88 results on '"MASSARELLI, O."'
Search Results
2. Computer assisted dental rehabilitation in free flaps reconstructed jaws: one year follow-up of a prospective clinical study
- Author
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Meloni, S.M., De Riu, G., Pisano, M., Massarelli, O., and Tullio, A.
- Published
- 2012
- Full Text
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3. SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study
- Author
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COVIDSurg Collaborative, GlobalSurg Collaborative, A, M., Abdelhamid, M. H. S., Alhabdan, S., Nekoval, V., Nel, C., Nel, D., Nel, H., Nelihela, P., Nelissen, E., Nelli, T., Nelson, C., Nemeth, M., Nene, A., AlHADAD, M., Neo, E. L., Neo, E. N., Neri, C. M., Neshige, S., Nespoli, L. C., Nessa, A., Nessim, C., Neuerburg, C., Neves, F., Neves, M., Alhaddad, A., Newcomb, A., Newitt, L., Newman, J., Newman, M., Newman, S., Newton, L., Neykov, V., Nezerwa, Y., Nezi, G., Ng, B., Alhaddad, W., Ng, C. S. H., Ng, C. F., Ng, C. E., Ng, D., Ng, D. S. W., Ng, J. C. K., Ng, J. Y., Ng, J., Ng, K. K., Ng, K. C., Alhadeethi, A., Ng, M. Y., Ng, M., Ng, S., Ng We Yong, Y. J., Ng-Kamstra, J., Ngan, T. Y., Ngaserin, S., Ngeruka, M. L., Ngu, J., Alhadi, A., Ngulube, A., Nguyen, A., Nguyen, H. M. N., Nguyen, H., Nguyen, S., Ni Bhroin, O., Nia, A., Niazi, F. A. K., Niazi, M., Alhag, A., Niazi, S. U., Nichani, J., Nichita, M., Nicholas, E., Nicholson, K., Nicholus, M., Nicolaiciuc, S., Nicolas, B., Nicolás-López, T., Niculae, C., Alhaidari, A., Nidaw, M., Nielsen, M. F., Niemeier, A., Nieto Calvache, A. J., Nieto Rodriguez, J. M., Nieto-Moreno, A., Nieto-Moreno, E., Nigalye, N., Nikaj, H., Nikiteas, N., Alhaje, A., Nikolai, K., Nikolaieva, K., Nikolic, S., Nikoloudaki, Z., Nikolouzakis, T., Nikolovska, B., Nikoupour, H., Nikova, A., Nimako, B., Nimako-Mensah, J., Alhajji, Z., Nimale, S., Nimer, B., Ninan, J. E., Ninic, A., Ninkovic, M., Niño Corredor, R. A., Niquen-Jimenez, M., Nirgude, A., Niriella, S., Nisa, K., Abdeljalil, A., AlHajri, N., Nischwitz, S. P., Nishihara, N., Nishikawa, K., Niska, K., Nistor-Ciurba, C. C., Nitschke, C., Nixon, A., Niyongombwa, I., Nizami, M., Niziol, R., Alhakami, N., Njeze, N., Njim, T., Njuki, P. N., Nk, V., Nkole, T., Nkrumah, J., Nkubito, J. M. S., Nkunzimana, E., Nabugwu, I., Najiuba, H., Alhalal, H., Noah, K., Nocera, G., Noda, M., Noe, C., Noel, C., Noël, A., Nofal, S., Noguchi, H., Nogueiro, J., Noguera Roman, L., Alhamid, A., Nogués, A., Noguez Castillo, M., Noiret, B., Nolan, D., Noll, F., Nolte, P., Noltes, M., Noman, H., Nomura, T., Noone, A., Noor, A., Noor, D. F., Noor Mohamed, M. S., Noordin, S., Noori, E., Noori, F., Norawat, R., Nordberg, M., Noreen, D. Z., Noriega, D. C., Alhamid, M., Norman, L., Noro, S., Noronha, W. J., Norouzi, S., Norris, J., Norrish, A., Nortey, M., Norton, J., Norton, S., Norton, W., Alhammad, O., Notario, J., Noton, T., Notz, Q., Nouh, T., Noureen, D. S., Noureldin, Y., Novak, Z., Novello, S., Novembre, D., Novi, A., Alhammali, T., Novikov, D., Novikova, A., Novoa, B., Novotny, H. F. G., Novysedlák, R., Nowak, K., Nowar, M., Nowosielski, Y., Nsaful, J., Nshuti, S., AlHarazi, A., Ntaganda, E., Ntalouka, M., Ntege, A., Ntege, J., Ntezamizero, J., Ntirenganya, F., Ntoto, M. C. O., Ntziovara, A. M., Nubair, S., Nugent, T., Alharthi, B., Nugur, A., Nuh, A., Nunes, R., Nunes, S., Nunes Coelho, M., Nunez, J., Nuñez, J., Nuñez, R., Núñez, A., Núñez, B., Abdelkabir, M., Alharthi, M., Nuñez Del Barrio, H., Núñez Lucic, J., Núñez O'Sullivan, S., Nunez-Garcia, B., Núñez-González, RÁ, Nuño-Escobar, C., Nurgozhin, T., Nuseir, A., Nwabuoku, S. E., Nwachukwu, C., Alharthi, N., Nwachukwu, I., Nwafor, I., Nwagboso, C., Nwaorgu, O., Nwashilli, N., Nwegbu, C., Nwinee, H., Nwosu, D., Nyadu, B., Nyangoh Timoh, K., Alharthi, S., Nyarko, O. O., Nyarko Agyeman, Y., Nyeko-Lacek, M., Nygaard, R. M., Nyirahabakurama, D., Nyirahabimana, J., Nyirimodoka, A., O Connor, C., O'Banion, L. A., O'Brien, S., Alhasan, H., O'Connell, E., O'Connell, R., O'Connor, B., O'Connor, D. B., O'Connor, J., O'Connor, Z., O'Donnell, R., O'Donoghue, C., O'Donoghue, G., O'Farrell, E., ALhassan, A., O'Grady, M., O'Hagan, P., O'Kelly, J., O'Mara-Gardner, K., O'Neill, A., O'Neill, C., O'Neill, R., O'Shea, M., O'Sullivan, E., Obadan, I., Alhassan, B. A. B., Obahiagbon, O., Obaid, K., Obaid, M., Obara, S., Obateru, J., Obbeng, A., Obeidat, R., Obied, H., Obrist, C., Obuekwe, O., Alhassan, B., Obure, R., Ocampo, L., Ocampos, L., Ocampos Hernandez, M., Occhionorelli, S., Ochoa Carrillo, F. J., Ochoa Gaete, K., Ochoa Villalabeitia, B., Ocsan, R. J., Od, S., Alhassoun, T., Odai, E. D., Odedra, A., Odeh, A., Odejinmi, F., Odetto, D., Odeyemi, O., Odeyemi, P. O., Odicino, F., Odigie, P. V., Odonnell, E., Alhathal, N., Oduah, S., Odunafolabi, T., Oduola, O., Odutola, O., Offiong, R., Ofori, B., Ofori, E. O., Ofosu-Barko, B. B., Ogawa, M., Ogden, E., Alhattab, M., Ogenya, R., Ogihara, T., Ogu, R., Ogunade, O., Ogundele, I., Ogundoyin, O., Ogunkeyede, S. A., Ogunlaja, O., Ogunrewo, T., Abdelkader Salama, I., Alhawatmeh, M., Ogunsua, O., Oguttu, B., Oğuz, C., Ohama, S., Ohara, R., Ohazurike, E., Oikonomou, K., Ojeda Rojas, A. M., Ojeda Thies, C., Ojeda Villasboa, D. J., Alhazmi, A., Ojewola, R. W., Ojha, B. K., Ojo, O., Okada, H., Okada, R., Okada, S., Okada, T., Okafor, B., Alhazmi, B., Okail, M. H., Okamura, K., Okamura, Y., Okere, O., Okereke, C., Okhakhu, A., Okolie, L., Okonkwo, I., Okoro, K., Okoye, E., Alhazzaa, N., Okoye, O., Okpani, A., Okpani, C., Okugbo, S., Okunade, K., Okunlola, A., Okunowo, A., Okwara, B., Olabinjo, A., Oladejo, T., Alhefdhi, A., Oladiran, A., Olagunju, N., Olajide, A., Olajide, T. O., Olaogun, J., Olaomi, O., Olaosebikan, R., Olaoye, I., Olasehinde, O., Olatoke, S. A., Alhelal, B., Olave Montaño, V. D., Olawoye, O., Olayiwola, D. O., Olaywah, D., Olaywah, N., Oldani, M., Oldbury, M., Oldrà, G., Olea Vielba, C., Olearo, E., Alhelal, F., Olieman, A., Oliva, A. R., Oliva, J. R., Oliva, R., Olive, R., Oliveira, A., Oliveira, J., Oliveira, J. C. C., Oliver, T., Alhemyari, N., Oliver García, L., Oliver Guillen, J. R., Olivos, M., Ollat, D., Oller, I., Olliff, S., Ollivere, B., Olmedo Bareiro, R. I., Olmi, S., Olori, S., Alherabi, A., Olowogbayi, T., Olson, K. A., Olubayo, O. O., Olugbami, A., Oluka, D. D., Olulana, D., Olusanya, A., Olute, A., Oluwafemi, F., Olvera-Flores, O. E., Alhindi, R., Omar, K., Omar, M., Omar, M. W., Omar, N. G., Omar, O. M., Omar, S., Omar, W., Omar Abunaaja, H., Omara, U., Abdelkareem, M., Alhogbani, M., Omari, R. Y., Ombashi, S., Omeje, U. K., Omer, M. E. A., Ömer, ÖA., Ömeroğlu, S., Omigbodun, A., Omiragi, P., Omisanjo, O., Omotosho, P., Alhossaini, R., Omran, J., Onakoya, P., Onate, J., Oñate, M., Önder, A. B., Öney, M. D., Ong, B. S., Ong, C. F., Ong, D., Ong, J. H., Alhouni, T., Ong, L., Ong, M. T. Y., Ong Vaño, A. M., Oni, O., Oni, S., Onjefu, S., Ono, M., Onochie, E., Onorati, I., Onubogu, I. K., Alhouri, A., Onur, I. U., Onwuagha, I., Onyeagwara, N., Onyeji, J., Onyemaechi, N., Onzi, T. R., Oo, A., Ooi, C., Ooi, R., Ooi, S. Z. Y., ALhumaida, A., Oosterlinck, W., Oosterling, S., Oosthuizen, B., Opandoh, I. N. M., Opano, R., Opincans, J., Opoku Amankwaa, W., Oppah, I., Oppong, P. P., Oputa, V., Alhunaidi, O., Orădan, A., Oranu, E., Orazulike, N., Ordemar, J., Ordoñez, S., Organ, N., Organjee, A., Orgoi, S., Orhan, N., Orhan Sungur, M., Alhussaini, A., Orji, I. J., Orji, M., Ormeño, M., Ornaghi, S., Oropeza, M., Orozco-Chamorro, C. M., Orozco-Perez, J., Orsoo, S., Orta Díaz, M. D., Ortega, N., Alhussein, A., Ortega, S., Ortega Oria de Rueda, M., Ortega Vázquez, I., Ortega-Jiménez, J. A., Ortiz, E. V., Ortiz, L., Ortiz, M. R., Ortiz De La Cruz, F., Ortiz de Solórzano Aurusa, F. J., Ortiz López, D., Alhuthayl, M., Ortiz Silva, C., Ortiz Simón, A., Oruç, M., Oryadi Zanjani, L., Osabutey, A., Osagie, O., Osaki, S., Osborn, T., Osborne, L., Oscarsson, A., Ali, A. A. A., Osea, L., Oseghale, E., Osei-Bonsu, P., Osei-Poku, D., Osei-Tutu, E., Osemwegie, O., Osho, P., Osinaike, B., Osl, A., Osman, A., Abdelkarem, M. M., Ali, A. D., Osman, E., Osman, H., Osman, I., Osman, K., Osman, L., Osman, M., Osman, M. F., Osorio, D., Osorio, W. A., Ali, A. A., Ossman, M. A., Osterberg, E. C., Osterhoff, G., Ostrovsky, I. A., Osuna, L., Osuna-Rubio, J., Osuoji, R., Otaif, W., Otayfah, S., Otchwemah, R., Ali, A., Oteem, A., Oter, V., Othieno Misanga, H., Othiyil Vayoth, S., Othman, A., Othman, A. F., Othman, E., Othman, M., Othman, S., Otieno, J., Otify, M., Otiniano Alvarado, C. E., Otokwala, D. J., Ots, R., Otsuka, Y., Ott, J., Otte, H., Ottl, S., Ou, C. X. Y., Ali, A. M., Ouchi, T., Oudrhiri, M. Y., Ouf, A., Ould Si Amar, A., Ourieff, J., Ourô, S., Ousouss, S., Outani, O., Owaimer, R., Owais, Q., Owens, D., Owens, P., Ower, C., Owiedat, M., Owusu Adae, J., Oyama, T., Oyediji, F., Oyelakin, O., Oyeleye, O., Oyelowo, N., Oyende, O., Oyewole, O., Oyewusi, E., Oyinloye, O., Ozair, A., Özant, A., Ozben, V., Özcan, A., Özçay, N., OZcelık, M. F., Ozdemir, E., Ozdemir, K., Özdoğan, K., Özeller, E., Ozgediz, D., Özgen, U., Ozgur, I., Ozkan, O. F., Ozkent, M. S., Ozmen, M. M., Ozone, C., Özpak, S. S., Oztan, M. O., Ozua, J., P B, H., P L, T., Paal, P., Pabari, A., Pablo, C., Pacheco Sánchez, D., Pachl, M., Pacilio, C. A., Pacilli, M., Padilla-Valverde, D., Padmore, G., Páez, W., Pagano, G., Pagano, L., Page, R., Pagès, N., Abdelkarim, M., Ali, D., Pahalawatta, U., Paiano, L., Paiella, S., Paine, W., Pais, J., Paitici, S., Paiva, J., Paiva Vera, D. A., Paiva-Santos, F., Pajan, H., Pajić, S., Pal, U. 