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3. Possibilities and limitations of forensic psychiatry services: Legislation and organization in an international and national perspective

Author

Pessina, R, Santoriello, C, Rossetto, I, Giacomo, E, Placenti, V, Pescatore, F, Colmegna, F, Babudieri, S, Celozzi, C, Lorettu, L, Lucania, L, Manzone, M, Nivoli, G, Quintavalle, G, Zanalda, E, Pagano, A, Clerici, M, Pessina R., Santoriello C., Rossetto I., Giacomo E. D., Placenti V., Pescatore F., Colmegna F., Babudieri S., Celozzi C., Lorettu L., Lucania L., Manzone M. L., Nivoli G., Quintavalle G., Zanalda E., Pagano A. M., Clerici M., Pessina, R, Santoriello, C, Rossetto, I, Giacomo, E, Placenti, V, Pescatore, F, Colmegna, F, Babudieri, S, Celozzi, C, Lorettu, L, Lucania, L, Manzone, M, Nivoli, G, Quintavalle, G, Zanalda, E, Pagano, A, Clerici, M, Pessina R., Santoriello C., Rossetto I., Giacomo E. D., Placenti V., Pescatore F., Colmegna F., Babudieri S., Celozzi C., Lorettu L., Lucania L., Manzone M. L., Nivoli G., Quintavalle G., Zanalda E., Pagano A. M., and Clerici M.

Published
2019

5. Impact of a new carrageenan-based vaginal microbicide in a female population with genital HPV-infection: First experimental results

Author

Perino A., Consiglio P., Maranto M., De Franciscis P., Marci R., Restivo V., Manzone M., Capra G., Cucinella G., Calagna G., A. PERINO, P. CONSIGLIO, M. MARANTO, P. DE FRANCISCIS, R. MARCI, V. RESTIVO, M. MANZONE, G. CAPRA, G. CUCINELLA, G. CALAGNA, Perino, A., Consiglio, P., Maranto, M., De Franciscis, P., Marci, R., Restivo, V., Manzone, M., Capra, G., Cucinella, G., and Calagna, G.

Subjects
Adult, Settore MED/07 - Microbiologia E Microbiologia Clinica, HPV, Adolescent, Socio-culturale, Microbicide, Carrageenan, Carrageenan, Papillomavirus, Microbicide, Female population, HPV, Young Adult, Anti-Infective Agents, Chondrus, Humans, Prospective Studies, Papillomaviridae, Female population, Papillomavirus Infections, Middle Aged, Papillomavirus, Seaweed, Administration, Intravaginal, Treatment Outcome, Colposcopy, Patient Satisfaction, Case-Control Studies, DNA, Viral, Vagina, Vaginal Creams, Foams, and Jellies, Female, Follow-Up Studies
Abstract

OBJECTIVE: The objective of this study was to assess safety, satisfaction, and anti- viral effect of a new carrageenan-based vaginal microbicide in a population of fertile female patients with genital human papillomavirus (HPV) infection. PATIENTS AND METHODS: Forty healthy and sexually active women aged 18-45 years with genital HPV infection were enrolled. Each subject was treated with a gel formulated with 0.02% carrageenan and Propionibacterium extract (CGP) (Carvir, Depofarma SpA, Mogliano Veneto, Treviso, Italy). The subjects were evaluated at baseline, after the I cycle of therapy and after the II cycle. At final status, treatment acceptability and satisfaction were evaluated using a 5-point Likert scale. Furthermore, the rate of HPV genital infection clearance at final follow-up was evaluated. These data were compared with the HPV genital infection clearance rate in a control group of patients not subjected to any therapy. RESULTS: Overall, 68 HPV infections were detected at baseline, among 40 subjects enrolled. The HPV 16 genotype was the most frequent (12%) followed by HPV 18 (10%), and HPV 53 (9%). At the end of the study, 22 (55%) patients were very satisfied, 14 (35%) were satisfied, 3 (7.5%) were uncertain, and only 1 (2.5%) was dissatisfied, with 0 very dissatisfied. Only 2 patients complained of a local adverse event. Analysing infection clearance at the end of the study, 60% of patients became HPV negative. Among these, 13 cases were high-risk HPV infection. There were 16 patients with persistent infection (“non-responders”). No patient developed a “de novo” genital lesion. After controlling for age, the intervention had an adjusted OR of 4.9 (95% CI 1.6-15.1) to clear HPV. CONCLUSIONS: The results of this work suggest that Carvir vulvovaginal microbicide gel is safe and well-tolerated. Furthermore, this experience supports the hypothesis that CG has a role in accelerating the normal clearance of genital HPV infection in women with a positive HPV-DNA test.

Published
2019

6. Possibilities and limitations of forensic psychiatry services: Legislation and organization in an international and national perspective

Author

Pessina R., Santoriello C., Rossetto I., Giacomo E. D., Placenti V., Pescatore F., Colmegna F., Babudieri S., Celozzi C., Lorettu L., Lucania L., Manzone M. L., Nivoli G., Quintavalle G., Zanalda E., Pagano A. M., Clerici M., Pessina, R, Santoriello, C, Rossetto, I, Giacomo, E, Placenti, V, Pescatore, F, Colmegna, F, Babudieri, S, Celozzi, C, Lorettu, L, Lucania, L, Manzone, M, Nivoli, G, Quintavalle, G, Zanalda, E, Pagano, A, and Clerici, M

Subjects
forensic psychiatry service
Published
2019

7. Possibilità e limiti dei Servizi di Psichiatria Forense: legislazione e organizzazione in un’ottica internazionale e nazionale

Author

Pessina, R, Santoriello, C, Rossetto, I, Di Giacomo, E, Placenti, V, Pescatore, F, Colmegna, F, Babudieri, S, Celozzi, C, Lorettu, L, Lucania, L, Manzone, M, Nivoli, G, Quintavalle, G, Zanalda, E, Pagano, A, Clerici, M, Manzone, ML, Pagano, AM, Pessina, R, Santoriello, C, Rossetto, I, Di Giacomo, E, Placenti, V, Pescatore, F, Colmegna, F, Babudieri, S, Celozzi, C, Lorettu, L, Lucania, L, Manzone, M, Nivoli, G, Quintavalle, G, Zanalda, E, Pagano, A, Clerici, M, Manzone, ML, and Pagano, AM

Published
2019

8. Il sistema REMS nella realtà italiana: autori di reato, disturbi mentali e PDTA

Author

Rivellini, G, Pessina, R, Pagano, A, Giordano, S, Santoriello, C, Rossetto, I, Babudieri, S, Celozzi, C, Lucania, L, Manzone, M, Nivoli, G, Quintavalle, G, Zanalda, E, Lorettu, L, Clerici, M, Pagano, AM, Manzone, ML, Rivellini, G, Pessina, R, Pagano, A, Giordano, S, Santoriello, C, Rossetto, I, Babudieri, S, Celozzi, C, Lucania, L, Manzone, M, Nivoli, G, Quintavalle, G, Zanalda, E, Lorettu, L, Clerici, M, Pagano, AM, and Manzone, ML

Published
2019

18. Impact of a new carrageenan-based vaginal microbicide in a female population with genital HPV-infection: first experimental results.

