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1. Does Health Education Through Videos and E-Leaflet Have a Good Influence on Improving Students’ Reproductive Health Knowledge, Attitudes, and Practices? an Intervention Study in Jatinangor, Indonesia

Author

Yuliasih ND, Sari P, Bestari AD, Martini N, and Sujatmiko B

Subjects
health education, knowledge, attitude, practice, reproductive health, Special aspects of education, LC8-6691, Medicine (General), R5-920
Abstract

Neneng Dewi Yuliasih,1 Puspa Sari,1,2 Astuti Dyah Bestari,1,2 Neneng Martini,1,2 Budi Sujatmiko2 1Midwifery Program, Faculty of Medicine, Universitas Padjadjaran, Sumedang, West Java, Indonesia; 2Department of Public Health, Faculty of Medicine, Universitas Padjadjaran, Sumedang, West Java, IndonesiaCorrespondence: Puspa Sari, Midwifery Program, Department of Public Health, Faculty of Medicine, Universitas Padjadjaran, Eyckman 38, Bandung, West Java, 40161, Indonesia, Tel +62 022 2032170, Email puspa.sari@unpad.ac.idBackground: Reproductive health issues remain a serious concern, especially for university students. The problem occurs due to a lack of knowledge about three primary threats to adolescent reproductive health, namely, sexuality, HIV / AIDS, and drug abuse, which will affect the attitudes and practices that university students will adopt related to reproductive health. This study aims to analyze the effect of reproductive health education through videos and e-leaflets on improving students’ reproductive health knowledge, attitudes, and practices. The hypothesis for this study was to explore the differences in knowledge, attitudes, and practices before and after the intervention.Methods: This study used a quasi-experimental design. Purposive sampling was used to select participants from four universities in the Jatinangor District. 166 female first-year university students were divided into the study group through video (n = 83) and the control group through e-leaflet (n = 83). A structured questionnaire assessed reproductive health knowledge, attitude, and behavior before and after the intervention. SPSS version 27.0 was used to analyze the data.Results: This study showed that university students’ knowledge, attitudes, and practice increased significantly after the intervention (p< 0.001). The comparison results between the intervention group and the control group did not show a significant difference in knowledge improvement (p> 0.001); however, they showed differences in attitude and behavior improvement (p< 0.001).Conclusion: Reproductive health education through video and e-leaflets is equally effective in improving first-year students’ knowledge, attitude, and practice. University support is necessary for reproductive health education among students.Keywords: health education, knowledge, attitude, practice, reproductive health

Published
2025

2. First demonstration of 30 eVee ionization energy resolution with Ricochet germanium cryogenic bolometers

Author

Augier, C., Baulieu, G., Belov, V., Bergé, L., Billard, J., Bres, G., Bret, J. -L., Broniatowski, A., Calvo, M., Cazes, A., Chaize, D., Chala, M., Chapellier, M., Chaplinsky, L., Chemin, G., Chen, R., Colas, J., Cudmore, E., De Jesus, M., de Marcillac, P., Dumoulin, L., Exshaw, O., Ferriol, S., Figueroa-Feliciano, E., Filippini, J. -B., Formaggio, J. A., Fuard, S., Gascon, J., Giuliani, A., Goupy, J., Goy, C., Guerin, C., Guy, E., Harrington, P., Hertel, S. A., Heusch, M., Hong, Z., Ianigro, J. -C., Jin, Y., Juillard, A., Karaivanov, D., Kazarcev, S., Lamblin, J., Lattaud, H., Li, M., Lubashevskiy, A., Marnieros, S., Martini, N., Mayer, D. W., Minet, J., Monfardini, A., Mounier, F., Novati, V., Olivieri, E., Oriol, C., Mateo, L. Ovalle, Patel, P. K., Perbet, E., Pinckney, H. D., Poda, D. V., Ponomarev, D., Rarbi, F., Real, J. -S., Redon, T., Reyes, F. C., Robert, A., Rozov, S., Rozova, I., Scorza, S., Schmidt, B., Shevchik, Ye., Soldner, T., Stachurska, J., Stutz, A., Vagneron, L., Van De Pontseele, W., Vezzu, F., Winslow, L., Yakushev, E., and Zinatulina, D.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

The future Ricochet experiment aims to search for new physics in the electroweak sector by measuring the Coherent Elastic Neutrino-Nucleus Scattering process from reactor antineutrinos with high precision down to the sub-100 eV nuclear recoil energy range. While the Ricochet collaboration is currently building the experimental setup at the reactor site, it is also finalizing the cryogenic detector arrays that will be integrated into the cryostat at the Institut Laue Langevin in early 2024. In this paper, we report on recent progress from the Ge cryogenic detector technology, called the CryoCube. More specifically, we present the first demonstration of a 30~eVee (electron equivalent) baseline ionization resolution (RMS) achieved with an early design of the detector assembly and its dedicated High Electron Mobility Transistor (HEMT) based front-end electronics. This represents an order of magnitude improvement over the best ionization resolutions obtained on similar heat-and-ionization germanium cryogenic detectors from the EDELWEISS and SuperCDMS dark matter experiments, and a factor of three improvement compared to the first fully-cryogenic HEMT-based preamplifier coupled to a CDMS-II germanium detector. Additionally, we discuss the implications of these results in the context of the future Ricochet experiment and its expected background mitigation performance., Comment: 10 pages, 5 figures, 1 table

