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• AI enhances biomechanical model precision, improving prediction accuracy. • AI reveals novel mechanical signaling, advancing cellular response understanding. • AI boosts early disease detection using advanced mechanodiagnosis methods. • AI optimizes mechanotherapy with personalized strategies based on real-time data. • Challenges remain in data quality and ethical use of AI in clinical settings. Mechanomedicine is an interdisciplinary field that combines different areas including biomechanics, mechanobiology, and clinical applications like mechanodiagnosis and mechanotherapy. The emergence of artificial intelligence (AI) has revolutionized mechanomedicine, providing advanced tools to analyze the complex interactions between mechanics and biology. This review explores how AI impacts mechanomedicine across four key aspects, i.e. , biomechanics, mechanobiology, mechanodiagnosis, and mechanotherapy. AI improves the accuracy of biomechanical characterizations and models, deepens the understanding of cellular mechanotransduction pathways, and enables early disease detection through mechanodiagnosis. In addition, AI optimizes mechanotherapy that targets biomechanical features and mechanobiological markers by personalizing treatment strategies based on real-time patient data. Even with these advancements, challenges still exist, particularly in data quality and the ethical integration into AI in clinical practice. The integration of AI with mechanomedicine offers transformative potential, enabling more accurate diagnostics and personalized treatments, and discovering novel mechanobiological pathways. [ABSTRACT FROM AUTHOR]

Neuromuscular deficits affecting functional ability can occur in patients with Achilles tendinopathy during difficult balance activities. This study aimed to assess postural control in patients with Achilles tendinopathy after shockwave and sonotherapy, using advanced analytical methods, including rambling-trembling signal decomposition and sample entropy. What are the differences in postural control between patients with Achilles tendinopathy after shockwave therapy, ultrasound therapy, and placebo ultrasound? Thirty-nine patients were included in the study, and randomly assigned to 3 groups, i.e., shockwave therapy, ultrasound therapy and placebo ultrasound. Postural sway was assessed during quiet standing with eyes open and closed, with two force platforms, one for the affected and the other for the non-affected limb, at baseline and at weeks 1 and 6 after treatment. Rambling-trembling trajectories and sample entropy were calculated for the antero-posterior and medio-lateral directions. The parameters of trembling trajectory in both directions were significantly smaller for the affected compared to non-affected limb. The ultrasound group had significantly larger rambling-trembling trajectories in the antero-posterior and medio-lateral sway directions than the shockwave therapy group. Also, all patients had more difficulty controlling their postural sway while standing with eyes closed compared to eyes open. Sample entropy was not significantly affected by the therapy type, timepoint and limb condition. As opposed to sample entropy, rambling-trembling decomposition can complement or replace traditional linear measures of COP time series in functional assessment of the Achilles tendon. • Patients with Achilles tendinopathy have altered postural control. • Trembling trajectory is smaller for the affected compared to non-affected limb. • Rambling-trembling method may contribute to the assessment of the Achilles tendon. [ABSTRACT FROM AUTHOR]

Physical therapists, equipped with unique diagnostic and treatment capabilities, play a pivotal role in advancing regenerative medicine. The present review explores the integration of mechanotherapy and mechanical techniques in physiotherapy, shedding light on the burgeoning field of mechanobiology and its implications for rehabilitative therapies. A comprehensive literature search was conducted using various databases, including Google Scholar, PubMed, Scopus, Web of Science, and CINAHL. Initially, a total of 217 articles, including research papers, reviews, and systematic reviews, were identified. After thorough evaluation, 26 articles were deemed relevant to the present study. The authors analysed these selected articles to explore the utilisation of mechanotherapy, mechanotransduction, and the integration of mechanobiological principles into physiotherapy practice. Physiotherapists employ mechanotherapy and mechanical techniques, such as manual mobilisation and exercise interventions, to treat diseases and injuries and restore function. Mechanobiology studies the essential functions that these physical variables perform through mechanotransduction, while Mechanotherapies emphasise natural mechano-adaptation to promote healing. They are active mechano-interventions that transform possible damaging mechanical effects into therapeutic benefits. Therefore, interventions should be planned accordingly. The growing field of mechanobiology and regenerative medicine is opening new avenues for rehabilitative therapies. Applying mechanobiology principles to various body systems linked to physical therapy interventions provides scope for future research.

INTRODUCTION. The development of rehabilitation methods for patients with sarcopenia, a generalized age-associated loss of skeletal muscle mass and strength, is important, since sarcopenia leads to pronounced weakness, functional and motor disorders and an increased risk of death in the elderly. AIM. To analyze the prevalence, features of pathogenesis, diagnosis of secondary sarcopenia, including against the background of motor disorders due to stroke, as well as methods of treatment and medical rehabilitation of such patients. MAIN CONTENT. Among the secondary forms, sarcopenia is of the greatest clinical importance against the background of the consequences of acute cerebrovascular accident (ACA), due to muscular atrophy associated with paralysis and immobility, spasticity, inflammation and denervation of muscles, malnutrition and intestinal absorption of protein and vitamin D. Recent studies show that the prevalence of sarcopenia in stroke patients in emergency hospitals is 8.5–33.8 %, according to other data — more than 42 %. Muscle weakness after a stroke contributes to a decrease in physical functions and the development of disability, and sarcopenia leads to adverse outcomes 90 days after a stroke. According to the meta-analysis, which included 7 cohort studies with a total sample of 1,774 patients who underwent ACA, 27.1 % of them had sarcopenia. Moreover, the presence of sarcopenia negatively affected the clinical and functional outcomes of ACA, as well as the results of medical rehabilitation (odds ratio: 2.42, 95 % confidence interval: 1.76–3.33, p 0.001). CONCLUSION. Despite the prevalence and relevance of this pathology, rehabilitation programs for patients with sarcopenia against the background of the consequences of ACA have not been developed. Isolated foreign publications demonstrate the effectiveness of certain methods of physical therapy and electrical stimulation, but the evidence base for their effectiveness is low.

