Search

Your search keyword '"MACH, Pawel"' showing total 176 results
Start Over Author "MACH, Pawel"
176 results on '"MACH, Pawel"'

1. First-Line Lenvatinib Plus Pembrolizumab Versus Chemotherapy for Advanced Endometrial Cancer: A Randomized, Open-Label, Phase III Trial

Author

Marth, Christian, Moore, Richard G., Bidziński, Mariusz, Pignata, Sandro, Ayhan, Ali, Rubio, M. Jesús, Beiner, Mario, Hall, Marcia, Vulsteke, Christof, Braicu, Elena Ioana, Sonoda, Kenzo, Wu, Xiaohua, Frentzas, Sophia, Mattar, André, Lheureux, Stephanie, Chen, Xiaojun, Hasegawa, Kosei, Magallanes-Maciel, Manuel, Choi, Chel Hun, Shalkova, Mariia, Kaen, Diego, Wang, Peng-Hui, Berger, Regina, Okpara, Chinyere E., McKenzie, Jodi, Yao, Lili, Orlowski, Robert, Khemka, Vivek, Gilbert, Lucy, Makker, Vicky, Kaen, Diego Lucas, Gomez Abuin, Gonzalo, Zamora, Liliana Beatriz, Alfie, Margarita Sonia, Casarini, Ignacio Alfredo, Harrison, Michelle, Ananda, Sumitra, Shannon, Catherine Margaret, Frentzas, Sophia, Friedlander, Michael, Meniawy, Tarek, Gao, Bo, Baron-Hay, Sally, Diakos, Connie, Marth, Christian, Polterauer, Stephan, Petru, Edgar, De Bock, Marlies, Vulsteke, Christof, Baurain, Jean-Francois, Van Gorp, Toon, Altintas, Sevilay, Lima, Joao Paulo da Silveira Nogueira, Mattar, Andre, de Freitas Junior, Ruffo, Santana, Rosane O., de Melo, Andreia Cristina, Franke, Fabio Andre, Zibetti Dal Molin, Graziela, Damian, Fernanda Bronzon, Guedes, João Daniel Cardoso, Ellard, Susan, Tinker, Anna, Samouëlian, Vanessa, Fortin, Suzanne, Bessette, Paul, Kolinsky, Michael, Kumar Tyagi, Nidhi, Ethier, Josee-Lyne, Gilbert, Lucy, Lheureux, Stephanie, MacKay, Helen, Lim, Charles, Wu, Xiaohua, Pan, Lingya, An, Ruifang, Chen, Xiaojun, Zheng, Hong, Wu, Yumei, Zhu, Jianqing, Yao, Shuzhong, Jia, Xuemei, Huang, Yi, Lv, Weiguo, Zhang, Yu, Zhou, Qi, Ma, Cailing, Chekerov, Radoslav, Mach, Pawel, Witteler, Ralf, Marmè, Frederik, Cadoo, Karen, Korach, Jacob, Levy, Talia, Beiner, Mario, Amnon, Amit, Scollo, Paolo, Naglieri, Emanuele, Pignata, Sandro, Zamagni, Claudio, Salutari, Vanda, Usami, Tomoka, Nakamura, Kazuto, Matsumoto, Koji, Yamagami, Wataru, Kobayashi, Yoichi, Takano, Masashi, Kato, Hidenori, Sonoda, Kenzo, Kikuchi, Akira, Katsumata, Noriyuki, Kamiura, Shoji, Horie, Koji, Hasegawa, Kosei, Tsunoda, Takuya, Suzuki, Nao, Yunokawa, Mayu, Nishio, Shin, Kudaka, Wataru, Guerrero Cabrera, Fernando Felix, Gonzalez Mendoza, Rene Lazaro, Magallanes Maciel, Manuel Ernesto, Villalobos Valencia, Ricardo, Escobar Penagos, Jose, Lopez Chuken, Yamil Alonso, Mackowiak-Matejczyk, Beata, Tarnawski, Rafal, Kalinka, Ewa, Bidzinski, Mariusz, Bednarek, Wieslawa, Danska-Bidzinska, Anna, Koralewski, Piotr, Roszak, Andrzej, Kedrova, Anna, Musaeva, Natalia, Urmancheeva, Adiliya Fettekhovna, Vasiliev, Aleksandr Gennadievich, Safina, Sufia Zievna, Lisyanskaya, Alla Sergeevna, Rykov, Ivan V., Rumyantsev, Alexey Alexandrovich, Belonogov, Aleksandr, Makarycheva, Yulia, Kim, Yong Man, Choi, Chel Hun, Kim, Yong Beom, Kim, Hee Seung, Kim, Sang Wun, Quindos Varela, Maria, Casado Herraez, Antonio, Diaz Redondo, Tamara, Rubio Perez, Maria Jesus, Romeo Marin, Margarita, Romero Noguera, Ignacio, Taus Garcia, Alvaro, Lin, Wu-Chou, Chou, Hung-Hsueh, Cheng, Wen-Fang, Lu, Chien-Hsing, Wang, Peng-Hui, Simsek, Tayup, Kose, Fatih, Ayhan, Ali, Vardar, Mehmet Ali, Ozerkan, Kemal, Hughes, Andrew, Stillie, Alison, Eminowicz, Gemma, Khalique, Saira, Shalkova, Mariia, Sukhina, Olena, Piatnytska, Tetiana, Averina, Hanna, Kulyaba, Yaroslav, Kryzhanivska, Anna, Bondarenko, Igor, Svintsitsky, Valentyn, Krasnohrud, Yuliia, Voitko, Nataliia, Buscema, Joseph, Ghamande, Sharad, Lewin, Sharyn, Graham, Deena M., Makker, Vicky, Bell, Maria, Santin, Alessandro, Lee, Christine, Blank, Stephanie, Konecny, Gottfried E., Corr, Bradley, Van Le, Linda, Moore, Richard G., Scalici, Jennifer, Anderson, Charles, Braly, Patricia, Fehniger, Julia, Westhoff, Gina, and Bollinger, Lauren