Published
2023

3. Results from a Prototype TES Detector for the Ricochet Experiment

Author

Ricochet Collaboration, Augier, C., Baulieu, G., Belov, V., Bergé, L., Billard, J., Bres, G., Bret, J-. L., Broniatowski, A., Calvo, M., Cazes, A., Chaize, D., Chala, M., Chang, C. L., Chapellier, M., Chaplinsky, L., Chemin, G., Chen, R., Colas, J., Cudmore, E., De Jesus, M., de Marcillac, P., Dumoulin, L., Exshaw, O., Ferriol, S., Figueroa-Feliciano, E., Filippini, J. -B., Formaggio, J. A., Fuard, S., Gannon, K., Gascon, J., Giuliani, A., Goupy, J., Goy, C., Guerin, C., Guy, E., Harrington, P., Hertel, S. A., Heusch, M., Hong, Z., Ianigro, J. -C., Jin, Y., Juillard, A., Karaivanov, D., Kazarcev, S., Lamblin, J., Lattaud, H., Li, M., Lisovenko, M., Lubashevskiy, A., Marnieros, S., Martini, N., Mayer, D. W., Minet, J., Monfardini, A., Mounier, F., Novati, V., Olivieri, E., Oriol, C., Mateo, L. Ovalle, Palladino, K. J., Patel, P. K., Perbet, E., Pinckney, H. D., Poda, D. V., Ponomarev, D., Rarbi, F., Real, J. -S., Redon, T., Reyes, F. C., Ricol, J. -S., Robert, A., Rozov, S., Rozova, I., Salagnac, T., Schmidt, B., Scorza, S., Shevchik, Ye., Soldner, T., Stachurska, J., Stutz, A., Vagneron, L., Van De Pontseele, W., Veihmeyer, C., Vezzu, F., Wang, G., Winslow, L., Yakushev, E., Yefremenko, V. G., Zhang, J., and Zinatulina, D.

Subjects
Physics - Instrumentation and Detectors
Abstract

Coherent elastic neutrino-nucleus scattering (CE$\nu$NS) offers valuable sensitivity to physics beyond the Standard Model. The Ricochet experiment will use cryogenic solid-state detectors to perform a precision measurement of the CE$\nu$NS spectrum induced by the high neutrino flux from the Institut Laue-Langevin nuclear reactor. The experiment will employ an array of detectors, each with a mass of $\sim$30 g and a targeted energy threshold of 50 eV. Nine of these detectors (the "Q-Array") will be based on a novel Transition-Edge Sensor (TES) readout style, in which the TES devices are thermally coupled to the absorber using a gold wire bond. We present initial characterization of a Q-Array-style detector using a 1 gram silicon absorber, obtaining a baseline root-mean-square resolution of less than 40 eV., Comment: 18 pages, 8 figures

Published
2023
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4. Tagging and localisation of ionizing events using NbSi transition edge phonon sensors for Dark Matter searches

Author

EDELWEISS Collaboration, Augier, C., Benoît, A., Bergé, L., Billard, J., Broniatowski, A., Camus, P., Cazes, A., Chapellier, M., Charlieux, F., Colas, J., De Jésus, M., Dumoulin, L., Eitel, K., Filippini, J. B., Filosofov, D., Gascon, J., Giuliani, A., Gros, M., Guy, E., Jin, Y., Juillard, A., Lattaud, H., Marnieros, S., Martini, N., Navick, X. -F., Nones, C., Olivieri, E., Oriol, C., Pari, P., Paul, B., Poda, D., Rojas, A., Rozov, S., Sanglard, V., Vagneron, L., Yakushev, E., Zolotarova, A., and Kavanagh, B. J.

