Descriptor: "MESH: Cause of Death" - Searchworks@Jio Institute Digital Library Search Results

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70 results on '"MESH: Cause of Death"'

1. Long-Term Clinical Outcomes According to Previous Manifestations of Atherosclerotic Disease (from the FAST-MI 2010 Registry)

Author: Etienne Puymirat, Nicolas Danchin, Yves Cottin, Nadia Aissaoui, Tabassome Simon, Jean Ferrières, Gilles Lemesle, Francois Schiele, Pierre Coste, Paris-Centre de Recherche Cardiovasculaire (PARCC - UMR-S U970), Université Paris Descartes - Paris 5 (UPD5)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris Descartes - Paris 5 (UPD5), Hôpital Européen Georges Pompidou [APHP] (HEGP), Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Université Lille 2 - Faculté de Médecine, Lipides - Nutrition - Cancer [Dijon - U1231] (LNC), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Service de Cardiologie [CHU de Dijon], Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Hôpital cardiologique du Haut Leveque, Université de Bordeaux Ségalen [Bordeaux 2], Département de Cardiologie (Dep Cardio - BESANCON), Centre Hospitalier Régional Universitaire [Besançon] (CHRU Besançon), Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps (LEASP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de cardiologie [Toulouse], Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Hôpital de Rangueil, CHU Toulouse [Toulouse], CHU Saint-Antoine [APHP], Université Pierre et Marie Curie - Paris 6 (UPMC), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Service de cardiologie [CHRU de Besançon], Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Hôpital de Rangueil, CHU Toulouse [Toulouse]-CHU Toulouse [Toulouse], CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Paris-Centre de Recherche Cardiovasculaire ( PARCC - U970 ), Hôpital Européen Georges Pompidou [APHP] ( HEGP ) -Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Université Paris Descartes - Paris 5 ( UPD5 ), Hôpital Européen Georges Pompidou [APHP] ( HEGP ), Centre Hospitalier Régional Universitaire [Lille] ( CHRU Lille ), Lipides - Nutrition - Cancer [Dijon - U1231] ( LNC ), Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand ( CHU Dijon ), Département de Cardiologie ( Dep Cardio - BESANCON ), Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ), Épidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps, Université Toulouse III - Paul Sabatier ( UPS ), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Plateforme de recherche clinique de l'est parisien ( URCEST-CRCEST ), Service de pharmacologie clinique [CHU Saint-Antoine], Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Saint-Antoine [APHP], Université Pierre et Marie Curie - Paris 6 ( UPMC ), Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps [Toulouse], Université Paul Sabatier - Toulouse 3 ( UPS ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Université Paul Sabatier - Toulouse 3 ( UPS ) -CHU Toulouse [Toulouse]-Hôpital de Rangueil, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Faculté de Médecine Henri Warembourg - Université de Lille, Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service Cardiologie [CHU Toulouse], Pôle Cardiovasculaire et Métabolique [CHU Toulouse], and Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)
Subjects: Male, MESH : Atherosclerosis, medicine.medical_treatment, MESH : Mortality, Myocardial Infarction, MESH : Aged, MESH : Prospective Studies, Angiotensin-Converting Enzyme Inhibitors, Coronary Artery Disease, Disease, MESH : Cerebrovascular Disorders, 0302 clinical medicine, Medicine, Longitudinal Studies, Prospective Studies, MESH: Coronary Artery Disease, Myocardial infarction, Coronary Artery Bypass, MESH: Treatment Outcome, Cause of death, Aged, 80 and over, education.field_of_study, MESH: Middle Aged, Hazard ratio, MESH : Platelet Aggregation Inhibitors, Prognosis, MESH: Case-Control Studies, 3. Good health, MESH: Myocardial Infarction, MESH: Angiotensin Receptor Antagonists, MESH : Angiotensin-Converting Enzyme Inhibitors, Cardiology and Cardiovascular Medicine, MESH: Percutaneous Coronary Intervention, MESH : Case-Control Studies, medicine.medical_specialty, MESH : Angiotensin Receptor Antagonists, MESH: Prognosis, 03 medical and health sciences, Percutaneous Coronary Intervention, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Humans, MESH : Middle Aged, MESH : Coronary Artery Disease, MESH : Aged, 80 and over, MESH: Hydroxymethylglutaryl-CoA Reductase Inhibitors, education, MESH: Age Distribution, Aged, MESH: Humans, MESH: Mortality, Proportional hazards model, MESH: Coronary Artery Bypass, MESH : Humans, Case-control study, MESH : Proportional Hazards Models, medicine.disease, MESH : Coronary Artery Bypass, Case-Control Studies, MESH: Female, MESH: Registries, MESH : Age Distribution, 030204 cardiovascular system & hematology, MESH: Atherosclerosis, MESH: Proportional Hazards Models, MESH: Cause of Death, MESH: Aged, 80 and over, MESH : Percutaneous Coronary Intervention, Risk Factors, MESH: Risk Factors, Cause of Death, MESH : Female, Registries, 030212 general & internal medicine, MESH: Longitudinal Studies, MESH : Longitudinal Studies, MESH: Aged, MESH : Prognosis, MESH: Angiotensin-Converting Enzyme Inhibitors, MESH: Adrenergic beta-Antagonists, Middle Aged, [ SDV.MHEP.CSC ] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, MESH : Risk Factors, Treatment Outcome, MESH: Platelet Aggregation Inhibitors, Cardiology, Female, MESH: Cerebrovascular Disorders, France, MESH : Male, Adrenergic beta-Antagonists, MESH : Adrenergic beta-Antagonists, Population, MESH : Treatment Outcome, MESH: Multivariate Analysis, Angiotensin Receptor Antagonists, Age Distribution, Internal medicine, Mortality, MESH : France, Proportional Hazards Models, MESH : Cause of Death, business.industry, MESH : Hydroxymethylglutaryl-CoA Reductase Inhibitors, MESH : Multivariate Analysis, Percutaneous coronary intervention, Atherosclerosis, MESH: Male, MESH: Prospective Studies, MESH: France, Cerebrovascular Disorders, Multivariate Analysis, Hydroxymethylglutaryl-CoA Reductase Inhibitors, MESH : Myocardial Infarction, business, Platelet Aggregation Inhibitors, MESH : Registries
Abstract: IF 3.398; International audience; The prognosis of patients with acute myocardial infarction (AMI) has notably improved in the past 20 years. Using the French Registry of ST-Elevation and Non-ST-elevation Myocardial Infarction (FAST-MI) 2010 registry, we investigated whether previous manifestations of atherosclerotic disease (i.e., previous MI, or a history of any form of atherosclerotic disease) are at truly increased risk compared with those in whom AMI is the first manifestation of the disease. FAST-MI 2010 is a nationwide French registry including 3,079 patients with AMI, among whom 1,062 patients had a history of cardiovascular atherosclerotic disease and 498 patients had a history of MI. Overall, patients with a history of atherosclerotic disease (or MI) were older compared with patients without known cardiovascular disease (71 ± 13 vs 63 ± 14 years) and had higher cardiovascular risk profiles and co-morbidities. Using fully adjusted Cox multivariate analysis, previous manifestations of atherosclerotic disease were associated with higher 3-year mortality (hazard ratio 1.80, 95% confidence interval 1.40 to 2.31; p
Published: 2017
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2. Cancer and end of life: the management provided during the year and the month preceding death in 2015 and causes of death in France

Author: Anne Fagot-Campagna, Philippe-Jean Bousquet, T. Lesuffleur, Christelle Gastaldi-Ménager, Philippe Tuppin, Audrey Tanguy Melac, Caisse Nationale d'Assurance Maladie des Travailleurs salariés (CNAMTS), Ministère de l'économie et des finances, Institut national du cancer [Boulogne] (INCA), and Dupuis, Christine
Subjects: Male, Pediatrics, Palliative care, [SDV]Life Sciences [q-bio], MESH: Hospitalization, law.invention, MESH: Cause of Death, 0302 clinical medicine, MESH: Aged, 80 and over, law, Cause of Death, Neoplasms, MESH: Neoplasms, 030212 general & internal medicine, Cause of death, Cancer, MESH: Aged, Aged, 80 and over, education.field_of_study, Terminal Care, MESH: Middle Aged, Middle Aged, Intensive care unit, 3. Good health, [SDV] Life Sciences [q-bio], Hospitalization, MESH: Terminal Care, Oncology, 030220 oncology & carcinogenesis, Female, France, MESH: History, 21st Century, Adult, medicine.medical_specialty, Population, History, 21st Century, 03 medical and health sciences, Breast cancer, Place of death, medicine, Humans, education, Lung cancer, Aged, MESH: Humans, business.industry, MESH: Adult, Emergency department, medicine.disease, MESH: Male, MESH: France, End of life, business, MESH: Female
Abstract: International audience; Purpose: The management of cancer patients at the end of life in France and their causes of death are not well known.Methods: People managed for cancer in 2014-2015, who died in 2015 and who were covered by the national health insurance general scheme (77% of the French population) were selected from the national health data system in order to analyze the health care reimbursed during the year and the month before their death.Results: This study included 125,497 people (mean age 73 years, SD 12.5) managed for cancer: colorectal: 12%, lung: 18%, prostate: 9%, breast: 8% and other: 62%. Almost 67% of people died in short-stay hospitals (SSH), 8% died in rehabilitation units (Rehab), 4% died in hospital at home (HaH), 5% died in skilled nursing homes (SNH) and 15% died at home or another place. The mean annual duration of all types of hospitalization was 70 days (SD 66) and 59% of patients had received hospital palliative care (HPC). During the last month of life, 42% of people had attended an emergency department at least once and people who had received HPC were less often admitted to an intensive care unit (10% versus 23%, 15% overall). During the month before death, 17% of patients had received intravenous chemotherapy (lung 23%, breast 21%) and 9% had received a pharmacy reimbursement for another form of chemotherapy (prostate 24%, breast 19%). The main cause of death was a tumour for 81% of patients: after management of lung cancer in 91% of cases, breast cancer in 81% of cases, colorectal cancer in 76% of cases and prostate cancer in 63% of cases.Conclusions: Cancer management and death mostly occurred in SSH in France. Cancer patients frequently attend the emergency department and frequently receive chemotherapy during the last month of life. These data continue to contrast with those observed in Scandinavian- and English-speaking countries, in which management of the end of life at home is preferred.
Published: 2019
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3. Étude des évolutions de la mortalité par cause médicale en France entre 2000 et 2014

Author: Boulat, Thierry, Université Paris Descartes - Faculté de Médecine (UPD5 Médecine), Université Paris Descartes - Paris 5 (UPD5), and Grégoire Rey
Subjects: MESH: Cause of Death, MESH: Population Growth, Imputation multiple, MESH: Mortality, Multiple imputation, Causes de décès, Trends, Mortalité, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Tendances
Abstract: Objective: this study aims at analysing the distribution of mortality in 2014 and its evolution since 2000 by cause of death and by sex, taking into account evolutions linked to data collection and methods of production. Method: data is collected from death certificates completed by the physician upon death. A generalized additive model is used to detect and assess the value of the level jumps by death category for the year 2011, year of the change of the automatic coding software. A multiple imputation of the unknown causes of death is carried out, then a GEE model with correction of the 2011 level jump makes it possible to estimate trend of the death rates by cause of death and sex between the periods 2000-2007 and 2008-2014. Results: in 2014, 544,740 deaths were recorded in metropolitan France. The standardised all-cause mortality rate decreased by 25% between 2000 and 2014 (from 1150.0 to 862.3 per 100,000 population). The largest relative increase in effectives after imputation is found for transport accidents (+ 16.5% in 2014). The largest decrease between 2000-2007 and 2008-2014 is found for AIDS and HIV diseases for men (RR = 0.54 [0.43 - 0.67] p
Published: 2018

4. Impact of age-related comorbidities on five-year overall mortality among elderly HIV-infected patients in the late HAART era — Role of chronic renal disease

Author: Maxime HENTZIEN, Dramé, M., Allavena, C., Jacomet, C., Valantin, A., André Cabié, Cuzin, L., Rey, D., Pugliese, P., Bani-Sadr, F., Hentzien, F., Dramé, D., Allavena, A., Centre Hospitalier Universitaire de Reims (CHU Reims), Service des maladies infectieuses et tropicales [CHU Nantes], Centre hospitalier universitaire de Nantes (CHU Nantes), Service des Maladies Infectieuses et Tropicales [CHU Clermont-Ferrand], CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Service de Maladies Infectieuses et Tropicales [Fort-de-France, Martinique], CHU de la Martinique [Fort de France]-Hôpital Pierre Zobda-Quitman [CHU de la Martinique], CHU de la Martinique [Fort de France]-Centre Hospitalier Universitaire de Martinique [Fort-de-France, Martinique], Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps (LEASP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Nouvel Hôpital Civil de Strasbourg, Service d'infectiologie [CHU Nice], Centre Hospitalier Universitaire de Nice (CHU Nice), IER - Institut d'Economie Rurale (IER), IER, Department of Genetics, Biology and Biochemistry, University of Turin, Service de Médecine interne, Maladies Infectieuses et Immunologie Clinique [Reims], Vieillissement, Fragilité (VIEFRA - EA 3797), Université de Reims Champagne-Ardenne (URCA), Service des maladies infectieuses [Clermont-Ferrand], CHU Clermont-Ferrand, Service des maladies infectieuses et tropicales [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane), CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles et de la Guyane (UAG), and CHU Strasbourg
Subjects: Male, Aging, Medicine (miscellaneous), HIV Infections, MESH: Comorbidity, Comorbidity, MESH: Antiretroviral Therapy, Highly Active, Cohort Studies, surgery, MESH: Proportional Hazards Models, MESH: Cause of Death, 0302 clinical medicine, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Antiretroviral Therapy, Highly Active, Cause of Death, Neoplasms, Prevalence, MESH: Aging, MESH: Neoplasms, Prospective Studies, 030212 general & internal medicine, MESH: Anti-HIV Agents, Prospective cohort study, MESH: Cohort Studies, ComputingMilieux_MISCELLANEOUS, MESH: Aged, 2. Zero hunger, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, MESH: Middle Aged, Nutrition and Dietetics, Mortality rate, Hazard ratio, MESH: HIV Infections, Hepatitis C, Middle Aged, Hepatitis B, 3. Good health, Cardiovascular Diseases, MESH: Fibrosis, Cohort, Female, 030211 gastroenterology & hepatology, France, Cohort study, medicine.medical_specialty, MESH: Diabetes Mellitus, Anti-HIV Agents, MESH: Renal Insufficiency, Chronic, valves, 03 medical and health sciences, Internal medicine, Diabetes Mellitus, medicine, Humans, Renal Insufficiency, Chronic, Intensive care medicine, MESH: Prevalence, Aged, Proportional Hazards Models, MESH: Hepatitis C, MESH: Humans, business.industry, MESH: Cardiovascular Diseases, medicine.disease, Fibrosis, mortality, infection, MESH: Male, MESH: Prospective Studies, MESH: France, prognosis, Geriatrics and Gerontology, business, MESH: Female, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: International audience; To identify main prognostic factors for 5-year mortality among age-related comorbidities (ARCs) in older people living with HIV (PLHIV).; A prospective, multicentre cohort study with a 5-year follow-up period in the late HAART era (from January 2008 to December 2012).; The Dat'AIDS cohort involving 12 French hospitals.; All actively followed HIV-1 infected patients aged 60 or older.; The study endpoint was all-cause five-year mortality. The following ARCs were considered: chronic renal disease, cardiovascular diseases, cancer, chronic pulmonary disease, cirrhosis, diabetes and nutritional status. Hepatitis C (HCV), hepatitis B (HBV) co-infection and sociodemographic characteristics were also evaluated. Cox's Proportional Hazards model was used for multivariate analysis.; Among 1415 PLHIV aged 60 or more patients included, mean age was 66±5.5 years; 154 died (mortality rate 2.47/100 patient-years). The most prevalent ARCs were chronic renal disease (20.1%), diabetes (14.2%) and cardiovascular diseases (12.2%). By multivariate analysis, chronic renal disease (adjusted hazard ratio (aHR)=2.25; 95% confidence interval (CI) [1.58-2.21]; p
Published: 2015
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5. Heart failure with systolic dysfunction complicating acute myocardial infarction – differential outcomes but similar eplerenone efficacy by ST-segment or non-ST-segment elevation: A post hoc substudy of the EPHESUS trial

Author: Bertram Pitt, Santosh C. Sutradhor, Michael Angioi, Sylvain Carillo, John Vincent, Renaud Fay, Ali Ahmed, Yan Zhang, Faiez Zannad, Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] (CIC-P), Centre d'investigation clinique [Nancy] (CIC), Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Alabama at Birmingham [ Birmingham] (UAB), Birmingham VA Medical Center, University of Alabama [Tuscaloosa] (UA), Clinique Louis-Pasteur, Pfizer, University of California [Davis] (UC Davis), University of California, University of Michigan [Ann Arbor], University of Michigan System, Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), and Université de Lorraine (UL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)
Subjects: MESH: Coronary Thrombosis, Male, medicine.medical_treatment, Myocardial Infarction, MESH: Comorbidity, MESH: Myocardial Revascularization, Comorbidity, Spironolactone, MESH: Proportional Hazards Models, MESH: Cause of Death, Electrocardiography, Mineralocorticoid receptor, Cause of Death, Myocardial Revascularization, ST segment, Multicenter Studies as Topic, Myocardial infarction, MESH: Treatment Outcome, Mineralocorticoid Receptor Antagonists, Randomized Controlled Trials as Topic, MESH: Aged, MESH: Middle Aged, Ejection fraction, General Medicine, Middle Aged, Prognosis, 3. Good health, Eplerenone, MESH: Myocardial Infarction, Treatment Outcome, Cardiovascular Diseases, MESH: Spironolactone, Cardiology, Disease Progression, MESH: Disease Progression, Female, MESH: Cardiovascular Agents, IDM ST+, Cardiology and Cardiovascular Medicine, medicine.drug, medicine.medical_specialty, Post hoc, MESH: Mineralocorticoid Receptor Antagonists, Éplérénone, Revascularization, MESH: Prognosis, STEMI, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, IDM ST–, Internal medicine, medicine, Humans, cardiovascular diseases, Aged, Proportional Hazards Models, Retrospective Studies, Heart Failure, MESH: Humans, business.industry, Coronary Thrombosis, MESH: Cardiovascular Diseases, MESH: Retrospective Studies, Cardiovascular Agents, medicine.disease, MESH: Male, MESH: Electrocardiography, Insuffisance cardiaque, NSTEMI, MESH: Randomized Controlled Trials as Topic, Heart failure, MESH: Heart Failure, MESH: Multicenter Studies as Topic, business, MESH: Female
Abstract: International audience; BACKGROUND:Differential outcomes in patients with acute systolic heart failure (HF) complicating acute myocardial infarction (AMI) and the efficacy of mineralocorticoid receptor antagonists according to non-ST-segment and ST-segment elevation myocardial infarction (NSTEMI, STEMI) status has not been specifically investigated.METHODS:In the EPHESUS study, 6632 patients with acute HF and left ventricular ejection fraction
Published: 2014
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6. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal carcinomatosis in the elderly: A case-controlled, multicenter study

Author: Alyami, Mohammad, Lundberg, Peter, Kepenekian, Vahan, Goere, Diane, Bereder, Jean-Marc, Msika, Simon, Lorimier, Gérard, Quenet, François, Ferron, Gwenaël, Thibaudeau, Emilie, Abboud, Karine, Lo Dico, Réa, Delroeux, Delphine, Brigand, Cécile, Arvieux, Catherine, Marchal , Frédéric, Tuech, Jean-Jacques, Guilloit, Jean-Marc, Guyon, Frédéric, Peyrat, Patrice, Pezet, Denis, Ortega-Deballon, Pablo, Zinzindohoué, Franck, de Chaisemartin, Cécile, Kianmanesh, Reza, Glehen, Olivier, Passot, Guillaume, Group, BIG-RENAPE, Group, RENAPE, Service d'Oncologie Médicale [Centre hospitalier Lyon Sud - HCL], Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Département de chirurgie générale [Gustave Roussy], Institut Gustave Roussy (IGR), Centre Hospitalier Universitaire de Nice (CHU Nice), Hôpital Louis Mourier - AP-HP [Colombes], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Département de chirurgie, CRLCC Val d'Aurelle - Paul Lamarque, Institut Claudius Regaud, Institut de Cancérologie de l'Ouest [Angers/Nantes] (UNICANCER/ICO), UNICANCER, CHU Saint-Etienne, Service de Chirurgie d'Oncologie Digestive [CHU Lariboisière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Lariboisière-Fernand-Widal [APHP], Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Hôpital de Hautepierre [Strasbourg], CHU Grenoble, Centre de Recherche en Automatique de Nancy (CRAN), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Institut de Cancérologie de Lorraine - Alexis Vautrin [Nancy] (UNICANCER/ICL), Service de chirurgie digestive [CHU Rouen], Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU), Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU), Institut Bergonié [Bordeaux], UNICANCER-UNICANCER, Centre Léon Bérard [Lyon], CHU Clermont-Ferrand, Service de Chirurgie Digestive, Cancérologique, Générale, Endocrinienne et Urgences (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Service de chirurgie digestive, générale et cancérologique [CHU HEGP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC), Centre Hospitalier Universitaire de Reims (CHU Reims), Ciblage thérapeutique en Oncologie (EA3738), Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon
Subjects: Male, MESH: Combined Modality Therapy, Health Status, 030230 surgery, MESH: Cause of Death, 0302 clinical medicine, MESH: Aged, 80 and over, Cause of Death, Antineoplastic Combined Chemotherapy Protocols, MESH: Peritoneal Neoplasms, Young adult, Peritoneal Neoplasms, MESH: Health Status, Cause of death, Aged, 80 and over, MESH: Aged, MESH: Middle Aged, Age Factors, Cytoreduction Surgical Procedures, Middle Aged, Combined Modality Therapy, MESH: Case-Control Studies, 3. Good health, MESH: Antineoplastic Combined Chemotherapy Protocols, Oncology, Failure to Rescue, Health Care, Cardiovascular Diseases, MESH: Young Adult, 030220 oncology & carcinogenesis, Cohort, Hyperthermic intraperitoneal chemotherapy, Female, Adult, medicine.medical_specialty, Adolescent, MESH: Failure to Rescue, Health Care, [SDV.CAN]Life Sciences [q-bio]/Cancer, 03 medical and health sciences, Young Adult, medicine, Humans, MESH: Cytoreduction Surgical Procedures, MESH: Hyperthermia, Induced, Aged, Retrospective Studies, MESH: Adolescent, MESH: Age Factors, MESH: Humans, business.industry, Case-control study, MESH: Cardiovascular Diseases, Retrospective cohort study, MESH: Adult, MESH: Retrospective Studies, Hyperthermia, Induced, MESH: Male, Surgery, Case-Control Studies, Conventional PCI, Peritoneal Cancer Index, business, MESH: Female, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: International audience; OBJECTIVE:This study was designed to identify factors associated with morbidity and mortality in patients older than 70 years who underwent cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal carcinomatosis (PC).BACKGROUND:Major surgery is associated with higher morbidity and mortality in elderly patients. For PC, CRS and HIPEC is the only current potential curative therapy, but the risks inherent to this patient population have called its benefits into question.METHODS:We retrospectively analyzed a multi-center database from 1989 to 2015. All patients who underwent CRS and HIPEC for PC were selected and patients older than 70 years were matched 1:4 with a younger cohort according to cancer origin, peritoneal cancer index (PCI), and completeness of cytoreduction. Major morbidity and mortality were analyzed.RESULTS:Of 2328 patients, 188 patients older than aged 70 years were matched with 704 younger patients. Patients older than aged 70 years demonstrated a higher American Society of Anesthesiologist score (≥ASA III 10.8 vs. 6.6 %, p = 0.008). There was no difference in overall 90-day morbidity (≥70: 45.7 % vs. 7 (95 % CI 1.051-5.798, p = 0.038) and HIPEC duration (95 % CI 1.106-6.235, p = 0.028) were independent factors associated with morbidity in elderly patients.CONCLUSIONS:CRS and HIPEC appear feasible for selected patients older than aged 70 years, albeit with a higher risk of medical complications associated with increased mortality.
Published: 2016
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7. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010