Published
2024
Full Text
View/download PDF

7. Alteration in sB7-H4 Serum Levels and Placental Biomarker Expression after Therapeutic Plasma Exchange in Early-Onset Preeclampsia Patients.

Author

Duan, Liyan, Ma, Yuyang, Reisch, Beatrix, Hadrovic, Elina, Mach, Pawel, Kimmig, Rainer, Jahn, Michael, Köninger, Angela, Iannaccone, Antonella, and Gellhaus, Alexandra

Subjects
DURATION of pregnancy, HIGH-risk pregnancy, PREGNANCY outcomes, PLASMA exchange (Therapeutics), PREGNANCY proteins, PREECLAMPSIA
Abstract

Therapeutic plasma exchange (TPE) is a widely used treatment for numerous diseases including pregnancy-related conditions. Our prior study on 20 early-onset preeclampsia patients undergoing TPE revealed a significant extension in pregnancy duration and reduced serum levels of sFlt-1, sFlt-1/PlGF, and sEndoglin. Here, we investigated the impact of TPE on serum sB7-H4, an immunological checkpoint molecule, and placental proteins (Flt-1, Eng, B7-H4, iNOS, TNF-α) in TPE-treated early-onset preeclampsia patients (N = 12, 23 + 2–28 + 5 weeks), conventionally treated counterparts (N = 12, 23 + 5–30 weeks), and gestational age-matched controls (N = 8, 22 + 4–31 + 6 weeks). Immunoblotting, ELISA, and co-immunohistochemistry were used for biomarker analysis, including placental inflammation factors (iNOS, TNF-α). The results showed that TPE extended pregnancy by a median of 6.5 days in this cohort of early-onset preeclampsia. Serum sB7-H4, sFlt-1, and sEndoglin levels decreased, along with reduced expression of their membrane-bound proteins in placental tissue upon TPE treatment. Moreover, TPE-treated patients displayed reduced placental inflammation compared to preeclampsia patients receiving standard-of-care treatment. In conclusion, TPE may improve pregnancy outcomes in early-onset preeclampsia by lowering circulating levels of sB7-H4, sFlt-1, and sEndoglin, as well as reducing placental inflammation. This translational approach holds promise for enhancing placental function and extending gestation in high-risk pregnancies including very preterm PE or HELLP cases. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

