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8 results on '"MESH: Aphasia"'

1. Aphasia outcome: the interactions between initial severity, lesion size and location

Author

Céline Arbizu, Yves Samson, Anne Leger, Christine Pires, Sarah Benghanem, Eric A. Moulton, Charlotte Rosso, Didier Dormont, CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Hôpital Raymond Poincaré [AP-HP], Algorithms, models and methods for images and signals of the human brain (ARAMIS), Sorbonne Université (SU)-Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Service des Urgences Cérébro-Vasculaires [CHU Pitié-Salpétriêre], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Service d'Urgences Cérébro-Vasculaires [CHU Pitié-Salpêtrière], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)

Subjects
Male, Multivariate analysis, Neurology, MESH: Echo-Planar Imaging, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Severity of Illness Index, 0302 clinical medicine, 030212 general & internal medicine, 10. No inequality, Neuroradiology, MESH: Aged, Univariate analysis, MESH: Middle Aged, medicine.diagnostic_test, Echo-Planar Imaging, MESH: Infarction, Middle Cerebral Artery, Infarction, Middle Cerebral Artery, MESH: Follow-Up Studies, Middle Aged, Prognosis, [INFO.INFO-TI]Computer Science [cs]/Image Processing [eess.IV], Cardiology, Female, medicine.symptom, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, medicine.medical_specialty, macromolecular substances, MESH: Diffusion Magnetic Resonance Imaging, behavioral disciplines and activities, MESH: Prognosis, Lesion, 03 medical and health sciences, Magnetic resonance imaging, Aphasia, Internal medicine, MESH: Severity of Illness Index, medicine, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, Humans, Aged, MESH: Aphasia, MESH: Humans, business.industry, Univariate, [INFO.INFO-CV]Computer Science [cs]/Computer Vision and Pattern Recognition [cs.CV], MESH: Male, nervous system diseases, Diffusion Magnetic Resonance Imaging, Neurology (clinical), business, MESH: Female, 030217 neurology & neurosurgery, Follow-Up Studies
Abstract

The outcome of aphasia at 3 months is variable in patients with moderate/severe stroke. The aim was to predict 3-month aphasia outcome using prediction models including initial severity in addition to the interaction between lesion size and location at the acute phase. Patients with post-stroke aphasia (assessed by the Aphasia Rapid Test at day 7-ART D7) and MRI performed at day 1 were enrolled (n = 73). Good outcome at 3-months was defined by an Aphasia Handicap Score of 0–2. Each infarct lesion was overlapped with an area of interest in the left temporo-parietal region to compute an intersection index (proportion of the critical region damaged by the infarct). We tested ART D7, age, lesion volume, and intersection index as well as a combined variable lesion volume*intersection in a univariate analysis. Then, we performed a multivariate analysis to investigate which variables were independent predictors of good outcome. ART at D7, infarct volume, and the intersection index were univariate predictors of good outcome. In the multivariate analysis, ART D7 and “volume ≥ 50 ml or intersection index ≥ 20%” correctly classified 89% of the patients (p

Published
2019
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2. Évaluation du devenir global à l’âge adulte de sujets ayant été pris en charge dans l’enfance pour trouble sévère et spécifique du langage oral et/ou du langage écrit dans l’unité spécialisée du Centre de Référence des Troubles des Apprentissages du Kremlin Bicêtre

Author

Chatriot, Inès, Université Paris Descartes - Faculté de Médecine (UPD5 Médecine), Université Paris Descartes - Paris 5 (UPD5), and Florence Delteil

Subjects
MESH: Dyslexia, Dyslexie, Trouble du langage oral, Étude longitudinale, Trouble du langage écrit, Dysphasie, MESH: Learning Disorders, Troubles des apprentissages, MESH: Language Development Disorders, MESH: Longitudinal Studies, Trouble du langage oral développemental, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, MESH: Aphasia
Abstract

Les troubles spécifiques du langage oral et écrit ont des conséquences multiples à long terme. Objectif : le but de cette étude était d’évaluer le devenir global à l’âge adulte des anciens élèves de l’Unité de Rééducation du Centre de Référence des Troubles des Apprentissages du Kremlin Bicêtre, et de comparer l’évolution des sujets avec ou sans trouble du langage oral. Méthodes : nous avons inclus consécutivement tous les sujets majeurs au moment de l’étude ayant été scolarisés dans l’unité entre septembre 2001 et septembre 2003, pour trouble sévère et spécifique du langage oral et/ou écrit. L’évolution a été évaluée à l’aide d’un questionnaire. Résultat : quarante sujets ont été inclus, 23 ont rempli le questionnaire. Vingt-cinq avaient un trouble du langage écrit sans trouble du langage oral (TLO-) et 15 avaient un trouble du langage oral (TLO+). Le niveau d’étude était égal ou supérieur au baccalauréat chez 77% des sujets TLO- et chez 40% des sujets TLO+ (non significatif). Les sujets évalués étaient peu diplômés mais évoluaient favorablement en termes d’accès à l’emploi. L’estime de soi était plus faible chez les étudiants (p

