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2 results on '"MESH: Hydra"'

1. Spontaneously occurring tumors in different wild-derived strains of hydra

Author

Boutry, Justine, Buysse, Marie, Tissot, Sophie, Cazevielle, Chantal, Hamede, Rodrigo, Dujon, Antoine, Ujvari, Beata, Giraudeau, Mathieu, Klimovich, Alexander, Thomas, Frédéric, Tökölyi, Jácint, Centre de Recherches Ecologiques et Evolutives sur le Cancer (MIVEGEC-CREEC), Processus Écologiques et Évolutifs au sein des Communautés (PEEC), Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM)-Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM), Institut des Neurosciences de Montpellier (INM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Deakin University [Waurn Ponds], LIttoral ENvironnement et Sociétés (LIENSs), La Rochelle Université (ULR)-Centre National de la Recherche Scientifique (CNRS), Christian-Albrechts University of Kiel, University of Debrecen Egyetem [Debrecen], The Project is funded by Agence Nationale de la Recherche, Grant no. ANR-18-CE35-0009, Centre National de la Recherche Scientifique, International Associ-ated Laboratory Grant, Magyar Tudományos Akadémia, Grant no. Lendület LP2021/12, and ANR-18-CE35-0009,TRANSCAN,ECOLOGIE ET EVOLUTION DES CANCERS TRANSMISSIBLES(2018)

Subjects
[SDV.BA.ZI]Life Sciences [q-bio]/Animal biology/Invertebrate Zoology, MESH: Humans, MESH: Chlamydiales, Multidisciplinary, MESH: Hydra, MESH: Fresh Water, MESH: Animals, [SDV.CAN]Life Sciences [q-bio]/Cancer, MESH: Female, MESH: Male
Abstract

Hydras are freshwater cnidarians widely used as a biological model to study different questions such as senescence or phenotypic plasticity but also tumoral development. The spontaneous tumors found in these organisms have been so far described in two female lab strains domesticated years ago (Hydra oligactis and Pelmatohydra robusta) and the extent to which these tumors can be representative of tumors within the diversity of wild hydras is completely unknown. In this study, we examined individuals isolated from recently sampled wild strains of different sex and geographical origin, which have developed outgrowths looking like tumors. These tumefactions have common features with the tumors previously described in lab strains: are composed of an accumulation of abnormal cells, resulting in a similar enlargement of the tissue layers. However, we also found diversity within these new types of tumors. Indeed, not only females, but also males seem prone to form these tumors. Finally, the microbiota associated to these tumors is different from the one involved in the previous lineages exhibiting tumors. We found that tumorous individuals hosted yet undescribed Chlamydiales vacuoles. This study brings new insights into the understanding of tumor susceptibility and diversity in brown hydras from different origins.

Published
2023
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2. Asymmetric total synthesis and stereochemical revision of gymnangiamide

Author

Hitoshi Tone, Celine Mordant, Virginie Ratovelomanana-Vidal, Tahar Ayad, Marie Buchotte, Eric Guittet, Institut de Chimie des Substances Naturelles (ICSN), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Laboratoire Charles Friedel, Université Pierre et Marie Curie - Paris 6 (UPMC)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Hydra, Stereochemistry, MESH: Molecular Structure, Marine Biology, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, 010402 general chemistry, 01 natural sciences, Biochemistry, Pentapeptide repeat, Kinetic resolution, chemistry.chemical_compound, Residue (chemistry), MESH: Nuclear Magnetic Resonance, Biomolecular, Animals, MESH: Animals, Physical and Theoretical Chemistry, Nuclear Magnetic Resonance, Biomolecular, ComputingMilieux_MISCELLANEOUS, chemistry.chemical_classification, Natural product, Molecular Structure, 010405 organic chemistry, Chemistry, MESH: Hydra, Organic Chemistry, Asymmetric hydrogenation, Total synthesis, Stereoisomerism, MESH: Marine Biology, MESH: Stereoisomerism, 0104 chemical sciences, Amino acid, NMR spectra database, MESH: Oligopeptides, Oligopeptides
Abstract

International audience; The asymmetric total synthesis of the originally proposed structure of gymnangiamide, a cytotoxic pentapeptide isolated from the marine hydroid Gymnangium regae Jaderholm, has been achieved. Key to the synthesis was the use of asymmetric hydrogenation of alpha-substituted beta-ketoesters through dynamic kinetic resolution for the preparation of nonproteinogenic chiral amino acids. The disparity of the NMR spectra between the synthetic material containing the L-serine residue and the natural product required a revision of the proposed structure.

Published
2009
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