Author: Lakshmi Vijayakumar, H. Ross Anderson, David Singh, Doruk Ozgediz, Ted R. Miller, David Chou, Sumeet S. Chugh, Patricia J. Erwin, Samath D Dharmaratne, Steven E. Lipshultz, Roderick J. Hay, Pon Hsiu Yeh, Luigi Naldi, Valery L. Feigin, Patricia Espindola, Laurie M. Anderson, Beth E. Ebel, Ziad A. Memish, Victor Aboyans, Fiona M. Blyth, Derrick A Bennett, Richard H. Osborne, Mohammad H. Forouzanfar, Maria Segui-Gomez, Ella Sanman, Myles Connor, Esteban Porrini, Don C. Des Jarlais, John R. Condon, Gretchen L. Birbeck, Luc E. Coffeng, Tim Driscoll, David Bartels, Bishnu Pahari, G. Remuzzi, F.G.R. Fowkes, Kyle J Foreman, Joshua A. Salomon, Suzanne Barker-Collo, Mengru Wang, Leslie T. Cooper, Diego Gonzalez-Medina, Ali A. Mokdad, Andrea Panozo Rivero, George A. Mensah, Diana Haring, Julie O. Denenberg, Murugesan Raju, Ralph L. Sacco, Robin Marks, Ian Bolliger, Jeffrey A. Towbin, Rita Krishnamurthi, Dharani Ranganathan, David Phillips, Benjamin C Cowie, Paul S. F. Yip, Charles Mock, Bruno Hoen, Robert G. Weintraub, Frederick P. Rivara, Kaustubh Dabhadkar, Jonathan R. Carapetis, K. Ellicott Colson, Wenzhi Wang, Diego De Leo, Lisa M. Knowlton, Guy B. Marks, Michael S Lipnick, Rashmi Jasrasaria, Flavio Gaspari, Richard F. Gillum, John J. McGrath, Jacqueline Mabweijano, Rogelio Perez Padilla, Marlene Fransen, Allyne Delossantos, Theo Vos, Rafael Lozano, Damian G Hoy, Thomas Roberts, Anthony D. Woolf, Zhi Jie Zheng, Karen Sliwa, Andrew E. Moran, Boris Bikbov, Jessica Singleton, Spencer L. James, Mohsen Naghavi, Kim Mulholland, Saad B. Omer, Yara A. Halasa, Sherine E. Gabriel, Leslie Mallinger, Peter Burney, Imad M. Tleyjeh, Majid Ezzati, Jennifer A. Taylor, Thomas Truelsen, Akira Matsumori, Emelia J. Benjamin, Mary M. McDermott, Kiumarss Nasseri, James Harrison, Honglei Chen, Emmanuela Gakidou, M. Nathan Nair, Jerry Abraham, Karen Courville De Vaccaro, Kenji Shibuya, Rakesh Aggarwal, Stephanie Y. Ahn, Steven D. Colan, Christopher J L Murray, Aref A. Bin Abdulhak, Michael Burch, Tony R. Merriman, Nabila Dahodwala, Sudha Jayaraman, Catherine Michaud, Louisa Degenhardt, C. Arden Pope, Monica Cortinovis, Richard Matzopoulos, Norberto Perico, Matthew A. Corriere, Kelsey Pierce, Charles Atkinson, Tim Adair, Abraham D. Flaxman, Michael F. Macintyre, Gregory R. Wagner, Paul Norman, Herbert C. Duber, Kathryn H. Jacobsen, Peter J. Hotez, Andre Keren, Felipe Rodriguez De Leòn, Samantha M. Colquhoun, Michael H. Criqui, Kavi Bhalla, Soufiane Boufous, Narayanaswamy Venketasubramanian, Alan D. Lopez, Larry M. Baddour, Ana Olga Mocumbi, David B. Rein, Jürgen Rehm, Stephen S Lim, Farshad Pourmalek, Nicole E. Johns, Ganesan Karthikeyan, Martin A. Weinstock, Lyn March, Donald S. Shepard, K.M. Venkat Narayan, Michael Freeman, Chiara Bucello, Nicholas J Kassebaum, Adofo Koranteng, Eduardo A. Undurraga, Kerrianne Watt, Mohammad A. AlMazroa, Marita Cross, Fernando Perez-Ruiz, Rasmus Havmoeller, Uchechukwu Sampson, Emma Smith, Bongani M. Mayosi, Summer Lockett Ohno, Michelle L. Bell, John H. McAnulty, E. Ray Dorsey, Lesley Rushton, Matthew J. Miller, Azadeh Zabetian, James D. Wilkinson, David C. Schwebel, Olive Kobusingye, Katrina F Ortblad, Martin O'Donnell, Jon Paul Khoo, William G. Couser, Miriam Alvarado, Richard C. Franklin, Lisa C. Rosenfeld, Andrew C Steer, Bernadette Thomas, Jeyaraj D Pandian, Sarah Wulf, Kathryn G. Andrews, Neuroépidémiologie Tropicale ( NET ), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Institut Génomique, Environnement, Immunité, Santé, Thérapeutique ( GEIST ), Université de Limoges ( UNILIM ) -Université de Limoges ( UNILIM ), Service de Chirurgie Thoracique et Vasculaire - Médecine vasculaire [CHU Limoges], CHU Limoges, Respiratory Epidemiology and Public Health, Imperial College London-Royal Brompton Hospital-National Heart and Lung Institute, Laboratoire Chrono-environnement ( LCE ), Université Bourgogne Franche-Comté ( UBFC ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Franche-Comté ( UFC ), Service des maladies infectieuses et tropicales, Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ) -Hôpital Saint-Jacques, Cisco Systems, CISCO Systems, Inc, Department of dermatology, Milano University-Azienda Ospedaleria Ospedali Riuniti di Bergamo, centre for photomolecular science, Imperial College London, Department of neurology, Miller School of Medicine-University of Miami [Coral Gables], Département Cité des métiers - Cité de la santé - Universcience ( CDM/CDS ), Cité des Sciences et de l'Industrie, Public Health, Cell biology, Cardiothoracic Surgery, Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Imperial College London-Royal Brompton Hospital-National Heart and Lung Institute [UK], Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Hôpital Saint-Jacques, University of Miami [Coral Gables]-University of Miami Leonard M. Miller School of Medicine (UMMSM), and Département Cité des métiers - Cité de la santé - Universcience (CDM/CDS)
Subjects: Male, Pediatrics, MESH : Mortality, MESH : Aged, Poison control, Disease, MESH : Child, Preschool, 030204 cardiovascular system & hematology, Global Health, MESH: Cause of Death, MESH: Aged, 80 and over, 0302 clinical medicine, MESH : Child, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Cause of Death, MESH: Child, MESH : Female, 030212 general & internal medicine, Child, Cause of death, Aged, 80 and over, MESH: Aged, education.field_of_study, MESH: Middle Aged, Mortality rate, MESH: Infant, Newborn, Age Factors, 1. No poverty, MESH : Infant, General Medicine, Middle Aged, MESH : Adult, MESH: Infant, 3. Good health, MESH : World Health, [ SDV.MHEP.MI ] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, MESH: Young Adult, Child, Preschool, Female, Adult, medicine.medical_specialty, Adolescent, MESH : Male, MESH : Sex Factors, Population, MESH : Young Adult, MESH : Infant, Newborn, Young Adult, 03 medical and health sciences, Sex Factors, MESH: Sex Factors, SDG 3 - Good Health and Well-being, MESH : Adolescent, Injury prevention, medicine, Humans, MESH : Middle Aged, Mortality, MESH : Aged, 80 and over, education, Aged, MESH : Cause of Death, MESH: Adolescent, MESH: Age Factors, MESH: Humans, MESH: Mortality, business.industry, MESH: Child, Preschool, MESH : Humans, Infant, Newborn, Infant, MESH: Adult, Verbal autopsy, MESH: Male, Years of potential life lost, MESH : Age Factors, business, MESH: Female, MESH: World Health, Demography
Abstract: International audience; BACKGROUND: Reliable and timely information on the leading causes of death in populations, and how these are changing, is a crucial input into health policy debates. In the Global Burden of Diseases, Injuries, and Risk Factors Study 2010 (GBD 2010), we aimed to estimate annual deaths for the world and 21 regions between 1980 and 2010 for 235 causes, with uncertainty intervals (UIs), separately by age and sex. METHODS: We attempted to identify all available data on causes of death for 187 countries from 1980 to 2010 from vital registration, verbal autopsy, mortality surveillance, censuses, surveys, hospitals, police records, and mortuaries. We assessed data quality for completeness, diagnostic accuracy, missing data, stochastic variations, and probable causes of death. We applied six different modelling strategies to estimate cause-specific mortality trends depending on the strength of the data. For 133 causes and three special aggregates we used the Cause of Death Ensemble model (CODEm) approach, which uses four families of statistical models testing a large set of different models using different permutations of covariates. Model ensembles were developed from these component models. We assessed model performance with rigorous out-of-sample testing of prediction error and the validity of 95% UIs. For 13 causes with low observed numbers of deaths, we developed negative binomial models with plausible covariates. For 27 causes for which death is rare, we modelled the higher level cause in the cause hierarchy of the GBD 2010 and then allocated deaths across component causes proportionately, estimated from all available data in the database. For selected causes (African trypanosomiasis, congenital syphilis, whooping cough, measles, typhoid and parathyroid, leishmaniasis, acute hepatitis E, and HIV/AIDS), we used natural history models based on information on incidence, prevalence, and case-fatality. We separately estimated cause fractions by aetiology for diarrhoea, lower respiratory infections, and meningitis, as well as disaggregations by subcause for chronic kidney disease, maternal disorders, cirrhosis, and liver cancer. For deaths due to collective violence and natural disasters, we used mortality shock regressions. For every cause, we estimated 95% UIs that captured both parameter estimation uncertainty and uncertainty due to model specification where CODEm was used. We constrained cause-specific fractions within every age-sex group to sum to total mortality based on draws from the uncertainty distributions. FINDINGS: In 2010, there were 52*8 million deaths globally. At the most aggregate level, communicable, maternal, neonatal, and nutritional causes were 24*9% of deaths worldwide in 2010, down from 15*9 million (34*1%) of 46*5 million in 1990. This decrease was largely due to decreases in mortality from diarrhoeal disease (from 2*5 to 1*4 million), lower respiratory infections (from 3*4 to 2*8 million), neonatal disorders (from 3*1 to 2*2 million), measles (from 0*63 to 0*13 million), and tetanus (from 0*27 to 0*06 million). Deaths from HIV/AIDS increased from 0*30 million in 1990 to 1*5 million in 2010, reaching a peak of 1*7 million in 2006. Malaria mortality also rose by an estimated 19*9% since 1990 to 1*17 million deaths in 2010. Tuberculosis killed 1*2 million people in 2010. Deaths from non-communicable diseases rose by just under 8 million between 1990 and 2010, accounting for two of every three deaths (34*5 million) worldwide by 2010. 8 million people died from cancer in 2010, 38% more than two decades ago; of these, 1*5 million (19%) were from trachea, bronchus, and lung cancer. Ischaemic heart disease and stroke collectively killed 12*9 million people in 2010, or one in four deaths worldwide, compared with one in five in 1990; 1*3 million deaths were due to diabetes, twice as many as in 1990. The fraction of global deaths due to injuries (5*1 million deaths) was marginally higher in 2010 (9*6%) compared with two decades earlier (8*8%). This was driven by a 46% rise in deaths worldwide due to road traffic accidents (1*3 million in 2010) and a rise in deaths from falls. Ischaemic heart disease, stroke, chronic obstructive pulmonary disease (COPD), lower respiratory infections, lung cancer, and HIV/AIDS were the leading causes of death in 2010. Ischaemic heart disease, lower respiratory infections, stroke, diarrhoeal disease, malaria, and HIV/AIDS were the leading causes of years of life lost due to premature mortality (YLLs) in 2010, similar to what was estimated for 1990, except for HIV/AIDS and preterm birth complications. YLLs from lower respiratory infections and diarrhoea decreased by 45-54% since 1990; ischaemic heart disease and stroke YLLs increased by 17-28%. Regional variations in leading causes of death were substantial. Communicable, maternal, neonatal, and nutritional causes still accounted for 76% of premature mortality in sub-Saharan Africa in 2010. Age standardised death rates from some key disorders rose (HIV/AIDS, Alzheimer's disease, diabetes mellitus, and chronic kidney disease in particular), but for most diseases, death rates fell in the past two decades; including major vascular diseases, COPD, most forms of cancer, liver cirrhosis, and maternal disorders. For other conditions, notably malaria, prostate cancer, and injuries, little change was noted. INTERPRETATION: Population growth, increased average age of the world's population, and largely decreasing age-specific, sex-specific, and cause-specific death rates combine to drive a broad shift from communicable, maternal, neonatal, and nutritional causes towards non-communicable diseases. Nevertheless, communicable, maternal, neonatal, and nutritional causes remain the dominant causes of YLLs in sub-Saharan Africa. Overlaid on this general pattern of the epidemiological transition, marked regional variation exists in many causes, such as interpersonal violence, suicide, liver cancer, diabetes, cirrhosis, Chagas disease, African trypanosomiasis, melanoma, and others. Regional heterogeneity highlights the importance of sound epidemiological assessments of the causes of death on a regular basis. FUNDING: Bill & Melinda Gates Foundation.
Published: 2012
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8. Outcome of Acute Promyelocytic Leukemia (APL) in Children and Adolescents: An Analysis in Two Consecutive Trials of the European APL Group

Author: Xavier Thomas, Christian Recher, Hervé Dombret, Agnès Guerci, Norbert Vey, Bruno Cassinat, André Baruchel, Nadia Idres, Thierry Leblanc, Pierre Fenaux, Christine Chomienne, Miguel A. Sanz, Guy Leverger, Cecile Bally, Lionel Ades, Yves Bertrand, Alain Robert, Jehane Fadlallah, Emmanuel Raffoux, Sciences Po Grenoble - Institut d'études politiques de Grenoble (IEPG), Service d'hématologie-immunologie-oncologie pédiatrique [CHU Trousseau], Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Service d'hématologie biologique, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hôpital Edouard Herriot [CHU - HCL], Hospices Civils de Lyon (HCL), Service de Pédiatrie Hématologique, Hôpital Robert Debré, Unite de Biologie Cellulaire, Hematology (IPC-Marseille), Hématologie -Immunologie -Cibles thérapeutiques, Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Lymphocyte et cancer, IFR105-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Avicenne [AP-HP], Service d'hématologie clinique [Avicenne], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris 13 (UP13)-Hôpital Avicenne [AP-HP]
Subjects: Male, Cancer Research, Pediatrics, Time Factors, medicine.medical_treatment, MESH: Risk Assessment, MESH: Dose-Response Relationship, Drug, law.invention, MESH: Cause of Death, 0302 clinical medicine, Leukemia, Promyelocytic, Acute, Randomized controlled trial, law, MESH: Child, Cause of Death, Antineoplastic Combined Chemotherapy Protocols, Medicine, Cumulative incidence, Child, MESH: Treatment Outcome, Cause of death, MESH: Middle Aged, Age Factors, Middle Aged, Prognosis, 3. Good health, Europe, MESH: Antineoplastic Combined Chemotherapy Protocols, Leukemia, Treatment Outcome, Oncology, MESH: Survival Analysis, Child, Preschool, 030220 oncology & carcinogenesis, Female, MESH: Neoplasm Recurrence, Local, Adult, Acute promyelocytic leukemia, medicine.medical_specialty, Adolescent, [SDV.CAN]Life Sciences [q-bio]/Cancer, Tretinoin, MESH: Drug Administration Schedule, Risk Assessment, MESH: Prognosis, Disease-Free Survival, Drug Administration Schedule, 03 medical and health sciences, Humans, Survival analysis, MESH: Adolescent, MESH: Age Factors, Chemotherapy, MESH: Humans, MESH: Tretinoin, Dose-Response Relationship, Drug, business.industry, MESH: Time Factors, MESH: Child, Preschool, MESH: Adult, medicine.disease, Survival Analysis, MESH: Male, Clinical trial, MESH: Disease-Free Survival, MESH: Europe, Neoplasm Recurrence, Local, business, MESH: Female, MESH: Leukemia, Promyelocytic, Acute, 030215 immunology
Abstract: Purpose Acute promyelocytic leukemia (APL) is rare in children. All-trans-retinoic acid (ATRA) combined with chemotherapy, the reference treatment of APL, is generally considered to produce similar results in children and adults. However, previously published childhood APL studies have generally analyzed all patients age < 18 years as a group, without further dividing according to age. Patients and Methods We compared disease characteristics and outcomes of children (age ≤ 12 years), adolescents (13 to 18 years), and adults (> 18 years) included in two multicenter APL clinical trials (APL 93 and 2000 trials). Results Of the 833 patients age ≤ 60 years included in the two trials, 26 (3%), 58 (7%), and 749 (90%) were children, adolescents, and adults, respectively. Children had significantly higher baseline WBC counts (P < .001). The complete remission (CR) rate (92%, 100%, and 94.5%, respectively) and 5-year cumulative incidence of relapse (CIR; 28%, 20%, and 23%, respectively) did not differ between children, adolescents, and adults, whereas adolescents had significantly better overall survival (OS; 5-year OS, 93.6% v 80.4% in adults and 80.4% in children; P = .03). However, in children age ≤ 4 years, the 5-year CIR was 52%, compared with 17.6% in children age 5 to 12 years (P = .006), although most of the younger children who relapsed experienced durable salvage with autologous or allogeneic stem-cell transplantation. Conclusion Adolescents and children age > 4 years with APL treated with ATRA and chemotherapy have outcomes at least as favorable as those of adults. Younger children seem to experience more relapses and may require reinforcement of first-line treatment.
Published: 2012
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9. Outcomes in severe sepsis and patients with septic shock: Pathogen species and infection sites are not associated with mortality*

Author: Dany Goldgran-Toledano, Adrien Français, Elie Azoulay, Jean-François Timsit, Yohann Dubois, Aurélien Vesim, Bertrand Souweine, Bernard Allaouchiche, Jean-Ralph Zahar, Adrien Descorps-Declere, Christophe Adrie, Maité Garrouste-Orgeas, Aurélien Vesin, Hakim Haouache, Equipe mobile d'infectiologie, CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service Microbiologie-Hygiène Hospitalière, Institut d'oncologie/développement Albert Bonniot de Grenoble (INSERM U823), Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), Epidémiologie pronostique des cancers et affections graves, Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de réanimation chirurgicale [Béclère], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Antoine Béclère [Clamart], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Clinique de réanimation médicale, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-Hôpital Michallon, Laboratoire Microorganismes : Génome et Environnement (LMGE), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Centre National de la Recherche Scientifique (CNRS), Hôpital Delafontaine, Centre Hospitalier de Saint-Denis [Ile-de-France], Service de Réanimation Polyvalente, Centre Hospitalier de Gonesse, Service de Réanimation, Hospices Civils de Lyon (HCL)-Hôpital E. Herriot, Medical ICU, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Service de réanimation médicale et chirurgicale, and Institut National de la Santé et de la Recherche Médicale (INSERM)-EFS-CHU Grenoble-Université Joseph Fourier - Grenoble 1 (UJF)
Subjects: Male, Databases, Factual, MESH: Drug Resistance, Microbial, Drug resistance, MESH: Risk Assessment, Critical Care and Intensive Care Medicine, Severity of Illness Index, MESH: Gram-Positive Bacteria, MESH: Proportional Hazards Models, MESH: Cause of Death, 0302 clinical medicine, Cause of Death, MESH: Gram-Negative Bacteria, Hospital Mortality, Prospective Studies, 030212 general & internal medicine, MESH: Sepsis, MESH: Treatment Outcome, MESH: Aged, Cross Infection, MESH: Microbial Sensitivity Tests, MESH: Middle Aged, Drug Resistance, Microbial, Middle Aged, Prognosis, Shock, Septic, Anti-Bacterial Agents, 3. Good health, Community-Acquired Infections, Survival Rate, Intensive Care Units, Treatment Outcome, MESH: Community-Acquired Infections, Cohort, Female, medicine.symptom, medicine.medical_specialty, Critical Care, MESH: Survival Rate, MESH: Shock, Septic, Microbial Sensitivity Tests, Gram-Positive Bacteria, Risk Assessment, MESH: Multivariate Analysis, MESH: Prognosis, 03 medical and health sciences, Sepsis, MESH: Anti-Bacterial Agents, MESH: Severity of Illness Index, Intensive care, Gram-Negative Bacteria, Severity of illness, medicine, Humans, MESH: Hospital Mortality, MESH: Intensive Care, Intensive care medicine, Survival rate, Aged, Proportional Hazards Models, MESH: Humans, Septic shock, business.industry, Organ dysfunction, MESH: Cross Infection, 030208 emergency & critical care medicine, medicine.disease, MESH: Databases, Factual, MESH: Male, MESH: Prospective Studies, Bacteremia, Multivariate Analysis, MESH: Intensive Care Units, business, MESH: Female, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: International audience; OBJECTIVES: We evaluated the respective influence of the causative pathogen and infection site on hospital mortality from severe sepsis related to community-, hospital-, and intensive care unit-acquired infections. DESIGN: We used a prospective observational cohort 10-yr database. We built a subdistribution hazards model with corrections for competing risks and adjustment for potential confounders including early appropriate antimicrobial therapy. SETTING: Twelve intensive care units. PATIENTS: We included 4,006 first episodes of acquisition-site-specific severe sepsis in 3,588 patients. INTEVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: We included 1562 community-acquired, 1432 hospital-acquired, and 1012 intensive care unit-acquired episodes of severe sepsis. After adjustment, we found no independent associations of the causative organism, multidrug resistance of the causative organism, infection site, or presence of bacteremia with mortality. Early appropriate antimicrobial therapy was consistently associated with better survival in the community-acquired (0.64 [0.51-0.8], p = .0001), hospital-acquired (0.72 [0.58-0.88], p = .0011), and intensive care unit-acquired (0.79 [0.64-0.97], p = .0272) groups. CONCLUSION: The infectious process may not exert as strong a prognostic effect when severity, organ dysfunction and, above all, appropriateness of early antimicrobials are taken into account. Our findings emphasize the importance of developing valid recommendations for early antimicrobial therapy.
Published: 2011
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10. Do different measures of early life socioeconomic circumstances predict adult mortality? Evidence from the British Whitehall II and French GAZEL studies

Author: Aline Dugravot, Mika Kivimäki, Jane E. Ferrie, Marie Zins, Archana Singh-Manoux, Marcel Goldberg, Silvia Stringhini, Martin J. Shipley, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Epidemiology and Public Health, University College of London [London] (UCL), Centre de Gérontologie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Sainte Perine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Kaniewski, Nadine, and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)
Subjects: Male, Gerontology, Epidemiology, 030204 cardiovascular system & hematology, France/epidemiology, MESH: Proportional Hazards Models, MESH: Cause of Death, Cohort Studies, 0302 clinical medicine, MESH: Risk Factors, Risk Factors, Neoplasms, Cause of Death, Medicine, MESH: Neoplasms, 030212 general & internal medicine, MESH: Cohort Studies, Cardiovascular Diseases/mortality, Cause of death, MESH: Aged, MESH: Middle Aged, MESH: Risk, United Kingdom/epidemiology, MESH: Follow-Up Studies, Middle Aged, Early life, 3. Good health, Cardiovascular Diseases, MESH: Great Britain, Female, France, Neoplasms/mortality, Socioeconomic Indicator, Cohort study, Adult, Risk, Social class, Article, MESH: Social Class, 03 medical and health sciences, Humans, Occupations, Socioeconomic status, Aged, Proportional Hazards Models, Cardiovascular mortality, MESH: Occupations, MESH: Humans, Proportional hazards model, business.industry, Public Health, Environmental and Occupational Health, MESH: Cardiovascular Diseases, MESH: Adult, United Kingdom, MESH: Male, MESH: France, Social Class, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, MESH: Female, Follow-Up Studies, Demography
Abstract: International audience; BACKGROUND: Father's occupational position, education and height have all been used to examine the effects of adverse early life socioeconomic circumstances on health, but it remains unknown whether they predict mortality equally well. METHODS: We used pooled data on 18,393 men and 7060 women from the Whitehall II and GAZEL cohorts to examine associations between early life socioeconomic circumstances and all-cause and cause-specific mortality. RESULTS: During the 20-y follow-up period, 1487 participants died. Education had a monotonic association with all mortality outcomes; the age, sex and cohort-adjusted HR for the lowest versus the highest educational group was 1.45 (95% CI 1.24 to 1.69) for all-cause mortality. There was evidence of a U-shaped association between height and all-cause, cancer and cardiovascular mortality robust to adjustment for the other indicators (HR 1.41, 95% CI 1.03 to 1.93 for those shorter than average and HR 1.36, 95% CI 0.98 to 1.88 for those taller than average for cardiovascular mortality). Greater all-cause and cancer mortality was observed in participants whose father's occupational position was manual rather than non-manual (HR 1.11, 95% CI 1.00 to 1.23 for all-cause mortality), but the risks were attenuated after adjusting for education and height. CONCLUSIONS: The association between early life socioeconomic circumstances and mortality depends on the socioeconomic indicator used and the cause of death examined. Height is not a straightforward measure of early life socioeconomic circumstances as taller people do not have a health advantage for all mortality outcomes.
Published: 2010
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11. Lethal Effect of CD3-Specific Antibody in Mice Deficient in TGF-β1 by Uncontrolled Flu-Like Syndrome

Author: Sylvain Perruche, Pin Zhang, Takashi Maruyama, Philippe Saas, Wanjun Chen, Jeffrey A. Bluestone, Saas, Philippe, Mucosal Immunology Unit, National Institute of Dental and Craniofacial Research-National Institutes of Health, Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) (RIGHT), Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS [Bourgogne-Franche-Comté])-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), San Francisco Diabetes Center, University of California (UC), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS [Bourgogne-Franche-Comté]), and University of California
Subjects: MESH: Inflammation, Time Factors, CD3 Complex, MESH: Antigens, CD3, T-Lymphocytes, Apoptosis, MESH: Phagocytes, MESH: Mice, Knockout, MESH: Cause of Death, Mice, MESH: Transforming Growth Factor beta1, 0302 clinical medicine, Cause of Death, Immunology and Allergy, MESH: Animals, MESH: Syndrome, Mice, Knockout, Phagocytes, MESH: Cytokines, 0303 health sciences, biology, Syndrome, 3. Good health, medicine.anatomical_structure, Cytokines, [SDV.IMM]Life Sciences [q-bio]/Immunology, Tumor necrosis factor alpha, medicine.symptom, Antibody, [SDV.IMM] Life Sciences [q-bio]/Immunology, CD3, T cell, Immunology, Inflammation, Antibodies, Article, Transforming Growth Factor beta1, 03 medical and health sciences, In vivo, medicine, Animals, MESH: Mice, 030304 developmental biology, MESH: Antibodies, MESH: Apoptosis, MESH: Time Factors, MESH: T-Lymphocytes, biology.protein, 030215 immunology, Transforming growth factor
Abstract: CD3-specific Ab therapy results in a transient, self-limiting, cytokine-associated, flu-like syndrome in experimental animals and in patients, but the underlying mechanism for this spontaneous resolution remains elusive. By using an in vivo model of CD3-specific Ab-induced flu-like syndrome, we show in this paper that a single injection of sublethal dose of the Ab killed all TGF-β1−/− mice. The death of TGF-β1−/− mice was associated with occurrence of this uncontrolled flu-like syndrome, as demonstrated by a sustained storm of systemic inflammatory TNF and IFN-γ cytokines. We present evidence that deficiency of professional phagocytes to produce TGF-β1 after apoptotic T cell clearance may be responsible, together with hypersensitivity of T cells to both activation and apoptosis, for the uncontrolled inflammation. These findings indicate a key role for TGF-β1 and phagocytes in protecting the recipients from lethal inflammation and resolving the flu-like syndrome after CD3-specific Ab treatment. The study may also provide a novel molecular mechanism explaining the early death in TGF-β1−/− mice.
Published: 2009
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12. Sports-related acute cardiovascular events in a general population: a French prospective study

