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Una normale gravidanza dipende dall'interazione "bilanciata" di tre sistemi biologici: la madre, il feto e la placenta

I ermin plcentcdescrive qellcondzne anatomo-clinica in cui tutta la placenta aderisce in maniera anomala alla parete uterina risultandone difficilmente separabile al momento del parto

In a retrospective investigation performed in the department of Surgical Odontostomatology of Palermo University Polyclinic from 1997-2006, the authors examined 12 cases of cervico-facial actinomycosis, taking into consideration age range, gender distribution, predisposing factors and symptoms. In concordance with reports in literature, they found that the disease was perimandibular in 65%, they also report the diagnostic methods and therapeutic approaches used in the study.

This paper outlines the history of the Cabinet of Pathological Anathomy at the University of Palermo, describes rapidly its current status and analyzes the composition of its displays in 1859. It aims to highlight the analogies with other collections of a similar kind and to pinpoint potential actions to endorse and develop this important scientific asset.

Gli autori segnalano un caso di propria osservazione riguardante il decesso di giovane uomo, sportivo, con anamnesi familiare e patologica negativa per patologie cardiache, coinvolto in incidente stradale autonomo; la cui causa del decesso veniva inizialmente attribuita (sulla scorta della sola ispezione cadaverica effettuata dal medico del 118 intervenuto sul luogo) ai gravi effetti contusivi cerebrali connessi al trauma cranico. Il successivo esame autoptico, disposto dall’A.G., completato dagli esami di laboratorio, consentiva di individuare la sussistenza di una ampia sostituzione fibro-adiposa del miocardio del ventricolo destro, comprendete la porzione epicardica e gli strati intermedi della parete, in soggetto con riscontro positivo per alcool all’esame tossicologico di screening. Le risultanze del caso in questione confermano l’importanza delle indagini medico-legali quale presupposto fondamentale per la valutazione del nesso causale, anche talora al fine di avere contezza del determinismo dell’evento che ha avuto il suo epilogo nel decesso. Ne deriva, in definitiva, la rilevanza della disciplina medico legale, talora anche a scopo clinico-preventivo in relazione alla potenziale sussistenza di patologie sconosciute di carattere familiare.

La sindrome da rivascolarizzazione (SR) comprende un insieme di eventi metabolici ed emodinamici che insorgono in un arto rivascolarizzato dopo un periodo più o meno lungo di ischemia, caratterizzata da specifiche manifestazioni cliniche sia a livello locale che sistemico. Riportiamo qui di seguito un caso di SR occorsa in una giovane donna di anni 20 con Sindrome di Turner e tiroidite autoimmune la quale veniva sottoposta ad intervento di giuntopieloplastica sinistra Robot assistita, poiché affetta da stenosi del medesimo giunto ed idronefrosi sinistra.

Turner's syndrome is a genetic partial or complete monosomy of sexual chromosome X; therefore women affected by Turner's syndrome have 45 (XO) caryotype. In 15% of the cases Trner's syndrome is associated with cardiac congenital malformations, the most frequent anomalies are the aortic coartaction and the defect of interventricular septum. The authors introduce two cases of deceased women affected by Turner's syndrome caused by intrapericardic dissection of the ascending aorta.

Background: Eosinophilic granuloma (EG) is a clinical variant of the Langerhans cell histiocytosis (LCH) characterized by unifocal or multifocal bone lesions which predominantly affects children, adolescents, and young adults. Case Report: A case is reported of a 13-year-old Caucasian boy who presented unifocal EG in the mandible as the first clinic manifestation. Radiographic examination and skeletal scintigraphy revealed a further localization with an osteolytic lesion in the right femur. The therapeutic protocol used for the mandibular lesion included causal periodontal therapy, extraction of the compromised teeth, alveolar curettage, and intralesional injections of corticosteroids, in correspondence with femoral and mandibular bone lesions. Conclusions: Early diagnosis of LCH is considered an important factor which can improve the patient's prognosis and quality of life and also the cost-effectiveness of therapy. Dentists could play a fundamental role in the diagnosis and management of EG. The aim of the treatment is to eradicate EG lesions and provide adequate oral rehabilitation after the tooth loss. A careful multidisciplinary follow-up program is mandatory to identify any signs of local recurrence or dissemination.

BACKGROUND: The jejunal mucosa is the major site involved in celiac disease, but modifications have also been found in the gastric, rectal and esophageal mucosa. Few studies have focused on the histomorphological features of the oral mucosa in celiac disease patients. Our objectives were: (i) to assess the presence, quality and intensity of lymphocytic infiltrate in clinically healthy oral mucosa and its relation to celiac disease severity (villous height to crypt depth ratio); and (ii) to detect any other histological features connected to celiac disease. METHODS: Twenty-one untreated celiac disease patients (age range 13-68 years) with clinically healthy oral mucosa were enrolled and compared with 14 controls. Intestinal and oral biopsies were carried out and specimens were evaluated after staining with hematoxylin and eosin. RESULTS: Intra-epithelial lymphocyte B and T infiltrates of the oral mucosa were found to be similar in both groups; likewise, intensity of the lymphocytic infiltrate in the lamina propria was similar in both groups and was not related to intestinal damage; important signs of spongiosis were found to be more significantly present in celiac disease patients compared with controls (P = 0.0002). CONCLUSIONS: Our study showed that the healthy oral mucosa of untreated patients does not reflect the intestinal damage by celiac disease, but it is unexpectedly affected by spongiosis, as being detected for the first time in the literature. This latter feature could be related to gliadin ingestion and could contribute to explain the higher susceptibility of celiac disease patients to suffering from oral mucosa lesions.