Mechanotherapy has emerged as a promising treatment for tissue injury. However, existing robots for mechanotherapy are often designed on intuition, lack remote and wireless control, and have limited motion modes. Herein, through topology optimization and hybrid fabrication, wireless magneto‐active soft robots are created that can achieve various modes of programmatic deformations under remote magnetic actuation and apply mechanical forces to tissues in a precise and predictable manner. These soft robots can quickly and wirelessly deform under magnetic actuation and are able to deliver compressing, stretching, shearing, and multimodal forces to the surrounding tissues. The design framework considers the hierarchical tissue‐robot interaction and, therefore, can design customized soft robots for different types of tissues with varied mechanical properties. It is shown that these customized robots with different programmable motions can induce precise deformations of porcine muscle, liver, and heart tissues with excellent durability. The soft robots, the underlying design principles, and the fabrication approach provide a new avenue for developing next‐generation mechanotherapy. [ABSTRACT FROM AUTHOR]

Cerebrovascular accident (CVA) is a disease that affects motor functionality and quality of life in patients. This article explores the efficacy and safety of physical therapy approaches through the practice of resistance exercises with mechanotherapeutic equipment in post-stroke rehabilitation, analyzing the current literature to provide a comprehensive and grounded view on the subject. [ABSTRACT FROM AUTHOR]

Aim: To evaluate and Compare Skeletal, Dentoalveolar and Soft tissue effects of the Forsus FRD and AdvanSync2 Fixed Functional Appliances for correction of Angle's Class II Division 1 Malocclusion. Material and Methods: Twenty Participants were selected and randomly divided into Group 1 (Forsus FRD) and Group 2 (AdvanSync2). In Group I: After alignment and levelling, with tightly cinched 0.019*0.025 Stainless Steel Arch Wires in both upper and lower arches along with Trans-Palatal Arch in Maxilla for additional Anchorage, Forsus FRD Fixed Functional Appliance were inserted. In Group II: Pre-Adjusted Edgewise fixed Mechanotherapy with 0.022 MBT bracket system were bonded in both the upper and the lower arches. AdvanSync2 Appliance was installed simultaneously along with initiation of Aligning and levelling on the same appointment. Lateral Cephalograms were taken at time intervals T0 (Before Starting Fixed-Functional appliance therapy) & T1 (After completion of Fixed-Functional appliance therapy) were analyzed with selected skeletal, dental and soft-tissue parameters on Dolphin Imaging Software (Version 11.5). Results: Comparison between two groups suggest that the Forsus FRD group and AdvanSync2 Group showed similar pre and post treatment Skeletal, Dentoalveolar and soft tissue Effects except AdvanSync2 group showed significantly higher Angle SNA-T1-T0 difference (p < 0.001) and Advansync2 group has a significantly greater angle FMA-T1 and FMA-T1-T0 (p < 0.001) difference compared to the Forsus FRD group. U6-NF Angular-T1 and U6-NF Angular-T1-T0 difference is significantly higher (p < 0.001) in Forsus FRD group and that L6- MP Angular-T1 and L6- MP Angular-T1-T0 (p < 0.001) difference is significantly higher in AdvanSync2 group. Conclusion: Both Forsus FRD and Advansync2 Fixed Functional Appliance aid in the treatment of Class II malocclusion in post-pubertal patients with maximum Dentoalveolar alterations, minimum Skeletal alterations and mild Soft Tissue alteration. AdavnSync2 Fixed Functional Appliance reported headgear effect on maxilla unlike Forsus FRD. Compared to Forsus FRD, AdavnSync2 Fixed Functional Appliance reported significant increase in facial divergence. AdavnSync2 Fixed Functional Appliance reported mesial tipping of mandibular first permanent molars unlike Forsus FRD. Compared to AdavnSync2, Forsus FRD appliance reported significant distal tipping of maxillary first molars. [ABSTRACT FROM AUTHOR]

Purpose: To investigate the influence of therapeutic exercises on functional recovery after supratentorial unilateral ischemic stroke (SUIS). Contingent and methods: The study was conducted in 78 patients with supratentorial unilateral stroke in the chronic period (SUISChP) - (67 patients in the experimental group (EG) - 36 males and 31 women with a pathology duration of 6.9±3.0 months and 11 patients in the control group (CG) - 9 men and 2 women with pathology duration 7.3±1.5 months). Patients from the EG were treated with a specialized 10-day kinesitherapy (KT), which was later performed as an adapted home exercise program for a period of 1 month. A modified Chedoke-McMaster scale was used to determine the gravity of the phase that the 4th and 5th stage patients had a moderate degree of involvement, and the 6th and 7th stages had a slight degree of involvement. On this basis, the patients were divided into two subgroups (moderate and mild). Results: Compared to baseline data in the experimental group, there was a significant improvement in upper and lower extremity abilities as shown by the Chedoke-McMaster test. The results of monitoring the muscle tone of upper and lower limbs, according to the Ashworth scale before and after kinesitherapy in EG, are similar. An improvement between mild and absent spasticity was noted, and the results are maximal at 1 month of treatment (p<0.001). Conclusion: The lasting positive effect in EG may be related to different mechanisms in which the applied goal-directed movements affect the functional capabilities of patients with SUISChP. [ABSTRACT FROM AUTHOR]

The ultrasound, as one of the non-invasive intervention or regulation measures in mechanotherapy, has attracted much attention. The methods, effects and action mechanisms of 4 types of ultrasounds for tissues/ cells, namely, the high-frequency high-intensity ultrasound, the low-frequency high-intensity ultrasound, the low-frequency low-intensity ultrasound and the high-frequency low-intensity ultrasound were reviewed, and the emerging ultrasound therapeutic instrumentations were introduced. Then the future development trends of ultrasonic mechanotherapeutics were discussed. This review helps to promote the technical progress and clinical application of ultrasound mechanotherapy in tumor treatment, neurologic diseases (such as Alzheimer's disease and Parkinson's disease) treatment and so on. [ABSTRACT FROM AUTHOR]

Stage IV periodontitis is characterized, apart from high severity/complexity (attachment loss, radiographic bone loss, and deep probing depths), from loss of multiple teeth and/or alterations of the masticatory function. Periodontitis stage IV patients are often characterized by pathologic tooth migration, drifting, flaring, posterior bite collapse, and secondary occlusal trauma. These act as complexity factors not only for the management of periodontitis, but also for the prognosis of the whole dentition, and the majority of these patients present secondary malocclusions that require interdisciplinary treatment with orthodontics. However, the management of stage IV patients is complex and requires coordination between the periodontal and orthodontic specialist, while orthodontic treatment needs to be appropriately adjusted to the specificities of adult periodontally-stable patients with severely reduced periodontium. The aim of the paper is to discuss the orthodontic management of these patients, including conditions that need to be met for orthodontic treatment to start, treatment-related considerations pertaining to appliance choice and mechanotherapy, as well as post-treatment maintenance protocols to ensure long-term stability of the treatment results. Finally, an updated systematic review with meta-analysis is presented that summarizes clinical evidence on the effect of combined periodontal-orthodontic treatment for stage IV periodontitis patients with pathological tooth migration. [ABSTRACT FROM AUTHOR]

