashima, Shintaro, Nakagama, Yu, Neven, Bénédicte, Neves, João Farela, Ng, Yuk-Yung, Hubert Nielly, Medina, Yeray Novoa, Cuadros, Esmeralda Nuñez, Karabela, Semsi Nur, Ocejo-Vinyals, J. Gonzalo, Oualha, Mehdi, Ouedrani, Amani, Özçelik, Tayfun, Ozkaya-Parlakay, Aslinur, Pagani, Michele, Papadaki, Maria, Parola, Philippe, Pascreau, Tiffany, Paul, Stéphane, Paz-Artal, Estela, Pedraza, Sigifredo, González Pellecer, Nancy Carolina, Pellegrini, Silvia, Pérez de Diego, Rebeca, Pérez-Fernández, Xosé Luis, Philippe, Aurélien, Philippot, Quentin, Picod, Adrien, Pineton de Chambrun, Marc, Piralla, Antonio, Planas-Serra, Laura, Ploin, Dominique, Poissy, Julien, Poncelet, Géraldine, Poulakou, Garyphallia, Pouletty, Marie S., Pourshahnazari, Persia, Qiu-Chen, Jia Li, Quentric, Paul, Rambaud, Thomas, Raoult, Didier, Raoult, Violette, Rebillat, Anne-Sophie, Redin, Claire, Resmini, Léa, Ricart, Pilar, Richard, Jean-Christophe, Rigo-Bonnin, Raúl, Rivet, Nadia, Rivière, Jacques G., Rocamora-Blanch, Gemma, Rodero, Mathieu P., Rodrigo, Carlos, Rodriguez, Luis Antonio, Rodriguez-Gallego, Carlos, Rodriguez-Palmero, Agustí, Romero, Carolina Soledad, Rothenbuhler, Anya, Roux, Damien, Rovina, Nikoletta, Rozenberg, Flore, Ruch, Yvon, Ruiz, Montse, Ruiz del Prado, Maria Yolanda, Ruiz-Rodriguez, Juan Carlos, Sabater-Riera, Joan, Saks, Kai, Salagianni, Maria, Sanchez, Oliver, Sánchez-Montalvá, Adrián, Sánchez-Ramón, Silvia, Schidlowski, Laire, Schluter, Agatha, Schmidt, Julien, Schmidt, Matthieu, Schuetz, Catharina, Schweitzer, Cyril E., Scolari, Francesco, Seijo, Luis, Seminario, Analia Gisela, Seng, Piseth, Senoglu, Sevtap, Seppänen, Mikko, Llovich, Alex Serra, Siguret, Virginie, Siouti, Eleni, Smadja, David M., Smith, Nikaia, Sobh, Ali, Solanich, Xavier, Solé-Violán, Jordi, Soler, Catherine, Sözeri, Betül, Stella, Giulia Maria, Stepanovskiy, Yuriy, Stoclin, Annabelle, Taccone, Fabio, Taupin, Jean-Luc, Tavernier, Simon J., Tello, Loreto Vidaur, Terrier, Benjamin, Thiery, Guillaume, Thorn, Karolina, Thumerelle, Caroline, Tipu, Imran, Tolstrup, Martin, Tomasoni, Gabriele, Toubiana, Julie, Alvarez, Josep Trenado, Triantafyllia, Vasiliki, Troya, Jesús, Tsang, Owen T.Y., Tserel, Liina, Tso, Eugene Y.K., Tucci, Alessandra, Tüter Öz, Şadiye Kübra, Ursini, Matilde Valeria, Utsumi, Takanori, Vabres, Pierre, Valencia-Ramos, Juan, Van Den Rym, Ana Maria, Vandernoot, Isabelle, Velez-Santamaria, Valentina, Zuniga Veliz, Silvia Patricia, Vidigal, Mateus C., Viel, Sébastien, Villain, Cédric, Vilaire-Meunier, Marie E., Villar-García, Judit, Vincent, Audrey, Van der Linden, Dimitri, Volokha, Alla, Vuotto, Fanny, Wauters, Els, Wu, Alan K.L., Wu, Tak-Chiu, Yahşi, Aysun, Yesilbas, Osman, Yildiz, Mehmet, Young, Barnaby E., Yükselmiş, Ufuk, Zecca, Marco, Zuccaro, Valentina, Van Praet, Jens, Lambrecht, Bart N., Van Braeckel, Eva, Bosteels, Cédric, Hoste, Levi, Hoste, Eric, Bauters, Fré, De Clercq, Jozefien, Heijmans, Catherine, Slabbynck, Hans, Naesens, Leslie, Florkin, Benoit, Young, Mary-Anne, Willis, Amanda, Lapuente-Suanzes, Paloma, de Andrés-Martín, Ana, Berkell, Matilda, Carelli, Valerio, Fiorentino, Alessia, Malhotra, Surbhi, Mattiaccio, Alessandro, Pippucci, Tommaso, Seri, Marco, Tacconelli, Evelina, van Agtmael, Michiel, Algera, Anne Geke, Appelman, Brent, van Baarle, Frank, Bax, Diane, Beudel, Martijn, Bogaard, Harm Jan, Bomers, Marije, Bonta, Peter, Bos, Lieuwe, Botta, Michela, de Brabander, Justin, de Bree, Godelieve, de Bruin, Sanne, Buis, David T.P., Bugiani, Marianna, Bulle, Esther, Chouchane, Osoul, Cloherty, Alex, Dijkstra, Mirjam, Dongelmans, Dave A., Dujardin, Romein W.G., Elbers, Paul, Fleuren, Lucas, Geerlings, Suzanne, Geijtenbeek, Theo, Girbes, Armand, Goorhuis, Bram, Grobusch, Martin P., Hafkamp, Florianne, Hagens, Laura, Hamann, Jorg, Harris, Vanessa, Hemke, Robert, Hermans, Sabine M., Heunks, Leo, Hollmann, Markus, Horn, Janneke, Hovius, Joppe W., de Jong, Menno D., Koning, Rutger, Lim, Endry H.T., van Mourik, Niels, Nellen, Jeaninne, Nossent, Esther J., Paulus, Frederique, Peters, Edgar, Pina-Fuentes, Dan A.I., van der Poll, Tom, Preckel, Bennedikt, Prins, Jan M., Raasveld, Jorinde, Reijnders, Tom, de Rotte, Maurits C.F. J., Schinkel, Michiel, Schultz, Marcus J., Schrauwen, Femke A.P., Schuurmans, Alex, Schuurmans, Jaap, Sigaloff, Kim, Slim, Marleen A., Smeele, Patrick, Smit, Marry, Stijnis, Cornelis S., Stilma, Willemke, Teunissen, Charlotte, Thoral, Patrick, Tsonas, Anissa M., Tuinman, Pieter R., van der Valk, Marc, Veelo, Denise P., Volleman, Carolien, de Vries, Heder, Vught, Lonneke A., van Vugt, Michèle, Wouters, Dorien, Zwinderman, A.H., Brouwer, Matthijs C., Wiersinga, W. Joost, Vlaar, Alexander P.J., Tompkins, Miranda F., Alba, Camille, Hupalo, Daniel N., Rosenberger, John, Sukumar, Gauthaman, Wilkerson, Matthew D., Zhang, Xijun, Lack, Justin, Oler, Andrew J., Dobbs, Kerry, Delmonte, Ottavia M., Danielson, Jeffrey J., Biondi, Andrea, Bettini, Laura Rachele, D’Angiò, Mariella, Beretta, Ilaria, Imberti, Luisa, Sottini, Alessandra, Quaresima, Virginia, Quiros-Roldan, Eugenia, Rossi, Camillo, Castagnoli, Riccardo, Montagna, Daniela, Licari, Amelia, Marseglia, Gian Luigi, Marchal, Astrid, Cirulli, Elizabeth T., Neveux, Iva, Bellos, Evangelos, Thwaites, Ryan S., Schiabor Barrett, Kelly M., Zhang, Yu, Nemes-Bokun, Ivana, Kalinova, Mariya, Catchpole, Andrew, Lack, Justin B., Chiu, Christopher, and Grzymski, Joseph J.