Author: Ahmed Cherief, François Carré, Laurent Chevalier, Jean-Michel Dindard, Marie-Pierre Vincent, Luc Corneloup, Hervé Douard, Laurent Gencel, Moufid Hajjar, Rachel Ricard, Françoise Sedze, Epidémiologie, santé publique et développement, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR99-ISPED, CHU Bordeaux [Bordeaux], Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: Male, Emergency Medical Services, Epidemiology, 030204 cardiovascular system & hematology, MESH: Risk Assessment, MESH: Cause of Death, 0302 clinical medicine, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, Risk Factors, physical exercise, MESH: Risk Factors, Cause of Death, Medicine, Prospective Studies, MESH: Incidence, Myocardial infarction, Young adult, Prospective cohort study, Cause of death, MESH: Aged, education.field_of_study, MESH: Middle Aged, Incidence, Incidence (epidemiology), Age Factors, Middle Aged, 3. Good health, myocardial infarction, Cardiovascular Diseases, MESH: Young Adult, Acute Disease, MESH: Emergency Medical Services, MESH: Acute Disease, Female, [SDV.IB]Life Sciences [q-bio]/Bioengineering, France, Cardiology and Cardiovascular Medicine, arrhythmias, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, Sports, Adult, medicine.medical_specialty, Adolescent, Physical Exertion, Population, sudden death, Physical exercise, Risk Assessment, Sudden death, MESH: Physical Exertion, Young Adult, 03 medical and health sciences, Age Distribution, Sex Factors, MESH: Sex Factors, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Humans, education, MESH: Age Distribution, Aged, MESH: Adolescent, MESH: Age Factors, MESH: Humans, business.industry, MESH: Cardiovascular Diseases, MESH: Adult, 030229 sport sciences, medicine.disease, MESH: Male, MESH: Prospective Studies, MESH: France, Emergency medicine, Physical therapy, MESH: Sports, business, human activities, MESH: Female
Abstract: International audience; BACKGROUND: The effects of physical exercise on the cardiovascular system are presented as a 'paradox' with beneficial effects and hazards. Most earlier studies were retrospective, were concerned with trained athletes, and focused on sudden death or myocardial infarction (MI). The aim of this study was to prospectively study the incidence and the causes of sports-related acute cardiovascular events in a general population. DESIGN AND METHOD: This 1-year prospective study concerned three regions of the southwest of France. Four hospital medical emergency departments participated in the study, and collected all cases of sports-related acute cardiovascular events. RESULTS: One hundred and twenty-seven sports-related cardiovascular events were collected. The mean age of the participants was 45.5 (14.6) years. Most of the events involved men (81.1%). Thus, global incidence of sports-related acute cardiovascular events was 6.5/100,000 participants/year and 10.8/100,000 men/year and 2.2/100,000 women/year, respectively. Forty sports-related deaths [49.0 (13.9) years old; 38 men], 47 sports-related nonlethal MI [52.8 (10.7) years old; 42 men], and 32 (21 men) sports-related cardiac arrhythmias (21 supraventricular, 10 men) were reported. Sports-related deaths and MI were most often observed in the 35-59-years-old men group (P = 0.01). Running, cycling, and swimming were mainly concerned. CONCLUSION: In the general population studied, the absolute incidence of sport-related acute cardiovascular events comprised 6.5/100,000 participants/year. Sports-related MI and deaths, which were the two main causes of emergency calls, were significantly more frequent in middle-aged men. In all cases, except for sports-related supraventricular arrhythmias, men were significantly more involved than women.
Published: 2009
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13. Incidence and prognostic significance of sustained ventricular tachycardias in heart failure patients implanted with biventricular pacemakers without a back-up defibrillator: results from the prospective, multicentre, Mona Lisa cohort study

Author: Marie Lambiez, Nicolas Delarche, Serge Boveda, Eloi Marijon, D. Pavin, Pascal Defaye, Philippe Chevalier, Alan Bulava, Jobst B. Winter, Jean Paul Albenque, Nicolas Combes, Alexander Teubl, Daniel Gras, Sophie Jacob, Clinique Pasteur et Groupe Rythmologie Stimulation Cardiaque/SFC, Clinique Pasteur [Toulouse], Radiobiologie et épidémiologie (DRPH/SRBE), Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Cardiac Stimulation and Rhythmology, CHU Grenoble, Service de cardiologie et maladies vasculaires, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-CHU Pontchaillou [Rennes], Service de cardiologie, Hôpital Est -Lyon, The study was financed by Guidant., Mona Lisa Study Group, Service de cardiologie et maladies vasculaires [Rennes] = Cardiac, Thoracic, and Vascular Surgery [Rennes], and CHU Pontchaillou [Rennes]
Subjects: Male, Pacemaker, Artificial, medicine.medical_treatment, 030204 cardiovascular system & hematology, MESH: Epidemiologic Methods, Ventricular tachycardia, law.invention, Sudden cardiac death, MESH: Cause of Death, MESH: Aged, 80 and over, 0302 clinical medicine, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, law, Cause of Death, 030212 general & internal medicine, Aged, 80 and over, MESH: Aged, Cardiac resynchronization therapy, MESH: Middle Aged, Incidence, Mortality rate, Cardiac Pacing, Artificial, Middle Aged, Prognosis, MESH: Electrophysiologic Techniques, Cardiac, 3. Good health, MESH: Pacemaker, Artificial, Cardiology, Female, [SDV.IB]Life Sciences [q-bio]/Bioengineering, Electrophysiologic Techniques, Cardiac, Cardiology and Cardiovascular Medicine, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, Cohort study, medicine.medical_specialty, Defibrillation, Heart failure, MESH: Cardiac Pacing, Artificial, MESH: Prognosis, 03 medical and health sciences, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Internal medicine, medicine, Humans, Aged, Electrograms, MESH: Humans, business.industry, MESH: Death, Sudden, Cardiac, medicine.disease, MESH: Male, Death, Sudden, Cardiac, MESH: Heart Failure, Tachycardia, Ventricular, Artificial cardiac pacemaker, MESH: Tachycardia, Ventricular, Epidemiologic Methods, business, MESH: Female
Abstract: International audience; AIMS: The aim of this study was to investigate the 12-month incidence, predictive factors, and prognosis of sustained ventricular tachycardia (VT) in chronic heart failure patients implanted with biventricular pacemakers without a back-up defibrillator (CRT-P), assessed by continuous intracardiac ventricular electrograms. METHODS AND RESULTS: The Mona Lisa study, a prospective, multicentre, cohort study, designed to determine the incidence of sustained VT and its prognostic impact in CRT-P recipients within the year after implant enrolled 198 patients with moderate or severe chronic heart failure, despite optimal pharmacological therapy. An independent committee reviewed the data from all arrhythmic episodes as well as causes of death according to predefined criteria. During a mean follow-up of 9.8 +/- 3.1 months after implantation, 8 patients experienced at least one episode of sustained VT [4.3%; 95% confidence interval (CI), 1.1-7.5] and 21 deaths occurred, giving a 12-month mortality rate of 11.7% (95% CI, 6.4-16.9). The presence of sustained VT was associated with a high risk of sudden cardiac death (SCD) and the lowest 12-month overall survival (P < 0.0001). CONCLUSION: The incidence of sustained VT remains relatively low in the first year after CRT-P implantation, but when present appears closely associated with short-term adverse outcomes, especially SCD. This emphasizes the possible value of remote monitoring to detect high-risk patients for urgent upgrading.
Published: 2009
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14. Changes in Causes of Death Among Adults Infected by HIV Between 2000 and 2005: The 'Mortalité 2000 and 2005' Surveys (ANRS EN19 and Mortavic)

Author: Charlotte, Lewden, Thierry, May, Eric, Rosenthal, Christine, Burty, Fabrice, Bonnet, Dominique, Costagliola, Eric, Jougla, Caroline, Semaille, Philippe, Morlat, Dominique, Salmon, Patrice, Cacoub, Geneviève, Chêne, I, Chossat, Epidémiologie, santé publique et développement, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR99-ISPED, Institut de Santé Publique, d'Epidémiologie et de Développement (ISPED), Université Bordeaux Segalen - Bordeaux 2, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Hôpital L'Archet, Centre Hospitalier Universitaire de Nice (CHU Nice)-Hôpital l'Archet, Epidémiologie Clinique et Traitement de l'Infection à VIH, Université Pierre et Marie Curie - Paris 6 (UPMC)-IFR113-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre d'épidémiologie sur les causes médicales de décès (CépiDc), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Bordeaux [Bordeaux], Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Mouillet, Evelyne, Institut National de la Santé et de la Recherche Médicale (INSERM) - Université Bordeaux Segalen - Bordeaux 2 - IFR99 - ISPED, Hôpital de Brabois, Hôpital de Brabois - CHU Nancy - Université Henri Poincaré - Nancy 1 (UHP), CHU Nice - Hôpital l'Archet, Université Pierre et Marie Curie - Paris 6 (UPMC) - IFR113 - Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris Diderot - Paris 7 (UP7) - Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Cochin [APHP], CHU Pitié-Salpêtrière [APHP], and Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)
Subjects: Male, Disease, MESH: Cause of Death, 0302 clinical medicine, Cause of Death, Neoplasms, Surveys and Questionnaires, [SDV.SPEE] Life Sciences [q-bio]/Public Health and Epidemiology, MESH: Neoplasms, Pharmacology (medical), 030212 general & internal medicine, Sida, Cause of death, 0303 health sciences, MESH: Middle Aged, biology, Liver Diseases, Hepatitis C, Middle Aged, Hepatitis B, 3. Good health, Infectious Diseases, Cardiovascular Diseases, Female, Viral disease, Adult, medicine.medical_specialty, MESH: Liver Diseases, 03 medical and health sciences, Acquired immunodeficiency syndrome (AIDS), Internal medicine, medicine, Humans, MESH: Acquired Immunodeficiency Syndrome, Hepatitis, Acquired Immunodeficiency Syndrome, MESH: Humans, 030306 microbiology, business.industry, MESH: Questionnaires, MESH: Cardiovascular Diseases, MESH: Adult, medicine.disease, biology.organism_classification, MESH: Male, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Immunology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, MESH: Female
Abstract: International audience; BACKGROUND: The multicenter national Mortalité 2005 survey aimed at describing the distribution of causes of death among HIV-infected adults in France in 2005 and its changes as compared with 2000. METHODS: Physicians involved in the management of HIV infection notified deaths and documented the causes using a standardized questionnaire similar to the previous survey performed in 2000. RESULTS: Overall, 1042 deaths were notified in 2005 (vs 964 in 2000): with median age, 46 years (vs 41 years); men, 76%; and median last CD4 cell count, 161/mm (vs 94). The proportion of underlying causes of death due to AIDS decreased (36% in 2005 vs 47% in 2000), and the proportion of cancer not related to AIDS or hepatitis (17% vs 11%), liver related disease (15% vs 13%: hepatitis C, 11%, and hepatitis B, 2%), cardiovascular disease (8% vs 7%), or suicide (5% vs 4%) increased. Among the 375 AIDS-related deaths, the most frequent event was non-Hodgkin lymphoma (28%). Among cancers not related to AIDS or hepatitis, the most frequent localizations were lung (31%) and digestive tract (14%). Among the 154 liver-related deaths, 24% were due to hepatocarcinoma. CONCLUSIONS: The heterogeneity of causes of death among HIV-infected adults was confirmed and intensified in 2005, with 3 causes following AIDS: cancers and liver-related and cardiovascular diseases.
Published: 2008
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15. Evaluation of the Incremental Prognostic Utility of Increasingly Complex Testing in Chronic Heart FailureCLINICAL PERSPECTIVE

Author: Ahmad, Tariq, O'Brien, Emily, Schulte, Phillip, Stevens, Susanna, Fiuzat, Mona, Kitzman, Dalane, Adams, Kirkwood, Kraus, William, Piña, Ileana, Donahue, Mark, Zannad, Faiez, Whellan, David, O'Connor, Christopher, Felker, G Michael, Yale University School of Medicine, Duke Clinical Research Institute (DCRI), Duke University [Durham], Duke University Medical Center, Wake Forest University, University of North Carolina [Chapel Hill] (UNC), University of North Carolina System (UNC), Montefiore Medical Center, Service de Cardiologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Thomas Jefferson University, and Inova Heart and Vascular Institute
Subjects: MESH: Diagnostic Techniques, Cardiovascular, brain, heart failure, MESH: Hospitalization, MESH: Risk Assessment, MESH: Stroke Volume, MESH: Prognosis, MESH: Ventricular Function, Left, MESH: Cause of Death, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, MESH: Risk Factors, echocardiography, MESH: Natriuretic Peptide, Brain, MESH: Surveys and Questionnaires, MESH: Peptide Fragments, MESH: Aged, MESH: Humans, MESH: Middle Aged, natriuretic peptide, MESH: Chronic Disease, MESH: Quality of Life, MESH: Male, MESH: Predictive Value of Tests, quality of life, MESH: Heart Failure, MESH: Biomarkers, MESH: Echocardiography, MESH: Exercise Test, MESH: Female, hospitalization
Abstract: International audience; BACKGROUND:Current heart failure (HF) risk prediction models do not consider how individual patient assessments occur in incremental steps; furthermore, each additional diagnostic evaluation may add cost, complexity, and potential morbidity.METHODS AND RESULTS:Using a cohort of well-treated ambulatory HF patients with reduced ejection fraction who had complete clinical, laboratory, health-related quality of life, imaging, and exercise testing data, we estimated incremental prognostic information provided by 5 assessment categories, performing an additional analysis on those with available N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels. We compared the incremental value of each additional assessment (quality of life screen, laboratory testing, echocardiography, and exercise testing) to baseline clinical assessment for predicting clinical outcomes (all-cause mortality, all-cause mortality/hospitalization, and cardiovascular death/HF hospitalizations), gauging incremental improvements in prognostic ability with more information using area under the curve and reclassification improvement (net reclassification index), with and without NT-proBNP availability. Of 2331 participants, 1631 patients had complete clinical data; of these, 1023 had baseline NT-proBNP. For prediction of all-cause mortality, models with incremental assessments sans NT-proBNP showed improvements in C-indices (0.72 [clinical model alone]-0.77 [complete model]). Compared with baseline clinical assessment alone, net reclassification index improved from 0.035 (w/laboratory data) to 0.085 (complete model). These improvements were significantly attenuated for models in the subset with measured NT-proBNP data (c-indices: 0.80 [w/laboratory data]-0.81 [full model]); net reclassification index improvements were similarly marginal (0.091→0.096); prediction of other clinical outcomes had similar findings.CONCLUSIONS:In chronic HF patients with reduced ejection fraction, the marginal benefit of complex prognostic evaluations should be weighed against potential patient discomfort and cost escalation.CLINICAL TRIAL REGISTRATION:URL: http://www.clinicaltrials.gov. Unique identifier: NCT00047437.
Published: 2015
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16. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013

Author: 2013 Mortality and Causes of Death Collaborators, GBD, Aboyans, Victor, Grelier, Elisabeth, Service de Chirurgie Thoracique et Vasculaire - Médecine vasculaire [CHU Limoges], CHU Limoges, Neuroépidémiologie Tropicale (NET), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), and Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: MESH: Adolescent, MESH: Aged, MESH: Humans, MESH: Middle Aged, MESH: Mortality, MESH: Infant, Newborn, MESH: Sex Distribution, MESH: Child, Preschool, MESH: Child Mortality, MESH: Adult, MESH: Global Health, MESH: Infant, MESH: Databases, Factual, MESH: Life Tables, MESH: Male, MESH: Cause of Death, MESH: Aged, 80 and over, MESH: Young Adult, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Child, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Life Expectancy, MESH: Female, MESH: Models, Statistical
Abstract: International audience; Up-to-date evidence on levels and trends for age-sex-specific all-cause and cause-specific mortality is essential for the formation of global, regional, and national health policies. In the Global Burden of Disease Study 2013 (GBD 2013) we estimated yearly deaths for 188 countries between 1990, and 2013. We used the results to assess whether there is epidemiological convergence across countries. We estimated age-sex-specific all-cause mortality using the GBD 2010 methods with some refinements to improve accuracy applied to an updated database of vital registration, survey, and census data. We generally estimated cause of death as in the GBD 2010. Key improvements included the addition of more recent vital registration data for 72 countries, an updated verbal autopsy literature review, two new and detailed data systems for China, and more detail for Mexico, UK, Turkey, and Russia. We improved statistical models for garbage code redistribution. We used six different modelling strategies across the 240 causes; cause of death ensemble modelling (CODEm) was the dominant strategy for causes with sufficient information. Trends for Alzheimer's disease and other dementias were informed by meta-regression of prevalence studies. For pathogen-specific causes of diarrhoea and lower respiratory infections we used a counterfactual approach. We computed two measures of convergence (inequality) across countries: the average relative difference across all pairs of countries (Gini coefficient) and the average absolute difference across countries. To summarise broad findings, we used multiple decrement life-tables to decompose probabilities of death from birth to exact age 15 years, from exact age 15 years to exact age 50 years, and from exact age 50 years to exact age 75 years, and life expectancy at birth into major causes. For all quantities reported, we computed 95% uncertainty intervals (UIs). We constrained cause-specific fractions within each age-sex-country-year group to sum to all-cause mortality based on draws from the uncertainty distributions. Global life expectancy for both sexes increased from 65.3 years (UI 65.0-65.6) in 1990, to 71.5 years (UI 71.0-71.9) in 2013, while the number of deaths increased from 47.5 million (UI 46.8-48.2) to 54.9 million (UI 53.6-56.3) over the same interval. Global progress masked variation by age and sex: for children, average absolute differences between countries decreased but relative differences increased. For women aged 25-39 years and older than 75 years and for men aged 20-49 years and 65 years and older, both absolute and relative differences increased. Decomposition of global and regional life expectancy showed the prominent role of reductions in age-standardised death rates for cardiovascular diseases and cancers in high-income regions, and reductions in child deaths from diarrhoea, lower respiratory infections, and neonatal causes in low-income regions. HIV/AIDS reduced life expectancy in southern sub-Saharan Africa. For most communicable causes of death both numbers of deaths and age-standardised death rates fell whereas for most non-communicable causes, demographic shifts have increased numbers of deaths but decreased age-standardised death rates. Global deaths from injury increased by 10.7%, from 4.3 million deaths in 1990 to 4.8 million in 2013; but age-standardised rates declined over the same period by 21%. For some causes of more than 100,000 deaths per year in 2013, age-standardised death rates increased between 1990 and 2013, including HIV/AIDS, pancreatic cancer, atrial fibrillation and flutter, drug use disorders, diabetes, chronic kidney disease, and sickle-cell anaemias. Diarrhoeal diseases, lower respiratory infections, neonatal causes, and malaria are still in the top five causes of death in children younger than 5 years. The most important pathogens are rotavirus for diarrhoea and pneumococcus for lower respiratory infections. Country-specific probabilities of death over three phases of life were substantially varied between and within regions. For most countries, the general pattern of reductions in age-sex specific mortality has been associated with a progressive shift towards a larger share of the remaining deaths caused by non-communicable disease and injuries. Assessing epidemiological convergence across countries depends on whether an absolute or relative measure of inequality is used. Nevertheless, age-standardised death rates for seven substantial causes are increasing, suggesting the potential for reversals in some countries. Important gaps exist in the empirical data for cause of death estimates for some countries; for example, no national data for India are available for the past decade. Bill & Melinda Gates Foundation.
Published: 2015

17. Description of the SAGhE Cohort: A Large European Study of Mortality and Cancer Incidence Risks after Childhood Treatment with Recombinant Growth Hormone

Author: Swerdlow , Anthony, Cooke , Rosie, Albertsson-Wikland , Kerstin, Borgström , Birgit, Butler , Gary, Cianfarani , Stefano, Clayton , Peter, Coste , Joël, Deodati , Annalisa, Ecosse , Emmanuel, Gausche , Ruth, Giacomozzi , Claudio, Kiess , Wieland, Hokken-Koelega , Anita, Kuehni , Claudia, Landier , Fabienne, Maes , Marc, Mullis , Primus-E, Pfaffle , Roland, Sävendahl , Lars, Sommer , Grit, Thomas , Muriel, Tollerfield , Sally, Zandwijken , Gladys, Carel , Jean-Claude, UCL - SSS/IREC/PEDI - Pôle de Pédiatrie, UCL - (SLuc) Unité d'endocrinologie pédiatrique, Institute of Cancer Research - ICR [London, U.K.], Sahlgrenska Academy at University of Gothenburg [Göteborg], Karolinska Institutet [Stockholm], Institute of Child Health [London], University College of London [London] (UCL), University College London Hospitals (UCLH), IRCCS Ospedale Pediatrico Bambino Gesù [Roma], Royal Manchester Children's Hospital, University of Manchester [Manchester], Unité d’Epidémiologie et de Biostatistiques [APHP Cochin-Broca-Hôtel Dieu], AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Maladies chroniques, santé perçue, et processus d'adaptation (APEMAC), Université Paris Descartes - Paris 5 (UPD5)-Université de Lorraine (UL), Universität Leipzig [Leipzig], Erasmus University Medical Center [Rotterdam] (Erasmus MC), Sophia Children's Hospital, Institute of Social and Preventive Medicine [Bern] (ISPM), Universität Bern [Bern], Centre de Référence des Maladies Endocriniennes Rares de la Croissance [APHP Robert Debré], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Robert Debré-Université Paris Diderot - Paris 7 (UPD7), Service d'endocrinologie diabétologie pédiatrique [CHU Debré], AP-HP Hôpital universitaire Robert-Debré [Paris], Université Paris Diderot - Paris 7 (UPD7), Centre d'Investigation Clinique - Epidemiologie Clinique/essais Cliniques Hopital Robert Debre, Institut National de la Santé et de la Recherche Médicale (INSERM), Cliniques universitaires St Luc [Bruxelles], Inselspital Bern, Belgian Study Group for Pediatric Endocrinology (BSGPE), Universitair Ziekenhuis Brussel, Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Robert Debré-Université Paris Diderot - Paris 7 (UPD7), University College of London [London] ( UCL ), University College London Hospitals ( UCLH ), Maladies chroniques, santé perçue, et processus d'adaptation. Approches épidémiologiques et psychologiques. ( APEMAC - EA 4360 ), Université Paris Descartes - Paris 5 ( UPD5 ) -Université de Lorraine ( UL ), Erasmus Medical Center / Dutch Growth Research Foundation, Erasmus University Medical Center [Rotterdam], Institute of Social and Preventive Medicine [Bern] ( ISPM ), Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Robert Debré-Université Paris Diderot - Paris 7 ( UPD7 ), Université Paris Diderot - Paris 7 ( UPD7 ), Institut National de la Santé et de la Recherche Médicale ( INSERM ), Belgian Study Group for Pediatric Endocrinology ( BSGPE ), and Pediatrics
Subjects: Male, MESH : Risk, MESH : Child, Preschool, Cohort Studies, MESH: Cause of Death, MESH: Recombinant Proteins, MESH : Child, Cause of Death, Neoplasms, MESH: Child, MESH: Human Growth Hormone, MESH : Female, MESH: Neoplasms, MESH: Incidence, Child, MESH: Cohort Studies, Growth Disorders, Cancer, MESH: Risk, Human Growth Hormone, Incidence, MESH: Infant, Newborn, Cohort, MESH : Infant, [ SDV.SPEE ] Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Follow-Up Studies, MESH: Growth Disorders, MESH: Infant, MESH : Incidence, Recombinant Proteins, Europe, MESH: Young Adult, Child, Preschool, Female, Risk, Adolescent, MESH : Recombinant Proteins, MESH : Male, MESH : Europe, MESH : Young Adult, MESH : Cohort Studies, 610 Medicine & health, MESH : Infant, Newborn, Young Adult, SDG 3 - Good Health and Well-being, 360 Social problems & social services, MESH : Adolescent, Humans, MESH : Growth Disorders, MESH : Human Growth Hormone, Mortality, Growth hormone, MESH : Cause of Death, Settore MED/38 - Pediatria Generale e Specialistica, MESH: Adolescent, Original Paper, MESH: Humans, MESH : Humans, MESH: Child, Preschool, Infant, Newborn, Infant, MESH : Follow-Up Studies, MESH : Neoplasms, MESH: Male, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Europe, MESH: Female, Follow-Up Studies
Abstract: International audience; BACKGROUND:The long-term safety of growth hormone treatment is uncertain. Raised risks of death and certain cancers have been reported inconsistently, based on limited data or short-term follow-up by pharmaceutical companies.PATIENTS AND METHODS:The SAGhE (Safety and Appropriateness of Growth Hormone Treatments in Europe) study assembled cohorts of patients treated in childhood with recombinant human growth hormone (r-hGH) in 8 European countries since the first use of this treatment in 1984 and followed them for cause-specific mortality and cancer incidence. Expected rates were obtained from national and local general population data. The cohort consisted of 24,232 patients, most commonly treated for isolated growth failure (53%), Turner syndrome (13%) and growth hormone deficiency linked to neoplasia (12%). This paper describes in detail the study design, methods and data collection and discusses the strengths, biases and weaknesses consequent on this.CONCLUSION:The SAGhE cohort is the largest and longest follow-up cohort study of growth hormone-treated patients with follow-up and analysis independent of industry. It forms a major resource for investigating cancer and mortality risks in r-hGH patients. The interpretation of SAGhE results, however, will need to take account of the methods of cohort assembly and follow-up in each country.
Published: 2015
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18. Dialyzer membrane permeability and survival in hemodialysis patients

