Search

Your search keyword '"MESH: Chiroptera/genetics"' showing total 5 results
Start Over Descriptor "MESH: Chiroptera/genetics"
5 results on '"MESH: Chiroptera/genetics"'

1. How Social Structure Drives the Population Dynamics of the Common Vampire Bat (Desmodus rotundus, Phyllostomidae)

Author

Álvaro Aguilar Setién, Mailis Huguin, Benoit de Thoisy, Claudia Regina Silva, Anne Lavergne, Arielle Salmier, Nidia Aréchiga-Ceballos, Vincent Lacoste, Marguerite Delaval, Amandine Guidez, Isai Jorge de Castro, Laboratoire des Interactions Virus-Hôtes [Cayenne, Guyane Française], Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Association Kwata (Kwata), Kwata, Instituto de Diagnóstico y Referencia Epidemiológicos, Office National des Forêts [Cayenne], Instituto de Pesquisas Científicas e Tecnológicas do Estado do Amapá (IEPA), Estado do Amapa, Instituto Mexicano del Seguro Social [Mexico City, Mexico] (IMSS), Supported by Kwata NGO, Institut Pasteur de la Guyane, DEAL Guyane, and Collectivité Territoriale de la Guyane., All field volunteers and owners and/or managers of capture sites are warmly acknowledged for their assistance in captures. In compliance with Advantages and Benefits Sharing policy in French Guiana, samples are kept in the tissue collection JAGUARS (http://kwata.net/la-collection-jaguars-pour-l-etude-de-la-biodiversite.html, and CITES reference: FR973A)

Subjects
Male, 0106 biological sciences, 0301 basic medicine, Disease reservoir, 01 natural sciences, MESH: Rabies/transmission, Chiroptera, population dynamics, MESH: Chiroptera/virology, MESH: Disease Reservoirs/virology, MESH: Animals, Genetics (clinical), education.field_of_study, MESH: Chiroptera/physiology, biology, sociality, vampire bat, French Guiana, Female, Brazil, Biotechnology, Rabies, Wahlund effect, Population, MESH: Rabies/virology, Zoology, Desmodus rotundus, 010603 evolutionary biology, MESH: Rabies virus/physiology, 03 medical and health sciences, MESH: Chiroptera/genetics, MESH: French Guiana, Genetics, Animals, MESH: Social Behavior, structure, Social Behavior, education, Mexico, MESH: Mexico, Molecular Biology, Disease Reservoirs, Isolation by distance, [SDV.GEN.GPO]Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE], MESH: Population Dynamics, biology.organism_classification, parasite spreading, MESH: Male, 030104 developmental biology, Rabies virus, Vampire bat, Biological dispersal, Philopatry, MESH: Brazil, MESH: Female
Abstract

International audience; Social systems are major drivers of population structure and gene flow, with important effects on dynamics and dispersal of associated populations of parasites. Among bats, the common vampire bat (Desmodus rotundus) has likely one of the most complex social structures. Using autosomal and mitochondrial markers on vampires from Mexico, French Guiana, and North Brazil, from both roosting and foraging areas, we observed an isolation by distance at the wider scale and lower but significant differentiation between closer populations (

Published
2017

2. A potential robust antiviral defense state in the common vampire bat: Expression, induction and molecular characterization of the three interferon-stimulated genes -OAS1, ADAR1 and PKR

