1. Distribution of lithostathine in the mouse lemur brain with aging and Alzheimer's-like pathology
- Author
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Laurent Givalois, Nadine Mestre-Francés, Jean-Michel Verdier, Stéphane Marchal, Mécanismes moléculaires dans les démences neurodégénératives (MMDN), Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Marchal, Stéphane, Université Montpellier 2 - Sciences et Techniques (UM2)-École pratique des hautes études (EPHE), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)
- Subjects
Pathology ,medicine.medical_specialty ,Aging ,Microcebus murinus ,lemur ,Hippocampus ,Hippocampal formation ,Corpus callosum ,Neuroprotection ,03 medical and health sciences ,MESH: Brain ,0302 clinical medicine ,Alzheimer Disease ,medicine ,Animals ,Tissue Distribution ,lithostathine ,MESH: Aging ,MESH: Animals ,[SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,MESH: Tissue Distribution ,EXTL3 ,MESH: Lithostathine ,030304 developmental biology ,0303 health sciences ,biology ,General Neuroscience ,Lithostathine ,Neurodegeneration ,Brain ,biology.organism_classification ,medicine.disease ,medicine.anatomical_structure ,beta-amyloid deposit ,Neuroglia ,[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,Neurology (clinical) ,MESH: Cheirogaleidae ,Geriatrics and Gerontology ,Cheirogaleidae ,030217 neurology & neurosurgery ,Reg1 ,MESH: Alzheimer Disease ,Developmental Biology - Abstract
31 pages; International audience; We analyzed the cellular distribution of the pancreatic inflammatory protein lithostathine and its receptor EXTL3 in the brain of the lemurian primate Microcebus murinus which develops amyloid deposits along with aging. In adult animals (2-4.5 years old), lithostathine and EXTL3 immunoreactivities were largely distributed in the whole brain, and more intensively in almost all cortical layers and hippocampal formation. Lithostathine was observed in the perikarya and neurites of cortical neurons but also in glial cells in the border of the ventricle and the corpus callosum. In healthy aged animals (8-13 years old), highest densities of lithostathine-containing cells were observed, mainly in occipital and parietal cortex. In aged animals with Aβ deposits, the increase in lithostathine immunoreactivity was lower as compared with aged animals. Noteworthy, lithostathine-immunopositive cells did almost never colocalize with Aβ plaques. In conclusion, lithostathine immunoreactivity in adult Microcebus murinus appeared ubiquitous and particularly in visual, sensorial, and cognitive brain areas. Immunoreactivity increased with aging and appeared markedly affected in neuropathological conditions. Its possible neuroprotection or neurodegeneration role in Alzheimer pathology deserves therefore to be investigated.
- Published
- 2012