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A., Panuganti, V., Panyko, A., Paolini, B., Papa, A., Papaconstantinou, I., Papadia, A., Papadopoulos, V., Papadopoulou, T., Papagni, V., Papalampros, A., Papalexandris, S., Papalia, R., Papandrea, M., Papanikolaou, V., Papas, T., Papatheodorou, P., Papavasiliou, K., Papendick, N., Papidze, K., Pappas, S., Ali, M., Parab, D. M., Parab, S., Parada Rodriguez, A. M., Parakonthun, T., Paramasivan, A., Páramo Zunzunegui, J., Paranjape, C., Paraskevas, K. I., Paraskevopoulos, K., Pardes, R., Pardilho, A., Pardiwala, D., Paredes, I., Paredes, S., Paredes Caturiny, A., Pareed, D. D., Pareek, P., Pareja Ciuro, F., Parekh, J. N., Parello, A., Parente, A., Parfitt, C., Pargal, D. P., Parija, S., Paris, M., Park, A., Park, C., Park, F., Park, J. J., Park, J., Park, M., Park, P., Park, S. S. W., Parker, D., Parker, K. L., Parker, M. Y., Parker, R., Parkin, B., Parkin, C., Parkin, E., Parlanti, D., Parmar, C., Parodi, M., Parra Abaunza, K., Parra Baños, P. A., Parray, F., Parreira, P., Parri, P., Parrish, A., Parry, J., Parry, L., Parry-Smith, W., Parshad, R., Parsons, S., Parsons, T., Parulekar, R., Parveen, S., Parwaiz, H., Pascale, M. M., Pascarella, G., Ali, M. U., Pascua-Gómez, L. A., Pascual, Á, Pascual Arellano, M. P., Pascual Escudero, V., Pascual Miguelañez, I., Pascual Samaniego, M., Pascual-Cambero, P., Pasini, M., Pasquini, E., Passadore, M., Ali, N., Pastor, O., Pastor, T., Pastor Nieto, M. B., Pastor Zapata, A., Pata, F., Patabendige, M., Patachia, R., Patel, A., Patel, A. M. E., Ali, R., Patel, B., Patel, J., Patel, K., Patel, L., Patel, M., Patel, N., Patel, P., Ali, S., Patel, R., Patel, S., Patelis, N., Patell, M., Patena Forte, J., Paterson, A., Paterson, H., Pathak, M., Pathak, P., Pathak, S., Pathan, S., Pathmanaban, O., Pathmanathan, K., Patil, M., Patil, N., Patil, R., Patini, R., Patino-Jaramillo, N. G., Patkar, A., Patkar, P., Patkar, S., Patoulias, I., Patra, S., Patrizi, A., Patrone, R., Patzer, K., Abdelkhalek, M., Paucar Urbina, A. D. P., Paul, C., Paul, E., Paul, M., Paul, R., Paul, S., Paulino, H., Paulino, J., Paulo, M., Paulsen, L., Ali, W., Paunero Vazquez, P., Paunovic, A., Paunovic, I., Pavic Palac, P., Pavithran, A., Pavlov, M., Pavlov, P., Pavlovic, I., Pāvulāns, J., Pawar, A., Ali, Y., Pawar, N., Pawar, P., Pawar, S., Payá-Llorente, C., Payet, E., Pazmino-Canizares, J., Pb, B. K. P. B., Pcolkins, A., Pearce, A., Pearson, N., Ali Akbari, A., Pecchini, F., Peckham-Cooper, A., Pecoraro, A., Pecoraro, F., Pednekar, A., Pedraza Alonso, N. F., Pedraza Salazar, I. I., Pedrazzani, C., Pedreira Duprat Neto, J., Pedrero Escalas, M. F., Ali Al-Radhi, A. M., Pedrini Cruz, R., Pedro, J., Pedrosa, L., Pedroso Alvarenga, B. D., Pedroso de Lima, R., Pędziwiatr, M., Peerally, B. N., Peeriyah, S., Peev, I., Pehar, H., Ali Karar, A. A., Peiper, C., Peirce, C., Peiris, B., Pejkova, S., Pejovic, I., Pelegrina-Lopez, M. L., Pelet, S., Pellacani, A., Pellegrini, A., Pelletier, G., Ali Mohamed, M., Pelli, M., Pellicano', G. A., Pellini, R., Pellino, G., Pelloni, M., Peltrini, R., Pempe, C., Peña Balboa, L. G., Peña Gómez Portugal, E., Peña Ros, E., Ali Saad Salama, S., Peñarrocha, J., Pendyala, K. S., Penezić, L., Peng, E., Pengermä, P., Pennington, R., Penserga, E., Pepe, G., Peralta Ferreira, M., Peravali, R., Ali Shaikh, S., Percy, D., Perea Del Pozo, E., Perea Serna, A. C., Pereca, J., Pereda, A., Pereda, M., Pereira, A., Pereira, C., Pereira, F. C., Pereira, M., Aliaga-Sanchez, A., Pereira, R., Pereira-Neves, A., PereiraNuñez, D., Perepelitsa, O., Perera, E., Perera Sarri, R., Perets, M., Peretti, M., Perez, I., Perez, Y., Abdellah, F., Alias, A., Pérez, C., Pérez, K. D., Pérez Cajti, J. D., Perez Cerdeira, M., Pérez Costoya, C., Pérez de León Vázquez, M. P., Pérez Febles, M., Perez Fernandez, M. A., Perez Ferrer, A., Perez Gonzalez, M., Aliosin, O., Pérez González, M., Perez Granados, C., Pérez López, F., Pérez Meave, J. A., Pérez Palao, S., Perez Rivera, C. J., Pérez Romero, N., Pérez Rubio, Á, Pérez Santiago, L., Pérez Uribe, R. A., Alis, H., Perez Vidal, R., Perez Villena, J., Pérez-Bertólez, S., Perez-Chrzanowska, H., Pérez-Navarro, J. V., Pérez-Saborido, B., Pérez-Sánchez, L. E., Pérez-Tierra Ruiz, J. V., Pergolini, I., Perić, I., Aliwa, M., Perini, M., Perinotti, R., Peris, N., Perišić, G., Perivoliotis, K., Perkins, R., Peros, G., Perra, T., Perreas, K., Perricos, A., Aliyeva, G., Perrone, A. M., Perrone, F., Perrone, G., Perrot, O., Persad, A., Persiani, R., Pertile, D., Perumal Kanniappan, A., Pervaiz, A., Pesántez Peralta, M. A., Aliyeva, Z., Pesce, A. L., Pesce, V., Pesenti, G., Peshattiwar, V., Pesquera, L., Pessaux, P., Pesta, M., Peswani, A., Petagna, L., Peteja, M., Aliyu, M. S., Peters, L., Peters, P., Petersson, J., Petousis, S., Petrakis, N., Petrauskas, D., Petrenko, K., Petrillo, M., Petropoulos, K., Petrovic, B., Alizadeh, N., Petrovic, M., Petrusan, A., Petruț, B., Petruzzi, G., Petzold, A., Peyroteo, I., Pezeshki Modarres, M., Pezzuto, A. P., Pfingst Rojas, C., Pfister, K., Aljabali, A., Phadnis, A., Pham, H., Pham, T., Phan, D., Phang, I., Phanse, S. S., Philip, A., Philip, K., Philip, M., Phillip, A., Aljabri, M., Phillips, D., Phillips, E., Phillips, J., Phillips, R., Phung, D., Piachas, A., Picardo, A. L., Picariello, M., Picazo Pineda, E., A Azab, M., Abdelmajeed, A., Aljabri, N., Picazo Pineda, F., Picchetto, A., Picciariello, A., Piccioni, S. 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T., Moreno Sierra, J., Moreno Suarez, M., Moreno Y Suárez, T., Moreno-Gutierrez, A., Moret, C., Moretto, G., Moretto, S., Morezzi, D., Alemán, M., Morgan, C., Morgan, E., Morgan, K., Morgan, R., Morgan, S., Morhason-Bello, J., Mori, K., Moriarty, C., Morić, T., Morichau-Beauchant, T., Alemanno, G., Moriche Carretero, M., Moris, D., Morita, T., Moriyama, M., Morla, A. A., Morley, H. L., Morna, M. T., Moro-Valdezate, D., Morochovič, R., Morote, M., Alemu, B., Morović, D., Morris, B., Morris, D., Morris, R., Morrison, J., Morrison-Jones, V., Morsy, A., Morsy, M. S., Mortada, H., Alemu, M., Mortazavi, S. M. J., Mortiers, X., Mortimer, B., Mortini, P., Morton, A., Mosabha, M., Moslemi, M. K., Mosley, F., Mosneaga, R., Mosorin, M. A., Abdelgadir, A., Alen Villamayor, V., Mosos, M., Mosquera Paz, M. S., Moss, J. L., Mossaad, M., Mosshammer, V., Mostafa, A. M. H. A. M., Mostafa, B., Mostafa, M., Mostafa, M. E., Mosteiro-Cadaval, A., Alesmail, A., Mota, C., Motallebzadeh, R., Motas, N., Motasaddi Zarandy, M., Motoyasu, A., Motter, D., Motwani, K., Moug, S., Mougahed, M., Mouhandes, A. E., Alexakis, N., Moujtahid, H., Moukoko, D., Moura, M., Mourad, M., Mouriaux, F., Mourmouris, P., Mousa, M., Moussa, A., Moustafa, E., Moutinho, L., Alexander, D., Mouw, T., Moya-Angeler, J., Moyana Muguto, V., Moyano, P., Moyo, A., Moyo, G., Moyo, N., Mozafari, M., Mozel, M., Mpagi Katassi, L., Alexander, G., Mpirimbanyi, C., Mrad, B., Mrad, M. A., Mraiyan, M., Mshelbwala, P., Msherghi, A., Mtimkulu, W., Muallem-Kalmovich, L., Mubambe, M., Alexander, P., Mubarek, K., Mubarik, A., Mubaydeen, T., Mubezi, I., Mucilli, F., Muduly, D., Muehlbacher, I., Mueller, L. K., Muftah, H., Mufth, M., Alexander, T., Muganga, D., Mughal, A., Mughal, S., Mughal, Z. U., Mugisa, D., Mugla, W., Muguerza, J. M., Muguwu, A., Muhammad, A. B., Muhammad, R., Muhammad, S., Muhammad Daneji, S., Muheilan, M., Muhemi, R., Muhmmed, K., Muhssein, H., Muhtaroğlu, A., Muhtaseb, M., Alexandrou, A., Muirhead, W., Muiru, C., Mujtaba, S. N., Mukase, S., Mukezamfura, R., Mukherjee, P., Mukherjee, S., Mukhtar, I. A., Alexe, V., Mulas Fernández, C., Mulchandani, M., Mulder, W. W., Muleta, L., Muleta, M. B., Mulita, F., Mulla, H., Mulla, O., Muller, B., Müller, A., Abdelgalel, K., Alezabi, B., Müller, K., Müller, S., Müller, T., Mulliri, A., Mulugeta, E., Mulugeta, G., Mumtaz, K., Munanzvi, K., Munarriz, M., AlFakhri, A., Munawwar, F., Muneza, S., Mungazi, S., Muniandy, M., Munini, M., Munir, M. M., Munoz, H., Munoz Abraham, A. S., Muñoz Botero, N. A., Muñoz Camarena, J. M., Alfarah, M., Muñoz de Nova, J. L., Muñoz Fernández, M. E., Muñoz Lindez, I., Muñoz Rodríguez, J. M., Muñoz Sornosa, E., Muñoz Vives, J. M., Muñoz-Bellvis, L., Munro, W., Munshi, F., Muntaka, A. M., Alfaro, H., Muntean, G. 