Author

Stéphanie Dabo, Christine Neuveut, Vincent Lacoste, Marie-Claude Lise, Eliane F. Meurs, Anne Lavergne, Sarkis Sarkis, Laboratoire des Interactions Virus-Hôtes [Cayenne, Guyane Française], Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Hépacivirus et Immunité innée, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), This study was conducted within the CAROLIA and BATIMMUNE programs. CAROLIA was supported by European funds (ERDF/FEDER, 31575) and assistance from the Région Guyane and the Direction Régionale pour la Recherche et la Technologie. BATIMMUNE was funded by the Institut Pasteur through a Transversal Research Program (PTR499). This study also received a European Commission 'REGPOT-CT-2011-285837-STRonGer' grant within the FP7 and an 'Investissement d’Avenir' grant managed by the Agence Nationale de la Recherche (CEBA, Ref. ANR-10-LABEX-25-01)., ANR-10-LABX-0025,CEBA,CEnter of the study of Biodiversity in Amazonia(2010), European Project: 285837,EC:FP7:REGPOT,FP7-REGPOT-2011-1,STRONGER(2011), and Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris]

Subjects
0301 basic medicine, Transcription, Genetic, Adenosine Deaminase, [SDV]Life Sciences [q-bio], MESH: Antiviral Agents/pharmacology, MESH: Virus Diseases/genetics, ISGs, [SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity, eIF-2 Kinase, Interferon, Transcription (biology), Chiroptera, 2',5'-Oligoadenylate Synthetase, MESH: Animals, Innate immunity, MESH: Transcription, Genetic/drug effects, MESH: Transcription, Genetic/genetics, PKR, MESH: Adenosine Deaminase/genetics, 3. Good health, PKR 20, Virus Diseases, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, medicine.drug, Immunology, Biology, Desmodus rotundus, Antiviral Agents, OAS1a, OAS1b, Cell Line, 03 medical and health sciences, MESH: Poly I-C/genetics, ADAR1, MESH: Chiroptera/genetics, medicine, MESH: 2',5'-Oligoadenylate Synthetase/genetics, Animals, Gene, MESH: eIF-2 Kinase/genetics, Innate immune system, 030102 biochemistry & molecular biology, MESH: Interferons/pharmacology, biology.organism_classification, Virology, Protein kinase R, MESH: Cell Line, [SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics, 030104 developmental biology, Poly I-C, Cell culture, Vampire bat, Interferons, Developmental Biology
Abstract

Bats are known to harbor many zoonotic viruses, some of which are pathogenic to other mammals while they seem to be harmless in bats. As the interferon (IFN) response represents the first line of defense against viral infections in mammals, it is hypothesized that activation of the IFN system is one of the mechanisms enabling bats to co-exist with viruses. We have previously reported induction of type I IFN in a cell line from the common vampire bat, Desmodus rotundus , upon polyinosinic:polycytidylic acid (poly(I:C)) stimulation. To deepen our knowledge on D. rotundus ’ IFN-I antiviral response, we molecularly characterized three interferon-stimulated genes (ISGs), OAS1 , PKR and ADAR1 , closely implicated in the IFN-I antiviral response, and tested their functionality in our cellular model. We first found that D. rotundus encoded two OAS1 paralogs, OAS1a and OAS1b , and that the functional domains of the four ISGs characterized were highly conserved with those of other mammals. Despite their significant transcription level in the absence of stimulation, the transcription of the four ISGs characterized was enhanced by poly(I:C). In addition, the transcription of OAS1a and OAS1b appears to be differentially regulated. These findings demonstrate an active ISG antiviral response in D. rotundus in which OAS1b may play an important role.

