1. Systemic allergic contact dermatitis caused by methyl aminolaevulinate in a patient with keratosis-ichthyosis-deafness syndrome
- Author
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Aysha, Al Malki, Marie-Claude, Marguery, Françoise, Giordano-Labadie, Maria P, Konstantinou, Lorraine, Mokeddem, Laurence, Lamant, Carle, Paul, Aude, Maza, Juliette, Mazereeuw-Hautier, CHU Toulouse [Toulouse], Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées, Institut Universitaire du Cancer de Toulouse - Oncopole (IUCT Oncopole - UMR 1037), CHU Toulouse [Toulouse]-Université Toulouse III - Paul Sabatier (UT3), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)
- Subjects
MESH: Photosensitizing Agents / administration & dosage ,MESH: Patch Tests / methods ,Deafness ,MESH: Cellulitis / complications ,MESH: Cellulitis / drug therapy ,methyl aminolaevulinate ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,MESH: Aminolevulinic Acid / adverse effects ,Humans ,case report ,MESH: Deafness / drug therapy ,MESH: Drug Eruptions / etiology ,MESH: Ichthyosis / complications ,MESH: Keratitis / complications ,MESH: Ichthyosis / drug therapy ,Keratitis ,Photosensitizing Agents ,MESH: Middle Aged ,MESH: Photochemotherapy / adverse effects ,MESH: Humans ,MESH: Keratitis / drug therapy ,Ichthyosis ,Cellulitis ,MESH: Deafness / complications ,Aminolevulinic Acid ,MESH: Aminolevulinic Acid / analogs & derivatives ,Middle Aged ,Patch Tests ,systemic contact dermatitis ,Photochemotherapy ,photodynamic therapy ,MESH: Aminolevulinic Acid / administration & dosage ,MESH: Photosensitizing Agents / adverse effects ,Female ,Drug Eruptions ,KID syndrome ,MESH: Female - Abstract
International audience; Photodynamic therapy (PDT) is used for the treatment ofnon-melanoma skin cancers. A photosensitizer [amino-laevulinic acid (ALA) or methyl aminolaevulinate (MAL)]is applied to the skin and activated by light to producecytotoxic oxygen species. Keratosis–ichthyosis–deafness(KID) syndrome is a form of ichthyosis caused by muta-tions in theGJB2gene. Patients present with vascular-izing keratitis, hearing loss, and increased susceptibilityto some cancers. We report systemic allergic contact der-matitis caused by MAL in a patient with KID syndrome.
- Published
- 2017
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