Orthodontic retention has evolved into an essential element of orthodontic treatment, applicable regardless of a patient's age, specific malocclusion, or the type of mechanotherapy employed. It is common practice in many regions to utilize fixed retention in a majority of patients. Existing research suggests that the presence of fixed retainers has a relatively minimal impact on periodontal tissues. However, given the often prolonged, and sometimes lifelong, retention periods, it is essential to acknowledge specific limitations within the scientific literature. These include the relatively short durations of observation in most randomized clinical studies, the potential influence of the Hawthorne effect, selection bias (such as the inclusion of patients with exemplary hygiene), and the risk of retainer activation. Therefore, it is advisable to exercise caution when assuming that fixed retainers are entirely free of risks to periodontal health. [ABSTRACT FROM AUTHOR]

The "Unhappy Triad" or "O'Donoghue's Triad" is one of the most severe multiligamentous sports injuries that involves a tear of the ACL, MCL and medial meniscus of the knee. Recovery after surgical treatment is between 6 and 12 months, and many athletes after this injury do not return to their sports activities. Purpose: to follow the functional state of the knee complex in patients after surgical treatment of the "Unhappy Triad", before and after 10 days of kinesitherapy in the moderately protective period. Methodology: 70 patients after surgical treatment of the "Unhappy Triad" were studied, 32 were assigned to a control group (CG) and 38 to an experimental group (EG). In all patients, the treatment of the MCL rupture was conservative (30 days of knee immobilization) with subsequent surgery that included partial meniscectomy and ACL reconstruction using the BPTB method. A traditional model of kinesitherapy was applied in the CG, and in the EG the following were applied: instrumentally assisted soft tissue mobilization - Ergon® IASTM Technique, kinesio tape, post-isometric relaxation, stretching, proprioceptive training, locomotor training, analytical exercises and aquatherapy for 10 days. To monitor changes in the functional state of the knee, a functional scale for complex assessment according to D. Seligson was applied, before and after 10 days of kinesitherapy. Results: the initial average cumulative assessment of the functional state of the damaged knee in CG before kinesitherapy was 4.688, and in EG it was similar – 5.105. The values indicate a severe functional state on the first day of the study. After 10 days of kinesitherapy there was a significant improvement in results in both groups. In absolute values, the functional state of the knee in CG increased by 5.37, and in relative values by 114.67%, in EG it increased by 7.9 or the improvement was by 155.66%. As a result, the final mean cumulative score of patients in the control group was 10.06 and in the experimental group it was 13.05. The testing of the hypotheses for the significance of the differences of the variable in the two groups shows that P>0.05 on the first day of the study, from which it follows that the groups are the same in terms of the studied indicator, and on the tenth day P<0.05, which proves the existence of a statistically significant difference in the average values of the indicator in favor of EG. Conclusions: The applied model of kinesitherapy in the experimental group is more effective and contributes to a more significant complex restoration of the functional state of the knee joint of the patients, compared to the traditional model of kinesitherapy in the control group. [ABSTRACT FROM AUTHOR]

Peripheral nerve injuries lead to significant morbidity and adversely affect quality of life. The peripheral nervous system harbors the unique trait of autonomous regeneration; however, achieving successful regeneration remains uncertain. Research continues to augment and expedite successful peripheral nerve recovery, offering promising strategies for promoting peripheral nerve regeneration (PNR). These include leveraging extracellular vesicle (EV) communication and harnessing cellular activation through electrical and mechanical stimulation. Small extracellular vesicles (sEVs), 30-150 nm in diameter, play a pivotal role in regulating intercellular communication within the regenerative cascade, specifically among nerve cells, Schwann cells, macrophages, and fibroblasts. Furthermore, the utilization of exogenous stimuli, including electrical stimulation (ES), ultrasound stimulation (US), and extracorporeal shock wave therapy (ESWT), offers remarkable advantages in accelerating and augmenting PNR. Moreover, the application of mechanical and electrical stimuli can potentially affect the biogenesis and secretion of sEVs, consequently leading to potential improvements in PNR. In this review article, we comprehensively delve into the intricacies of cell-to-cell communication facilitated by sEVs and the key regulatory signaling pathways governing PNR. Additionally, we investigated the broad-ranging impacts of ES, US, and ESWT on PNR. [ABSTRACT FROM AUTHOR]

Abstract Mechanotherapy has emerged as a promising treatment for tissue injury. However, existing robots for mechanotherapy are often designed on intuition, lack remote and wireless control, and have limited motion modes. Herein, through topology optimization and hybrid fabrication, wireless magneto‐active soft robots are created that can achieve various modes of programmatic deformations under remote magnetic actuation and apply mechanical forces to tissues in a precise and predictable manner. These soft robots can quickly and wirelessly deform under magnetic actuation and are able to deliver compressing, stretching, shearing, and multimodal forces to the surrounding tissues. The design framework considers the hierarchical tissue‐robot interaction and, therefore, can design customized soft robots for different types of tissues with varied mechanical properties. It is shown that these customized robots with different programmable motions can induce precise deformations of porcine muscle, liver, and heart tissues with excellent durability. The soft robots, the underlying design principles, and the fabrication approach provide a new avenue for developing next‐generation mechanotherapy.