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N., Nagra, S., Nah, S. A., Nahal, E. A., Nahm, C., Algarni, M., Nahtomi Shick, O., Naieem, M., Naik, P., Nail, D., Naimy, G., Nair, A., Nair, A. K., Nair, D., Nair, G., Algarni, S., Nair, S., Nair, V. P., Naiya, H. I. I., Najafian Motahaver, N., Najera, R., Naji, N., Naji, O., Najjad, M. K. R., Najjar, M. S., Nakagawa, S., Alghamdi, A., Nakamura, Y., Nakanishi, R., Nakano, L., Nakanwagi, C., Nakas, A., Nakata, Y., Nakazawa, H., Nakirijja, T., Namikawa, T., Namrata, D., Abdelhafez, M., Namugenyi, C., Namutosi, E., Nana, G. R., Nanayakkara, A., Nankivell, P., Naoum, N., Napolitano, L., Nappi, F., Nappo, G., Naqi, S. A., Alghamdi, A. A., Naqui, Z., Naqvi, W., Naraen, A., Naranjo, S., Narasiman, V., Narasimhan, G., Narayan, S., Narayanan, V., Narayanasamy, K., Nardi, C., Naredla, P., Narendra, D., Narroway, H., Naseem, H., Naseem, M. Y., Naseer, M., Naseer, M. A., Nashed, E., Nashidengo, P. R., Nasir, A., Alghamdi, I., Nasir, M., Naskar, U., Nasreddin, M., Nasri, M. Z., Nassali, G., Nassanga, R., Nassar, A., Nassef, M. A., Alghamdi, R., Nasser, A., Nasser, N., Nasser, S., Nassif, M., Nassif, Y., Nassimu, M., Natal Álvarez, F., Nataraja, R., Nathan, M., Nathan, S. K., ALghamdi, S., Nathani, R., Nativ, H., Naumeri, F., Naunheim, M., Naureen, S., Nausheen, S., Navaratne, L., Navarrete-Peón, A., Navarro, A., Navarro, D., Alghamdi, S., Navarro, J. C., Navarro Casado, R., Navarro Martínez, S., Navarro-Alean, J., Navarro-Barrios, A., Navarro-Sánchez, A., Nawara, H., Nawawi, A., Nayak, P., Nayen, A., Alghazal, T., Nayyer, F., Naz, F., Nazal, M., Nazar, Z., Nazia, N., Nazimi, A. J., Nazir, S., Nazir, S. F., Nazir, U., Ncogoza, I., Alghazo, A., Ndabvonga, G., Ndatewapo, F., Ndayishyigikiye, M. D., Ndegbu, C., Ndizeye, O., Ndlovu, S., Ndong, A., Neagu, A., Neal, A., Neal, N., Alghuson, L., Neal-Smith, G., Neary, P., Negash, S., Negoi, I., Negreanu, L., Negrete Ocampo, J. R., Negussie, A., Nehe, A., Neidert, N., Collaborative, Covidsurg, Collaborative Dmitri Nepogodiev, Globalsurg, F Simoes, Joana F, Li, Elizabeth, Glasbey, Jame, Picciochi, Maria, K Kamarajah, Sivesh, Gujjuri, Rohan, Bhangu, Aneel, A, Maryam, A Azab, Mohammed, A Janjua, Dratif, A Zahran, Mohammed, A Abdelaziz, Areej, Luglio, Gaetano, Surgery, Medicine and Pharmacy academic/administration, Basic (bio-) Medical Sciences, Clinical sciences, Surgical clinical sciences, Faculty of Medicine and Pharmacy, Medical Oncology, Gastroenterology, Department of Surgery, HUS Abdominal Center, Chiantera, V, Pecoraro, F, COVIDSurg Collaborative, GlobalSurg Collaborative, Paediatric Surgery, Amsterdam Gastroenterology Endocrinology Metabolism, AGEM - Endocrinology, metabolism and nutrition, Graduate School, Amsterdam Reproduction & Development (AR&D), Tytgat Institute for Liver and Intestinal Research, Institut de Recherche sur les Maladies Virales et Hépatiques (IVH), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie (ICube), École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Université de Strasbourg (UNISTRA)-Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Les Hôpitaux Universitaires de Strasbourg (HUS)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Laura Alberici, Filippo Antonacci, Alessandro Arena, Angela Belvedere, Fabio Bernagozzi, Paolo Bernante, Pietro Bertoglio, Lorenzo Bianchi, Maria Bisulli, Barbara Bonfanti, Safia Boussedra, Jury Brandolini, Crescenzo Cacciapuoti, Stefano Cardelli, Riccardo Casadei, Matteo Cescon, Alessandro Cipolli, Riccardo Cipriani, Alfredo Conti, Luca Contu, Francesco Costa, Niccolo’ Daddi, Eugenia De Crescenzo, Pierandrea De Iaco, Alessandra De Palma, Massimo Del Gaudio, Anna Nunzia Della Gatta, Giampiero Dolci, Giulia Dondi, Matteo Droghetti, Sergio Nicola Forti Parri, Elena Garelli, Chiara Gelati, Giuliana Germinario, Federico A. Giorgini, Carlo Ingaldi, Elio Jovine, Kenji Kawamukai, Antonio Lanci Lanci, Raffaele Lombardi, Maria Elisa Lozano Miralles, Claudio Marchetti, Michele Masetti, Francesco Minni, Daniele Morezzi, Daniele Parlanti, Alice Pellegrini, Anna Myriam Perrone, Anna paola Pezzuto, Marco Pignatti, Gianluigi Pilu, Valentina Pinto, Gilberto Poggioli, Silvana Bernadetta Puglisi, Diego Raimondo, Matteo Ravaioli, Claudio Ricci, Sara Ricciardi, Francesco Ricotta, Roberta Rizzo, Angela Romano, Matteo Rottoli, Riccardo Schiavina, Renato Seracchioli, Matteo Serenari, Margherita Serra, Leonardo Solaini, Piergiorgio Solli, Gioia Sorbi, Mario Taffurelli, Marta Tanzanu, Achille Tarsitano, Marco Tesei, Gabriele Vago, Tommaso Violante, Simone Zanotti, Tommaso Frisoni, pignatti marco, ERSÖZ, CEVPER, GlobalSurg Collaborative, COVIDSurg Collaborative, Nepogodiev, Dmitri, Simoes, Joana F. F., Glasbey, James C., Alser, Osaid, Boccalatte, Luis A., Calvache, Jose A., Duran, Irani, Elhadi, Muhammed, Elmujtaba, Mohammed, Emile, Sameh, Harrison, Ewen M., Hutchinson, Peter, Allen Ingabire, J. C., Isik, Arda, Kamarajah, Sivesh K., Karandikar, Sharad, Kauppila, Joonas H., Kembuan, Gabriele, Lederhuber, Han, Löffler, Markus W., Mann, Harvinder, Marson, Ella J., Mclean, Kenneth A., Munyaneza, Emmanuel, Norman, Lisa, Omar, Omar M., Pius, Riinu, Pockney, Peter, Rutegård, Martin, Stewart, Grant D., Taylor, Elliott H., Venn, Mary L., Aizza, Giada, Bellio, Gabriele, Bogoni, Selene, Bortul, Marina, Casagranda, Biagio, Cortinovis, Sara, de Manzini, Nicolo', Drigo, Davide, Germani, Paola, Mastronardi, Manuela, Paiano, Lucia, Palmisano, Silvia, Nepogodiev, D, Bhangu, A, Gallo, G, Picciariello, P, Abushanab, M, Fruscio, R, Ornaghi, S, Iovino, C, Rossi, S, and Simonelli, F
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Male ,COVID-19 Vaccine ,safe surgery ,vaccination modelling ,COVID-19 ,Vascular damage Radboud Institute for Health Sciences [Radboudumc 16] ,MULTICENTER ,Comorbidity ,030230 surgery ,0302 clinical medicine ,phase 3 clinical trial (topic) ,Case fatality rate ,Prospective Studies ,SARS-CoV-2 , Vaccination , Safe surgery ,COVID-19/epidemiology ,SARS-CoV-2 ,vaccination ,education.field_of_study ,case fatality rate ,Vaccination ,Adolescent ,Adult ,Aged ,COVID-19 Vaccines ,Elective Surgical Procedures ,Female ,Humans ,Middle Aged ,Postoperative Complications ,Preoperative Period ,Young Adult ,health care policy ,030220 oncology & carcinogenesis ,cancer ,outcome ,mortality ,infection ,modelling ,Cohort study ,prospective study ,Human ,medicine.medical_specialty ,Article ,03 medical and health sciences ,SARS-CoV-2, vaccination ,SDG 3 - Good Health and Well-being ,COVID-19 Vaccines/pharmacology ,Vaccination/methods ,Elective surgery ,education ,Science & Technology ,Elective Surgical Procedure ,adult ,aged ,cancer grading ,cancer surgery ,computer assisted tomography ,elective surgery ,female ,follow up ,human ,incidence ,infection rate ,infection risk ,major clinical study ,male ,middle aged ,outcome assessment ,preoperative care ,sensitivity analysis ,seroprevalence ,Severe acute respiratory syndrome coronavirus 2 ,young adult ,surgery ,Cura preoperatòria ,Prospective Studie ,Surgery ,Human medicine ,Postoperative Complication ,610 Medizin und Gesundheit ,AcademicSubjects/MED00910 ,Settore MED/18 - CHIRURGIA GENERALE ,Settore MED/29 - CHIRURGIA MAXILLOFACCIALE ,ESTUDOS PROSPECTIVOS ,Vacunació ,Prospective cohort study ,Incidence (epidemiology) ,covid ,Elective Surgical Procedures/methods ,COVID, vaccination ,Original Article ,AcademicSubjects/MED00010 ,Life Sciences & Biomedicine ,international prospective cohort study ,Postoperative Complications/prevention & control ,Population ,SARS-CoV-2/immunology ,NO ,medicine ,ddc:610 ,LS7_4 ,business.industry ,Number needed to vaccinate ,Preoperative care ,3126 Surgery, anesthesiology, intensive care, radiology ,Settore MED/18 ,Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10] ,Emergency medicine ,business ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
Background Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling. Methods The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an international cohort study (surgical patients), and community SARS-CoV-2 incidence and case fatality data (general population). NNV estimates were stratified by age (18–49, 50–69, 70 or more years) and type of surgery. Best- and worst-case scenarios were used to describe uncertainty. Results NNVs were more favourable in surgical patients than the general population. The most favourable NNVs were in patients aged 70 years or more needing cancer surgery (351; best case 196, worst case 816) or non-cancer surgery (733; best case 407, worst case 1664). Both exceeded the NNV in the general population (1840; best case 1196, worst case 3066). NNVs for surgical patients remained favourable at a range of SARS-CoV-2 incidence rates in sensitivity analysis modelling. Globally, prioritizing preoperative vaccination of patients needing elective surgery ahead of the general population could prevent an additional 58 687 (best case 115 007, worst case 20 177) COVID-19-related deaths in 1 year. Conclusion As global roll out of SARS-CoV-2 vaccination proceeds, patients needing elective surgery should be prioritized ahead of the general population., The aim of this study was to inform vaccination prioritization by modelling the impact of vaccination on elective inpatient surgery. The study found that patients aged at least 70 years needing elective surgery should be prioritized alongside other high-risk groups during early vaccination programmes. Once vaccines are rolled out to younger populations, prioritizing surgical patients is advantageous.