Published
2018

3. Virome analysis of two sympatric bat species (Desmodus rotundus and Molossus molossus) in French Guiana

Author

LACOSTE, Vincent, SALMIER, Arielle, TIRERA, Sourakhata, FRANC, Alain, DARCISSAC, Edith, DONATO, Damien, BOUCHIER, Christiane, LAVERGNE, Anne, DE THOISY, Benoit, FORRESTER, Naomi, Laboratoire des Interactions Virus-Hôtes [Cayenne, Guyane Française], Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Biodiversité, Gènes & Communautés (BioGeCo), Institut National de la Recherche Agronomique (INRA)-Université de Bordeaux (UB), from patterns to models in computational biodiversity and biotechnology (PLEIADE), Laboratoire Bordelais de Recherche en Informatique (LaBRI), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS)-École Nationale Supérieure d'Électronique, Informatique et Radiocommunications de Bordeaux (ENSEIRB)-Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS)-École Nationale Supérieure d'Électronique, Informatique et Radiocommunications de Bordeaux (ENSEIRB)-Inria Bordeaux - Sud-Ouest, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Biodiversité, Gènes & Communautés (BioGeCo), Institut National de la Recherche Agronomique (INRA)-Université de Bordeaux (UB)-Institut National de la Recherche Agronomique (INRA), Génomique (Plate-Forme) - Genomics Platform, Institut Pasteur [Paris], A. Salmier was funded by a grant from European funds (PO FSE 2007-2013) and 'Investissement d’Avenir' managed by Agence Nationale de la Recherche (CEBA, Ref. ANR-10-LABEX-25-01). This study was conducted within the CAROLIA program supported by European funds (ERDF/FEDER) and assistance from Région Guyane and Direction Régionale pour la Recherche et la Technologie. It also received a European Commission 'REGPOT-CT-2011-285837-STRonGer' grant within the FP7 and 'Investissement d’Avenir' grants managed by the Agence Nationale de la Recherche (CEBA, Ref. ANR-10-LABEX-25-01). The Genomics Platform is a member of the France Génomique consortium (ANR10-INBS-09-08)., We acknowledge François Catzeflis and Marguerite Delaval for useful discussions on the biology, ecology and dynamics of bats. All field volunteers and owners and/or managers of capture sites are warmly acknowledged for their assistance in captures. We thank the INDA and C3BI teams at the Institut Pasteur and UMR BIOGECO for their technical support and access to the clusters. We thank L. Ma and M. Tichit for technical assistance., ANR-10-LABX-0025,CEBA,CEnter of the study of Biodiversity in Amazonia(2010), Université de Bordeaux (UB)-Institut National de la Recherche Agronomique (INRA), Centre National de la Recherche Scientifique (CNRS)-École Nationale Supérieure d'Électronique, Informatique et Radiocommunications de Bordeaux (ENSEIRB)-Université Sciences et Technologies - Bordeaux 1-Université Bordeaux Segalen - Bordeaux 2-Centre National de la Recherche Scientifique (CNRS)-École Nationale Supérieure d'Électronique, Informatique et Radiocommunications de Bordeaux (ENSEIRB)-Université Sciences et Technologies - Bordeaux 1-Université Bordeaux Segalen - Bordeaux 2-Inria Bordeaux - Sud-Ouest, Université de Bordeaux (UB)-Institut National de la Recherche Agronomique (INRA)-Université de Bordeaux (UB)-Institut National de la Recherche Agronomique (INRA), Génomique (Plate-Forme), ANR-10-LABX-25-01/10-LABX-0025,CEBA,CEnter of the study of Biodiversity in Amazonia(2010), Université de Bordeaux (UB)-École Nationale Supérieure d'Électronique, Informatique et Radiocommunications de Bordeaux (ENSEIRB)-Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB)-École Nationale Supérieure d'Électronique, Informatique et Radiocommunications de Bordeaux (ENSEIRB)-Centre National de la Recherche Scientifique (CNRS)-Inria Bordeaux - Sud-Ouest, and Institut Pasteur [Paris] (IP)