Mechanotransduction is a strictly regulated process whereby mechanical stimuli, including mechanical forces and properties, are sensed and translated into biochemical signals. Increasing data demonstrate that mechanotransduction is crucial for regulating macroscopic and microscopic dynamics and functionalities. However, the actions and mechanisms of mechanotransduction across multiple hierarchies, from molecules, subcellular structures, cells, tissues/organs, to the whole‐body level, have not been yet comprehensively documented. Herein, the biological roles and operational mechanisms of mechanotransduction from macro to micro are revisited, with a focus on the orchestrations across diverse hierarchies. The implications, applications, and challenges of mechanotransduction in human diseases are also summarized and discussed. Together, this knowledge from a hierarchical perspective has the potential to refresh insights into mechanotransduction regulation and disease pathogenesis and therapy, and ultimately revolutionize the prevention, diagnosis, and treatment of human diseases. [ABSTRACT FROM AUTHOR]

The application of lipid‐based nanoparticles for COVID‐19 vaccines and transthyretin‐mediated amyloidosis treatment have highlighted their potential for translation to cancer therapy. However, their use in delivering drugs to solid tumors is limited by ineffective targeting, heterogeneous organ distribution, systemic inflammatory responses, and insufficient drug accumulation at the tumor. Instead, the use of lipid‐based nanoparticles to remotely activate immune system responses is an emerging effective strategy. Despite this approach showing potential for treating hematological cancers, its application to treat solid tumors is hampered by the selection of eligible targets, tumor heterogeneity, and ineffective penetration of activated T cells within the tumor. Notwithstanding, the use of lipid‐based nanoparticles for immunotherapy is projected to revolutionize cancer therapy, with the ultimate goal of rendering cancer a chronic disease. However, the translational success is likely to depend on the use of predictive tumor models in preclinical studies, simulating the complexity of the tumor microenvironment (e.g., the fibrotic extracellular matrix that impairs therapeutic outcomes) and stimulating tumor progression. This review compiles recent advances in the field of antitumor lipid‐based nanoparticles and highlights emerging therapeutic approaches (e.g., mechanotherapy) to modulate tumor stiffness and improve T cell infiltration, and the use of organoids to better guide therapeutic outcomes. [ABSTRACT FROM AUTHOR]

One of the most serious sports injuries, injuries in accidents and severe work accidents is the O'Donoghue Triad, which is a multiligamentous injury to the knee joint. Includes rupture of the anterior cruciate ligament, meniscus, and medial collateral ligament. It is also called the "Unfortunate Triad", “Unhappy Triad” due to the fact that a large percentage of athletes with this injury do not return to the sport. Recovery after surgical treatment is about one year. Static instability in the knee joint recovers immediately after surgery, but dynamic instability persists for months after ligament reconstruction. One of the causes of dynamic instability of the knee complex is the suppressed strength capabilities of the periarticular muscles, one of which is m. quadriceps femoris. Purpose: The purpose of this study is to establish the effectiveness of an experimental model of kinesitherapy for recovery the static strength endurance of m. quadriceps femoris, after arthroscopic treatment of O'Donoghue's triad. Methodology: 70 patients with "O'Donoghue's triad" were studied after surgical treatment in the subacute postoperative period, of which 32 were included in the control group (CG) and 38 in the experimental group (EG). To assess the condition and recovery of static muscle endurance of m. quadriceps femoris was tested twice, before and after ten days of kinesitherapy in CG and EG. Test of the static muscular endurance of the m. quadriceps femoris: the patient is in the starting position supine, the tested leg is extended at the knee joint and raised 30 cm from the support. The retention time (until failure) in the set position (in sec.) is counted. In the measurements, a normative limit of up to 4 minutes of isometric loading (240 sec) was adopted. The differences in the data of the healthy and damaged limb (in sec) were subjected to statistical processing and analysis. An experimental model of kinesitherapy applied in EG was developed, and a traditional model was applied in CG. Results: The results of the study show that on the 1st day, the average difference in strength endurance of healthy-injured leg of CG patients is 101.375+48.938 sec. The representative error is mx=12.2 sec. Variability of results V%=48.27%. After ten days of kinesitherapy, the difference in static strength endurance decreased to 67.5 seconds. or in absolute values the decrease is by 33.875 sec., and in relative values the difference has decreased by 33.416%. The results in the EG show a high mean difference in the static power endurance of the leg of 104.947+50.378 sec. on the first day of the study. The representative error is mx=11.558 sec. The variability of the results in the EG on the 1st day is V%=48.0%. After applied experimental kinesitherapy in EG, the static strength endurance of the injured leg drastically improved and the difference with the healthy leg decreased by 79.689% or in absolute values by 83.632 sec (in CG by 33.416%). The mean values of the healthy-injured leg difference on the X-th day decreased to 21.316 sec. Conclusions: From the testing of hypotheses, it is established that on the first day of the study, the difference in the average values of the indicator in CG and EG are statistically insignificant (P=1.000). At the end of the study on the tenth day, the difference found was significant (P=0.002) and the better results in the EG indicated a higher effectiveness of the experimental model of kinesitherapy to improve the static strength endurance of the m. quadriceps femoris, after surgical treatment of "O'Donoghue's Triad", compared to the traditional model of kinesitherapy, which is why we recommend it for practice. [ABSTRACT FROM AUTHOR]

Although interdental papillae play an important role in cosmetic dentistry, there is no predictable surgical technique for reconstructing lost papillae. However, orthodontic measures are often appropriate and successful, provided proper diagnosis and mechanotherapy are applied. This article offers orthodontic alternatives that involve careful manipulation of tooth position to reconfigure the papilla to fill the gingival embrasure. Clinicians should analyze and determine the nature and direction of the tooth movement that will prove most beneficial in each situation, then correctly employ orthodontic mechanotherapy to obtain the desired outcome. [ABSTRACT FROM AUTHOR]

Traditional Chinese exercise ("TCE" management modalities), including but not limited to Tai Chi, Baduanjin, and Yijinjing, has a good effect on improving the physical function of patients with knee osteoarthritis, but less attention has been paid to the impact on the psychological health of patients, and currently there is insufficient evidence to support it. We conducted this study to provide a systematic synthesis of best evidence regarding the physical and mental health of patients with knee osteoarthritis treated by traditional Chinese exercise. Literature on the effectiveness of traditional Chinese exercise (Tai Chi, Baduanjin, Yijinjing, Qigong, etc.) versus conventional therapy (muscle‐strength training of the lower extremity and aerobic training, wellness education, quadriceps strengthening exercises, etc.) on Western Ontario and McMaster Universities Arthritis Index (WOMAC), visual analog scale (VAS), Short Form‐36 (SF‐36), Timed Up and Go Test (TUG), and Berg Balance Scale (BBS) in knee osteoarthritis (KOA) from Pubmed, Web of Science, Ovid Technologies, China National Knowledge Infrastructure (CNKI), Chinese Science and Technology Periodical Database (VIP), Wanfang Database, and SinoMed were collected from their inception to April 2022. Thirty‐three studies with 2621 cases were included in this study. The study's results indicated that compared with conventional therapy, traditional Chinese exercise had more advantages on patients' WOMAC score, significantly reducing patients' overall WOMAC score (SMD = −0.99; 95% CI: −1.38, −0.60; p < 0.00001) and relieving pain (SMD = −0.76; 95% CI: −1.11, −0.40; p < 0.0001) in patients with KOA. It also has advantages over conventional therapy in improving mental component score (MCS) (SMD = 0.32; 95% CI: −0.00, 0.65; p = 0.05) and physical component score (PCS) (SMD = 0.34; 95% CI: 0.05, 0.62; p = 0.02). Compared with conventional therapy, traditional Chinese exercise can significantly reduce the effect on timed up and go test (TUG) score (SMD = −0.30; 95% CI: −0.50, −0.11; p = 0.002), beck depression inventory (DBI) score (SMD = −0.62; 95% CI: −1.03, −0.22; p = 0.002), and increase the impact on Berg Balance Scale (BBS) score (SMD = 0.60; 95% CI: 0.37, 0.83; p < 0.00001). The findings of this study indicated that traditional Chinese exercise improved body function and mental health in patients with knee osteoarthritis significantly. More high‐quality clinical evidence‐based data was needed to confirm the therapeutic effect of traditional Chinese exercise on the physical and mental health in KOA patients. [ABSTRACT FROM AUTHOR]