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- 2021
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4. Three-dimensional primary reconstruction of anterior mouth floor and ventral tongue using the ‘trilobed’ buccinator myomucosal island flap
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Massarelli, O., Gobbi, R., Raho, M.T., and Tullio, A.
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- 2008
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5. COMPARTMENT SYNDROME AT THE FIBULA FLAPʼS DONOR SITE AND SALVAGE BY ANEROLATERAL THIGH CHIMERIC FLAP
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Rubino, C., Faenza, M., Muzzeddu, G. P., Massarelli, O., Tullio, A., and Farace, F.
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- 2012
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6. Fibula free flap pedicle ossification: Experience of two centres and a review of the literature
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Baserga, C, Massarelli, O, Bolzoni, A, Rossi, D, Beltramini, G, Baj, A, Giannì, A, Bolzoni, AR, Rossi, DS, Beltramini, GA, Giannì, AB, Baserga, C, Massarelli, O, Bolzoni, A, Rossi, D, Beltramini, G, Baj, A, Giannì, A, Bolzoni, AR, Rossi, DS, Beltramini, GA, and Giannì, AB
- Abstract
Purpose: The osteogenic potential of vascularized periosteum has been described in a few cases in the literature, and many different factors have been pointed out as plausible. Our aim was to review the literature in order to give a complete overview of this topic and to report on our clinical experience. Patients & Methods: Our experience includes three patients who underwent maxillectomy and FFF reconstruction. A progressive reduction in mouth opening was noticed in the months after surgery, and CT scans showed calcified tissue around the pedicle. Surgical revisions were performed. No recurrences were noticed. A full systematic literature review was conducted, including studies published on or before September 2016. Results: Clinically, free flap pedicle ossification is presented as trismus, hard swelling, and severe pain during movements, although the diagnosis is scarce and often fortuitous. From January 2010 to January 2016 we performed 68 FFF reconstructions, and the incidence of FFF pedicle ossification in our experience was 4.4%. Conclusion: Ossification of FFF pedicle is uncommon, but when it occurs, it has dramatic clinical consequences. Follow-up CT scan can be useful in diagnosis. In our experience, surgery should be performed only when the patient is symptomatic.
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- 2018
7. Islanded facial artery musculomucosal flap for tongue reconstruction
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Massarelli, O., primary, Vaira, L.A., additional, and De Riu, G., additional
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- 2017
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8. UPPER JAW IMPLANT RESTORATION ON SIX IMPLANTS WITH FLAPLESS GUIDED TEMPLATE SURGERY AND IMMEDIATE LOADINGS: 5 YEARS RESULTS OF PROSPECTIVE CASE SERIES.
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MELONI, S. M., SPANO, G., CERUSO, F. M., GARGARI, M., LUMBAU, A., BALDONI, E., MASSARELLI, O., PISANO, M., and TALLARICO, M.
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IMMEDIATE loading (Dentistry) ,MAXILLA ,DENTURES ,COMPUTER-assisted surgery ,SURGERY ,COMPLICATIONS of prosthesis - Abstract
Background. To evaluate the clinical and radiographic outcomes of upper jaws fixed cross-arches prosthesis on 6 implants installed with 3D software planning, flapless guided surgery, and immediate loading. Methods. Healthy patients aged 18 years or older at the time of implant placement, in need to be re-stored with an immediately loaded implant-supported screw-retained cross-arch fixed dental prosthesis in the maxilla were included in the present study and treated using computer-assisted template-guided surgery. In order to be immediately loaded implant sites were prepared and an insertion torque ranging between 35-45 Ncm was applied. A prefabricated screw-retained temporary prosthesis was delivered the day of the surgery. The evaluated outcomes were: implant cumulative survival rate (CSR), prosthe-sis survival, any technical and biologic complications, and peri-implant marginal bone level changes, probing pocket depth (PPD), and bleeding on probing (BOP). Results. Twenty-two patients (16 females and 6 males) with a mean age of 63.4 years received 132 im-plants to support 22 cross-arch screw-retained fixed dental prostheses. At the end of the study, no pa-tients dropped out. Three implants failed in 3 patients resulting in a CSR of 97.77%. No final prosthe-sis failed resulting in a CSR of 100%. No major biological or prosthesis complications were recorded. After an initial mean marginal bone loss of 1.10±0.38 mm, (95% CI 0.95 to 1.25 mm), at 12 months follow-up, slightly marginal bone loss was reported with time, resulting in a mean marginal bone loss of 1.58 ±0.41 mm, (95% CI 1.41 to 1.75 mm), at the 5-year follow-up. At 60 months follow-up mean PPD value was 2.44±0.49 mm, (95% CI 2.24 to 2.64 mm), mean BOP value was 1.34±0.87, (95% CI 0.98 to 1.70 mm). Conclusion. Within the limitations of this study it can be concluded that computer guided surgery and immediate loading on 6 implants seem to represent a viable option for the immediate fix rehabilitations of completely edentulous upper jaws. [ABSTRACT FROM AUTHOR]
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- 2019
9. Compartment syndrome at the fibula flap's donor site and salvage by anerolateral thigh chimeric flap
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Rubino, Corrado, Faenza, M., Muzzeddu, G. P., Massarelli, O., Tullio, A., Farace, F., Rubino, C., Faenza, M., Muzzeddu, G. P., Massarelli, O., Tullio, A., and Farace, F.
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Male ,Middle Aged ,Limb Salvage ,Compartment Syndromes ,Free Tissue Flaps ,Fibula ,Humans ,Postoperative Complications ,Reconstructive Surgical Procedures ,Thigh ,Surgery ,Compartment Syndrome ,Reconstructive Surgical Procedure ,Postoperative Complication ,Free Tissue Flap ,Human - Published
- 2012
10. Neck dissection in squamous-cell carcinoma of the maxillary gingiva, alveolus, and hard palate. A multicentre Italian study of 65 cases
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Beltramini, Ga, Baj, A, Massarelli, O, Valentini, V, Tullio, Antonio, Sesenna, E, and Gianni, Ab
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- 2013
11. Computer-Aided Implant Surgery in Free Flaps Reconstructed Patients, One Year Follow-Up Results of A Prospective Randomized Clinical Study
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Meloni, S.M., primary, De Riu, G., additional, Pisano, M., additional, Massarelli, O., additional, and Tullio, A., additional
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- 2011
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12. O.213 Submental flap in orofacial reconstruction
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Alì-Yussef, D., primary, Massarelli, O., additional, Baj, A., additional, Gobbi, R., additional, Raho, M.T., additional, Tullio, A., additional, and Gianni, A.B., additional
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- 2008
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13. O.218 The cheek: donor site with many reconstructive alternatives
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Massarelli, O., primary, Baj, A., additional, Ali-Youssef, D., additional, Gobbi, R., additional, Raho, M.T., additional, Giannì, A.B., additional, and Tullio, E.A., additional
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- 2008
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14. O.017 Pretrichial incision for upper third facial fractures
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Tullio, A., primary, Massarelli, O., additional, Gobbi, R., additional, and Raho, M.T., additional
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- 2008
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15. O79 The effect of tumour thickness on nodal upstaging by sentinel node biopsy in head and neck squamous cell cancer
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Alkureishi, L., primary, Ross, G., additional, Shoaib, T., additional, Thompson, R., additional, Camilleri, I., additional, Soutar, D., additional, Robertson, A.G., additional, Sorensen, J., additional, Thomsen, J., additional, Grupe, P., additional, Alvarez, J., additional, Barbier, L., additional, SantaMaria, J., additional, Poli, T., additional, Massarelli, O., additional, Sesenna, E., additional, Kovacs, A., additional, Grunwald, F., additional, Barzan, L., additional, Sulfaro, S., additional, and Alberti, F., additional
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- 2007
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16. O78 Sentinel node biopsy as a staging tool in early head and neck squamous cell cancer – long term follow-up of a multicentre trial
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Alkureishi, L., primary, Ross, G., additional, Shoaib, T., additional, Thompson, R., additional, Camilleri, I., additional, Soutar, D., additional, Robertson, A.G., additional, Sorensen, J., additional, Thomsen, J., additional, Grupe, P., additional, Alvarez, J., additional, Barbier, L., additional, SantaMaria, J., additional, Poli, T., additional, Massarelli, O., additional, Sesenna, E., additional, Kovacs, A., additional, Grunwald, F., additional, Barzan, L., additional, Sulfaro, S., additional, and Alberti, F., additional
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- 2007
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17. The folded tunnelized-facial artery myomucosal island flap: a new technique for total soft palate reconstruction.
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Massarelli O, Gobbi R, Soma D, and Tullio A
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- 2013
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18. Is neck dissection needed in squamous-cell carcinoma of the maxillary gingiva, alveolus, and hard palate? A multicentre Italian study of 65 cases and literature review.
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Beltramini GA, Massarelli O, Demarchi M, Copelli C, Cassoni A, Valentini V, Tullio A, Giannì AB, Sesenna E, and Baj A
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The occurrence of occult cervical metastases due to squamous-cell carcinoma of the hard palate and maxillary alveolar ridge has not been studied systematically. We have observed that many patients return with a delayed cervical metastasis following resection of a primary cancer at these sites. Some of these patients have died as a result of a regional or distant metastasis, despite control of the primary cancer. The literature contains few recommendations to guide the treatment of maxillary squamous-cell carcinoma; prospective studies are difficult due to the rarity of such tumours. The aim of this study is to define the incidence of cervical metastasis and to investigate whether elective neck dissection is justified. We present a retrospective multicentre study of 65 patients with squamous-cell carcinomas of the maxillary alveolar ridge and hard palate and review of the existing literature. The overall incidence of cervical metastases was 21%. We evaluated the significance of primary-site tumours as indicator of regional disease. The maxillary squamous-cell carcinoma cases in our multicentre study and in the literature review exhibited aggressive regional metastatic behaviour, comparable with that of carcinomas of the tongue, mouth floor, and mandibular gingiva. Based on our findings, we recommend selective neck dissection in clinically negative necks as a primary management strategy for patients with maxillary squamous-cell carcinomas involving the palate, maxillary gingiva, or maxillary alveolus. [ABSTRACT FROM AUTHOR]
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- 2012
19. Role of intra-operative sentinel lymph node biopsy in oral cavity and oropharynx squamous cell carcinoma: preliminary data
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Poli, T., Massarelli, O., Bianchi, B., Ferrari, S., Domenico CORRADI, Raise, G., and Sesenna, E.
20. Neck dissection with harmonic instruments and electrocautery: a prospective comparative study
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Luigi Angelo Vaira, Gabriele Vacca, Giovanna Deiana, Enrica Ligas, Pasquale Piombino, Bruno Carlo Brevi, Giacomo De Riu, Olindo Massarelli, Vaira, L. A., De Riu, G., Ligas, E., Deiana, G., Vacca, G., Massarelli, O., Piombino, P., and Brevi, B. C.