Subjects
Topography, Molossus molossus, Forests, [SDV.BID.SPT]Life Sciences [q-bio]/Biodiversity/Systematics, Phylogenetics and taxonomy, Pathology and Laboratory Medicine, amazonie, Chiroptera, Bats, MESH: Animals, MESH: Ecosystem, lcsh:Science, MESH: Phylogeny, Phylogeny, Mammals, Fruit Bats, Eukaryota, Phylogenetic Analysis, [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], Terrestrial Environments, French Guiana, Sympatric speciation, Medical Microbiology, Viral Pathogens, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, MESH: Viruses/genetics, MESH: Metagenomics, Bioinformatics, 030106 microbiology, Zoology, Sequence Databases, hématophage, Microbiology, 03 medical and health sciences, Phylogenetics, MESH: Sympatry/genetics, forêt primaire, espèce réservoir, Evolutionary Systematics, Saliva, Microbial Pathogens, Ecosystem, Host (biology), lcsh:R, Ecology and Environmental Sciences, Organisms, Biology and Life Sciences, 15. Life on land, 030104 developmental biology, desmodus rotundus, lcsh:Q, Metagenomics, 0301 basic medicine, MESH: Genome, Viral/genetics, Insecta, Range (biology), Physiology, viruses, MESH: Insecta/virology, lcsh:Medicine, Database and Informatics Methods, Medicine and Health Sciences, MESH: Chiroptera/virology, Data Management, Multidisciplinary, Ecology, MESH: Insect Viruses/genetics, Body Fluids, Sympatry, Caves, Viruses, Vertebrates, Anatomy, Pathogens, épidémie, Sequence Analysis, Research Article, Computer and Information Sciences, Herpesviruses, Insect Viruses, Genome, Viral, Biology, Research and Analysis Methods, Ecosystems, néotropique, chauve souris, MESH: Chiroptera/genetics, MESH: French Guiana, Animals, Human virome, population virale, Taxonomy, [SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, Evolutionary Biology, Landforms, insectivore, Insectivore, Geomorphology, biology.organism_classification, MESH: Sympatry/physiology, Biological Databases, Amniotes, Desmodus rotundus, Earth Sciences, DNA viruses
Abstract

International audience; Environmental disturbances in the Neotropics (e.g., deforestation, agriculture intensifica-tion, urbanization) contribute to an increasing risk of cross-species transmission of microorganisms and to disease outbreaks due to changing ecosystems of reservoir hosts. Although Amazonia encompasses the greatest diversity of reservoir species, the outsized viral population diversity (virome) has yet to be investigated. Here, through a metagenomic approach, we identified 10,991 viral sequences in the saliva and feces of two bat species, Desmodus rotundus (hematophagous), trapped in two different caves surrounded by primary lowland forest, and Molossus molossus (insectivorous), trapped in forest and urban habitats. These sequences are related to 51 viral families known to infect a wide range of hosts (i.e., bacteria , plants, insects and vertebrates). Most viruses detected reflected the diet of bat species, with a high proportion of plant and insect-related viral families for M. molossus and a high proportion of vertebrate-related viral families for D. rotundus, highlighting its influence in shaping the viral diversity of bats. Lastly, we reconstructed the phylogenetic relationships for five vertebrate-related viral families (Nairoviridae, Circoviridae, Retroviridae, Herpesviri-dae, Papillomaviridae). The results showed highly supported clustering with other viral sequences of the same viral family hosted by other bat species, highlighting the potential association of viral diversity with the host's diet. These findings provide significant insight into viral bat diversity in French Guiana belonging to the Amazonian biome and emphasize that habitats and the host's dietary ecology may drive the viral diversity in the bat communities investigated.

Published
2017

4. Development of molecular and cellular tools to decipher the type I IFN pathway of the common vampire bat

Author

Eliane F. Meurs, Christine Neuveut, Vincent Lacoste, Laura Chaulet, Marie-Claude Lise, Sarkis Sarkis, Edith Darcissac, Anne Lavergne, Marcel Falk, Stéphanie Dabo, Laboratoire des Interactions Virus-Hôtes [Cayenne, Guyane Française], Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Hépacivirus et immunité innée, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), This study was conducted within the CAROLIA and BATIMMUNE programs. CAROLIA was supported by European funds (ERDF/FEDER) and assistance from the Region Guyane and the Direction Regionale pour la Recherche et la Technologie. BATIMMUNE wasfunded by the Institut Pasteur through a Transversal Research Program (PTR499). This study also received a European Commission 'REGPOT-CT-2011-285837-STRonGer' grant within the FP7 and an 'Investissement d'Avenir ' grant managed by the Agence Nationale de la Recherche (CEBA, Ref. ANR-10-LABEX-25-01)., ANR-10-LABX-0025,CEBA,CEnter of the study of Biodiversity in Amazonia(2010), European Project: 285837,EC:FP7:REGPOT,FP7-REGPOT-2011-1,STRONGER(2011), and Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS)