Obiettivo: valutare le alterazioni dello sviluppo e della struttura dei villi conati di placente di gravidanze con ritardo di crescita fetale asimmetrico idiopatico (IUGR) tardivo. Pazienti e metodi: sono state esaminate 45 placente di pazienti con IUGR idiopatico con parto, per via vaginale o addominale, espletato dal gennaio 2001 al dicembre 2007. L’esame istologico è stato condotto secondo le linee guida del Gruppo Italiano di Anatomia Patologica. La diagnosi di IUGR è stata posta sulla base dell’evidenza clinica ed ultrasonica di ridotta crescita fetale e basso peso neonatale in associazione a riduzione del liquido amniotico e a placenta “matura” all’esame USG. Risultati: l’esame istologico ha evidenziato lesioni dello sviluppo e della struttura dei villi tipici della ipoperfusione cronica placentare così definite: maturazione accelerata dei villi (ipermaturità villare), villite ischemica (equivalente a microinfarti) ed infarti. In 10 casi, insieme a tali lesioni, ne e stata identificata un ‘altra, definita “ipercapilla-rizzazione dei villi”, che si associa ad una condizione dÏ ipossia relativa del sangue materno che circola tra i villi. Conclusioni: il ritardo di crescita intrauterino asimmetrico idiopatico può essere ricondotto ad alterazioni dell’angiogenesi e vasculogenesi che avvengono nelle fasi iniziali della gravidanza. Ciò determina una condizione di ipossia placentare con alterazioni dello sviluppo dei villi tipici della ipoperfusione cronica placentare. Objective: to evaluate the structural and developmental abnormalities of villous tissue coming from placentas of fetuses with IUGR. Patients and methods: placental examination of 45 patients with idiopathic IUGR was carried out in accordance with the guidelines of the "Gruppo Italiano di Anatomia Patologica". The diagnosis of IUGR was made on the basis of fetal growth restriction, amniotic fluid reduction and placental US imaging. Results: the placental microscopic examination showed villous alterations tipical of chronic placental ipoperfusion: ischemic villitis, accelerated villous maturity and placental infarctions. There was evidence of enhanced villous capillarization maybe due to a relative hypoxia of maternal intervillous circulating blood in ten placentas. Conclusion: asymmetric idiopathic IUGR seems to be correlated with alterations of angiogenesis in the initial pregnancy steps with resulting chronic placental ipoperfusion in late pregnancy.

Eosinophilic granuloma is a proliferation of Langerhans cells in the bones that most commonly involving the skeletal system. The disease generally affects children or young adults with predominance in males and it is characterized by a single or multiple skeletal lesions. This study describes a few cases of mandibular Eosinophilic Granuloma and the effects of surgical curettage of lesions

In a retrospective investigation performed in the department of Surgical Odontostomatology of Palermo University Polyclinic from 1997-2006, the authors examined 12 cases of cervico-facial actinomycosis, taking into consideration age range, gender distribution, predisposing factors and symptoms. In concordance with reports in literature, they found that the disease was perimandibular in 65%, they also report the diagnostic methods and therapeutic approaches used in the study

Objectives: Sjögren’s syndrome is a chronic inflammatory disease. The detection of chronic inflammatory infiltrates containing >50 lymphocytes (lymphocytic focus) per 4 mm2 tissue in minor salivary gland biopsies is a diagnostic parameter of the disease. The aim of the study was to examine if an increase in the tissue area of a single minor labial salivary gland biopsy through serial histological sections in patients affected by primary Sjögren’s syndrome could facilitate the detection of the diagnostic focus score (grades >1 or >2). Methods: We observed 24 labial salivary gland biopsies from patients affected by primary Sjögren’s syndrome, diagnosed according to the clinical-laboratory criteria proposed by the American-European Consensus Group. The analysis was carried out on sections (n= 72) obtained at three different levels at 200 micrometers from one another. The serial sections regarding the 3 levels were reviewed by the same oral pathologist, who detected both the total number of foci, and their surface, calculating a cumulative focus score. Results: No significant correlation was found between the number of lobules per histological section and the focus score (Pearson correlation 0.363, p= 0.01). No significant variation in focus score distribution was identified in the three serial histological levels at 200 micrometers from one another. From the comparison between the number of lobules observed and the focus score grade, no direct proportionality between the amount of parenchyma analyzed and the focus score was found. Conclusions: The focus score remained unchanged in the serial sections at different depths.