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medicine.medical_specialty ,Leak ,medicine.medical_treatment ,Operative Time ,Harmonic scalpel ,Surgical Instrument ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Tracheotomy ,Randomized controlled trial ,law ,Electrocoagulation ,medicine ,Humans ,Prospective Studies ,030223 otorhinolaryngology ,Ligature ,Harmonic blade ,business.industry ,Lymph duct ,Neck dissection ,030206 dentistry ,Electrocautery ,Surgical Instruments ,Surgery ,Prospective Studie ,Otorhinolaryngology ,Oral and maxillofacial surgery ,Neck Dissection ,Oral Surgery ,business ,Surgical hemostasi ,Human - Abstract
Background: Harmonic instruments are becoming popular in head and neck surgeries. In this prospective, randomized study, the efficacy of the harmonic instruments and electrosurgical technique is compared. Materials and methods: A total of 48 patients undergoing unilateral neck dissection were divided into two groups. In one group, surgery was performed using conventional hemostatic instruments while in the other, only harmonic instruments were used. The two techniques were then compared with regard to intra- and post-operative blood loss, complications in operating time, drain, tracheotomy and nasogastric tube duration, and post-operative hospital stay. Results: Differences in operative time (P = 0.647), total suction drainage (P = 0.362) and time that drains (P = 0.404), nasogastric tube (P = 0.378), and tracheotomy (P = 0.052) were kept in place and proved not significant. The average blood loss during surgery was significantly greater in the CH group (P = 0.003) as the number of hemoclips and resorbable ligature used (P = 0.002). Conclusions: In contrast to what has been reported up to now, our study did not reveal a net advantage in the use of harmonic instruments with respect to classical instruments in terms of surgical outcome. On the contrary, harmonic tools had a higher complication rate (i.e., salivary fistula and lymphatic leak) probably due to the decreased ability of this instruments to permanently close glandular structures and lymphatic ducts. In these cases, a closure technique such as electrocautery or classic knot-tying should be used.
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- 2020
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21. Accuracy of Fibula Reconstruction Using Patient-Specific Cad/Cam Plates: A Multicenter Study on 47 Patients
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Emanuele Zavattero, Manlio Gessaroli, A. Bolzoni, Gian Paolo Tartaro, Claudia Borbon, Stefano Valsecchi, Chiara Copelli, Alessandro Baj, Luigi Califano, Marco Sant'Agata, Valentino Valentini, Olindo Massarelli, Giovanni Orabona Dell’Aversana, Andrea Ferri, Guglielmo Ramieri, Marco Della Monaca, Andrea Varazzani, Giada Anna Beltramini, Roberto Cocchi, Zavattero, Emanuele, Bolzoni, Alessandro, Dell'Aversana, Giovanni, Santagata, Mario, Massarelli, Olindo, Ferri, Andrea, Della Monaca, Marco, Copelli, Chiara, Gessaroli, Manlio, Valsecchi, Stefano, Borbon, Claudia, Beltramini, Giada Anna, Ramieri, Guglielmo, Valentini, Valentino, Tartaro, Gian Paolo, Cocchi, Roberto, Varazzani, Andrea, Califano, Luigi, Baj, Alessandro, Zavattero, E., Bolzoni, A., Dell'Aversana, G., Santagata, M., Massarelli, O., Ferri, A., Della Monaca, M., Copelli, C., Gessaroli, M., Valsecchi, S., Borbon, C., Beltramini, G. A., Ramieri, G., Valentini, V., Tartaro, G. P., Cocchi, R., Varazzani, A., Califano, L., and Baj, A.
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Adult ,Male ,Patient-Specific Modeling ,medicine.medical_specialty ,CAD ,Surgical planning ,Free Tissue Flaps ,CAD/CAM ,Patient Care Planning ,03 medical and health sciences ,accuracy of reconstruction ,fibula flap ,mandibular reconstruction ,reconstruction surgery ,0302 clinical medicine ,Imaging, Three-Dimensional ,Medicine ,Humans ,Prospective Studies ,Mandibular reconstruction ,Fibula ,Prospective cohort study ,business.industry ,030206 dentistry ,Evidence-based medicine ,Patient specific ,Middle Aged ,Surgery ,Otorhinolaryngology ,Multicenter study ,Surgery, Computer-Assisted ,030220 oncology & carcinogenesis ,Computer-Aided Design ,Female ,Anatomic Landmarks ,Mandibular Reconstruction ,business - Abstract
Objectives: This prospective study evaluated the accuracy of mandibular reconstruction using free fibular flaps (by comparing virtual plans to the three-dimensional postoperative results), and the extent of bone-to-bone contact after computer-assisted surgery. Methods: We included 65 patients who underwent partial-continuity mandibular resections from February 2013 to January 2017, and evaluated virtual planning, surgical techniques, and accuracy. Results: Forty-seven patients were analysed. A total of 112 fibular segments received 54 implants. We measured 227 distances between landmarks to assess the accuracy of reconstruction. Postoperative reconstruction accuracy ranged from 0.5 to 3 mm. Conclusion: Virtual surgical planning very accurately translated simulation into reality, particularly in patients requiring large, complex mandibular reconstructions using multiple fibular segments. Level of evidence: 4 Laryngoscope, 131:E2169–E2175, 2021.
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- 2020
22. Reconstruction of full-thickness cheek defect with chimeric facial artery free flap: A case report
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Giacomo De Riu, Giovanni Dell'Aversana Orabona, Luigi Angelo Vaira, Olindo Massarelli, Roberta Gobbi, Massarelli, O, Vaira, L, Gobbi, R, Dell'aversana Orabona, G, and De Riu, G
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Male ,medicine.medical_specialty ,GUNSHOT INJURY ,Facial artery ,Free flap ,030230 surgery ,Free Tissue Flaps ,No donors ,03 medical and health sciences ,0302 clinical medicine ,medicine.artery ,medicine ,Humans ,Paddle ,Facial Injuries ,business.industry ,Middle Aged ,Plastic Surgery Procedures ,Cheek ,Surgery ,stomatognathic diseases ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Wounds, Gunshot ,Full thickness ,business ,Through and through - Abstract
Full-thickness cheek defects represent a difficult challenge for reconstructive surgeons. Multiple techniques have been described, including local, regional, and free flaps. In this report, the reconstruction of a through and through left cheek defect, resulting from a self-inflicted gunshot injury, with a chimeric facial artery free flap is presented. The patient underwent reconstruction with a chimeric full-thickness facial artery free flap, with 9 × 3 cm diameter skin paddle and a 6 × 5 cm myomucosal paddle, was harvested on the contralateral cheek with a 7-cm length of facial pedicle. The flap was transferred via a microsurgical technique and an end-to-end microsurgical anastomosis was performed between the donor and the contralateral facial vessels. The flap was transplanted successfully and there were no donor or recipient site complications with a satisfactory esthetic result 5 years after surgery. This technique may be a good reconstructive option for medium size, full-thickness, cheek defects allowing a "like with like" reconstruction with minimal donor-site morbidity.
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- 2017
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23. Rational and simplified nomenclature for buccinator myomucosal flaps
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Giacomo De Riu, Andrea Biglio, Pasquale Piombino, Luigi Angelo Vaira, Roberta Gobbi, Olindo Massarelli, Massarelli, O., Vaira, L. A., Biglio, A., Gobbi, R., Piombino, P., De Riu, G., Massarelli, Olindo, Vaira, Luigi Angelo, Biglio, Andrea, Gobbi, Roberta, Piombino, Pasquale, and De Riu, Giacomo
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Buccinator flap ,medicine.medical_specialty ,FAMMIF ,Oropharynx ,Musculomucosal flap ,Oral cavity ,Surgical Flaps ,Cheek flap ,03 medical and health sciences ,0302 clinical medicine ,Terminology as Topic ,FAMM ,Humans ,Medicine ,Mouth mucosa ,Nomenclature ,Confusion ,business.industry ,Otorhinolaryngology2734 Pathology and Forensic Medicine ,Mouth Mucosa ,030206 dentistry ,Buccinator ,eye diseases ,Surgery ,Surgical Flap ,Otorhinolaryngology ,Myomucosal flap ,030220 oncology & carcinogenesis ,Oral Surgery ,medicine.symptom ,business ,Human - Abstract
Background: Reconstruction of moderate-sized mucosal defects of the oral cavity or oropharynx represents a surgical challenge. Buccinator myomucosal flaps seem to provide âideal reconstructionâ of oral/oropharyngeal defects because they carry a thin, mobile, well-vascularized, and sensitive tissue, like that excised or lost. Nevertheless, these flaps are not immediately popular because of confusion surrounding the complex terminology used to name them. Methods: After a retrospective study on our experience and a literature review, the authors propose a new rational and simplified nomenclature for the classification of buccinator myomucosal flaps, which clarifies the source vessel, the composition of the flap, and the type of transfer. Results: According to this nomenclature, six types of buccinator myomucosal flaps are described. Conclusions: This proposed nomenclature may bring a consensus on the classification of buccinator myomucosal flaps and can help their spread.
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- 2017
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24. Soft palate functional reconstruction with buccinator myomucosal island flaps
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G. Dell'Aversana Orabona, Luigi Angelo Vaira, Roberta Gobbi, Andrea Biglio, G De Riu, Olindo Massarelli, Massarelli, O., Vaira, L. A., Gobbi, Lucia, Biglio, A., Dell'aversana Orabona, G., and DE RIU, Giancarlo
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Male ,medicine.medical_specialty ,Oral Surgical Procedures ,buccal artery myomucosal island flap ,Island Flaps ,Transplant Donor Site ,Surgical Flaps ,03 medical and health sciences ,0302 clinical medicine ,Postoperative Complications ,Quality of life ,Swallowing ,FAMM ,medicine ,Humans ,030223 otorhinolaryngology ,oropharyngeal reconstruction ,Aged ,Pain Measurement ,Retrospective Studies ,buccinator myomucosal flap ,Soft palate ,business.industry ,Otorhinolaryngology2734 Pathology and Forensic Medicine ,Mouth Mucosa ,t-FAMMIF ,Retrospective cohort study ,030206 dentistry ,BAMMIF ,Middle Aged ,Plastic Surgery Procedures ,Buccinator ,facial artery myomucosal island flap ,Surgery ,medicine.anatomical_structure ,Treatment Outcome ,Otorhinolaryngology ,Head and Neck Neoplasms ,Quality of Life ,cheek myomucosal flap ,Female ,soft palate reconstruction ,Palate, Soft ,Oral Surgery ,business - Abstract
Oropharyngeal reconstruction after ablative surgery is a challenge. The results of a retrospective study of 17 patients who underwent total or sub-total soft palate reconstruction with a buccinator myomucosal island flap, between 2008 and 2016, are reported herein. An analysis of flap type and size, harvesting time, and postoperative complications was performed. Patients underwent standardized tests to assess the recovery of sensitivity, deglutition, quality of life (QoL), and donor site morbidity, at >6 months after surgery or the end of adjuvant therapy, if performed. All flaps were transposed successfully. Only minor donor and recipient site complications occurred. The sensitivity assessment showed that touch, two-point discrimination, and pain sensations were recovered in all patients. Significant differences between the flap and native mucosa were reported for tactile (P=0.004), pain (P=0.001), and two-point discrimination (P=0.001) thresholds. The average deglutition score reported was 6.1/7, with only minimal complaints regarding deglutition. The QoL assessment showed high physical (24.6/28), social (25/28), emotional (19.1/24), and functional (24.6/28) scores. No major donor site complications were noted in any patient; the average donor site morbidity score was 8.1/9. Buccinator myomucosal island flaps represent a valuable functional oropharyngeal option for reconstruction, requiring a short operating time and presenting a low donor site morbidity rate.
- Published
- 2018
25. Fibula free flap pedicle ossification: Experience of two centres and a review of the literature
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Giada Anna Beltramini, C. Baserga, Alessandro Baj, D. Rossi, Olindo Massarelli, A. Bolzoni, Aldo Bruno Giannì, Baserga, C, Massarelli, O, Bolzoni, A, Rossi, D, Beltramini, G, Baj, A, and Giannì, A
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Adult ,Male ,Reoperation ,medicine.medical_specialty ,medicine.medical_treatment ,Fibula free flap ,Free flap ,Trismus ,Free Tissue Flaps ,03 medical and health sciences ,0302 clinical medicine ,Postoperative Complications ,Radiography, Panoramic ,medicine ,Severe pain ,Humans ,Fibula ,030223 otorhinolaryngology ,Reduction (orthopedic surgery) ,Maxillary Neoplasms ,Periosteum ,Ossification ,business.industry ,Ossification, Heterotopic ,Middle Aged ,Plastic Surgery Procedures ,Surgery ,Free flap pedicle ossification ,medicine.anatomical_structure ,Systematic review ,Otorhinolaryngology ,030220 oncology & carcinogenesis ,Pedicle ossification ,Female ,Oral Surgery ,medicine.symptom ,business ,Pedicle ossification, Free flap pedicle ossification, Fibula free flap ,Tomography, X-Ray Computed - Abstract
Purpose The osteogenic potential of vascularized periosteum has been described in a few cases in the literature, and many different factors have been pointed out as plausible. Our aim was to review the literature in order to give a complete overview of this topic and to report on our clinical experience. Patients & Methods Our experience includes three patients who underwent maxillectomy and FFF reconstruction. A progressive reduction in mouth opening was noticed in the months after surgery, and CT scans showed calcified tissue around the pedicle. Surgical revisions were performed. No recurrences were noticed. A full systematic literature review was conducted, including studies published on or before September 2016. Results Clinically, free flap pedicle ossification is presented as trismus, hard swelling, and severe pain during movements, although the diagnosis is scarce and often fortuitous. From January 2010 to January 2016 we performed 68 FFF reconstructions, and the incidence of FFF pedicle ossification in our experience was 4.4%. Conclusion Ossification of FFF pedicle is uncommon, but when it occurs, it has dramatic clinical consequences. Follow-up CT scan can be useful in diagnosis. In our experience, surgery should be performed only when the patient is symptomatic.