Published
2017

3. Validation of the Aphasic Depression Rating Scale

Author

Jacques Pélissier, Bruno Cailly, Charles Benaim, Dominic Pérennou, Pôle Rééducation - Réadaptation (Médecine Physique et Réadaptation) (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), CHU Grenoble, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble, Euromov (EuroMov), and Université de Montpellier (UM)

Subjects
Adult, Male, MESH: Psychiatric Status Rating Scales, medicine.medical_specialty, MESH: Depression, Visual analogue scale, medicine.medical_treatment, behavioral disciplines and activities, MESH: Stroke, 03 medical and health sciences, 0302 clinical medicine, Rating scale, Aphasia, Criterion validity, medicine, Humans, 030212 general & internal medicine, Psychiatry, Stroke, Depression (differential diagnoses), MESH: Aphasia, Aged, MESH: Aged, Psychiatric Status Rating Scales, Advanced and Specialized Nursing, MESH: Humans, MESH: Middle Aged, Rehabilitation, Depression, business.industry, [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, Construct validity, MESH: Adult, Middle Aged, medicine.disease, MESH: Male, Physical therapy, Female, Neurology (clinical), medicine.symptom, Cardiology and Cardiovascular Medicine, business, MESH: Female, 030217 neurology & neurosurgery
Abstract

Background and Purpose— The Aphasic Depression Rating Scale (ADRS) was developed to detect and measure depression in aphasic patients during the subacute stage of stroke. Methods— Six experts selected an initial sampling of behavioral items from existing depression rating scales. Stroke patients (aphasic and nonaphasic) were assessed with these items by the rehabilitation staff, with the Hamilton Depression Rating Scale (HDRS) for nonaphasic patients only, by a psychiatrist, and by the rehabilitation staff with Visual Analog Scales (VAS). A second item selection was conducted after a regression algorithm was run including VAS as independent variables (criterion validity) and after their factorial structure was analyzed with a principal component analysis (factorial validity). The construct validity was evaluated with respect to the other depression assessments. A threshold for the diagnosis of depression was computed with respect to the psychiatrist’s diagnosis. Interrater and test-retest reliability were assessed in 2 additional groups of aphasic patients. Results— Eighty patients participated in the study (59 aphasic). Fifteen behavioral items from existing depression rating scales were selected, and 9 were retained after the validation process. ADRS correlated highly with VAS and HDRS ( r =0.60 to 0.78, P =10 −4 to 10 −6 ). With respect to the psychiatrist’s diagnosis, the sensitivity and specificity of ADRS were 0.83 and 0.71, respectively, when the threshold was set at 9/32. Its factorial structure was comparable to HDRS structure. Interrater and test-retest reliability were high (average κ coefficient of the 9 items=0.69). Conclusions— ADRS is a valid, reliable, sensitive, and specific tool for the evaluation of depression in aphasic patients during the stroke subacute phase.

Published
2004
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4. The Aphasia Rapid Test: an NIHSS-like aphasia test

Author

C. Azuar, S. Chomel-Guillaume, Yves Samson, Céline Arbizu, François Henry-Amar, A. Leger, Université Paris Descartes - Faculté de Médecine (UPD5 Médecine), Université Paris Descartes - Paris 5 (UPD5), Equipe NEMESIS - Centre de Recherches de l'Institut du Cerveau et de la Moelle épinière (NEMESIS-CRICM), Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière (CRICM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Paris Descartes - Faculté de Médecine ( UPD5 Médecine ), Université Paris Descartes - Paris 5 ( UPD5 ), Equipe NEMESIS - Centre de Recherches de l'Institut du Cerveau et de la Moelle épinière ( NEMESIS-CRICM ), Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière ( CRICM ), Centre National de la Recherche Scientifique ( CNRS ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Centre National de la Recherche Scientifique ( CNRS ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ), and Colliot, Olivier