Subjects
Physics - Instrumentation and Detectors, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

In the context of direct searches of sub-GeV Dark Matter particles with germanium detectors, the EDELWEISS collaboration has tested a new technique to tag ionizing events using NbSi transition edge athermal phonon sensors. The emission of the athermal phonons generated by the Neganov-Trofimov-Luke effect associated with the drift of electrons and holes through the detectors is used to tag ionization events generated in specific parts of the detector localized in front of the NbSi sensor and to reject by more than a factor 5 (at 90% C.L.) the background from heat-only events that dominates the spectrum above 3 keV. This method is able to improve by a factor 2.8 the previous limit on spin-independent interactions of 1 GeV/c2 WIMPs obtained with the same detector and data set but without this tagging technique., Comment: 13 pages, 11 figures

Published
2023
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5. The EUCLID VIS read-out shutter unit: a low disturbance mechanism at cryogenic temperature

Author

Larchevêque, C., Genolet, L., Bozzo, E., Paltani, S., Manzoni, D., Castelli, M., Heurteau, J-P., Thomas, C., Constant, J., Michaud, R., Marrei, A., Martini, N., and Verhegge, T.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

Euclid is the second medium-size mission (M2) of the ESA Cosmic Vision Program, currently scheduled for a launch in 2020. The two instruments on-board Euclid, VIS (VISible imager) and NISP (Near Infrared Spectrometer and Photometer), will provide key measurements to investigate the nature of dark energy, advancing our knowledge on cosmology. We present in this contribution the development and manufacturing status of the VIS Read-out Shutter Unit, whose main function is to prevent direct light from falling onto the VIS CCDs during the read-out of the scientific exposures and to allow the dark-current/bias calibrations of the instrument., Comment: 17th European Space Mechanisms and Tribology Symposium, Proceedings of the conference held 20-22 September, 2017 in Hatfield (Hertfordshire), United Kingdom

Published
2018

6. An automatic deep learning approach for coronary artery calcium segmentation

Author

Santini, G., Della Latta, D., Martini, N., Valvano, G., Gori, A., Ripoli, A., Susini, C. L., Landini, L., and Chiappino, D.

Subjects
Computer Science - Computer Vision and Pattern Recognition
Abstract

Coronary artery calcium (CAC) is a significant marker of atherosclerosis and cardiovascular events. In this work we present a system for the automatic quantification of calcium score in ECG-triggered non-contrast enhanced cardiac computed tomography (CT) images. The proposed system uses a supervised deep learning algorithm, i.e. convolutional neural network (CNN) for the segmentation and classification of candidate lesions as coronary or not, previously extracted in the region of the heart using a cardiac atlas. We trained our network with 45 CT volumes; 18 volumes were used to validate the model and 56 to test it. Individual lesions were detected with a sensitivity of 91.24%, a specificity of 95.37% and a positive predicted value (PPV) of 90.5%; comparing calcium score obtained by the system and calcium score manually evaluated by an expert operator, a Pearson coefficient of 0.983 was obtained. A high agreement (Cohen's k = 0.879) between manual and automatic risk prediction was also observed. These results demonstrated that convolutional neural networks can be effectively applied for the automatic segmentation and classification of coronary calcifications.

Published
2017
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10. First demonstration of 30 eVee ionization energy resolution with Ricochet germanium cryogenic bolometers

Author

Augier, C., Baulieu, G., Belov, V., Bergé, L., Billard, J., Bres, G., Bret, J. -. L., Broniatowski, A., Calvo, M., Cazes, A., Chaize, D., Chala, M., Chapellier, M., Chaplinsky, L., Chemin, G., Chen, R., Colas, J., Cudmore, E., De Jesus, M., de Marcillac, P., Dumoulin, L., Exshaw, O., Ferriol, S., Figueroa-Feliciano, E., Filippini, J.-B., Formaggio, J. A., Fuard, S., Gascon, J., Giuliani, A., Goupy, J., Goy, C., Guerin, C., Guy, E., Harrington, P., Hertel, S. A., Heusch, M., Hong, Z., Ianigro, J.-C., Jin, Y., Juillard, A., Karaivanov, D., Kazarcev, S., Lamblin, J., Lattaud, H., Li, M., Lubashevskiy, A., Marnieros, S., Martini, N., Mayer, D. W., Minet, J., Monfardini, A., Mounier, F., Novati, V., Olivieri, E., Oriol, C., Mateo, L. Ovalle, Patel, P. K., Perbet, E., Pinckney, H. D., Poda, D. V., Ponomarev, D., Rarbi, F., Real, J.-S., Redon, T., Reyes, F. C., Robert, A., Rozov, S., Rozova, I., Scorza, S., Schmidt, B., Shevchik, Ye., Soldner, T., Stachurska, J., Stutz, A., Vagneron, L., Van De Pontseele, W., Vezzu, F., Winslow, L., Yakushev, E., Zinatulina, D., Augier, C., Baulieu, G., Belov, V., Bergé, L., Billard, J., Bres, G., Bret, J. -. L., Broniatowski, A., Calvo, M., Cazes, A., Chaize, D., Chala, M., Chapellier, M., Chaplinsky, L., Chemin, G., Chen, R., Colas, J., Cudmore, E., De Jesus, M., de Marcillac, P., Dumoulin, L., Exshaw, O., Ferriol, S., Figueroa-Feliciano, E., Filippini, J.-B., Formaggio, J. A., Fuard, S., Gascon, J., Giuliani, A., Goupy, J., Goy, C., Guerin, C., Guy, E., Harrington, P., Hertel, S. A., Heusch, M., Hong, Z., Ianigro, J.-C., Jin, Y., Juillard, A., Karaivanov, D., Kazarcev, S., Lamblin, J., Lattaud, H., Li, M., Lubashevskiy, A., Marnieros, S., Martini, N., Mayer, D. W., Minet, J., Monfardini, A., Mounier, F., Novati, V., Olivieri, E., Oriol, C., Mateo, L. Ovalle, Patel, P. K., Perbet, E., Pinckney, H. D., Poda, D. V., Ponomarev, D., Rarbi, F., Real, J.-S., Redon, T., Reyes, F. C., Robert, A., Rozov, S., Rozova, I., Scorza, S., Schmidt, B., Shevchik, Ye., Soldner, T., Stachurska, J., Stutz, A., Vagneron, L., Van De Pontseele, W., Vezzu, F., Winslow, L., Yakushev, E., and Zinatulina, D.