Background: Systemic sclerosis (SSc) is a chronic autoimmune disease of the connective tissue. Physical training as a planned activity can delay the process of disease changes. The aim of the study is to assess the effectiveness of kinesitherapy conducted in a group of patients with SSc based on a literature review. Material and methods: The PubMed and Pedro databases were analyzed using the following keywords: "systemic sclerosis and physiotherapy or physical training". The university multi-search engine was also used, including the database of periodicals of the Medical University of Silesia in Katowice. Results: Nine works out of 23 articles presenting the impact of various forms of training and physiotherapy methods in the treatment of people with SSc were qualified for the analysis. Conclusions: The conducted analysis of the literature on physical training in people with SSc confirms the advisability of its use with the use of interval training and resistance training. These forms of training have a positive effect on the functions of the respiratory, circulatory and muscular systems. Physical training can be a valuable supplement to pharmacotherapy to support the treatment of this group of patients. [ABSTRACT FROM AUTHOR]

Conventional scar treatment options of single pressure garment therapy (PGT) or silicone gel sheeting (SGS, Cica-Care®, Smith and Nephew, London, UK) alone lack mechanical property tunability. This article discusses a scar healing composite (PGF-Biopor®AB, Dreve Otoplastik GmbH, Unna, Germany) and how its mechanical properties can be tuned for improved mechanotherapy. A balance between compression and tension was achieved by tuning the tensile and shear properties, facilitating tension shielding and pressure redistribution for scar therapeutics. Biopor®AB-wrapping on biaxial-tensioned pressure garment fabric (PGF) allowed compression therapy and internal pressure redistribution. The Biopor®AB surface, with a coefficient of friction close to 1, strategically localizes stress for effective tension shielding. A substantial five-fold reduction in silicone tension, amounting to 1.060 N, achieves tension shielding and pressure redistribution. Simultaneously, a dynamic internal pressure-sharing mechanism distributes 0.222 kPa from each SPK-filament bundle, effectively managing internal pressure. Alongside the principle compression-silicone dual therapy, this composite design with dynamic internal pressure sharing and mechanical property tunability provides an additional pressure-relieving strategy for multiple scar therapeutics. [ABSTRACT FROM AUTHOR]

The complexity of the movements of the bones of the knee joint requires an anatomical study to construct a knee prosthesis. The reasons for knee replacement are related to wear of the articular cartilage, which leads to pain, deformation, and limitation of movements. The consequences of the surgical intervention allow functional restoration of the knee joint and the supporting function of the lower limb. Kinesitherapy begins the day after surgery and aims to reduce pain, restore mobility of the knee joint, actively lock the knee during extension, increase and maintain muscle strength, and ensure the functional independence of patients. To a large extent, the volume of movement is restored, and the pain symptoms are reduced. Patients have the comfort of everyday movements and the possibility of participating in certain sports activities-swimming, cycling, and golf. The paper deals with pharmacological prophylaxis, the kinesitherapeutic program, and total knee arthroprosthesis. [ABSTRACT FROM AUTHOR]

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Over the past 2 decades, cancer stem cells (CSCs) have been identified as the root cause of cancer occurrence, progression, chemoradioresistance, recurrence, and metastasis. Targeting CSCs is a novel therapeutic strategy for cancer management and treatment. Liver cancer (LC) is a malignant disease that can endanger human health. Studies are increasingly suggesting that changes in the liver mechanical microenvironment are a primary driver triggering the occurrence and development of liver cancer. In this review, we summarize current understanding of the roles of the liver mechano-microenvironment and liver cancer stem cells (LCSCs) in liver cancer progression. We also discuss the relationship between the mechanical heterogeneity of liver cancer tissues and LCSC recruitment and metastasis. Finally, we highlight potential mechanosensitive molecules in LCSCs and mechanotherapy in liver cancer. Understanding the roles and regulatory mechanisms of the mechano-microenvironment and LCSCs may provide fundamental insights into liver cancer progression and aid in further development of novel therapeutic strategies.

Physiotherapy is the science that studies the mechanisms of action of physical factors such as massage, exercise, water, light, heat, electricity, and their use for therapeutic purposes to treat, recover and prevent inflammatory or degenerative diseases. Physiotherapy is a complex discipline comprising several branches: hydrotherapy, laser therapy, electrotherapy, kinesitherapy, massage and balneotherapy. The most commonly used method is laser therapy, especially in patients with pain of various causes and localization, inflammation of tendons or soft tissues (tendinitis, bursitis), joint pain, ulcers, bedsores, vicious scars, but also in the treatment of neurological problems of the spine. The second method used is cutaneous electrical stimulation, the benefits of which are long-lasting muscle relaxation, better nerve conduction, improved circulation to adjacent tissues, and pain control through the release of endorphins (analgesic effect). [ABSTRACT FROM AUTHOR]