10. Tumor cell cytoplasmic metallothionein expression associates with differential tumor immunogenicity and prognostic outcome in high-grade serous ovarian carcinoma

Author

Mairinger, Elena, primary, Wessolly, Michael, additional, Buderath, Paul, additional, Borchert, Sabrina, additional, Henrich, Larissa, additional, Mach, Pawel, additional, Steinborn, Julia, additional, Kimming, Rainer, additional, Jasani, Bharat, additional, Schmid, Kurt Werner, additional, Bankfalvi, Agnes, additional, and Mairinger, Fabian Dominik, additional

Published
2023
Full Text
View/download PDF

21. sj-docx-1-whe-10.1177_17455065221075903 ��� Supplemental material for Ovarian cancer surgery in Germany: An analysis of the nationwide hospital file 2005���2015

Author

Trocchi, Pietro, Mach, Pawel, Kimmig, Karl Rainer, and Stang, Andreas

Subjects
FOS: Clinical medicine, 111402 Obstetrics and Gynaecology
Abstract

Supplemental material, sj-docx-1-whe-10.1177_17455065221075903 for Ovarian cancer surgery in Germany: An analysis of the nationwide hospital file 2005���2015 by Pietro Trocchi, Pawel Mach, Karl Rainer Kimmig and Andreas Stang in Women���s Health

Published
2022
Full Text
View/download PDF

24. Association of Soluble B7-H4 and Circulating Tumor Cells in Blood of Advanced Epithelial Ovarian Cancer Patients

Author

Mach, Pawel, Kimmig, Rainer, Kasimir-Bauer, Sabine, and Buderath, Paul

Subjects
epithelial ovarian cancer, endocrine system diseases, tumor micro-environment, Medizin, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, sB7-H4, female genital diseases and pregnancy complications, Medizinische Fakultät » Universitätsklinikum Essen » Klinik für Frauenheilkunde und Geburtshilfe, Oncology, circulating tumor cells (CTC), biomarker, ddc:610, RC254-282, Original Research
Abstract

Introduction: Epithelial ovarian cancer (EOC) is the deadliest gynecologic malignancy worldwide. Reliable predictive biomarkers are urgently needed to estimate the risk of relapse and to improve treatment management. Soluble immune-checkpoints in EOC are promising molecules serving as prognostic biomarkers accessible via liquid biopsy. We thus, aimed at elucidating the role of sB7-H4 in EOC. Material and Methods: We analyzed soluble serum B7-H4 (sB7-H4) using ELISA and circulating tumor cells (CTCs) in blood applying the AdnaTest OvarianCancer in 85 patients suffering from advanced EOC. Findings were correlated with clinical parameters as well as survival data. Results: sB7-H4 was detectable in 14.1% patients, CTCs in 32.9% patients and simultaneous presence of CTCs and sB7-H4 was found in 7% patients, respectively. Although no association between sB7-H4 and CTC could be documented, each of them served as independent predictive factors for overall survival (OS). Conclusion: sB7-H4 and CTCs are independent prognostic biomarkers for impaired survival in EOC. As they are easily accessible via liquid biopsy, they may be of potential benefit for the prediction of therapy response and survival for EOC patients. OA Förderung 2021

Published
2021

25. The immunological factor B7-H4 is deregulated in placenta chorionic villous and decidual basalis tissues of patients with preeclampsia and HELLP

Author

Duan, Liyan, primary, Reisch, Beatrix, additional, Iannaccone, Antonella, additional, Hadrovic, Elina, additional, Wu, Yuqing, additional, Vogtmann, Rebekka, additional, Winterhager, Elke, additional, Kimmig, Rainer, additional, Köninge, Angela, additional, Mach, Pawel, additional, and Gellhaus, Alexandra, additional

Published
2021
Full Text
View/download PDF

26. Abnormal expression of the costimulatory molecule B7‐H4 in placental chorionic villous and decidual basalis tissues of patients with preeclampsia and HELLP syndrome