Abstract

The future Ricochet experiment aims to search for new physics in the electroweak sector by measuring the Coherent Elastic Neutrino-Nucleus Scattering process from reactor antineutrinos with high precision down to the sub-100 eV nuclear recoil energy range. While the Ricochet collaboration is currently building the experimental setup at the reactor site, it is also finalizing the cryogenic detector arrays that will be integrated into the cryostat at the Institut Laue Langevin in early 2024. In this paper, we report on recent progress from the Ge cryogenic detector technology, called the CryoCube. More specifically, we present the first demonstration of a 30 eVee (electron equivalent) baseline ionization resolution (RMS) achieved with an early design of the detector assembly and its dedicated High Electron Mobility Transistor (HEMT) based front-end electronics with a total input capacitance of about 40 pF. This represents an order of magnitude improvement over the best ionization resolutions obtained on similar phonon-and-ionization germanium cryogenic detectors from the EDELWEISS and SuperCDMS dark matter experiments, and a factor of three improvement compared to the first fully-cryogenic HEMT-based preamplifier coupled to a CDMS-II germanium detector with a total input capacitance of 250 pF. Additionally, we discuss the implications of these results in the context of the future Ricochet experiment and its expected background mitigation performance.

Published
2024

13. PT8 Five-Year Healthcare Resource Consumption and Direct Costs of Women with a New Diagnosis of Hr+/HER2- Breast Cancer Primary or Advanced: Analysis of a Large Italian Administrative Database

Author

Dell'Anno, I., primary, Ronconi, G., additional, Dondi, L., additional, Calabria, S., additional, Piccinni, C., additional, Esposito, I., additional, Addesi, A., additional, Pedrini, A., additional, Maggioni, A.P., additional, and Martini, N., additional

Published
2023
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14. EPH200 Healthcare Resource Consumption of Patients with Chronic Obstructive Pulmonary Disease Treated with Triple and Dual Therapy and Experiencing an Acute Exacerbation

Author

Calabria, S., primary, Ronconi, G., additional, Dondi, L., additional, Piccinni, C., additional, Dell'Anno, I., additional, Pedrini, A., additional, Esposito, I., additional, Brignoli, O., additional, Canonica, G.W., additional, Carone, M., additional, Di Marco, F., additional, Micheletto, C., additional, Vancheri, C., additional, and Martini, N., additional

Published
2023
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19. Results from a prototype TES detector for the Ricochet experiment

Author

Augier, C., primary, Baulieu, G., additional, Belov, V., additional, Bergé, L., additional, Billard, J., additional, Bres, G., additional, Bret, J-.L., additional, Broniatowski, A., additional, Calvo, M., additional, Cazes, A., additional, Chaize, D., additional, Chala, M., additional, Chang, C.L., additional, Chapellier, M., additional, Chaplinsky, L., additional, Chemin, G., additional, Chen, R., additional, Colas, J., additional, Cudmore, E., additional, De Jesus, M., additional, de Marcillac, P., additional, Dumoulin, L., additional, Exshaw, O., additional, Ferriol, S., additional, Figueroa-Feliciano, E., additional, Filippini, J.-B., additional, Formaggio, J.A., additional, Fuard, S., additional, Gannon, K., additional, Gascon, J., additional, Giuliani, A., additional, Goupy, J., additional, Goy, C., additional, Guerin, C., additional, Guy, E., additional, Harrington, P., additional, Hertel, S.A., additional, Heusch, M., additional, Hong, Z., additional, Ianigro, J.-C., additional, Jin, Y., additional, Juillard, A., additional, Karaivanov, D., additional, Kazarcev, S., additional, Lamblin, J., additional, Lattaud, H., additional, Li, M., additional, Lisovenko, M., additional, Lubashevskiy, A., additional, Marnieros, S., additional, Martini, N., additional, Mayer, D.W., additional, Minet, J., additional, Monfardini, A., additional, Mounier, F., additional, Novati, V., additional, Olivieri, E., additional, Oriol, C., additional, Mateo, L. Ovalle, additional, Palladino, K.J., additional, Patel, P.K., additional, Perbet, E., additional, Pinckney, H.D., additional, Poda, D.V., additional, Ponomarev, D., additional, Rarbi, F., additional, Real, J.-S., additional, Redon, T., additional, Reyes, F.C., additional, Ricol, J.-S., additional, Robert, A., additional, Rozov, S., additional, Rozova, I., additional, Salagnac, T., additional, Schmidt, B., additional, Scorza, S., additional, Shevchik, Ye., additional, Soldner, T., additional, Stachurska, J., additional, Stutz, A., additional, Vagneron, L., additional, Van De Pontseele, W., additional, Veihmeyer, C., additional, Vezzu, F., additional, Wang, G., additional, Winslow, L., additional, Yakushev, E., additional, Yefremenko, V.G., additional, Zhang, J., additional, and Zinatulina, D., additional