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- 2024
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17. Ventilatory response to added dead space in infants exposed to second-hand smoke in pregnancy
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Jenkinson, Allan, Bednarczuk, Nadja, Kaltsogianni, Ourania, Williams, Emma E., Lee, Rebecca, Bhat, Ravindra, Dassios, Theodore, Milner, Anthony D., and Greenough, Anne
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- 2023
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18. Dynamic chromatin accessibility licenses STAT5- and STAT6-dependent innate-like function of TH9 cells to promote allergic inflammation
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Son, Aran, Meylan, Francoise, Gomez-Rodriguez, Julio, Kaul, Zenia, Sylvester, McKella, Falduto, Guido H., Vazquez, Estefania, Haque, Tamara, Kitakule, Moses M., Wang, Chujun, Manthiram, Kalpana, Qi, Chen-Feng, Cheng, Jun, Gurram, Rama K., Zhu, Jinfang, Schwartzberg, Pamela, Milner, Joshua D., Frischmeyer-Guerrerio, Pamela A., and Schwartz, Daniella M.
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- 2023
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19. Towards transcervical ultrasound image guidance for transoral robotic surgery
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Chen, Wanwen, Kalia, Megha, Zeng, Qi, Pang, Emily H. T., Bagherinasab, Razeyeh, Milner, Thomas D., Sabiq, Farahna, Prisman, Eitan, and Salcudean, Septimiu E.
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- 2023
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20. Management of Atopy with Dupilumab and Omalizumab in CADINS Disease
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Diaz-Cabrera, Natalie M., Bauman, Bradly M., Iro, Mildred A., Dabbah-Krancher, Gina, Molho-Pessach, Vered, Zlotogorski, Abraham, Shamriz, Oded, Dinur-Schejter, Yael, Sharon, Tatyana Dubnikov, Stepensky, Polina, Tal, Yuval, Eisenstein, Eli M., Pietzsch, Leonora, Schuetz, Catharina, Abreu, Damien, Coughlin, Carrie C., Cooper, Megan A., Milner, Joshua D., Williams, Anthony, Armoni-Weiss, Gil, Snow, Andrew L., and Leiding, Jennifer W.
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- 2024
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21. Inborn Errors of Immunity Contribute to the Burden of Skin Disease and Create Opportunities for Improving the Practice of Dermatology
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Colvin, Annelise, Youssef, Soundos, Noh, Heeju, Wright, Julia, Jumonville, Ghislaine, LaRow Brown, Kathleen, Tatonetti, Nicholas P., Milner, Joshua D., Weng, Chunhua, Bordone, Lindsey A., and Petukhova, Lynn
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- 2024
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22. Sensory neurons promote immune homeostasis in the lung
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Tamari, Masato, Del Bel, Kate L., Ver Heul, Aaron M., Zamidar, Lydia, Orimo, Keisuke, Hoshi, Masato, Trier, Anna M., Yano, Hiroshi, Yang, Ting-Lin, Biggs, Catherine M., Motomura, Kenichiro, Shibuya, Rintaro, Yu, Chuyue D., Xie, Zili, Iriki, Hisato, Wang, Zhen, Auyeung, Kelsey, Damle, Gargi, Demircioglu, Deniz, Gregory, Jill K., Hasson, Dan, Dai, Jinye, Chang, Rui B., Morita, Hideaki, Matsumoto, Kenji, Jain, Sanjay, Van Dyken, Steven, Milner, Joshua D., Bogunovic, Dusan, Hu, Hongzhen, Artis, David, Turvey, Stuart E., and Kim, Brian S.
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- 2024
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23. Splice site and de novo variants can cause PLCG2-associated immune dysregulation with cold urticaria
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Chou, Sophia R., Bailey, Alexis C., Baysac, Kathleen, Oler, Andrew J., Milner, Joshua D., and Ombrello, Michael J.
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- 2024
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24. Artificial Intelligence Large Language Models Address Anterior Cruciate Ligament Reconstruction: Superior Clarity and Completeness by Gemini Compared With ChatGPT-4 in Response to American Academy of Orthopaedic Surgeons Clinical Practice Guidelines
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Quinn, Matthew, Milner, John D., Schmitt, Phillip, Morrissey, Patrick, Lemme, Nicholas, Marcaccio, Stephen, DeFroda, Steven, Tabaddor, Ramin, and Owens, Brett D.
