1. Five‐Year Lower Extremity Function is Associated with White Matter Abnormality in Older Adults
- Author
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Bruno Vellas, Jean-François Mangin, Philipe de Souto Barreto, Kelly Virecoulon Giudici, Audrey Gabelle, Lisa Perus, Yves Rolland, Lingxiao He, Institut du Vieillissement, Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Université de Toulouse (UT), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC), Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Université de Montpellier (UM), CEA- Saclay (CEA), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)
- Subjects
Male ,Internal capsule ,[SDV]Life Sciences [q-bio] ,MESH: Lower Extremity ,Corpus callosum ,Activities of Daily Living ,Cingulum (brain) ,Correlation of Data ,older adults ,MESH: Aged ,MESH: Correlation of Data ,Physical Functional Performance ,White Matter ,Diffusion Tensor Imaging ,medicine.anatomical_structure ,Lower Extremity ,Disease Progression ,symbols ,MESH: Disease Progression ,Female ,MESH: Diffusion Tensor Imaging ,medicine.medical_specialty ,MESH: Physical Functional Performance ,Uncinate fasciculus ,lower extremity function ,MESH: Walking Speed ,White matter ,symbols.namesake ,Physical medicine and rehabilitation ,MESH: Mobility Limitation ,Connectome ,medicine ,Humans ,Mobility Limitation ,MESH: Connectome ,Aged ,MESH: Humans ,business.industry ,MESH: Activities of Daily Living ,MESH: Male ,Walking Speed ,Bonferroni correction ,MESH: Nerve Net ,MESH: White Matter ,Cerebellar peduncle ,Nerve Net ,Geriatrics and Gerontology ,business ,MESH: Female ,Diffusion MRI - Abstract
International audience; Objective: To explore associations between changes of lower extremity function (LEF) parameters over a 5-year period and diffusion tensor imaging (DTI) parameters of white matter tracts among community-dwelling older adults.Design: A secondary analysis on image and physical function data collected from the Multidomain Alzheimer's Preventive Trial (MAPT).Participants: 208 older adults (aged 75 ± 4 years, with spontaneous memory complaint or limited instrumental daily living activity or slow gait speed, 60% female) of the MAPT-magnetic resonance imaging (MRI) ancillary study. The time interval between a participant's enrolment and MRI scan was on average 110 ± 97 days.Measurements: Forty-eight white matter tracts (WMTs) were measured. LEF parameters (measured after the MRI scan) were assessed as the short physical performance battery (SPPB) score, gait speed, and chair stands time over a 5-year period. Mixed-effects models were performed to explore the associations between baseline DTI values and the progression of LEF parameters. Bonferroni correction was applied for multiple comparison correction.Results: The progression of LEF was associated with 35 baseline DTI parameters from 24 WMTs. Higher baseline DTI parameter values were related to more decreases in SPPB score and gait speed, and greater increases in chair stands time. Bilateral uncinate fasciculus was associated with all LEF parameters. Other WMTs in cingulum, cerebral and cerebellar peduncle, internal capsule, and corpus callosum also showed close connections with LEF changes.Conclusions: Our findings show that DTI parameters of some WMTs are associated with the 5-year decline in LEF, suggesting that alterations in WMT integrity (evaluated by DTI parameters) might be used to explore potential causes of impaired mobility in older adults when no clear explanations can be found.
- Published
- 2021