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- 2017
26. New Classification System and Defect-Oriented Algorithm for Functional Soft-Palate Reconstruction with Buccinator Myomucosal Flaps.
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Massarelli O, Catarzi L, Gabriele G, Cascino F, Frosolini A, and Gennaro P
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Background/Objectives : Currently, there is a lack of a comprehensive classification system for soft-palate defects that provides synthetic information to guide functional reconstructive treatment. Our awareness, shaped by extensive experience, of the superiority of myomucosal flaps to fasciocutaneous flaps in functional palate reconstruction has driven us to introduce a new defect-based classification system and propose a new algorithm for reconstructing soft-palate defects using buccinator myomucosal flaps. Methods : Soft-palate defects were classified into five classes. A reconstruction algorithm employing buccinator myomucosal flaps-including axial, island, and tunnelized flaps along with their variants as described in previous studies-was utilized. Clinical records, including tumor stage, location, defect size, and details of the myomucosal flap used, were documented. Postoperative speech intelligibility, swallowing, and quality of life (QoL) were evaluated. Donor-site morbidity and complications were also assessed. Spearman's rank correlation was employed to assess relationships between clinical parameters and functional outcomes. Results : Twenty-two patients who had undergone soft-palate resection and subsequent reconstruction were reviewed. Favorable recovery of swallowing and speech was reported in all cases, with a median deglutition score of 6.04 ± 0.85 and no severe velopharyngeal insufficiency observed (speech score: 0.36 ± 0.58). Quality of life assessments indicated satisfactory recovery across physical, social, emotional, and functional parameters. Donor-site morbidity was low (average score: 8.3), with only minor complications observed. Tumor stage showed a significant correlation with speech score (r = 0.44, p = 0.04). Conclusions : The proposed classification introduces a comprehensive, simple, and user-friendly categorization of soft-palate defects, accompanied by a myomucosal reconstructive algorithm designed to guide surgeons through the reconstructive process, aiming to provide optimal functional reconstruction. The study's small sample size and monocentric design may have limited the detection of meaningful correlations, highlighting the need for larger, multicentric studies with objective methods to validate findings.
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- 2024
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27. Exoscope and Supermicrosurgery: Pros and Cons of 3D Innovation in Lymphatic Surgery.
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Frosolini A, Benedetti S, Catarzi L, Massarelli O, Gennaro P, and Gabriele G
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Background: The surgical treatment of lymphedema has seen advancements in recent years, with supramicrosurgical lymphaticovenular anastomosis (sLVA) gaining global acceptance. The integration of 3D exoscopes into microsurgery offers potential ergonomic and educational benefits. However, systematic evaluation of their efficacy in sLVA remains limited. Methods: A retrospective cross-sectional study was conducted comparing the use of 3D exoscopes to conventional operating microscopes (OM) in sLVA surgeries. Patient data from January 2019 to January 2024 were reviewed, with demographic, clinical, and surgical outcome variables analyzed. Ergonomic assessments were performed using Rapid Entire Body Assessment (REBA) and Rapid Upper Limb Assessment (RULA), while surgeon satisfaction was evaluated through the Microsurgical Intraoperative Satisfaction and Comfort questionnaire (MISCq). Results: An analysis of 25 patients (OM group: n = 14; exoscope group: n = 11) revealed no significant differences in age, sex, etiology, or surgical site between the two groups. Surgical time, number of incisions, and number of anastomoses showed nonsignificant variations between the OM and exoscope groups. Ergonomic assessments indicated potential benefits with exoscope use, particularly for the assistant surgeon. Survey results demonstrated comparable levels of surgeon satisfaction with both instruments, with no significant differences in image quality, contrast, illumination, magnification, visual field, ergonomic maintenance, or stereoscopic orientation. Conclusions: The study suggests that 3D exoscopes are a valuable tool for sLVA supermicrosurgery, offering comparable outcomes to traditional microscopes with potential ergonomic advantages. Their integration into microsurgical practice may contribute to improved surgical comfort and team performance. Further research is warranted to confirm these findings and explore additional factors such as cost-effectiveness and long-term patient outcomes.
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- 2024
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28. Combination of Supramicrosurgical Lymphatico-Venular Anastomosis (sLVA) and Lymph-Sparing Liposuction in Treating Cancer-Related Lymphedema: Rationale for a Regional One-Stage Approach.
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Gabriele G, Nigri A, Chisci G, Massarelli O, Cascino F, Komorowska-Timek E, Kazuki K, Hara H, Mihara M, and Gennaro P
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Objective: Cancer-related lymphedema represents a potential complication of cancer treatment. The aim of this study is to evaluate the effectiveness of the combination of lymphatico-venular anastomosis and liposuction in the treatment of secondary lymphedema. Methods: We present a retrospective analysis of patients affected by cancer-related unilateral limb lymphedema. Inclusion criteria included previous neoplastic pathology with the consequent development of unilateral limb lymphedema, while the exclusion criteria included the presence of comorbidities and the persistence of cancer, as well as previous lymphatic surgery. The outcomes to be included were a reduction in the limb volume and lymphangitis rate, and an improvement in the quality of life. Patients' data were assessed before surgery and 1 year after surgery. Perioperative management included clinical and ultrasonographical evaluations. Under local anesthesia, lymphatico-venular anastomosis with the supramicrosurgical technique and the liposuction of the affected limb was performed in the same surgical session. Results: A total of 24 patients were enrolled in the study. One year after the surgery, an average volume reduction of 37.9% was registered ( p = 0.0000000596). The lymphangitis rate decreased after surgery from 4.67 to 0.95 per year ( p = 0.000007899). The quality-of-life score improved from 68.7 to 16 according to the LLIS scale. Conclusions: The combination of LVA and liposuction represents a valid strategy for treating cancer-related lymphedema, ensuring stable results over time. In addition, it can be performed under local anesthesia, resulting in being minimally invasive and well-tolerated by patients. This paper reports on the short-term efficacy of this combined technique.
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- 2024
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29. Tunnelized Facial Artery Myomucosal Island Flap: A Modification of the FAMM Flap that Enhance its Reconstructive Versatility.
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Vaira LA, Massarelli O, Lechien JR, Chiesa-Estomba CM, Ayad T, and De Riu G
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Competing Interests: Conflict of InterestNone declared.
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- 2024
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30. The Temporal Subcutaneous Brow Lift with Orbicularis Oculi Muscle Elastic Flap: Technical Considerations, Systematic Review, and Terminology Standardization.
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Pascali M and Massarelli O
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- Humans, Esthetics, Dental, Eyelids surgery, Facial Muscles surgery, Rhytidoplasty methods, Blepharoplasty methods
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Objectives: As the face ages, cosmetic changes in the periorbital region including eyebrow ptosis, sagging in the lateral temporo-orbital region with superior eyelid hooding, ptosis of orbicularis oculi muscle associated with drooping of the malar area with multiple "crow feets", a deeper lid-cheek junction, and malar festoons also occur. All these periorbital structures should be considered as a single anatomical entity., Methods: Numerous techniques have been described to correct brow aesthetics in facial rejuvenation. We report the senior author's (M.P.) current approach utilizing a temporal subcutaneous brow lift (TSBL) associated with an orbicularis oculi muscle (OOM) elastic flap. Furthermore, a systematic review of the literature was performed comparing the different surgical approaches striving to clarify its terminology. A total of 298 patients underwent this procedure in 4 years period. Of these, 230 patients, with at least 12 months of follow-up, were submitted to subjective and objective methods to evaluate the self-perception of scar and their overall aesthetic satisfaction. A committee of experts, blinded to each other's assessment, evaluated the same outcomes. Total eyebrow's tail lift was measured and recorded for each patients., Results: The most satisfying aspect of these techniques is the dramatic periorbital rejuvenation and preservation of the patient's original youthful identity. In fact, the postoperative results appear very natural and do not suffer from an "operated" look. This aspect is noticeable from both the surgeon's and the patient's perceptions. There were no major complications in any of the cases., Conclusions: The proposed TSBL with OOM elastic flap technique, in the hands of senior author (M.P.) has emerged as a reliable, effective, and highly reproducible method to treat sagging and aging of the lateral region of the orbit, even without associated blepharoplasties., Competing Interests: None declared., (Thieme. All rights reserved.)
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- 2023
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31. Tongue Reconstruction with Buccinator Myomucosal Island Flaps: Technical Considerations, Oncologic Safety, Functional Outcomes and QoL Assessment-A Retrospective Observational Study.
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Massarelli O, Vaira LA, Crimi S, Salzano G, Latini L, Bianchi A, Gennaro P, and De Riu G
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The objective of this study was to investigate the effectiveness of buccinator myomucosal island flaps for tongue reconstruction following malignant tumor resections. A retrospective study was performed on 52 patients who underwent tongue reconstructions with buccinator myomucosal island flaps between 2012 and 2020. We reviewed the flap type and size, harvesting time, recipient- and donor-site complications, postoperative oncologic outcomes, functional recovery and QoL assessment. All of the flaps were transposed successfully without any total flap loss. Neither in the primary site nor in the neck were cancer relapses observed. An evaluation of the sensitivity revealed that 96.1% of patients experienced a recovery of touch, two-point and pain sensations. There were significant differences between the flap and the native mucosa in terms of the tactile ( p < 0.001), pain ( p < 0.001) and two-point ( p < 0.001) thresholds. The average swallowing score recorded was 6.1 out of 7, with only minor complaints. The quality of life assessments demonstrated high scores across physical (24.5 out of 28), social (25.8 out of 28), emotional (20.3 out of 24) and functional (25 out of 28) aspects. The present study showed how buccinator myomucosal island flaps represent an effective and functional tongue reconstructive option, requiring a short operative time with a low rate of donor site morbidity, and with evidence of long-term oncologic safety and high quality of life.
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- 2023
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32. A Single-Center Retrospective Analysis of 14 Head and Neck AVMs Cases Treated with a Single-Day Combined Endovascular and Surgical Approach.
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Gennaro P, Cioni S, Bracco S, Cascino F, Latini L, Abbagnato M, Massarelli O, and Gabriele G
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Arteriovenous malformations (AVMs) are rare congenital defects of vascular development whose treatment remains challenging. The paper presents a retrospective single-center study of 14 patients with AVMs of the head and neck region undergoing combined endovascular and surgical treatment in a single day. AVM architecture and therapeutic strategies were determined on the basis of angiographic studies, while the psychological involvement of each patient was assessed by means of a questionnaire. Most of the 14 patients achieved satisfactory clinical results with no recurrences, good aesthetic and functional results, and most patients reported improved quality of life. The combined endovascular and surgical approach is an effective treatment for AVMs of the head and neck and performing it on the same day is a possible option often accepted by patients which guarantees operative advantages for the surgeon.
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- 2023
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33. The "Kite-t-FAMMIF": A Novel Technique for Reconstruction of Extensive Soft Palate Resection.