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- 2024
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25. PLCG2-associated immune dysregulation (PLAID) comprises broad and distinct clinical presentations related to functional classes of genetic variants
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Abbott, Jordan K., Aldave Becerra, Juan Carlos, Allenspach, Eric J., Assing, Kristian, Atkinson, T. Prescott, Bargir, Umair A., Baxter, Sarah K., Bergerson, Jenna R.E., Bista, Ranjan, Blanche, Stephane, Buckley, Lenore M., Butte, Manish, Carcamo, Benjamin, Chandrakala, Shanmukhaiah, Chen, Karin, Chervinskiy, Sheva, Chinn, Ivan K., Chong, Hey J., Coffey, Kara E., Copland, Andrew P., Cowen, Edward W., Cros, Guilhem, De Bruycker, Jean Jacques, Teresa de la Morena, Maria, Ehlayel, Mohammed, Forbes Satter, Lisa R., Gelfand, Erwin W., Gilliaux, Olivier, Glover, Sara C., Gorman, Mark, Griffin, Thomas A., Grimbacher, Bodo, Gru, Alejandro A., Haddad, Elie, Hadjadj, Jerome, Hajjar, Joud, Hauck, Fabian, Hautala, Timo, Holland, Steven M., Hsieh, Elena W.Y., Hsu, Florence Ida, Jacquemin, Emmanuel, Jindal, Ankur Kumar, Kahn, Stacy A., Keller, Michael D., Kobayashi, Roger H., Krupski, Christa, Larkin, Allyson, Lawrence, Monica G., Madkaikar, Manisha, Malphettes, Marion, Martelius, Timi, Mehta, Mehek, Metcalfe, Dean D., Meyts, Isabelle, Nannapaneni, Naveen, Ocejo Vinyals, J. Gonzalo, Olivier, Kenneth, Ombrello, Amanda K., Orange, Jordan S., Rabinovitch, Nathan, Rauscher, Christine K., Redfern, Ann, Reynolds, Paul R., Rieux-Laucat, Frederic, Secord, Elizabeth, Seeborg, Filiz O., Seppänen, Mikko R.J., Sereti, Irini, Shin, Daniel S., Shin, Junghee J., Snapper, Scott B., Suri, Deepti, Tangcheewinsirikul, Sirikarn, Thatayatikom, Akaluck, Torgerson, Troy, Touzot, Fabien, Uzel, Gulbu, Varjosalo, Markku, Vasconcelos, Dewton F.P., von Bernuth, Horst, Walsh, Thomas, Walter, Jolan E., Ward, Brant R., Wittkowski, Helmut, Wysocki, Christian A., Baysac, Kathleen, Sun, Guangping, Nakano, Hiroto, Schmitz, Elizabeth G., Cruz, Anthony C., Fisher, Charles, Bailey, Alexis C., Mace, Emily, Milner, Joshua D., and Ombrello, Michael J.
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- 2024
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26. Epicutaneous Staphylococcus aureus induces IL-36 to enhance IgE production and ensuing allergic disease
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Patrick, Garrett J, Liu, Haiyun, Alphonse, Martin P, Dikeman, Dustin A, Youn, Christine, Otterson, Jack C, Wang, Yu, Ravipati, Advaitaa, Mazhar, Momina, Denny, George, Ortines, Roger V, Zhang, Emily, Miller, Robert J, Dillen, Carly A, Liu, Qi, Nolan, Sabrina J, Nguyen, Kristine, Marcello, LeeAnn, C., Danh, Wier, Eric M, Zhang, Yan, Caviness, Gary, Klimowicz, Alexander C, Mierz, Diane V, Fine, Jay S, Sun, Guangping, Goldbach-Mansky, Raphaela, Marusina, Alina I, Merleev, Alexander A, Maverakis, Emanual, Garza, Luis A, Milner, Joshua D, Gao, Peisong, Ramanujam, Meera, Raymond, Ernest L, Archer, Nathan K, and Miller, Lloyd S
- Subjects
Eczema / Atopic Dermatitis ,Infectious Diseases ,Food Allergies ,Lung ,Emerging Infectious Diseases ,Aetiology ,2.2 Factors relating to the physical environment ,2.1 Biological and endogenous factors ,Inflammatory and immune system ,Skin ,Animals ,Cell Differentiation ,Dermatitis ,Atopic ,Humans ,Immunoglobulin Class Switching ,Immunoglobulin E ,Interleukin-1 ,Interleukin-4 ,Keratinocytes ,Mice ,Mice ,Knockout ,Plasma Cells ,Staphylococcus aureus ,Allergy ,Cytokines ,Immunology ,Inflammation ,Medical and Health Sciences - Abstract
IgE induced by type 2 immune responses in atopic dermatitis is implicated in the progression of atopic dermatitis to other allergic diseases, including food allergies, allergic rhinitis, and asthma. However, the keratinocyte-derived signals that promote IgE and ensuing allergic diseases remain unclear. Herein, in a mouse model of atopic dermatitis-like skin inflammation induced by epicutaneous Staphylococcus aureus exposure, keratinocyte release of IL‑36α along with IL-4 triggered B cell IgE class-switching, plasma cell differentiation, and increased serum IgE levels-all of which were abrogated in IL-36R-deficient mice or anti-IL‑36R-blocking antibody-treated mice. Moreover, skin allergen sensitization during S. aureus epicutaneous exposure-induced IL-36 responses was required for the development of allergen-specific lung inflammation. In translating these findings, elevated IL‑36 cytokines in human atopic dermatitis skin and in IL‑36 receptor antagonist-deficiency patients coincided with increased serum IgE levels. Collectively, keratinocyte-initiated IL‑36 responses represent a key mechanism and potential therapeutic target against allergic diseases.
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- 2021
27. Ventricular function and tissue characterization by cardiac magnetic resonance imaging following hospitalization for multisystem inflammatory syndrome in children: a prospective study
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DiLorenzo, Michael P., Farooqi, Kanwal M., Shah, Amee M., Channing, Alexandra, Harrington, Jamie K., Connors, Thomas J., Martirosyan, Karen, Krishnan, Usha S., Ferris, Anne, Weller, Rachel J., Farber, Donna L., Milner, Joshua D., Gorelik, Mark, Rosenzweig, Erika B., and Anderson, Brett R.