Author: Chauveau, Philippe, Nguyen, Hiep, Combe, Christian, Chêne, Geneviève, Azar, Raymond, Cano, Noël, Canaud, Bernard, Fouque, Denis, Laville, Maurice, Leverve, Xavier, Roth, Hubert, Aparicio, Michel, Nutrition In Dialysis, French Study Group For, Hamant, Sarah, Département de Néphrologie, Université Bordeaux Segalen - Bordeaux 2, Institut de Santé Publique, d'Epidémiologie et de Développement (ISPED), Service de Médecine Interne B, Centre Hospitalier Dunkerque, Service d'Hépatogastroentérologie et Nutrition, Clinique Résidence du Parc, Service de Néphrologie, Dialyse et Soins Intensifs, Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Lapeyronie, Service de néphrologie, Hospices Civils de Lyon (HCL)-Hôpital Edouard Herriot [CHU - HCL], Hospices Civils de Lyon (HCL), Bioénergétique fondamentale et appliquée, and Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: Male, Nephrology, Time Factors, medicine.medical_treatment, 030232 urology & nephrology, MESH: Comorbidity, Comorbidity, 030204 cardiovascular system & hematology, Body Mass Index, Dialysis tubing, MESH: Proportional Hazards Models, MESH: Cause of Death, chemistry.chemical_compound, MESH: Bicarbonates, MESH: Cholesterol, 0302 clinical medicine, Cause of Death, Neoplasms, Prealbumin, Urea, Medicine, Diabetic Nephropathies, Life Tables, MESH: Neoplasms, MESH: Renal Dialysis, Prospective Studies, MESH: Aged, 2. Zero hunger, Dialysis adequacy, MESH: Middle Aged, MESH: Follow-Up Studies, Middle Aged, MESH: Life Tables, MESH: Predictive Value of Tests, 3. Good health, Cholesterol, Cardiovascular Diseases, MESH: Kidney Failure, Chronic, Creatinine, MESH: Permeability, MESH: Survival Analysis, Body Composition, Female, Hemodialysis, MESH: Membranes, Artificial, MESH: Infection, medicine.medical_specialty, MESH: Diabetic Nephropathies, Membrane permeability, Urology, MESH: Serum Albumin, MESH: Creatinine, Infections, Protein-Energy Malnutrition, Permeability, MESH: Body Mass Index, 03 medical and health sciences, Predictive Value of Tests, Renal Dialysis, MESH: Prealbumin, Internal medicine, Humans, MESH: Erythropoietin, Erythropoietin, Survival rate, Serum Albumin, MESH: Urea, Aged, Proportional Hazards Models, MESH: Humans, business.industry, MESH: Time Factors, MESH: Cardiovascular Diseases, Membranes, Artificial, MESH: Body Composition, Survival Analysis, MESH: Male, MESH: Prospective Studies, MESH: Protein-Energy Malnutrition, Surgery, Bicarbonates, chemistry, Lean body mass, Kidney Failure, Chronic, business, MESH: Female, Follow-Up Studies
Abstract: International audience; BACKGROUND: We previously showed that nutritional protein concentrations were predictive of outcome, whereas variables reflecting body composition and dialysis dose were not, in a 30-month prospective follow-up of 1,610 hemodialysis patients. Information on dialysis membrane and erythropoietin use had to be evaluated in an additional follow-up. METHODS: A subset of 650 patients from the initial cohort of 1,610 was analyzed for survival in a 2-year extension of follow-up. Detailed data were collected: demographics; cause of renal failure; time on dialysis therapy; type of membrane; erythropoietin treatment; body mass index (BMI); predialysis albumin, prealbumin, and bicarbonate levels; and outcome. Normalized protein catabolic rate (nPCR), dialysis adequacy, and lean body mass were computed from predialysis and postdialysis urea and creatinine values. RESULTS: Patient characteristics were age of 61 +/- 16 years, 58% men, BMI of 22.7 +/- 4.4 kg/m2 , time on dialysis therapy of 102 +/- 73 months, and 8.8% had diabetes. Dialysis parameters were duration of 247 +/- 31 minutes, Kt/V of 1.4 +/- 0.3, and nPCR of 1.2 +/- 0.3 g/kg/d. Albumin level was 3.73 +/- 0.53 g/dL (37.3 +/- 5.3 g/L), and prealbumin level was 31 +/- 8 mg/dL. The survival rate was 78.7% after 2 years. Survival was influenced by age, presence of diabetes, use of high-flux membrane, and serum albumin level, but not other variables, including Kt/V and prealbumin level. Two-year variations in values for urea, creatinine, and weight were predictive of survival in univariate, but not multivariate, analyses. CONCLUSION: In patients on dialysis therapy for a long period, better survival was observed when high-flux dialysis membranes were used.
Published: 2005
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19. Long-term mortality in HIV-positive individuals virally suppressed for >3 years with incomplete CD4 recovery

Author: Engsig, F. N., Zangerle, R., Katsarou, O., Dabis, F., Reiss, P., Gill, J., Porter, K., Sabin, C., Riordan, A., Fatkenheuer, G., Gutierrez, F., Raffi, F., Kirk, O., Mary-Krause, M., Stephan, C., de Olalla, P. G., Guest, J., Samji, H., Castagna, A., d'Arminio Monforte, A., Skaletz-Rorowski, A., Ramos, J., Lapadula, G., Mussini, C., Force, L., Meyer, L., Lampe, F., Boufassa, F., Bucher, H. C., De Wit, S., Burkholder, G. A., Teira, R., Justice, A. C., Sterling, T. R., M. Crane, H., Gerstoft, J., Grarup, J., May, M., Chene, G., Ingle, S. M., Sterne, J., Obel, N., Burkholder, G., Justice, A., R Sterling, T., Crane, H. M., Boulle, A., Brodt, H.-R., Casabona, J., Cavassini, M., Costagliola, D., D'Arminio Monforte, A., del Amo, J., Van Sighem, A., Hans-Ulrich Haerry, D., Hogg, R., Mocroft, A., Kitahata, M., Saag, M., Williams, M., Ingle, S., Touloumi, G., Warszawski, J., Krause, M. M., Ghosn, J., Leport, C., Wit, F., Prins, M., Gibb, D., Del Amo, J., Thorne, C., Perez-Hoyos, S., Hamouda, O., Gussenheimer-Bartmeyer, B., Noguera-Julian, A., Antinori, A., Brockmeyer, N., Battegay, M., Rauch, A., Tookey, P., Miro, J. M., de Wit, S., Goetghebuer, T., Torti, C., Garrido, M., Judd, A., Conejo, P. R., Haerry, D., Weller, I., d'Arminio-Monforte, A., Colin, C., Schwimmer, C., Termote, M., Kjaer, J., Campbell, M., Raben, D., Bohlius, J., Bouteloup, V., Bucher, H., Cozzi-Lepri, A., Dorrucci, M., Egger, M., Engsig, F., Furrer, H., Lambotte, O., Lewden, C., Lodi, S., Lodwick, R., Matheron, S., Miro, J., Monge, S., Nakagawa, F., Paredes, R., Phillips, A., Puoti, M., Reekie, J., Scherrer, A., Smit, C., Thiebaut, R., Wittkop, L., 2nd Blood Transfusion Center and Hemophilia Center, 'Laiko' General Hospital, Epidémiologie et Biostatistique [Bordeaux], Université Bordeaux Segalen - Bordeaux 2-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Structures et propriétés d'architectures moléculaire (SPRAM - UMR 5819), Institut Nanosciences et Cryogénie (INAC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS), Observatoire des Micro et Nano Technologies (OMNT - UMS 2920), Laboratoire d'Electronique et des Technologies de l'Information (CEA-LETI), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA)-Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS), Southern Alberta Clinic, Research Department of Infection and Population Health [London], University College of London [London] (UCL), Equipe Perception et design sonores, Sciences et Technologies de la Musique et du Son (STMS), Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS), Equipe Interactions musicales temps-réel, Maladies infectieuses et tropicales, Université Pierre et Marie Curie - Paris 6 (UPMC), Institute of Biology, Neuchatel, Université de Neuchâtel (UNINE), School of Psychology, St Andrews, University of St Andrews [Scotland], Infectious Diseases, San Raffaele Scientific Institute, EA 4100, Histoire culturelle et sociale de l'art (HiCSA), Université Panthéon-Sorbonne (UP1)-Université Panthéon-Sorbonne (UP1), Laboratory of Inorganic Chemistry, Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology in Zürich [Zürich] (ETH Zürich), Princeton University, Immuno-Rhumatologie Moléculaire, Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Population Sciences, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Paläontologisches Institut und Museum, Universität Zürich [Zürich] (UZH), Laboratory, GD Deventer, Rigshospitalet [Copenhagen], Department of Social Medicine, University of Bristol [Bristol], Department of Infectious Diseases, Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information (CEA-LETI), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), School of Psychology and Neuroscience [University of St. Andrews], Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris 1 Panthéon-Sorbonne (UP1), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Universität Zürich [Zürich] = University of Zurich (UZH), Royal GD [Deventer], Copenhagen University Hospital, Copenhagen University Hospital-Copenhagen University Hospital, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Engsig, F. N., Zangerle, R., Katsarou, O., Dabis, F., Reiss, P., Gill, J., Porter, K., Sabin, C., Riordan, A., Fatkenheuer, G., Gutierrez, F., Raffi, F., Kirk, O., Mary-Krause, M., Stephan, C., De Olalla, P. G., Guest, J., Samji, H., Castagna, A., D'arminio Monforte, A., Skaletz-Rorowski, A., Ramos, J., Lapadula, G., Mussini, C., Force, L., Meyer, L., Lampe, F., Boufassa, F., Bucher, H. C., De Wit, S., Burkholder, G. A., Teira, R., Justice, A. C., Sterling, T. R., M. Crane, H., Gerstoft, J., Grarup, J., May, M., Chene, G., Ingle, S. M., Sterne, J., Obel, N., Engsig, F, Zangerle, R, Katsarou, O, Dabis, F, Reiss, P, Gill, J, Porter, K, Sabin, C, Riordan, A, Fatkenheuer, G, Gutierrez, F, Raffi, F, Kirk, O, Mary-Krause, M, Stephan, C, De Olalla, P, Guest, J, Samji, H, Castagna, A, D'arminio Monforte, A, Skaletz-Rorowski, A, Ramos, J, Lapadula, G, Mussini, C, Force, L, Meyer, L, Lampe, F, Boufassa, F, Bucher, H, De Wit, S, Burkholder, G, Teira, R, Justice, A, Sterling, T, M. Crane, H, Gerstoft, J, Grarup, J, May, M, Chene, G, Ingle, S, Sterne, J, Obel, N, AII - Amsterdam institute for Infection and Immunity, APH - Amsterdam Public Health, Global Health, and Infectious diseases
Subjects: Male, Oncology, MESH: CD4 Lymphocyte Count, [SDV]Life Sciences [q-bio], HIV Infections, MESH: Logistic Models, Cohort Studies, MESH: Cause of Death, 0302 clinical medicine, Risk Factors, MESH: Risk Factors, Cause of Death, Medicine, HIV Infection, 030212 general & internal medicine, MESH: Anti-HIV Agents, MESH: Cohort Studies, Immunodeficiency, Cause of death, 0303 health sciences, MESH: Middle Aged, Hazard ratio, MESH: HIV Infections, Middle Aged, Viral Load, 3. Good health, Infectious Diseases, MESH: Substance-Related Disorders, HIV/AIDS, Female, MESH: Viral Load, Viral load, MESH: Heterosexuality, Human, Adult, Microbiology (medical), Cart, medicine.medical_specialty, Logistic Model, Anti-HIV Agents, Substance-Related Disorders, 03 medical and health sciences, Acquired immunodeficiency syndrome (AIDS), Internal medicine, Humans, sustained viral suppression, Heterosexuality, 030304 developmental biology, MESH: Humans, business.industry, Proportional hazards model, Risk Factor, Anti-HIV Agent, HIV, MESH: Adult, Substance-Related Disorder, medicine.disease, mortality, CD4 cell recovery, Confidence interval, MESH: Male, CD4 Lymphocyte Count, Logistic Models, Immunology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Cohort Studie, business, MESH: Female
Abstract: Background. Some human immunodeficiency virus (HIV)-infected individuals initiating combination antiretroviral therapy (cART) with low CD4 counts achieve viral suppression but not CD4 cell recovery. We aimed to identify (1) risk factors for failure to achieve CD4 count >200 cells/μL after 3 years of sustained viral suppression and (2) the association of the achieved CD4 count with subsequent mortality.Methods. We included treated HIV-infected adults from 2 large international HIV cohorts, who had viral suppression (≤500 HIV type 1 RNA copies/mL) for >3 years with CD4 count ≤200 cells/μL at start of the suppressed period. Logistic regression was used to identify risk factors for incomplete CD4 recovery (≤200 cells/μL) and Cox regression to identify associations with mortality.Results. Of 5550 eligible individuals, 835 (15%) did not reach a CD4 count >200 cells/μL after 3 years of suppression. Increasing age, lower initial CD4 count, male heterosexual and injection drug use transmission, cART initiation after 1998, and longer time from initiation of cART to start of the virally suppressed period were risk factors for not achieving a CD4 count >200 cells/μL. Individuals with CD4 ≤200 cells/μL after 3 years of viral suppression had substantially increased mortality (adjusted hazard ratio, 2.60; 95% confidence interval, 1.86-3.61) compared with those who achieved CD4 count >200 cells/μL. The increased mortality was seen across different patient groups and for all causes of death.Conclusions. Virally suppressed HIV-positive individuals on cART who do not achieve a CD4 count >200 cells/μL have substantially increased long-term mortality. © The Author 2014.
Published: 2014

20. At-risk drinking is independently associated with ICU and one-year mortality in critically ill nontrauma patients*

Author: P. Fillâtre, Jean Marc Tadié, Elise Sauvadet, Julien Letheulle, Pierre Bouju, Yves Le Tulzo, Fabrice Uhel, Arnaud Gacouin, Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: Male, health care facilities, manpower, and services, Alcohol abuse, 030204 cardiovascular system & hematology, Critical Care and Intensive Care Medicine, outcomes, intensive care unit, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, MESH: Length of Stay, law.invention, survival analysis, Hospitals, University, MESH: Cause of Death, 0302 clinical medicine, cohort studies, Risk Factors, law, MESH: Risk Factors, Cause of Death, Prospective Studies, 030212 general & internal medicine, MESH: APACHE, Prospective cohort study, APACHE, Cause of death, MESH: Aged, education.field_of_study, MESH: Middle Aged, Hazard ratio, Age Factors, Middle Aged, Intensive care unit, 3. Good health, Alcoholism, Intensive Care Units, at-risk drinking, MESH: Survival Analysis, MESH: Critical Illness, Female, Cohort study, medicine.medical_specialty, Critical Illness, Population, 03 medical and health sciences, Sex Factors, MESH: Sex Factors, MESH: Alcoholism, medicine, Humans, Intensive care medicine, education, Aged, MESH: Age Factors, MESH: Hospitals, University, MESH: Humans, business.industry, Odds ratio, Length of Stay, medicine.disease, mortality, MESH: Male, MESH: Prospective Studies, Emergency medicine, MESH: Intensive Care Units, business, MESH: Female
Abstract: International audience; OBJECTIVES: The impact of at-risk drinking on the outcomes of nontrauma patients is not well characterized. The aim of this study was to determine whether at-risk drinking is independently associated with the survival of nontrauma patients in an ICU and within 1 year following ICU discharge. DESIGN: Observational cohort study. SETTING: A 21-bed mixed ICU in a university hospital. PATIENTS: A total of 662 patients who experienced an ICU stay of 3 days or more and for whom alcohol consumption could be assessed. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: ICU-related variables were collected prospectively, and a 1-year follow-up was determined retrospectively. Analyses were adjusted based on prognostic determinants of short- and long-term outcomes, as previously described in ICU patients and alcohol abusers. Two hundred and eight patients (33%) were identified as at-risk drinkers according to the National Institute on Alcohol Abuse and Alcoholism criteria. Additionally, 111 patients (17%) died in the ICU, and 97 (15%) died after ICU discharge. From the ICU admission until the end of the 1-year follow-up period, the at-risk drinkers exhibited poorer survival than the non-at-risk drinkers (p = 0.0004, as determined by the log-rank test). More specifically, 50 at-risk drinkers (24%) versus 61 non-at-risk drinkers (13%) died in the ICU (p = 0.0009 for the comparison). After adjustment, at-risk drinking remained independently associated with mortality in the ICU (adjusted odds ratio of 1.83; 95% CI of 1.16-2.89; p = 0.01) and with mortality within the year following ICU discharge (adjusted hazard ratio of 1.70; 95% CI of 1.15-2.52; p = 0.008). The causes of death in the at-risk and non-at-risk drinkers were similar. CONCLUSIONS: In this population of critically ill nontrauma patients, at-risk drinking was independently associated with death in the ICU and within the year following ICU discharge.
Published: 2014
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21. Survival in people with type 2 diabetes as a function of HbA1c

Author: Dominique Simon, Beverley Balkau, De Lauzon-Guillain, Blandine, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Diabétologie [CHU Pitié-Salpétrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), and Service de diabétologie [CHU Pitié-Salpétrière]
Subjects: MESH: Hypoglycemia, media_common.quotation_subject, MESH: Insulin, Type 2 diabetes, 030204 cardiovascular system & hematology, Bioinformatics, MESH: Cause of Death, 03 medical and health sciences, 0302 clinical medicine, Text mining, MESH: Hypoglycemic Agents, Medicine, 030212 general & internal medicine, Function (engineering), ComputingMilieux_MISCELLANEOUS, MESH: Treatment Outcome, media_common, MESH: Middle Aged, MESH: Humans, business.industry, MESH: Biological Markers, General Medicine, medicine.disease, MESH: Male, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Hemoglobin A, Glycosylated, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, MESH: Female, MESH: Diabetes Mellitus, Type 2
Abstract: International audience; no Abstract available
Published: 2010
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22. A time series study on the effects of heat on mortality and evaluation of heterogeneity into European and Eastern-Southern Mediterranean cities: results of EU CIRCE project

Author: Francesca De' Donato, Tanja Wolf, Xavier Basagaña, Manuela De Sario, Klea Katsouyanni, Antonis Analitis, Michela Leone, Bettina Menne, Paola Michelozzi, Zeynep Dörtbudak, Elsa Casimiro, Daniela D’Ippoliti, Chava Peretz, Carmen Iñiguez, Afif Ben Salah, Dörbudak, Zeynep, Leone, Michela, D'Ippoliti, Daniela, De Sario, Manuela, Analitis, Antonis, Menne, Bettina, Katsouyanni, Klea, de'Donato, Francesca K., Basagana, Xavier, Ben Salah, Afif, Casimiro, Elsa, Iniguez, Carmen, Peretz, Chava, Wolf, Tanja, Michelozzi, Paola, School of Medicine, Lazio Regional Health Service [Rome], University of Athens Medical School [Athens], WHO European Centre for Environment and Health [Bonn] (ECEH), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), IMIM-Hospital del Mar, Generalitat de Catalunya, Center for Research in Environmental Epidemiology (CREAL), Universitat Pompeu Fabra [Barcelona] (UPF)-Catalunya ministerio de salud, CIBER de Epidemiología y Salud Pública (CIBERESP), Laboratoire d'Epidémiologie Médicale, Institut Pasteur de Tunis, Institut Pasteur de Tunis, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), University of Lisboa, Koç University, Universidad de Valencia, Center for Public Health Research [Valencia] (CSISP), Tel Aviv University [Tel Aviv], This article has been written for the CIRCE project that was funded by the Commission of the European Communities, Research Directorate General (6th Framework Program, Priority 1.1.6.3 Global Change and Ecosystem, Contract N° GOCE-036961), and Authors would like to thank all the institutions and colleagues who provided health and environmental data. The health part of the CIRCE project was coordinated by WHO Regional Office for Europe.
Subjects: Mediterranean climate, Male, MESH: Urban Health, Hot Temperature, Time Factors, Climate, Health, Toxicology and Mutagenesis, Vulnerability, 010501 environmental sciences, 01 natural sciences, Mediterranean Basin, MESH: Regression Analysis, MESH: Cause of Death, 0302 clinical medicine, Africa, Northern, MESH: Child, Cause of Death, 11. Sustainability, 030212 general & internal medicine, Mediterranean region, Socioeconomics, Child, MESH: Aged, [SDV.EE]Life Sciences [q-bio]/Ecology, environment, Middle East, MESH: Middle Aged, MESH: Infant, Newborn, 1. No poverty, Age Factors, Middle Aged, MESH: Climate, MESH: Middle East/epidemiology, MESH: Infant, 3. Good health, Geography, MESH: Young Adult, Child, Preschool, 8. Economic growth, Regression Analysis, Female, Seasons, Adult, medicine.medical_specialty, Adolescent, Climate change, Heat Stress Disorders, MESH: Mediterranean Region/epidemiology, 03 medical and health sciences, Young Adult, medicine, MESH: Cities, Humans, Cities, Mortality, MESH: Heat Stress Disorders/mortality, 0105 earth and related environmental sciences, MESH: Hot Temperature/adverse effects, Aged, Estimation, MESH: Adolescent, MESH: Age Factors, MESH: Heat Stress Disorders/etiology, MESH: Humans, Public health, Research, MESH: Child, Preschool, MESH: Time Factors, Infant, Newborn, Urban Health, Public Health, Environmental and Occupational Health, MESH: Africa, Northern/epidemiology, Infant, MESH: Adult, MESH: Male, Apparent temperature, 13. Climate action, Hot temperature, Heterogeneity, Age groups, Public Health, TIME series analysis, Older people, Unemployment statistics, Climatic changes, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Mortality/trends, MESH: Female, MESH: Seasons, Medicine, Geriatrics
Abstract: Background: The Mediterranean region is particularly vulnerable to the effect of summer temperature. Within the CIRCE project this time-series study aims to quantify for the first time the effect of summer temperature in Eastern-Southern Mediterranean cities and compared it with European cities around the Mediterranean basin, evaluating city characteristics that explain between-city heterogeneity. Methods: The city-specific effect of maximum apparent temperature (Tappmax) was assessed by Generalized Estimation Equations, assuming a linear threshold model. Then, city-specific estimates were included in a random effect meta-regression analysis to investigate the effect modification by several city characteristics. Results: Heterogeneity in the temperature-mortality relationship was observed among cities. Thresholds recorded higher values in the warmest cities of Tunis (35.5 degrees C) and Tel-Aviv (32.8 degrees C) while the effect of Tappmax above threshold was greater in the European cities. In Eastern-Southern Mediterranean cities a higher effect was observed among younger age groups (0-14 in Tunis and 15-64 in Tel-Aviv and Istanbul) in contrast with the European cities where the elderly population was more vulnerable. Climate conditions explained most of the observed heterogeneity and among socio-demographic and economic characteristics only health expenditure and unemployment rate were identified as effect modifiers. Conclusions: The high vulnerability observed in the young populations in Eastern-Southern Mediterranean cities represent a major public health problem. Considering the large political and economic changes occurring in this region as well future temperature increase due to climate change, it is important to strengthen research and public health efforts in these Mediterranean countries., Commission of the European Communities, Research Directorate General (6th Framework Program, Priority 1.1.6.3 Global Change and Ecosystem)
Published: 2013
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23. Usefulness of a single-item measure of depression to predict mortality: the GAZEL prospective cohort study

Author: Lefèvre, Thomas, Singh-Manoux, Archana, Stringhini, Silvia, Dugravot, Aline, Lemogne, Cédric, Consoli, Silla, Goldberg, Marcel, Zins, Marie, Nabi, Hermann, Laboratoire de Traitement de l'Information Medicale (LaTIM), Université européenne de Bretagne - European University of Brittany (UEB)-Université de Brest (UBO)-Télécom Bretagne-Institut Mines-Télécom [Paris] (IMT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Department of Epidemiology and Public Health, University College of London [London] (UCL), Centre de Gérontologie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Sainte Perine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris Descartes - Paris 5 (UPD5), Service Universitaire de Psychiatrie de l'Adulte et du sujet âgé, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Centre Emotion, Université Pierre et Marie Curie - Paris 6 (UPMC)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS), The GAZEL cohort study was funded by EDF-GDF and INSERM, and received grants from the Cohortes Santé TGIR Program. ASM is supported by a EUYRI award from the European Science Foundation and the National Institute on Aging, NIH (R01AG013196, and R01AG034454).
Subjects: MESH: Psychiatric Status Rating Scales, MESH: Socioeconomic Factors, MESH: Humans, MESH: Middle Aged, MESH: Depression, MESH: Questionnaires, MESH: Health Behavior, MESH: Adult, MESH: Follow-Up Studies, mortality, MESH: Predictive Value of Tests, MESH: Prospective Studies, MESH: Male, MESH: Cause of Death, MESH: Proportional Hazards Models, MESH: France, MESH: Risk Factors, depression, single-item, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Female
Abstract: International audience; BACKGROUND: It remains unknown whether short measures of depression perform as well as long measures in predicting adverse outcomes such as mortality. The present study aims to examine the predictive value of a single-item measure of depression for mortality. METHODS: A total of 14,185 participants of the GAZEL cohort completed the 20-item Center-for-Epidemiologic-Studies-Depression (CES-D) scale in 1996. One of these items (I felt depressed) was used as a single-item measure of depression. All-cause mortality data were available until 30 September 2009, a mean follow-up period of 12.7 years with a total of 650 deaths. RESULTS: In Cox regression model adjusted for baseline socio-demographic characteristics, a one-unit increase in the single-item score (range 0-3) was associated with a 25% higher risk of all-cause mortality (95% CI: 13-37%, P
Published: 2012
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24. Independent association of urinary F2-isoprostanes with survival in pulmonary arterial hypertension