Subjects
Male, Neurology, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, [INFO.INFO-IM] Computer Science [cs]/Medical Imaging, MESH : Aged, MESH: Logistic Models, Neuropsychological Tests, [ INFO.INFO-CV ] Computer Science [cs]/Computer Vision and Pattern Recognition [cs.CV], MESH: Observer Variation, Disability Evaluation, 0302 clinical medicine, [INFO.INFO-CV] Computer Science [cs]/Computer Vision and Pattern Recognition [cs.CV], [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging, Neuroradiology, MESH: Treatment Outcome, Aged, 80 and over, Original Communication, MESH: Middle Aged, [ INFO.INFO-IM ] Computer Science [cs]/Medical Imaging, MESH: Speech, MESH: Disability Evaluation, MESH: Follow-Up Studies, MESH: Reproducibility of Results, [INFO.INFO-TI] Computer Science [cs]/Image Processing [eess.IV], Predictive value of tests, [ SDV.NEU.NB ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, MESH: Language, 0305 other medical science, medicine.medical_specialty, Point-of-Care Systems, MESH: Dysarthria, MESH : Disability Evaluation, MESH: Psychomotor Performance, behavioral disciplines and activities, MESH: Stroke, 03 medical and health sciences, MESH : Verbal Behavior, Aphasia, Humans, MESH : Middle Aged, MESH : Predictive Value of Tests, MESH : Aged, 80 and over, Aged, Acute stroke, [SPI.SIGNAL] Engineering Sciences [physics]/Signal and Image processing, MESH: Aphasia, MESH: Verbal Behavior, MESH: Humans, Verbal Behavior, MESH : Reproducibility of Results, MESH : Humans, MESH : Follow-Up Studies, MESH : Observer Variation, MESH : Psychomotor Performance, MESH: ROC Curve, MESH : Point-of-Care Systems, Logistic Models, Neurology (clinical), MESH: Female, Psychomotor Performance, 030217 neurology & neurosurgery, MESH : Logistic Models, 030506 rehabilitation, MESH : Stroke, [ SPI.SIGNAL ] Engineering Sciences [physics]/Signal and Image processing, MESH: Aged, 80 and over, [ INFO.INFO-TI ] Computer Science [cs]/Image Processing, MESH : Female, MESH : Dysarthria, Language, Observer Variation, MESH : Aphasia, MESH: Aged, Follow up studies, Functional recovery, MESH: Neuropsychological Tests, Middle Aged, MESH: Predictive Value of Tests, Test (assessment), MESH : Neuropsychological Tests, MESH: Point-of-Care Systems, Stroke, Treatment Outcome, [INFO.INFO-TI]Computer Science [cs]/Image Processing [eess.IV], Female, medicine.symptom, Psychology, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, MESH : Male, Clinical Neurology, Outcomes, MESH : Treatment Outcome, Rating scale, Language outcome, Physical medicine and rehabilitation, Predictive Value of Tests, MESH : Language, medicine, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, Speech, Dysarthria, [SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Reproducibility of Results, [INFO.INFO-CV]Computer Science [cs]/Computer Vision and Pattern Recognition [cs.CV], MESH: Male, [SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging, ROC Curve, MESH : ROC Curve, MESH : Speech, Follow-Up Studies
Abstract

The Aphasia Rapid Test (ART) is a 26-point scale developed as a bedside assessment to rate aphasia severity in acute stroke patients in 21 for poor outcome, with more than 90 % sensitivity and 80 % specificity. The ART is a simple, rapid and reproducible language task, useful in monitoring early aphasic changes in acute stroke patients and highly predictive of the 3-month verbal communication outcome. It should be easy to adapt to other languages. Electronic supplementary material The online version of this article (doi:10.1007/s00415-013-6943-x) contains supplementary material, which is available to authorized users.

Published
2013

5. Sensitivity to change of two depression rating scales for stroke patients

Author

Charles Benaim, Pierre Decavel, Jacques Pélissier, Marc Bentabet, Jérôme Froger, Dominic Pérennou, Motricité - Plasticité, Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Unité de Rééducation Neurologique, Centre Hélio-Marin CHU Nîmes, Euromov ( EuroMov ), Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Montpellier ( UM ), SPM, Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications [Grenoble] ( TIMC-IMAG ), Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut polytechnique de Grenoble - Grenoble Institute of Technology ( Grenoble INP ) -IMAG-Centre National de la Recherche Scientifique ( CNRS ) -Université Grenoble Alpes ( UGA ) -Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut polytechnique de Grenoble - Grenoble Institute of Technology ( Grenoble INP ) -IMAG-Centre National de la Recherche Scientifique ( CNRS ) -Université Grenoble Alpes ( UGA ), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM), Euromov (EuroMov), Université de Montpellier (UM), Santé, Plasticité, Motricité (TIMC-IMAG-SPM), Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG), and VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)