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Massarelli O and Carnevale C
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Total soft palate reconstruction is a challenge for the head and neck surgeon. Velopharyngeal incompetence resulting from soft palate resection impairs both speech and swallowing and significantly affects the quality of life of the patients. Radial forearm free flap is the reconstructive technique most used worldwide, but it requires microsurgical skills, is associated with high donor site morbidity, and shrinks during the healing process, especially after adjuvant radiotherapy. We present a novel technique using a single "kite-shaped" tunnelized-facial artery myomucosal island flap (t-FAMMIF) and report very favorable functional outcomes. Three patients in whom a kite-shaped flap was used to reconstruct a total soft palate defect after squamous cell carcinoma resection were included. In two of them, the resection included both tonsils due to cancer spreading to the tonsillar fossae. The mucosal and muscular sides of a single t-FAMMIF flap were able to restore the oral and nasal lining of the palate, respectively, without the need to fold the flap. All patients were able to tolerate an oral soft diet 10 days after surgery. No complications were detected. A complete mucosalization on the nasal lining was observed by video-endoscopy 3 weeks after surgery. No case of shrinking of the flap was observed during the follow-up, and speech and swallowing functions were not impaired after complete wound healing. Kite-shaped t-FAMMIF represents an excellent and feasible reconstructive option for extensive postablative soft palate defects., (Copyright © 2022 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The American Society of Plastic Surgeons.)
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- 2022
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34. "Functional trapezius muscle reconstruction after resection of a desmoid tumor using an innervated gracilis free flap".
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De Michele F, Massarelli O, Franza M, Gebbia V, and D'Arpa S
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Desmoid tumors are characterized by indolent growth, progressive invasion of surrounding tissues and a high rate of relapse. We present the case of a desmoid tumor rising from the trapezius of a young woman. Following resection, we performed a functional reconstruction using an innervated gracilis free flap., Competing Interests: None of the authors has any conflict of interest to declare., (© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.)
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- 2022
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35. Recommendations for a safe restart of elective aerosol-generating oral surgery procedures following the COVID-19 pandemic outbreak: An Italian multicenter study.
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Giovanditto F, Soma D, Vaira LA, Pispero A, Lombardi N, Ristoldo F, Mariani U, Pizzi S, Isola A, Smania P, Albanese M, D'Agostino A, Appendino P, Scatà E, Raho MT, Gobbi R, Carta E, Massarelli O, Lumbau A, Spano G, and De Riu G
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- Aerosols, Humans, Pandemics prevention & control, Retrospective Studies, SARS-CoV-2, COVID-19 prevention & control, Oral Surgical Procedures
- Abstract
Among healthcare workers, oral and maxillofacial surgeons are some of the most exposed to coronavirus disease (COVID-19). The aim of this retrospective study was to develop suggestions for continuing the work of oral and maxillofacial surgeons using a safe protocol for elective and urgent aerosol-generating procedures that could prevent the onset of new clusters. Based on the results obtained and a guidelines review of those Asian countries that had promptly managed the current pandemic, the following safety protocol was developed., (Copyright © 2022 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.)
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- 2022
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36. A new aesthetic pretrichial approach for upper third-facial fractures and pathologies: The "Crown incision".
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Massarelli O, Vaira LA, and De Riu G
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- Cicatrix etiology, Cicatrix prevention & control, Esthetics, Humans, Retrospective Studies, Scalp, Skull Fractures, Surgical Wound
- Abstract
Background: The coronal incision represents the cornerstone for the treatment of upper-third maxillofacial pathologies. However, this approach leaves long scars that in numerous patients, it can cause extensive surrounding alopecia and sensory skin deficits. This clinical evidence prompted the authors to propose a full pretrichial incision, the crown incision, in order to overcome these drawbacks., Methods: A retrospective study was performed to investigate and report the aesthetic and functional outcomes of 15 patients treated with this new approach., Results: In the postoperative period, no major or minor complications were detected. The aesthetic evaluation of the scar by the operator and the patient showed overlapping results. The overall rating was 2.93 for the patient and 2.87 for the surgeon, on a scale from 0 (as normal skin) to 10 (very different from normal skin). The recovery of sensitivity in the innervation territories of the supratrochlear and supraorbital nerves was found to be complete in 14 patients. In one case, the sharp/blunt discriminative sensitivity was absent in all three points assessed., Conclusions: This study showed the crown incision to be a safe approach with an optimal recovery of scalp sensitivity and excellent aesthetic results even in bald patients. Therefore, it can be considered a valid aesthetic and effective alternative to the classic coronal approach and should form part of the craniomaxillofacial surgical armamentarium., (Copyright © 2021 Elsevier Ltd. All rights reserved.)
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- 2022
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37. Chimeric LSMAP Double-barrel Fibula Free Flap: Goal-oriented Surgical Technique and Tips for One-stage Mandibular Reconstruction.
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Massarelli O
- Abstract
Composite oromandibular defects involving jaw bones, intraoral and skin/soft tissues, or dynamic structures such as the tongue, soft palate, and pharynx are real reconstructive challenges even today. Despite improvements in oral dental rehabilitation, another complex task to deal with in young patients with dentate or nonatrophic mandible is correcting a too large vertical occlusal dimension, which makes the prosthodontic rehabilitation very challenging. Instead of using more complex and time-consuming methods such as simultaneous free flaps and to avoid further bone graft and second-stage revision procedures, an innovative double-barrel shaped chimeric fibula free flap with lateral supramalleolar artery perforator flap is used to fulfill all of the reconstructive requisites in one-stage. This new operative technique has never been described before. To deal with a complex head and neck reconstruction, the step-by-step harvesting technique, flap design, and inset of flap are described, giving tips and tricks to avoid jeopardizing its vascularity. A proper match between the bone transplant and native mandible, together with a sufficient amount of tissue for proper oropharyngeal reconstruction was achieved in one stage. Both the functional and aesthetic results were excellent, requiring no further revisions in a second stage. The chimeric fibula free flap with lateral supramalleolar artery perforator flap is a novel, versatile, and useful technique that provides a good opportunity for clinicians and patients to achieve adequate prosthetic rehabilitation and improved aesthetics in reconstruction of postablative extensive oromandibular defects in one stage., (Copyright © 2022 The Author. Published by Wolters Kluwer Health, Inc. on behalf of The American Society of Plastic Surgeons.)
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- 2022
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38. Accuracy of Fibula Reconstruction Using Patient-Specific Cad/Cam Plates: A Multicenter Study on 47 Patients.
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Zavattero E, Bolzoni A, Dell'Aversana G, Santagata M, Massarelli O, Ferri A, Della Monaca M, Copelli C, Gessaroli M, Valsecchi S, Borbon C, Beltramini GA, Ramieri G, Valentini V, Tartaro GP, Cocchi R, Varazzani A, Califano L, and Baj A
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- Adult, Anatomic Landmarks diagnostic imaging, Female, Fibula diagnostic imaging, Fibula surgery, Humans, Imaging, Three-Dimensional, Male, Middle Aged, Patient Care Planning, Prospective Studies, Computer-Aided Design, Free Tissue Flaps, Mandibular Reconstruction methods, Patient-Specific Modeling, Surgery, Computer-Assisted methods
- Abstract
Objectives: This prospective study evaluated the accuracy of mandibular reconstruction using free fibular flaps (by comparing virtual plans to the three-dimensional postoperative results), and the extent of bone-to-bone contact after computer-assisted surgery., Methods: We included 65 patients who underwent partial-continuity mandibular resections from February 2013 to January 2017, and evaluated virtual planning, surgical techniques, and accuracy., Results: Forty-seven patients were analysed. A total of 112 fibular segments received 54 implants. We measured 227 distances between landmarks to assess the accuracy of reconstruction. Postoperative reconstruction accuracy ranged from 0.5 to 3 mm., Conclusion: Virtual surgical planning very accurately translated simulation into reality, particularly in patients requiring large, complex mandibular reconstructions using multiple fibular segments., Level of Evidence: 4 Laryngoscope, 131:E2169-E2175, 2021., (© 2021 The American Laryngological, Rhinological and Otological Society, Inc.)
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- 2021
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39. Comment on: Reconstruction using facial artery system-based flaps. One vascular system for multiple purposes in head and neck reconstructive surgery.
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Massarelli O, Vaira LA, and De Riu G
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- Arteries surgery, Humans, Plastic Surgery Procedures, Surgical Flaps
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- 2021
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40. Platform switching versus regular platform single implants: 5-year post-loading results from a randomised controlled trial.
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Meloni SM, Lumbau A, Baldoni E, Pisano M, Spano G, Massarelli O, and Tallarico M
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- Bicuspid, Crowns, Humans, Torque, Dental Implants, Immediate Dental Implant Loading
- Abstract
Purpose: To compare the clinical and radiographic outcomes of platform switching (PS) and regular platform (RP) implants., Materials and Methods: This study was designed as a randomised controlled split-mouth trial. Eighteen patients, with bilaterally missing single premolars or molars to be restored with implant-supported single crowns, were consecutively enrolled. Implant sites were randomly assigned to be treated according to the PS concept (PS group), or with matching implant-abutment diameters (RP group). A total of 36 implants were placed in healed bone, with an insertion torque between 35 and 45 Ncm, according to a one-stage protocol. All the implants were loaded with a screw-retained provisional crown 3 months after implant insertion. Definitive screw-retained single crowns were delivered 2 months later. Outcome measures were implant and prosthetic survival rates, biological and prosthetic complications, marginal bone level (MBL) changes, pocket probing depth (PPD) and bleeding on probing (BOP). Clinical data were collected at implant placement (baseline), implant loading (3 months later) and at 9, 36 and 60 months after loading., Results: One patient dropped out after 4 years of follow-up. No implant failed and no prosthetic complications were recorded during the study period. One patient experienced mucosal inflammation with positive BOP (RP group) after 3 months and three patients had bilateral peri-implant mucosal inflammation with positive BOP at 6, 24 and 36 months, respectively. No other biological complications were recorded up to 60 months of follow-up. There were no statistically significant differences between groups for complications (3/18 versus 4/18; P = 1.0). Nine months after loading the mean MBL was 0.93 ± 0.26 mm (95% CI 0.81 to 1.05) for RP implants and 0.84 ± 0.23 mm (95% CI 0.73 to 0.95) for PS implants. No statistically significant difference was observed between the groups (P = 0.18). Thirty-six months after loading, the mean MBL was 1.09 ± 0.31 mm (95% CI 0.95 to 1.24) in the RP group and 1.06 ± 0.24 mm (95% CI 0.94 to 1.17) in the PS group, with no statistically significant difference between groups (P = 0.70). Sixty months after loading the mean MBL was 1.24 ± 0.39 mm (95% CI 1.05 to 1.43) in the RP group and 1.20 ± 0.21 mm (95% CI 1.01 to 1.39) in the PS group, with no statistically significant difference between the groups (P = 0.85). The mean PPD was 2.58 ± 0.58 mm (95% CI 2.32 to 2.84) in the RP group and 2.40 ± 0.72 mm (95% CI 2.21 to 2.59) in the PS group at 60 months follow-up, with no statistically significant difference between the groups (P = 0.49). The mean BOP was 0.90 ± 0.88 (95% CI 0.58 to 1.22) in the RP group and 0.93 ± 0.97 (95% CI 0.51 to 1.35) in the PS group at 60 months of follow-up, with no statistically significant difference between the groups (P = 0.85)., Conclusions: Implants restored according to the PS concept and matching implant-abutment diameters showed comparable clinical and radiographic results up to 5 years after loading., Competing Interests: Conflict-of-interest statement: This study was not supported by any company. All the authors declare no conflicts of interest.
- Published
- 2020
41. Fibula free flap pedicle ossification: Experience of two centres and a review of the literature.
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Baserga C, Massarelli O, Bolzoni AR, Rossi DS, Beltramini GA, Baj A, and Giannì AB
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- Adult, Female, Humans, Male, Middle Aged, Radiography, Panoramic, Plastic Surgery Procedures, Reoperation, Tomography, X-Ray Computed, Fibula transplantation, Free Tissue Flaps, Maxillary Neoplasms diagnostic imaging, Maxillary Neoplasms surgery, Ossification, Heterotopic diagnostic imaging, Ossification, Heterotopic surgery, Postoperative Complications diagnostic imaging, Postoperative Complications surgery
- Abstract
Purpose: The osteogenic potential of vascularized periosteum has been described in a few cases in the literature, and many different factors have been pointed out as plausible. Our aim was to review the literature in order to give a complete overview of this topic and to report on our clinical experience., Patients & Methods: Our experience includes three patients who underwent maxillectomy and FFF reconstruction. A progressive reduction in mouth opening was noticed in the months after surgery, and CT scans showed calcified tissue around the pedicle. Surgical revisions were performed. No recurrences were noticed. A full systematic literature review was conducted, including studies published on or before September 2016., Results: Clinically, free flap pedicle ossification is presented as trismus, hard swelling, and severe pain during movements, although the diagnosis is scarce and often fortuitous. From January 2010 to January 2016 we performed 68 FFF reconstructions, and the incidence of FFF pedicle ossification in our experience was 4.4%., Conclusion: Ossification of FFF pedicle is uncommon, but when it occurs, it has dramatic clinical consequences. Follow-up CT scan can be useful in diagnosis. In our experience, surgery should be performed only when the patient is symptomatic., (Copyright © 2018 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2018
- Full Text
- View/download PDF
42. Tactile recovery assessment with shortened Semmes-Weinstein monofilaments in patients with buccinator myomucosal flap oral cavity reconstructions.