Author: Jean-Charles Renversez, Jean-Luc Cracowski, Ari Chaouat, Patrice Faure, Luigi Iuliano, François Chabot, José Labarère, Claire Cracowski, Edzard Schwedhelm, Azzedine Yaici, Carole Schwebel, Martine Reynaud-Gaubert, Bruno Degano, Denis Monneret, Gérald Simonneau, Olivier Sitbon, Marc Humbert, Renke Maas, Hypoxie et physiopathologies cardiovasculaire et respiratoire, Institut National de la Santé et de la Recherche Médicale (INSERM), CIC - Grenoble, Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de médecine moléculaire de Rangueil (I2MR), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-IFR150-Institut National de la Santé et de la Recherche Médicale (INSERM), Physiopathologie cardiovasculaire et prévention, Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Département de physiologie, Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), BCM, Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-CHU Grenoble, VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF), Department of Medico-Surgical Sciences & Biotechnologies, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Service de Réanimation Médicale [Grenoble], CHU Grenoble-Hôpital Michallon, Service des Maladies Infectieuses et Tropicales [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Service de chirurgie thoracique, Assistance Publique - Hôpitaux de Marseille (APHM)-Hôpital nord, Département de biologie intégrée, Hypertension arterielle pulmonaire physiopathologie et innovation thérapeutique, Centre chirurgical Marie Lannelongue-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de pneumologie [Béclère], AP-HP - Hôpital Antoine Béclère [Clamart], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)
Subjects: Male, Isoprostane, medicine.medical_treatment, Kaplan-Meier Estimate, 030204 cardiovascular system & hematology, Critical Care and Intensive Care Medicine, MESH: Lipid Peroxidation, MESH: Cause of Death, chemistry.chemical_compound, 0302 clinical medicine, Risk Factors, MESH: Risk Factors, Cause of Death, Familial Primary Pulmonary Hypertension, Cause of death, F2-Isoprostanes, MESH: Middle Aged, Hazard ratio, MESH: Enzyme-Linked Immunosorbent Assay, Venous blood, MESH: Follow-Up Studies, Middle Aged, Prognosis, 3. Good health, Survival Rate, Cardiology, Female, MESH: F2-Isoprostanes, France, Cardiology and Cardiovascular Medicine, Pulmonary and Respiratory Medicine, medicine.medical_specialty, MESH: Survival Rate, Hypertension, Pulmonary, Enzyme-Linked Immunosorbent Assay, Gas Chromatography-Mass Spectrometry, MESH: Prognosis, 03 medical and health sciences, Internal medicine, medicine, Lung transplantation, Humans, Survival rate, MESH: Kaplan-Meier Estimate, Retrospective Studies, MESH: Humans, MESH: Hypertension, Pulmonary, business.industry, MESH: Biological Markers, MESH: Retrospective Studies, medicine.disease, Pulmonary hypertension, MESH: Male, Surgery, MESH: Gas Chromatography-Mass Spectrometry, MESH: France, 030228 respiratory system, chemistry, Heart catheterization, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Lipid Peroxidation, business, MESH: Female, Biomarkers, Follow-Up Studies
Abstract: International audience; OBJECTIVES: Within the past decade, biochemical markers have emerged as attractive tools to assess pulmonary arterial hypertension (PAH) prognosis, being noninvasive and easily repeatable.The objective of this study was to determine whether biomarkers measured at initial diagnostic right-sided heart catheterization predict 3-year all-cause mortality for incident cases of PAH independently of clinical and hemodynamic parameters. METHODS: Patients with incident PAH were enrolled between December 2003 and April 2006 in six centers from the French Network on Pulmonary Hypertension and followed for 3 years.Venous blood samples were taken during right-sided heart catheterization, and analyses were centralized. RESULTS: Among 110 enrolled patients, 11 underwent lung or heart/lung transplantation, and 27 died during follow-up. The Kaplan-Meier estimates of survival were 91%, 78%, and 75% at 1, 2, and 3 years, respectively. Plasma big endothelin-1 (hazard ratio [HR] per 1-SD increase, 1.48; 95% CI,1.14-1.92), serum troponin T . 0.01 mg/L (HR, 2.35; 95% CI, 1.05-5.29), and urinary F 2 -isoprostanes(15-F2t -isoprostane) (HR per 1-SD increase, 1.76; 95% CI, 1.31-2.36) were associated with increased unadjusted hazard of death. In multivariate analysis adjusting for patient characteristics, the level of urinary F 2 -isoprostanes was the only biomarker that remained independently associated with increased hazard of death (HR per 1-SD increase, 1.82; 95% CI, 1.28-2.60). CONCLUSIONS: This study shows that levels of urinary F 2 -isoprostane, a biomarker of lipid peroxidation,quantified at initial diagnostic right-sided heart catheterization are independently associated with mortality in a cohort of patients with incident PAH.
Published: 2012
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25. Mortality differences between the foreign-born and locally-born population in France (2004-2007)

Author: Grégoire Rey, Eric Jougla, Yves Breem, Roxane Boulogne, Anton E. Kunst, Centre d'épidémiologie sur les causes médicales de décès (CépiDc), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Département des Statistiques, des Etudes et de la Documentation, Division Enquêtes et Etudes Statistiques, Ministère de l'Immigration, de l'Intégration, de l'Identité Nationale et du Développement Solidaire, Department of Public Health, University of Amsterdam [Amsterdam] (UvA), INSERM, APH - Amsterdam Public Health, Public and occupational health, and Camelin, Laurence
Subjects: Male, MESH: Urban Health, Health (social science), Immigration, Poison control, MESH: Risk Assessment, MESH: Cause of Death, 0302 clinical medicine, MESH: Child, 030212 general & internal medicine, Europe, Eastern, 10. No inequality, Child, Cause of death, media_common, MESH: Aged, education.field_of_study, MESH: Europe, Eastern, MESH: Middle Aged, MESH: Asia, Mortality differential, MESH: Sex Distribution, Middle Aged, MESH: Emigrants and Immigrants, MESH: Asia, Central, 3. Good health, Morocco, Geography, MESH: Young Adult, Child, Preschool, Asia, Central, Female, France, 0305 other medical science, Adult, Asia, Adolescent, media_common.quotation_subject, Population, Emigrants and Immigrants, Risk Assessment, 03 medical and health sciences, Young Adult, Foreign born, Age Distribution, History and Philosophy of Science, Country of birth, Injury prevention, Healthy migrant effect, MESH: United States, Humans, Mortality, Sex Distribution, education, Socioeconomic status, MESH: Age Distribution, Aged, MESH: Adolescent, 030505 public health, MESH: Humans, MESH: Mortality, MESH: Child, Preschool, Urban Health, MESH: Adult, Country of origin, United States, MESH: Male, MESH: France, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Morocco, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Female, Demography
Abstract: International audience; In contrast to the situation in many European countries, the mortality of immigrants in France has been little studied. The main reasons for the lack of studies are based on ethical and ideological considerations. The objective of this study is to explore mortality by country of birth in Metropolitan (i.e. 'mainland') France. Complete mortality data were used to study the relative risks of mortality of the foreign- and locally-born populations by gender, age and cause of death for the period 2004-2007 in Metropolitan France. Analyses were conducted by countries of birth grouped into geographic areas and by the Human Development Index (HDI). The differentials in mortality between foreign-born and locally-born populations were not homogeneous. The figures varied by age (higher foreign-born mortality for the young; lower mortality for migrants aged 15-64 years), gender (female migrants more frequently had higher relative mortality than men migrants), country of birth (Eastern European-born migrants had higher mortality, while those born in Morocco, Central Asia, 'other Asian countries' and America had lower mortality) and cause of death (migrant mortality was higher overall for deaths caused by infectious diseases and diabetes, and lower for violent death and neoplasm). Moreover, mortality relative risks for male, violent deaths and cancer were positively associated with country-of-birth HDI, while female mortality and infectious disease mortality were negatively associated with country-of-birth HDI. Some important caveats have to be considered because the study did not control for individuals socioeconomic position in France, or length of residence in the host country. A strong healthy migrant effect was suggested and its intensity varies with age and gender (which may reflect different reasons for migration). For some specific causes of death, a lifestyle effect seems to explain mortality differentials. The associations between HDI and mortality show that mortality trends are partly related to the educational, sanitary and economic conditions of the country of birth. Further studies would enrich the differential analysis of mortality by country of birth by contributing additional detailed data on socioeconomic and living conditions in the host country as well as in the country of origin.
Published: 2012
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26. Younger donor's age and upfront tandem are two independent prognostic factors for survival in multiple myeloma patients treated by tandem autologous-allogeneic stem cell transplantation: a retrospective study from the Société Française de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC)

Author: Jean-Henri Bourhis, Frédéric Garban, Mohamad Mohty, Nathalie Contentin, Gérard Socié, Sylvie François, Mauricette Michallet, Nathalie Fegueux, Madalina Uzunov, Serge Koscielny, Natacha Maillard, Ibrahim Yakoub-Agha, Simona Lapusan, Didier Blaise, Claire Fabre, Reza Tabrizi, Hématopoïèse normale et pathologique, Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherche en Cancérologie Nantes-Angers (CRCNA), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM)-Hôtel-Dieu de Nantes-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Laennec-Centre National de la Recherche Scientifique (CNRS)-Faculté de Médecine d'Angers-Centre hospitalier universitaire de Nantes (CHU Nantes), Service d'hématologie et oncologie médicale, Hôpital Lapeyronie-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université Montpellier 1 (UM1)-Université de Montpellier (UM), Hôpital Haut-Lévêque, Université Sciences et Technologies - Bordeaux 1-CHU Bordeaux [Bordeaux], Service Hématologie, Centre hospitalier universitaire de Poitiers (CHU Poitiers)-Hôpital Jean Bernard, Service d'hématologie [Hôpital Edouard Herriot - HCL], Hôpital Edouard Herriot [CHU - HCL], Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Service d'hématologie greffe [Saint-Louis], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), UAM Allogreffes de CSH, Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), TheREx, Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Département de cancérologie et d'hématologie, and CHU Grenoble-Hôpital Michallon-CHU Grenoble-Hôpital Michallon
Subjects: Male, Oncology, MESH: Tissue Donors, MESH: Registries, MESH: Multiple Myeloma, [SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity, MESH: Cause of Death, 0302 clinical medicine, Recurrence, Cause of Death, Registries, Prospective cohort study, Multiple myeloma, Cause of death, MESH: Treatment Outcome, MESH: Aged, MESH: Middle Aged, Mortality rate, Age Factors, Hematopoietic Stem Cell Transplantation, Hematology, Middle Aged, Prognosis, Tissue Donors, MESH: Transplantation, Autologous, 3. Good health, Treatment Outcome, MESH: Young Adult, 030220 oncology & carcinogenesis, MESH: Survival Analysis, Female, Multiple Myeloma, Adult, medicine.medical_specialty, Transplantation, Autologous, MESH: Prognosis, Young Adult, 03 medical and health sciences, Internal medicine, medicine, MESH: Transplantation, Homologous, Humans, Transplantation, Homologous, Autologous transplantation, Survival analysis, MESH: Hematopoietic Stem Cell Transplantation, Aged, Retrospective Studies, MESH: Age Factors, MESH: Humans, business.industry, Retrospective cohort study, MESH: Adult, MESH: Retrospective Studies, medicine.disease, Survival Analysis, MESH: Male, Surgery, MESH: Recurrence, Transplantation, MESH: Morbidity, Original Articles and Brief Reports, Morbidity, business, MESH: Female, 030215 immunology
Abstract: International audience; BACKGROUND: How tandem autologous-allogeneic stem cell transplantation should be integrated in the treatment of multiple myeloma remains controversial. We examined the long-term outcome of patients with multiple myeloma managed with tandem autologous-allogeneic stem cell transplantation and present a prognostic factor analysis based on the experience of the Société Française de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC). DESIGN AND METHODS: This French, retrospective, registry-based study included 146 patients who had undergone tandem autologous-allogeneic transplantation for multiple myeloma at 20 SFGM-TC centers between 1998 and 2010. The patients included in the study had fully completed the two steps of a planned tandem autologous-allogeneic transplantation. No treatment had to be administered between the autologous and allogeneic parts of the tandem procedure. RESULTS: Seventy-seven patients (53%) underwent tandem autologous-allogeneic transplantation as part of upfront treatment, i.e. after a single line of treatment not including autologous transplantation. The median follow-up from the allogeneic transplant was 47.5 months (range, 1.2-132 months). At 4 years, the overall survival and event-free survival rates were 48% (95% CI 39-57 %) and 27% (95% CI 19-36), respectively. Eighteen patients (12%) experienced grade III-IV acute graft-versus-host disease and 43 patients (30%) had chronic graft-versus-host disease. The transplant-related mortality rate at 1 year was 15% (95% CI 10-22). Patients receiving tandem transplantation as upfront treatment had significantly improved event-free survival (36% versus 11%; P=0.005) and overall survival (56% versus 34%; P=0.02). Donor's age ≤ 50 years was associated with improved event-free survival (35% versus 16%; P=0.005) and overall survival (54% versus 41%; P=0.02). In the multivariable analysis, upfront tandem transplantation, donor's age ≤ 50 years and full chimerism were independent prognostic factors for better outcome. CONCLUSIONS: We confirmed the feasibility of tandem autologour-allogeneic transplantation in heavily treated patients with multiple myeloma. We identified younger donor's age and upfront tandem transplantation as two independent prognostic factors for survival which could be further explored in prospective studies.
Published: 2012
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27. Neuroticism and cardiovascular disease mortality: socioeconomic status modifies the risk in women (UK Health and Lifestyle Survey)

Author: Séverine Sabia, Archana Singh-Manoux, Alexis Elbaz, David Boniface, Ian J. Deary, Gareth Hagger-Johnson, G. David Batty, Beverly A. Roberts, Department of Epidemiology and Public Health, University College of London [London] (UCL), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Dept of Psychology, University of Edinburgh, SZTAJNBOK, Pascale, and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)
Subjects: Male, Gerontology, Neurotic Disorders, Personality Inventory, Health Behavior, MESH: Cause of Death, MESH: Proportional Hazards Models, 0302 clinical medicine, MESH: Health Surveys, Risk Factors, MESH: Risk Factors, Cause of Death, Prospective Studies, 030212 general & internal medicine, Big Five personality traits, 10. No inequality, Applied Psychology, MESH: Aged, MESH: Middle Aged, Hazard ratio, Middle Aged, Neuroticism, 3. Good health, Psychiatry and Mental health, Cardiovascular Diseases, population characteristics, MESH: Great Britain, Female, Psychology, Adult, MESH: Health Behavior, MESH: Social Class, MESH: Women, 03 medical and health sciences, mental disorders, Humans, Women, Risk factor, Socioeconomic status, Aged, Proportional Hazards Models, MESH: Neurotic Disorders, Extraversion and introversion, MESH: Humans, MESH: Cardiovascular Diseases, MESH: Adult, social sciences, Health Surveys, United Kingdom, Confidence interval, Eysenck Personality Questionnaire, MESH: Male, MESH: Prospective Studies, MESH: Personality Inventory, Social Class, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Female, 030217 neurology & neurosurgery, Demography
Abstract: International audience; The association between personality traits and mortality might differ as a function of socioeconomic status (SES). Our aim was to evaluate the all-cause, cardiovascular disease (CVD), and cancer mortality risk associated with neuroticism or extraversion and their interactions with SES in a representative sample of the UK adult population. A total of 5450 participants (2505 men) from the Health and Lifestyle Survey completed the Eysenck Personality Inventory at baseline and were monitored for vital status over 25 years. SES was defined as a latent variable comprising occupational social class, educational attainment, and income. A significant neuroticism-by-SES-by-sex interaction (p = .04) for CVD mortality revealed a neuroticism-by-SES interaction specific to women. Compared to women with average SES, those with both high neuroticism and low SES were at an increased risk for CVD mortality (hazard ratio = 2.02, 95% confidence interval = 1.45-2.80), whereas those with high neuroticism and high SES combined were at a decreased risk for CVD mortality (hazard ratio = 0.61, 95% confidence interval = 0.38-0.97, p for interaction = 0.003). The interaction term was not explained by health behaviors (10% attenuation) and physiological variables (11% attenuation). This interaction was not observed for all-cause and cancer mortality risks or among men for CVD mortality. High neuroticism is a risk factor for cardiovascular mortality in women with low SES, whereas in women with higher SES, it is protective. Further research is needed to replicate this finding and identify the mechanisms behind the modifying effect of SES on neuroticism.
Published: 2012
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28. Effect of intensity and type of physical activity on mortality: results from the Whitehall II cohort study

Author: Eric J. Brunner, Archana Singh-Manoux, Mika Kivimäki, Séverine Sabia, Aline Dugravot, Martin J. Shipley, Schmaus, Annie, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Epidemiology and Public Health, University College of London [London] (UCL), Centre de Gérontologie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Funding sources: AS-M is supported by a 'European Young Investigator Award' from the European Science Foundation, MK is supported by the BUPA Foundation, UK and the Academy of Finland, and MJS is supported by the British Heart Foundation. The Whitehall II study has been supported by grants from the British Medical Research Council (MRC), the British Heart Foundation, the British Health and Safety Executive, the British Department of Health, the National Heart, Lung, and Blood Institute (R01HL036310), the National Institute on Aging (R01AG013196 and R01AG034454)., and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)
Subjects: Adult, Male, 030204 cardiovascular system & hematology, Lower risk, Cohort Studies, MESH: Cause of Death, 03 medical and health sciences, 0302 clinical medicine, Cause of Death, Surveys and Questionnaires, London, Humans, Medicine, Longitudinal Studies, Prospective Studies, 030212 general & internal medicine, Mortality, Exercise physiology, Prospective cohort study, MESH: Longitudinal Studies, Exercise, MESH: Cohort Studies, Aged, Cause of death, MESH: Aged, MESH: Middle Aged, MESH: Humans, MESH: Mortality, business.industry, MESH: Questionnaires, Hazard ratio, Public Health, Environmental and Occupational Health, MESH: Adult, MESH: Follow-Up Studies, Middle Aged, MESH: London, Confidence interval, MESH: Male, MESH: Prospective Studies, Intensity (physics), [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Exercise, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, MESH: Female, Follow-Up Studies, Demography, Cohort study
Abstract: Objectives. We examined the association of intensity and type of physical activity with mortality. Methods. We assessed the duration of physical activity by intensity level and type in 7456 men and women from the Whitehall II Study by questionnaire in 1997–1999 (mean ±SD age = 55.9 ±6.0 years) and 5 years later. All-cause mortality was assessed until April 2009. Results. A total of 317 participants died during the mean follow-up of 9.6 years (SD = 2.7). Reporting at least 1 hour per week of moderate activity was associated with a 33% (95% confidence interval [CI] = 14%, 45%) lower risk of mortality compared with less than 1 hour. For all physical activity types examined, except housework, a duration of physical activity greater than 0 (≥ 3.5 hours for walking) was associated with lower mortality in age-adjusted analyses, but only the associations with sports (hazard ratio [HR] = 0.71; 95% CI = 0.56, 0.91) and do-it-yourself activity (HR = 0.68; 95% CI = 0.53, 0.98) remained in fully adjusted analyses. Conclusions. It is important to consider both intensity and type of physical activity when examining associations with mortality.
Published: 2012
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29. Usefulness of a single-item measure of depression to predict mortality: the GAZEL prospective cohort study.: single-item of depression and mortality

Author: Lefèvre, Thomas, Singh-Manoux, Archana, Stringhini, Silvia, Dugravot, Aline, Lemogne, Cédric, Consoli, Silla, Goldberg, Marcel, Zins, Marie, Nabi, Hermann, Schmaus, Annie, Laboratoire de Traitement de l'Information Medicale (LaTIM), Université européenne de Bretagne - European University of Brittany (UEB)-Université de Brest (UBO)-Télécom Bretagne-Institut Mines-Télécom [Paris] (IMT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Epidemiology and Public Health, University College of London [London] (UCL), Centre de Gérontologie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Sainte Perine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris Descartes - Paris 5 (UPD5), Service Universitaire de Psychiatrie de l'Adulte et du sujet âgé, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Centre Emotion, Université Pierre et Marie Curie - Paris 6 (UPMC)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), The GAZEL cohort study was funded by EDF-GDF and INSERM, and received grants from the Cohortes Santé TGIR Program. ASM is supported by a EUYRI award from the European Science Foundation and the National Institute on Aging, NIH (R01AG013196, and R01AG034454).
Subjects: MESH: Psychiatric Status Rating Scales, MESH: Socioeconomic Factors, MESH: Humans, MESH: Middle Aged, MESH: Depression, MESH: Questionnaires, MESH: Health Behavior, MESH: Adult, MESH: Follow-Up Studies, mortality, MESH: Predictive Value of Tests, MESH: Prospective Studies, MESH: Male, MESH: Cause of Death, MESH: Proportional Hazards Models, MESH: France, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Risk Factors, depression, single-item, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Female
Abstract: International audience; BACKGROUND: It remains unknown whether short measures of depression perform as well as long measures in predicting adverse outcomes such as mortality. The present study aims to examine the predictive value of a single-item measure of depression for mortality. METHODS: A total of 14,185 participants of the GAZEL cohort completed the 20-item Center-for-Epidemiologic-Studies-Depression (CES-D) scale in 1996. One of these items (I felt depressed) was used as a single-item measure of depression. All-cause mortality data were available until 30 September 2009, a mean follow-up period of 12.7 years with a total of 650 deaths. RESULTS: In Cox regression model adjusted for baseline socio-demographic characteristics, a one-unit increase in the single-item score (range 0-3) was associated with a 25% higher risk of all-cause mortality (95% CI: 13-37%, P
Published: 2012
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30. Low conscientiousness and risk of all-cause, cardiovascular and cancer mortality over 17 years: Whitehall II cohort study

Author: Eric J. Brunner, Hermann Nabi, Martin J. Shipley, Séverine Sabia, Mika Kivimäki, Archana Singh Manoux, Gareth Hagger-Johnson, Department of Epidemiology and Public Health, University College of London [London] (UCL), Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Centre de Gérontologie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Sainte Perine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), and SZTAJNBOK, Pascale
Subjects: Gerontology, Male, MESH: Self Report, 050109 social psychology, medicine.disease_cause, MESH: Cause of Death, 0302 clinical medicine, MESH: Risk Factors, Risk Factors, Cause of Death, Neoplasms, MESH: Neoplasms, 030212 general & internal medicine, Longitudinal Studies, Big Five personality traits, conscientiousness, MESH: Longitudinal Studies, media_common, MESH: Middle Aged, 05 social sciences, Perfectionism (psychology), Middle Aged, 3. Good health, Psychiatry and Mental health, Clinical Psychology, Cardiovascular Diseases, Female, perfectionism, Cohort study, Personality, Adult, socio-economic status, media_common.quotation_subject, MESH: Social Support, Article, 03 medical and health sciences, Social support, MESH: Personality, cohort study, medicine, Whitehall Study, Humans, 0501 psychology and cognitive sciences, Risk factor, MESH: Humans, business.industry, MESH: Cardiovascular Diseases, Social Support, MESH: Adult, Conscientiousness, mortality, MESH: Male, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, personality traits, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Self Report, business, MESH: Female, Demography
Abstract: International audience; To examine the personality trait conscientiousness as a risk factor for mortality and to identify candidate explanatory mechanisms. Participants in the Whitehall II cohort study (N=6800, aged 34 to 55 at recruitment in 1985) completed two self-reported items measuring conscientiousness in 1991-1993 ('I am overly conscientious' and 'I am overly perfectionistic', Cronbach's α=.72), the baseline for this study. Age, socio-economic status (SES), social support, health behaviours, physiological variables and minor psychiatric morbidity were also recorded at baseline. The vital status of participants was then monitored for a mean of 17 years. All-cause and cause-specific mortality was ascertained through linkage to a national mortality register until January 2010. Each 1 standard deviation decrease in conscientiousness was associated with a 10% increase in all-cause (hazard ratio [HR]=1.10, 95% CI 1.003, 1.20) mortality. Patterns were similar for cardiovascular (HR=1.17, 95% CI 0.98, 1.39) and cancer mortality (HR=1.10, 95% CI 0.96, 1.25), not reaching statistical significance. The association with all-cause mortality was attenuated by 5% after adjustment for SES, 13% for health behaviours, 14% for cardiovascular risk factors, 5% for minor psychiatric morbidity, 29% for all variables. Repeating analyses with each item separately and excluding participants who died within five years of personality assessment did not change the results materially. Low conscientiousness in midlife is a risk factor for all-cause mortality. This association is only partly explained by health behaviours, SES, cardiovascular disease risk factors and minor psychiatric morbidity in midlife.
Published: 2011
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31. Isolated left ventricular non-compaction in adults: clinical and echocardiographic features in 105 patients. Results from a French registry