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- 2023
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28. Decisional regret, symptom burden, and quality of life following transoral robotic surgery for oropharyngeal cancer
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Kwon, Jamie Jae Young, Liu, Alice Q., Milner, Thomas D., and Prisman, Eitan
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- 2023
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29. ERBIN and phosphoglucomutase 3 deficiency
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Milner, Joshua D
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- 2023
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30. Multiplexed Functional Assessment of Genetic Variants in CARD11
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Meitlis, Iana, Allenspach, Eric J, Bauman, Bradly M, Phan, Isabelle Q, Dabbah, Gina, Schmitt, Erica G, Camp, Nathan D, Torgerson, Troy R, Nickerson, Deborah A, Bamshad, Michael J, Hagin, David, Luthers, Christopher R, Stinson, Jeffrey R, Gray, Jessica, Lundgren, Ingrid, Church, Joseph A, Butte, Manish J, Jordan, Mike B, Aceves, Seema S, Schwartz, Daniella M, Milner, Joshua D, Schuval, Susan, Skoda-Smith, Suzanne, Cooper, Megan A, Starita, Lea M, Rawlings, David J, Snow, Andrew L, and James, Richard G
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Biological Sciences ,Biomedical and Clinical Sciences ,Genetics ,Genetic Testing ,Human Genome ,Biotechnology ,Good Health and Well Being ,Adenine ,B-Cell CLL-Lymphoma 10 Protein ,B-Lymphocytes ,CARD Signaling Adaptor Proteins ,Cell Line ,Diploidy ,Exons ,Genes ,Dominant ,Genetic Variation ,Guanylate Cyclase ,Humans ,Immunologic Deficiency Syndromes ,Jurkat Cells ,Lymphoma ,NF-kappa B p50 Subunit ,Piperidines ,Polymorphism ,Single Nucleotide ,Primary Immunodeficiency Diseases ,Sensitivity and Specificity ,B cells ,CARD11 ,gene editing ,immune dysregulation ,lymphoma ,primary immune deficiency ,saturation genome editing ,variant interpretation ,Medical and Health Sciences ,Genetics & Heredity ,Biological sciences ,Biomedical and clinical sciences ,Health sciences - Abstract
Genetic testing has increased the number of variants identified in disease genes, but the diagnostic utility is limited by lack of understanding variant function. CARD11 encodes an adaptor protein that expresses dominant-negative and gain-of-function variants associated with distinct immunodeficiencies. Here, we used a "cloning-free" saturation genome editing approach in a diploid cell line to simultaneously score 2,542 variants for decreased or increased function in the region of CARD11 associated with immunodeficiency. We also described an exon-skipping mechanism for CARD11 dominant-negative activity. The classification of reported clinical variants was sensitive (94.6%) and specific (88.9%), which rendered the data immediately useful for interpretation of seven coding and splicing variants implicated in immunodeficiency found in our clinic. This approach is generalizable for variant interpretation in many other clinically actionable genes, in any relevant cell type.
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- 2020
31. Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome.
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Béziat, Vivien, Tavernier, Simon J, Chen, Yin-Huai, Ma, Cindy S, Materna, Marie, Laurence, Arian, Staal, Jens, Aschenbrenner, Dominik, Roels, Lisa, Worley, Lisa, Claes, Kathleen, Gartner, Lisa, Kohn, Lisa A, De Bruyne, Marieke, Schmitz-Abe, Klaus, Charbonnier, Louis-Marie, Keles, Sevgi, Nammour, Justine, Vladikine, Natasha, Maglorius Renkilaraj, Majistor Raj Luxman, Seeleuthner, Yoann, Migaud, Mélanie, Rosain, Jérémie, Jeljeli, Mohamed, Boisson, Bertrand, Van Braeckel, Eva, Rosenfeld, Jill A, Dai, Hongzheng, Burrage, Lindsay C, Murdock, David R, Lambrecht, Bart N, Avettand-Fenoel, Véronique, Vogel, Tiphanie P, Undiagnosed Diseases Network, Esther, Charles R, Haskologlu, Sule, Dogu, Figen, Ciznar, Peter, Boutboul, David, Ouachée-Chardin, Marie, Amourette, Jean, Lebras, Marie-Noëlle, Gauvain, Clément, Tcherakian, Colas, Ikinciogullari, Aydan, Beyaert, Rudi, Abel, Laurent, Milner, Joshua D, Grimbacher, Bodo, Couderc, Louis-Jean, Butte, Manish J, Freeman, Alexandra F, Catherinot, Émilie, Fieschi, Claire, Chatila, Talal A, Tangye, Stuart G, Uhlig, Holm H, Haerynck, Filomeen, Casanova, Jean-Laurent, and Puel, Anne
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Undiagnosed Diseases Network ,Th2 Cells ,Cells ,Cultured ,Cell Membrane ,Fibroblasts ,Humans ,C-Reactive Protein ,Cytokines ,Pedigree ,Genetics ,Population ,Up-Regulation ,Kinetics ,Genes ,Dominant ,Phenotype ,Mutation ,Alleles ,Models ,Biological ,Adolescent ,Middle Aged ,Child ,Female ,Male ,Cytokine Receptor gp130 ,Young Adult ,HEK293 Cells ,Job Syndrome ,Loss of Function Mutation ,Cells ,Cultured ,Genetics ,Population ,Genes ,Dominant ,Models ,Biological ,Medical and Health Sciences ,Immunology - Abstract
Autosomal dominant hyper-IgE syndrome (AD-HIES) is typically caused by dominant-negative (DN) STAT3 mutations. Patients suffer from cold staphylococcal lesions and mucocutaneous candidiasis, severe allergy, and skeletal abnormalities. We report 12 patients from 8 unrelated kindreds with AD-HIES due to DN IL6ST mutations. We identified seven different truncating mutations, one of which was recurrent. The mutant alleles encode GP130 receptors bearing the transmembrane domain but lacking both the recycling motif and all four STAT3-recruiting tyrosine residues. Upon overexpression, the mutant proteins accumulate at the cell surface and are loss of function and DN for cellular responses to IL-6, IL-11, LIF, and OSM. Moreover, the patients' heterozygous leukocytes and fibroblasts respond poorly to IL-6 and IL-11. Consistently, patients with STAT3 and IL6ST mutations display infectious and allergic manifestations of IL-6R deficiency, and some of the skeletal abnormalities of IL-11R deficiency. DN STAT3 and IL6ST mutations thus appear to underlie clinical phenocopies through impairment of the IL-6 and IL-11 response pathways.
