3,490 results on '"MARTELLUCCI, A."'
Search Results
2. Axon‐derived PACSIN1 binds to the Schwann cell survival receptor, LRP1, and transactivates TrkC to promote gliatrophic activities
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Martellucci, Stefano, Flütsch, Andreas, Carter, Mark, Norimoto, Masaki, Pizzo, Donald, Mantuano, Elisabetta, Sadri, Mahrou, Wang, Zixuan, Chillin‐Fuentes, Daisy, Rosenthal, Sara Brin, Azmoon, Pardis, Gonias, Steven L, and Campana, Wendy M
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Biomedical and Clinical Sciences ,Neurosciences ,Regenerative Medicine ,Physical Injury - Accidents and Adverse Effects ,Aetiology ,2.1 Biological and endogenous factors ,Neurological ,Animals ,Mice ,Rats ,Axons ,Cell Survival ,Cells ,Cultured ,Ligands ,Rats ,Sprague-Dawley ,Receptor Protein-Tyrosine Kinases ,Schwann Cells ,Humans ,Adaptor Proteins ,Signal Transducing ,Recombinant Proteins ,axon glia interaction ,cell signaling ,injury-repair ,LRP1 ,Schwann cells ,Neurology & Neurosurgery - Abstract
Schwann cells (SCs) undergo phenotypic transformation and then orchestrate nerve repair following PNS injury. The ligands and receptors that activate and sustain SC transformation remain incompletely understood. Proteins released by injured axons represent important candidates for activating the SC Repair Program. The low-density lipoprotein receptor-related protein-1 (LRP1) is acutely up-regulated in SCs in response to injury, activating c-Jun, and promoting SC survival. To identify novel LRP1 ligands released in PNS injury, we applied a discovery-based approach in which extracellular proteins in the injured nerve were captured using Fc-fusion proteins containing the ligand-binding motifs of LRP1 (CCR2 and CCR4). An intracellular neuron-specific protein, Protein Kinase C and Casein Kinase Substrate in Neurons (PACSIN1) was identified and validated as an LRP1 ligand. Recombinant PACSIN1 activated c-Jun and ERK1/2 in cultured SCs. Silencing Lrp1 or inhibiting the LRP1 cell-signaling co-receptor, the NMDA-R, blocked the effects of PACSIN1 on c-Jun and ERK1/2 phosphorylation. Intraneural injection of PACSIN1 into crush-injured sciatic nerves activated c-Jun in wild-type mice, but not in mice in which Lrp1 is conditionally deleted in SCs. Transcriptome profiling of SCs revealed that PACSIN1 mediates gene expression events consistent with transformation to the repair phenotype. PACSIN1 promoted SC migration and viability following the TNFα challenge. When Src family kinases were pharmacologically inhibited or the receptor tyrosine kinase, TrkC, was genetically silenced or pharmacologically inhibited, PACSIN1 failed to induce cell signaling and prevent SC death. Collectively, these studies demonstrate that PACSIN1 is a novel axon-derived LRP1 ligand that activates SC repair signaling by transactivating TrkC.
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- 2024
3. Evaluation and management of chronic anorectal and pelvic pain syndromes: Italian Society of Colorectal Surgery (SICCR) position statement
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Menconi, C., Marino, F., Bottini, C., La Greca, G., Gozzo, C., Losacco, L., Carlucci, D., Navarra, L., and Martellucci, J.
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- 2024
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4. Author Correction: A case study of impacts of an extreme weather system on the Mediterranean Sea circulation features: Medicane Apollo (2021)
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Menna, Milena, Martellucci, Riccardo, Reale, Marco, Cossarini, Gianpiero, Salon, Stefano, Notarstefano, Giulio, Mauri, Elena, Poulain, Pierre-Marie, Gallo, Antonella, and Solidoro, Cosimo
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- 2024
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5. Are we ready for "green surgery" to promote environmental sustainability in the operating room? Results from the WSES STAR investigation
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Dal Mas, Francesca, Cobianchi, Lorenzo, Piccolo, Daniele, Balch, Jeremy, Biancuzzi, Helena, Biffl, Walter L., Campostrini, Stefano, Cicuttin, Enrico, Coccolini, Federico, Damaskos, Dimitris, Filiberto, Amanda C., Filisetti, Claudia, Fraga, Gustavo, Frassini, Simone, Fugazzola, Paola, Hardcastle, Timothy, Kaafarani, Haytham M., Kluger, Yoran, Massaro, Maurizio, Martellucci, Jacopo, Moore, Ernest, Ruta, Federico, Sartelli, Massimo, Stahel, Philip F., Velmahos, George, Weber, Dieter G., Catena, Fausto, Loftus, Tyler J., and Ansaloni, Luca
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- 2024
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6. Sacral Neuromodulation for defecation disorders after non oncologic pelvic surgery
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Martellucci, Jacopo, Annicchiarico, Alfredo, Scheiterle, Maximilian, Trompetto, Mario, and Prosperi, Paolo
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- 2024
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7. Fever and dyspnea after anti-Covid-19 vaccination: a challenging diagnosis
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Palladino, Mariangela, Del Vecchio, Martina, Farroni, Simone, Martellucci, Ottavio, Gigante, Antonietta, Alessandri, Cristiano, and Muscaritoli, Maurizio
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- 2024
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8. Effectiveness of tailored talks between a cancer screening specialist and general practitioners to improve the uptake of colorectal cancer screening in Ancona (Italy) during the pandemic period
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Cecilia Acuti Martellucci, Giusi Giacomini, Maria Elena Flacco, Lamberto Manzoli, Margherita Morettini, Mosè Martellucci, Sara Rosati, Silvia Bizzarri, Matthew Palmer, Lidia Pascucci, Marco Uncini, and Francesca Pasqualini
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Colorectal cancer ,cancer screening ,general practice ,Italy ,Medicine (General) ,R5-920 - Abstract
AbstractBackground Colorectal cancer (CRC) screening uptake in many countries has been low and further impacted by the COVID-19 pandemic. General Practitioners (GPs) are key facilitators, however research on their impact on organised CRC screening is still limited.Objectives To evaluate the effectiveness of tailored talks with GPs to increase population uptake of the long-established CRC screening programme in Ancona province, Italy.Methods In this prospective cohort study, one-to-one tailored talks were organised in January 2020 between the GPs of one county of the province (with GPs from other counties as controls) and the screening programme physician-in-chief to discuss the deployment and effectiveness of organised screening. Data was extracted from the National Healthcare System datasets and linear regression was used to assess the potential predictors of CRC screening uptake.Results The mean CRC screening uptake remained stable from 39.9% in 2018–19 to 40.8% in 2020–21 in the 22 GPs of the intervention county, whereas it statistically significantly decreased from 38.7% to 34.7% in the 232 control GPs. In multivariate analyses, belonging to the intervention county was associated with an improved uptake compared to the control counties (+5.1%; 95% Confidence Intervals – CI: 2.0%; 8.1%).Conclusion Persons cared for by GPs who received a tailored talk with a cancer screening specialist avoided a drop in CRC screening adherence, which characterised all other Italian screening programmes during the COVID-19 emergency. If future randomised trials confirm the impact of tailored talks, they may be incorporated into existing strategies to improve population CRC screening uptake.
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- 2024
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9. The intricate relationship between obesity, type 2 diabetes and female breast cancer: A retrospective study of 335 women
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Ilaria Milani, Chiara Gaita, Gloria Guarisco, Marianna Chinucci, Roberta Parisella, Silvia Piroli, Eleonora Bruno, Annunziata Martellucci, Elena De Falco, Fabio Ricci, Antonella Calogero, Frida Leonetti, and Danila Capoccia
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breast cancer ,histology ,menopause ,obesity ,type 2 diabetes ,Internal medicine ,RC31-1245 - Abstract
Abstract Background Type 2 diabetes (T2D) is a risk factor for female breast cancer (FBC). Obesity has also been associated with FBC, also depending on menopausal status. This study aimed to evaluate the impact of obesity and T2D on the development, aggressiveness, and invasiveness of FBC. Methods Demographic, clinical, and histopathological data from 335 women with FBC were collected, and analyzed according to weight category (102 normal weight, 117 overweight, and 116 living with obesity) and the presence/absence of T2D. Results Age at oncologic diagnosis was not statistically significantly different for body weight; women with overweight or obesity were more likely to have an oncologic diagnosis after menopause than normal weight (p 20%). This study highlights the importance of prevention in all women, with early screening, and adequate nutritional programs.
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- 2024
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10. Horizontal Lidar Environmental Monitoring: Preliminary Results on Tropospheric Backscattering Evaluation and Atmospheric Dispersed Particulate Characterisation
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Rutigliano, Novella, Martellucci, Luca, Gaudio, Pasquale, Ceccarelli, Marco, Series Editor, Corves, Burkhard, Advisory Editor, Glazunov, Victor, Advisory Editor, Hernández, Alfonso, Advisory Editor, Huang, Tian, Advisory Editor, Jauregui Correa, Juan Carlos, Advisory Editor, Takeda, Yukio, Advisory Editor, Agrawal, Sunil K., Advisory Editor, Montanari, Roberto, editor, Richetta, Maria, editor, Febbi, Massimiliano, editor, and Staderini, Enrico Maria, editor
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- 2024
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11. Posterior Semicircular Canal Dehiscence with Vestibulo-Ocular Reflex Reduction for the Affected Canal at the Video-Head Impulse Test: Considerations to Pathomechanisms
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Andrea Castellucci, Georges Dumas, Sawsan M. Abuzaid, Enrico Armato, Salvatore Martellucci, Pasquale Malara, Mohamad Alfarghal, Rosanna Rita Ruberto, Pasquale Brizzi, Angelo Ghidini, Francesco Comacchio, and Sébastien Schmerber
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posterior canal dehiscence ,third mobile window ,horizontal canal dehiscence ,video-head impulse test ,vestibular evoked myogenic potentials ,conductive hearing loss ,Otorhinolaryngology ,RF1-547 - Abstract
Posterior semicircular canal dehiscence (PSCD) has been demonstrated to result in a third mobile window mechanism (TMWM) in the inner ear similar to superior semicircular canal dehiscence (SSCD). Typical clinical and instrumental features of TMWM, including low-frequency conductive hearing loss (CHL), autophony, pulsatile tinnitus, sound/pressure-induced vertigo and enhanced vestibular-evoked myogenic potentials, have been widely described in cases with PSCD. Nevertheless, video-head impulse test (vHIT) results have been poorly investigated. Here, we present six patients with PSCD presenting with a clinical scenario consistent with a TMWM and an impaired vestibulo-ocular reflex (VOR) for the affected canal on vHIT. In two cases, an additional dehiscence between the facial nerve and the horizontal semicircular canal (HSC) was detected, leading to a concurrent VOR impairment for the HSC. While in SSCD, a VOR gain reduction could be ascribed to a spontaneous “auto-plugging” process due to a dural prolapse into the canal, the same pathomechanism is difficult to conceive in PSCD due to a different anatomical position, making a dural herniation less likely. Alternative putative pathomechanisms are discussed, including an endolymphatic flow dissipation during head impulses as already hypothesized in SSCD. The association of symptoms/signs consistent with TMWM and a reduced VOR gain for the posterior canal might address the diagnosis toward PSCD.
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- 2024
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12. Lipid rafts mediate multilineage differentiation of human dental pulp-derived stem cells (DPSCs)
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Santilli, Francesca, Fabrizi, Jessica, Martellucci, Stefano, Santacroce, Costantino, Iorio, Egidio, Pisanu, Maria Elena, Chirico, Mattea, Lancia, Loreto, Pulcini, Fanny, Manganelli, Valeria, Sorice, Maurizio, Delle Monache, Simona, and Mattei, Vincenzo
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Biochemistry and Cell Biology ,Biomedical and Clinical Sciences ,Biological Sciences ,Stem Cell Research ,Prevention ,Dental/Oral and Craniofacial Disease ,Underpinning research ,1.1 Normal biological development and functioning ,DPSCs ,lipid rafts ,gangliosides ,osteogenic ,chondrogenic and adipogenic differentiation ,multilineage differentiation ,mesenchymal stem cells ,dental pulp stem cells ,Biological sciences ,Biomedical and clinical sciences - Abstract
Cell outer membranes contain glycosphingolipids and protein receptors, which are integrated into glycoprotein domains, known as lipid rafts, which are involved in a variety of cellular processes, including receptor-mediated signal transduction and cellular differentiation process. In this study, we analyzed the lipidic composition of human Dental Pulp-Derived Stem Cells (DPSCs), and the role of lipid rafts during the multilineage differentiation process. The relative quantification of lipid metabolites in the organic fraction of DPSCs, performed by Nuclear Magnetic Resonance (NMR) spectroscopy, showed that mono-unsaturated fatty acids (MUFAs) were the most representative species in the total pool of acyl chains, compared to polyunsatured fatty acids (PUFAs). In addition, the stimulation of DPSCs with different culture media induces a multilineage differentiation process, determining changes in the gangliosides pattern. To understand the functional role of lipid rafts during multilineage differentiation, DPSCs were pretreated with a typical lipid raft affecting agent (MβCD). Subsequently, DPSCs were inducted to differentiate into osteoblast, chondroblast and adipoblast cells with specific media. We observed that raft-affecting agent MβCD prevented AKT activation and the expression of lineage-specific mRNA such as OSX, PPARγ2, and SOX9 during multilineage differentiation. Moreover, this compound significantly prevented the tri-lineage differentiation induced by specific stimuli, indicating that lipid raft integrity is essential for DPSCs differentiation. These results suggest that lipid rafts alteration may affect the signaling pathway activated, preventing multilineage differentiation.
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- 2023
13. Correction and harmonization of dissolved oxygen data from autonomous platforms in the South Adriatic Pit (Mediterranean Sea)
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Riccardo Gerin, Riccardo Martellucci, Gilda Savonitto, Giulio Notarstefano, Cinzia Comici, Nevio Medeot, Rade Garić, Mirna Batistić, Carlotta Dentico, Vanessa Cardin, Piero Zuppelli, Antonio Bussani, Massimo Pacciaroni, and Elena Mauri
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Argo float ,Glider ,Winkler method ,dissolved oxygen sensor drift ,data validation ,Science ,General. Including nature conservation, geographical distribution ,QH1-199.5 - Abstract
Dissolved oxygen (DO) is one of the most important drivers of ocean biogeochemical cycles and marine life, and in many areas its concentration has declined due to climate change. In recent decades, a growing number of autonomous oceanographic platforms has been equipped with sensors for direct in situ measurements of oxygen levels. However, to ensure high quality and comparable data, these observations need to be validated or, if necessary, corrected. In this paper, we compiled all the available DO data collected by Argo floats and gliders in the South Adriatic Pit (Mediterranean Sea) between 2014 and 2020. This dataset includes data for which it was not possible to apply conventional quality-control methods. Therefore, we had to apply tailored procedures based on well-established best practices for correction. The aim is to showcase how these tailored procedures allowed us to achieve the best possible quality of data and generate consistent datasets. The drift of the glider DO sensors related to storage was also estimated. The described procedure could be useful in similar cases where the conventional methods are not viable, thus making available potentially useful data.
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- 2024
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14. Recent changes of the dissolved oxygen distribution in the deep convection cell of the southern Adriatic Sea
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Martellucci, R., Menna, M., Mauri, E., Pirro, A., Gerin, R., Paladini de Mendoza, F., Garić, R., Batistić, M., di Biagio, V., Giordano, P., Langone, L., Miserocchi, S., Gallo, A., Notarstefano, G., Savonitto, G., Bussani, A., Pacciaroni, M., Zuppelli, P., and Poulain, P.-M.
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- 2024
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15. Are we ready for 'green surgery' to promote environmental sustainability in the operating room? Results from the WSES STAR investigation
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Francesca Dal Mas, Lorenzo Cobianchi, Daniele Piccolo, Jeremy Balch, Helena Biancuzzi, Walter L. Biffl, Stefano Campostrini, Enrico Cicuttin, Federico Coccolini, Dimitris Damaskos, Amanda C. Filiberto, Claudia Filisetti, Gustavo Fraga, Simone Frassini, Paola Fugazzola, Timothy Hardcastle, Haytham M. Kaafarani, Yoran Kluger, Maurizio Massaro, Jacopo Martellucci, Ernest Moore, Federico Ruta, Massimo Sartelli, Philip F. Stahel, George Velmahos, Dieter G. Weber, Fausto Catena, Tyler J. Loftus, Luca Ansaloni, and the STAR Study Group
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Environmental Sustainability ,Sustainability ,Trauma and emergency surgery ,survey ,Green ,Surgery ,RD1-811 ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Abstract Background The importance of environmental sustainability is acknowledged in all sectors, including healthcare. To meet the United Nations Sustainable Development Goals 2030 Agenda, healthcare will need a paradigm shift toward more environmentally sustainable practices that will also impact clinical decision-making. The study investigates trauma and emergency surgeons’ perception, acceptance, and employment of environmentally friendly habits. Methods An online survey based on the most recent literature regarding environmental sustainability in healthcare and surgery was created by a multidisciplinary committee and endorsed by the World Society of Emergency Surgery (WSES). The survey was advertised to the 917 WSES members through the society’s website and Twitter/X profile. Results 450 surgeons from 55 countries participated in the survey. Results underline both a generally positive attitude toward environmental sustainability but also a lack of knowledge about several concepts and practices, especially concerning the potential contribution to patient care. Discussion The topic of environmental sustainability in healthcare and surgery is still in its infancy. There is a clear lack of salient guidance and knowledge, and there is a critical need for governments, institutions, health agencies, and scientific societies to promote, disseminate, and report environmentally friendly initiatives and their potential impacts while employing an interdisciplinary approach.
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- 2024
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16. Laser technology in proctological diseases: is it really the wave of the future?