Published
2023
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24. Cost-Effectiveness of Posthospital Management of Acute Coronary Syndrome: A Real-World Investigation From Italy

Author

Rea, F, Ronco, R, Martini, N, Maggioni, A, Corrao, G, Rea F., Ronco R., Martini N., Maggioni A. P., Corrao G., Rea, F, Ronco, R, Martini, N, Maggioni, A, Corrao, G, Rea F., Ronco R., Martini N., Maggioni A. P., and Corrao G.

Abstract

Objectives: This study aimed to assess the cost-effectiveness profile of adherence to recommendations for the community management of patients discharged with a diagnosis of acute coronary syndrome (ACS). Methods: The cohort of 50 282 residents in the Lombardy Region (Italy) who were discharged with a diagnosis of ACS during 2011 to 2015 was followed up until 2018. Adherence to selected recommendations including drug therapies (DTs), outpatient controls, and rehabilitation, experienced during the first year after index discharge, was considered. Adherent and nonadherent cohort members were matched on high-dimensional propensity scores. Composite clinical outcomes (cardiovascular hospital admissions and all-cause mortality) and healthcare costs were assessed for a time horizon of 5 years. Cost-effectiveness profile of adherence to recommendations was measured through the incremental cost-effectiveness ratio, that is, the incremental cost for 1 day free from the composite clinical outcome. Results: Adherence to DTs, outpatient controls, and rehabilitation, respectively, regarded 39%, 81%, and 3% of cohort members. Compared with nonadherent patients, those adherent to DTs, outpatient controls, and rehabilitation had (1) a delay in the occurrence of the composite clinical outcome of 50, 43, and 73 days, respectively, and (2) lower (on average, €199 per year for DTs) and higher costs (€292 and €1024 for outpatient controls and rehabilitation). Cost-effectiveness profiles were better for patients with myocardial infarction than those with angina and for patients with more severe clinical complexity than those with milder conditions. Conclusions: Health-related and economic benefits are expected from improving adherence to international guidelines recommendations concerning outpatient treatments and monitoring of patients with ACS.

Published
2022

25. A novel workflow for advanced mapping of repolarization dispersion from endocardial unipolar electrograms in patients with coved-type brugada syndrome

Author

Latrofa, S, primary, Garibaldi, S, additional, Hartwig, S, additional, Panchetti, L, additional, Morelli, M S, additional, Martini, N, additional, Zaurino, N, additional, Mansi, G, additional, Mirizzi, G, additional, Startari, U, additional, Passino, C, additional, Emdin, M, additional, Piacenti, M, additional, Giannoni, A, additional, and Rossi, A, additional

Published
2023
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27. Impact of hospitalizations for bronchiolitis in preterm infants on long-term health care costs in Italy: a retrospective case-control study

Author

Roggeri DP, Roggeri A, Rossi E, Cataudella S, and Martini N

Subjects
Bronchiolitis, costs, preterm, hospitalizations, Medicine (General), R5-920, Therapeutics. Pharmacology, RM1-950
Abstract