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- 2020
32. Genetically defined individual reference ranges for tryptase limit unnecessary procedures and unmask myeloid neoplasms
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Chovanec, Jack, Tunc, Ilker, Hughes, Jason, Halstead, Joseph, Mateja, Allyson, Liu, Yihui, O’Connell, Michael P., Kim, Jiwon, Park, Young Hwan, Wang, Qinlu, Le, Quang, Pirooznia, Mehdi, Trivedi, Neil N., Bai, Yun, Yin, Yuzhi, Hsu, Amy P., McElwee, Joshua, Lassiter, Sheryce, Nelson, Celeste, Bandoh, Judy, DiMaggio, Thomas, Šelb, Julij, Rijavec, Matija, Carter, Melody C., Komarow, Hirsh D., Sabato, Vito, Steinberg, Joshua, Hafer, Kurt M., Feuille, Elizabeth, Hourigan, Christopher S., Lack, Justin, Khoury, Paneez, Maric, Irina, Zanotti, Roberta, Bonadonna, Patrizia, Schwartz, Lawrence B., Milner, Joshua D., Glover, Sarah C., Ebo, Didier G., Korošec, Peter, Caughey, George H., Brittain, Erica H., Busby, Ben, Metcalfe, Dean D., and Lyons, Jonathan J.
- Published
- 2023
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33. Osteoarthritis in the Upper Extremity
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Hartnett, Davis A., Milner, John D., and DeFroda, Steven F.
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- 2023
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34. Monogenic early-onset lymphoproliferation and autoimmunity: Natural history of STAT3 gain-of-function syndrome
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Aleshkevich, Svetlana, Allende, Luis M., Atkinson, T. Prescott, Atschekzei, Faranaz, Aydemir, Sezin, Aygunes, Utku, Barlogis, Vincent, Baumann, Ulrich, Belko, John, Bezrodnik, Liliana, Biebl, Ariane, Broderick, Lori, Bunin, Nancy J., Caldirola, Maria Soledad, Castelle, Martin, Celmeli, Fatih, Charbonnier, Louis-Marie, Chatila, Talal A., Chellapandian, Deepak, Cokugras, Haluk, Conlon, Niall, Cox, Fionnuala, Crickx, Etienne, Dalgic, Buket, ASH Dalm, Virgil, Danielian, Silvia, Dominguez-Pinilla, Nerea, Dujovny, Tal, Ebbo, Mikael, Eken, Ahmet, Esty, Brittany, Fabre, Alexandre, Fischer, Alain, Hannibal, Mark, Huppert, Laura, Ikeda, Marc D., Jolles, Stephen, Jolly, Kent W., Jones, Neil, Kanariou, Maria, Karakoc-Aydiner, Elif, Karamantziani, Theoni, Kelaidi, Charikleia, Keogan, Mary, Pac Kisaarslan, Ayşenur, Kiykim, Ayca, Klocperk, Adam, Kotsonis, Kosmas, Kuzmenko, Natalia, Leroy, Sylvie, Lianou, Dimitra, Longhurst, Hilary, Lorenz, Myriam Ricarda, Maffucci, Patrick, Manson, Ania, Marchal, Sarah, Malphettes, Marion, Marega, Lia Furlaneto, Mauracher, Andrea A., Meesilpavikai, Kornvalee, Miller, Holly, Mombourquette, Joy, Morgan, Noel G., Mukhina, Anna, Nathalie, Aladjidi, Nelken, Brigitte, Nolan, David, Norlin, Anna-Carin, Oleastro, Matias, Ozcan, Alper, Pasquet, Marlene, Pegler, José Roberto, Picard, Capucine, Polychronopoulou, Sophia, Quartier, Pierre, Quesada, Juan Francisco, Ramakers, Jan, Randall, Katrina L., Rao, V. Koneti, Remiker, Allison, Resin, Geraldine, Richmond, Peter, Rieux-Laucat, Frederic, Rodina, Yulia, Rohrlich, Pierre, Sachs, Johnathan, Sakovich, Inga, Santarlas, Christopher, Sari, Sinan, Sawicki, Gregory, Schauer, Uwe, Scheffler Mendoza, Selma C., Schvetz, Oksana, Schmidt, Reinhold Ernst, Schwarz, Klaus, Sediva, Anna, Sinclair, Kyle, Slatter, Mary, Sleasman, John, Stergiou, Katerina, Suratannon, Narissara, Tanita, Kay, Thompson, Grace, Travis, Stephen, Trojan, Timothy, Tsinti, Maria, Unal, Ekrem, Urdinez, Luciano, Vazquez-Gomez, Felisa, Villa, Mariana, Weinrich, Michael, Weiss, Mitchell J., Wright, Benjamin, Yilmaz, Ebru, Zachova, Radana, Zhang, Yu, Leiding, Jennifer W., Vogel, Tiphanie P., Santarlas, Valentine G.J., Mhaskar, Rahul, Smith, Madison R., Carisey, Alexandre, Vargas-Hernández, Alexander, Silva-Carmona, Manuel, Heeg, Maximilian, Rensing-Ehl, Anne, Neven, Bénédicte, Hadjadj, Jérôme, Hambleton, Sophie, Ronan Leahy, Timothy, Cunningham-Rundles, Charlotte, Dutmer, Cullen M., Sharapova, Svetlana O., Taskinen, Mervi, Chua, Ignatius, Hague, Rosie, Klemann, Christian, Kostyuchenko, Larysa, Morio, Tomohiro, Thatayatikom, Akaluck, Ozen, Ahmet, Scherbina, Anna, Bauer, Cindy S., Flanagan, Sarah E., Gambineri, Eleonora, Giovannini-Chami, Lisa, Heimall, Jennifer, Sullivan, Kathleen E., Allenspach, Eric, Romberg, Neil, Deane, Sean G., Prince, Benjamin T., Rose, Melissa J., Bohnsack, John, Mousallem, Talal, Jesudas, Rohith, Santos Vilela, Maria Marluce Dos, O’Sullivan, Michael, Pachlopnik Schmid, Jana, Průhová, Štěpánka, Rees, Matthew, Su, Helen, Bahna, Sami, Baris, Safa, Bartnikas, Lisa M., Chang Berger, Amy, Briggs, Tracy A., Brothers, Shannon, Bundy, Vanessa, Chan, Alice Y., Chandrakasan, Shanmuganathan, Christiansen, Mette, Cole, Theresa, Cook, Matthew C., Desai, Mukesh M., Fischer, Ute, Fulcher, David A., Gallo, Silvanna, Gauthier, Amelie, Gennery, Andrew R., Gonçalo Marques, José, Gottrand, Frédéric, Grimbacher, Bodo, Grunebaum, Eyal, Haapaniemi, Emma, Hämäläinen, Sari, Heiskanen, Kaarina, Heiskanen-Kosma, Tarja, Hoffman, Hal M., Gonzalez-Granado, Luis Ignacio, Guerrerio, Anthony L., Kainulainen, Leena, Kumar, Ashish, Lawrence, Monica G., Levin, Carina, Martelius, Timi, Neth, Olaf, Olbrich, Peter, Palma, Alejandro, Patel, Niraj C., Pozos, Tamara, Preece, Kahn, Lugo Reyes, Saúl Oswaldo, Russell, Mark A., Schejter, Yael, Seroogy, Christine, Sinclair, Jan, Skevofilax, Effie, Suan, Daniel, Suez, Daniel, Szabolcs, Paul, Velasco, Helena, Warnatz, Klaus, Walkovich, Kelly, Worth, Austen, Seppänen, Mikko R.J., Torgerson, Troy R., Sogkas, Georgios, Ehl, Stephan, Tangye, Stuart G., Cooper, Megan A., Milner, Joshua D., and Forbes Satter, Lisa R.