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Solari, Stefano, Martellucci, Jacopo, Annicchiarico, Alfredo, Scheiterle, Maximilian, Bergamini, Carlo, and Prosperi, Paolo
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- 2023
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17. Low-Frequency Air–Bone Gap and Pulsatile Tinnitus Due to a Dural Arteriovenous Fistula: Considerations upon Possible Pathomechanisms and Literature Review
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Andrea Tozzi, Andrea Castellucci, Giuseppe Ferrulli, Salvatore Martellucci, Pasquale Malara, Cristina Brandolini, Enrico Armato, and Angelo Ghidini
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conductive hearing loss ,air–bone gap ,pulsatile tinnitus ,dural arteriovenous fistula ,inner ear fluids ,venous intracranial hypertension ,Otorhinolaryngology ,RF1-547 - Abstract
Low-frequency air–bone gap (ABG) associated with pulsatile tinnitus (PT) and normal impedance audiometry represents a common finding in patients with third window syndromes. Other inner disorders, including Meniere’s disease (MD), perilymphatic fistula and intralabyrinthine schwannoma, might sometimes result in a similar scenario. On the other hand, PT is frequently associated with dural arteriovenous fistula (DAVF), while conductive hearing loss (CHL) is extremely rare in this clinical setting. A 47-year-old patient was referred to our center with progressive left-sided PT alongside ipsilateral fullness and hearing loss. She also experienced headache and dizziness. Otoscopy and video-oculographic examination were unremarkable. Conversely, a detailed instrumental audio-vestibular assessment revealed low-frequency CHL with normal impedance audiometry, slight left-sided caloric weakness, slightly impaired vestibular-evoked myogenic potentials on the left and normal results on the video-head impulse test, consistent with an MD-like instrumental profile. Gadolinium-enhanced brain MRI revealed an early enhancement of the left transverse sinus, consistent with a left DAVF between the left occipital artery and the transverse sinus, which was then confirmed by angiography. A trans-arterial embolization with Onyx glue was performed, resulting in a complete recession of the symptoms. Post-operatively, the low-frequency ABG disappeared, supporting the possible role of venous intracranial hypertension and abnormal pressure of inner ear fluids in the onset of symptoms and offering new insights into the pathomechanism of inner ear CHL.
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- 2023
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18. Abstract 6307: The botanical drug PBI-05204, a supercritical CO₂ extract of Nerium oleander, augments the antitumor efficacy of radiotherapy in treatment of human glioblastoma
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Colapietro, Alessandro, Yang, Peiying, Rosetti, Alessandra, Mancini, Andrea, Vital, Flora, Martellucci, Stefano, Marampon, Francesco, Mattei, Vincenzo, Gravina, Giovanni Luca, Newman, Robert, and Festuccia, Claudio
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Complementary and Integrative Health ,Biotechnology ,Rare Diseases ,Neurosciences ,Cancer ,Brain Disorders ,Genetics ,Brain Cancer ,Development of treatments and therapeutic interventions ,5.1 Pharmaceuticals ,Good Health and Well Being ,Oncology and Carcinogenesis ,Oncology & Carcinogenesis - Abstract
Abstract Glioblastoma multiforme (GBM) is the most common as well as one of the most malignant types of brain cancer. Despite progress in development of novel therapies for the treatment of GBM, it remains largely incurable with a poor prognosis and a very low life expectancy. Recent studies have shown that oleandrin, a unique cardiac glycoside from Nerium oleander, as well as defined extract (PBI-05204) that contains this molecule, inhibit growth of human glioblastoma, and modulate glioblastoma patient-derived stem cell-renewal properties. The present study aimed to investigate the radiosensitization of PBI-05204 in glioblastoma using both in vitro and in vivo cancer models as well as to explore the potential mechanism of actions in GBM. The radiosensitizing effect of PBI-05204 was assessed against human GBM U87MG, U251, T98G and A172 cell lines as well as their relevant xenograft and orthotopic models. The induction of apoptosis, DNA damage and repair of DNA double strand breaks were assessed with determination of caspase 3 and 9 protein expression, DNA laddering, protein expression of rH2AX, Ku70, DNA-PKcs, and RAD51 as well as a Comet Assay. PBI-05204 treatment leads to an increased in vitro sensitivity of GBM cells, including U87MG, U251, T98G and A172 cells, to radiotherapy (RT) in which the main mechanisms are the transition from autophagy to apoptosis and enhanced DNA damage evidenced by increased expression of γH2AX. Additionally, relative increased expression of Ku70, DNA-PKcs and RAD51 due to RT were reduced by PBI-05204 in U87MG and U251 cells, suggesting PBI-05204 lessened RT mediated DNA repair. PBI-05204 significantly enhanced the RT mediated inhibition of tumor growth by 4.7-, 2.1- and 2.2-fold in U87MG, U251 and T98G xenograft models, respectively. The combination of RT and PBI-05204 showed a significantly enhancement of disease-free survival to 103.0 ± 63.2 days compared to the control group (p < 0.001) which was 3-fold longer than that of RT only group. Collectively, these results reveal that PBI-05204 enhances antitumor activity of RT in preclinical/murine models of human GBM. Given the fact that PBI-05204 has already been examined in Phase I and II clinical trials for cancer patients, its efficacy when combined with standard-of-care radiotherapy regimens in GBM should be explored in future clinical trials of this difficult to treat brain cancer. Citation Format: Alessandro Colapietro, Peiying Yang, Alessandra Rosetti, Andrea Mancini, Flora Vital, Stefano Martellucci, Francesco Marampon, Vincenzo Mattei, Giovanni Luca Gravina, Robert Newman, Claudio Festuccia. The botanical drug PBI-05204, a supercritical CO₂ extract of Nerium oleander, augments the antitumor efficacy of radiotherapy in treatment of human glioblastoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 6307.
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- 2022
19. Shared Decision-Making and Coproduction in Surgery: The Patient Is the Cure
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Cobianchi, Lorenzo, Dal Mas, Francesca, Martellucci, Jacopo, Ruta, Federico, Fugazzola, Paola, Frassini, Simone, Ansaloni, Luca, Marini, Maria Giulia, Series Editor, McFarland, Jonathan, Series Editor, Boyce-Tillman, June, Editorial Board Member, Delorenzo, Christian, Editorial Board Member, Farkas, Carol-Ann, Editorial Board Member, Frey, Marco, Editorial Board Member, Messner, Angelika, Editorial Board Member, Vagnarelli, Federica, Editorial Board Member, Varsou, Ourania, Editorial Board Member, Vickers, Neil, Editorial Board Member, Martellucci, Jacopo, editor, and Dal Mas, Francesca, editor
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- 2023
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20. Towards a Green Surgery: The Problem of Costs and Sustainability in Surgical Practice
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Scheiterle, Maximilian, Martellucci, Jacopo, Dal Mas, Francesca, Tomaiuolo, Matteo, Prosperi, Paolo, Marini, Maria Giulia, Series Editor, McFarland, Jonathan, Series Editor, Boyce-Tillman, June, Editorial Board Member, Delorenzo, Christian, Editorial Board Member, Farkas, Carol-Ann, Editorial Board Member, Frey, Marco, Editorial Board Member, Messner, Angelika, Editorial Board Member, Vagnarelli, Federica, Editorial Board Member, Varsou, Ourania, Editorial Board Member, Vickers, Neil, Editorial Board Member, Martellucci, Jacopo, editor, and Dal Mas, Francesca, editor
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- 2023
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21. Translating Knowledge in Surgery
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Dal Mas, Francesca, Cobianchi, Lorenzo, Cicuttin, Enrico, Fugazzola, Paola, Frassini, Simone, Ansaloni, Luca, Catena, Fausto, Martellucci, Jacopo, Marini, Maria Giulia, Series Editor, McFarland, Jonathan, Series Editor, Boyce-Tillman, June, Editorial Board Member, Delorenzo, Christian, Editorial Board Member, Farkas, Carol-Ann, Editorial Board Member, Frey, Marco, Editorial Board Member, Messner, Angelika, Editorial Board Member, Vagnarelli, Federica, Editorial Board Member, Varsou, Ourania, Editorial Board Member, Vickers, Neil, Editorial Board Member, Martellucci, Jacopo, editor, and Dal Mas, Francesca, editor
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- 2023
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22. New Surgical Leaders Built on Non-technical Skills: Communication, Team Dynamics, and Leadership
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Scheiterle, Maximilian, Martellucci, Jacopo, Dal Mas, Francesca, Marini, Maria Giulia, Series Editor, McFarland, Jonathan, Series Editor, Boyce-Tillman, June, Editorial Board Member, Delorenzo, Christian, Editorial Board Member, Farkas, Carol-Ann, Editorial Board Member, Frey, Marco, Editorial Board Member, Messner, Angelika, Editorial Board Member, Vagnarelli, Federica, Editorial Board Member, Varsou, Ourania, Editorial Board Member, Vickers, Neil, Editorial Board Member, Martellucci, Jacopo, editor, and Dal Mas, Francesca, editor
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- 2023
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23. The Bionic Man: From Neuromodulation to Visual Prosthesis
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Martellucci, Jacopo, Dal Mas, Francesca, Marini, Maria Giulia, Series Editor, McFarland, Jonathan, Series Editor, Boyce-Tillman, June, Editorial Board Member, Delorenzo, Christian, Editorial Board Member, Farkas, Carol-Ann, Editorial Board Member, Frey, Marco, Editorial Board Member, Messner, Angelika, Editorial Board Member, Vagnarelli, Federica, Editorial Board Member, Varsou, Ourania, Editorial Board Member, Vickers, Neil, Editorial Board Member, Martellucci, Jacopo, editor, and Dal Mas, Francesca, editor
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- 2023
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24. Dr Surgeon & Mr. Manager: The Hybrid Role of Surgeons
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Biancuzzi, Helena, Dal Mas, Francesca, Martellucci, Jacopo, Marini, Maria Giulia, Series Editor, McFarland, Jonathan, Series Editor, Boyce-Tillman, June, Editorial Board Member, Delorenzo, Christian, Editorial Board Member, Farkas, Carol-Ann, Editorial Board Member, Frey, Marco, Editorial Board Member, Messner, Angelika, Editorial Board Member, Vagnarelli, Federica, Editorial Board Member, Varsou, Ourania, Editorial Board Member, Vickers, Neil, Editorial Board Member, Martellucci, Jacopo, editor, and Dal Mas, Francesca, editor
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- 2023
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25. When Surgery Meets the Metaverse
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Martellucci, Jacopo, Dal Mas, Francesca, Pantalone, Desirè, Bergamini, Carlo, Prosperi, Paolo, Marini, Maria Giulia, Series Editor, McFarland, Jonathan, Series Editor, Boyce-Tillman, June, Editorial Board Member, Delorenzo, Christian, Editorial Board Member, Farkas, Carol-Ann, Editorial Board Member, Frey, Marco, Editorial Board Member, Messner, Angelika, Editorial Board Member, Vagnarelli, Federica, Editorial Board Member, Varsou, Ourania, Editorial Board Member, Vickers, Neil, Editorial Board Member, Martellucci, Jacopo, editor, and Dal Mas, Francesca, editor
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- 2023
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26. How to Create a Surgeon: The Surgical Leaders of Tomorrow
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Martellucci, Jacopo, Dal Mas, Francesca, Marini, Maria Giulia, Series Editor, McFarland, Jonathan, Series Editor, Boyce-Tillman, June, Editorial Board Member, Delorenzo, Christian, Editorial Board Member, Farkas, Carol-Ann, Editorial Board Member, Frey, Marco, Editorial Board Member, Messner, Angelika, Editorial Board Member, Vagnarelli, Federica, Editorial Board Member, Varsou, Ourania, Editorial Board Member, Vickers, Neil, Editorial Board Member, Martellucci, Jacopo, editor, and Dal Mas, Francesca, editor
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- 2023
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27. How to Create a Surgeon: History of Surgical Training
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Lippi, Donatella, Martellucci, Jacopo, Marini, Maria Giulia, Series Editor, McFarland, Jonathan, Series Editor, Boyce-Tillman, June, Editorial Board Member, Delorenzo, Christian, Editorial Board Member, Farkas, Carol-Ann, Editorial Board Member, Frey, Marco, Editorial Board Member, Messner, Angelika, Editorial Board Member, Vagnarelli, Federica, Editorial Board Member, Varsou, Ourania, Editorial Board Member, Vickers, Neil, Editorial Board Member, Martellucci, Jacopo, editor, and Dal Mas, Francesca, editor
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- 2023
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28. Access to and quality of elective care: a prospective cohort study using hernia surgery as a tracer condition in 83 countries