Subjects
Male, MESH: Psychiatric Status Rating Scales, MESH : Stroke, Stroke patient, medicine.medical_treatment, MESH: Depressive Disorder, MESH : Aged, MESH : Analysis of Variance, Severity of Illness Index, Mood scale, [ SDV.NEU.SC ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, 0302 clinical medicine, MESH : Female, 030212 general & internal medicine, Depression (differential diagnoses), MESH: Aged, MESH : Aphasia, Rehabilitation, MESH: Middle Aged, Stroke Rehabilitation, [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, Middle Aged, MESH : Adult, Stroke, Female, MESH : Severity of Illness Index, Patient status, MESH : Sensitivity and Specificity, MESH : Psychiatric Status Rating Scales, Psychology, Clinical psychology, Adult, medicine.medical_specialty, MESH : Male, Physical Therapy, Sports Therapy and Rehabilitation, Sensitivity and Specificity, MESH: Stroke, 03 medical and health sciences, Rating scale, MESH: Severity of Illness Index, MESH: Analysis of Variance, Aphasia, medicine, Humans, MESH : Middle Aged, Sensitivity to change, Aged, MESH: Aphasia, Psychiatric Status Rating Scales, Analysis of Variance, Depressive Disorder, MESH: Humans, MESH : Humans, MESH: Adult, MESH: Sensitivity and Specificity, MESH: Male, MESH : Depressive Disorder, Physical therapy, MESH: Female, 030217 neurology & neurosurgery
Abstract

Objective: To assess the sensitivity to change of two depression scales for stroke patients: the Aphasic Depression Rating Scale (ADRS), which is a 9-item external assessment, and the Visual Analog Mood Scale (VAMS), which is a visual self-assessment scale. Patients: Forty-nine stroke patients admitted to two rehabilitation units. Methods: Symptoms of depression were assessed twice at a one-month interval (D0—D30) using the ADRS, the VAMS, and by a trained psychologist (PSY). Sensitivity to change was assessed by effect size and standardized response mean. A one-way ANOVA on ranks was performed to determine if the scales distinguished between deteriorated, stable and improved patient status. Spearman’s correlation coefficient (r) was used to assess the relationship between changes in PSY and changes in the ADRS and the VAMS between D0 and D30. Results: Mean depression scores at D0 and D30 were 2.6 ± 1.8 and 2.4 ± 1.7 (ADRS/10), 3.1 ± 2.9 and 3.0 ± 3.2 (VAMS/10), 2.9 ± 2.3 and 2.4 ± 2.4 (PSY/10). Percentages of deteriorated, stable and improved patient status were 22%, 45% and 33% (ADRS); 41%, 22% and 37% (VAMS); and 20%, 41% and 39% (PSY). Changes in PSY correlated with the ADRS (r = 0.72, P —6) and the VAMS (r = 0.41, P— 2). The ADRS was better than the VAMS in terms of effect size, standardized response mean and ability to discriminate between deteriorated, stable and improved patient status. This result was partly due to the difficulty encountered by nine (19%) patients in understanding directions to complete the VAMS. Conclusions: The ADRS is more sensitive than the VAMS for detecting changes in post-stroke depression. The VAMS is less appropriate in very cognitively impaired stroke patients.

Published
2010
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6. Middle short gyrus of the insula implicated in speech production: intracerebral electric stimulation of patients with epilepsy

Author

Lorella Minotti, Philippe Kahane, Dominique Hoffmann, Afif Afif, Service de neurochirurgie, Hospices Civils de Lyon (HCL)-Hopital Neurologique, Intégration centrale de la douleur chez l'homme, Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM), ANTE-INSERM U836, équipe 9, Dynamique des réseaux synchrones épileptiques, Dynamique des Reseaux Neuronaux, Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Neurochirurgie, CHU Grenoble-Hôpital Michallon, and Deransart, Colin