Subjects
0301 basic medicine, MESH: Signal Transduction, medicine.disease_cause, [SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity, MESH: DEAD Box Protein 58/genetics, 0302 clinical medicine, MESH: Lung/immunology, Chiroptera, MESH: RNA, Double-Stranded/immunology, MESH: Animals, Cloning, Molecular, Lung, Cell Line, Transformed, Innate immunity, biology, Toll-Like Receptors, Pattern recognition receptor, MESH: Gene Expression Regulation, 3. Good health, MESH: Toll-Like Receptors/genetics, RIG-I-Like receptor, MESH: Chiroptera/genetics, Host-Pathogen Interactions, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, DEAD Box Protein 58, MESH: Immunity, Innate, Cellular model, Signal transduction, Signal Transduction, 030231 tropical medicine, Immunology, Computational biology, Desmodus rotundus, 03 medical and health sciences, MESH: Rabies virus/physiology, Toll-like receptor, MESH: Interferon-alpha/metabolism, medicine, Animals, Humans, MESH: Poly I-C/immunology, MESH: Cloning, Molecular, MESH: Cell Line, Transformed, Type I interferon, Disease Reservoirs, RNA, Double-Stranded, MESH: Disease Reservoirs, Innate immune system, MESH: Humans, Rabies virus, MESH: Host-Pathogen Interactions, MESH: Chiroptera/immunology, Interferon-alpha, Interferon-beta, MESH: Interferon-beta/metabolism, MESH: Lung/cytology, biology.organism_classification, Virology, Immunity, Innate, 030104 developmental biology, Poly I-C, Gene Expression Regulation, Vampire bat, TLR3, Cell line, Developmental Biology
Abstract

International audience; Though the common vampire bat, Desmodus rotundus, is known as the main rabies virus reservoir in Latin America, no tools are available to investigate its antiviral innate immune system. To characterize the IFN-I pathway, we established an immortalized cell line from a D. rotundus fetal lung named FLuDero. Then we molecularly characterized some of the Toll-like receptors (TLR3, 7, 8 and 9), the three RIG-I-like receptor members, as well as IFNa1 and IFNb. Challenging the FLuDero cell line with poly (I:C) resulted in an up-regulation of both IFNa1 and IFNb and the induction of expression of the different pattern recognition receptors characterized. These findings provide evidence of the intact dsRNA recognition machinery and the IFN-I signaling pathway in our cellular model. Herein, we generated a sum of insightful specific molecular and cellular tools that will serve as a useful model to study virusehost interactions of the common vampire bat.

Published
2017

5. Spatial pattern of genetic diversity and selection in the MHC class II DRB of three Neotropical bat species

Author

Benoit de Thoisy, Brigitte Crouau-Roy, Vincent Lacoste, Arielle Salmier, Anne Lavergne, Laboratoire des Interactions Virus-Hôtes [Cayenne, Guyane Française], Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Evolution et Diversité Biologique (EDB), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), A. Salmier was supported by a grant from European funds (PO FSE 2007-2013) and 'Investissement d’Avenir' managed by Agence Nationale de la Recherche (CEBA, Ref. ANR-10- LABEX-25-01). This study was conducted within the CAROLIA program supported by European funds (ERDF/FEDER) and assistance from Région Guyane and Direction Régionale pour la Recherche et la Technologie. It also received a European Commission 'REGPOT-CT-2011-285837- STRonGer' grant within the FP7 and 'Investissement d’Avenir' grants managed by the Agence Nationale de la Recherche (CEBA, Ref. ANR-10- LABEX-25-01). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript., We are grateful to François Catzeflis and Marguerite Delaval for useful discussions on the biology, ecology and dynamics of bats. All field volunteers and owners and/or managers of capture sites are warmly acknowledged for their assistance in captures., ANR-10-LABX-0025,CEBA,CEnter of the study of Biodiversity in Amazonia(2010), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées