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Dönmez, A Eylül, Goswami, Aakansha Giri, Raheja, Aashna, Bhadani, Aayush, El Kady, Abd Elrahman Safwat, Alniemi, Abdalaziz, Awad, Abdalkarim, Aladl, Abdalla, Younis, Abdalla, Alwali, Abdallah, Khalil, Abdallah, Mansour, Abdallah, Elkhouly, Abdallah Mohamed, Rashad Temerik, Abdallah, Hasan, Abdallatef, Chied, Abdelhafid, Abdraba, Abdelhamid, Hrora, Abdelmalek, Abdelshafi, Abdelrahman, Alwali, Abdelrahman, Maraqa, Abdelrahman, Ghaffar, Abdul, Chekfa, Abdul Jabar, Al Balushi, Abdul Majeed, Quddus, Abdul, Hammadieh, Abdul Rahman, Muntaka, Abdul-Jalilu Mohammed, Asekun, Abdulazeez, Alshahrani, Abdulaziz, Jowharji, Abdulaziz, Alshukre, Abdulbaset, Khair Etareig, Abdulhafid, Abubakar Abdulkarim, Abdulhafiz, Ashiru, Abdulhafiz, Alailesh, Abdulhamid, Al-Mallah, Abdullah, Baydoun, Abdullah, Chaudhry, Abdullah, Askin, Abdullah Emre, Almutairi, Abdulmjeed, Belkhair, Abdulmunem, Abdllah, Abdulrahman, Alhammali, Abdulrahman, Basalim, Abdulrahman, Abouelnagah, Abdulrahman Galal Mohamed Mostafa, Ghazal, Abdulrahman, Mohammed, Abdulrahman, Qasem, Abdulrahman, Anadani, Abdulrazak, Jimoh, Abdulrazaq, Lawal, Abdulrazzaq Oluwagbemiga, Khaity, Abdulrhman, Lawal, Abdulwahab, Elzoubi, Abdurrahim Esseid, Sheshe, Abdurrahman Abba, Cetişli, Abdurrahman Furkan, Oyedele, Abeeb, Aljahdali, Abeer, Aboelnasr, Abeer Gamal Elsyed, Demessie, Abel, Bhargava, Abhilasha, Sonkar, Abhinav Arun, Bavaharan, Abhirame, Khan, Abid, Campbell, Abigail, Oyelekan, Abimbola Adeola Akintunde, Okunlola, Abiodun Idowu, Ojewuyi, Abiodun, Ekerin, Abiola, Saleh, Abobakr, Khairy, Abouelatta, Muthunayagam, Abraham Benjamin, Botha, Abraham, Teshome Sahilemariam, Abraham, Nawawi, Abrar, Muhammad, Abubakar Bala, Dahiru, Abubakar, Yahaya, Abubakar, Abdelmalik, Abubaker, Anuar, Abul Akmal Arif, Ousseini, Adakal, Leon -Del- Angel, Adalberto, Frankel, Adam, Gyedu, Adam, Lim, Adam, Lukáč, Adam, Peckham-Cooper, Adam, Sabbah, Adam, Varga, Adam, Sanou, Adama, Issaka, Adamu, Ningi, Adamu, Yeshitila, Addis, Yingess, Addisu, Olugbami, Adebayo, Moses, Damola-Okesiji, Adebola, Lawal, Adedayo, Ojo, Adedoyin, Hashmi, Adeel, Fakoya, Adegbolahan, Ishola, Adegoke, Abiodun, Adekunle, Ajayi, Adekunle, Mouffokes, Adel, Bonelli, Adele, Adekoya, Adeleke, Akeem Aderogba, Adeleke, Özcan, Adem, Ayoade, Ademidun, Adeyeye, Ademola, Agbaje, Ademola, Talabi, Ademola, Ademuyiwa, Adesoji, Adewumiya, Adesoji, Ademuyiwa, Adesoji O, Aderounmu, Adewale, Adisa, Adewale, Oke, Adewale, Ragab, Adham, Alzadjali, Adil, Baksi, Aditya, Jayapalan, Aditya, Md Yunos, Adnan, Pisanu, Adolfo, Salazar, Adolfo, Salinas Barragan, Adrian Alberto, Fox, Adrian, Stollberg, Adrian, Franco, Adriana, Neves, Adriana, Vricheva, Adriana, Hodonou, Adrien Montcho, Aghayeva, Afag, Liaquat, Affifa, Alsultan, Afnan, Morad, Afnan, Kalidis, Afroditi Angella, Gkouniaroudi, Agathi, Karakosta, Agathi, Lovi, Agbenya, Yevide, Agossou Barthélémy, Duro, Agustin, Rodriguez Gonzalez, Agustin, Tariq, Ahbala, Abaidalla, Ahmad, Abuhammad, Ahmad, Abuhantash, Ahmad, Mansour, Ahmad Adel, Ahmad Zaidi, Ahmad Al Hafeez, Alahmad Alismael, Ahmad, Alayed, Ahmad, Alfarwan, Ahmad, Alhaj, Ahmad, Ali, Ahmad, Alroobi, Ahmad, Alsheikh, Ahmad, Alusef, Ahmad, Alzu'Bi, Ahmad, Kayali, Ahmad Amir, Bouhuwaish, Ahmad, Doghaim, Ahmad, El-Sherbiney, Ahmad, Ghazal, Ahmad, Ramly, Ahmad Nasir, Raza, Ahmad, Qureshi, Ahmad Uzair, Arnaout, Ahmad Yamen, Abdelhamid, Ahmed, Abuthaher, Ahmed, Adel, Ahmed, Ahmayda, Ahmed, Al-Mouahhed, Ahmed, Alagha, Ahmed, Albalawi, Ahmed, Albhaisi, Ahmed, Alrifaee, Ahmed, Azam, Ahmed, Barakat, Ahmed, Al-Hajjaj, Ahmed Basim Abed, Dawoud, Ahmed, El Shamarka, Ahmed, El-Bastwesy, Ahmed, Elghrieb, Ahmed, Elkhalifa, Ahmed, Elmosalamy, Ahmed, Elshazli Mahmoud, Ahmed, Montaser, Ahmed G., Gbeadese, Ahmed, Haty, Ahmed, K. Ali, Ahmed, Awad, Ahmed K., Kedwany, Ahmed, Khalleefah, Ahmed, Abbas, Ahmed M., Allam, Ahmed M., Maher, Ahmed, Elsayed, Ahmed Mohamed, Mohamed Ibrahim Mohamed, Ahmed, Mostafa, Ahmed, Nabil, Ahmed, Nada, Ahmed, Ragheb, Ahmed, Abdelrahman, Ahmed Saber Mohamed, Sabry, Ahmed, Sakr, Ahmed, Elkhodary, Ahmed Salah, Shaheen, Ahmed, Ammar, Ahmed Siddique, Hameed, Ahmer, Akmercan, Ahmet, Aslan, Ahmet, Barcin, Ahmet, Ciftci, Ahmet Burak, Bozkurt, Ahmet Çağlar, Sarı, Ahmet Can, Yaşar, Ahmet Can, Develioğlu, Ahmet, Öztürk, Ahmet Mücteba, Sanli, Ahmet Necati, Rencuzogullari, Ahmet, Yildiz, Ahmet, Kaan, Ahmet Zahit, Toi, Ahouefa Chourika Sakinath, Aljamoudi, Aida, Cheung, Aiden Chak Kei, Gkoutoula, Aikaterini, Kalogeropoulou, Aikaterini, Sarafi, Aikaterini, Abo Al Shamat, Aiman, Sanon, Aimé Serge Titianma, Sanon, Aimée Florence, Hiller, Aimée, Costas-Chavarri, Ainhoa, Lombardero, Ainhoa, Fraile, Ainoa, Bojazyah, Aisha, Kamal, Aisha, Gill, Aisling, Hada, Aïssatou, Gulla, Aiste, Mačiulaitytė, Aistė, Sukumar, Aiswarya, Landaluce-Olavarria, Aitor, Sainz Lete, Aitor, Pal, Ajay Kumar, Malik, Ajaz Ahmad, Horiguchi, Akihiko, Kocaay, Akin Firat, Akinkuolie, Akinbolaji, Olabode, Akingunloye, Fadipe, Akinniyi, Akinmade, Akinola, Darkwa Boateng, Akosua, Appiah-Kubi, Akosua Yeboaa, Alkaseek, Akram, Kadamani Abiyomaa, Akram, Anand, Akshay, Oppong, Akua, Opoku-Agyapong, Akwasi, Asharaf, Al Ameen, Ahmed, Al Samoul, Andani, Al-Hassan Dasana, Alkharusi, Al-Salt, Abd Elsattar, Alaa, Alragheai, Alaa, Alsalahat, Alaa Atta, Hawarah, Alaa, Aldirani, Alaa Nasib, Shabkah, Alaa, Nixon Fulli, Alafi Francis, Nguyen, Alain, Mustafa, Alamin, Joseph, Alan, Huws, Alaw, Aregawi, Alazar Berhe, Sanchez Gallego, Alba, Torroella, Alba, Vazquez Melero, Alba, Dauksa, Albertas, Abreu Da Silva, Alberto, Brun-Peressut, Alberto, Barranquero, Alberto G, Gegúndez Simón, Alberto, Gerundo, Alberto, Navarrete-Peón, Alberto, Viacava, Alberto, Vilar, Alberto, Adam, Albushra Altayeb, Jarimba, Aldo, Johnson, Aleena, Nuñez Venzor, Alejandra, Gonzalez Ojeda, Alejandro, Romero De Diego, Alejandro, Karamarkovic, Aleksandar, Butyrskii, Aleksandr, Edmundson, Aleksandra, Sidorova, Aleksandra, Thomas, Alen, Tomazic, Ales, Giuliani, Alessandra, Iodice, Alessandra, Marano, Alessandra, Marello, Alessandra, Ongaro, Alessandra, Saba, Alessandra, Anastasi, Alessandro, Borello, Alessandro, Broglia, Alessandro, Carta, Alessandro, Finocchio, Alessandro, Francia, Alessandro, Iacomino, Alessandro, Izzo, Alessandro, Ottaiano, Alessandro, Spaziani, Alessandro, Strumia, Alessandro, Biancafarina, Alessia, D'Ignazio, Alessia, Davolio, Alessia, Morello, Alessia, Licciardello, Alessio, Mazzoni, Alessio, Wilkins, Alex, Arekhandia, Alexander, Barlas, Alexandros, Chamzin, Alexandros, Demetriou, Alexandros, Giakoustidis, Alexandros, Kozadinos, Alexandros, Kyriakidis, Alexandros, Sarakatsanos, Alexandros, Rojas, Alexei, Saridaki, Alexia, Litchinko, Alexis, Arnaud, Alexis P, Binder, Alf-Dorian, Yakubu, Alfa, Kavalakat, Alfie, Shamsutdinova, Alfiya, Alberico, Alfonso, Amendola, Alfonso, Sánchez-Terán, Alfonso Iván, Lapergola, Alfonso, Baiden Amissah, Alfred, Königsrainer, Alfred, Twumasi, Alfred, Alhebshi, Alhasan, Abbas, Ali, Abdul Rahman, Ali, Abidali, Ali, Abu Tair, Ali, Ahmad, Ali, Al Mukhtar, Ali, Sharq, Ali Al, Alloush, Ali, Amaigl, Ali, Kheirkhah Vakilabad, Ali Asghar, Bassma, Ali, Hacioglu, Ali Doruk, Elzanaty, Ali, Fani, Ali, Farsi, Ali, Ghummied, Ali, Hajali, Ali, Al Sharqi, Ali Hamed, Hammed, Ali, Hewari, Ali, Isler, Ali, Marouf, Ali, Uysal, Ali Mert, Murtada, Ali, Syed, Ali Naqi, Ozkomec, Ali, Sapmaz, Ali, Wassouf, Ali, Aldurssi, Alia, Polatbekov, Alibek, Caltagirone, Alice, Gori, Alice, Lim, Alicia, Bhatt, Alisha, Mohammed, Aljarrah, Maxwell, Allison, Kiyabayev, Almaz, Eltayeb, Almoutaz, Khamees, Almu'atasim, Abdalla, Alnazir, Pikarsky, Alon, Trigos Díaz, Alonso, A Elhars, Alshymaa, Alhaj Zain, Altayeb, Eltahir, Altayeb, Robin Valle De Lersundi, Alvaro, Sanad, Aly, Abdalhadi, Alya, Sparke, Alyssa, Maqsood-Shah, Amaal, Ali, Amal, Ouachhou, Amal, Ahmad, Aman, Kezze, Amana, Dawson, Amanda Caroline, Ali, Amani, Mohsen, Amani, Brar, Amanpreet, Dembele, Amara, Tansawet, Amarit, Obbeng, Ambe, Chiappini, Ambra, Davis, Amelia, Awidan, Amera, Tibude, Ameya, Shah, Ami, Hilder, Amie, Huremovic, Amila, Alamin, Amin, Egdeer, Amin, Gharib, Amin, Choudhary, Amin Mazhar, Amin, Amina, Ibrahim Hassan, Amina, Rashid, Amina, Patel, Aminah, Sebai, Amine, Asla, Amir, Ghanbari, Amir, Shweiki, Amir, Tursunovic, Amir, Aboshosha, Amira Abdelbadea Abdelhamed, Elbalal, Amira, Abdelhalim, Amira Ramadan, Gupta, Amit, Sinha, Amit, Al-Fandi, Amjad, Awwad, Amjad, Belaid, Amjad, Khatib, Amjad, Al-Zubeidy, Ammar, Niazi, Ammar, Zamareh, Ammar, Salam, Ammara, Ayodele, Amoda, Al Hammoud, Amr, Khouli, Amro, Crowe, Amy, Surkitt, Amy Louise, Alshiteewi, Amyirah, Alvarez Cuiñas, Ana, Cabral, Ana, Dupont, Ana, Faustino, Ana, Carreira-Marques, Ana Lúcia, Preto Barreira, Ana Lúcia, Minaya Bravo, Ana Maria, Pinheiro Pereira, Ana Marta, Minaya-Bravo, Ana, Lourenço, Ana Rita, Mateus Loureiro, Ana Rita, Sánchez Gollarte, Ana, Tvaladze, Ana, Veira, Ana, Perja, Ana-Maria, Dusabimana, Anaclet, Herewini, Anahera, Fatima, Anam, Zafar, Anam, Bangar, Anant, Kutma, Ananta, Mehta, Ananya, Alqerem, Anas, Jaber, Anas, Mourtzouni, Anastasia, Theochari, Anastasia, Zarafidou, Anastasia, Smyrnis, Anastasios, Tsechpenakis, Anastasios, Zakaria, Andee Dzulkarnaen, Cardoso Almeida, Andre, Pita, André, Torbey, André, Abreu, Andrea, Barberis, Andrea, Bartalini Cinughi De Pazzi, Andrea, Belli, Andrea, Sironi, Andrea Carlo, Damigella, Andrea, Manetti, Andrea, Mingoli, Andrea, Natili, Andrea, Police, Andrea, Razzore, Andrea, Scacchi, Andrea, Vazquez Fernandez, Andrea, Luzzi, Andrea-Pierre, Brosin, Andreas, Efstathiou, Andreas, Kirschniak, Andreas, Panagakis, Andreas, Pilavas, Andreas, Scheiwiller, Andreas, Skarpas, Andreas, Chitul, Andrei, Trif, Andrei, Ferreira, Andreia, Silva, Andreia, Subocius, Andrejus, Cembellin, Andres, García Marín, Andrés, Ang, Andrew, Gray, Andrew, Li, Andrew, Skreka, Androniki-Maria, Abdul Rahim, Andy Adib, Bhangu, Aneel, Moncy, Aneena, Mwanjoka, Anganile, Fernández Camuñas, Ángel, De Jesús Gil, Ángela, Molero, Ángela, Sultana, Angela, Suárez Álvarez, Angeles Anabel, Nava Franco, Angelica Magaly, Autiak Ayii Chol, Angelo, Serao, Angelo, Nikolaou, Angelos I., Hassanin, Angham, Evans, Angharad, Vu, Anh, Lala, Anil Kumar, Luther, Anil, Sundaram, Anil, Cerovac, Anis, Abgeko, Anita Eseenam, Agbeko, Anita Eseenam, Sharma, Anju, Gupta, Ankit, Jain, Ankit, Attili, Ann, Alecci, Anna, D'Amore, Anna, Domenech Plana, Anna, Gut, Anna Eleonora, John, Anna, Lareida, Anna, Pesce, Anna Lisa, Paspala, Anna, Sharp, Anna, Victor, Anna, Comandatore, Annalisa, Olsen, Annelisse, Yiallourou, Anneza, Loizou, Annita, Sharma, Anshuman, Asare Twumasi, Anthony, Davor, Anthony, Tabiim, Anthony Jagri, Lin, Anthony, Szpytko, Anthony, Walfor, Anthony, Oosterkamp, Antje, Kachi, Antoine, Khoneisser, Antoine, Bediako Bowan, Antoinette, Sumbaev, Anton, Deserra, Antonello, Punzengruber, Antonia, Thanasa, Antonia, Azzinnaro, Antonio, Castaldi, Antonio, Curado Soriano, Antonio, García Domínguez, Antonio, Lai, Antonio, Martinez German, Antonio, Masciandaro, Antonio, Miele, Antonio, Pesce, Antonio, Ramírez Beas, Antonio, Ramos Bonilla, Antonio, Ramos-De la Medina, Antonio, Zerbinati, Antonio, Athanasiou, Antonios, Panagidis, Antonios, Vezakis, Antonios, Pilavas, Antonis, Boynes, Antony, Mishra, Anurag, Singh, Anurag, Appukuttan, Anuraj, Alhamadi, Anwaar, Gusibat, Anwar, Seidu, Anwar Sadat, Fuertes Muñoz, Anyely Nataly, Abbas, Aoss, Shanker, Aparajeya, Balta, Apostolia, Panagopoulos, Apostolis, Roslani, April, Tahir, Aqsa, Hernández, Araceli, Roumieh, Aram, Pinto, Arbey, Khanduri, Archana, Isik, Arda, Dhinakar, Arelly Samuel Paul, Ioannidis, Argyrios, Tsiaka, Ariadni, Balconi, Arianna, Petrungaro, Arianna, Narin, Arif Emir, Plastiras, Aris, Papadopoulos, Aristeidis, Kontokostopoulos, Aristeidis-Panagiotis, Bang, Aristide, Nikitaras, Aristotelis, Akiba, Arit, Jindal, Arjun, Bedzhanyan, Arkady, Fajardo, Arlene, Antinori, Armando, Galvan, Armando, Belarmino, Armin, Mustafa, Arooba, Mathew, Arpit, Pillai, Arpit, Alrababah, Arqam, Shoker, Arran, Hai, Arrham, Anand, Arun, Bhatti, Arun, Nair, Arun, Prasath S V, Arun, Krishna, Arunachalam, Sinha, Arvind, Abdulnabi, Arwa, Aboumedian, Arwa, Faisal, Arwa, Haidar, Arwa, J, Arya, Ahmed, Asaad, Choudhry, Asad, Albager, Asawer, Jha, Ashesh Kumar, Chhabra, Ashish, Choudhrie, Ashish, Gupta, Ashish, Kumar, Ashish, Tirkey, Ashish, Oommen, Ashok Ninan, Al-Bahla, Ashraf, Bakri, Ashraf, Maghrabi, Ashraf, Mahendran, Ashuvini, Kumar, Ashwani, Das, Asish, Eisa, Assem, Comella, Assia, Shanmugalingam, Aswin, Boztaş Demir, Asya Eylem, Zubillaga-Mares, Asya, Altawaiha, Ata'O Allah, Mitsala, Athanasia, Katsiou, Athanasia-Faidra, Bakalis, Athanasios, Marinis, Athanasios, Migdanis, Athanasios, Soumpasis, Athanasios, Syllaios, Athanasios, Tampakis, Athanasios, Çakmak, Atil, Rahman, Atiqur, Suroy, Atul, L'Hostis, Audrey, Parseliunas, Audrius, Ali, Aun, Rakotondrainibe, Aurelia, Goliath, Austin, Arustamyan, Avetik, Sukhdev Jadhav, Avinash, Chaudhary, Awais, Kumar, Awanish, Denz, Axel, Al Kaddah, Aya, Alaqtash, Aya, Ehab, Aya, Essamei, Aya, Kelzia, Aya, Farrag, Ayatallah, Myintmo, Aye Myat, Bibi, Ayesha, Iqbal, Ayesha, Irshad, Ayeza, Sinjab, Ayham, Izgiş, Aylin, Almugaddami, Ayman Adel Yousuf, Albatanony, Ayman, Ayeni, Ayodeji, Williams, Ayooluwa, AbuNemer, Ayoub, Benmansour, Ayoub, Nidali, Ayoub, Vig, Ayushi, Emran, Ayyah, Abbas, Azadar, Ekpeti, Azuka, Janjua, Azwa, Fathi, Azza, Alzahrani, Azzah, Rehmani, Babar, Ayoade, Babatunde A, Mustapha, Babatunde, L, Badareesh, Alsharari, Bader, Balaravi Pillai, Balakavitha, Balagobi, Balasingam, Mohamad, Balqees, Ibrahim, Bana, Ali, Bandar, Alqahtani, Bandar, Paul, Banderembako, Yigit, Banu, Révérien, Banziriyubusa, Dweik, Bara', Yacoub, Bara', Alzoubi, Baraa, Chkir, Baraa, M.J. Alhaj, Baraa, Binda, Barbara, Carvalho, Bárbara, Demurtas, Barbara, Dieck, Bárbara, Freire, Bárbara, Gama, Bárbara, Habrat, Barbara, Tinoco, Bárbara, Hernandez Cervantes, Barbara