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327 results on '"MELUCCI, DORA"'

12. Extraction Improvement and Chemometric Study

Author

Ferri, Maura, Lima, Vasco, Zappi, Alessandro, Fernando, Ana Luísa, Melucci, Dora, Tassoni, Annalisa, DQ - Departamento de Química, and MEtRICS - Centro de Engenharia Mecânica e Sustentabilidade de Recursos

Subjects
Merlot, grape pomace, phenolic compounds, Plant Science, chemometrics, Microbiology, Health Professions (miscellaneous), Garganega, Health(social science), RP-HPLC-DAD, enzymatic extraction, organic solvents, by-products, Food Science
Abstract

Funding Information: This work was supported by the NoAW project (‘‘Innovative approaches to turn agricultural waste into ecological and economic assets”), founded by the European Union Horizon 2020 research and innovation program under the grant agreement No 688338. This research was carried out within the Agritech National Research Center and received funding from the European Union Next-GenerationEU (PIANO NAZIONALE DI RIPRESA E RESILIENZA (PNRR)–MISSIONE 4 COMPONENTE 2, INVESTIMENTO 1.4–D.D. 1032 17/06/2022, CN00000022), Italy. This study was also funded by national funding by FCT, Foundation for Science and Technology, MCTES, and by ESF (European Social Fund) through NORTE 2020 (Programa Operacional Região Norte), Portugal, through the individual PhD research grant (SFRH/BD/146080/2019) of V.L. This work was also supported by the MEtRICs unit which is funded by national funds from FCT/MCTES (UIDB/04077/2020 and UIDP/04077/2020) and by the Associate Laboratory for Green Chemistry–LAQV which is financed by national funds from FCT/MCTES (UIDB/50006/2020 and UIDP/50006/2020). Publisher Copyright: © 2023 by the authors. In the last 20 years, an increased interest has been shown in the application of different types and combinations of enzymes to obtain phenolic extracts from grape pomace in order to maximize its valorization. Within this framework, the present study aims at improving the recovery of phenolic compounds from Merlot and Garganega pomace and at contributing to the scientific background of enzyme-assisted extraction. Five commercial cellulolytic enzymes were tested in different conditions. Phenolic compound extraction yields were analyzed via a Design of Experiments (DoE) methodology and a second extraction step with acetone was sequentially added. According to DoE, 2% w/w enzyme/substrate ratio was more effective than 1%, allowing a higher total phenol recovery, while the effect of incubation time (2 or 4 h) variation was more enzyme-dependent. Extracts were characterized via spectrophotometric and HPLC-DAD analyses. The results proved that enzymatic and acetone Merlot and Garganega pomace extracts were complex mixtures of compounds. The use of different cellulolytic enzymes led to different extract compositions, as demonstrated using PCA models. The enzyme effects were observed both in water enzymatic and in the subsequent acetone extracts, probably due to their specific grape cell wall degradation and leading to the recovery of different molecule arrays. publishersversion published

Published
2023

17. Characteristics, comorbidities and laboratory measures associated with disease severity and poor prognosis in young and elderly patients with COVID-19 admitted to medical wards in Emilia-Romagna region, Italy: a multicentre retrospective study.

Author

Fiorino, Sirio, Carusi, Andrea, Zappi, Alessandro, Tateo, Fabio, Peruzzo, Luca, Zanardi, Melissa, Savelli, Francesco, Di Marzio, Giulia, Cesaretti, Silvia, Dazzani, Francesca, Francesconi, Raffaella, Leandri, Paolo, Tortorici, Gianfranco, Vicari, Susanna, Melucci, Dora, and Lari, Federico