Author

PERINO, A., CONSIGLIO, P., MARANTO, M., DE FRANCISCIS, P., MARCI, R., RESTIVO, V., MANZONE, M., CAPRA, G., CUCINELLA, G., and CALAGNA, G.

Abstract

OBJECTIVE: The objective of this study was to assess safety, satisfaction, and anti-viral effect of a new carrageenan-based vaginal microbicide in a population of fertile female patients with genital human papillomavirus (HPV) infection. PATIENTS AND METHODS: Forty healthy and sexually active women aged 18-45 years with genital HPV infection were enrolled. Each subject was treated with a gel formulated with 0.02% carrageenan and Propionibacterium extract (CGP) (Carvir, Depofarma SpA, Mogliano Veneto, Treviso, Italy). The subjects were evaluated at baseline, after the I cycle of therapy and after the II cycle. At final status, treatment acceptability and satisfaction were evaluated using a 5-point Likert scale. Furthermore, the rate of HPV genital infection clearance at final follow-up was evaluated. These data were compared with the HPV genital infection clearance rate in a control group of patients not subjected to any therapy. RESULTS: Overall, 68 HPV infections were detected at baseline, among 40 subjects enrolled. The HPV 16 genotype was the most frequent (12%) followed by HPV 18 (10%), and HPV 53 (9%). At the end of the study, 22 (55%) patients were very satisfied, 14 (35%) were satisfied, 3 (7.5%) were uncertain, and only 1 (2.5%) was dissatisfied, with 0 very dissatisfied. Only 2 patients complained of a local adverse event. Analysing infection clearance at the end of the study, 60% of patients became HPV negative. Among these, 13 cases were high-risk HPV infection. There were 16 patients with persistent infection ("non-responders"). No patient developed a "de novo" genital lesion. After controlling for age, the intervention had an adjusted OR of 4.9 (95% CI 1.6-15.1) to clear HPV. CONCLUSIONS: The results of this work suggest that Carvir vulvovaginal microbicide gel is safe and well-tolerated. Furthermore, this experience supports the hypothesis that CG has a role in accelerating the normal clearance of genital HPV infection in women with a positive HPV-DNA test. [ABSTRACT FROM AUTHOR]

Published
2019

19. ‘Podolian’ cattle: quanti-qualitative production of the milk in cows machine milked

Author

MATASSINO D., MANZONE M., OCCIDENTE M., SICILIANO B., ZULLO, ANTONIO, BARONE, CARMELA MARIA ASSUNTA, Matassino, D., Manzone, M., Occidente, M., Siciliano, B., Zullo, Antonio, and Barone, CARMELA MARIA ASSUNTA

Subjects
milk yield, machine milked, ‘Podolian’ cattle
Abstract

The purpose of the work was to detect the milk yield and milk composition in Autochthonous Italian Grey Cattle (ex Podolian) machine milked. The ‘Podolian’ breed derived from Bos primigenius primigenius (Aurochs) of the Near East with possible introgression from indigenous Aurochsen of Middle Southern Italy. Milk production was detected in a population of 97 cows of 'Masseria Colombo' farm. The milking technique adopted contemplates that, for around 8 months, after the machine milking of the morning, the calf remains with its mother for about 7-8 h. Therefore, the milk yield is referred to a single milking\day. The first recording data was carried out in May 2010 and the last one in January 2011. The attitude to machine milking was good. As expected, the individual milk yield, on average, increased with the parity order reaching in the third order: kg 213 ± 50 at 30 days, kg 421 ± 94 at 2 months, kg 609 ± 116 at 3 months and kg 1,215 ± 186 at 7 months (P

Published
2011

21. Long Term Repair and Maintenance Cost of some Professional Chainsaws

Author

Calvo A., Manzone M., and Spinelli R.

Subjects
biomass, harvesting, logging
Abstract

A sample of 44 professional chainsaws was used to determine service life and maintenance cost for this type of equipment. Data were sourced from a large workshop, catering for regional forest crews in north western Italy. Chainsaw service life exceeded 3000 hours, and spread over a period of 6 to 9 years. Under these conditions, maintenance cost averaged 820 (sic), or about 120 % of the investment cost. Annual usage was highest and maintenance cost lowest for mid-size chainsaws, in the 2 to 3.5 kW power class. Models at the two extreme ends (i.e. 3.5 kW) configured as specialist tools, which resulted in a lower usage and a higher maintenance cost per hour. The largest number of interventions (45% of the total) concerned the engine and the carburettor. The average chainsaw in the sample underwent 31 maintenance interventions over its service life. The cost per intervention varied between 7 and 50 (sic). Intervention cost was highest for engine work, and the lowest for overhaul. Overall, parts accounted for two-thirds of the cost, and labour for the remaining third. This study offers information about chainsaw service life and maintenance cost, obtained with scientific methods and hence suitable for general use.

Published
2013

38. Letters

Author

Manzone, M. G., Peirce, W. H., Smith, E. A. C., and Queneau, Paul E.

Published
1981
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41. Performance analysis of a tractor - power harrow system under different working conditions

Author

Michele Mattetti, D. Ricauda Aimonino, Alessandro Biglia, Paolo Balsari, Lorenzo Comba, Marco Manzone, D. Sacco, Paolo Barge, L. Eloi Alcatrão, Cristina Tortia, Massimiliano Varani, Balsari P., Biglia A., Comba L., Sacco D., Eloi Alcatrao L., Varani M., Mattetti M., Barge P., Tortia C., Manzone M., Gay P., and Ricauda Aimonino D.