Yordanis, East, Barbora, Maguire, Barry, Mckay, Bartholomew, Żaczek, Bartłomiej, Dawud, Bashar, Allbakosh, Bashir, Yunusa, Bashir, Aminu, Bashiru, Ibi, Bashkim, D'Souza, Basil, Alazabi, Basma, Algettawi, Basma, Sharaf Eldin, Basma, Hameed, Basmah Hilal, Abboud, Bassam, Al Soudi, Bassam, Fahmy, Bassam, Ranjous, Batoul, Bereket Araya, Batseba, Eyduran, Batuhan, Alsaid, Bayan, Guerra, Bayron, Markowska, Beata, De Zolt Ponte, Beatrice, Robertson-Jones, Beatrice, Sperotto, Beatrice, Cordeiro, Beatriz, Cuneo, Beatriz, De Andrés-Asenjo, Beatriz, Louro, Beatriz, Estraviz, Begoña, Khan, Belawl, Abdennour, Belkadi, Calcaño, Bellanirys, Kigwe, Ben, Boakye, Benedict, Ağca, Bengi, Togay, Bengü, Esposito, Beniamino, Chiman, Benjamin Guarken, Lulham-Robinson, Benjamin, Martin, Benjamin, Peter, Bennett, Özcan, Berkay, Seshie, Bernard Kofi, Maanikuu, Bernard, Lopes Patrício, Bernardo, Khattab, Besher, Johnson, Bethan, Mcdermott, Bethany, Neall, Bethany, Wang, Betty, Roopavathana. S, Beulah, Fosh, Beverley, Sarang, Bhakti, Sv, Bharath, R Budihal, Bhargavi, Devkaran, Bhavesh, Van Zyl, Bianca, Kharga, Bikram, Al-Sarireh, Bilal, Ali, Bilal, Duman, Bilgesu, Baca, Bilgi, Down, Billy, Mengesha, Birhanu, Owusu Ansah, Bismark, Radja, Bitour, Sime, Bizuneh, Capdevila Vilaró, Blanca, Izedomi, Blessing Ohikhuare, Hao, Bo Zhen, Nimako, Boateng, Phakathi, Boitumelo, Sehgal, Boney, Cakpo, Boniface, Alrayes, Bourhan, Mao, Boyuan, Bogdan-Gabriel, Bratu, Bengaly, Bréhima, Williams, Brielle, Cismasiu, Brigitta, Helou, Brigitte, Davies, Brooke, Arya, Brundha, Cirillo, Bruno, Nardo, Bruno, Pinto, Bruno, Scotto, Bruno, Vieira, Bruno, Kadir, Bryar, Albaihani, Bshaer, Calik, Bulent, Citgez, Bulent, Celik, Burak, Azhar, Burhansyah, Alshaikh, Bushra, Kum, Büşra, Killoran, Callie, Nwachukwu, Callistus, Hidalgo Salinas, Camila, Brasset, Camille, Bertoglio, Camillo Leonardo, Vasquez Maya, Camilo, Zapata Syro, Camilo, Akgün, Can, Yurttas, Can, Semeraro, Candy, Lategan, Carina, Boven, Carine, Uwakunda, Carine, Leal Ferrandis, Carla, Margiani, Carla, Piras, Carla, Samojeden, Carla, Vitiello, Carla, Feo, Carlo V., Bôto, Carlos, Roman Ortega, Carlos Fernando, Ferreras García, Carlos, Figueiredo, Carlos, García-Salas, Carlos, González, Carlos, González Baez, Carlos, Gracia-Roche, Carlos, Guijarro Moreno, Carlos, Hernandez Diaz, Carlos, Ferrero, Carlos Ignacio, Perez Rivera, Carlos J, Jezieniecki, Carlos, Pérez - Padrón, Carlos Josué, León-Espinoza, Carlos, Nuño-Guzmán, Carlos M., Macedo Cardoso De Oliveira, Carlos, Shiraishi Zapata, Carlos, Yanowsky-Gonzalez, Carlos, Sorrentino, Carmen, Tung, Carmen, Cardoso, Carolina, Chavarría Noya, Carolina, Coutinho, Carolina, Korzin, Carolina, Maya, Carolina, Moreno-Licea, Carolina, Panis, Carolina, Righetti, Carolina, Silva, Carolina, Soares-Aquino, Carolina, Golliez, Caroline, Chiam, Carolyn, Kamphues, Carsten, Rahantasoa Finaritra, Casimir Fp, Assis, Catarina, Henriques, Catarina, Quintela, Catarina, Rio Ferreira, Catarina, Rolo Santos, Catarina, Rodrigues, Catarina S., Allmer, Caterina, Bradshaw, Catherine Jane, Rukundo, Cédric, Seneza, Celestin, Raphael, Celine, Guldogan, Cem Emir, Bilir, Cemal, Hacıalioğlu, Cemal, Ersavas, Cenk, Özkan, Cenk, Huaroto Landeo, Cesar Fernando, Ginesta, Cesar, Infante, César, Pastás, César, Ciubotaru, Cezar, Narayan, Chanchal, Mahakalkar, Chandrashekhar, Floros, Charalampos, Demiri, Charikleia, Chatzinikolaou, Charito, Dempers, Charl, Ansah Larbi, Charles, Banka, Charles, Cini, Charles, Dally, Charles, Doku, Charles, Ntow-Boahen, Charles Kwaku, Nicholson Jr., Charles, Cornwell, Charlotte, Stennard, Charlotte, Lionel, Charre, Azmat, Chaudhary Ehtsham, Nyampinga, Chelsea, Tandup, Cherring, Agarwal, Chetan, Parmar, Chetan, Pun, Chetna, Un, Chi Wen, Baars, Chiara Anne, Celano, Chiara, Fumagalli, Chiara, Marafante, Chiara, Zandonella, Chiara, Nwanmah, Chibueze, Osuigwe, Chidimma, Nwokoro, Chigbundu, Nwosu, Chikaodili, Nwosu, Chimdiebele Daisy, Lim, Chin Kent, Ónyeka, Chinonso, Uche, Chisom, Jamieson-Grigg, Chloe, Ong, Chon Sum, Alphonse, Chris, Bode, Chris, Varghese, Chris, Carrillo Sarango, Christian, Esteo Verdu, Christian, Krautz, Christian, Mosca, Christian, Nimbona, Christian, Nikolaou, Christina, Wiesner, Christina, Kloppers, Christo, Kourouniotis, Christoforos, Seiler, Christoph, Knee, Christopha, Mpirimbanyi, Christophe, Aboah, Christopher, Amah, Christopher, Cheong, Christopher, Harmston, Christopher, Leung, Christopher, Seet, Christopher, Smart, Christopher, Chouliaras, Christos, Damaskos, Christos, Doudakmanis, Christos, Kaselas, Christos, Limas, Christos, Ntagkas, Christos, Papazacharias, Christos, Stefanou, Christos, Thrasyvoulou, Christos, Tsalikidis, Christos, Karagianni, Chrysanthi, Kolla, Chrysoula-Christina, Ugwunne, Chuka, Ilo, Chukwudi, Nwegbu, Chukwuemeka, Onwuzu, Chukwuka, Weadick, Ciara, De Martino, Ciro, Donohoe, Claire, Gutierrez De La Rosa, Clara Elena, Florián Villa, Clara Marcela, Petcu, Clara Teodora, Cecconi, Claudia, Banal, Claudine, Brandi, Claudio, Hossu, Claudiu, Onuoha, Clement, Osime, Clement, Shelton, Clifford, Fuentes Orozco, Clotilde, Adumah, Collins, Dina, Constantin, Nastos, Constantinos, Aguero, Coral, Markin, Coretta, Hoogerboord, Cornelis, Da Lio, Corrado, Saviello, Cosimo, Bezede, Cosmin, Distefano, Costanza, Elliot-Wilson, Courtney, Bokossa, Covalic, Lupercio Figueroa, Cristian Israel, Riboni, Cristiana, Meola, Cristiano, Costa, Cristina, Gas, Cristina, Larotonda, Cristina, Soddu, Cristina, Vacca, Cristina, Vera Mansilla, Cristina, Li, Crystal, Agbonrofo, Cynthia, Akli-Nartey, Cynthia, Molewa, Cynthia, Nelly Rosine, Cyuzuzo Ngwije, Rega, D., Koike, Daisuke, Wickramasinghe, Dakshitha, Clarke, Damian, Fry, Damian, Hannedige, Damsadie, Powell, Dan-Beck, Kasasbeh, Dana, Samardali, Dana, Sharl Ajami, Dani, Badran, Dania, Adjei, Daniel, Muhie, Daniel Ahmed, Pérez Muñoz, Daniel Alejandro, Alifoe, Daniel, Aparicio-López, Daniel, Baños Méndez, Daniel, Cristian, Daniel, Eaton, Daniel, Gero, Daniel, Makary, Daniel, Montwedi, Daniel, Muñoz, Daniel, Patterson, Daniel, Reim, Daniel, Agbley, Daniel Yao Dodzie, Patiño García, Daniela Cristina, Di Pietrantonio, Daniela, Pais, Daniela, Rosado, Daniela, Tavares, Daniela, Alberti, Daniele, Fusario, Daniele, Massaro, Daniele, Paglione, Daniele, Pironi, Daniele, Kurochka, Daniil, Centonze, Danilo Corrado, Hackner, Danilo, Herrera, Danilo, Amangaliyev, Daniyar, Silva-Cano, Danny Wladimir, Chaudhry, Daoud, Palmisano, Dario, Ribero, Dario, Vukosav, Dario, Misca, Darius, Lowen, Darren, Rattray, Darren, Walia, Darshanjit Singh, Maan, Darvesh, Muyenzi, Daryle, Verdi, Daunia, Bardsley, David, Reyes Rodríguez, David Estuardo, Fra Corral, David, Garcia López De Goicoechea, David, Gavit, David, Gómez, David, Idowu, David, Konkin, David, Labadah, David Kplorla Kekeli, Liu, David, Merlini, David, Mitchell, David, Moro-Valdezate, David, Osifo, David, Proud, David, Ridder, David, Gobatti, Davide, Muschitiello, Davide, Pertile, Davide, Zulian, Davide, Mengiste, Dawit, Mikami, Dean, Mohanty, Debajyoti, Chatterjee, Debarghya, Komolafe, Deborah Olaitan, Scotto Di Carlo, Deborah, Wright, Deborah, Rahme, Deema, Talreja, Deep Parkash, Jain, Deepak, Rajput, Deepak, Singh, Deepak, Anbu, Deepika, Ibrahim, Dena, Phom, Denchu, Hili, Denise, Osei, Dennis Broni, Daary, Dennis, Kyeremeh, Dennis, Shen, Dennis, Uymaz, Derya Salim, Cianflocca, Desiree, Ashitey, Desmond, Evripidou, Despo, Papageorgouli, Despoina, Kaushal, Devesh, Abeysirigunawardana, Dewmi, Dugar, Dharmendra, Mallik, Dhiraj, Ghosh, Dhruva, Houmran, Diaa, Abdulrahman, Diala, Pantoja Pachajoa, Diana Alejandra, Cardona Gomez, Diana Catalina, Fenner, Diana, Gonzalez, Diana Samantha, Siriwardena, Diana, Garcés Palacios, Diana Sofía, Stoian, Diana, Zuikyte, Diana, Sosa Méndez, Dianne Alitzá, Wickramarathna, Dickson, Mutter, Didier, Palma Portillo, Diego Andrés, Chavez Fernandez, Diego, Córdova García, Diego, Enjuto, Diego, Giulitti, Diego, Sasia, Diego, Visconti, Diego, Yiğit, Dilara, George, Dilip, Rabaia, Dima, Georgiev, Dimitar, Hadzhiev, Dimitar, Alexandrou, Dimitrios, Balalis, Dimitrios, Giakoustidis, Dimitrios, Manatakis, Dimitrios K., Korkolis, Dimitrios, Lytras, Dimitrios, Massaras, Dimitrios, Moris, Dimitrios, Politis, Dimitrios, Sampanis, Dimitrios, Schizas, Dimitrios, Tsiardas, Dimitrios, Vardakostas, Dimitrios, Kotsaris, Dimitris, Khattab, Dina Hesham, M. Awad, Dina, Alrokh, Dina Sami, Schippers, Dina, Waleed, Dina, Salinovic, Dinko, Gonçalves Múrias Gomes, Diogo Miguel, Silva, Diogo, Vaz Acosta, Diogo, Morton, Dion, Panagopoulos, Dionisios, Kelgiorgi, Dionysia, Dellaportas, Dionysios, Prevezanos, Dionysios, Joshi, Dipti, Ozal, Direm, Yigit, Direnc, Chimkaomasiri, Divine, Jabbar, Diya, Nepogodiev, Dmitri, Belekar, Dnyanesh, Abdalaziz, Doaa, Abunemer, Doaa, Attia, Doaa, Elkafrawy, Doaa, Dimitrov, Dobromir, Pignatelli, Domenica, Merlicco, Domenico, Soriero, Domenico, Zerbo, Domenico, Atouguia, Domingas, Fairbrass, Dominic, T. Enti, Donald, Venskutonis, Donatas, Rukavina, Dora, Caruso, Dorena, Herappe, Dorihela, Lee, Dorinda Norbetha, Ofosuhene, Doris, Hajela, Apoorva, Badwan, Basem, Kulkarni, Datta, Dhawan, Deep, Dhillon, Jeevanjit, Mehmood, Manzer, Mahmood, Namrah, Nikam, Narendra, Ramchandani, Radhakrishna, Thind, Ravinder Singh, Riazhussain, D Hafiz, Maqsood, Saliha, Alalawi, Yousef, Tyagi, Harshdeep, Kshirsagar, Shivani, Ahmed, Hisham, Juan Carlos, Luna Cydejko, Kone, Dramane, Omar, Duaa, Alves, Duarte Gil, Subasinghe, Duminda, Ommi, Durgesh, Joshiba, Durshney, Chakarov, Dzhevdet, Arkoh, Ebenezer Ameyaw, Frimpong-Manso, Ebenezer, Ada, Ece, Lincango, Eddy P., Lozada Hernandez, Edgard Efren, Hodžić, Edin, Di Marco, Edith, Baccalini, Edoardo Andrea, Baldini, Edoardo, González Marín, Eduardo, Gutierrez, Eduardo, Sepúlveda, Eduardo, Dainius, Edvinas, Zhang, Edward, Yenli, Edwin Mwintiereh Ta-Ang, Antoniou, Efstathios, Kapasakis, Efstathios, Baili, Efstratia, Poulios, Efthymios, Kubiliute, Egle, Osaze, Ehioghae, Afeikhena, Ehis, Elshennawy, Eiad, Athanasopoulou, Eirini, Synekidou, Eirini, Ekaladze, Eka, Tampaki, Ekaterini Christina, Adam, Elaf, Adel Hamdoun Aziz, Elaf, Yousuf, Elamin, Gialamas, Eleftherios, Spartalis, Eleftherios, Bedzhanyan, Elen, Toma, Elena Adelina, Daukšaitė, Elena, Desiato, Elena, Dvivedi, Elena, Hadzhieva, Elena, Martí Cuñat, Elena, Montalbán Martínez, Elena, Montanari, Elena, Signaroli, Elenasofia, Efremidou, Eleni, Gavriil, Eleni, Karakeke, Eleni, Mavrodimitraki, Eleni, Papamattheou, Eleni, Jose, Elenza, Cianci, Eleonora, Ciccioli, Eleonora, Daleva, Eleonora, Locci, Eleonora, Lori, Eleonora, Silanos, Eleonora, Ayala, Elí, Bankart, Eliana, Brolese, Eliane, Efstathiou, Elias, Salloum, Elias, Colak, Elif, Terzi, Elif Didem, Ametefe, Elikem, Cagigal Ortega, Elima Pilar, Donnarumma, Elio, Mina, Elisa, Reitano, Elisa, Wallner, Elisabeth, Moggia, Elisabetta, Betz, Elise, Kontis, Elissaios, Anestiadou, Elissavet, Gimson, Eliza, Lun, Elizabeth, Fraser, Elizabeth, Li, Elizabeth, Torres De Anda, Elizabeth Magaly, Murphy, Elizabeth Mary Ann, O'Connell, Elizabeth, Redondo, Elizabeth, Lun, Elizabeth Weng Yan, Francis, Ella, Haiden, Elmar, Hamed, Elmonzir, Alkhalifa, Elmustafa, Dexter, Eloise, Daketsey, Elorm, Setsoafia, Elorm, Mohamed, Elsagad, Mohammed, Elsamoual, Hegab, Elsayed, Ay, Elvin, Adinolfi, Elvira, Mbanzabugabo, Elvis, Chin, Elynn, Ahmed, Emad Ali, Younes, Eman, Basile, Emanuela, Gessa, Emanuela, Pontecorvi, Emanuele, Romairone, Emanuele, Hatangimana, Eméry, Ndizeye, Emile, Ciofic, Emilia, Dijan, Emilio, López-Negrete Cueto, Emilio, Baker, Emily, Reid, Emily, Schmidt, Emily, Alić, Emir, Bičakčić, Emir, Agbowada, Emma, Colton, Emma, Downing, Emma, Haege, Emma, O'Neill, Emma, Roussos, Emmanouel, Nachelleh, Emmanuel Aadereyir, Adebunmi, Emmanuel, Obiesie, Emmanuel Ahuizechukwu, Akakpo, Emmanuel Bismark, Konlan, Emmanuel Dammigu Francis, Nwangwu, Emmanuel Ifeanyi, Kafui Ayodeji, Emmanuel, Ofori, Emmanuel Owusu, Spanoudakis, Emmanuel, Abate, Emmanuele, Balik, Emre, Bozdağ, Emre, Bozkurt, Emre, Karabulut, Emre Cagri, Ozoran, Emre, Tunçcan, Emre, Tuzuner, Emre, Halilović, Emsad, Alabed, Enaam, Zidan, Enas, Hodžić, Enes, Aybar, Engin, Yildirim, Engin Okan, Wong, Enoch, Yhoshu, Enono, Bisogno, Enrica, Andolfi, Enrico, Ferri, Enrico, Potenza, Enrico, Spalice, Enrico, Volpin, Enrico, González, Enrique, Downes, Eoin, Gallo, Erdachew, Kamer, Erdinc, Naidoo, Eressa, Erginöz, Ergin, Bara, Eric, Irungu, Eric, García-Villegas, Eric Yusif, Mazzotta, Erica, Monati, Erica, Chan, Erick, Gómez Mejía, Erika, Dylja, Eris, Somuncu, Erkan, Yavuz, Erkan, Begunić, Ernes, Margelis, Ernest, Osei, Ernest Owusu, Saitoglou, Ertzan, Agastra, Ervis, Mazumdar, Eshan, Soyer Güldoğan, Esra, Abu Siam, Esra'A, Abdelbaset, Esraa, Abdu, Esraa, Adel Mahmod Sultan, Esraa, Nubi Mohamed, Esraa Gamal, Abuobaida Banaga Hag El Tayeb, Essam Eldien, Ali, Essraa, Page-Taylor, Estelle, Marra, Ester, Garcia Santos, Esther Pilar, Elsheikh, Ethar, Unal, Ethem, Tan, Eugene, De Leo, Eugenio, Borges, Eva, Gáspár, Éva, Ruiz-Daum, Eva, Apostolopoulos, Evaggelos, Samara, Evangelia, Barkolias, Evangelos, Fradelos, Evangelos, Hopping, Eve, Romo Ascencio, Evelia Veronica, Sosa Ferreira, Ever David, Shestakov, Evgenii, Tyurina, Evgenya, Hristova, Evguenia, Efthymiou, Evripidis, Tokidis, Evripidis, Harrison, Ewen, Dontoh, Ewurama Akroma, Mansour, Eyad, Yeshialem, Eyosiyas, Dabbagh, Ezeddin, Amer, Ezzeldin, Manasci, Fabiana, Gomes, Fabio, Medas, Fabio, d'Acapito, Fabrizio, Vassallo, Fabrizio, Haddad, Fadi, Elhabishi, Fadwa, Akhtar, Fahad, Tauheed, Fahad, Al Abbood, Fahd, Gareb, Fahed, Ghazali, Fairuz, Alnazawi, Faisal, Ondago, Faith, Rasoaherinomenjanahary, Fanjandrainy, Wiese, Fanny, González Ponce, Fanny Yesenia, Georgiades, Fanourios, Ali, Farah, Galley, Fareeda, Huda, Farhanul, Amir, Farhat