Abstract

Background and Objectives. A relatively small number of studies have investigated the characteristics, comorbidities and laboratory measures associated with prognosis in patients with COVID-19, admitted to Internal Medicine Units (IMU) in Italy. Therefore, we performed a retrospective multicentre study to identify baseline features, predisposing to severe disease and poor outcomes, in adult individuals with SARS-CoV2 infection, hospitalized in 5 IMUs in the Emilia-Romagna region (Italy). Materials and Methods. We included 129 consecutive patients (male 75, median age 68 years) from 1st March 2020 to 31st October 2021. Patients’ baseline characteristics, comorbidities, laboratory measures, and outcomes were collected. Results. At admission, the factors significantly associated with a higher risk of in-hospital mortality included: age (median 68 vs. 83 years in survived vs. dead patients, P=0.000), diabetes [Odds Ratio (OR) 4.00, P=0.016], chronic obstructive pulmonary disease (OR 4.60, P=0.022), cancer (OR 5.81, P=0.021), acute- (OR 9.88, P=0.000) and chronicrenal failure (OR 6.76, P=0.004). During the study period, 16 individuals died (12.4%), all over 70 years old. In deceased vs. non-deceased patients were detected: i) more elevated white blood cells and neutrophils-counts and lower lymphocytes count; ii) higher levels of total/direct bilirubin, creatinine, C-reactive-protein, lactate-dehydrogenase, ferritin, but only a slight Interleukin-6 increase; iii) a trend of lower vitamin D values. Conclusions. We proposed a new I index, a modified form of the Age-Adjusted Charlson Comorbidity Index, by considering pO2/FiO2 ratio, to better characterize the severity of COVID-19. Furthermore, we critically discuss our results with the current assumption which considers COVID-19 as a pathological condition associated with cytokine storm. [ABSTRACT FROM AUTHOR]

Published
2023
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30. Multianalyte voltammetric determination of traffic-linked metals in marine organisms employed as pollution bio-monitors.

Author

Locatelli, Clinio, Melucci, Dora, De Laurentiis, Francesco, Zappi, Alessandro, and Casolari, Sonia

Subjects
*PLATINUM, *MARINE organisms, *PLATINUM group, *METALS, *STANDARD hydrogen electrode, *SODIUM dichromate, *MICROBIOLOGICAL aerosols, *RHODIUM compounds
Abstract

A new procedure is proposed for the voltammetric determination of ultra-trace cadmium(II), copper(II), lead(II), platinum(II), palladium(II), rhodium(III) and zinc(II) by a single run of square wave adsorptive catalytic stripping voltammetry. The voltammetric cell was based on a typical three-electrodes set-up: working electrode (stationary hanging mercury drop), reference electrode (Ag|AgCl|KClsat) and auxiliary electrode (platinum). The supporting electrolyte contained the formazone complex together with dimethylglyoxime and the disodium salt of ethylenediaminetetraacetic acid. Validation of the analytical procedure was obtained by the analysis of standard reference materials (Mussel Tissue BCR-CRM 278, Oyster Tissue NIST-SRM 1566a). Comparison with spectroscopic measurements was performed. Good accuracy was achieved. The analytical procedure was finally applied to mussels and clams sampled on the mouth of Po river, employed as bio-monitors. [ABSTRACT FROM AUTHOR]

Published
2022
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31. L’uso dei risultati del Questionario di Percezione delle Competenze Strategiche (QPCS) nell’ambito di un percorso di orientamento in ingresso con studenti universitari. L’esperienza del Piano Lauree Scientifiche (PLS) – Chimica dell’Università di Bologna

Author

Boga, Carla, Melucci , Dora, Strocchi , Elena, Marcuccio, Massimo, and Zappoli , Sergio

Abstract

Uso del QPCS con matricole universitarie (PLS–Chimica Unibo) dall’a.a. 2018-19, con ipotesi di partenza: lo sviluppo dell’autodirezione nell’apprendimento favorisce la continuità negli studi. Il percorso è in tre fasi: a) somministrazione del QPCS a matricole chimiche (N=436); b) restituzione in presenza dei risultati; c) tutorato a 44 studenti. Riflessioni: modalità di restituzione, uso dei risultati QPCS, reazioni degli studenti. Obiettivo: costruire un quadro concettuale per futura ricerca., Dirigere se stessi nello studio e nel lavoro. Competenzestrategiche.it: strumenti e applicazioni

Published
2020
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47. Novel MIPs-Parabens based SPE Stationary Phases Characterization and Application

Author

Tartaglia, Angela, primary, Kabir, Abuzar, additional, Ulusoy, Songul, additional, Ulusoy, Halil Ibrahim, additional, Merone, Giuseppe Maria, additional, Savini, Fabio, additional, D’Ovidio, Cristian, additional, de Grazia, Ugo, additional, Gabrielli, Serena, additional, Maroni, Fabio, additional, Bruni, Pantaleone, additional, Croce, Fausto, additional, Melucci, Dora, additional, Furton, Kenneth G., additional, and Locatelli, Marcello, additional

Published
2019
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