- Author
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Vaira LA, Massarelli O, Gobbi R, Biglio A, and De Riu G
- Subjects
- Cheek surgery, Facial Muscles surgery, Humans, Mouth Mucosa surgery, Mouth surgery, Pain Measurement instrumentation, Pain Threshold physiology, Plastic Surgery Procedures methods, Surgical Flaps surgery
- Abstract
Background: The sensitive restoration is a primary aim of oral reconstructive surgery. The Semmes-Weinstein monofilament test is the "Gold Standard" to assess the threshold of tactile sensitivity on the skin but its use in the oral cavity is limited due to the size of the tools. We adopted half-cut Semmes-Weinstein monofilaments to evaluate the threshold of tactile sensitivity in oral reconstructions with buccinator myomucosal flaps., Materials and Methods: Monofilaments were half-cut and recalibrated. Fifty-seven oral reconstructions were considered at 4-year minimum follow-up. Test was conducted both on the reconstructive flap and on the non-operated contralateral side., Results: All of the considered flaps (100%) showed a recovery of tactile sensitivity. The overall average tactile threshold value assessed on this sample was 0.76 ± 1.58 g/mm
2 overall., Conclusions: Shortened monofilaments allow easily assessment of tactile sensitivity in all the oral cavity areas, even in operated patients which often present lockjaw or microstomia.- Published
- 2018
- Full Text
- View/download PDF
43. Comment on: Facial Artery Myomucosal Flap, Pedicled Solely on the Facial Artery: Experimental Design Study on Survival.
- Author
-
Massarelli O, Vaira LA, and De Riu G
- Subjects
- Arteries, Surgical Flaps, Plastic Surgery Procedures, Research Design
- Published
- 2018
- Full Text
- View/download PDF
44. Aesthetic and Functional Evaluation of Total Nasal Reconstructions.
- Author
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Vaira LA, Massarelli O, Deiana G, Meloni SM, Dell'aversana Orabona G, Piombino P, and De Riu G
- Abstract
The loss of a portion or the totality of the nose has great relevance on the perception of the beauty of a face and can result in a catastrophic quality of life impairment. Several surgical techniques are currently available for the reconstruction of the nasal pyramid. However, there are very few nasal reconstruction quality evaluation protocols that allow the surgeon to choose objectively the best technique for each kind of defects. Six total nasal reconstruction performed in University of Sassari Maxillofacial Unit were evaluated with a protocol that investigate objectively and subjectively the surgical aesthetic and functional outcome. Sensitivity recovery on the reconstructive flaps was also assessed. Patients reported a satisfactory nasal reconstruction both functionally and aesthetically. Sensitivity recovery on the forehead flap was always present even after pedicle resection or in case of traumatic section of the infraorbital nerve. The use of a three layer reconstruction has proved a viable technique both aesthetically and functionally. In particular the use of the forehead flap to reconstruct the outer layer of the nose allows to carry a tissue with very similar characteristics to the original with a recovery of the sensitivity almost complete., Competing Interests: Compliance with Ethical StandardsThe authors declare that they have no conflict of interest.This study is approved by University of Sassari Ethical committee.Additional informed consent was obtained from all individual participants for whom identifying information is included in this article.
- Published
- 2018
- Full Text
- View/download PDF
45. Sensory recovery of myomucosal flap oral cavity reconstructions.
- Author
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Massarelli O, Vaira LA, Biglio A, Gobbi R, Dell'aversana Orabona G, and De Riu G
- Subjects
- Aged, Female, Humans, Male, Middle Aged, Mouth physiopathology, Neurologic Examination methods, Retrospective Studies, Mouth surgery, Plastic Surgery Procedures methods, Recovery of Function physiology, Sensation physiology, Surgical Flaps physiology
- Abstract
Background: Sensory restoration of the oral cavity is a primary aim of reconstructive surgery in posttraumatic or postablative defects. Sensitivity plays a key role in oral function, whose impairment strongly affects the patient's quality of life. Cheek myomucosal flaps provide a reliable and tissue-like reconstruction of these regions but their sensitive recovery, which we still know little about, deserves thorough assessment., Methods: In this retrospective study, the myomucosal cheek flaps were tested for different aspects of sensory recovery: touch; 2-point discrimination; pain; sharp/smooth discrimination; ability to feel hot/cold stimulus; stereognosis; and taste., Results: Fifty-two myomucosal flap reconstructions were investigated. All sensitivity tests showed positive results. When comparison was possible, sensitivity seemed significantly close to the contralateral healthy side. Sensory recovery proved to be even better than that reported on reinnervated microvascular free flap reconstructions of the oral cavity., Conclusion: Myomucosal flap reconstruction demonstrated a high degree of sensory recovery., (© 2017 Wiley Periodicals, Inc.)
- Published
- 2018
- Full Text
- View/download PDF
46. Perivascular Epithelioid Cell Tumour with Intraorbital Location: Report of a Case and Review of the Literature.
- Author
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Lubo I, Fermín I, Massarelli O, Gobbi R, and Cossu Rocca P
- Abstract
The Perivascular Epithelioid Cell tumours (PEComas) are rare mesenchymal neoplasms recognized as entity by the World Health Organization. The tumour cells have an uncertain origin and are characterized by distinctive histological and immunohistochemical features. We report a case of PEComa occurring as intraorbital lesion in a 47-year-old man. We found only two other cases described in the literature and we considered all three cases together in order of histology, immunohistochemistry, and clinical outcome. We found a strict histological overlapping and quite similar immunohistological results. All three cases showed a favourable clinical course probably related to small size of tumours (<5 cm), low mitotic rate (<2 mitoses in 50 HPF), and absence of necrosis.
- Published
- 2016
- Full Text
- View/download PDF
47. Guided implant surgery after free-flap reconstruction: Four-year results from a prospective clinical trial.
- Author
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Meloni SM, Tallarico M, De Riu G, Pisano M, Deledda A, Lolli FM, Massarelli O, and Tullio A
- Subjects
- Alveolar Bone Loss etiology, Bone Remodeling physiology, Bone Transplantation methods, Dental Implantation, Endosseous instrumentation, Dental Implants, Dental Prosthesis, Implant-Supported, Dental Restoration Failure, Female, Follow-Up Studies, Humans, Jaw injuries, Jaw Neoplasms surgery, Male, Mandibular Reconstruction instrumentation, Middle Aged, Myocutaneous Flap transplantation, Orthognathic Surgical Procedures, Patient Satisfaction, Periodontal Index, Postoperative Complications, Prospective Studies, Surgery, Computer-Assisted instrumentation, Survival Analysis, Treatment Outcome, Wounds, Gunshot surgery, Dental Implantation, Endosseous methods, Free Tissue Flaps transplantation, Mandibular Reconstruction methods, Surgery, Computer-Assisted methods
- Abstract
Aim: The aim of this prospective clinical study is to assess the 4-year outcomes of implant-supported restorations performed using a computer-guided template-assisted flapless implant surgery approach in patients reconstructed with fibula or iliac crest free flaps., Materials and Methods: Twelve jaws in 10 patients were reconstructed with osteomyocutaneous free flap after tumour resection or gunshot wound, after complete healing computer-assisted template-based flapless implant placement, based on prosthetic and aesthetic analysis, was performed using a customized protocol. Treatment success was evaluated using the following parameters: survival of implants/prostheses, prosthetic and biologic complications, marginal bone remodelling, soft tissue parameters and patient satisfaction., Results: A total of 56 implants were placed; the implants ranged between 8 and 16 mm in length and were either 3.5, 4.3 or 5 mm wide. All the patients have reached the 4-year follow-up. Three implants were lost accounting for an overall implant survival rate of 94.6%. No prosthesis were lost. Some complications were recorded. Four years after loading the mean marginal bone loss was 1.43 ± 0.49 mm at the palatal/lingual site and 1.48 ± 0.46 mm at the vestibular site. All the patients showed healthy soft tissues with stable probing depth (4 .93 ± 0.75%) and successful bleeding on probing values (12 ± 5.8%); 90% of patients were satisfied of the treatment at the 4-year follow-up., Conclusions: Computer-guided template-assisted flapless implant surgery seems to be a viable option for patients undergoing reconstruction with free flaps after tumour resection or gunshot trauma, although many challenges remain. A high degree of patient satisfactorily was reported., (Copyright © 2015 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2015
- Full Text
- View/download PDF
48. Chimeric lateral supramalleolar artery perforator fibula free flap in the reconstruction of composite head and neck defects.
- Author
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Massarelli O, Gobbi R, Biglio A, Soma D, and Tullio A
- Subjects
- Adult, Aged, Arteries transplantation, Facial Injuries surgery, Fibula blood supply, Humans, Male, Maxilla surgery, Middle Aged, Plastic Surgery Procedures methods, Retrospective Studies, Carcinoma, Squamous Cell surgery, Fibula transplantation, Oropharyngeal Neoplasms surgery, Orthognathic Surgical Procedures methods, Perforator Flap blood supply, Wounds, Gunshot surgery
- Abstract
The authors evaluate the use of an osteomyocutaneous fibula free flap, combined in a chimeric fashion, with a lateral supramalleolar flap, in 10 patients with composite head and neck defects. All reconstructions were performed successfully. With the exception of one patient who died after disease recurrence, all patients were decannulated and resumed an oral diet. Speech intelligibility was good in seven of 10 patients. Dental implants were used in two of 10 patients, with a total of 10 fixtures placed successfully. The donor site healed without complications in all except one case, where necrosis of the skin graft occurred with fungal infection. The chimeric lateral supramalleolar artery perforator fibula free flap may be a valid option for maximizing the quality of life in patients with composite oromandibular defects.
- Published
- 2014
- Full Text
- View/download PDF
49. Facial artery myomucosal free flap for cheek mucosa reconstruction: a case report.
- Author
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Massarelli O, Gobbi R, Biglio A, and Tullio A
- Subjects
- Aged, Free Tissue Flaps blood supply, Humans, Male, Carcinoma, Squamous Cell surgery, Cheek surgery, Free Tissue Flaps transplantation, Mouth Mucosa surgery, Mouth Neoplasms surgery, Plastic Surgery Procedures methods
- Abstract
Squamous cell carcinoma (SCC) of the buccal mucosa is an aggressive form of oral cancer. It tends to spread to adjacent tissues and often metastasizes to occult cervical node. There are multiple techniques for cheek reconstruction after tumor removal, including temporalis myocutaneous and temporoparietal fascial pedicled flaps and a forearm free flap. In this report, a case of a 76-year-old man with SCC of the left cheek mucosa and extending to the posterolateral superior alveolar ridge is presented. The patient underwent radical excision of the tumor, omolateral modified radical neck dissection (MRND-III), and contralateral selective neck dissection (levels I-III). Reconstruction was performed with a facial artery myomucosal free flap. The flap was transplanted successfully, and there were no donor or recipient site complications. This technique is a good reconstructive option because of its adherence to the plastic surgery principle of "replacing like with like" and its minimal donor-site morbidity., (Copyright © 2013 Wiley Periodicals, Inc.)
- Published
- 2013
- Full Text
- View/download PDF
50. Minimally invasive harvest of free fibula flap.
- Author
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Baj A, Beltramini GA, Massarelli O, Youssef DA, and Giannì AB
- Subjects
- Adolescent, Female, Humans, Male, Middle Aged, Minimally Invasive Surgical Procedures, Video Recording, Young Adult, Fibula transplantation, Free Tissue Flaps, Tissue and Organ Harvesting methods
- Published
- 2013
- Full Text
- View/download PDF
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