Naaz, Ashraf, Fariha, Alfarsi, Faris, Ayasra, Faris, Ali, Farman, Mahmoud, Faten, Aliskander, Fater, Tahir Lwdie, Fathea, Buyuker, Fatih, Aguilar Del Castillo, Fátima, Mohammed Daoud, Fatima Ahmed, Alowjaly, Fatima, Oni, Fatima, Rauf, Fatima, Elkhafeefi, Fatimah, Hourri, Fatine, Monib, Fatma A., Alshreef, Fatma, Benghalbon, Fatma, Ntirenganya, Faustin, Ashraf, Fauziyah, Chahrour, Fayez, Ahmad, Fazal, Parray, Fazlul Qadir, Philips, Febi, Campus, Federica, Di Marco, Federica, Ferraina, Federica, Frongia, Federica, Maffeis, Federica, Natali, Federica, Pederiva, Federica, Scolari, Federica, Tofani, Federica, Marin, Federico Alberto Niccolò, Biolchini, Federico, Cappellacci, Federico, Corronca, Federico, Mazzola, Federico, Suldrup, Federico, Nyarko, Felicia, Casas J, Felipe, Zapata, Felipe, Aigner, Felix, Alakaloko, Felix, Amoako, Felix, Camacho, Felix, Hammett, Felix, Kuubetersob B. N, Felix, Alahmad, Feras, Alnimri, Feras, Haddad, Feras, Gool, Ferhana, Castro, Fernanda, Diaz, Fernanda, Lucero, Fernanda, Vovola, Fernanda, Mahnic, Fernando, Mercado Sanchez, Fernando, Prieto La Noire, Fernando, Soggiu, Fiammetta, Tsige, Fikreab, Brzeszczyński, Filip, Rudisch, Filip, Valente Costa Pinto, Filipa, Ramalho De Almeida, Filipe, Banchini, Filippo, Palomino Escalante, Fiorella, Fadzlullah, Fitri, Terefe, Fitsum, Sulo, Fjorenta, Ciccarone, Flavia, Tirelli, Flavio, Krämer, Florian, Grama, Florin, Spanos, Foivos, Solimene, Folco, Akinwande, Foluso, Osman, Forzia, Stefou, Foteini, Kyramargios, Fotios, Stavratis, Fotios, Alassani, Fousseni, Ascari, Francesca, Cammelli, Francesca, D'Agostino, Francesca, Tropeano, Francesca Paola, Peters, Francesca, Ré, Francesca, Brucchi, Francesco, Casti, Francesco, Coratti, Francesco, Ferrara, Francesco, Floris, Francesco, Izzo, Francesco, Maffei, Francesco, Palmieri, Francesco, Pata, Francesco, Porcelli, Francesco, Selvaggi, Francesco, Velluti, Francesco, Mulita, Francesk, Bello, Francis, Caiquo, Francis, Dossou, Francis, Eshun, Francis Junior, Opoku Twene, Francis, Tierenye, Francis, Quayson, Francis William, Romo Rosales, Francisco David, Ibañez Ortiz, Francisco, León Frutos, Francisco Javier, Redondo Calvo, Francisco Javier, Silva Rivera, Francisco Javier, Barbosa Camacho, Francisco José, Bujalance Cabrera, Francisco Manuel, Ruescas, Francisco, Irakiza, Franck Fanon, Corvatta, Franco, Pascual, Franco Raúl, Roviello, Franco, Roodt, Francois, Gyamfi, Frank Enoch, Olaniru, Frank, Owusu, Frank, Bader, Franz G., Anzinger, Franz-Xaver, Agbodo, Fred David Anku, Ris, Frederic, Agbemafoh, Frederick Mawuli, Afonso, Frederico, Nazareth, Frederico, Berrevoet, Frederik, Hounde, Fréjus, Demiral, Furkan, Hassooni, Furqan Ridha Hassooni, Kafa, Gabi, Cárdenas Rivera, Gabriel, Ntwari, Gabriel, Szydlo Shein, Gabriel, Ambriz González, Gabriela, Nita, Gabriela Elisa, Bellio, Gabriele, Moitzi, Gabriele, Urdang, Gabriella, Marom, Gad, Gallo, Gaetano, Luglio, Gaetano, Poillucci, Gaetano, Singh, Gagandeep, Saletta, Gaia, Abouelnagah, Galal, Yarovenko, Galina, Kazobinka, Gallina, Ahmed, Gamal Mutwakil Gamal, Rahman, Ganiyu Adebisi, Smith, Garett, Pillai, Gargi, Saxena, Garima, Gbessi, Gaspard, Nkunguzi, Gaston, Jalal, Gaurav, Chillarge, Gauri, Singh, Gautam, Mevognon, Gedeon, Getachew, Gedion, George, Gejoe, De La Peña González, Gema, Martínez Izquierdo, Gema, Grande, Gennaro, Birikorang, Geoffrey, Weber, Georg F., Singer, Georg, Ansong, George, Bashour, George, Brown, George Darko, Hneino, George, Kavalieratos, George, Kenchadze, George, Nagy, George, Pappas Gogos, George, Skroubis, George, Waiyaki, George, Cox, Georgia, Zeringa, Georgia, De Wee, Georgin, Hart, Georgina, Bekakos, Georgios, Fragulidis, Georgios, Kapogiannatos, Georgios, Karakaidos, Georgios, Kokkinos, Georgios, Kostoulas, Georgios, Koukoulis, Georgios, Peros, Georgios, Rados, Georgios, Tsoulfas, Georgios, Verras, Georgios-Ioannis, Berger, Geraint, Adoro, Gerard Ayuka, Chamoso Mialdea, Gerardo, Palmieri, Gerardo, Procaccini, Gerardo, Steenkamp, Gerhard, Viscido, Germán Rodrigo, Dajti, Gerti, Alemayehu, Getachew, Seyfu, Gezachew, Birqeeq, Ghada, Alsheikh, Ghadeer, Alrayyes, Ghaith, El Hunjul, Ghalib Nashaat, Zaza, Ghayath, Matroud, Ghazlah, Alhadwah, Ghena, Maltinti, Gherardo, Awais, Ghina, Shamsi, Ghina, Calini, Giacomo, Carganico, Giacomo, Zanus, Giacomo, Canu, Gian Luigi, Mendiola, Gian, Ibero Casadiego, Giana Pamela, Cocorullo, Gianfranco, Baronio, Gianluca, Pellino, Gianluca, Zanni, Gianluca, Poto, Gianmario Edoardo, Gravante, Gianpiero, Aduroja, Gideon, Almogy, Gidon, Bond-Smith, Giles, Natchagande, Gilles, Bechara, Gio, Brachini, Gioia, Riccioli, Giordana, Ercolani, Giorgio, Farris, Giorgio, Giraudo, Giorgio, Mammolo, Giovanna, Pavone, Giovanna, Sgarzini, Giovanna, Aprea, Giovanni, Fonsi, Giovanni Battista, Boroni, Giovanni, De Angeli, Giovanni, De Palma, Giovanni Domenico, Emiliani, Giovanni, Grava, Giovanni, Guercio, Giovanni, De Carlo, Giulia, Del Corpo, Giulia, Duranti, Giulia, Galatioto, Giulia, Grassi, Giulia, Graziano, Giulia, Marini, Giulia Maria Francesca, Munzi, Giulia, Tarantino, Giulia, Borda-Luque, Giuliano, Pellicano', Giuseppe Antonino, Canonico, Giuseppe, Carollo, Giuseppe, Ietto, Giuseppe, Palomba, Giuseppe, Pascarella, Giuseppe, Salamone, Giuseppe, Sica, Giuseppe, Sorrentino, Giuseppe, Orlando, Giuseppina, Pignata, Giusto, Pisarevi, Givi, Akcakoca, Gizem, Owusu, Godfred, Yohanna Abrak, Godwin, Kurtoglu, Gokalp Kagan, Kurtoglugk, Gokalp Kagan, Alıcı, Gökhan, Kurtoglu, Goktug Mert, Delgado Hernandez, Gonzalo, Augustin, Goran, Bhat, Gowhar Aziz, Sundaram Venkatesan, Gowtham, Chang, Grace, Eke, Grace, Lee, Grace, Massarra, Grace, Travaglini, Grazia, Scialandrone, Grazisa, Stavrou, Gregor A., Di Franco, Gregorio, Charalambous, Gregory, Christodoulidis, Gregory, Kouraklis, Gregory, Goodwin, Gregory Richard, Devidze, Grigol, Fialho, Guilherme, Santos, Guilherme, Cabezudo, Guillermo, García-Santos, Guillermo, Pou, Guillermo, Romero Reyna, Guillermo, Yanowsky-Reyes, Guillermo, Ozyuksel, Gul, Karadeniz Cakmak, Guldeniz, Kucuk, Gultekin Ozan, Bulbuloglu, Guney Cem, Sarp, Guray, Kaur, Gurleen, Nibogora, Guy Darcy, Hamdan, Gymar, Ogundipe, Habeeb, Yunes, Habib, Ayesh, Hadeel, Al Atassi, Hadi, Jalilehvand, Hadis, Masalma, Hafez, Jafarkhan, Hafis, Shahid, Hafiz Huzaifa, Younus, Hafsa, Al-Derume, Hail, Shames, Haitam, Mimouni, Haithem Ahmed, Aldare, Hajar, Odah Bashi, Hajar Omar, Abusnina, Hajer, Altounsi, Hajir, Qayum, Hajra, Baysal, Hakan, Bolukbasi, Hakan, Yigitbas, Hakan, Alkhatib, Hala, Afzal, Haleema, Mftah, Halima, Oyinlola, Halimah, Tümer, Haluk, Dolo, Hamadoun, Braham, Hamdi, Ozsahin, Hamdi, Abu-Arish, Hamdoon, Al-Aamri, Hamed, Fadlalmola, Hammad Ali, Abu Obead, Hamza, Al-Fahel, Hamza, Al-Zoubi, Hamza, Asaad, Hamza, Ejaz, Hamza, Jaber, Hamza, Bhatti, Hamza Waqar, Mohammadi Sardoo, Hamzeh, Farhat, Hana, Idheiraj, Hanadi, Zwaraa, Hanady, Al Sohabi, Hanan, Basharat, Hanan, Said, Hanan, Al-Abdallat, Haneen, Foad, Haneen, Daaboul, Hanen, Al Qadhi, Hani, Elhallaq, Hani, Alhusaini, Hanin, Lidbetter, Hannah, Reilly, Hannah, Moya- Ambriz, Hannia Betzabeth, Lederhuber, Hans, Fehrer, Hans-Jörg, Xiao, Haotian, Iswariah, Harish, Kaur, Harmeena, Cheema, Harnoor Kaur, Foda, Haroun, Chauhan, Harpreet, Kaur, Harpreet, Sagar, Harry, Unwin, Harry, Kaur, Harsharan, Panga, Harshavardhan, Gupta, Harshit, Prabhakar, Harshit Kumar, Anand, Harshitha, Pahwa, Harvinder Singh, Abbadi, Hasan, Amoudi, Hasan, Zaini, Hasan Hadi Zaini, Škiljo, Hasan, Miyasika, Hasangi, Altabbaa, Hashem, Haj Freej, Hasn, Abdelazim, Hassan, Habiba, Hassan, Kamal, Hassan, Sabir, Hassan, Zaigham, Hassan, Pehlivan, Hatice, Telci, Hatice, Abuobaida, Hayat, Tetley, Heather, Taher, Heba, Aguado López, Héctor, Askarpour, Hedyeh, Sherif Farouk Ahmed Hassan, Heidi, Devesa, Helena, Arbogast, Helmut, Nuñez Del Barrio, Henar, Abiyere, Henry, Delacave, Henry, Rice, Henry E., Pleass, Henry, Bradly, Hera, 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Rugambwa, Jean Paul, Jordaan, Jean- Jacques, Razafindrahita, Jeannie Ba, Do, Jee Eun, Senavirathna, Jeewantha, Kalyanapu, Jeffrey A, Chan, Jeffrey, Ofori, Jeffrey, Otote, Jeffrey, Akiely, Jehad, Cassiano Neves, Jelena, Gillingham, Jemima, Herrera Batres, Jenifer Olga María, Ezeh, Jennifer, Okei, Jennifer, Vu, Jennifer, Guevara, Jenny, Siu, Jenny, Rolinger, Jens, Skaff, Jeolle, Uys, Jernelle, Makama, Jerry Godfrey, Barklimore, Jessica, Dei-Asamoa, Jessica, Jahjah, Jessica, Jones, Jessica, Ng, Jessica, Ricardo, Jéssica, Schembri Higgans, Jessica, You, Jessica, Annan, Jessie, Aguilar, Jesus Antonio, Pizarro Lozano, Jesús, Lim, Jia Hui, Zhu, Jiang, Wang, Jianxue, Abbasy, Jibran, Ugwu, Jideofor, Rathod, Jignesh, Albalushi, Jihan, Najajra, Jinan, Fu, Jing Hui, Tefay, Joan Sia Tan, Domingues, Joana Cristina, Simoes, Joana FF, Figueiredo, Joana, Fontaínhas, Joana, Frazão, Joana, Marques Antunes, Joana, Simoes, Joana, Marx, Joanna Naemi, Dias-Ferreira, João, Fernandes, João, Mendes, João, Pinho, João, Ribeiro, João, Vaz, João, Dominguez, Joaquina, Abutu John, Job, Chen, Joe Jun Qiao, Enaholo, Joel, Alaji, Joelle, Miller, Johanna, Binder, Johannes, Daleku, John, Katogiritis, John, Khoury, John, Anyorigiya, John Noah, Reilly, John, Abebrese, John Tabiri, Ahale, Johnny Lordson, Tabora-Zepeda, Johnny, Barrutia Leonardo, Jon, Demma, Jonathan Abraham, Hong, Jonathan, Chejfec-Ciociano, Jonathan Matias, Oppong, Jonathan, Quansah, Jonathan, Sutcliffe, Jonathan, Taiwo, Jones, Nyamekye - Baidoo, Joojo, Prat-Ortells, Jordi, Dongmo, Jordy, Kleeff, Jorg, Jimenez Flores, Jorge Alberto, Pellecer Cano, Jorge Bernardo, Chóliz, Jorge, Giubi Bobeda, Jorge Eduardo, Escartin, Jorge, Febré, Jorge, Gass, Jörn-Markus, Calvache, Jose A, Guzman Barba, Jose Aldo, Gutiérrez Gómez, José Alonso, Calvache, Jose Andres, Acevedo Parrales, José Danilo, Orozco Navarro, José Esteban, Viñas, José Federico, Gomez, José, Goncalves-Nobre, Jose Guilherme, Valenzuela, José Ignacio, Garcia Galocha, Jose Luis, 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Marcella, Pisano, Marcello, Doniquian, Marcelo Alejandro, Martínez Bareiro, Marcelo Nicolás, Pagani, Marcelo, Scortechini, Marcelo, Carvalho, Márcia, Sánchez Audelo, Marco Antonio, Brizzolari, Marco, Ceresoli, Marco, De Prizio, Marco, Amisano, Marco Francesco, Gramellini, Marco, Marcianò, Marco, Mariani, Marco, Milone, Marco, Montagna, Marco, Piccino, Marco, Santos, Marco, Dyer, Marcus, Kang, Marcus, Mahadi, Mardhiana, Zawadzki, Marek, Yinusa, Margaret, Bernardo, Margarida, Nunes Luís, Margarida, Gambelli, Margherita, Flint, Margot, Aggelidou, Maria, Bequis, Maria Agustina, Sotiriou, Maria Aikaterini, Ñañez, Maria Alejandra, Tahir, Maria Ambreen, Gascón Domínguez, María Ángeles, Asimakidou, Maria, Mourato, Maria Beatriz, Blanco, Maria, Christou, Maria, Coronas Soucheiron, Maria, Pignanelli, Maria Costanza, Kalaydjian, María Cristina, Martí-Ejarque, Maria del Mar, Olmedo Reinoso, María Del Mar, Cebollero, María Del Pilar, Derattani, Maria, Gama Caldeira, Maria Do Carmo, Drogouti, Maria, Gonzalez-Gonzalez, Maria Elena, Muñoz Fernández, María Elena, Muriel, María Emilia, Duran, María Eugenia, Zarate Casas, María Fernanda, Florou, Maria, Piacentini, Maria Gaia, Seixo, Maria Inês, Bellini, Maria Irene, Peña Soria, Maria Jesús, Martínez, María José, Medina, Maria José, Rueda Medécigo, María José, Karakeke, Maria, Kausar, Maria, Kyriazi, Maria, Marqueta De Salas, Maria, Modolo, Maria Marta, Mateu, Maria, Mavri, Maria, El Ghoul Miliotou, Maria Melina, Moreno Gijon, Maria, Papadoliopoulou, Maria, Proclamà, Maria Pia, Picciochi, Maria, Reis, Maria, Rennis, Maria, D'Anna, Maria Rosa, Ruffoli, Maria, Ruiz Soriano, María, Sánchez Ramirez, Maria, Sánchez-Rubio, María, Schüler, Maria, Sotiropoulou, Maria, Barrio Renteria, Maria Teresa, Tsopozidi, Maria, Vasconcelos, Maria, Facchino, Maria Vittoria, Wikar, Maria, Aguilera-Arevalo, Maria-Lorena, Abdu, Mariam, Asarbakhsh, Mariam, Elmiesiry, Mariam, Ashong, Marian Esi, Gomes, Mariana, Capuano, Marianna, Lill, Marianne, Nieto Galvan, 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Nathan, Michael, Maclean, Michael, Nortey, Michael, Pellen, Michael, Pham, Michael, Pitiakoudis, Michael, Singh, Michael Prodip, Spartalis, Michael, Van Der Colf, Michael, Wilson, Michael, Billis, Michail, Karanikas, Michail, Papamichail, Michail, Vailas, Michail, Kisielewski, Michał, Kusiński, Michał, Nycz, Michał, Święch, Michał, Fagbayimu, Micheal, Adamina, Michel, Fiogbe, Michel, Prudhomme, Michel, Angelucci, Michela, Campanelli, Michela, Cricrì, Michele, Grande, Michele, Manigrasso, Michele, Scopelliti, Michele, George, Michelle, Mozel, Michelle, Galasyuk, Mick, Chevallay, Mickael, Giuliano, Micol, Dobón Rascón, Miguel Ángel, Fernandez Romero, Miguel Angel, García Ureña, Miguel Ángel, Zaragoza Mendieta, Miguel Ángel, Bejarano Serrano, Miguel, Brito, Miguel, Calderon, Miguel, Jurado Román, Miguel, Palas, Miguel, Li Valencia, Miguel Roberto, Sebastián-Mendoza, Miguel-Julián, Muresan, Mihai-Stefan, Slavchev, Mihail, Agapov, Mikhail, Milentijević, Milica, Catterall, Millie, 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Abosedra, Mohammed, Sarker, Mohammed Abu Kawsar, Abudabbous, Mohammed, Abuwarda, Mohammed, Elgak, Mohammed Ahmed, Al Hinai, Mohammed, Al Zebda, Mohammed, Al-Shehari, Mohammed, Alharthi, Mohammed, Ali, Mohammed, Ismael Alamin, Mohammed Ali, Alqadasi, Mohammed, Alshanwani, Mohammed, Alshehri, Mohammed, Asaad, Mohammed, Bashir, Mohammed, Bohlala, Mohammed, Meghaizerou, Mohammed El Amine, Albanna, Mohammed Emad Hashem, Ghunaim, Mohammed, Goga, Mohammed, Hajhamad, Mohammed, Hamada Takrouney, Mohammed, Hammoda, Mohammed, Hamoud Almahly, Mohammed, Muragi, Mohammed, Mohammed, Mohammed Mustafa Hassan, Obaid, Mohammed, Omar, Mohammed, Said, Mohammed, Salah, Mohammed, Saleh Khatab, Mohammed, Aliyu, Mohammed