The purpose of the study: to study the effectiveness of active medical rehabilitation technologies among Paralympians engaged in playing sports.Materials and methods: examined 48 male patients aged 25.9 ± 2.1 years with traumatic disease of the lumbar spinal cord. All examined were divided into 2 groups: patients of the main group (19 people) against the background of standard therapy received a course of active medical rehabilitation (AMR), including mechanotherapy and electrical stimulation with biofeedback under the control of electromyography (EMG) of the muscles of the lower extremities and back. Patients in the comparison group (29 people) received standard therapy. After the AMR course, a comprehensive examination was performed, including the data of the questionnaires: the ASIA classification (American Spinal Injury Association), the FIM (Functional Independence Measure) scale of functional independence, the modified functional assessment scale of activity and quality of life VFM (Valutazione Funzionale Mielolesi), State-Trait Anxiety Inventory, the Beck depression scale; electroneurophysiological studies on the Neurosoft Neuro-EMG-Micro device, heart rate variability (HRV) on the Neurosoft Poly-Spectrum computer electrocardiograph, indicators of free movement with concentric and eccentric muscle contractions on EN-TreeM.Results: polysympathetic reflex excitability (PRV) significantly decreased in patients of the main group. There was also an improvement in vegetative reactivity (coefficient 30/15 is 1.45; p

Abstract Mechanotransduction is a strictly regulated process whereby mechanical stimuli, including mechanical forces and properties, are sensed and translated into biochemical signals. Increasing data demonstrate that mechanotransduction is crucial for regulating macroscopic and microscopic dynamics and functionalities. However, the actions and mechanisms of mechanotransduction across multiple hierarchies, from molecules, subcellular structures, cells, tissues/organs, to the whole‐body level, have not been yet comprehensively documented. Herein, the biological roles and operational mechanisms of mechanotransduction from macro to micro are revisited, with a focus on the orchestrations across diverse hierarchies. The implications, applications, and challenges of mechanotransduction in human diseases are also summarized and discussed. Together, this knowledge from a hierarchical perspective has the potential to refresh insights into mechanotransduction regulation and disease pathogenesis and therapy, and ultimately revolutionize the prevention, diagnosis, and treatment of human diseases.

Peripheral nerve injuries lead to significant morbidity and adversely affect quality of life. The peripheral nervous system harbors the unique trait of autonomous regeneration; however, achieving successful regeneration remains uncertain. Research continues to augment and expedite successful peripheral nerve recovery, offering promising strategies for promoting peripheral nerve regeneration (PNR). These include leveraging extracellular vesicle (EV) communication and harnessing cellular activation through electrical and mechanical stimulation. Small extracellular vesicles (sEVs), 30–150 nm in diameter, play a pivotal role in regulating intercellular communication within the regenerative cascade, specifically among nerve cells, Schwann cells, macrophages, and fibroblasts. Furthermore, the utilization of exogenous stimuli, including electrical stimulation (ES), ultrasound stimulation (US), and extracorporeal shock wave therapy (ESWT), offers remarkable advantages in accelerating and augmenting PNR. Moreover, the application of mechanical and electrical stimuli can potentially affect the biogenesis and secretion of sEVs, consequently leading to potential improvements in PNR. In this review article, we comprehensively delve into the intricacies of cell-to-cell communication facilitated by sEVs and the key regulatory signaling pathways governing PNR. Additionally, we investigated the broad-ranging impacts of ES, US, and ESWT on PNR.

Abstract The application of lipid‐based nanoparticles for COVID‐19 vaccines and transthyretin‐mediated amyloidosis treatment have highlighted their potential for translation to cancer therapy. However, their use in delivering drugs to solid tumors is limited by ineffective targeting, heterogeneous organ distribution, systemic inflammatory responses, and insufficient drug accumulation at the tumor. Instead, the use of lipid‐based nanoparticles to remotely activate immune system responses is an emerging effective strategy. Despite this approach showing potential for treating hematological cancers, its application to treat solid tumors is hampered by the selection of eligible targets, tumor heterogeneity, and ineffective penetration of activated T cells within the tumor. Notwithstanding, the use of lipid‐based nanoparticles for immunotherapy is projected to revolutionize cancer therapy, with the ultimate goal of rendering cancer a chronic disease. However, the translational success is likely to depend on the use of predictive tumor models in preclinical studies, simulating the complexity of the tumor microenvironment (e.g., the fibrotic extracellular matrix that impairs therapeutic outcomes) and stimulating tumor progression. This review compiles recent advances in the field of antitumor lipid‐based nanoparticles and highlights emerging therapeutic approaches (e.g., mechanotherapy) to modulate tumor stiffness and improve T cell infiltration, and the use of organoids to better guide therapeutic outcomes.

Introduction In individuals with Class II malocclusions, there is an anteroposterior discrepancy between the maxillary and mandibular dentitions, which may or may not be accompanied with a skeletal discrepancy, the most effective treatment option to eliminate is by modified three piece base arch combined with TADS for simultaneous deep bite correction and en masse retraction. Aim The present case report showcases the treatment results and biomechanics involved for en masse retraction and intrusion of anterior teeth using three-piece intrusion arch and temporary anchorage device. Conclusion The modified three piece base arch combined with TADS is effective in controlled translation and intrusion of anteriors and would be a preferable mechanotherapy in low angle case with deep bite, proclined anterior and Class II malocclusion. [ABSTRACT FROM AUTHOR]

[Display omitted] Administration of focused ultrasounds (US) represents an attractive complement to classical therapies for a wide range of maladies, from cancer to neurological pathologies, as they are non-invasive, easily targeted, their dosage is easy to control, and they involve low risks. Different mechanisms have been proposed for their activity but the direct effect of their interaction with cell membranes is not well understood at the molecular level. This is in part due to the difficulty of designing experiments able to probe the required spatio-temporal resolutions. Here we use Molecular Dynamics (MD) simulations at two resolution levels and machine learning (ML) classification tools to shed light on the effects that focused US mechanotherapy methods have over a range of lipid bilayers. Our results indicate that the dynamic-structural response of the membrane models to the mechanical perturbations caused by the sound waves strongly depends on the lipid composition. The analyses performed on the MD trajectories contribute to a better understanding of the behavior of lipid membranes, and to open up a path for the rational design of new therapies for the long list of diseases characterized by specific lipid profiles of pathological membrane cells. [ABSTRACT FROM AUTHOR]