Author: Thierry Laperche, Alain Cohen-Solal, Guillaume Jondeau, Damien Logeart, Cécile Pascal, Dominique Boulmier, Philippe Charron, Gilbert Habib, Roch Giorgi, Erwan Donal, Jean-Christophe Eicher, Service de cardiologie, Université de la Méditerranée - Aix-Marseille 2-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service de Cardiologie [CHU de Dijon], Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Service de Santé Publique et d'Information Médicale (SSPIM), Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Laboratoire d'Enseignement et de Recherche sur le Traitement de l'Information Médicale (LERTIM), Université de la Méditerranée - Aix-Marseille 2, Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de cardiologie et maladies vasculaires [Rennes] = Cardiac, Thoracic, and Vascular Surgery [Rennes], CHU Pontchaillou [Rennes], CIC-IT Rennes, Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Biomarqueurs CArdioNeuroVASCulaires (BioCANVAS), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hémostase, bio-ingénierie et remodelage cardiovasculaires (LBPC), Université Paris Diderot - Paris 7 (UPD7)-Université Paris 13 (UP13)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Galilée, Heart Failure and Cardiomyopathies, Echocardiography of the French Society of Cardiology, Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Institut Galilée-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: Male, MESH: Registries, medicine.medical_treatment, Cardiomyopathy, 030204 cardiovascular system & hematology, MESH: Risk Assessment, Severity of Illness Index, MESH: Proportional Hazards Models, MESH: Cause of Death, Cohort Studies, Ventricular Dysfunction, Left, 0302 clinical medicine, Cause of Death, MESH: Ventricular Dysfunction, Left, 030212 general & internal medicine, Prospective Studies, Registries, Prospective cohort study, MESH: Cohort Studies, Cause of death, Heart transplantation, MESH: Statistics, Nonparametric, Ejection fraction, MESH: Middle Aged, MESH: Confidence Intervals, Middle Aged, Prognosis, 3. Good health, Echocardiography, MESH: Survival Analysis, Cardiology, Disease Progression, MESH: Disease Progression, [SDV.IB]Life Sciences [q-bio]/Bioengineering, Female, France, medicine.symptom, Cardiology and Cardiovascular Medicine, Cardiomyopathies, Adult, medicine.medical_specialty, Heart Ventricles, Asymptomatic, Risk Assessment, MESH: Prognosis, Statistics, Nonparametric, 03 medical and health sciences, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Internal medicine, MESH: Severity of Illness Index, medicine, Confidence Intervals, Humans, Proportional Hazards Models, Heart Failure, MESH: Humans, business.industry, MESH: Adult, medicine.disease, Survival Analysis, MESH: Male, MESH: Prospective Studies, Transplantation, MESH: France, Left ventricular non-compaction, MESH: Cardiomyopathies, Heart failure, MESH: Heart Failure, MESH: Echocardiography, MESH: Heart Ventricles, business, MESH: Female
Abstract: International audience; AIMS: The clinical features, prognosis, and even definition of left ventricular non-compaction (LVNC) are still the subject of much debate. The aim of this registry was to describe the clinical, echocardiographic, and prognostic features of LVNC in France. The main endpoint was to assess clinical and echocardiographic predictors of adverse outcome, defined as death or heart transplantation. METHODS AND RESULTS: Between 2004 and 2006, 154 suspected cases of LNVC were identified from a nationwide survey in France. The diagnosis of LVNC was confirmed in 105 cases by echocardiographic evaluation in a core laboratory. Clinical and echocardiographic data for the 105 cases of LVNC are presented. Left ventricular non-compaction was first detected from heart failure symptoms in 45 patients, rhythm disorders in 12, and familial screening in 8. Left ventricular ejection fraction (LVEF) was < 30% in 46% of patients, but ≥ 50% in 16%. The latter had less symptoms of severe heart failure (11 vs. 54%, P = 0.001), but similar extension of the NC zone. During 2.33 ± 1.47 years of follow-up, several complications occurred, including severe heart failure in 33 patients, transplantation in 9, ventricular arrhythmia in 7, embolic events in 9, and death in 12. Factors associated with death or heart transplantation were NYHA 3 or 4 (HR = 6.69; P = 0.0007), high LV filling pressures (HR = 7.59; P = 0.001), LVEF (HR = 0.93; P = 0.006), and hospitalization for heart failure (HR = 13.55; P < 0.0001). CONCLUSION: In this large reported series of LVNC, we observed that: (i) Left ventricular non-compaction was detected by familial screening in asymptomatic patients in 8% of cases. (ii) Left ventricular non-compaction was frequently over-diagnosed by echocardiography. (iii) Patients identified as LVNC presented with a high risk of severe complications, transplantation or death and needed close follow-up.
Published: 2011
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32. When to initiate combined antiretroviral therapy to reduce mortality and AIDS-defining illness in HIV-infected persons in developed countries: an observational study

Author: Consuelo Viladés, Federico Pulido, Julia Del amo, INMA JARRIN, Miguel Hernán, Enrique Bernal Morell, Louisa Gnatiuc Friedrichs, Roberto Muga, Jean-Francois Bergmann, Aba Mahamat, Concepción Cepeda, Clifford Leen, Dominique Costagliola, Patrick Taffé, Montserrat Vargas Laguna, Marcela Guevara, Soraya Boucherit, José A. Oteo, Viktor Von Wyl, Moreno-Cuerda Victor, Jonathan Sterne, Valerie Delpech, Alexandra Montoliu, Eugenia Negredo, Victoria Sánchez-Hellín, Sarah Fidler, Sophie Matheron, Angèle Gayet-Ageron, Caroline Sabin, Luis Fernando Lopez.Cortes, Paz Sobrino-Vegas, Cedric Arvieux, Elisa De Lazzari, Philippa Easterbrook, Carmen Cabellos, Department of Epidemiology, Harvard School of Public Health, Research Department of Infection and Population Health [London], University College of London [London] (UCL), Centre for Epidemiological Studies on HIV/AIDS and STI of Catalonia (CEEISCAT), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Departamento de Fisica Aplicada [Bilbao], Universidad del Pais Vasco / Euskal Herriko Unibertsitatea [Espagne] (UPV/EHU), Epidémiologie, stratégies thérapeutiques et virologie cliniques dans l'infection à VIH, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), National Institutes of Health (grants R01-AI073127 and U10-AA013566), the Medical Research Council (grant G0700820)., The HIV-CAUSAL Collaboration, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), University of Zurich, Other departments, AII - Amsterdam institute for Infection and Immunity, Infectious diseases, Other Research, Obstetrics and Gynaecology, Graduate School, APH - Amsterdam Public Health, General Internal Medicine, Paediatric Infectious Diseases / Rheumatology / Immunology, Global Health, and Medical Microbiology and Infection Prevention
Subjects: MESH: CD4 Lymphocyte Count, MESH: Observation, Marginal structural model, HIV Infections/drug therapy/immunology/mortality, HIV Infections, Observation, law.invention, 10234 Clinic for Infectious Diseases, MESH: Proportional Hazards Models, MESH: Cause of Death, 0302 clinical medicine, Randomized controlled trial, law, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Cause of Death, Medicine, 030212 general & internal medicine, Prospective Studies, Prospective cohort study, Cause of death, 0303 health sciences, ddc:618, virus diseases, General Medicine, MESH: HIV Infections, 3. Good health, Anti-Retroviral Agents, Combination, Disease Progression, Drug Therapy, Combination, MESH: Disease Progression, Poverty-related infectious diseases Infectious diseases and international health [N4i 3], Developed country, Cart, Acquired Immunodeficiency Syndrome/drug therapy/immunology/mortality, medicine.medical_specialty, 610 Medicine & health, MESH: Drug Administration Schedule, human-immunodeficiency-virus marginal structural models cd4 cell count hiv-1-infected patients collaborative analysis controlled-trial base-line individuals death survival, Auto-immunity, transplantation and immunotherapy [N4i 4], MESH: Anti-Retroviral Agents, Article, Drug Administration Schedule, 03 medical and health sciences, Pharmacotherapy, Drug Therapy, Internal Medicine, Humans, Intensive care medicine, Proportional Hazards Models, MESH: Developed Countries, MESH: Acquired Immunodeficiency Syndrome, Acquired Immunodeficiency Syndrome, MESH: Humans, 030306 microbiology, business.industry, Developed Countries, MESH: Prospective Studies, CD4 Lymphocyte Count, MESH: Drug Therapy, Combination, 2724 Internal Medicine, Immunology, Observational study, Anti-Retroviral Agents/administration & dosage/therapeutic use, business
Abstract: Contains fulltext : 97513.pdf (Publisher’s version ) (Closed access) BACKGROUND: Most clinical guidelines recommend that AIDS-free, HIV-infected persons with CD4 cell counts below 0.350 x 10(9) cells/L initiate combined antiretroviral therapy (cART), but the optimal CD4 cell count at which cART should be initiated remains a matter of debate. OBJECTIVE: To identify the optimal CD4 cell count at which cART should be initiated. DESIGN: Prospective observational data from the HIV-CAUSAL Collaboration and dynamic marginal structural models were used to compare cART initiation strategies for CD4 thresholds between 0.200 and 0.500 x 10(9) cells/L. SETTING: HIV clinics in Europe and the Veterans Health Administration system in the United States. PATIENTS: 20, 971 HIV-infected, therapy-naive persons with baseline CD4 cell counts at or above 0.500 x 10(9) cells/L and no previous AIDS-defining illnesses, of whom 8392 had a CD4 cell count that decreased into the range of 0.200 to 0.499 x 10(9) cells/L and were included in the analysis. MEASUREMENTS: Hazard ratios and survival proportions for all-cause mortality and a combined end point of AIDS-defining illness or death. RESULTS: Compared with initiating cART at the CD4 cell count threshold of 0.500 x 10(9) cells/L, the mortality hazard ratio was 1.01 (95% CI, 0.84 to 1.22) for the 0.350 threshold and 1.20 (CI, 0.97 to 1.48) for the 0.200 threshold. The corresponding hazard ratios were 1.38 (CI, 1.23 to 1.56) and 1.90 (CI, 1.67 to 2.15), respectively, for the combined end point of AIDS-defining illness or death. Limitations: CD4 cell count at cART initiation was not randomized. Residual confounding may exist. CONCLUSION: Initiation of cART at a threshold CD4 count of 0.500 x 10(9) cells/L increases AIDS-free survival. However, mortality did not vary substantially with the use of CD4 thresholds between 0.300 and 0.500 x 10(9) cells/L.
Published: 2011
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33. Overtime work and incident coronary heart disease: the Whitehall II prospective cohort study

Author: Marianna Virtanen, Michael Marmot, Jussi Vahtera, Martin J. Shipley, Mika Kivimäki, Archana Singh-Manoux, Jane E. Ferrie, Finnish Institute of Occupational Health, Department of Epidemiology and Public Health, University College of London [London] (UCL), Centre de Gérontologie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Sainte Perine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Santé publique et épidémiologie des déterminants professionnels et sociaux de la santé, Epidémiologie, sciences sociales, santé publique (IFR 69), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Department of Public Health, Turku University Hospital (TYKS)-University of Turku-Finnish Institute of Occupational Health, The Whitehall II study has been supported by grants from the Medical Research Council, British Heart Foundation, Health and Safety Executive, Department of Health, National Heart Lung and Blood Institute (HL36310), US, NIH: National Institute on Aging (AG13196 and AG34454), US, NIH, Agency for Health Care Policy Research (HS06516), the John D and Catherine T MacArthur Foundation Research Networks on Successful Midlife Development and Socio-economic Status and Health, and the BUPA Foundation, UK. MK and JV are supported by the Academy of Finland (Projects no. #124271, #124322, #129262 and #132944), MK is additionally supported by the BUPA Foundation Specialist research grant, AS-M is supported by a 'EURYI' award from the European Science Foundation, MJS is supported by the British Heart Foundation and MGM is supported by a MRC Research Professorship., European Project: 38533,EURYI, Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Kaniewski, Nadine, Conférence : European Business Summit 2004 - Research and Innovation : A European Strategy for more growth and jobes - EURYI - 38533 - OLD, and University of Turku-Finnish Institute of Occupational Health-Turku University Hospital (TYKS)
Subjects: Male, Multivariate analysis, Coronary Disease, MESH: Angina Pectoris, Angina, MESH: Cause of Death, stress, 0302 clinical medicine, Risk Factors, MESH: Risk Factors, Cause of Death, Work Schedule Tolerance, Epidemiology, London, 030212 general & internal medicine, Myocardial infarction, Prospective Studies, Prospective cohort study, Cause of death, MESH: Aged, Incidence (epidemiology), Prognosis, 030210 environmental & occupational health, 3. Good health, Occupational Diseases, MESH: Myocardial Infarction, myocardial infarction, Female, Cardiology and Cardiovascular Medicine, Cohort study, Adult, MESH: Occupational Diseases, medicine.medical_specialty, working hours, MESH: Prognosis, Angina Pectoris, angina, 03 medical and health sciences, Clinical Research, Internal medicine, medicine, Humans, middle-aged, Aged, MESH: Work Schedule Tolerance, MESH: Humans, business.industry, MESH: Adult, prospective, MESH: London, medicine.disease, MESH: Prospective Studies, MESH: Male, CHD, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Physical therapy, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Coronary Disease, business, MESH: Female
Abstract: International audience; AIMS: To examine the association between overtime work and incident coronary heart disease (CHD) among middle-aged employees. METHODS AND RESULTS: Six thousand and fourteen British civil servants (4262 men and 1752 women), aged 39-61 years who were free from CHD and worked full time at baseline (1991-1994), were followed until 2002-2004, an average of 11 years. The outcome measure was incident fatal CHD, clinically verified incident non-fatal myocardial infarction (MI), or definite angina (a total of 369 events). Cox proportional hazard models adjusted for sociodemographic characteristics showed that 3-4 h overtime work per day was associated with 1.60-fold (95% CI 1.15-2.23) increased risk of incident CHD compared with employees with no overtime work. Adjustment for all 21 cardiovascular risk factors measured made little difference to these estimates (HR 1.56, 95% CI 1.11-2.19). This association was replicated in multivariate analysis with only fatal cardiovascular disease and incident non-fatal MI as the outcome (HR 1.67, 95% CI 1.02-2.76). CONCLUSION: Overtime work is related to increased risk of incident CHD independently of conventional risk factors. These findings suggest that overtime work adversely affects coronary health.
Published: 2010
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34. Isolated skin recurrence following salvage mastectomy for intramammary recurrence (after initial breast conservation therapy): is it a fatal event?

Author: Jean Lévêque, Isabelle Ninet, Vincent Lavoué, Philippe Porée, Philippe Descamps, Karine Morcel, Habiba Mesbah, Manon Raimbault, Isabelle Hornung, Gilles Body, Département de chirurgie, CRLCC Eugène Marquis (CRLCC), Service de Gynécologie et Obstétrique [Rennes] = Gynaecology [Rennes], CHU Pontchaillou [Rennes], Service de Gynécologie-Obstétrique, Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM), Centre Olympe de Gouge, De Villemeur, Hervé, Service de Gynécologie-Obstétrique [CHRU Tours], and Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)
Subjects: Oncology, Multivariate analysis, Skin Neoplasms, medicine.medical_treatment, Mastectomy, Segmental, MESH: Cause of Death, 0302 clinical medicine, Breast cancer, Cause of Death, Overall survival, 030212 general & internal medicine, Inflammatory, Mastectomy, MESH: Treatment Outcome, Univariate analysis, MESH: Middle Aged, Neoplasms, Second Primary, General Medicine, MESH: Neoplasm Staging, Middle Aged, Prognosis, 3. Good health, MESH: Salvage Therapy, Treatment Outcome, 030220 oncology & carcinogenesis, MESH: Survival Analysis, Female, France, Breast carcinoma, MESH: Neoplasm Recurrence, Local, Adult, medicine.medical_specialty, MESH: Neoplasms, Second Primary, recurrence, [SDV.CAN]Life Sciences [q-bio]/Cancer, Breast Neoplasms, [SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics, MESH: Prognosis, 03 medical and health sciences, [SDV.CAN] Life Sciences [q-bio]/Cancer, Internal medicine, MESH: Analysis of Variance, medicine, Humans, Skin recurrence, MESH: Mastectomy, Segmental, Neoplasm Staging, Retrospective Studies, Salvage Therapy, Chemotherapy, Analysis of Variance, MESH: Humans, Radiotherapy, business.industry, MESH: Skin Neoplasms, Retrospective cohort study, MESH: Adult, MESH: Retrospective Studies, medicine.disease, Recurrence-free survival, Survival Analysis, Radiation therapy, MESH: France, [SDV.MHEP.GEO] Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics, Surgery, Neoplasm Recurrence, Local, business, MESH: Female, MESH: Breast Neoplasms
Abstract: International audience; AIMS: The authors analyzed the outcome of patients with Isolated Skin Recurrence After Salvage Mastectomy (ISRASM) performed after conservative treatment for breast carcinoma, taking into account initial tumor characteristics, intramammary recurrence (first recurrence) characteristics, local skin recurrence (second recurrence) characteristics, and the type of treatment at each stage of the breast cancer continuum. METHODS: Forty-two patients who had ISRASM between 1976 and 2007 were included in this retrospective study. Twenty-six factors were studied in univariate and multivariate analyses. RESULTS: Mean Overall Survival (OS) was 70.3 (±4.1) months. The 5-year OS rate was 66.6%. 31% of patients did not present any recurrence, 52% had locoregional recurrence and 14% metastatic recurrence following ISRASM. Univariate analysis showed that 4 prognostic factors were significantly related to OS and/or Disease-Free Survival (DFS): (1) initial chemotherapy after primary breast cancer (P = 0.09 and 0.01 respectively), (2) presence of emboli at the site of intramammary recurrence (first recurrence) (P = 0.02 and 0.03), (3) interval between first and second surgery of less than 3 years (P = 0.09 and 0.0003), and (4) inflammatory skin involvement at ISRASM (P = 0.005 and 0.17). Multivariate analysis showed that presence of emboli at the site of intramammary recurrence was significantly related to OS and that an interval between first and second recurrence of less than 3 years was significantly related to DFS. CONCLUSION: Our results show that ISRASM affects a group of breast cancer patients with predominantly local rather than metastatic disease. Prognostic factors depend on characteristics at initial breast cancer, first recurrence and second recurrence. Evidence-based guidelines are still required for ISRASM management.
Published: 2010
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35. Causes of death in HIV-infected women: persistent role of AIDS. The 'Mortalité 2000 & 2005' Surveys (ANRS EN19)

Author: Charlotte Lewden, Philippe Morlat, Thierry May, Dominique Salmon, Mojgan Hessamfar-Bonarek, Eric Rosenthal, Fabrice Bonnet, Patrice Cacoub, Geneviève Chêne, Dominique Costagliola, Service de médecine interne et maladies infectieuses [Bordeaux], CHU Bordeaux [Bordeaux]-Groupe hospitalier Saint-André, Epidémiologie et Biostatistique [Bordeaux], Université Bordeaux Segalen - Bordeaux 2-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Santé Publique, d'Epidémiologie et de Développement (ISPED), Université Bordeaux Segalen - Bordeaux 2, Service de médecine interne et centre de référence des maladies rares [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service des Maladies Infectieuses et Tropicales [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Hépatotoxicité et xénobiotiques, Université Bordeaux Segalen - Bordeaux 2-Université Bordeaux Segalen - Bordeaux 2-Service de médecine interne et maladies infectieuses [Bordeaux], CHU Bordeaux [Bordeaux]-Groupe hospitalier Saint-André-CHU Bordeaux [Bordeaux]-Groupe hospitalier Saint-André-Epidémiologie et Biostatistique [Bordeaux], Université Bordeaux Segalen - Bordeaux 2-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Foie, métabolismes et cancer, Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Service de médecine interne [Nice], Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre Hospitalier Universitaire de Nice (CHU Nice)-Hôpital l'Archet, Epidémiologie, stratégies thérapeutiques et virologie cliniques dans l'infection à VIH, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Bordeaux Segalen - Bordeaux 2-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Institut de Santé Publique, d'Epidémiologie et de Développement ( ISPED ), Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Cochin [AP-HP], Service de médecine interne [CHU Pitié-Salpétrière], Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Pitié-Salpêtrière [APHP], Centre Hospitalier Régional Universitaire de Nancy ( CHRU Nancy ), Université Bordeaux Segalen - Bordeaux 2-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Foie, métabolismes et cancer, Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) -Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université Nice Sophia Antipolis ( UNS ), Université Côte d'Azur ( UCA ) -Université Côte d'Azur ( UCA ) -CHU Nice-Hôpital l'Archet, Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and Université Nice Sophia Antipolis (... - 2019) (UNS)
Subjects: Male, Time Factors, Epidemiology, HIV Infections, MESH: Comorbidity, Comorbidity, Disease, Logistic regression, MESH: Cause of Death, 0302 clinical medicine, MESH: Health Surveys, Risk Factors, MESH: Risk Factors, Cause of Death, MESH : Socioeconomic Factors, MESH : Female, 030212 general & internal medicine, Sida, Cause of death, 0303 health sciences, MESH: Middle Aged, biology, MESH : Acquired Immunodeficiency Syndrome, Smoking, Age Factors, General Medicine, MESH: HIV Infections, Middle Aged, MESH : Adult, MESH : Risk Factors, 3. Good health, MESH : Smoking, AIDS, Infectious Diseases, MESH : Comorbidity, Female, [ SDV.MHEP.HEG ] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, Viral disease, women, MESH : Time Factors, Adult, medicine.medical_specialty, MESH: Smoking, MESH: Socioeconomic Factors, Alcohol Drinking, MESH : Male, MESH : Sex Factors, MESH : Health Surveys, causes of death, 03 medical and health sciences, Sex Factors, Acquired immunodeficiency syndrome (AIDS), MESH: Sex Factors, medicine, MESH : HIV Infections, Humans, MESH : Middle Aged, MESH : Cause of Death, MESH: Acquired Immunodeficiency Syndrome, MESH: Age Factors, Acquired Immunodeficiency Syndrome, MESH: Humans, 030306 microbiology, business.industry, Public health, MESH : Humans, MESH: Time Factors, MESH: Adult, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, medicine.disease, biology.organism_classification, HIV infection, Health Surveys, MESH: Male, Surgery, MESH : Alcohol Drinking, Socioeconomic Factors, MESH : Age Factors, business, MESH: Female, MESH: Alcohol Drinking, Demography
Abstract: International audience; BACKGROUND: Little is known about the causes of death in human immunodeficiency virus (HIV)-infected women in the era of combination antiretroviral therapy (ART). METHODS: In the French nationwide Mortalité 2000 and 2005 surveys, physicians reported causes of deaths in HIV-infected adults in 2000 and 2005, using a standardized questionnaire. We used multivariate logistic regression models to study the association between gender and AIDS-defining causes of death, adjusting for other characteristics. RESULTS: Of the 1013 HIV-infected adults who died in 2005, 247 (24%) were women. Half of women were infected through heterosexual contacts, compared with 25% men. In 2005, the proportion of AIDS-defining causes of death was higher in women than in men (43 vs 34%; P = 0.01), whereas it had been the same in 2000 (47% in women and men). In 2005, women died less frequently than men from respiratory malignancies (lung, ear/nose/throat) and cardiovascular disease (9% of all causes of death in women compared with 16% in men; P = 0.004), and suicides or accidents (4 vs 9%; P = 0.02). Socio-economic precariousness, younger age, less alcohol and tobacco consumption and lack of prior ART explained the higher proportion of deaths from AIDS in women compared with men. CONCLUSIONS: The higher proportion of AIDS-related deaths in women is probably explained by two factors: (i) some HIV-infected women, especially migrants in poor socio-economic conditions, may not have access to optimal care; and (ii) a lower prevalence of risk factors for respiratory, cardiovascular and violent deaths means that the risk of dying from non-AIDS causes may be lower in women.
Published: 2010
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36. Venous thromboembolism during pregnancy, postpartum or during contraceptive use

Author: A, Blanco-Molina, L L, Rota, P, Di Micco, B, Brenner, J, Trujillo-Santos, A, Ruiz-Gamietea, M, Monreal, A, Visona, Department of Internal Medicine (DIM - Rio de Janeiro), Federal University of Rio de Janeiro, Department of Internal Medicine (DIM - Cartagena), Hospital Universitario Santa Maria de Rosell, Servicio de Medicina Interna (SMI), Hopital Universitario Germans Trias i Pujol, Département de Médecine Interne et Pneumologie [Brest] (DMIP - Brest), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Groupe d'Etude de la Thrombose de Bretagne Occidentale (GETBO), Université de Brest (UBO)-Institut Brestois Santé Agro Matière (IBSAM), and Université de Brest (UBO)-Université de Brest (UBO)
Subjects: Adult, MESH: Pulmonary Embolism, MESH: Humans, MESH: Registries, Postpartum Period, Pregnancy Complications, Cardiovascular, MESH: Contraceptive Agents, MESH: Adult, MESH: Retrospective Studies, MESH: Pregnancy Complications, Cardiovascular, Venous Thromboembolism, MESH: Venous Thromboembolism, MESH: Cause of Death, MESH: Postpartum Period, MESH: Pregnancy, Contraceptive Agents, Pregnancy, Cause of Death, Humans, Female, Registries, Pulmonary Embolism, MESH: Female, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Retrospective Studies
Abstract: International audience; Venous thromboembolism (VTE) is a leading cause of maternal death during pregnancy or postpartum, and in women using hormonal contraceptives. However, important issues concerning its natural history and therapy remain unsolved, and most of the protocols for treatment of VTE in this patient population are based on data extrapolated from other populations. RIETE is an ongoing registry of consecutive patients with objectively confirmed, symptomatic, acute VTE. We examined the clinical characteristics and three-month outcome of all enrolled women with pregnancy, postpartum or using hormonal contraceptives. As of December 2008, 173 pregnant women, 135 postpartum, and 798 contraceptive users were enrolled. Of these, 438 (40%) presented with pulmonary embolism (PE) and 668 with deep-vein thrombosis (DVT). Most women with acute PE had dyspnea (72%) or chest pain (75%), but only 2.0% had hypoxaemia. During the three-month study period, five women (0.45%; 95% CI: 0.17-1.00) died (3 had fatal PE), 13 (1.18%; 95% CI: 0.66-1.95) had VTE recurrences, and seven (0.63%; 95% CI: 0.28-1.25) major bleeding. Two of the three women with fatal PE died during the first few hours after arriving at the emergency ward, with no time to start any therapy. The outcome of pregnant or postpartum women with VTE is similar to that in contraceptive users, even though the treatment is different. The non-specific nature of PE signs may have caused some delay in PE diagnosis.
Published: 2010
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37. Does sickness absence due to psychiatric disorder predict cause-specific mortality? A 16-year follow-up of the GAZEL occupational cohort study