Daniela Paola Roggeri,1 Alessandro Roggeri,1 Elisa Rossi,2 Salvatore Cataudella,2 Nello Martini,3 1ProCure Solutions, Nembro, Bergamo, 2CINECA Interuniversity Consortium, Bologna, 3Accademia Nazionale di Medicina, Rome, Italy Purpose: Bronchiolitis is an acute inflammatory injury of the bronchioles, and is the most frequent cause of hospitalization for lower respiratory tract infections in preterm infants. This was a retrospective, observational, case-control study conducted in Italy, based on administrative database analysis. The aim of this study was to evaluate differences in health care costs of preterm infants with and without early hospitalization for bronchiolitis. Patients and methods: Preterm infants born in the period between January 1, 2009 and December 31, 2010 and hospitalized for bronchiolitis in the first year of life were selected from the ARNO Observatory database and observed for the first 4 years of life. These preterm infants were compared (paired 1–3) with preterm infants who were not hospitalized for bronchiolitis in the first year of life and with similar characteristics. Only direct health care costs reimbursed by the Italian National Health Service were considered for this study (drugs, hospitalizations, and diagnostic/therapeutic procedures). Results: Of 40,823 newborns in the accrual period, 863 were preterm with no evidence of prophylaxis, and 22 preterm infants were hospitalized for bronchiolitis (cases) and paired with 62 controls. Overall, cases had 74% higher average cost per infant in the first 4 years of life than controls (18,624€ versus 10,189€, respectively). The major cost drivers were hospitalizations, accounting for >90% in both the populations. The increase in total yearly health care cost between cases and controls remained substantial even in the fourth year of life for all cost items. A relevant increase in hospitalizations and drug consumption linked to respiratory tract diseases was noted in infants hospitalized for bronchiolitis during the entire follow-up period. Conclusion: Preterm infants hospitalized for bronchiolitis in the first year of life were associated with increased resource consumption and costs throughout the entire period of observation; even in the fourth year, the difference versus paired controls was relevant. Keywords: bronchiolitis, cost, preterm, hospitalizations

Published
2016

36. Cost-effectiveness of the adherence with recommendations for clinical monitoring of patients with diabetes

Author

Corrao, G, Rea, F, Mancia, G, Perseghin, G, Merlino, L, Martini, N, Carbone, S, Carle, F, Bucci, A, Dajko, M, Arca, S, Bellentani, D, Bruno, V, Ceccolini, C, De Feo, A, Lispi, L, Mariniello, R, Masullo, M, Medici, F, Pisanti, P, Visca, M, Zanini, R, Di Fiandra, T, Magliocchetti, N, Romano, G, Cantarutti, A, Pugni, P, Davoli, M, Di Martino, M, Lallo, A, Vittori, P, Vuillermin, G, Bernardo, A, Fusciante, A, Belotti, L, De Palma, R, Di Felice, E, Chiandetti, R, Clagnan, E, Del Zotto, S, Di Lenarda, A, Mariotto, A, Prezza, M, Zanier, L, Fusco, D, Marinacci, C, Lora, A, Spazzafumo, L, Pizzi, S, Simiele, M, Massaro, G, Attolini, E, Lepore, V, Petrarolo, V, De Luca, G, Fantaci, G, Pollina Addario, S, Scondotto, S, Bellomo, F, Braga, M, Di Fabrizio, V, Forni, S, Francesconi, P, Profili, F, Avossa, F, Corradin, M, Vigna, S, Dondi, L, Pedrini, A, Piccinni, C, Cosentino, M, Marvulli, M, Maggioni, A, Corrao G., Rea F., Mancia G., Perseghin G., Merlino L., Martini N., Carbone S., Carle F., Bucci A., Dajko M., Arca S., Bellentani D., Bruno V., Ceccolini C., De Feo A., Lispi L., Mariniello R., Masullo M., Medici F., Pisanti P., Visca M., Zanini R., Di Fiandra T., Magliocchetti N., Romano G., Cantarutti A., Pugni P., Davoli M., Di Martino M., Lallo A., Vittori P., Vuillermin G., Bernardo A., Fusciante A., Belotti L., De Palma R., Di Felice E., Chiandetti R., Clagnan E., Del Zotto S., Di Lenarda A., Mariotto A., Prezza M., Zanier L., Fusco D., Marinacci C., Lora A., Spazzafumo L., Pizzi S., Simiele M., Massaro G., Attolini E., Lepore V., Petrarolo V., De Luca G., Fantaci G., Pollina Addario S., Scondotto S., Bellomo F., Braga M., Di Fabrizio V., Forni S., Francesconi P., Profili F., Avossa F., Corradin M., Vigna S., Dondi L., Pedrini A., Piccinni C., Cosentino M., Marvulli M. G., Maggioni A., Corrao, G, Rea, F, Mancia, G, Perseghin, G, Merlino, L, Martini, N, Carbone, S, Carle, F, Bucci, A, Dajko, M, Arca, S, Bellentani, D, Bruno, V, Ceccolini, C, De Feo, A, Lispi, L, Mariniello, R, Masullo, M, Medici, F, Pisanti, P, Visca, M, Zanini, R, Di Fiandra, T, Magliocchetti, N, Romano, G, Cantarutti, A, Pugni, P, Davoli, M, Di Martino, M, Lallo, A, Vittori, P, Vuillermin, G, Bernardo, A, Fusciante, A, Belotti, L, De Palma, R, Di Felice, E, Chiandetti, R, Clagnan, E, Del Zotto, S, Di Lenarda, A, Mariotto, A, Prezza, M, Zanier, L, Fusco, D, Marinacci, C, Lora, A, Spazzafumo, L, Pizzi, S, Simiele, M, Massaro, G, Attolini, E, Lepore, V, Petrarolo, V, De Luca, G, Fantaci, G, Pollina Addario, S, Scondotto, S, Bellomo, F, Braga, M, Di Fabrizio, V, Forni, S, Francesconi, P, Profili, F, Avossa, F, Corradin, M, Vigna, S, Dondi, L, Pedrini, A, Piccinni, C, Cosentino, M, Marvulli, M, Maggioni, A, Corrao G., Rea F., Mancia G., Perseghin G., Merlino L., Martini N., Carbone S., Carle F., Bucci A., Dajko M., Arca S., Bellentani D., Bruno V., Ceccolini C., De Feo A., Lispi L., Mariniello R., Masullo M., Medici F., Pisanti P., Visca M., Zanini R., Di Fiandra T., Magliocchetti N., Romano G., Cantarutti A., Pugni P., Davoli M., Di Martino M., Lallo A., Vittori P., Vuillermin G., Bernardo A., Fusciante A., Belotti L., De Palma R., Di Felice E., Chiandetti R., Clagnan E., Del Zotto S., Di Lenarda A., Mariotto A., Prezza M., Zanier L., Fusco D., Marinacci C., Lora A., Spazzafumo L., Pizzi S., Simiele M., Massaro G., Attolini E., Lepore V., Petrarolo V., De Luca G., Fantaci G., Pollina Addario S., Scondotto S., Bellomo F., Braga M., Di Fabrizio V., Forni S., Francesconi P., Profili F., Avossa F., Corradin M., Vigna S., Dondi L., Pedrini A., Piccinni C., Cosentino M., Marvulli M. G., and Maggioni A.