Background The Basas Spanish Squat with electrical stimulation (E-stim) has shown promising results as a potential key exercise in treatment of athletes with patellar tendinopathy. Gold standard exercise therapy for tendon injuries consists of tendon loading exercises, or exercises that appropriately applies high levels of mechanical strain to the tendon. The theoretical pathway in which the Basas Spanish Squat with E-stim improves tendinopathy has been speculated to be the additional strain applied through the patellar tendon during superimposition of E-stim. This theory, however, has yet to be confirmed. Purpose The purpose of this case series was to compare patellar tendon strain, during the Basas Spanish Squat with, and without E-stim, and open kinetic chain knee extension. Methods Four healthy participants performed the three exercises while a physical therapist collected simultaneous unilateral ultrasound images from the patellar tendon. Strain was calculated as the change in patellar tendon length during contraction divided by the resting length. Results Amongst all participants, patellar tendon strain was smallest during the Basas Spanish Squat without E-stim, followed by the open kinetic chain knee extension at 60% maximum voluntary isometric contraction. The Basas Spanish Squat with E-stim yielded approximately double or more strain compared to the without E-stim condition and demonstrated higher level of strain compared to open kinetic chain knee extension in all participants. Conclusion The findings reflect a clear trend of increased strain through the patellar tendon when E-stim was superimposed. The results support the theory that the Basas Spanish Squat with E-stim increases patellar tendon strain and could explain the reported clinical benefits in individuals with patellar tendinopathy. Level of Evidence 4, Case series [ABSTRACT FROM AUTHOR]

The lifetime prevalence of nonspecific low back pain in developed countries is 60%-70%. Low back pain, also called lumbago, radiculitis, is one of the most common musculoskeletal complaints causing musculoskeletal dysfunction. Globally, about 40% of people suffer from persistent low back pain at some point in their lives. Women have been shown to suffer from such changes more often than men. According to a study carried out by Global Burden of Disease (2019), low-back syndrome falls in the top ten diseases leading to temporary disability. The purpose of the study was to follow the effect of an adapted "30 minute home exercise program"- with kinesitherapy techniques on pathologies in the lumbar region and especially on the main symptom, namely pain. Improving the stability of the pelvic ring, as well as the good condition of the muscles in the small pelvis and those responsible for movements in the hip joints determine the condition of the mobile segments and contractile structures in the lower spine, the pelvic ring and the pendular apparatus. Methodology. Twenty-nine people were studied, of whom 27 completed the full program – 5 men and 22 women. Four control treatments were conducted, at equal intervals, over a two-week (14 days) period. On the remaining 10 days, the patients were instructed to perform the gymnastics at home. We used two tests to monitor the effectiveness of the program: the "Visual Analogue Scale" and the "10 Step Time Test" (measured in seconds, adapted by us). The measurements were performed at the beginning and at the end of the treatment period. The program contains 17 exercises divided into 4 groups in a specific sequence. Results: At the end of the two-week period, each participant reported improvement in the general condition, reduction of the pain, mobility and reduced fatigue. The overall results of the two tests showed a reduction in the values of the "Visual Analogue Scale" - by one unit and a reduction in the performance time in the "10-step test" - adapted by us. Conclusion: The therapeutic program consisting of 17 exercises is sufficient to relieve pain in the lumbar region. The values from both tests demonstrate also an ease in ambulation, which would respectively improve the quality of life and the performance of daily activities in patients. The average duration of the program was about 30 minutes. The preventive effects, including psychological effects, of rehabilitation on life styles to form behavioral stereotypes and optimal benefits for socialization are discussed. Essential criteria for the leading role of physical activity are outlined. As a result of data and research from leading institutions, traditional and contemporary views are discussed, as well as specific implemented models for its maintenance, dosed according to age and health status; the promoting effects against various diseases are indicated. Attention is given to activities equivalent to sporting elements, including effects on quality of life. Recommendations: A longer study of the test group and a repeat study to verify the effectiveness of the program are required to validate its effectiveness. [ABSTRACT FROM AUTHOR]

Rupture the front one crossed ACL ligaments are mostly mentions the code active and young people an athlete and can to have permanent psychological and physical consequences. Clinical assessment and treatment injuries it is broad research thesis in orthopedics. ACL injury most often as a result by contact and contactless principle, that is the first is more common the code male half, while the other a lot more common the code a woman. Mentioned injury most commonly be surgical taken care of, also characterizes it relatively high rate permanent rupture. The result be displayed psychological load for athletes like and long-term weather period rehabilitation. Goal research: Determine efficiency physiotherapy in rehabilitation after injuries front ones crossed ligaments which includes surgery reconstruction by application physical therapy and kinesitherapy. Method of work: The search included review relevant base data: Medline, PabMed, Google Scholar, Research Gate. By display 8 randomized studies were included in the literature review clinical research. Based on of which it was made plan view and program rehabilitation an athlete after injury the front one crossed ligament, the efficiency program physical therapy and kinesitherapy. Research rehabilitation an athlete the code injury to the anterior cruciate ligament is nonexperimental qualitatively research, that is scientific literature review. Results: Research on efficiency is presented procedure physical therapy and kinesitherapy in rehabilitation an athlete after injuries the front one crossed ligament. Conclusion: Rehabilitation athlete (physical therapy and kinesitherapy) give significant results in sense reduction pain, increase volume movement and strength muscles after ACL injuries. [ABSTRACT FROM AUTHOR]

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PURPOSE: The aim of the study is to monitor the effect of a specialized kinesitherapy program on motor development in a child with achondroplasia. METHODS: The study cohort was 1 infant with achondroplasia. The infant had physical therapy sessions 5 times a week with a physical therapist and/or with his parents who were trained in kinesitherapy techniques. Specialized kinesitherapy contained specialized methods for working with children and modifications of methods. For the purposes of the study, we applied the following research methods: research of literature sources; examination of gross motor functions using the Gross Motor Function Measure-88 method; mathematical and statistical methods. RESULTS: We reported a statistically significant improvement in the results of the conducted motor function testing. CONCLUSIONS: Analysis of the results showed that specialized kinesitherapy was effective in improving gross motor skills in an infant with achondroplasia. We believe that specialized kinesitherapy is the main method of therapy for children with hypotonia caused by various pathologies. The early inclusion of kinesitherapy, the regular conduct of kinesitherapeutic procedures and the correctly selected methodology are of key importance for the effect of the therapy. [ABSTRACT FROM AUTHOR]

Hallux valgus, or the so-called "bunions", is a common joint deformity that can seriously affect the foot's function. The current case study presents the influence of physiotherapy tools on a 43-year-old woman with bilateral hallux valgus. The diagnostic methods used are current status, functional tests, and measuring deformation angles and plantar indices on the simple footprint (plantogram). The therapy includes passive means (separation of the fingers, corrective Kinesio taping, stretching exercises) and active ones - specific, corrective and strength exercises. Conducted kinesitherapy leads to pain relief and partial correction of the deformity. The present case may serve as a basis for further, more in-depth studies. [ABSTRACT FROM AUTHOR]