Subjects
Tractor, Linear mixed effect model, business.product_category, Tillage operations, Soil Science, 01 natural sciences, Automotive engineering, Torque, Mathematics, Tillage operations, Power Take-Off torque, Draught, Fuel consumption, Energy consumption, 010401 analytical chemistry, Draught, 04 agricultural and veterinary sciences, Energy consumption, 0104 chemical sciences, Power (physics), Tillage, Harrow, Fuel consumption, Control and Systems Engineering, 040103 agronomy & agriculture, Fuel efficiency, 0401 agriculture, forestry, and fisheries, Power Take-Off torque, business, Agronomy and Crop Science, Food Science
Abstract

Tillage is one of the most important operations in the preparation of land for growing crops. Among secondary tillage implements, power harrows, which have a series of PTO-driven rotors which rotate about their vertical axis, are widely adopted in soil-working operations. Typically, this kind of implement is highly energy consuming, due to the heavy mechanical loads required to pull the harrow and the PTO (Power Take-Off) torque needed to drive the rotors. This paper reports the results of extensive in-field experimentation in which the relationship between the operating conditions of a tractor - power harrow system and the mechanical loads (i.e. PTO torque and draught) were investigated in two different test site fields. The test parameters consisted of: nominal tractor speed (3, 6, 9 and 12 km h−1), nominal working depth (6, 9 and 15 cm) and rotor speed (285 and 411 rpm) at a PTO speed of 1000 rpm. The data was statistically analysed by means of a linear mixed effect model to assess the differences in the tractor - harrow system performances measured under different working conditions. The presented results show which operating conditions can be favourable regarding energy and fuel consumption as this information may be very useful to farmers to reduce costs. Moreover, the measured mechanical loads concerning PTO torque and draught may also be beneficial for manufacturers to improve the design of these kinds of implements.

Published
2021

42. Tractor-rotary harrow forces interactions: first field measurements

Author

D. Ricauda Aimonino, P. Barge, A. Biglia, L. Comba, P. Gay, M. Manzone, M. Mattetti, G. Molari, C. Tortia, M. Varani, P. Balsari, and D. Ricauda Aimonino, P.Barge, A. Biglia, L. Comba, P. Gay, M. Manzone, M. Mattetti, G. Molari, C. Tortia, M. Varani, P. Balsari

Subjects
rotary harrow, efficiency. tractor
Published
2019

43. Robotic versus laparoscopic sacrocolpopexy for apical prolapse: a case-control study

Author

M Manzone, Giulia Accardi, Gloria Calagna, S Saitta, Antonino Perino, Giorgio Adile, G. Di Buono, Giorgio Romano, Gaspare Cucinella, Giorgio Gugliotta, Antonino Agrusa, Cucinella, G., Calagna, G., Romano, G., Di Buono, G., Gugliotta, G., Saitta, S., Adile, G., Manzone, M., Accardi, G., Perino, A., and Agrusa, A

Subjects
Sacrum, medicine.medical_specialty, 03 medical and health sciences, Gynecologic Surgical Procedures, 0302 clinical medicine, Robotic Surgical Procedures, Uterine Prolapse, medicine, Humans, Laparoscopic sacrocolpopexy, Robotic surgery, Robotic surgery - Sacrocolpopexy - Robotic sacrocolpopexy - Laparoscopic surgery - Apical prolapse, Laparoscopy, Aged, Pelvic floor, medicine.diagnostic_test, business.industry, Standard treatment, Case-control study, Middle Aged, Settore MED/40 - Ginecologia E Ostetricia, Surgery, Settore MED/18 - Chirurgia Generale, medicine.anatomical_structure, Apical prolapse, Case-Control Studies, 030220 oncology & carcinogenesis, Vagina, Feasibility Studies, Original Article, Female, 030211 gastroenterology & hepatology, business
Abstract

The apical prolapse has always been considered the most complex of the defects of the pelvic floor, for both the difficulty of the surgical corrective technique and for the high post-surgical recurrence rate. Today, the laparoscopic sacrocolpopexy can be considered the standard treatment for apical prolapse. In the last years, several author performed robotic sacrocolpopexy, obtaining positive results. So, we developed a case-control study in order to compare the surgical outcome of robotic group with a control group of laparoscopic approach in patients with symptomatic apical pro-lapsed between January 2015 and December 2015 at University Hospital Policlinico “P. Giaccone” and Ospedali Riuniti “Villa Sofia-Cervello”, Palermo. Our experience shows that robotic sacrocolpopexy can be considered in positive way for clinical results obtained: all procedures were executed with no complications, we noted a lower intraoperative blood loss and a shorter hospital stay than in laparoscopic group. Although the mean operative time and the economic costs are higher in robotic surgery, this study demonstrates that the use of robotic platform for repairing of symptomatic apical vaginal prolapse is feasible, safe and associated with short-term satisfactory results, representing therefore a valid alternative to laparoscopic approach.

Published
2016

44. Spontaneous bilateral tubal pregnancy in a nulliparous woman. Laparoscopic diagnosis and treatment

Author

Calagna, Gloria, Rossi, C., ADILE, Giorgio, MANZONE, Maria, PERINO, Antonino, CUCINELLA, Gaspare, Calagna, G., Rossi, C., Adile, G., Manzone, M., Perino, A., and Cucinella, G.

Subjects
Ectopic pregnancy, Obstetrics and Gynecology, Laparoscopy, Bilateral tubal pregnancy, Salpingostomy, Settore MED/40 - Ginecologia E Ostetricia
Abstract

A 34 year-old nulliparous woman was referred to our Department, complaining of vaginal bleeding and intermittent lower abdominal cramping. serum level of β-hCG was 4954 IU/L. Transvaginal ultrasound examination revealed no gestational sac in the uterine cavity and a right adnexal mass, suggestive of ectopic pregnancy; left adnexal area appeared regular. At laparoscopy, the presence of an ectopic pregnancy was confirmed in the right tube; on the left side, surprisingly, there was an intact infundibular ectopic pregnancy. Right tuba was removed; considering the condition of nulliparous of the patient, we decided to perform a linear salpingostomy. Histologic exam confirmed the diagnosis of spontaneous bilateral tubal ectopic pregnancies.