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- 2023
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35. Publisher Correction: Dynamic chromatin accessibility licenses STAT5- and STAT6-dependent innate-like function of TH9 cells to promote allergic inflammation
- Author
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Son, Aran, Meylan, Francoise, Gomez-Rodriguez, Julio, Kaul, Zenia, Sylvester, McKella, Falduto, Guido H., Vazquez, Estefania, Haque, Tamara, Kitakule, Moses M., Wang, Chujun, Manthiram, Kalpana, Qi, Chen-Feng, Cheng, Jun, Gurram, Rama K., Zhu, Jinfang, Schwartzberg, Pamela, Milner, Joshua D., Frischmeyer-Guerrerio, Pamela A., and Schwartz, Daniella M.
- Published
- 2023
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- View/download PDF
36. Validation of the novel Deep Reality Viewer (DRV) 3D digital stereo viewer in otology surgery
- Author
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Milner, Thomas D., Denton, Oliver, Moen, Christy M., and Iyer, Arunachalam
- Published
- 2022
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37. Orthopedic manifestations of child abuse
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Milner, John D., Hartnett, Davis A., DeFroda, Steven F., Slingsby, Brett A., Silber, Zachary S., Blackburn, Amy Z., Daniels, Alan H., and Cruz, Jr, Aristides I.
- Published
- 2022
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38. Introduction to clinical research
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Milner, John D., primary, Hartnett, Davis A., additional, and Testa, Edward J., additional
- Published
- 2023
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39. List of contributors
- Author
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Abboud, Joseph, primary, Akhnoukh, Kyrillos M., additional, Alexandrov, Alexander, additional, Aljabi, Anas, additional, Arce, Giuliana Colombari, additional, Arias, Daniel, additional, Avendaño Capriles, Camilo Andres, additional, Azarpey, Ali, additional, Bach, Vu N., additional, Baez, Catalina, additional, Belzie, Alissa, additional, Best, Matthew J., additional, Beyer, Julia, additional, Bishop, Meghan E., additional, Bogdan, Paulina, additional, Bouck, Trevor, additional, Boyd, Brandon, additional, Brown, Bryanna, additional, Campbell, Michael P., additional, Capotosto, Salvatore, additional, Cardiel Castro, Luis Felipe, additional, Carlos, Noel Bien Tan, additional, Carrasco, Felipe, additional, Cedeno-Serna, Juan, additional, Chang, Jaewon, additional, Chang, Edward S., additional, Chen, Christine, additional, Clark, Philip, additional, Cloud, Geoffrey, additional, Coco, Laura, additional, Cohen, Brian H., additional, Conway, Charles, additional, Cortina, Carolina Campuzano, additional, Cox, Ryan M., additional, Coyner, Katherine, additional, Crasto, Cameron, additional, Cury Perea, Ines Yaritza, additional, Del Re, Andrew, additional, DePhillipo, Nicholas N., additional, Diamond, Keith Brett, additional, DiCosmo, Michael B., additional, Dixit, Meehir, additional, Dollar, Christina M., additional, Donovan, Luke, additional, Duffield, Tyler C., additional, Elattar, Osama, additional, Elbin, R.J., additional, Elphingstone, Joseph, additional, Emara, Ahmed, additional, Erez, Orry, additional, Escobar, María Fernanda, additional, Ettenhofer, Mark L., additional, Fackler, Nathan P., additional, Fallon, Ryan T., additional, Fayed, Aly M., additional, Ferlic, Mason, additional, Fernández-Cásseres, María A., additional, Fertala, Andrzej, additional, Figueras, Jorge H., additional, Freedman, Kevin B., additional, Gallun, Frederick J., additional, Garcia, John Paul, additional, Ginalis, Elizabeth E., additional, Grawe, Brian M., additional, Gruffi, Lauren, additional, Guettler, Joseph, additional, Harrison, Laura, additional, Hart, Joe, additional, Hartnett, Davis A., additional, Henriquez Abramuk, Maria F., additional, Hevesi, Mario, additional, Holodinsky, Jessalyn K., additional, Horn, Andrew, additional, Ibrahim, Zainab, additional, Idrizi, Adem, additional, Ignacio, Gian Christian T., additional, Imankhan, Mahshid, additional, Imas, Alexander S., additional, Jain, Shreya, additional, Jami, Meghana, additional, Jan, Kyleen, additional, Jason Wong, Che Hang, additional, Jawa, Andrew, additional, Jimenez Mosquea, Thelma R., additional, Joshi, Pinak, additional, Kamada, Sneha, additional, Kang, Kevin K., additional, Kassam, Hafiz F., additional, Khan, Nabil Z., additional, King, James A., additional, Klifto, Christopher, additional, Knebels, Rebecca, additional, Koch, Christopher, additional, Kossman, Melissa K., additional, Kothari, Ezan, additional, Kremen, Thomas J., additional, Krivicich, Laura M., additional, Kucera, Kristen L., additional, Kuenze, Christopher M., additional, Kutschke, Michael, additional, Lacouture, Salomon Abuchaibe, additional, Lacouture Cardenas, Natalia Andrea, additional, Lam, Aaron, additional, Langner Salinas, Fabiola, additional, Lepley, Adam S., additional, Libreros-Peña, Laura, additional, Liu, Jonathan, additional, Liu, Sean, additional, Lohre, Ryan, additional, Luthringer, Tyler