Salele, Shakhshir, Mohammed, Sheriff, Mohammed, Tageldin, Mohammed, Abdelfattah, Mohanad, Daher, Mohanad, Lotfy, Mohanad, Alqedrh, Mohannad, Nasani, Mohannad, Mohd Shah, Mohd Shahrulsalam, Madany, Mohie El-Din Mostafa, Mobolaji-Ojibara, Mojisola, Nkogatse, Moleseng, Alazabi, Mona, Gupta, 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Mamduh, Samah, Omar, Samah, Altaf, Saman, Dos Santos Rocha Ferreira, Samantha, Quoy, Samantha, Emile, Sameh, Abu Salem, Samer, Al Athath, Samer, Yigman, Samet, Eldirdiri, Sami, Imam, Sami, Jomaa, Sami, Errami, Samia, Kessab, Samia, Muhammad, Saminu, Delibegovic, Samir, Kanaan, Samir, Aliozor, Sampson, Olori, Samson, Sani, Samuel Ali, Anim, Samuel, Bennett, Samuel, Debrah, Samuel, Ghattas, Samuel, Brenu, Samuel Gyasi, Robinson, Samuel James Alexander, Arthur, Samuel Joseph, Mcclintock, Samuel, Mensah, Samuel, Ogunlade, Samuel, Tingle, Samuel, Jabeen, Sana, Borrego Canovaca, Sandra, De La Cruz Ahufinger, Sandra, Tsoti, Sandra Maria, Paterna -Lopez, Sandra, Sanz, Sandra, Tsatsu, Sandra, Hügli, Sandro, Yunusa, Sani Abdullahi, Aji, Sani Ali, Katragadda, Sanjay, Edem, Sanketh, Irrinki, Santhosh, Shivashankar Chikkanayakanahalli, Santhosh, Bertone, Santiago, Karmarkar, Santosh, Abbas, Sara, Alashhab, Sara, Alsaeiti, Sara, Andrade, Sara, Egreara, Sara, Elfallah, Sara, Galati, Sara, García López, Sara, Giovampietro, Sara, Ismail, Sara, Kamari, Sara, Lauricella, Sara, Marzorati, Sara, Mohammed, Sara, Moschella, Sara, Mostafa Yassin, Sara, Patrocínio, Sara, Massa, Sara Tiziana, Vertaldi, Sara, Abdelmohsen, Sarah, Al Sharie, Sarah, Barbosa Castelo Branco, Sarah, Bowman, Sarah, Condron, Sarah, Elfurdag, Sarah, Ellouzy, Sarah, Fennelly, Sarah, Mansour, Sarah, Molfino, Sarah, Qwyder, Sarah, Rennie, Sarah, Robinson, Sarah, Segnitome, Sarah, Staight, Sarah, Yassin, Sarah, Alsibai, Sareyah, Khan, Sarfaraz, Khurana, Sarita, Rafiq, Sarmad, Malhi, Sarvpreet Singh, Dognia, Satchmo, D A, Sathiafrey, Babu, Satia, Subbiah Nagaraj, Satish, Meena, Satya Prakash, Vasquez, Saul, Bradulskis, Saulius, Mikalauskas, Saulius, Laura, Saura García, Verhage, Savannah Skye, Simeonidis, Savvas, Sarwary, Sayed Haschmatullah, Naidu, Sayuri, Schimpke, Scott, Davis, Sean, Stevens, Sean, Sierra, Sebastian, Dos Santos, Sebastiano, Strachan, Sebastien, Bektas, Sebnem, Atupra, Sedinam Adjoa Asiedua, Kreid, Sedra, Bugren, Seeraj, Saudí-Moro, Sef, Ashini, Sehar, Aboseif, Seif, Abdul Rahman, Seif-Aldin, Karim, Seiver, Öztürk, Selen, Akuffo, Selma, Awad, Selmy, Srishankar, Selvaratnam, Tobome, Sèmèvo Romaric, Malek, Sepand, Quartarone, Serafino, Grimaldi, Serena, Guarriello, Serena, Kalenga, Serge, Katorkin, Sergei, Trujillo Ponce, Sergio Adrian, Villeda, Sergio Alejandro, Intini, Sergio Giuseppe, Vázquez-Sánchez, Sergio Jiram, Salido, Sergio, Valeri, Sergio, Yilmaz, Serhan, Meriç, Serhat, Bensalem, Serien, Sucu, Serkan, Yılmaz, Serkan, Uludağ, Server Sezgin, Torres Rodríguez, Servio Tulio, Ooi, Sett, Luciano, Severino, Houndji, Sèwou Francklin Albert, Agordjor, Seyram, Ward, Sezar, Samardali, Shaden, Altoume, Shadi, Mahfoud, Shafik, Razaq, Shahad, Khan, Shahbano, Husanov, Shahboz, Ahmed, Shaheer, Islam, Shahnoor, Waqar, Shahzad Hussain, Kumaran, Shairashree, Magrhi, Shamsa, Zhang, Shane, Kashyap, Shankarsai, Karandikar, Sharad, Sundaramurthy, Sharada, Chowdhury, Sharfuddin, Jayasekara, Sharitha, Laura, Sharon, Shanker, Shashwat, Ababneh, Shatha, Gilbert, Shaun, Kenworthy, Shaunna, Ng, Shawn Hong Ming, Mackenzie, Shawn, Salindera, Shehnarz, Khattak, Shehrbano, Loke, Sheih Nee, Manzoor, Sheikh Viqar, Alwardi, Sheikha, Allam, Shereen, Tawfik, Sherifa, Francis, Shikha, Cai, Shirley, Dindyal, Shiva, Pandya, Shivangi, Chopra, Shreya, Ingley, Shreya, Kulkarni, Shrirang, Kosna, Shuba, Nayak, Shubhalaxmi, Ahuja, Shubham, Hariharan, Shubhang, Karuppusamy Krishnasamy, Shyam, Khare, Siddhant, Handa, Siddhartha, Amin Omar Alsiddig, Siddig, Alqurashi, Siddiga, Al-Tahayneh, Sief-Addeen, Sibiya, Silindokuhle, Perretta, Silvana, Ibarra Camargo, Silvia Alejandra, Montisci, Silvia, Mungo, Silvia, Puddu, Silvia, Severi, Silvia, Agudelo Mendoza, Silvia Valentina, Makkai-Popa, Silviu Tiberiu, Boyes, Simon, Monkhouse, Simon, Stock, simon, Alberti, Simona, Meneghini, Simona, Giudici, Simone, Guadagni, Simone, Birolo, Simone Lorenzo, Novello, Simone, Oliveira, Simone, Gumede, Simphiwe, Dhole, Simran, Budhwani, Simran Saleem, Ramjit, Sinead, Yumurtacilar, Sinem, Mahendra, Sirigi Naga, Abeykoon, Sithira, Moh Pauzi, Siti Farhan, Rajendra, Sittampalam, Sundararajan, Siva, Gananadha, Sivakumar, Kamarajah, Sivesh K, Marawu, Siyasanga, Basu, Sk, Hassan, Sleman, Reddy, Snigdha Mettu, Anaya Sanchez, Sofia, Gaspar Reis, Sofia, Gomez, Sofía, Gamba, Sofia Lucia, Pimentel Morais, Sofia, Ashry, Soha, Abdullateef, Sohaila, Bandyopadhyay, Soham, Samadi, Soheil, Pathan, Sohilkhan R., Lakew, Solomon, Basu, Somprakas, Ohri, Sonali, Alonso Marcos, Sonia, Amoza Pais, Sonia, Fortuna Martins, Sónia, Gill, Sonia, Matthiess, Sonia, Sabbatini, Sonia, Soto Schütte, Sonia, Engel, Sophie, Eam, Sothseyhakmonique, Botaitis, Sotirios, Lawani, Souliath, Jamil, Soumaya, Kondpan, Sourav, Oum, Sovannarith, Govender, Sovishnee, Christodoulou, Spyridon, Davakis, Spyridon, Vernadakis, Spyridon, Gkogkos, Spyros, Gobishangar, Sreekanthan, Suresh, Sreelakshmi, Vembar, Sridhar, M, Srikanth, Abdelrasoul Elnour Ismail, Srraa, Zourntou, Stamatina-Emmanouela, Nwabuoku, Stanley Emeka, Ideh, Stanley, Charitonos, Stavria, Liapis, Stavros Chrysovalantis, Faber, Stefan, Piccioni, Stefania Angela, Romano, Stefania, Silvestre, Stefania, Jarmusch, Stefanie, Soelling, Stefanie, Cardelli, Stefano, Chaifouroosh Mamagany, Stefano, Corso, Stefano, Basso, Stefano Maria Massimiliano, Megna, Stefano, Bitsianis, Stefanos, Tsatsos, Stefanos, Morales, Steffanía, Gerdes, Stephan, Göller, Stephanie, Hanna, Stephanie, Tabiri, Stephen, Agana, Stephen, Theivendran, Stephen Arthur, Kache, Stephen, Knight, Stephen R, Smith, Stephen, Stonelake, Stephen, Wrenn, Stephen, Gopaul, Steven, Vederaki, Styliani, Kapiris, Stylianos, Kykalos, Stylianos, Hlaing, Su Su, Chia, Su Yin Denise, Abu Khousa, Suad, M. Udwan, Suad, Raul, Subrat, Chase, Suchita, Nair, Sudharrshan, Joseph, Sudhir, Singh, Sudhir Kumar, Singh, Sudhir, Timmalah, Suhaylah, Alsuwiyah, Suhir, Thalgaspitiya, Sujeewa Priyantha Bandara, Sellahewa, Sujeewa, Neogi, Sujoy, Burger, Sule, Polat, Süleyman, Alkadi, Sulman, Asiri, Sultan, Otho, Sumaira, Mewa Kinoo, Suman, Ebrahim, Sumayyah, Tontus, Sumeyya, Midya, Sumit, Thuraisamy Sarma, Sundaramoorthy Iyer, Payyanur Thotan, Sundeep, Kumar Venkatappa, Sunil, Techapongsatorn, Suphakarn, Kaur, Supreet, Jp, Supritha, Tan, Suqi, Djote, Surafel Mulatu, Surendran, Suraj, Singh, Surendra, Chilaka, Suresh, Lee, Susan, Henriques, Susana, Giridaran, Suseendirarajah, Achugatla, Sushma, Kumar, Suvam, Brincat, Svetlana, Deshpande, Swati, Batista, Sylvia, Akharaekpanya, Tachporn, Moges, Tadesse Girma, Türkmen, Taha Berkay, Alhaj Hasan, Taima, Alshawabkeh, Taima', Majed, Taima', Lawal, Taiwo Akeem, Ibiyeye, Taiye Taibat, Rashid, Tajamul, Košir Božič, Tajda, Mohammed, Tajudeen, Khewater, Talal, Abelman, Talia, Al Barhi, Tamadher, Mogne, Tamiris, Salazar-Lorenzana, Tania Abril, Akter, Tania, Gómez Sanz, Tania, Motiwala, Tanmay, Valizadeh Elizeh, Tanya, Almahdi, Tanzeel, Albushary, Tanzel Alrahman, Abdulrahman, Taofeeq, Finlay, Tara, Chouari, Tarak, Awad, Tarek, Sabra, Tarek, M. Abubasheer, Tareq, Alhusban, Tariq, Yılmaz, Tarık Emre, Aloqaili, Tasneem, Aldirawi, Tayef, Karahasanoğlu, Tayfun, Gülşen, Taygun, Jemal, Tebarek, Nadeem, Tehmina, Singh, Tejinder Paul, Alinger, Temsula, Longkumer, Temsutoshi, Lo, Terence, Gimenez Maurel, Teresa, Uprak, Tevfik Kıvılcım, Petropoulou, Thalia, Rawther, Thampi, Techapongsatorn, Thawin, Manickam, Thendral, Padioti, Theodora, Kozonis, Theodoros, Sidiropoulos, Theodoros, Tsirlis, Theodoros, Theodosopoulos, Theodosios, Hessou, Thierry Kinnongni, Uiyapat, Thitapon, Agyen, Thomas, Harris, Thomas, Hugh, Thomas J, Jorgensen, Thomas W., Theivendrampillai, Thrshegan, Pham, Thuy Vy, Branco, Tiago, Nagwamutse, Tijjani Nasiru, Tony V, Tina, Devabalan Koil, Titus, Pilia, Tiziana, Abdulmola, Tmador Mahmed Ali, Oyeyemi, Tobiloba, Kebede, Tolera, Ibarra-Hurtado, Tomás Ramón, Reichelt, Tomas, Gach, Tomasz, Stefura, Tomasz, Wojewoda, Tomasz, Soric, Tomislav, Risteski, Toni, Tridip, Tridip Dutta Baruah, Yotsov, Tsanko, Doma Bhutia, Tshering, Girma, Tsion, Kwan, Tsun Yu, Ivanov, Tsvetomir, Iahmo, TT, Ashkar, Tuleen, Mabogoane, Tumi, Olobatoke, Tunde, Sholadoye, Tunde T., Mishra, Tushar Subhadarshan, Parker, Tyla, Ezomike, Uchechukwu, Dilibe, Uchenna, Kumbhar, Uday, Una, Uduak-Abasi, Grossi, Ugo, Ezidiegwu, Ugochukwu, Edith, Ugwuoke, Daspal, Ujjwal, Kalu, Ukoha Agwu, Dietz, Ulrich, Ronellenfitsch, Ulrich, Wirth, Ulrich, Abdullah, Umar, Rivolta, Umberto, Jayarajah, Umesh, Kanyan Kassim, Umu-Hera, Govindan, Unnikrishnan, Fernandes, Urânia, Akram, Usman, Mohammed Bello, Usman, Omara, Usra, Naidoo, Uvarasen, Mahendravarman, Vaishnaivy, Negoita, Valentina Madalina, Mariottini, Valentina, Murzi, Valentina, Zucchini, Valentina, Agbakwuru, Valentine, Armenta Tapia, Valeria Estefania, Gentilino, Valerio, Borgogni, Vanessa, Ng, Vanessa, Wolfschluckner, Vanessa, Silvestri, Vania, Žufić, Vanja, Gunasaegaram, Varman, Kamalathevan, Vasan, Pillay, Vasanthan, Neykov, Vasil, Kalles, Vasileios, Mousafeiris, Vasileios, Papadopoulos, Vasileios, Tsaousis, Vasileios, Tselepidis, Vasileios, Vougas, Vasileios, Georgilaki, Vasiliki, Nikolaou, Vasiliki, Themelidi, Vasiliki, Manchev, Vassil, Ioannou, Veatriki, Jha, Vedant Shekhar, Dragisic, Vedran, Sutharshan, Vengadasalam, Alonso, Veronica, Brocco, Veronica, Ongil Rodríguez, Verónica, Schirinzi, Veronica, Budyakova, Veronika, Naunova, Vesna, Panduro-Correa, Vicky, Ruiz López, Víctor Andrés, Bill, Victor, Dassah, Victor, Gonzabay, Víctor Eduardo, Etwire, Victor, Modekwe, Victor, Serna-Alarcon, Victor, De Donato, Victor Ugo, Duque Mallén, Victoria, Liu, Victoria, Sharma, Vidushi, Kumar, Vijaya, Muralidharan, Vijayaragavan, Kakotkin, Viktor, Enemuo, Vincent, Kudoh, Vincent, Osoka, Vincent, Siepaal, Vincent, Granata, Vincenza, Dinuzzi, Vincenza Paola, Lizzi, Vincenzo, Ricchiuti, Vincenzo, Mosca, Vinicio, Kanna D, Vinoth, Nair, Vipin Venugopal, Ledda, Virginia, Michael, Vishal, Singh, Vishavdeep, Govindasamy, Vishendran, Kollengode, Viswanathan V, Giordano, Vittoria, Morinelli, Vittoria, Lin, Vivian, Cuk, Vladica, Cijan, Vladimir, Çalik, Volkan, Bakshi, Vrushank, Ten, Vyacheslav, Ratheesh, Vysakh, Alsado, Wael, Mayo, Wafik, Yang, Wah, Rehman, Wajeeh Ur, Abbas, Walaa, Al-Khyatt, Waleed, Mabood, Waleed, Santucci, Walter, Yew, Wan Ting, Tahir, Warda, De Silva, Warusha Dhammika Dulantha, Wijenayake, Wasantha, Almadhoun, Waseem J.N., Alhroub, Wasef, Ebrahim, Wesam, Jabłoński, Wiktor, Krawczyk, Wiktor, Bhatti, William, Lai, William Kwan Ho, Petrushnko, Wilson, Afedo, Wisdom, Kasetsermwiriya, Wisit, Serednicki, Wojciech, Wysocki, Wojciech, Zerefa, Wondwossen Amtataw, Vagena, Xanthoula, Tarrado, Xavier, Papazarkadas, Xenofon, Po, Xiang Yuen, Ouadi, Yacine, Myla, Yacob, Haido, Yacoub, Hasan, Yafea, Karataş, Yağmur, Carpio Colmenares, Yahaira, Galvañ Félix, Yaiza, Balogun, Yakub Lekan, Maktabi, Yaman, Nerabani, Yaman, Fulgence, Yamuremye, De Silva, Yannick, Asar, Yara, Samer Morsy, Yara, Ghaleb, Yasameen Saif Saeed Mohammed, Vashishth, Yash, M S, Yashas, Manickchund, Yashoda, Sakaray, Yashwant, Kara, Yasin, Tosun, Yasin, Zwain, Yasir, Farag, Yasmeen, Jedidi, Yasmine, Seada, Yasmine, Aldebasi, Yasser, Ashour, Yasser, Badr, Yassin, Sarpong, Yaw, Alawneh, Yazan, Aung, Yee Lay, Orabi, Yehia, Lam, Yick Ho, Şen, Yigit Kaan, Koyluoglu, Yilmaz Onat, Huang, Yining, Mintz, Yoav, Perez, Yocarli, Chamara, Yohan, Melkamu, Yohannes, Maestre González, Yolanda, Dean, Yomna, Metaferia, Yonas Yilma, Malki, Yosra, Mohamed, Younis, A. Omar, Yousef, Alhammoud, Yousef, Allaoua, Yousef, Tanas, Yousef, El Okazy, Youssef, Kerolous, Youssef, Mohamed, Youssef, Al-Junaidi, Youssuf, Lakdawala, Yousuf, Lu, Yuann, Asano, Yukio, Altinel, Yuksel, Aktimur, Yunus Emre, Fishman, Yuri, Kudryavcev, Yurii, Tandoğan, Yusuf Iskender, Razafimandimby, Yves Michaël, Adofo-Asamoah, Yvonne, Şenol, Zafer, Odeh, Zahra, Benamrouche, Zahra Rayane, Alkhaier, Zahraa, Al-Sheikh Ali, Zaid, Zaher, Zain Aldin, Alnajjar, Zaina, Al-Balushi, Zainab, Alkhuzaie, Zainab, Khraim, Zakaria, Toutounji, Zakaria, Djama, Zakarya, Farraj, Zamil, Shah, Zamir Ahmad, Khan, Zara, Khan, Zarnigar, Abo Alarous, Zayn Alabden, Asaad, Zaynab, Demetrashvili, Zaza, Lorenc, Zbigniew, Brekalo, Zdrinko, Hannouneh, Zein Alabdin, Robertson, Zelda, Bady, Zeyad, Durna, Zeynep, Wong, Zhen Yu, Fozo, Zien Alabdin, Klib, Zienab, Chin, Ziling, Tamou, Zime Farid, Johnson, Zina, Shabello, Ziyad, Orzeszko, Zofia, Aljalabi, Zohal, Al-Azher El-Hamel, Zohour, Karampotaki, Zoi Rafaila, Valera Sanchez, Zoraida, Matkovic, Zoran, Azhar, Zubair, Qureshi, Zubaria, Correa López, Zulema Margarita, Balciscueta, Zutoia, Musilová, Zuzana, Katusic, Zvonimir, Osama, Zyad, and Dauksa, Zygimantas
- Published
- 2024
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29. Correction: Surgeons’ perspectives on artificial intelligence to support clinical decision-making in trauma and emergency contexts: results from an international survey
- Author
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Cobianchi, Lorenzo, Piccolo, Daniele, Dal Mas, Francesca, Agnoletti, Vanni, Ansaloni, Luca, Balch, Jeremy, Biffl, Walter, Butturini, Giovanni, Catena, Fausto, Coccolini, Federico, Denicolai, Stefano, De Simone, Belinda, Frigerio, Isabella, Fugazzola, Paola, Marseglia, Gianluigi, Marseglia, Giuseppe Roberto, Martellucci, Jacopo, Modenese, Mirko, Previtali, Pietro, Ruta, Federico, Venturi, Alessandro, Kaafarani, Haytham M., and Loftus, Tyler J.