Subjects
Male, Speech production, Electrical stimulation, Drug Resistance, Insula, Stereotaxic Techniques, Epilepsy, 0302 clinical medicine, Gyrus, MESH: Child, Child, MESH: Brain Mapping, Cerebral Cortex, 0303 health sciences, Brain Mapping, MESH: Middle Aged, MESH: Speech, MESH: Electric Stimulation, Electroencephalography, Middle Aged, Electrodes, Implanted, medicine.anatomical_structure, Neurology, MESH: Drug Resistance, Anticonvulsants, Female, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Psychology, MESH: Preoperative Care, Adolescent, Voice Quality, SEEG, MESH: Stereotaxic Techniques, Insular cortex, Stereoelectroencephalography, 03 medical and health sciences, MESH: Anticonvulsants, MESH: Voice Quality, Preoperative Care, MESH: Electroencephalography, medicine, Aphasia, Humans, Speech, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], 030304 developmental biology, MESH: Aphasia, MESH: Adolescent, MESH: Humans, medicine.disease, Electric Stimulation, MESH: Male, MESH: Cerebral Cortex, Functional imaging, MESH: Epilepsies, Partial, nervous system, Stereotaxic technique, MESH: Electrodes, Implanted, Neurology (clinical), Epilepsies, Partial, Neuroscience, MESH: Female, 030217 neurology & neurosurgery
Abstract

Summary Purpose: Different lines of evidence have suggested an involvement of the insular cortex in speech production. These have included results from lesion studies, functional imaging techniques, and electrical stimulation of the human insular cortex during invasive evaluation of epileptic patients. Methods: We evaluated 25 patients who had drug refractory focal epilepsy with at least one electrode stereotactically implanted in the insular cortex. Results: Eight responses to insular cortex electrical stimulation were reported by five patients as speech arrest (five responses) and a lowering of voice intensity (three responses). Conclusions: Data from this study implicate the middle short gyrus of the insula in the production of speech and show the importance of intrainsular electrode implantation during invasive pre-resection evaluation by stereo-electroencephalography (SEEG) when speech arrest occurs early in seizure semiology.

Published
2010
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7. [Fluctuating aphasia and epileptic crisis in a 60 year-old man: contrast microscopy of leptomeninges and white matter]

Author

S, Hamelin, Deransart, Colin, Unité ' Epilepsie et Malaises Neurologiques ', and CHU Grenoble-Département de Neurologie

Subjects
Male, MESH: Humans, MESH: Middle Aged, Brain, Contrast Media, Middle Aged, Magnetic Resonance Imaging, MESH: Male, MESH: Magnetic Resonance Imaging, MESH: Brain, MESH: Contrast Media, Aphasia, Humans, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], MESH: Aphasia
Abstract

International audience; pas de résumé

Published
2009

8. [Functional neuroimaging and the treatment of aphasia: speech therapy and repetitive transcranial magnetic stimulation]

Author

X, de Boissezon, G, Raboyeau, M, Simonetta-Moreau, M, Puel, J F, Démonet, D, Cardebat, Service de Médecine Physique et Réadaptation, CHU Toulouse [Toulouse]-Hôpital de Rangueil, CHU Toulouse [Toulouse], Imagerie cérébrale et handicaps neurologiques (ICHN), Institut des sciences du cerveau de Toulouse. (ISCT), Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Neurologie générale et maladies inflammatoires du système nerveux [Toulouse], Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Hôpital Purpan [Toulouse], De Boissezon, Xavier, Service Médecine physique et de réadaptation [CHU Toulouse], Pôle Neurosciences [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Pôle Santé publique et médecine publique [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Cerebral Cortex, MESH: Humans, MESH: Speech Therapy, Speech Therapy, Magnetic Resonance Imaging, Transcranial Magnetic Stimulation, MESH: Image Processing, Computer-Assisted, Functional Laterality, MESH: Cerebral Cortex, MESH: Magnetic Resonance Imaging, MESH: Transcranial Magnetic Stimulation, MESH: Language, Aphasia, Image Processing, Computer-Assisted, Humans, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], MESH: Functional Laterality, Language, MESH: Aphasia
Abstract

International audience; Functional imaging has provided new evidence of the neurobiological impact of the treatment of aphasia, including speech therapy, through the alteration of the activated language neural network. In such a way, speech therapy has proved its impact. The role of each hemisphere is still very unclear. Some of the authors link the left-lateralisation of activations to the therapeutic improvement of language and the right-activated network to a maladaptative strategy, whereas others consider the latter as a useful compensatory network for speech disorders. Repetitive trans-cranial magnetic stimulation (rTMS), first used to determine cortical activity, is now used to directly interfere with cerebral activity. In the years to come, rTMS should be developed as an adjuvant therapy for aphasia.

Published
2008
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