A., additional, Magruder, Matthew, additional, Maheshwer, Bhargavi, additional, Manzur-Pineda, Karen, additional, Marcaccio, Stephen E., additional, Martínez-Robles, Karen J., additional, Mercado Rueda, Anette Paulin, additional, Mescher, Patrick, additional, Mihas, Alexander, additional, Mikula, Jacob D., additional, Miller, Jacob D., additional, Milner, John D., additional, Moattari, Kevin, additional, Mowery, Alia J., additional, Murthi, Anand M., additional, Musharbash, Farah N., additional, Nassis, Electra, additional, Ng, Mitchell K., additional, Nho, Shane J., additional, Norte, Grant E., additional, Nwosu, Chinemerem, additional, Ocoro Vallecilla, Arnold, additional, Orellana, Manuel A., additional, Oshobu, Ibukunolowa, additional, Padilla, José Carlos, additional, Paracha, Noorulain, additional, Patel, Sneha, additional, Paul, Ryan W., additional, Pereira Zapata, Paula Andrea, additional, Peña-Zárate, Evelyn E., additional, Philips, Alexander P., additional, Pill, Stephan G., additional, Piuzzi, Nicolas, additional, Quan, Theodore, additional, Quinn, Matthew, additional, Quinoa, Travis R., additional, Ramtin, Sina, additional, Razi, Afshin E., additional, Rondon, Alexander J., additional, Russi-Pulgar, Daniela, additional, Saad, Maarouf, additional, Sabharwal, Samir, additional, Sanchez, Giovanni, additional, Sanders, James, additional, Sanko, Cassandra, additional, Shah, Armaan, additional, Shaw, Jesse, additional, Sheth, Bhavya K., additional, Sheth, Divya K., additional, Shi, Brendan Y., additional, Singh, Rohanit, additional, Sinkler, Margaret A., additional, Sohn, David H., additional, Sonnier, John Hayden, additional, Srikumaran, Uma, additional, Sriram, Varun, additional, Stoll, Kurt Edward, additional, Strassburg, Alyssa, additional, Sullivan, Camille, additional, Suresh, Krishna V., additional, Suresh, Sukrit, additional, Tamayo-Torres, Claudia Sofía, additional, Testa, Edward J., additional, Thamer, Semran B., additional, Thomson, Cameron G., additional, Titter, Julie, additional, Torrez, Timothy, additional, Toy, Kristin, additional, Tranovich, Meaghan, additional, Vakharia, Rushabh M., additional, Valentino, Nicolás, additional, Valenzuela-Vallejo, Laura, additional, van Eck, Carola F., additional, Varghese, Priscilla, additional, Varzhapetyan, Vahe, additional, Vaughan, Alayna K., additional, Vingan, Perri, additional, Vippa, Tarun K., additional, Williams, Kevin, additional, Williamson, Tyler, additional, Womble, Melissa, additional, Wright, Melissa A., additional, Wu, Shannon Y., additional, Xylas, Diamantis, additional, Yañez-Sarmiento, Anamaria, additional, and Ziauddin, Lubna, additional
- Published
- 2023
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40. Surgical Treatment of Patellar Tendinopathy/Osgood–Schlatter’s Disease
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Shubert, Daniel, primary, Hartnett, Davis A., additional, Milner, John D., additional, and DeFroda, Steven F., additional
- Published
- 2023
- Full Text
- View/download PDF
41. Elevated IgE from attenuated CARD11 signaling: lessons from atopic mice and humans
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Pomerantz, Joel L, Milner, Joshua D, and Snow, Andrew L
- Published
- 2022
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42. Ex vivo effect of JAK inhibition on JAK-STAT1 pathway hyperactivation in patients with dominant-negative STAT3 mutations
- Author
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Lobo, Pilar Blanco, Guisado-Hernández, Paloma, Villaoslada, Isabel, de Felipe, Beatriz, Carreras, Carmen, Rodriguez, Hector, Carazo-Gallego, Begoña, Méndez-Echevarria, Ana, Lucena, José Manuel, Aljaro, Pilar Ortiz, Castro, María José, Noguera-Uclés, José Francisco, Milner, Joshua D., McCann, Katelyn, Zimmerman, Ofer, Freeman, Alexandra F., Lionakis, Michail S., Holland, Steven M., Neth, Olaf, and Olbrich, Peter
- Published
- 2022
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- View/download PDF
43. Atopy as Immune Dysregulation: Offender Genes and Targets
- Author
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Vaseghi-Shanjani, Maryam, Snow, Andrew L., Margolis, David J., Latrous, Meriem, Milner, Joshua D., Turvey, Stuart E., and Biggs, Catherine M.
- Published
- 2022
- Full Text
- View/download PDF
44. Mechanisms of Respiratory Failure
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Greenough, Anne, Milner, Anthony D., Donn, Steven M., editor, Mammel, Mark C., editor, and van Kaam, Anton H.L.C., editor
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- 2022
- Full Text
- View/download PDF
45. Tissue Hypoxia
- Author
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Greenough, Anne, Milner, Anthony D., Donn, Steven M., editor, Mammel, Mark C., editor, and van Kaam, Anton H.L.C., editor
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- 2022
- Full Text
- View/download PDF
46. The Weekend Warrior: Common Shoulder and Elbow Injuries in the Recreational Athlete
- Author
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Hartnett, Davis A., Milner, John D., and DeFroda, Steven F.