Abstract

Background and aims: To validate a set of indicators for monitoring the quality of care of patients with diabetes in ‘real-life’ practice through its relationship with measurable clinical outcomes and healthcare costs. Methods and results: A population-based cohort study was carried out by including the 20,635 patients, residents in the Lombardy Region (Italy), who in the year 2012 were newly taken-in-care for diabetes. Adherence with clinical recommendations (i.e., controls for glycated haemoglobin, lipid profile, urine albumin excretion and serum creatinine) was recorded during the first year after the patient was taken-in-care, and categorized according whether he/she complied with none or almost none (0 or 1), just some (2) or all or almost all (3 or 4) the recommendations, respectively denoted as poor, intermediate and high adherence. Short- and long-term complications of diabetes, and healthcare cost incurred by the National Health Service, were assessed during follow-up. Compared with patients with poor adherence, those with intermediate and high adherence respectively showed (i) a delay in outcome occurrence of 13 days (95% CI, −2 to 27) and 23 days (9–38), and (ii) a lower healthcare cost of 54 € and 77 €. In average, a gain of 18 Euros and 15 Euros for each day free from diabetic complication by increasing adherence respectively from poor to intermediate and from poor to high were observed. Conclusion: Close control of patients with diabetes through regular clinical examinations must be considered the cornerstone of national guidance, national audits, and quality improvement incentive schemes.

Published
2021

37. Ratio between left and right ventricular end-diastolic volumes and outcomes in patients with heart failure and preserved ejection fraction

Author

Aimo, A, primary, Teis, A, additional, Kasa, G, additional, Junca, G, additional, Lupon, J, additional, Domingo, M, additional, Ferrer, E, additional, Vallejo, N, additional, Cediel, G, additional, Codina, P, additional, Lopez-Ayerbe, J, additional, Martini, N, additional, Emdin, M, additional, Bayes-Genis, A, additional, and Delgado, V, additional

Published
2022
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38. Global warming, renal function and heart failure: a 20-year follow-up study

Author

Aimo, A, primary, Lupon, J, additional, Spitaleri, G, additional, Domingo, M, additional, Codina, P, additional, Santiago-Vacas, E, additional, Cediel, G, additional, Zamora, E, additional, Troya, M I, additional, Santesmases, J, additional, Romero-Gonzalez, G A, additional, Nunez, J, additional, Martini, N, additional, Emdin, M, additional, and Bayes-Genis, A, additional

Published
2022
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40. Potentially inappropriate medication use: the Beers' Criteria used among older adults with depressive symptoms

Author

Lee D, Martini N, Moyes S, Hayman K, Zolezzi M, and Kerse N

Subjects
Depression, depressive symptoms, inappropriate prescribing, older adults, Public aspects of medicine, RA1-1270
Abstract