- Published
- 2023
- Full Text
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30. Surgeons’ perspectives on artificial intelligence to support clinical decision-making in trauma and emergency contexts: results from an international survey
- Author
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Cobianchi, Lorenzo, Piccolo, Daniele, Dal Mas, Francesca, Agnoletti, Vanni, Ansaloni, Luca, Balch, Jeremy, Biffl, Walter, Butturini, Giovanni, Catena, Fausto, Coccolini, Federico, Denicolai, Stefano, De Simone, Belinda, Frigerio, Isabella, Fugazzola, Paola, Marseglia, Gianluigi, Marseglia, Giuseppe Roberto, Martellucci, Jacopo, Modenese, Mirko, Previtali, Pietro, Ruta, Federico, Venturi, Alessandro, Kaafarani, Haytham M., and Loftus, Tyler J.
- Published
- 2023
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31. Time for a paradigm shift in shared decision-making in trauma and emergency surgery? Results from an international survey
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Cobianchi, Lorenzo, Dal Mas, Francesca, Agnoletti, Vanni, Ansaloni, Luca, Biffl, Walter, Butturini, Giovanni, Campostrini, Stefano, Catena, Fausto, Denicolai, Stefano, Fugazzola, Paola, Martellucci, Jacopo, Massaro, Maurizio, Previtali, Pietro, Ruta, Federico, Venturi, Alessandro, Woltz, Sarah, Kaafarani, Haytham M., and Loftus, Tyler J.
- Published
- 2023
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32. A case study of impacts of an extreme weather system on the Mediterranean Sea circulation features: Medicane Apollo (2021)
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Menna, Milena, Martellucci, Riccardo, Reale, Marco, Cossarini, Gianpiero, Salon, Stefano, Notarstefano, Giulio, Mauri, Elena, Poulain, Pierre-Marie, Gallo, Antonella, and Solidoro, Cosimo
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- 2023
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33. Tumor necrosis factor receptor‐1 is selectively sequestered into Schwann cell extracellular vesicles where it functions as a TNFα decoy
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Sadri, Mahrou, Hirosawa, Naoya, Le, Jasmine, Romero, Haylie, Martellucci, Stefano, Kwon, Hyo Jun, Pizzo, Donald, Ohtori, Seiji, Gonias, Steven L, and Campana, Wendy M
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Biomedical and Clinical Sciences ,Neurosciences ,Rare Diseases ,Clinical Research ,Biotechnology ,Cells ,Cultured ,Extracellular Vesicles ,Receptors ,Tumor Necrosis Factor ,Type I ,Receptors ,Tumor Necrosis Factor ,Type II ,Schwann Cells ,Tumor Necrosis Factor-alpha ,extracellular vesicles ,neuropathic pain ,peripheral nerve injury ,Schwann cells ,TNF Receptor-1 ,TNF alpha ,TNFα ,Neurology & Neurosurgery - Abstract
Schwann cells (SCs) are known to produce extracellular vesicles (EV) that participate in cell-cell communication by transferring cargo to target cells, including mRNAs, microRNAs, and biologically active proteins. Herein, we report a novel mechanism whereby SC EVs may regulate PNS physiology, especially in injury, by controlling the activity of TNFα. SCs actively sequester tumor necrosis factor receptor-1 (TNFR1) into EVs at high density, accounting for about 2% of the total protein in SC EVs (~1000 copies TNFR1/EV). Although TNFR2 was robustly expressed by SCs in culture, TNFR2 was excluded from SC EVs. SC EV TNFR1 bound TNFα, decreasing the concentration of free TNFα available to bind to cells and thus served as a TNFα decoy. SC EV TNFR1 significantly inhibited TNFα-induced p38 MAPK phosphorylation in cultured SCs. When TNFR1 was proteolytically removed from SC EVs using tumor necrosis factor-α converting enzyme (TACE) or neutralized with antibody, the ability of TNFα to activate p38 MAPK in the presence of these EVs was restored. As further evidence of its decoy activity, SC EV TNFR1 modified TNFα activities in vitro including: (1) regulation of expression of other cytokines; (2) effects on SC morphology; and (3) effects on SC viability. SC EVs also modified the effects of TNFα on sciatic nerve morphology and neuropathic pain-related behavior in vivo. By sequestering TNFR1 in EVs, SCs may buffer against the potentially toxic effects of TNFα. SC EVs provide a novel mechanism for the spatial and temporal regulation of neuro-inflammation.
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- 2022
34. A 36-year-old man, body builder presenting with unexpected severe anemia
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Molfino, Alessio, Martellucci, Ottavio, Melena, Michele, Assanto, Eleonora, Giovannetti, Antonello, and Muscaritoli, Maurizio
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- 2023
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35. Impaired Vestibulo-Ocular Reflex on Video Head Impulse Test in Superior Canal Dehiscence: 'Spontaneous Plugging' or Endolymphatic Flow Dissipation?
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Andrea Castellucci, Pasquale Malara, Salvatore Martellucci, Mohamad Alfarghal, Cristina Brandolini, Gianluca Piras, Enrico Armato, Rosanna Rita Ruberto, Pasquale Brizzi, Livio Presutti, and Angelo Ghidini
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superior canal dehiscence ,vestibulo-ocular reflex ,third window ,plugging ,video head impulse test ,vestibular-evoked myogenic potentials ,Otorhinolaryngology ,RF1-547 - Abstract
Surgical plugging of the superior semicircular canal (SSC) represents an effective procedure to treat disabling symptoms in superior canal dehiscence (SCD), despite resulting in an impaired vestibulo-ocular reflex (VOR) gain for the SSC. On the other hand, SSC hypofunction on video head impulse test (vHIT) represents a common finding in patients with SCD exhibiting sound/pressure-induced vertigo, a low-frequency air–bone gap (ABG), and enhanced vestibular-evoked myogenic potentials (VEMPs). “Spontaneous canal plugging” has been assumed as the underlying process. Nevertheless, missing/mitigated symptoms and/or near-normal instrumental findings would be expected. An endolymphatic flow dissipation has been recently proposed as an alternative pathomechanism for SSC VOR gain reduction in SCD. We aimed to shed light on this debate by comparing instrumental findings from 46 ears of 44 patients with SCD exhibiting SSC hypofunction with post-operative data from 10 ears of 10 patients with SCD who underwent surgical plugging. While no difference in SSC VOR gain values was found between the two groups (p = 0.199), operated ears developed a posterior canal hypofunction (p = 0.002). Moreover, both ABG values (p = 0.012) and cervical/ocular VEMP amplitudes (p < 0.001) were significantly higher and VEMP thresholds were significantly lower (p < 0.001) in ears with SCD compared to operated ears. According to our data, canal VOR gain reduction in SCD should be considered as an additional sign of a third window mechanism, likely due to an endolymphatic flow dissipation.
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- 2023
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36. Robot-assisted pelvic floor reconstructive surgery: an international Delphi study of expert users
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Simoncini, Tommaso, Panattoni, Andrea, Aktas, Mustafa, Ampe, Jozef, Betschart, Cornelia, Bloemendaal, Alexander L. A., Buse, Stephan, Campagna, Giuseppe, Caretto, Marta, Cervigni, Mauro, Consten, Esther C. J., Davila, Hugo H., Dubuisson, Jean, Espin-Basany, Eloy, Fabiani, Bernardina, Faucheron, Jean-Luc, Giannini, Andrea, Gurland, Brooke, Hahnloser, Dieter, Joukhadar, Ralf, Mannella, Paolo, Mereu, Liliana, Martellucci, Jacopo, Meurette, Guillaume, Montt Guevara, Maria Magdalena, Ratto, Carlo, O’Reilly, Barry A., Reisenauer, Christl, Russo, Eleonora, Schraffordt Koops, Steven, Siddiqi, Shahab, Sturiale, Alessandro, and Naldini, Gabriele
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- 2023
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37. Transanal irrigation in functional bowel disorders and LARS: short-term results from an Italian national study
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Falletto, E., Martellucci, J., Rossitti, P., Bondurri, A., Zaffaroni, G., Ascanelli, S., Chimisso, L., Lauretta, A., Mirafiori, M., Clementi, I., Ripetti, V., Lufarelli, P., Cestaro, G., Bottini, C., Bellini, M., Lambiase, C., Di Candido, F., Zattoni, D., Cornaglia, S., Tonello, P., and Zucchi, E.
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- 2023
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38. Prions and Neurodegenerative Diseases: A Focus on Alzheimer's Disease.
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Crestini, Alessio, Santilli, Francesca, Martellucci, Stefano, Carbone, Elena, Sorice, Maurizio, Piscopo, Paola, and Mattei, Vincenzo
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Biomedical and Clinical Sciences ,Biological Psychology ,Clinical Sciences ,Neurosciences ,Psychology ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Brain Disorders ,Aging ,Neurodegenerative ,Infectious Diseases ,Dementia ,Alzheimer's Disease ,Transmissible Spongiform Encephalopathy (TSE) ,Acquired Cognitive Impairment ,Emerging Infectious Diseases ,Rare Diseases ,Aetiology ,2.1 Biological and endogenous factors ,Neurological ,Alzheimer Disease ,Amyloid beta-Peptides ,Animals ,Humans ,Neurofibrillary Tangles ,Neurons ,Prion Proteins ,Protein Aggregation ,Pathological ,Randomized Controlled Trials as Topic ,Receptor ,Metabotropic Glutamate 5 ,alpha-Synuclein ,tau Proteins ,Alzheimer's disease ,A beta oligomers ,amyloid-beta ,amyloid-beta protein precursor ,neurodegenerative diseases ,prion protein ,prion protein refolding ,prions ,tau pathologies A beta O-induced signal cascade ,Alzheimer’s disease ,Aβ oligomers ,amyloid-β ,amyloid-β protein precursor ,tau pathologies AβO-induced signal cascade ,Cognitive Sciences ,Neurology & Neurosurgery ,Clinical sciences ,Biological psychology - Abstract
Specific protein misfolding and aggregation are mechanisms underlying various neurodegenerative diseases such as prion disease and Alzheimer's disease (AD). The misfolded proteins are involved in prions, amyloid-β (Aβ), tau, and α-synuclein disorders; they share common structural, biological, and biochemical characteristics, as well as similar mechanisms of aggregation and self-propagation. Pathological features of AD include the appearance of plaques consisting of deposition of protein Aβ and neurofibrillary tangles formed by the hyperphosphorylated tau protein. Although it is not clear how protein aggregation leads to AD, we are learning that the cellular prion protein (PrPC) plays an important role in the pathogenesis of AD. Herein, we first examined the pathogenesis of prion and AD with a focus on the contribution of PrPC to the development of AD. We analyzed the mechanisms that lead to the formation of a high affinity bond between Aβ oligomers (AβOs) and PrPC. Also, we studied the role of PrPC as an AβO receptor that initiates an AβO-induced signal cascade involving mGluR5, Fyn, Pyk2, and eEF2K linking Aβ and tau pathologies, resulting in the death of neurons in the central nervous system. Finally, we have described how the PrPC-AβOs interaction can be used as a new potential therapeutic target for the treatment of PrPC-dependent AD.
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- 2022
39. Anti-Inflammatory Activity of a CB2 Selective Cannabinoid Receptor Agonist: Signaling and Cytokines Release in Blood Mononuclear Cells
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Capozzi, Antonella, Caissutti, Daniela, Mattei, Vincenzo, Gado, Francesca, Martellucci, Stefano, Longo, Agostina, Recalchi, Serena, Manganelli, Valeria, Riitano, Gloria, Garofalo, Tina, Sorice, Maurizio, Manera, Clementina, and Misasi, Roberta
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Medicinal and Biomolecular Chemistry ,Organic Chemistry ,Chemical Sciences ,Clinical Research ,Aetiology ,5.1 Pharmaceuticals ,Development of treatments and therapeutic interventions ,2.1 Biological and endogenous factors ,Animals ,Anti-Inflammatory Agents ,Apoptosis ,Cannabinoid Receptor Agonists ,Cell Line ,Tumor ,Cell Proliferation ,Cell Survival ,Cells ,Cultured ,Cytokines ,Humans ,Inflammation Mediators ,Leukocytes ,Mononuclear ,Mitogen-Activated Protein Kinase 1 ,Mitogen-Activated Protein Kinase 3 ,Molecular Structure ,Phosphorylation ,Receptor ,Cannabinoid ,CB2 ,Signal Transduction ,CB2R agonist ,CB2R ,immunomodulation ,anti-inflammatory activity ,Theoretical and Computational Chemistry ,Medicinal and biomolecular chemistry ,Organic chemistry - Abstract
The endocannabinoid system (ECS) exerts immunosuppressive effects, which are mostly mediated by cannabinoid receptor 2 (CBR2), whose expression on leukocytes is higher than CBR1, mainly localized in the brain. Targeted CBR2 activation could limit inflammation, avoiding CBR1-related psychoactive effects. Herein, we evaluated in vitro the biological activity of a novel, selective and high-affinity CBR2 agonist, called JT11, studying its potential CBR2-mediated anti-inflammatory effect. Trypan Blue and MTT assays were used to test the cytotoxic and anti-proliferative effect of JT11 in Jurkat cells. Its pro-apoptotic activity was investigated analyzing both cell cycle and poly PARP cleavage. Finally, we evaluated its impact on LPS-induced ERK1/2 and NF-kB-p65 activation, TNF-α, IL-1β, IL-6 and IL-8 release in peripheral blood mononuclear cells (PBMCs) from healthy donors. Selective CB2R antagonist SR144528 and CBR2 knockdown were used to further verify the selectivity of JT11. We confirmed selective CBR2 activation by JT11. JT11 regulated cell viability and proliferation through a CBR2-dependent mechanism in Jurkat cells, exhibiting a mild pro-apoptotic activity. Finally, it reduced LPS-induced ERK1/2 and NF-kB-p65 phosphorylation and pro-inflammatory cytokines release in human PBMCs, proving to possess in vitro anti-inflammatory properties. JT11 as CBR2 ligands could enhance ECS immunoregulatory activity and our results support the view that therapeutic strategies targeting CBR2 signaling could be promising for the treatment of chronic inflammatory diseases.