Author: Hugo Westerlund, Maria Melchior, Marcel Goldberg, Jussi Vahtera, Jenny Head, Jane E. Ferrie, Kristina Alexanderson, Mika Kivimäki, Archana Singh-Manoux, Marie Zins, Kaniewski, Nadine, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Epidemiology and Public Health, University College of London [London] (UCL), Division of Insurance Medicine, Karolinska Institutet [Stockholm], Department of Public Health, Turku University Hospital (TYKS)-University of Turku-Finnish Institute of Occupational Health, Stress Research Institute, Stockholm University, Equipe RPPC, CETAF, and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)
Subjects: Male, Epidemiology, Original Contributions, absenteeism, Cohort Studies, MESH: Cause of Death, cause of death, 0302 clinical medicine, Neoplasms, Medicine, longitudinal studies, MESH: Neoplasms, 030212 general & internal medicine, MESH: Cohort Studies, Depression (differential diagnoses), Cause of death, MESH: Middle Aged, Mental Disorders, Hazard ratio, Smoking, Absolute risk reduction, Middle Aged, 3. Good health, Suicide, Cardiovascular Diseases, depression, Female, Cohort study, Adult, medicine.medical_specialty, MESH: Smoking, Alcohol Drinking, 03 medical and health sciences, work, Humans, MESH: Mental Disorders, Risk factor, Occupations, Psychiatry, MESH: Occupations, MESH: Humans, Proportional hazards model, business.industry, MESH: Cardiovascular Diseases, MESH: Adult, mortality, MESH: Male, 030227 psychiatry, MESH: Absenteeism, MESH: Suicide, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, MESH: Female, MESH: Alcohol Drinking
Abstract: International audience; Mental disorders are a frequent cause of morbidity and sickness absence in working populations; however, the status of psychiatric sickness absence as a predictor of mortality is not established. The authors tested the hypothesis that psychiatric sickness absence predicts mortality from leading medical causes. Data were derived from the French GAZEL cohort study (n = 19,962). Physician-certified sickness absence records were extracted from administrative files (1990-1992) and were linked to mortality data from France's national registry of mortality (1993-2008, mean follow-up: 15.5 years). Analyses were conducted by using Cox regression models. Compared with workers with no sickness absence, those absent due to psychiatric disorder were at increased risk of cause-specific mortality (hazard ratios (HRs) adjusted for age, gender, occupational grade, other sickness absence-suicide: 6.01, 95% confidence interval (CI): 3.07, 11.75; cardiovascular disease: 1.84, 95% CI: 1.10, 3.08; and smoking-related cancer: 1.65, 95% CI: 1.07, 2.53). After full adjustment, the excess risk of suicide remained significant (HR = 5.13, 95% CI: 2.60, 10.13) but failed to reach statistical significance for fatal cardiovascular disease (HR = 1.59, 95% CI: 0.95, 2.66) and smoking-related cancer (HR = 1.31, 95% CI: 0.85, 2.03). Psychiatric sickness absence records could help identify individuals at risk of premature mortality and serve to monitor workers' health.
Published: 2010
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38. Slow walking speed and cardiovascular death in well functioning older adults: prospective cohort study

Author: Christophe Tzourio, Julien Dumurgier, Alexis Elbaz, Annick Alpérovitch, Pierre Ducimetière, Béatrice Tavernier, Unité de recherche Neuroépidémiologie [CHU Pitié-Salpêtrière], Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre Mémoire de Ressources et de Recherche Paris Nord Ile-de-France (CMRR), Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Recherche en épidémiologie et biostatistique, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de médecine gériatrique (CHU de Dijon - Centre gériatrique de Champmaillot - EHPAD), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), The 3C study is conducted under a partnership agreementbetween the Institut National de la Santéet de la Recherche Médicale(INSERM), the Victor Segalen-Bordeaux II University, and the Sanofi-Synthélabo Company. The Fondation pour la Recherche Médicale fundedthe preparation and initiation of the study. The 3C study is also supportedby the Caisse Nationale Maladie des Travailleurs Salariés, DirectionGénérale de la Santé, Haute Autoritéde la Santé, Institut National dePrévention et d’Education pour la Santé(INPES), Conseils Régionaux ofBourgogne, Fondation de France, Ministry of Research-INSERM Program,'Cohortes et collections de données biologiques,'Mutuelle Générale del’Education Nationale, Institut de la Longévité,ConseilGénéral de la Côted’or. JD was supported by a PhD scholarship from the Fondation pour laRecherche Médicale., Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), and SZTAJNBOK, Pascale
Subjects: Male, [SDV]Life Sciences [q-bio], Kaplan-Meier Estimate, Walking, 030204 cardiovascular system & hematology, MESH: Cause of Death, 0302 clinical medicine, MESH: Risk Factors, Risk Factors, Cause of Death, Mass index, 030212 general & internal medicine, Prospective Studies, Prospective cohort study, Gait, General Environmental Science, Cause of death, 2. Zero hunger, MESH: Aged, Hazard ratio, General Engineering, General Medicine, Prognosis, 3. Good health, [SDV] Life Sciences [q-bio], Cardiovascular Diseases, Median body, Female, France, medicine.medical_specialty, MESH: Prognosis, 03 medical and health sciences, Drugs: Cardiovascular System, medicine, MESH: Walking, Humans, Survival analysis, MESH: Kaplan-Meier Estimate, Aged, MESH: Humans, business.industry, MESH: Gait, Research, MESH: Cardiovascular Diseases, Confidence interval, MESH: Male, MESH: Prospective Studies, Preferred walking speed, MESH: France, Epidemiologic Studies, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Physical therapy, General Earth and Planetary Sciences, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, MESH: Female, Demography
Abstract: Objective To study the relation between low walking speed and the risk of death in older people, both overall and with regard to the main causes of death. Design Prospective cohort study. Setting Dijon centre (France) of the Three-City study. Participants 3208 men and women aged ≥65 living in the community, recruited from 1999 to 2001, and followed for an average of 5.1 years. Main outcome measures Mortality, overall and according to the main causes of death, by thirds of baseline walking speed (measured at maximum speed over six metres), adjusted for several potential confounders; Kaplan-Meier survival curves by thirds of baseline walking speed. Vital status during follow-up. Causes of death. Results During 16 414 person years of follow-up, 209 participants died (99 from cancer, 59 from cardiovascular disease, 51 from other causes). Participants in the lowest third of baseline walking speed had an increased risk of death (hazard ratio 1.44, 95% confidence interval 1.03 to 1.99) compared with the upper thirds. Analyses for specific causes of death showed that participants with low walking speed had about a threefold increased risk of cardiovascular death (2.92, 1.46 to 5.84) compared with participants who walked faster. There was no relation with cancer mortality (1.03, 0.65 to 1.70). In stratified analyses, cardiovascular mortality was increased across various strata defined by sex, median age, median body mass index (BMI), and level of physical activity. Conclusion Slow walking speed in older people is strongly associated with an increased risk of cardiovascular mortality.
Published: 2009
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39. Cardiorespiratory risk factors as predictors of 40-year mortality in women and men

Author: Martin J. Shipley, Elizabeth Breeze, Jane E. Ferrie, Jennifer S. Mindell, Mika Kivimäki, Archana Singh-Manoux, George Davey Smith, Department of Epidemiology and Public Health, University College of London [London] (UCL), Santé publique et épidémiologie des déterminants professionnels et sociaux de la santé, Epidémiologie, sciences sociales, santé publique (IFR 69), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Department of Social Medicine, and University of Bristol [Bristol]
Subjects: Male, Respiratory Tract Diseases, Blood Pressure, MESH: Respiratory Function Tests, 030204 cardiovascular system & hematology, Body Mass Index, Cohort Studies, MESH: Cause of Death, 0302 clinical medicine, 1960s, MESH: Risk Factors, Cause of Death, Epidemiology, risk factors, 030212 general & internal medicine, Prospective cohort study, Stroke, MESH: Cohort Studies, cardiorespiratory mortality, MESH: Aged, MESH: Middle Aged, MESH: Heart Diseases, Hazard ratio, Smoking, MESH: Blood Pressure, Middle Aged, 3. Good health, Respiratory Function Tests, Female, Cardiology and Cardiovascular Medicine, Cohort study, Adult, medicine.medical_specialty, MESH: Smoking, Heart Diseases, Article, MESH: Body Mass Index, 03 medical and health sciences, medicine, Humans, 40-year mortality, Risk factor, Aged, MESH: Humans, business.industry, Cardiorespiratory fitness, MESH: Adult, medicine.disease, MESH: Male, Blood pressure, Physical therapy, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Respiratory Tract Diseases, business, MESH: Female, Demography
Abstract: International audience; OBJECTIVE: Most historical studies of cardiorespiratory risk factors as predictors of mortality have been based on men. This study examines whether they predict mortality over long periods in women and men. DESIGN: Prospective cohort study. SETTING: Participants were employees of the General Post Office. METHODS: Risk factor data were collected via clinical examination and questionnaire, 1966-7. Associations between cardiorespiratory risk factors and 40-year mortality were determined for 644 women and 1272 men aged 35-70 at examination. MAIN OUTCOME MEASURES: All-cause, cardiovascular (CVD), cancer and respiratory mortality. RESULTS: Associations between systolic blood pressure and all-cause and stroke mortality were equally strong for women and men, hazard ratio (95% confidence interval) 1.25 (1.1 to 1.4) and 1.18 (1.1 to 1.3); and 2.17 (1.7 to 2.8) and 1.69 (1.4 to 2.1), respectively. Cholesterol was higher in women and was associated with all-cause 1.22 (1.1 to 1.4) and CVD 1.39 (1.2 to 1.7) mortality, while associations between 2-hour glucose and all-cause 1.15 (1.1 to 1.2), coronary heart disease (CHD) 1.25 (1.1 to 1.4) and respiratory mortality 1.21 (1.0 to 1.5) were observed in men. Obesity was associated with stroke in women (2.42 (1.12 to 5.24)) and CHD in men (1.59 (1.02 to 2.49)), while ECG ischaemia was associated with CVD in both sexes. The strongest, most consistent predictor of mortality was smoking in women and poor lung function in men. However, evidence of sex differences in associations between the cardiorespiratory risk factors measured and mortality was sparse. CONCLUSIONS: Data from a 40-year follow-up period show remarkably persistent associations between risk factors and cardiorespiratory and all-cause mortality in women and men.
Published: 2009
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40. Cardiorespiratory risk factors as predictors of 40-year mortality in women and men

Author: Ferrie, Jane, Singh-Manoux, Archana, Kivimaki, Mika, Mindell, Jennifer, Breeze, Elizabeth, Davey Smith, George, Shipley, Martin, Department of Epidemiology and Public Health, University College of London [London] (UCL), Santé publique et épidémiologie des déterminants professionnels et sociaux de la santé, Epidémiologie, sciences sociales, santé publique (IFR 69), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Department of Social Medicine, and University of Bristol [Bristol]
Subjects: MESH: Aged, MESH: Smoking, MESH: Middle Aged, MESH: Humans, MESH: Heart Diseases, MESH: Adult, MESH: Respiratory Function Tests, MESH: Blood Pressure, MESH: Male, MESH: Body Mass Index, MESH: Cause of Death, 1960s, MESH: Risk Factors, risk factors, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, 40-year mortality, MESH: Respiratory Tract Diseases, MESH: Cohort Studies, MESH: Female, cardiorespiratory mortality
Abstract: International audience; OBJECTIVE: Most historical studies of cardiorespiratory risk factors as predictors of mortality have been based on men. This study examines whether they predict mortality over long periods in women and men. DESIGN: Prospective cohort study. SETTING: Participants were employees of the General Post Office. METHODS: Risk factor data were collected via clinical examination and questionnaire, 1966-7. Associations between cardiorespiratory risk factors and 40-year mortality were determined for 644 women and 1272 men aged 35-70 at examination. MAIN OUTCOME MEASURES: All-cause, cardiovascular (CVD), cancer and respiratory mortality. RESULTS: Associations between systolic blood pressure and all-cause and stroke mortality were equally strong for women and men, hazard ratio (95% confidence interval) 1.25 (1.1 to 1.4) and 1.18 (1.1 to 1.3); and 2.17 (1.7 to 2.8) and 1.69 (1.4 to 2.1), respectively. Cholesterol was higher in women and was associated with all-cause 1.22 (1.1 to 1.4) and CVD 1.39 (1.2 to 1.7) mortality, while associations between 2-hour glucose and all-cause 1.15 (1.1 to 1.2), coronary heart disease (CHD) 1.25 (1.1 to 1.4) and respiratory mortality 1.21 (1.0 to 1.5) were observed in men. Obesity was associated with stroke in women (2.42 (1.12 to 5.24)) and CHD in men (1.59 (1.02 to 2.49)), while ECG ischaemia was associated with CVD in both sexes. The strongest, most consistent predictor of mortality was smoking in women and poor lung function in men. However, evidence of sex differences in associations between the cardiorespiratory risk factors measured and mortality was sparse. CONCLUSIONS: Data from a 40-year follow-up period show remarkably persistent associations between risk factors and cardiorespiratory and all-cause mortality in women and men.
Published: 2009
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41. Non-response to baseline, non-response to follow-up and mortality in the Whitehall II cohort

Author: Marko Elovainio, Roberto De Vogli, Alison L. Shortt, Pekka Martikainen, Archana Singh-Manoux, Mika Kivimäki, Martin J. Shipley, Jenny Head, David Gimeno, Jane E. Ferrie, Michael Marmot, Department of Epidemiology and Public Health, University College of London [London] (UCL), Unit of Excellence for Psychosocial Factors, Finnish Institute of Occupational Health, Santé publique et épidémiologie des déterminants professionnels et sociaux de la santé, Epidémiologie, sciences sociales, santé publique (IFR 69), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Helsinki Collegium for Advanced Studies, Kaniewski, Nadine, and Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: Gerontology, Male, Epidemiology, Health Behavior, Cohort Studies, MESH: Cause of Death, 0302 clinical medicine, MESH: Health Surveys, Surveys and Questionnaires, Cause of Death, Medicine, Socioeconomic inequalities, 030212 general & internal medicine, MESH: Cohort Studies, Cause of death, MESH: Middle Aged, medicine.diagnostic_test, White-collar, Absolute risk reduction, General Medicine, Middle Aged, All-cause mortality, 3. Good health, Occupational cohort, Cohort, Female, 0305 other medical science, Risk assessment, Cohort study, Adult, medicine.medical_specialty, MESH: Socioeconomic Factors, MESH: Health Behavior, Non-response to follow-up, Physical examination, 03 medical and health sciences, MESH: Analysis of Variance, Humans, Socioeconomic status, Partial response, Analysis of Variance, 030505 public health, MESH: Humans, business.industry, MESH: Questionnaires, Methodology, MESH: Adult, Health Surveys, MESH: Male, Socioeconomic Factors, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, MESH: Female, Demography
Abstract: International audience; BACKGROUND: Little is known about the associations between non-response to follow-up surveys and mortality, or differences in these associations by socioeconomic position in studies with repeat data collections. METHODS: The Whitehall II study of socioeconomic inequalities in health provided response status from five data collection surveys; Phase 1 (1985-88, n = 10 308), Phase 5 (1997-99, n = 6533), and all-cause mortality to 2006. Odd-numbered phases included a medical examination in addition to a questionnaire. RESULTS: Non-response to baseline and to follow-up phases that included a medical examination was associated with a doubling of the mortality hazard in analyses adjusted for age and sex. Compared with complete responders, responders who missed one or more phases, but completed the last possible phase before they died, had a 38% excess risk of mortality. However, those who missed one or more phases including the last possible phase before death had an excess risk of 127%. There was no evidence that these associations differed by socioeconomic position. CONCLUSION: In studies with repeat data collections, non-response to follow-up is associated with the same doubling of the mortality risk as non-response to baseline; an association that is not modified by socioeconomic position.
Published: 2009
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42. A critical assessment of the prognostic value of clear cell, papillary and chromophobe histological subtypes in renal cell carcinoma: a population-based study

Author: Vincent Cloutier, Pierre I. Karakiewicz, Elie Antebi, Francesco Montorsi, Shahrokh F. Shariat, Claudio Jeldres, Jean Jacques Patard, Laurent Zini, Hendrik Isbarn, Paul Perrotte, Umberto Capitanio, Department of urology, Università Vita-Salute San Raffaele, Cancer Prognostics and Health Outcome Unit, Université de Montréal (UdeM), Cancer Prognostics and Health Outcomes Unit, Martini-Clinic, Prostate Cancer Center Hamburg-Eppendorf, Institut de Génétique et Développement de Rennes (IGDR), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS), Service d'urologie [Rennes] = Urology [Rennes], Hôpital Pontchaillou-CHU Pontchaillou [Rennes], Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), De Villemeur, Hervé, Capitanio, Umberto, Cloutier, Vincent, Zini, Laurent, Isbarn, Hendrik, Jeldres, Claudio, Shariat Shahrokh, F., Perrotte, Paul, Antebi, Elie, Patard Jean, Jacque, Montorsi, Francesco, and Karakiewicz Pierre, I.
Subjects: Oncology, Male, Pathology, MESH: Carcinoma, Papillary, medicine.medical_treatment, 030232 urology & nephrology, Chromophobe cell, MESH: Epidemiologic Methods, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, MESH: Cause of Death, 0302 clinical medicine, MESH: Aged, 80 and over, Renal cell carcinoma, Cause of Death, MESH: Child, Child, Aged, 80 and over, MESH: Aged, education.field_of_study, MESH: Middle Aged, MESH: Neoplasm Staging, MESH: Carcinoma, Renal Cell, Middle Aged, Prognosis, Nephrectomy, Kidney Neoplasms, 3. Good health, MESH: Young Adult, 030220 oncology & carcinogenesis, Child, Preschool, Female, Adult, medicine.medical_specialty, Adolescent, Urology, Population, [SDV.CAN]Life Sciences [q-bio]/Cancer, MESH: Prognosis, 03 medical and health sciences, Young Adult, [SDV.CAN] Life Sciences [q-bio]/Cancer, Internal medicine, medicine, Carcinoma, Humans, education, Carcinoma, Renal Cell, Aged, Neoplasm Staging, MESH: Adolescent, MESH: Humans, Proportional hazards model, business.industry, MESH: Child, Preschool, MESH: Adult, medicine.disease, [SDV.MHEP.UN] Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, Carcinoma, Papillary, MESH: Male, MESH: Kidney Neoplasms, business, Epidemiologic Methods, Kidney cancer, MESH: Female, Clear cell
Abstract: International audience; OBJECTIVE To assess the magnitude of the effect of histological subtype (HS, the three most common being clear cell, papillary and chromophobe) on cause-specific mortality (CSM) from renal cell carcinoma (RCC). PATIENTS AND METHODS Univariable and multivariable Cox regression models included data from 11 618 patients treated with nephrectomy between 1988 and 2004 in nine Surveillance Epidemiology and End Results registries. We tested whether HS represents an independent predictor of CSM, and whether HS adds to the ability of other variables to predict CSM. The covariates comprised age, year of surgery, T stage, nodal status, M stage and Fuhrman grade. RESULTS In a multivariable model predicting CSM, HS was an independent predictor (P = 0.03), but failed to improve the accuracy of the model (+0.1% gain when HS was included in the model). CONCLUSION Although we confirmed that HS is an independent predictor for CSM, there was no gain in accuracy when HS was added to standard predictors of CSM. From a practical perspective, this implies that patients with clear cell, papillary and chromophobe HS share similar natural histories after nephrectomy, provided that other cancer characteristics are accounted for. From a statistical perspective, in multivariable models of CSM, the clear cell, papillary and chromophobe HS might be included as a single entity.
Published: 2009
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43. Epidemiology, management, and risk factors for death of invasive Candida infections in critical care: a multicenter, prospective, observational study in France (2005-2006)

Author: Leroy , Olivier, Gangneux , Jean-Pierre, Montravers , Philippe, Mira , Jean-Paul, Gouin , François, Sollet , Jean-Pierre, Carlet , Jean, Reynes , Jacques, Rosenheim , Michel, Regnier , Bernard, Lortholary , Olivier, Renseigné , Non, Service de Réanimation Médicale et des Maladies Infectieuses, Centre Hospitalier Gustave Dron, Signalisation et Réponses aux Agents Infectieux et Chimiques ( SeRAIC ), Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -IFR140, Régulations des équilibres fonctionnels du foie normal et pathologique, Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -IFR140-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Département anesthésie-réanimation chirurgicale, Assistance publique - Hôpitaux de Paris (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Institut Cochin ( UMR_S567 / UMR 8104 ), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives, Université de Nantes ( UN ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Centre hospitalier universitaire de Nantes ( CHU Nantes ), service de réanimation polyvalente, Centre Hospitalier Victor Dupuy, Réanimation Médico-Chirurgicale, Groupe Hospitalier Paris Saint-Joseph, Centre d'infectiologie Necker-Pasteur [CHU Necker], CHU Necker - Enfants Malades [AP-HP]-Assistance publique - Hôpitaux de Paris (AP-HP), Mycologie moléculaire, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique ( CNRS ), Signalisation et Réponses aux Agents Infectieux et Chimiques (SeRAIC), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut Cochin (UMR_S567 / UMR 8104), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Physiopathologie des Adaptations Nutritionnelles (PhAN), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre hospitalier universitaire de Nantes (CHU Nantes), Institut Pasteur [Paris]-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Université de Rennes (UR), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Recherche Agronomique (INRA)-Université de Nantes (UN), Groupe Hospitalier Paris Saint-Joseph (hpsj), Institut Pasteur [Paris] (IP)-CHU Necker - Enfants Malades [AP-HP], Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-IFR140, Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-IFR140-Institut National de la Santé et de la Recherche Médicale (INSERM), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5), Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Necker - Enfants Malades [AP-HP], and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1)
Subjects: Male, critically ill, MESH : Aged, MESH : Prospective Studies, Critical Care and Intensive Care Medicine, 0302 clinical medicine, Case fatality rate, Hospital Mortality, Prospective Studies, MESH: Incidence, Fungemia, MESH: Treatment Outcome, Cause of death, Aged, 80 and over, Cross Infection, 0303 health sciences, MESH: Middle Aged, Incidence, Candidiasis, MESH: Follow-Up Studies, MESH : Incidence, 3. Good health, Survival Rate, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, MESH: Young Adult, MESH: Critical Illness, MESH : Intensive Care Units, MESH : Cross Infection, medicine.medical_specialty, MESH: Probability, Critical Illness, MESH : Young Adult, MESH : Cohort Studies, Statistics, Nonparametric, MESH : Hospital Mortality, 03 medical and health sciences, MESH: Critical Care, MESH: Fungemia, Intensive care, MESH : Adolescent, Humans, MESH : Middle Aged, MESH: Hospital Mortality, MESH : Aged, 80 and over, Mycosis, Aged, MESH: Adolescent, MESH: Humans, 030306 microbiology, MESH : Humans, MESH: Adult, MESH : Follow-Up Studies, MESH: Antifungal Agents, medicine.disease, chemistry, MESH: Female, Fluconazole, Antifungal Agents, MESH : Critical Illness, Cohort Studies, MESH: Cause of Death, chemistry.chemical_compound, MESH : Candidiasis, MESH: Aged, 80 and over, Risk Factors, MESH: Risk Factors, [ SDV.MP ] Life Sciences [q-bio]/Microbiology and Parasitology, Cause of Death, MESH : Female, 030212 general & internal medicine, MESH: Cohort Studies, MESH : Critical Care, Candida, intensive care, MESH: Aged, MESH: Statistics, Nonparametric, fungemia, Middle Aged, MESH : Adult, MESH : Survival Rate, MESH : Risk Factors, MESH: Candidiasis, Intensive Care Units, Treatment Outcome, Female, epidemiology, France, medicine.drug, Adult, Adolescent, Critical Care, MESH: Survival Rate, MESH : Male, MESH : Probability, MESH : Antifungal Agents, MESH : Treatment Outcome, Young Adult, Internal medicine, medicine, MESH : France, MESH : Statistics, Nonparametric, Probability, MESH : Cause of Death, Voriconazole, business.industry, MESH: Cross Infection, MESH: Male, MESH: Prospective Studies, Surgery, MESH: France, MESH : Fungemia, MESH: Intensive Care Units, Caspofungin, business, Follow-Up Studies
Abstract: International audience; OBJECTIVE: To describe the evolving epidemiology, management, and risk factors for death of invasive Candida infections in intensive care units (ICUs). DESIGN: Prospective, observational, national, multicenter study. SETTING: One hundred eighty ICUs in France. PATIENTS: Between October 2005 and May 2006, 300 adult patients with proven invasive Candida infection who received systemic antifungal therapy were included. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: One hundred seven patients (39.5%) with isolated candidemia, 87 (32.1%) with invasive candidiasis without documented candidemia, and 77 (28.4%) with invasive candidiasis and candidemia were eligible. In 37% of the cases, candidemia occurred within the first 5 days after ICU admission. C. albicans accounted for 57.0% of the isolates, followed by C. glabrata (16.7%), C. parapsilosis (7.5%), C. krusei (5.2%), and C. tropicalis (4.9%). In 17.1% of the isolates, the causative Candida was less susceptible or resistant to fluconazole. Fluconazole was the empirical treatment most commonly introduced (65.7%), followed by caspofungin (18.1%), voriconazole (5.5%), and amphotericin B (3.7%). After identification of the causative species and susceptibility testing results, treatment was modified in 86 patients (31.7%). The case fatality ratio in ICU was 45.9% and did not differ significantly according to the type of episode. Multivariate analysis showed that factors independently associated with death in ICU were type 1 diabetes mellitus (odds ratio [OR] 4.51; 95% confidence interval [CI] 1.72-11.79; p = 0.002), immunosuppression (OR 2.63; 95% CI 1.35-5.11; p = 0.0045), mechanical ventilation (OR 2.54; 95% CI 1.33-4.82; p = 0.0045), and body temperature >38.2 degrees C (reference, 36.5-38.2 degrees C; OR 0.36; 95% CI 0.17-0.77; p = 0.008). CONCLUSIONS: More than two thirds of patients with invasive candidiasis in ICU present with candidemia. Non-albicans Candida species reach almost half of the Candida isolates. Reduced susceptibility to fluconazole is observed in 17.1% of Candida isolates. Mortality of invasive candidiasis in ICU remains high.
Published: 2009
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44. Immediate listing for liver transplantation versus standard care for Child-Pugh stage B alcoholic cirrhosis: a randomized trial