Published
2015

45. A multi-element psychosocial intervention for early psychosis (GET UP PIANO TRIAL) conducted in a catchment area of 10 million inhabitants: study protocol for a pragmatic cluster randomized controlled trial

Author

Ruggeri, Mirella, Bonetto, Chiara, Lasalvia, Antonio, Girolamo, De, G, Fioritti, A, Rucci, P, Santonastaso, P, Neri, G, Pileggi, F, Ghigi, D, Miceli, M, Scarone, S, Cocchi, A, Torresani, S, Faravelli, C, Zimmermann, Christa, Meneghelli, A, Cremonese, C, Scocco, P, Leuci, E, Mazzi, F, Gennarelli, M, Brambilla, P, Bissoli, S, Bertani, Me, Tosato, Sarah, DE SANTI, Katia, Poli, Sara, Cristofalo, Doriana, Tansella, Michele, Get, Up, Group, Ruggeri, M, Mirella, Me, Bonetto, C, Cristofalo, D, De Santi, K, Lasalvia, A, Lunardi, S, Negretto, V, Poli, S, Tosato, S, Zamboni, Mg, Ballarin, M, Bocchio, Chiavetto, L, Scasselatti, C, Zanardini, R, Bellani, Marcella, Bertoldo, A, Marinelli, Veronica, Perlini, Cinzia, Rambaldelli, Gianluca, Bertani, M, Lazzarotto, L, Bardella, S, Gardellin, F, Lamonaca, D, Lunardon, M, Magnabosco, R, Martucci, M, Nicolau, S, Nifosì, F, Pavanati, M, Rossi, M, Piazza, C, Piccione, G, Sala, A, Sale, A, Stefan, B, Zotos, S, Balbo, M, Boggian, I, Ceccato, E, Dall'Agnola, R, Girotto, B, Goss, Claudia, Leoni, R, Mai, A, Pasqualini, A, Roccato, S, Rossi, A, Strizzolo, S, Urbani, A, Ald, F, Bianchi, B, Cappellari, P, Conti, R, Battisti, De, Lazzarin, E, Merlin, S, Migliorini, G, Pozzan, T, Sarto, L, Visonà, S, Brazzoli, A, Campi, A, Carmagnani, R, Giambelli, S, Gianella, A, Lunardi, L, Madaghiele, D, Maestrelli, P, Paiola, L, Posteri, E, Viola, L, Zamberlan, V, Zenari, M, Zanoni, M, Bonadonna, G, Bonomo, M, Veronese, A, Anderle, P, Angelozz, A, Amalric, I, Baron, G, Candeago, Eb, Castelli, F, Chieco, M, Costanzo, Di, E, Derossi, M, Doriguzzi, M, Galvano, O, Lattanz, M, Lezzi, R, Marcato, M, Marcolin, A, Marini, F, Matranga, M, Scalabrin, D, Zucchetto, M, Zadro, F, Austoni, G, Bianco, M, Bordino, F, Dario, F, Risio, De, A, Gatto, A, Granà, S, Favero, E, Franceschin, A, Friederici, S, Marangon, V, Pascolo, M, Ramon, L, Zambolin, S, Riolo, R, Buffon, A, Bortolo, Di, Fortin, S, Matarrese, F, Mogni, S, Codemo, N, Russi, A, Silvestro, A, Turella, E, Viel, P, Dominoni, A, Andreose, L, Boemio, M, Bressan, L, Cabbia, A, Canesso, E, Cian, R, Dal, Piccol, Dalla, C, Pasqua, Mm, Prisco, Di, Mantellato, L, Luison, M, Morgante, S, Santi, M, Sacillotto, M, Scabbio, M, Sponga, P, Sguotto, Ml, Stach, F, Vettorato, Mg, Martinello, G, Dassiè, F, Marino, S, Cibiniel, L, Masetto, I, Cabianca, O, Valente, A, Caberlotto, L, Passoni, A, Flumian, P, Daniel, L, Gion, M, Stanziale, S, Alborino, F, Bortolozzo, V, Bacelle, L, Bicciato, L, Basso, D, Navaglia, F, Manoni, F, Ercolin, M, Giubilini, F, Imbesi, M, Semrov, E, Giovanni, Cs, Taro, E, Ceno, V, Ovest, P, Anelli, S, Amore, M, Bigi, L, Britta, W, Anna, Gb, Bonatti, U, Borziani, M, Crosato, I, Galluccio, R, Galeotti, M, Gozzi, M, Greco, V, Guagnini, E, Pagani, S, Maccherozzi, M, Marchi, F, Melato, E, Mazzucchi, E, Marzullo, F, Pellegrini, P, Petrolini, N, Volta, P, Bonara, F, Brusamonti, E, Croci, R, Flamia, I, Fontana, F, Losi, R, Marchioro, R, Raffaini, L, Ruju, L, Saginario, A, Tondelli, Mg, Marrama, D, Bernardelli, L, Bonacini, F, Florindo, A, Merli, M, Nappo, P, Sola, L, Tondelli, O, Tonna, M, Torre, Mt, Tosatti, M, Venturelli, G, Zampolla, D, Bernardi, A, Cavalli, C, Cigala, L, Ciraudo, C, Bari, Di, Ferri, L, Gombi, F, Leurini, S, Mandatelli, E, Maccaferri, S, Oroboncoide, M, Pisa, B, Ricci, C, Poggi, E, Zurlini, C, Malpeli, M, Colla, R, Teodori, E, Vecchia, L, D'Andrea, R, Trenti, T, Paolini, P, Carpeggiani, P, Gagliostro, M, Pratelli, M, Lazzaro, S, Antonelli, A, Battistini, L, Bellini, F, Bonini, E, Capelli, Cb, Didomizio, C, Drei, C, Fucci, G, Gualandi, A, Grazia, Mr, Losi, Am, Mazzoni, Fm, Marangoni, D, Monna, G, Morselli, M, Oggioni, A, Oprandi, S, Paganelli, W, Passerini, M, Piscitelli, M, Reggiani, G, Rossi, G, Salvatori, F, Trasforini, S, Uslenghi, C, Veggetti, S, Bartolucci, G, Baruffa, R, Bertelli, R, Borghi, L, Ciavarella, P, Paltrinieri, E, Rizzardi, F, Serra, P, Suzzi, D, Carlo, U, Arienti, P, Aureli, F, Avanzi, R, Callegari, V, Corsino, A, Host, P, Michetti, R, Rizzo, F, Simoncelli, P, Soldati, E, Succi, E, Bertozzi, M, Canetti, E, Cavicchioli, L, Ceccarelli, E, Cenni, S, Marzola, G, Gallina, V, Leoni, C, Olivieri, A, Piccolo, E, Ravagli, S, Russo, R, Tedeschini, D, Verenini, M, Abram, W, Granata, V, Curcio, A, Guerra, G, Granini, S, Natali, L, Montanari, E, Pasi, F, Ventura, U, Valenti, S, Francesca, M, Farneti, R, Ravagli, P, Floris