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- 2022
40. α1‐Antitrypsin derived SP16 peptide demonstrates efficacy in rodent models of acute and neuropathic pain
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Wang, Zixuan, Martellucci, Stefano, Van Enoo, Alicia, Austin, Dana, Gelber, Cohava, and Campana, Wendy M
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Biomedical and Clinical Sciences ,Neurosciences ,Clinical Sciences ,Neurodegenerative ,Pain Research ,Peripheral Neuropathy ,Chronic Pain ,Aetiology ,2.1 Biological and endogenous factors ,Acute Pain ,Animals ,Disease Models ,Animal ,Low Density Lipoprotein Receptor-Related Protein-1 ,MAP Kinase Signaling System ,Male ,Mice ,Neuralgia ,Neurites ,PC12 Cells ,Peptides ,Rats ,Rats ,Sprague-Dawley ,Schwann Cells ,Sensory Receptor Cells ,alpha 1-Antitrypsin ,LRP1 ,neuroinflammation ,neuropathic pain ,nociception ,peripheral nerve injury ,SP16 ,Biochemistry and Cell Biology ,Physiology ,Medical Physiology ,Biochemistry & Molecular Biology ,Biochemistry and cell biology ,Medical physiology - Abstract
SP16 is an innovative peptide derived from the carboxyl-terminus of α1-Antitrypsin (AAT), corresponding to residues 364-380, and contains recognition sequences for the low-density lipoprotein receptor-related protein-1 (LRP1). LRP1 is an endocytic and cell-signaling receptor that regulates inflammation. Deletion of Lrp1 in Schwann cells increases neuropathic pain; however, the role of LRP1 activation in nociceptive and neuropathic pain regulation remains unknown. Herein, we show that SP16 is bioactive in sensory neurons in vitro. Neurite length and regenerative gene expression were increased by SP16. In PC12 cells, SP16 activated Akt and ERK1/2 cell-signaling in an LRP1-dependent manner. When formalin was injected into mouse hind paws, to model inflammatory pain, SP16 dose-dependently attenuated nociceptive pain behaviors in the early and late phases. In a second model of acute pain using capsaicin, SP16 significantly reduced paw licking in both male and female mice (p
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- 2022
41. ATX-101, a Peptide Targeting PCNA, Has Antitumor Efficacy Alone or in Combination with Radiotherapy in Murine Models of Human Glioblastoma
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Gravina, Giovanni Luca, Colapietro, Alessandro, Mancini, Andrea, Rossetti, Alessandra, Martellucci, Stefano, Ventura, Luca, Di Franco, Martina, Marampon, Francesco, Mattei, Vincenzo, Biordi, Leda Assunta, Otterlei, Marit, and Festuccia, Claudio
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Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Cancer ,Neurosciences ,Brain Disorders ,Rare Diseases ,Brain Cancer ,Genetics ,GBM ,DNA damage signaling ,APIM-peptide ,Oncology and carcinogenesis - Abstract
Cell proliferation requires the orchestrated actions of a myriad of proteins regulating DNA replication, DNA repair and damage tolerance, and cell cycle. Proliferating cell nuclear antigen (PCNA) is a master regulator which interacts with multiple proteins functioning in these processes, and this makes PCNA an attractive target in anticancer therapies. Here, we show that a cell-penetrating peptide containing the AlkB homolog 2 PCNA-interacting motif (APIM), ATX-101, has antitumor activity in a panel of human glioblastoma multiforme (GBM) cell lines and patient-derived glioma-initiating cells (GICs). Their sensitivity to ATX-101 was not related to cellular levels of PCNA, or p53, PTEN, or MGMT status. However, ATX-101 reduced Akt/mTOR and DNA-PKcs signaling, and a correlation between high Akt activation and sensitivity for ATX-101 was found. ATX-101 increased the levels of γH2AX, DNA fragmentation, and apoptosis when combined with radiotherapy (RT). In line with the in vitro results, ATX-101 strongly reduced tumor growth in two subcutaneous xenografts and two orthotopic GBM models, both as a single agent and in combination with RT. The ability of ATX-101 to sensitize cells to RT is promising for further development of this compound for use in GBM.
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- 2022
42. Hypoxia Induces DPSC Differentiation versus a Neurogenic Phenotype by the Paracrine Mechanism
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Delle Monache, Simona, Pulcini, Fanny, Santilli, Francesca, Martellucci, Stefano, Santacroce, Costantino, Fabrizi, Jessica, Angelucci, Adriano, Sorice, Maurizio, and Mattei, Vincenzo
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Biomedical and Clinical Sciences ,Dentistry ,Stem Cell Research - Nonembryonic - Non-Human ,Stem Cell Research ,Stem Cell Research - Nonembryonic - Human ,Regenerative Medicine ,Neurosciences ,1.1 Normal biological development and functioning ,Underpinning research ,Neurological ,DPSCs ,neuronal differentiation ,hypoxia ,stem cells ,dental pulp ,Biochemistry and cell biology ,Pharmacology and pharmaceutical sciences ,Medicinal and biomolecular chemistry - Abstract
As previously described by several authors, dental pulp stem cells (DPSCs), when adequately stimulated, may acquire a neuronal-like phenotype acting as a favorable source of stem cells in the generation of nerves. Besides, it is known that hypoxia conditioning is capable of stimulating cell differentiation as well as survival and self-renewal, and that multiple growth factors, including Epidermal Growth factor (EGF) and basic fibroblast growth factor (bFGF), are often involved in the induction of the neuronal differentiation of progenitor cells. In this work, we investigated the role of hypoxia in the commitment of DPSCs into a neuronal phenotype. These cells were conditioned with hypoxia (O2 1%) for 5 and 16 days; subsequently, we analyzed the proliferation rate and morphology, and tested the cells for neural and stem markers. Moreover, we verified the possible autocrine/paracrine role of DPSCs in the induction of neural differentiation by comparing the secretome profile of the hypoxic and normoxic conditioned media (CM). Our results showed that the hypoxia-mediated DPSC differentiation was time dependent. Moreover, conditioned media (CM derived from DPSCs stimulated by hypoxia were able, in turn, to induce the neural differentiation of SH-SY5Y neuroblastoma cells and undifferentiated DPSCs. In conclusion, under the herein-mentioned conditions, hypoxia seems to favor the differentiation of DPSCs into neuron-like cells. In this way, we confirm the potential clinical utility of differentiated neuronal DPSCs, and we also suggest the even greater potential of CM-derived-hypoxic DPSCs that could more readily be used in regenerative therapies.
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- 2022
43. The Botanical Drug PBI-05204, a Supercritical CO2 Extract of Nerium Oleander, Is Synergistic With Radiotherapy in Models of Human Glioblastoma
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Colapietro, Alessandro, Yang, Peiying, Rossetti, Alessandra, Mancini, Andrea, Vitale, Flora, Chakraborty, Sharmistha, Martellucci, Stefano, Marampon, Francesco, Mattei, Vincenzo, Gravina, Giovanni Luca, Iorio, Roberto, Newman, Robert A, and Festuccia, Claudio
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Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Orphan Drug ,Cancer ,Complementary and Integrative Health ,Stem Cell Research ,Brain Cancer ,Rare Diseases ,Stem Cell Research - Nonembryonic - Human ,Clinical Research ,Neurosciences ,Biotechnology ,Brain Disorders ,Development of treatments and therapeutic interventions ,5.1 Pharmaceuticals ,Good Health and Well Being ,glioblastoma ,radiotherapy ,PBI-05204 ,apoptosis ,oleandrin ,DNA repair ,Pharmacology and Pharmaceutical Sciences ,Pharmacology and pharmaceutical sciences - Abstract
Glioblastoma multiforme (GBM) is the most common as well as one of the most malignant types of brain cancer. Despite progress in development of novel therapies for the treatment of GBM, it remains largely incurable with a poor prognosis and a very low life expectancy. Recent studies have shown that oleandrin, a unique cardiac glycoside from Nerium oleander, as well as a defined extract (PBI-05204) that contains this molecule, inhibit growth of human glioblastoma, and modulate glioblastoma patient-derived stem cell-renewal properties. Here we demonstrate that PBI-05204 treatment leads to an increase in vitro in the sensitivity of GBM cells to radiation in which the main mechanisms are the transition from autophagy to apoptosis, enhanced DNA damage and reduced DNA repair after radiotherapy (RT) administration. The combination of PBI-05204 with RT was associated with reduced tumor progression evidenced by both subcutaneous as well as orthotopic implanted GBM tumors. Collectively, these results reveal that PBI-05204 enhances antitumor activity of RT in preclinical/murine models of human GBM. Given the fact that PBI-05204 has already been examined in Phase I and II clinical trials for cancer patients, its efficacy when combined with standard-of-care radiotherapy regimens in GBM should be explored.
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- 2022
44. Author Correction: A case study of impacts of an extreme weather system on the Mediterranean Sea circulation features: Medicane Apollo (2021)
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Milena Menna, Riccardo Martellucci, Marco Reale, Gianpiero Cossarini, Stefano Salon, Giulio Notarstefano, Elena Mauri, Pierre-Marie Poulain, Antonella Gallo, and Cosimo Solidoro
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Medicine ,Science - Published
- 2024
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45. Sacral and Percutaneous Tibial Nerve Stimulation, Stem Cell Therapy, and Transanal Irrigation Device
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Naldini, Gabriele, Sturiale, Alessandro, Menconi, Claudia, Fabiani, Bernardina, Aglietti, Rebecca, Fralleone, Lisa, Annicchiarico, Alfredo, Martellucci, Jacopo, Docimo, Ludovico, editor, and Brusciano, Luigi, editor
- Published
- 2023
- Full Text
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46. Regenerative Potential of DPSCs and Revascularization: Direct, Paracrine or Autocrine Effect?
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Mattei, Vincenzo, Martellucci, Stefano, Pulcini, Fanny, Santilli, Francesca, Sorice, Maurizio, and Delle Monache, Simona
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Biological Sciences ,Regenerative Medicine ,Stem Cell Research - Nonembryonic - Human ,Stem Cell Research ,Dental/Oral and Craniofacial Disease ,Stem Cell Research - Nonembryonic - Non-Human ,1.1 Normal biological development and functioning ,Underpinning research ,Cardiovascular ,Cell Differentiation ,Dental Pulp ,Endothelial Cells ,Mesenchymal Stem Cells ,Pericytes ,Stem Cells ,Dental pulp stem cells ,Regenerative potential ,Stem cells differentiation ,Angiogenesis ,Revascularization ,Biological sciences - Abstract
A new source of mesenchymal stem cells has recently been discovered, the so-called dental pulp derived stem cells (DPSCs) which therefore could represent potentially tools for regenerative medicine. DPSC originate from the neural crest and are physiologically involved in dentin homeostasis; moreover, they contribute to bone remodeling and differentiation into several tissues including cartilage, bone, adipose and nervous tissues. DPSCs have also been shown to influence the angiogenesis process, for example through the release of secretory factors or by differentiating into vascular and/or perivascular cells. Angiogenesis, that has a pivotal role in tissue regeneration and repair, is defined as the formation of new vessels from preexisting vessels and is mediated by mutual and reciprocal interactions between endothelial cells and perivascular cells. It is also known that co-cultures of perivascular and endothelial cells (ECs) can form a vascular network in vitro and also in vivo. Since DPSCs seem to have characteristics similar to pericytes, understanding the possible mechanism of interaction between DPSCs and ECs during neo-angiogenesis is dramatically important for the development of advanced clinical application in the field of regeneration.
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- 2021
47. Correction to: Transanal irrigation in functional bowel disorders and LARS: short‑term results from an Italian national study
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Falletto, E., Martellucci, J., Rossitti, P., Bondurri, A., Zaffaroni, G., Ascanelli, S., Chimisso, L., Lauretta, A., Mirafiori, M., Clementi, I., Ripetti, V., Luffarelli, P., Cestaro, G., Bottini, C., Bellini, M., Lambiase, C., Di Candido, F., Zattoni, D., Cornaglia, S., Tonello, P., and Zucchi, E.
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- 2023
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48. Spinal tuberculosis in Afghanistan: A 2019‐2020 study of patients in Kabul hospitals
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Farah Qaderi, Idriss Mashid, Latif Gachkar, Mosè Martellucci, Shohra Qaderi, Akihiko Ozaki, Alireza Haghbin Toutounchi, Afshin Taheriazam, Takanori Asakura, Hojat Gholipoor Talemi, Noria Mohammady, and Minoosh Shabani
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Afghanistan ,back pain ,endemic ,spinal tuberculosis ,tuberculosis ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background Tuberculosis (TB) is endemic in many low‐income countries, which can affect the spine in 1%–5% of those with an active infection. This study reports the clinical characteristics of patients admitted for spinal TB in Kabul, Afghanistan, a country with very limited resources. Methods This was a descriptive study among 26 patients treated for spinal TB in three major referral hospitals in Kabul, Afghanistan, between March 2019 and April 2020. The sociodemographic and clinical details, gender, age, site of infection, presenting complaints, signs, and symptoms of the patients were retrieved from their medical records. Summary statistics were analyzed using SPSS version 20. Ethics approval was obtained from the ethics committee of Shahid Beheshti University of Medical Sciences in Tehran, Iran. Results Data were available for 26 patients with spinal TB admitted consecutively. The mean age of the sample was 38.2 years (SD 17.5), and there were 16 males and 10 females. Median time from symptom onset to hospital admission was 60 days. The most common diagnostic imaging technique used was magnetic resonance imaging (92.3%), followed by computed tomography (7.7%). The majority of the lesions involved the lumbar spine (61.4%), followed by the thoracolumbar spine (30.8%). Back pain was the most common manifestation in 21 patients (80.8%), and varying degrees of neurological impairment were found in 16 (61.5%) patients. There were no deaths among the patients up to the discharge date. Conclusions This study describes the clinical characteristics of spinal TB among patients in Kabul, Afghanistan. It is essential to strengthen preventive strategies and to improve health awareness about clinical features of spinal TB in patients with chronic back pain even in the absence of signs of TB.
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- 2023
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49. Lipid rafts mediate multilineage differentiation of human dental pulp-derived stem cells (DPSCs)
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Francesca Santilli, Jessica Fabrizi, Stefano Martellucci, Costantino Santacroce, Egidio Iorio, Maria Elena Pisanu, Mattea Chirico, Loreto Lancia, Fanny Pulcini, Valeria Manganelli, Maurizio Sorice, Simona Delle Monache, and Vincenzo Mattei
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DPSCs ,lipid rafts ,gangliosides ,osteogenic ,chondrogenic and adipogenic differentiation ,multilineage differentiation ,Biology (General) ,QH301-705.5 - Abstract
Cell outer membranes contain glycosphingolipids and protein receptors, which are integrated into glycoprotein domains, known as lipid rafts, which are involved in a variety of cellular processes, including receptor-mediated signal transduction and cellular differentiation process. In this study, we analyzed the lipidic composition of human Dental Pulp-Derived Stem Cells (DPSCs), and the role of lipid rafts during the multilineage differentiation process. The relative quantification of lipid metabolites in the organic fraction of DPSCs, performed by Nuclear Magnetic Resonance (NMR) spectroscopy, showed that mono-unsaturated fatty acids (MUFAs) were the most representative species in the total pool of acyl chains, compared to polyunsatured fatty acids (PUFAs). In addition, the stimulation of DPSCs with different culture media induces a multilineage differentiation process, determining changes in the gangliosides pattern. To understand the functional role of lipid rafts during multilineage differentiation, DPSCs were pretreated with a typical lipid raft affecting agent (MβCD). Subsequently, DPSCs were inducted to differentiate into osteoblast, chondroblast and adipoblast cells with specific media. We observed that raft-affecting agent MβCD prevented AKT activation and the expression of lineage-specific mRNA such as OSX, PPARγ2, and SOX9 during multilineage differentiation. Moreover, this compound significantly prevented the tri-lineage differentiation induced by specific stimuli, indicating that lipid raft integrity is essential for DPSCs differentiation. These results suggest that lipid rafts alteration may affect the signaling pathway activated, preventing multilineage differentiation.
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- 2023
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50. Tau oligomers accumulation sensitizes prostate cancer cells to docetaxel treatment
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Martellucci, Stefano, Clementi, Letizia, Sabetta, Samantha, Muzi, Paola, Mattei, Vincenzo, Bologna, Mauro, and Angelucci, Adriano
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Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Urologic Diseases ,Aging ,Brain Disorders ,Neurodegenerative ,Prostate Cancer ,Dementia ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Acquired Cognitive Impairment ,Alzheimer's Disease ,Cancer ,2.1 Biological and endogenous factors ,Aetiology ,Antineoplastic Agents ,Apoptosis ,Autophagy ,Cell Proliferation ,Docetaxel ,Gene Expression Regulation ,Neoplastic ,Humans ,Male ,Prostatic Neoplasms ,Protein Multimerization ,Tumor Cells ,Cultured ,tau Proteins ,Tau oligomer ,Cancer Therapy ,Mitosis ,Oncology & Carcinogenesis ,Oncology and carcinogenesis - Abstract
PurposeHuman tau is a highly dynamic, multifunctional protein expressed in different isoforms and conformers, known to modulate microtubule turnover. Tau oligomers are considered pathologic forms of the protein able to initiate specific protein accumulation diseases, called tauopathies. In our study, we investigated the potential association between autophagy and tau oligomers accumulation and its role in the response of prostate cancer cells to docetaxel.MethodsWe evaluated in vitro the expression of tau oligomers in prostate cancer cell lines, PC3 and DU145, in presence of autophagy inhibitors and investigated the role of tau oligomers accumulation in resistance to docetaxel treatment.ResultsTau protein was basally expressed in prostate cancer lines as several monomeric and oligomeric forms. The pharmacologic inhibition of autophagy induced in cancer cells the accumulation of tau protein, with a prevalent expression of oligomeric forms. Immunofluorescence analysis of untreated cells revealed that tau was visible mainly in dividing cells where it was localized on the mitotic spindle. Inhibition of autophagy determined an evident upregulation of tau signal in dividing cells and the presence of aberrant monoastral mitotic spindles. The accumulation of tau oligomers was associated with DNA DSB and increased cytotoxic effect by docetaxel.ConclusionsOur data indicate that autophagy could exert a promoting role in cancer growth and during chemotherapy facilitating degradation of tau protein and thus blocking the antimitotic effect of accumulated tau oligomers. Thus, therapeutic strategies aimed at stimulating tau oligomers formation, such as autophagy inhibition, could be an effective adjuvant in cancer therapy.
- Published
- 2021
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