- Published
- 2022
- Full Text
- View/download PDF
47. Expansion of the Human Phenotype Ontology (HPO) knowledge base and resources
- Author
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Köhler, Sebastian, Carmody, Leigh, Vasilevsky, Nicole, Jacobsen, Julius OB, Danis, Daniel, Gourdine, Jean-Philippe, Gargano, Michael, Harris, Nomi L, Matentzoglu, Nicolas, McMurry, Julie A, Osumi-Sutherland, David, Cipriani, Valentina, Balhoff, James P, Conlin, Tom, Blau, Hannah, Baynam, Gareth, Palmer, Richard, Gratian, Dylan, Dawkins, Hugh, Segal, Michael, Jansen, Anna C, Muaz, Ahmed, Chang, Willie H, Bergerson, Jenna, Laulederkind, Stanley JF, Yüksel, Zafer, Beltran, Sergi, Freeman, Alexandra F, Sergouniotis, Panagiotis I, Durkin, Daniel, Storm, Andrea L, Hanauer, Marc, Brudno, Michael, Bello, Susan M, Sincan, Murat, Rageth, Kayli, Wheeler, Matthew T, Oegema, Renske, Lourghi, Halima, Della Rocca, Maria G, Thompson, Rachel, Castellanos, Francisco, Priest, James, Cunningham-Rundles, Charlotte, Hegde, Ayushi, Lovering, Ruth C, Hajek, Catherine, Olry, Annie, Notarangelo, Luigi, Similuk, Morgan, Zhang, Xingmin A, Gómez-Andrés, David, Lochmüller, Hanns, Dollfus, Hélène, Rosenzweig, Sergio, Marwaha, Shruti, Rath, Ana, Sullivan, Kathleen, Smith, Cynthia, Milner, Joshua D, Leroux, Dorothée, Boerkoel, Cornelius F, Klion, Amy, Carter, Melody C, Groza, Tudor, Smedley, Damian, Haendel, Melissa A, Mungall, Chris, and Robinson, Peter N
- Subjects
Biological Sciences ,Bioinformatics and Computational Biology ,Genetics ,Rare Diseases ,Human Genome ,Networking and Information Technology R&D (NITRD) ,Generic health relevance ,Good Health and Well Being ,Biological Ontologies ,Computational Biology ,Congenital Abnormalities ,Databases ,Genetic ,Genetic Predisposition to Disease ,Genetic Variation ,Humans ,Internet ,Knowledge Bases ,Phenotype ,Whole Genome Sequencing ,Environmental Sciences ,Information and Computing Sciences ,Developmental Biology ,Biological sciences ,Chemical sciences ,Environmental sciences - Abstract
The Human Phenotype Ontology (HPO)-a standardized vocabulary of phenotypic abnormalities associated with 7000+ diseases-is used by thousands of researchers, clinicians, informaticians and electronic health record systems around the world. Its detailed descriptions of clinical abnormalities and computable disease definitions have made HPO the de facto standard for deep phenotyping in the field of rare disease. The HPO's interoperability with other ontologies has enabled it to be used to improve diagnostic accuracy by incorporating model organism data. It also plays a key role in the popular Exomiser tool, which identifies potential disease-causing variants from whole-exome or whole-genome sequencing data. Since the HPO was first introduced in 2008, its users have become both more numerous and more diverse. To meet these emerging needs, the project has added new content, language translations, mappings and computational tooling, as well as integrations with external community data. The HPO continues to collaborate with clinical adopters to improve specific areas of the ontology and extend standardized disease descriptions. The newly redesigned HPO website (www.human-phenotype-ontology.org) simplifies browsing terms and exploring clinical features, diseases, and human genes.
- Published
- 2019
48. Clonally expanded γδ T cells protect against Staphylococcus aureus skin reinfection
- Author
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Dillen, Carly A, Pinsker, Bret L, Marusina, Alina I, Merleev, Alexander A, Farber, Orly N, Liu, Haiyun, Archer, Nathan K, Lee, Da B, Wang, Yu, Ortines, Roger V, Lee, Steven K, Marchitto, Mark C, Cai, Shuting S, Ashbaugh, Alyssa G, May, Larissa S, Holland, Steven M, Freeman, Alexandra F, Miller, Loren G, Yeaman, Michael R, Simon, Scott I, Milner, Joshua D, Maverakis, Emanual, and Miller, Lloyd S
- Subjects
Biochemistry and Cell Biology ,Biomedical and Clinical Sciences ,Biological Sciences ,Microbiology ,Clinical Sciences ,Immunology ,Infectious Diseases ,Emerging Infectious Diseases ,Biodefense ,1.1 Normal biological development and functioning ,Infection ,Inflammatory and immune system ,Animals ,Female ,Gene Rearrangement ,Interferon-gamma ,Interleukin-17 ,Interleukin-1beta ,Interleukins ,Intraepithelial Lymphocytes ,Male ,Mice ,Mice ,Inbred C57BL ,Neutrophil Infiltration ,Neutrophils ,Receptors ,Antigen ,T-Cell ,gamma-delta ,Sequence Analysis ,RNA ,Signal Transduction ,Skin Diseases ,Bacterial ,Staphylococcal Infections ,Staphylococcus aureus ,Tumor Necrosis Factor-alpha ,Interleukin-22 ,Adaptive immunity ,Bacterial infections ,Infectious disease ,Skin ,Medical and Health Sciences ,Biological sciences ,Biomedical and clinical sciences ,Health sciences - Abstract
The mechanisms that mediate durable protection against Staphylococcus aureus skin reinfections are unclear, as recurrences are common despite high antibody titers and memory T cells. Here, we developed a mouse model of S. aureus skin reinfection to investigate protective memory responses. In contrast with WT mice, IL-1β-deficient mice exhibited poor neutrophil recruitment and bacterial clearance during primary infection that was rescued during secondary S. aureus challenge. The γδ T cells from skin-draining LNs utilized compensatory T cell-intrinsic TLR2/MyD88 signaling to mediate rescue by trafficking and producing TNF and IFN-γ, which restored neutrophil recruitment and promoted bacterial clearance. RNA-sequencing (RNA-seq) of the LNs revealed a clonotypic S. aureus-induced γδ T cell expansion with a complementarity-determining region 3 (CDR3) aa sequence identical to that of invariant Vγ5+ dendritic epidermal T cells. However, this T cell receptor γ (TRG) aa sequence of the dominant CDR3 sequence was generated from multiple gene rearrangements of TRGV5 and TRGV6, indicating clonotypic expansion. TNF- and IFN-γ-producing γδ T cells were also expanded in peripheral blood of IRAK4-deficient humans no longer predisposed to S. aureus skin infections. Thus, clonally expanded γδ T cells represent a mechanism for long-lasting immunity against recurrent S. aureus skin infections.
- Published
- 2018
49. Clinical relevance of inherited genetic differences in human tryptases: Hereditary alpha-tryptasemia and beyond
- Author
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Glover, Sarah C., Carter, Melody C., Korošec, Peter, Bonadonna, Patrizia, Schwartz, Lawrence B., Milner, Joshua D., Caughey, George H., Metcalfe, Dean D., and Lyons, Jonathan J.
- Published
- 2021
- Full Text
- View/download PDF
50. Small intestinal immunopathology and GI-associated antibody formation in hereditary alpha-tryptasemia
- Author
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Konnikova, Liza, Robinson, Tanya O., Owings, Anna H., Shirley, James F., Davis, Elisabeth, Tang, Ying, Wall, Sarah, Li, Jian, Hasan, Mohammad H., Gharaibeh, Raad Z., Mendoza Alvarez, Lybil B., Ryan, Lisa K., Doty, Andria, Chovanec, Jack F., O’Connell, Michael P., Grunes, Dianne E., Daley, William P., Mayer, Emeran, Chang, Lin, Liu, Julia, Snapper, Scott B., Milner, Joshua D., Glover, Sarah C., and Lyons, Jonathan J.
- Published
- 2021
- Full Text
- View/download PDF
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