, R, Maroncelli, O, Volpones, G, Casali, D, Bencini, A, Cellini, M, Biase, De, Barbara, L, Charles, L, Pratesi, C, Tanini, A, Loparrino, R, Ulivelli, C, Cussoto, C, Dei, N, Fumanti, E, Pantani, M, Zeloni, G, Bellini, R, Cellesi, R, Dorigo, N, Gullì, P, Ialeggio, L, Pisanu, M, Rinaldi, G, Konze, A, Modignani, L, Frova, M, Monzani, E, Zanobio, A, Malagoli, M, Pagani, R, Barbera, S, Morganti, C, Amadè, Es, Brambilla, V, Montanari, A, Caterina, G, Lopez, C, Marocchi, A, Moletta, A, Sberna, M, Cascio, Mt, Manzone, Ml, Barbara, B, Mari, L, Razzini, E, Bianchi, Y, Pellizzer, Mr, Verdecchia, A, Sferrazza, Mg, Pismataro, R, D'Eril, Gv, Barassi, A, Pacciolla, R, Faraci, G, Rosmini, B, Carpi, F, Soelva, M, Anderlan, M, Francesco, De, M, Duregger, E, Vettori, C, Doimo, S, Kompatscher, E, Forer, M, Kerschbaumer, H, Gampe, A, Nicoletti, M, Acerbi, C, Aquilino, D, Azzali, S, Bensi, L, Cappellari, D, Casana, E, Campagnola, N, Dal, Corso, Di, E, Micco, E, Gobbi, E, Mairaghi, L, Malak, S, Mesiano, L, Paterlini, F, Perini, M, Puliti, Em, Rispoli, R, Rizzo, E, Sergenti, C, Soave, M, Alpi, A, Bislenghi, L, Bolis, T, Colnaghi, F, Fascendini, S, Grignani, S, Patelli, G, Casale, S, Zimmermann, C, Deledda, G, Goss, C, Mazzi, Maria Angela, Rimondini, Michela, Scassellati, C, Bonvicini, C, Longo, S, Ventriglia, M, Squitti, R, Frisoni, G, Pievani, M, Balestrieri, M, Perlini, C, Marinelli, V, Bellani, M, Rambaldelli, G, Atzori, M, Beltramello, A, Alessandrini, F, Pizzini, Francesca, Zoccatelli, G, Politi, P, Emanuele, E, Brondino, N, Martino, G, Bergami, A, Zarbo, R, Riva, Ma, Fumagalli, F, Molteni, R, Calabrese, F, Guidotti, G, Luoni, A, Macchi, F, Artioli, S, Baldetti, M, Bizzocchi, M, Bolzon, D, Bonello, E, Cacciari, G, Carraresi, C, Caselli, G, Furlato, K, Garlassi, S, Gavarini, A, Macchetti, F, Marteddu, V, Plebiscita, G, Totaro, S, Bebbington, P, Birchwood, M, Dazzan, P, Kuipers, E, Thornicroft, G, Pariante, C, Lawrie, S, Soares, J. C., Ruggeri, M., Bonetto, C., Lasalvia, A., De Girolamo, G., Bertani, M., Rucci, P., Santonastaso, P., Neri, G., Pileggi, F., Ghigi, D., Miceli, M., Scarone, S., Cocchi, A., Torresani, S., Faravelli, C., Zimmermann, C., Meneghelli, A., Cremonese, C., Scocco, P., Leuci, E., Mazzi, F., Gennarelli, Massimo, Brambilla, P., Bissoli, S., Lazzarotto, L., Bardella, S., Gardellin, F., Lamonaca, D., Lunardon, M., Magnabosco, R., Martucci, M., Nicolau, S., Nifosì, F., Bertani, M. E., Tosato, S., De Santi, K., Poli, S., Cristofalo, D., Tansella, Michele, Lunardi, S., Negretto, V., Zamboni, M. G., Ballarin, M., Chiavetto, Luisella Bocchio, Scasselatti, C., Zanardini, R., Bellani, M., Bertoldo, A., Marinelli, Valentina, Perlini, C., Rambaldelli, G., Pasqualini, A., Pavanati, M., Rossi, M., Piazza, C., Piccione, G., Sala, A., Roccato, S., Rossi-, A., Sale, A., Stefan, B., Strizzolo, S., Zotos, S., Balbo, M., Boggian, I., Ceccato, E., Dall’Agnola, R., Girotto, B., Leoni, R., Mai, A., Urbani, Alessandro, Ald, F., Bianchi, Benedetta, Cappellari, P., Conti, R., De Battisti, L., Lazzarin, E., Merlin, S., Migliorini, G., Pozzan, T., Sarto, L., Visonà, S., Brazzoli, A., Campi, A., Carmagnani, R., Giambelli, S., Gianella, A., Lunardi-, L., Madaghiele, D., Maestrelli, P., Paiola, L., Posteri, E., Viola, L., Zamberlan, V., Zenari, M., Zanoni, M., Bonadonna, G., Bonomo, M., Veronese, A., Anderle, P., Angelozz, A., Amalric, I., Baron, G., Candeago, E. B., Castelli, F., Chieco, M., Di Costanzo, E., Derossi, M., Doriguzzi, M., Galvano, O., Lattanz, M., Lezzi, R., Marcato, M., Marcolin, A., Marini, F., Matranga, M., Scalabrin, D., Zucchetto, M., Zadro, F., Austoni, G., Bianco, M., Bordino, F., Dario, F., DE RISIO, Alfredo, Gatto, A., Granà, S., Favero, E., Franceschin, A., Friederici, S., Marangon, V., Pascolo, M., Ramon, L., Zambolin, S., Riolo, R., Buffon, A., Di Bortolo, E., Fortin, S., Matarrese, F., Mogni, S., Codemo, N., Russi, A., Silvestro, Antonina, Turella, E., Viel, P., Dominoni, A., Andreose, L., Boemio, M., Bressan, L., Cabbia, A., Canesso, E., Cian, R., Dal Piccol, C., Dalla Pasqua, M. M., Di Prisco, A., Mantellato, L., Luison, M., Morgante, S., Santi, M., Sacillotto, M., Scabbio, M., Sponga, P., Sguotto, M. L., Stach, F., Vettorato, M. G., Martinello, G., Dassiè, F., DI MARINO, Simone, Cibiniel, L., Masetto, I., Cabianca, O., Valente, MADDALENA AGNESE, Caberlotto, L., Passoni, A., Flumian, P., Daniel, L., Gion, M., Stanziale, S., Alborino, F., Bortolozzo, V., Bacelle, L., Bicciato, L., Basso, D., Navaglia, F., Manoni, F., Ercolin, M., Giubilini, F., Imbesi, M., Semrov, E., Giovanni, C. S., Taro e