INTRODUCTION: The ageing population means prescribing for chronic illnesses in older people is expected to rise. Comorbidities and compromised organ function may complicate prescribing and increase medication-related risks. Comorbid depression in older people is highly prevalent and complicates medication prescribing decisions. AIM: To determine the prevalence of potentially inappropriate medication use in a community-dwelling population of older adults with depressive symptoms. METHODS: The medications of 191 community-dwelling older people selected because of depressive symptoms for a randomised trial were reviewed and assessed using the modified version of the Beers' Criteria. The association between inappropriate medication use and various population characteristics was assessed using Chi-square statistics and logistic regression analyses. RESULTS: The mean age was 81 (±4.3) years and 59% were women. The median number of medications used was 6 (range 1-21 medications). The most commonly prescribed potentially inappropriate medications were amitriptyline, dextropropoxyphene, quinine and benzodiazepines. Almost half (49%) of the participants were prescribed at least one potentially inappropriate medication; 29% were considered to suffer significant depressive symptoms (Geriatric Depression Scale ≥5) and no differences were found in the number of inappropriate medications used between those with and without significant depressive symptoms (Chi-square 0.005 p=0.54). DISCUSSION: Potentially inappropriate medication use, as per the modified Beers' Criteria, is very common among community-dwelling older people with depressive symptoms. However, the utility of the Beers' Criteria is lessened by lack of clinical correlation. Ongoing research to examine outcomes related to apparent inappropriate medication use is needed.

Published
2013

42. Transmural voltage gradient dispersion and heterogeneity in brugada syndrome phenotype - a novel workflow for advanced mapping using endocardial unipolar electrograms J-point elevation

Author

Rossi, A, primary, Hartwig, V, additional, Morelli, M S, additional, Martini, N, additional, Zaurino, N, additional, Notarstefano, P, additional, Nesti, M, additional, Giannoni, A, additional, Mansi, G, additional, Mirizzi, G, additional, Panchetti, L, additional, Garibaldi, S, additional, Startari, U, additional, Piacenti, M, additional, and Vanello, N, additional

Published
2022
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45. Global Warming, Renal Function and Heart Failure Over 20 Years

Author

Aimo, A, Lupon, J, Spitaleri, G, Domingo, M, Codina, P, Santiago-Vacas, E, Cediel, G, Zamora, E, Troya, M, Santesmases, J, Romero-Gonzalez, GA, Nunez, J, Martini, N, Emdin, M, and Bayes-Genis, A

Subjects
Temperatures, History, Polymers and Plastics, Creatinine, Summer, Climate change, Business and International Management, Industrial and Manufacturing Engineering, Renal function
Abstract

Background: The impact of increasing temperatures on renal function in heart failure (HF) outpatients has never been specifically analyzed. Methods: We retrieved creatinine and estimated glomerular filtration rate (eGFR) values of all HF outpatients followed at a HF clinic and temperature data from 2002 to 2021. For each patient and each year we averaged values of creatinine, eGFR and monthly temperatures during summer and the rest of the year. Results: The study cohort included 2167 HF patients undergoing 25,865 elective visits, with a median of 14 visits for each patient (interquartile range 7-23). At the first visit, patients (70% men) had an age of 67 +/- 13 years, and a left ventricular ejection fraction of 35 +/- 14%. Creatinine was 1.25 +/- 0.51 mg/dL, and eGFR was 65 +/- 25 mL/ min/1.73 m(2). When pooling together all average values of creatinine and eGFR measured during summer or in the rest of the year, creatinine was significantly higher in summer (difference 0.04, 95% confidence interval [CI] 0.04 to 0.05, p < 0.001), and eGFR was slightly lower (difference -2.0, 95% CI-2.3 to-1.8, p < 0.001). Temperature rise during summer increased from 2002 to 2021. The absolute (delta) and percent (delta%) elevation in temperature during summer displayed independent associations with delta and delta% creatinine and eGFR after adjusting for age, sex, plasma creatinine, and HF therapies. Conclusions: The magnitude of temperature elevation during summer has increased over 20 years. This elevation correlates with the decline in renal function during summer. This might be an example of how global warming is affecting human health.

Published
2022
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50. What can real world evidence contribute to regulatory science in pre and post marketing setting?

Author

Martini, N, Sultana, J, Addis, ., Braga, M, Corrao, G, Campomori, A, Capuano, A, Gini, R, Mazzaglia, G, Patarnello, F, Petrini, C, Pierini, A, Pippo, L, Popoli, P, Russo, P, Scondotto, G, Trifirò, G, Martini, N., Sultana, J., Braga, M., Corrao, G., Campomori, A., Capuano, A., Gini, R., Mazzaglia, G., Patarnello, F., Petrini, C., Pierini, A., Pippo, L., Popoli, P., Russo, P., Scondotto, G., Trifirò, G., Martini, N, Sultana, J, Addis, ., Braga, M, Corrao, G, Campomori, A, Capuano, A, Gini, R, Mazzaglia, G, Patarnello, F, Petrini, C, Pierini, A, Pippo, L, Popoli, P, Russo, P, Scondotto, G, Trifirò, G, Martini, N., Sultana, J., Braga, M., Corrao, G., Campomori, A., Capuano, A., Gini, R., Mazzaglia, G., Patarnello, F., Petrini, C., Pierini, A., Pippo, L., Popoli, P., Russo, P., Scondotto, G., and Trifirò, G.

Published
2020

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