Author: Claire Vanlemmens, Vincent Di Martino, Chantal Milan, Michel Messner, Anne Minello, Christophe Duvoux, Poynard, Jean-Marc Perarnau, Marie-Anne Astrid Piquet, Georges-Philippe Pageaux, Sébastien Dharancy, Christine Silvain, Sophie Hillaire, Gérard Thiefin, Jean-Pierre Vinel, Patrick Hillon, Estelle Collin, Georges Mantion, Jean-Philippe Miguet, Non Renseigné, Humbert, Murielle, Service d'Hépato-Gastroentérologie [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Pitié-Salpêtrière [APHP], Agents pathogènes et inflammation - UFC (EA 4266) ( API ), Université de Franche-Comté ( UFC ), Lipides - Nutrition - Cancer (U866) ( LNC ), Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon ( ENSBANA ), Université de Lille, Droit et Santé, Hôpital Duriez, Service des Maladies de l'Appareil digestif et de la Nutrition, Centre Hospitalier Régional Universitaire [Lille] ( CHRU Lille ), Institut de médecine moléculaire de Rangueil ( I2MR ), Université Paul Sabatier - Toulouse 3 ( UPS ) -IFR31-IFR150-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Service de Gastro-entérologie et Nutrition[Rangueil], CHU Toulouse [Toulouse]-Hôpital de Rangueil, Service d'Hépato-Gastroentérologie, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand ( CHU Dijon ) -Hôpital du Bocage, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand ( CHU Dijon ), WHO Collaborating Center on Prevention and Treatment of Human Echinococcosis, Service d'Hépato-Gastro-Entérologie [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Agents pathogènes et inflammation - UFC (EA 4266) (API), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Lipides - Nutrition - Cancer (U866) (LNC), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon (ENSBANA), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Institut de médecine moléculaire de Rangueil (I2MR), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-IFR150-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Toulouse [Toulouse], Service d'hépato-gastroentérologie et cancérologie digestive (CHU de Dijon), and Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon)
Subjects: Male, Alcoholic liver disease, Time Factors, medicine.medical_treatment, MESH : Aged, Liver transplantation, Severity of Illness Index, MESH: Cause of Death, MESH: Risk Factors, Liver Cirrhosis, Alcoholic, Risk Factors, Cause of Death, Neoplasms, MESH: Neoplasms, MESH : Female, MESH: Treatment Outcome, MESH: Aged, [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, MESH: Middle Aged, MESH: Liver Cirrhosis, Alcoholic, Standard treatment, Hazard ratio, General Medicine, Middle Aged, MESH : Adult, MESH : Risk Factors, Treatment Outcome, MESH: Waiting Lists, MESH: Young Adult, MESH: Survival Analysis, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Female, MESH : Severity of Illness Index, France, MESH : Waiting Lists, MESH : Time Factors, Adult, MESH: Liver Transplantation, medicine.medical_specialty, Adolescent, Waiting Lists, MESH : Male, MESH : Young Adult, Alcoholic hepatitis, MESH : Treatment Outcome, [ SDV.MP.VIR ] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Young Adult, MESH: Severity of Illness Index, Internal medicine, MESH : Adolescent, Internal Medicine, medicine, Humans, MESH : Middle Aged, MESH : France, Survival rate, Contraindication, Aged, MESH : Cause of Death, MESH: Adolescent, MESH: Humans, business.industry, MESH: Time Factors, MESH : Humans, MESH: Adult, MESH : Liver Cirrhosis, Alcoholic, medicine.disease, Survival Analysis, MESH : Neoplasms, MESH: Male, Surgery, Liver Transplantation, MESH: France, Transplantation, MESH : Survival Analysis, MESH : Liver Transplantation, business, MESH: Female
Abstract: International audience; BACKGROUND: Liver transplantation improves survival of patients with end-stage (Child-Pugh stage C) alcoholic cirrhosis, but its benefit for patients with stage B disease is uncertain. OBJECTIVE: To compare the outcomes of patients with Child-Pugh stage B alcoholic cirrhosis who are immediately listed for liver transplantation with those of patients assigned to standard treatment with delay of transplantation until progression to stage C disease. DESIGN: Randomized, controlled trial. SETTING: 13 liver transplantation programs in France. PATIENTS: 120 patients with Child-Pugh stage B alcoholic cirrhosis and no viral hepatitis, cancer, or contraindication to transplantation. INTERVENTIONS: Patients were randomly assigned to immediate listing for liver transplantation (60 patients) or standard care (60 patients). MEASUREMENTS: Overall and cancer-free survival over 5 years. RESULTS: Sixty-eight percent of patients assigned to immediate listing for liver transplantation and 25% of those assigned to standard care received a liver transplant. All-cause death and cirrhosis-related death did not statistically differ between the 2 groups: 5-year survival was 58% (95% CI, 43% to 70%) for those assigned to immediate listing versus 69% (CI, 54% to 80%) for those assigned to standard care. In multivariate analysis, independent predictors of long-term survival were absence of ongoing alcohol consumption (hazard ratio, 7.604 [CI, 2.395 to 24.154]), recovery from Child-Pugh stage C (hazard ratio, 7.633 [CI, 2.392 to 24.390]), and baseline Child-Pugh score less than 8 (hazard ratio, 2.664 [CI, 1.052 to 6.746]). Immediate listing for transplantation was associated with an increased risk for extrahepatic cancer: The 5-year cancer-free survival rate was 63% (CI, 43% to 77%) for patients who were immediately listed and 94% (CI, 81% to 98%) for those who received standard care. LIMITATION: Restriction of the study sample to alcoholic patients may limit the generalizability of results to other settings. CONCLUSION: Immediate listing for liver transplantation did not show a survival benefit compared with standard care for Child-Pugh stage B alcoholic cirrhosis. In addition, immediate listing for transplantation increased the risk for extrahepatic cancer. FUNDING: The French National Program for Clinical Research.
Published: 2009

45. Cardiorespiratory risk factors as predictors of 40-year mortality in women and men

Author: Ferrie, Jane, Singh-Manoux, Archana, Kivimaki, Mika, Mindell, Jennifer, Breeze, Elizabeth, Davey Smith, George, Shipley, Martin, Kaniewski, Nadine, Department of Epidemiology and Public Health, University College of London [London] (UCL), Santé publique et épidémiologie des déterminants professionnels et sociaux de la santé, Epidémiologie, sciences sociales, santé publique (IFR 69), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Social Medicine, and University of Bristol [Bristol]
Subjects: MESH: Aged, MESH: Smoking, MESH: Middle Aged, MESH: Humans, MESH: Heart Diseases, MESH: Adult, MESH: Respiratory Function Tests, MESH: Blood Pressure, MESH: Male, MESH: Body Mass Index, MESH: Cause of Death, 1960s, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Risk Factors, risk factors, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, 40-year mortality, MESH: Respiratory Tract Diseases, MESH: Cohort Studies, MESH: Female, cardiorespiratory mortality
Abstract: International audience; OBJECTIVE: Most historical studies of cardiorespiratory risk factors as predictors of mortality have been based on men. This study examines whether they predict mortality over long periods in women and men. DESIGN: Prospective cohort study. SETTING: Participants were employees of the General Post Office. METHODS: Risk factor data were collected via clinical examination and questionnaire, 1966-7. Associations between cardiorespiratory risk factors and 40-year mortality were determined for 644 women and 1272 men aged 35-70 at examination. MAIN OUTCOME MEASURES: All-cause, cardiovascular (CVD), cancer and respiratory mortality. RESULTS: Associations between systolic blood pressure and all-cause and stroke mortality were equally strong for women and men, hazard ratio (95% confidence interval) 1.25 (1.1 to 1.4) and 1.18 (1.1 to 1.3); and 2.17 (1.7 to 2.8) and 1.69 (1.4 to 2.1), respectively. Cholesterol was higher in women and was associated with all-cause 1.22 (1.1 to 1.4) and CVD 1.39 (1.2 to 1.7) mortality, while associations between 2-hour glucose and all-cause 1.15 (1.1 to 1.2), coronary heart disease (CHD) 1.25 (1.1 to 1.4) and respiratory mortality 1.21 (1.0 to 1.5) were observed in men. Obesity was associated with stroke in women (2.42 (1.12 to 5.24)) and CHD in men (1.59 (1.02 to 2.49)), while ECG ischaemia was associated with CVD in both sexes. The strongest, most consistent predictor of mortality was smoking in women and poor lung function in men. However, evidence of sex differences in associations between the cardiorespiratory risk factors measured and mortality was sparse. CONCLUSIONS: Data from a 40-year follow-up period show remarkably persistent associations between risk factors and cardiorespiratory and all-cause mortality in women and men.
Published: 2009
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46. Survival in patients with uveal melanoma in Europe

Author: Maria Cecilia Cercato, Pascale Grosclaude, Michel Coleman, Laura Ciccolallo, Mariano Santaquilani, Valerio Ramazzotti, Emanuele Crocetti, Stefano Ferretti, Gemma Gatta, Gianni Virgili, Laufey Tryggvadottir, Franco Berrino, Hans Storm, Paolo Baili, Evaluative Epidemiology Unit, Fondazione IRCCS, Department of Statistics 'G. Parenti', University of Florence and Biostatistics Unit ISPO (Institute for Cancer Prevention and Research), Registre Genevois des Tumeurs, CHU Genève, Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC ( CEF2P / CARCINO ), Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ) -Université Bourgogne Franche-Comté ( UBFC ) -Université de Franche-Comté ( UFC ), Università degli Studi di Firenze = University of Florence [Firenze] (UNIFI), Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (EA 3181) (CEF2P / CARCINO), Université de Franche-Comté (UFC), and Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)
Subjects: Male, MESH : Retrospective Studies, MESH : Aged, MESH: Risk Assessment, [ SDV.CAN ] Life Sciences [q-bio]/Cancer, 0302 clinical medicine, 80 and over, MESH: Incidence, Melanoma, Cause of death, Aged, 80 and over, MESH: Middle Aged, Incidence, MESH: Sex Distribution, Prognosis, MESH : Incidence, MESH: International Classification of Diseases, 3. Good health, MESH : Uveal Neoplasms, 030220 oncology & carcinogenesis, Cohort study, medicine.medical_specialty, MESH: Melanoma, MESH: Probability, Survival - uveal melanoma - Europe, Socio-culturale, MESH : Cohort Studies, Risk Assessment, MESH: Prognosis, Disease-Free Survival, Europe/epidemiology, 03 medical and health sciences, Uveal Neoplasms/diagnosis/mortality/therapy, MESH : Adolescent, MESH : International Classification of Diseases, Humans, Melanoma/diagnosis/mortality/therapy, MESH : Middle Aged, MESH : Aged, 80 and over, MESH: Age Distribution, Survival analysis, Aged, Retrospective Studies, MESH: Adolescent, MESH: Humans, MESH : Humans, MESH: Adult, MESH: Retrospective Studies, Survival Analysis, Cancer registry, Ophthalmology, MESH: Disease-Free Survival, 030221 ophthalmology & optometry, MESH: Female, Uveal Neoplasms, MESH: Registries, MESH : Age Distribution, MESH : Analysis of Variance, MESH: Cause of Death, Cohort Studies, MESH: Aged, 80 and over, Cause of Death, MESH : Female, Registries, MESH : Risk Assessment, MESH: Cohort Studies, MESH : Sex Distribution, MESH: Aged, MESH : Prognosis, Relative survival, Incidence (epidemiology), Absolute risk reduction, Middle Aged, MESH : Adult, Europe, MESH: Survival Analysis, MESH : Disease-Free Survival, Female, Adult, Adolescent, MESH : Male, MESH : Probability, MESH : Europe, MESH : Melanoma, [SDV.CAN]Life Sciences [q-bio]/Cancer, Age Distribution, Analysis of Variance, International Classification of Diseases, Multivariate Analysis, Probability, Sex Distribution, MESH: Multivariate Analysis, MESH: Analysis of Variance, Internal medicine, medicine, ddc:613, MESH : Cause of Death, business.industry, MESH : Multivariate Analysis, Retrospective cohort study, MESH: Male, Surgery, MESH: Uveal Neoplasms, MESH: Europe, MESH : Survival Analysis, business, MESH : Registries
Abstract: International audience; OBJECTIVE: To estimate survival in patients in whom uveal melanoma was diagnosed between January 1, 1983, and December 31, 1994, in Europe. METHODS: Survival analysis of data from 32 cancer registries in 16 European countries adhering to the European Cancer Registry for 5788 patients with uveal melanoma diagnosed between January 1, 1983, and December 31, 1994, with follow-up to 1999. RESULTS: Five-year relative survival was 68.9% overall and remained stable with the period of diagnosis. Relative excess risk of death was 2.45 (95% confidence interval [CI], 2.10-2.86) in patients aged 75 years or older compared with patients aged 54 years or younger and was slightly higher in male patients (relative excess risk, 1.10; 95% CI, 1.02-1.19) than in female patients. Survival was similar in Nordic countries (relative excess risk, 1.03; 95% CI, 0.87-1.21) compared with the United Kingdom (reference country) and was lower in eastern and western European countries (1.26; 1.05-1.52, and 1.25; 0.90-1.60, respectively) compared with the reference country. CONCLUSIONS: In this large series of patients with uveal melanoma, 5-year relative survival remained stable with the introduction of conservative treatment in individuals in whom uveal melanoma was diagnosed between 1983 and 1994. We found differences in survival between sexes and in European areas that should be investigated in studies that consider tumor characteristics at the individual level.
Published: 2008
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47. Asthma-related mortality in France, 1980-2005: decline since the last decade

Author: P. Godard, Isabella Annesi-Maesano, Jean-Pierre Piau, Jean Bousquet, S. Tual, Epidémiologie des maladies infectieuses et modélisation (ESIM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Tual S, P Godard, JP Piau, Bousquet J, and Annesi-Maesano je .
Subjects: Adult, Male, MESH: Asthma, Immunology, MEDLINE, Death Certificates, MESH: Cause of Death, Age Distribution, Risk Factors, Environmental protection, MESH: Risk Factors, Cause of Death, Environmental health, Asthma mortality, Humans, Immunology and Allergy, Medicine, Mortality, Sex Distribution, Mortality trends, MESH: Age Distribution, ComputingMilieux_MISCELLANEOUS, Aged, Asthma, Cause of death, MESH: Aged, MESH: Middle Aged, MESH: Humans, MESH: Mortality, business.industry, MESH: Sex Distribution, MESH: Adult, Middle Aged, medicine.disease, MESH: Male, MESH: France, MESH: Death Certificates, Female, Age distribution, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, France, business, MESH: Female
Abstract: International audience
Published: 2008
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48. Biomarkers of inflammation and malnutrition associated with early death in healthy elderly people

Author: Carriere, Isabelle, Dupuy, Anne-Marie, Lacroux, Annie, Cristol, Jean-Paul, Delcourt, Cécile, Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC), Université Montpellier 1 (UM1)-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Département de biochimie [Montpellier], Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Lapeyronie, Equipe associée, Université Montpellier 1 (UM1), Épidémiologie et prévention : environnement et efficacité des interventions (EPIPREV), Epidémiologie, santé publique et développement, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR99-ISPED, Fondation de France, Fondation pour la recherche Médicale, Région Languedoc-Roussillon, Association Retina France, Rhones Poulenc, Essilor, Specia, Horiba ABX Montpellier, Centre de Recherche et d'Information Nutritionnelle, Villebrun, Dominique, and Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)
Subjects: Male, MESH: Risk Assessment, MESH: Proportional Hazards Models, MESH: Cause of Death, MESH: Health Surveys, MESH: Aged, 80 and over, MESH: Cholesterol, Reference Values, Cause of Death, Neoplasms, Prealbumin, MESH: Neoplasms, Prospective Studies, Aged, 80 and over, MESH: Aged, MESH: Middle Aged, [SDV.MHEP.GEG] Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontology, [SDV.MHEP.GEG]Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontology, Age Factors, MESH: Reference Values, Orosomucoid, MESH: Follow-Up Studies, Middle Aged, C-Reactive Protein, Cholesterol, Cardiovascular Diseases, MESH: Orosomucoid, Female, France, Inflammation Mediators, MESH: Inflammation Mediators, MESH: Serum Albumin, Protein-Energy Malnutrition, Risk Assessment, Article, Sex Factors, MESH: Sex Factors, MESH: Prealbumin, MESH: C-Reactive Protein, Humans, Serum Albumin, Aged, Proportional Hazards Models, MESH: Age Factors, MESH: Humans, MESH: Cardiovascular Diseases, Health Surveys, MESH: Male, MESH: Prospective Studies, MESH: Protein-Energy Malnutrition, MESH: France, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Female, Follow-Up Studies
Abstract: International audience; OBJECTIVES: To determine whether malnutrition and biomarkers of inflammation predict all-cause, cancer, and cardiovascular mortality in healthy elderly subjects. DESIGN: Population-based study, prospective cohort. SETTING: S?, on the French Mediterranean coast. PARTICIPANTS: Five hundred and fifty-three men and 888 women aged 60 and older from the Pathologies Oculaires Li? ?'Age cohort free of known comorbidities. MEASUREMENTS: Plasma levels of cholesterol, albumin, transthyretin (TTR), C-reactive protein (CRP), and alpha 1-acid glycoprotein (AAG) were measured at baseline. To investigate the risks of 5-year (early) and 5- to 9-year (late) mortality, hazard ratios (HR) were evaluated using Cox models. RESULTS: In men, early death was associated with high CRP and AAG and low albumin and TTR. In women, early death was associated with high AAG, low TTR and low cholesterol. For late death, the only significant association was with CRP in men. A synergistic effect was observed between biomarkers of inflammation and malnutrition. In men, the adjusted HR of early death was 4.98 (95% confidence interval (CI)=2.25-11.01) for both CRP in the highest quartile and albumin in the lowest. In men, this risk was greatest for both AAG in the highest quartile and TTR in the lowest (HR=6.86, 95% CI=3.20-14.71). In women, this risk was greatest for both AAG in the highest quartile and TTR in the lowest (HR=4.64, 95% CI=1.79-12.05). Cancer mortality was greater for high CRP and AAG and for low albumin and TTR in men but not in women. CONCLUSION: Biomarkers of inflammation and malnutrition together predict early mortality. In healthy elderly subjects, TTR and AAG could be helpful in identifying elderly subjects at higher risk of death.
Published: 2008
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49. Neglected psychiatric comorbidity in people with epilepsy in developing countries--response to Tellez-Zenteno et al

Author: Pierre-Marie Preux, Mitchell G. Weiss, Peter Odermatt, Victor Doku, Swiss Tropical Institute (STI), Department Public Health and Epidemiology, Neuroépidémiologie Tropicale et Comparée (NETEC), Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503)-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Université de Limoges (UNILIM), Laboratoire de Biostatistique et d'Informatique Médicale, Université de Limoges (UNILIM), Service de l'Information Médicale et de l'Évaluation [CHU Limoges] (SIME), CHU Limoges, Kintampo Surveillance Demographic System, and Kintampo Health Research Centre, Ghana
Subjects: medicine.medical_specialty, MESH: Poverty, 030231 tropical medicine, MESH: Depressive Disorder, MESH: Delivery of Health Care, Poison control, Developing country, MESH: Comorbidity, Suicide prevention, Occupational safety and health, MESH: Cause of Death, 03 medical and health sciences, Epilepsy, 0302 clinical medicine, Injury prevention, Medicine, MESH: Mental Disorders, Psychiatry, MESH: Developing Countries, ComputingMilieux_MISCELLANEOUS, MESH: Prevalence, MESH: Humans, business.industry, MESH: Research Design, Human factors and ergonomics, medicine.disease, Comorbidity, MESH: Suicide, Neurology, MESH: Epilepsy, MESH: Anxiety Disorders, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Neurology (clinical), Medical emergency, business, 030217 neurology & neurosurgery
Abstract: International audience
Published: 2008
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50. Association of physical job demands, smoking and alcohol abuse with subsequent premature mortality: a 9-year follow-up population-based study

Author: Francis Guillemin, Carmen Otero Sierra, N. Massin, Nearkasen Chau, Lahoucine Benamghar, Jean-Marc Fontana, J.P. Meyer, Pascal Wild, Jean-Marie Mur, Eve Bourgkard, Jean-François Ravaud, Département épidémiologie en entreprise (EE), Institut national de recherche et de sécurité (Vandoeuvre lès Nancy) (INRS ( Vandoeuvre lès Nancy)), WHO Collaborative centre, World Health Organization (WH0), Département Homme au Travail (HT), Epidémiologie, santé, travail, Institut National de la Santé et de la Recherche Médicale (INSERM), CERMES - Centre de recherche Médecine, Science, Santé Société (CERMES - UMR 8169 / U750), Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Faculté de Médecine [Nancy], Université de Lorraine (UL), Troubles du comportement alimentaire de l'adolescent (UMR_S 669), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Sud - Paris 11 (UP11), Ravaud, Jean-François, Centre de recherche Médecine, Science, Santé et Société (CERMES), Université Paris-Sud - Paris 11 (UP11) - École des hautes études en sciences sociales (EHESS) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Centre National de la Recherche Scientifique (CNRS), Université Paris Descartes - Paris 5 (UPD5) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Université Paris-Sud - Paris 11 (UP11), and Université Paris-Sud - Paris 11 (UP11)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: Male, Health Status, Alcohol abuse, Poison control, MESH: Cause of Death, MESH: Health Surveys, Cause of Death, Work Schedule Tolerance, Odds Ratio, Longitudinal Studies, MESH: Longitudinal Studies, MESH: Workload, MESH: Health Status, MESH: Aged, education.field_of_study, MESH: Middle Aged, Mortality rate, Smoking, MESH: Follow-Up Studies, Middle Aged, Occupational Diseases, Alcoholism, symbols, Female, Medical emergency, France, Adult, MESH: Occupational Diseases, MESH: Smoking, MESH: Socioeconomic Factors, Adolescent, Population, Workload, symbols.namesake, MESH: Alcoholism, Injury prevention, medicine, Humans, Poisson regression, Mortality, education, Aged, MESH: Work Schedule Tolerance, MESH: Adolescent, MESH: Humans, MESH: Mortality, business.industry, Public Health, Environmental and Occupational Health, MESH: Adult, Odds ratio, medicine.disease, Health Surveys, MESH: Male, MESH: Odds Ratio, MESH: France, Socioeconomic Factors, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Relative risk, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, MESH: Female, Demography, Follow-Up Studies
Abstract: International audience; This study assessed the relationships of physical job demands (PJD), smoking, and alcohol abuse, with premature mortality before age 70 (PM-70) among the working or inactive population. The sample included 4,268 subjects aged 15 or more randomly selected in north-eastern France. They completed a mailed questionnaire (birth date, sex, weight, height, job, PJD, smoking habit, alcohol abuse (Deta questionnaire)) in 1996 and were followed for mortality until 2004 (9 yr). PJD score was defined by the cumulative number of the following high job demands at work: hammer, vibrating platform, pneumatic tools, other vibrating hand tools, screwdriver, handling objects, awkward posture, tasks at heights, machine tools, pace, working on a production line, standing about and walking. The data were analyzed using the Poisson regression model. Those with PM-70 were 126 (3.81 per 1,000 person-years). The leading causes of death were cancers (46.4% in men, 57.1% in women), cardiovascular diseases (20.2% and 11.9%), suicide (9.5% and 7.1%), respiratory diseases (6.0% and 4.8%), and digestive diseases (2.4% and 4.8%). PJD3, smoker, and alcohol abuse had adjusted risk ratios of 1.71 (95% CI 1.02-2.88), 1.76 (1.08-2.88), and 2.07 (1.31-3.26) respectively for all-cause mortality. Manual workers had a risk ratio of 1.84 (1.00-3.37) compared to the higher socio-economic classes. The men had a two-fold higher mortality rate than the women; this difference became non-significant when controlling for job, PJD, smoker and alcohol abuse. For cancer mortality the factors PJD3, smoker, and alcohol abuse had adjusted risk ratios of 2.00 (1.00-3.99), 2.34 (1.19-4.63), and 2.22 (1.17-4.20), respectively. Health promotion efforts should be directed at structural measures of task redesign and they should also concern lifestyle.
Published: 2008

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