Ceno, V., Ovest, P., Anelli, S., Amore, M., Bigi, L., Britta, W., Anna, G. B., Bonatti, U., Borziani, M., Crosato, I., Galluccio, R., Galeotti, M., Gozzi, M., Greco, V., Guagnini, E., Pagani, S., Maccherozzi, M., Marchi, F., Melato, E., Mazzucchi, E., Marzullo, F., Pellegrini, Pietro Carlo, Petrolini, N., Volta, P., Bonara, F., Brusamonti, E., Croci, R., Flamia, I., Fontana, F., Losi, R., Marchioro, R., Raffaini, L., Ruju, L., Saginario, A., Tondelli, M. G., Marrama, D., Bernardelli, L., Bonacini, F., Florindo, A., Merli, M., Nappo, P., Sola, L., Tondelli-, O., Tonna, M., Torre, M. T., Tosatti, M., Venturelli, G., Zampolla, D., Bernardi, A., Cavalli, Chiara, Cigala, L., Ciraudo, C., Di Bari, A., Ferri, L., Gombi, F., Leurini, S., Mandatelli, E., Maccaferri, S., Oroboncoide, M., Pisa, B., Ricci, Carmine, Poggi, E., Zurlini, C., Malpeli, M., Colla, R., Teodori, E., Vecchia, L., D’Andrea, R., Trenti, T., Paolini, P., Carpeggiani, P., Gagliostro, M., Pratelli, M., Lazzaro, S., Antonelli, A., Battistini, Luca, Bellini, Fiorella, Bonini, E., Capelli, C. B., Didomizio, C., Drei, C., Fucci, G., Gualandi, A., Grazia, M. R., Losi-, A. M., Mazzoni, F. M., Marangoni, D., Monna, G., Morselli, M., Oggioni, A., Oprandi, S., Paganelli, W., Passerini, M., Piscitelli, M., Reggiani, G., Rossi-, G., Salvatori, Franco, Trasforini, S., Uslenghi, C., Veggetti, S., Bartolucci, Giuliana, Baruffa, R., Bertelli, R., Borghi, L., Ciavarella, P., Paltrinieri, E., Rizzardi, F., Serra, P., Suzzi, D., Carlo, U., Arienti, P., Aureli, F., Avanzi, R., Callegari, V., Corsino, A., Host, P., Michetti, R., Rizzo, F., Simoncelli, P., Soldati, E., Succi, E., Bertozzi, M., Canetti, E., Cavicchioli, L., Ceccarelli, E., Cenni, S., Marzola, G., Gallina, V., Leoni, C., Olivieri, A., Piccolo, Elisa, Ravagli, S., Russo, R., Tedeschini, D., Verenini, M., Abram, W., Granata, V., Curcio, A., Guerra, G., Granini, S., Natali, L., Montanari, Eleonora, Pasi, F., Ventura, U., Valenti, S., Francesca, M., Farneti, R., Ravagli-, P., Floris, R., Maroncelli, O., Volpones, G., Casali, D., Bencini, A., Cellini, M., De Biase, L., Barbara, L., Charles, L., Pratesi, C., Tanini, A., Loparrino, R., Ulivelli, C., Cussoto, C., Dei, N., Fumanti, E., Pantani, M., Zeloni, G., Bellini-, R., Cellesi, R., Dorigo, N., Gullì, P., Ialeggio, L., Pisanu, M., Rinaldi, G., Konze, A., Modignani, L., Frova, M., Monzani, E., Amadè, E. S., Zanobio, A., Malagoli, M., Pagani-, R., Barbera, S., Morganti, C., Brambilla-, V., Montanari-, A., Caterina, G., LOPEZ CORTES, Carlo, Marocchi, A., Moletta, A., Sberna, M., Cascio, M. T., Manzone, M. L., Barbara-, B., Mari, L., Razzini, E., Bianchi-, Y., Pellizzer, M. R., Verdecchia, A., Sferrazza, M. G., Pismataro, R., D’Eril, G. V., Barassi, A., Pacciolla, R., Faraci, G., Rosmini, B., Carpi, F., Soelva, M., Anderlan, M., De Francesco, M., Duregger, E., Vettori, C., Doimo, S., Kompatscher, E., Forer, M., Kerschbaumer, H., Gampe, A., Nicoletti, M., Acerbi, C., Aquilino, D., Azzali, S., Bensi, L., Cappellari-, D., Casana, E., Campagnola, N., Dal Corso, E., Di Micco, E., Gobbi, E., Mairaghi, L., Malak, S., Mesiano, L., Paterlini, F., Perini, Matteo, Puliti, E. M., Rispoli, R., Rizzo-, E., Sergenti, C., Soave, M., Alpi, A., Bislenghi, L., Bolis, T., Colnaghi, F., Fascendini, S., Grignani, S., Patelli, G., Casale, S., Deledda, G., Goss, C., Mazzi-, M., Rimondini, M., Scassellati, C., Bonvicini, C., Longo, Salvatore, Bocchio Chiavetto, L., Ventriglia, M., Squitti, R., Frisoni, G., Pievani, M., Balestrieri, M., Atzori, M., Beltramello, A., Alessandrini, F., Pizzini, F., Zoccatelli, G., Politi, P., Emanuele, E., Brondino, N., Martino, G., Bergami, A., Zarbo, R., Riva, M. A., Fumagalli, F., Molteni, R., Calabrese, F., Guidotti, Giovanni, Luoni, Alessia, Macchi, F., Artioli, S., Baldetti, M., Bizzocchi, M., Bolzon, D., Bonello, E., Cacciari, G., Carraresi, C., Caselli, G., Furlato, K., Garlassi, S., Gavarini, A., Macchetti, F., Marteddu, V., Plebiscita, G., Totaro, S., Bebbington, P., Birchwood, M., Dazzan, P., Kuipers, E., Thornicroft, G., Pariante, C., Lawrie, S., Soares, J. C., Mirella Ruggeri, Chiara Bonetto, Antonio Lasalvia, Giovanni De Girolamo, Angelo Fioritti, Paola Rucci, Paolo Santonastaso, Giovanni Neri, Francesca Pileggi, Daniela Ghigi, Maurizio Miceli, Silvio Scarone, Angelo Cocchi, Stefano Torresani, Carlo Faravelli, Christa Zimmermann, Anna Meneghelli, Carla Cremonese, Paolo Scocco, Emanuela Leuci, Fausto Mazzi, Massimo Gennarelli, Paolo Brambilla, Sarah Bissoli, Maria Elena Bertani, Sarah Tosato, Katia De Santi, Sara Poli, Doriana Cristofalo, Michele Tansella, and and THE GET UP GROUP