Research objectives: specify the framework of using cutting-edge approaches and innovations in the training of rehabilitation physicians; investigate existing innovative technologies; get an insight into the motivation of students majoring in rehabilitation when working with the Gross simulator in sports rehabilitation of patients. The research was conducted at a mixed-type rehabilitation center for disabled adults and children at Soochow University in China. The study was conducted among 200 students majoring in rehabilitation at Soochow University and 100 children from a rehabilitation center with motor disorders: 50 boys and 50 girls. The patients were aged 4-6 years, and the average age of the participating students was 21 years. The students were offered a 6-month training course in rehabilitation of patients with musculoskeletal disorders, by using innovative technology—the Gross simulator. Student motivation analysis yielded the following outcomes: 90% of the students said that training to operate simulators is useful for the rehabilitation specialist, because this affects the proficiency of such specialist; 15% of students reported they did not like innovative technology in teaching because they faced difficulties in understanding it; 80% of students believed such technology facilitated the learning, and 5% of students were neutral. Further studies, conducted on clinical research sites, might address the effectiveness of training rehabilitation specialists, the use of cutting-edge simulators and robotic systems, as well as development of rehabilitation protocols for patients with injuries and musculoskeletal disorders. [ABSTRACT FROM AUTHOR]

Background: The restoration of motor function and stability is a critical aspect of stroke rehabilitation. Purpose: To design a research protocol and evaluate the effect of using robotic kinesitherapy with the Locomat "Kinisiforo" to improve locomotor skills and stability in stroke patients in the chronic recovery phase. Material and methods: The randomised study was conducted at the NBPTR - Ovcha Kupel in 19 patients with ischaemic stroke (10 patients in the experimental group (EG), mean age 76.75±6.89 years and 9 in the control group (CG), mean age 73.69±6.89 years). The subjects underwent a 4-week kinesitherapy programme. The evaluations before and after the kinesitherapy were carried out with prepared protocol, including 3 selected tests suitable for implementation in clinical conditions. The kinesitherapy programme was carried out every day for all subjects, and the participants in the EG also exercised with the "Kinisiforo" locomat. The effect of robotic kinesitherapy on stroke patients was evaluated in comparison with the CG, which received routine kinesitherapy. Results: The study showed a statistically significant improvement in step count, walking time, gait stability and minimisation of fall risk. The Timed Up and Go (TUG) test also showed a statistically significant improvement in mobility and balance, with higher scores in the experimental group. The Rivermead Mobility Index and Joint Position Sense scores, which we included in the protocol, were also higher in patients who received locomotion training. After standard kinesitherapy, no significant changes were observed in the monitored individuals. Conclusion: This study shows that the use of robotic kinesitherapy with the Kinisiforo" locomat improves functional outcomes and significantly minimises the risk of falls in patients recovering from stroke. [ABSTRACT FROM AUTHOR]

The aim of the research is to study the effect of extension therapy in improving the mobility of the spine in the most common vertebral syndromes Contingent and methods: 22 patients (11 men and 11 women) aged 35 to 50 years with diagnosed vertebral syndromes were included in the research study. During the rehabilitation, a functional test is applied - goniometry. Measurements are carried out at the beginning of the rehabilitation, in the middle and at the end of the treatments. According to the localization of the extension during the application, it is cervical or lumbar, horizontal or vertical along the axis of the body, and according to the method of traction it can be static, intermittent and/or cyclic. The method of application differs depending on whether cervical or lumbar extension is applied. Results: From the processed data results are obtained for a significant improvement of the range of movements in the cervical and thoracic region. Conclusion: Kinesitherapy and methodological guidelines for strengthening the paravertebral, abdominal and gluteal muscles in combination with electrotherapy which has a main analgesic effect and a combination with extension therapy can lead to significant changes in terms of increasing the amplitude of movement in the affected joints of the spine. [ABSTRACT FROM AUTHOR]

Mechanotherapy is a groundbreaking approach to impact carcinogenesis. Cells sense and respond to mechanical stimuli, translating them into biochemical signals in a process known as mechanotransduction. The impact of stress on tumor growth has been studied in the last three decades, and many papers highlight the role of mechanics as a critical self-inducer of tumor fate at the in vitro and in vivo biological levels. Meanwhile, mathematical models attempt to determine laws to reproduce tumor dynamics. This review discusses biological mechanotransduction mechanisms and mathematical-biomechanical models together. The aim is to provide a common framework for the different approaches that have emerged in the literature from the perspective of tumor avascularity and to provide insight into emerging mechanotherapies that have attracted interest in recent years. • This work discusses the therapeutic potential of some known mechanotransduction signaling pathways in cancer treatment. • The article describes and mechanically classifies the forces that are exerted on a growing tumor and its microenvironment. • We review avascular tumor growth models that account for mechanotransduction. • The review provides insights into emerging mechanotherapies that are gaining interest in recent years. [ABSTRACT FROM AUTHOR]

Introduction and aim. Researching inherited polyneuropathy is vastly topical in the course of the contemporary practice of physical therapy and ergotherapy. The article unveils the results of the application of kinesitherapy in the process of rehabilitation of patients with Charcot-Marie-Tooth nerval amyotrophia. Inherited Charcot-Marie-Tooth neuropathy is a genetical disease, which is manifested with the slow reduction of the size of muscles of limbs and weakening of distal locations, is the most widespread clinical form of inherited polyneuropathies, which affect people regardless of generational and gender-based; mostly young and workable people become the objects suffering from its impact. Description of the case. Due to the relatively low frequency of the multiplication of the disease within the population (according to the data from clinical statistics, the prevalence of all types of Charcot-Marie-Tooth amyotrophia per 100 thousand people is approximately 36 cases) four patients with Charcot-Marie-Tooth nerval amyotrophia aged in the area from 14 to 20 years took part in the research. In the course of the research, we applied the method of electroneuromyography, which provided the opportunity of detecting the rate of impulse impact via afferent and efferent ways, the duration of M-response and the number of movable entities within lower limbs. Conclusion. As a result of classes being held and carried out according to the experimental kinesitherapy study program, there was the detection of positive tendencies of changing the psychophysical state of patients, diagnosed with "Charcot- -Marie-Tooth nerval amyotrophia". [ABSTRACT FROM AUTHOR]