Subjects
0106 biological sciences, 0301 basic medicine, Molossus molossus, 01 natural sciences, Chiroptera, MESH: Gene Conversion, MESH: Animals, MESH: Histocompatibility Antigens Class II/genetics, MESH: Phylogeny, Phylogeny, Carollia perspicillata, education.field_of_study, MESH: Genetic Variation, biology, Phylogenetic tree, [SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE], MESH: Genes, MHC Class II, [SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology, Sympatric speciation, Host-Pathogen Interactions, Research Article, DRB polymorphism, Genes, MHC Class II, Population, MESH: Host-Pathogen Interactions/genetics, Gene Conversion, MESH: Selection, Genetic, Zoology, Desmodus rotundus, 010603 evolutionary biology, MESH: Gastrointestinal Microbiome, Evolution, Molecular, 03 medical and health sciences, MESH: Histocompatibility Antigens Class II/chemistry, MESH: Chiroptera/genetics, MESH: Evolution, Molecular, MESH: Polymorphism, Genetic, Genetic variation, Animals, Selection, Genetic, education, Selection, Alleles, Ecology, Evolution, Behavior and Systematics, Genetic diversity, [SDV.GEN.GPO]Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE], Polymorphism, Genetic, MESH: Alleles, Histocompatibility Antigens Class II, Genetic Variation, 15. Life on land, biology.organism_classification, Gastrointestinal Microbiome, 030104 developmental biology, MHC
Abstract

Background Although bats are natural reservoirs of many pathogens, few studies have been conducted on the genetic variation and detection of selection in major histocompatibility complex (MHC) genes. These genes are critical for resistance and susceptibility to diseases, and host–pathogen interactions are major determinants of their extensive polymorphism. Here we examined spatial patterns of diversity of the expressed MHC class II DRB gene of three sympatric Neotropical bats, Carollia perspicillata and Desmodus rotundus (Phyllostomidae), and Molossus molossus (Molossidae), all of which use the same environments (e.g., forests, edge habitats, urban areas). Comparison with neutral marker (mtDNA D-loop) diversity was performed at the same time. Results Twenty-three DRB alleles were identified in 19 C. perspicillata, 30 alleles in 35 D. rotundus and 20 alleles in 28 M. molossus. The occurrence of multiple DRB loci was found for the two Phyllostomidae species. The DRB polymorphism was high in all sampling sites and different signatures of positive selection were detected depending on the environment. The patterns of DRB diversity were similar to those of neutral markers for C. perspicillata and M. molossus. In contrast, these patterns were different for D. rotundus for which a geographical structure was highlighted. A heterozygote advantage was also identified for this species. No recombination or gene conversion event was found and phylogenetic relationships showed a trans-species mode of evolution in the Phyllostomids. Conclusions This study of MHC diversity demonstrated the strength of the environment and contrasting pathogen pressures in shaping DRB diversity. Differences between positively selected sites identified in bat species highlighted the potential role of gut microbiota in shaping immune responses. Furthermore, multiple geographic origins and/or population admixtures observed in C. perspicillata and M. molossus populations acted as an additional force in shaping DRB diversity. In contrast, DRB diversity of D. rotundus was shaped by environment rather than demographic history. Electronic supplementary material The online version of this article (doi:10.1186/s12862-016-0802-1) contains supplementary material, which is available to authorized users.

Published
2016

Catalog

Books, media, physical & digital resources
See catalog results