Subjects
Research design, Time Factors, early psychosis, psychosocial interventions, cluster randomized triales, medicine.medical_treatment, Psychological intervention, Medicine (miscellaneous), Assertive community treatment, Severity of Illness Index, law.invention, Study Protocol, Randomized controlled trial, law, Recurrence, Early psychosi, Cluster Analysis, Pharmacology (medical), lcsh:R5-920, Family Relation, Community Mental Health Service, First-episode psychosis, Community Mental Health Center, Community Mental Health Services, Cognitive behavioral therapy, Treatment Outcome, Cognitive Therapy, Italy, Research Design, First-episode psychosisEarly psychosisCognitive behavioral therapyPsychosocial interventionAssertive community treatment, Family Relations, lcsh:Medicine (General), Psychosocial, Human, pragmatic trial, Early psychosis, Family intervention, Psychosocial intervention, Community Mental Health Centers, Humans, Patient Selection, Psychotic Disorders, Sample Size, Case Management, Cognitive Behavioral Therapy, medicine.medical_specialty, psychosocial interventions, Time Factor, cluster randomized triales, Psychotic Disorder, First-episode psychosi, medicine, Psychiatry, Cluster Analysi, business.industry, Mental health, Cognitive therapy, business
Abstract

Background Multi-element interventions for first-episode psychosis (FEP) are promising, but have mostly been conducted in non-epidemiologically representative samples, thereby raising the risk of underestimating the complexities involved in treating FEP in ‘real-world’ services. Methods/Design The Psychosis early Intervention and Assessment of Needs and Outcome (PIANO) trial is part of a larger research program (Genetics, Endophenotypes and Treatment: Understanding early Psychosis - GET UP) which aims to compare, at 9 months, the effectiveness of a multi-component psychosocial intervention versus treatment as usual (TAU) in a large epidemiologically based cohort of patients with FEP and their family members recruited from all public community mental health centers (CMHCs) located in two entire regions of Italy (Veneto and Emilia Romagna), and in the cities of Florence, Milan and Bolzano. The GET UP PIANO trial has a pragmatic cluster randomized controlled design. The randomized units (clusters) are the CMHCs, and the units of observation are the centers’ patients and their family members. Patients in the experimental group will receive TAU plus: 1) cognitive behavioral therapy sessions, 2) psycho-educational sessions for family members, and 3) case management. Patient enrolment will take place over a 1-year period. Several psychopathological, psychological, functioning, and service use variables will be assessed at baseline and follow-up. The primary outcomes are: 1) change from baseline to follow-up in positive and negative symptoms’ severity and subjective appraisal; 2) relapse occurrences between baseline and follow-up, that is, episodes resulting in admission and/or any case-note records of re-emergence of positive psychotic symptoms. The expected number of recruited patients is about 400, and that of relatives about 300. Owing to the implementation of the intervention at the CMHC level, the blinding of patients, clinicians, and raters is not possible, but every effort will be made to preserve the independency of the raters. We expect that this study will generate evidence on the best treatments for FEP, and will identify barriers that may hinder its feasibility in ‘real-world’ clinical settings, patient/family conditions that may render this intervention ineffective or inappropriate, and clinical, psychological, environmental, and service organization predictors of treatment effectiveness, compliance, and service satisfaction. Trial registration ClinicalTrials.gov Identifier NCT01436331

Published
2012

46. "A Space Odyssey" on Laparoscopic Segmental Rectosigmoid Resection for Deep Endometriosis: A Seventeen-year Retrospective Analysis of Outcomes and Postoperative Complications among 3050 Patients Treated in a Referral Center.

Author

Ceccaroni M, Ceccarello M, Raimondo I, Roviglione G, Clarizia R, Bruni F, Mautone D, Manzone M, Facci E, Rettore L, Rossini R, Bertocchi E, Barugola G, Ruffo G, and Barra F

Subjects
Female, Humans, Retrospective Studies, Anastomotic Leak surgery, Rectovaginal Fistula surgery, Treatment Outcome, Postoperative Complications epidemiology, Postoperative Complications etiology, Postoperative Complications surgery, Referral and Consultation, Endometriosis complications, Rectal Diseases epidemiology, Laparoscopy adverse effects, Laparoscopy methods
Abstract

Study Objective: To evaluate the feasibility of laparoscopic rectosigmoid resection for bowel endometriosis (RSE), reporting surgical and short-term postoperative outcomes in a consecutive large series of patients., Design: A retrospective cohort study., Setting: Third-level national referral center for deep endometriosis (DE)., Patients: 3050 patients with symptomatic RSE requiring surgical treatment., Interventions: Nerve-sparing laparoscopic resection for RSE perfomed by a multidisciplinary team. After collecting intraoperative surgical characteristics, postoperative complications were collected by evaluating the risk factors associated with their onset., Measurements and Main Results: Clavien-Dindo IIIb postoperative complications were noted in 13.1% of patients, with anastomotic leakage and rectovaginal fistula accounting for 3.0% and 1.9%, respectively. Postoperative bladder impairment was observed in 13.9% of patients during hospital discharge but spontaneously decreased to 4.5% at the first evaluation after 30 days, alongside a statistically significant change towards global symptom improvement. Multivariate analyses were done to identify the risk factors for segmental bowel resection in terms of occurrence of postoperative major complications. Ultralow (≤5 cm from the anal verge), low rectal anastomosis (<8 cm, >5 cm), parametrectomy, vaginal resection, and previous surgeries seemed more related to anastomotic leakage, rectovaginal fistula, and bladder retention., Conclusions: Laparoscopic rectosigmoid resection for RSE seems an effective and feasible procedure. The surgical complication rate is not negligible but could be reduced by implementing a multidisciplinary approach, an endless improvement in nerve-sparing techniques and surgical anatomy, as well as technological enhancements. Real future challenges will be to reduce the time for the first diagnosis of DE and the likelihood of surgical indications., (Copyright © 2023 AAGL. Published by Elsevier Inc. All rights reserved.)

Published
2023
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47. Heat can treat: long-term follow-up results after uterine-sparing treatment of adenomyosis with radiofrequency thermal ablation in 60 hysterectomy candidate patients.

Author

Stepniewska AK, Baggio S, Clarizia R, Bruni F, Roviglione G, Ceccarello M, Manzone M, Guerriero M, and Ceccaroni M

Subjects
Dysmenorrhea complications, Dysmenorrhea surgery, Female, Follow-Up Studies, Hot Temperature, Humans, Hysterectomy, Pelvic Pain etiology, Pelvic Pain surgery, Retrospective Studies, Uterine Hemorrhage, Adenomyosis complications, Adenomyosis surgery, Endometriosis complications, Endometriosis surgery
Abstract

Background: Adenomyosis may induce pelvic pain, abnormal uterine bleeding or bulk symptoms. If hormonal treatment proves ineffective or contraindicated, hysterectomy may be necessary. For patients who desire to conserve the uterus despite severe symptomatology, uterine-sparing techniques have been introduced. Radiofrequency thermal ablation (RFA) consists of the local application of high temperature to eliminate diseased tissue, applied recently for adenomyosis treatment. The objective of the study was to analyze the efficacy of RFA for avoiding hysterectomy in patients with adenomyosis-related symptoms., Methods: This is a single-center, retrospective cohort study performed in a referral center for endometriosis. The study population consisted of all consecutive patients who underwent Radiofrequency thermal ablation (RFA) treatment as an alternative to hysterectomy for adenomyosis between March 2011 and June 2019 in our institution. RFA was performed using laparoscopic access. To evaluate the impact of RFA treatment on symptoms, follow-up findings were compared to preoperative symptomatology using the ten-point visual analog scale (VAS) for pain assessment., Results: Sixty patients were included in the study, 39 of them (65%), underwent a concomitant surgery for endometriosis in association to RFA. On a long-term follow-up (mean 56 months (range 10-115, SD 29), hysterectomy was performed in 8 patients (13%). The mean VAS score before vs after surgery was 7.4 vs 3.3 for dysmenorrhea, 3.7 vs 0.3 for dyschezia, 4.7 vs 0.7 for dyspareunia, and 4.0 vs 1.4 for chronic pelvic pain, being significantly reduced after RFA for all these pain components (p < 0.0001 in every case). Thirty-one patients (52%) suffered from AUB before RFA, this symptom persisted in 10 patients (16%) during follow-up (p < 0.001). Bulk symptoms were present in 16 patients (27%) and disappeared after RFA in all cases., Conclusions: RFA allows for hysterectomy avoidance in most cases. It leads to marked improvements in pain symptomatology, uterine bleeding and bulk symptoms., (© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)

Published
2022
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48. Dienogest vs GnRH agonists as postoperative therapy after laparoscopic eradication of deep infiltrating endometriosis with bowel and parametrial surgery: a randomized controlled trial.

Author

Ceccaroni M, Clarizia R, Liverani S, Donati A, Ceccarello M, Manzone M, Roviglione G, and Ferrero S

Subjects
Endometriosis pathology, Endometriosis physiopathology, Female, Humans, Intestines surgery, Leuprolide therapeutic use, Nandrolone therapeutic use, Pelvic Pain drug therapy, Peritoneum surgery, Pregnancy, Recurrence, Reoperation adverse effects, Secondary Prevention methods, Treatment Outcome, Triptorelin Pamoate therapeutic use, Endometriosis surgery, Gonadotropin-Releasing Hormone agonists, Laparoscopy methods, Nandrolone analogs & derivatives, Postoperative Care methods
Abstract

Background: The recurrence of deep infiltrating endometriosis (DIE) after its surgical excision is a big problem: postoperative treatment is crucial., Objective: To compare two postoperative treatments: Dienogest and GnRH agonists., Design: Prospective Randomized Controlled Trial (RCT)., Patients: 146 women submitted to laparoscopic eradication of DIE with bowel and parametrial surgery., Interventions: Patients were randomized into two groups. Group A ( n  = 81) received Triptorelin or Leuprorelin 3.75 mg every 4 weeks for 6 months. Group B ( n  = 65) received Dienogest 2 mg/day for at least 6 months. A first interview made after six months valued compliance to therapy, treatment tolerability, pain improvement, and side effects. A second interview at 30 ± 6 months valued pain relapse, imaging relapse, and pregnancy rate., Main Outcomes: The primary outcome was to demonstrate the non-inferiority of Dienogest about the reduction in pain recurrence. Secondary outcomes were differences in terms of treatment tolerability, side effects, imaging relapse rate, and pregnancy rate., Results: Both Dienogest and GnRH agonists were associated with a highly significant reduction of pain at 6 and 30 months, without any significant difference ( p  < .001). About treatment tolerability, a more satisfactory profile was reported with Dienogest ( p  = .026). No difference in terms of clinical relapse, imaging relapse, and live births was found., Conclusions: Dienogest has proven to be as effective as GnRH agonists in preventing recurrence of DIE and associated pelvic pain after surgery. Also, it is better tolerated by patients.

Published
2021
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50. Efficacy and acceptance of the sacral neuromodulation in the treatment of female lower urinary tract dysfunctions.

Author

Adile B, Speciale P, Gugliotta G, Consiglio P, Manzone M, Adile G, Saitta S, Perino A, and Calagna G

Subjects
Female, Humans, Middle Aged, Patient Acceptance of Health Care, Prospective Studies, Sacrum innervation, Treatment Outcome, Electric Stimulation Therapy methods, Urinary Bladder, Overactive therapy, Urinary Retention therapy
Published
2018
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