Author

Duan, Liyan, primary, Reisch, Beatrix, additional, Iannaccone, Antonella, additional, Hadrovic, Elina, additional, Wu, Yuqing, additional, Vogtmann, Rebekka, additional, Winterhager, Elke, additional, Kimmig, Rainer, additional, Köninger, Angela, additional, Mach, Pawel, additional, and Gellhaus, Alexandra, additional

Published
2021
Full Text
View/download PDF

31. Evaluation of carcinoembryonic antigen‐related cell adhesion molecule 1 blood serum levels in women at high risk for preeclampsia

Author

Mach, Pawel, primary, Andrikos, Dimitrios, additional, Schmidt, Boerge, additional, Gellhaus, Alexandra, additional, Rusch, Peter, additional, Birdir, Cahit, additional, Andrikos, Argyrios, additional, Schmitt, Verena, additional, Kimmig, Rainer, additional, Singer, Bernhard B., additional, and Köninger, Angela, additional

Published
2020
Full Text
View/download PDF

34. Soluble PD‐L1 and B7‐H4 serum levels during the course of physiological pregnancy.

Author

Mach, Pawel, Köninger, Angela, Reisch, Beatrix, Kimmig, Rainer, and Gellhaus, Alexandra

Subjects
*PROGRAMMED death-ligand 1, *MATERNALLY acquired immunity, *ENZYME-linked immunosorbent assay, *PREGNANCY, *THIRD trimester of pregnancy
Abstract

Problem: The aim of this study was to evaluate the soluble programmed death‐ligand (sPD‐L1) and soluble B7‐H4 (sB7‐H4) serum concentration levels longitudinal throughout the three trimesters of uncomplicated pregnancies. Method of the study: sPD‐L1 and sB7‐H4 levels were determined with enzyme‐linked immunosorbent assay (ELISA). The patients (n = 26) were divided into three groups according to the pregnancy trimester. Among 26 women involved in the study 14 had longitudinal sB7‐H4 and sPD‐L1 measurements in each trimester of pregnancy. Results: During the course of pregnancy, the sB7‐H4 blood serum levels were significant higher in second trimester than in first and third trimester, whereas sPD‐L1 levels increased significantly over the course of pregnancy. Conclusion: The highest serum levels of sPD‐L1 in the third trimester suggest increasing suppression of maternal immunity throughout pregnancy, whereas elevated sB7‐H4 concentration levels in second trimester suggests different profile of T‐cell regulation in physiological pregnancy. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

36. Digital Immune-Related Gene Expression Signatures In High-Grade Serous Ovarian Carcinoma: Developing Prediction Models For Platinum Response

Author

Mairinger, Fabian, Bankfalvi, Agnes, Schmid, Kurt Werner, Mairinger, Elena, Mach, Pawel, Walter, Robert F. H., Borchert, Sabrina, Kasimir-Bauer, Sabine, Kimmig, Rainer, and Buderath, Paul

Subjects
Medizinische Fakultät » Universitätsklinikum Essen » Institut für Pathologie und Neuropathologie, ovarian cancer -- tumor microenvironment -- predictive biomarkers -- platinumresistance -- HGSOC -- gene expression signatures, endocrine system diseases, Cancer Management and Research, Medizinische Fakultät » Universitätsklinikum Essen » Ruhrlandklinik Essen – Universitätsklinik, Medizin, ddc:610, Medizinische Fakultät » Universitätsklinikum Essen » Klinik für Frauenheilkunde und Geburtshilfe
Abstract

Fabian Mairinger,1 Agnes Bankfalvi,1 Kurt Werner Schmid,1 Elena Mairinger,2 Pawel Mach,3 Robert FH Walter,2 Sabrina Borchert,1 Sabine Kasimir-Bauer,3 Rainer Kimmig,3 Paul Buderath3 1Institute for Pathology, University Hospital Essen, Essen, Germany; 2Ruhrlandklinik, West German Lung Centre, University Hospital Essen, University of Duisburg-Essen, Essen, Germany; 3Department of Gynecology and Obstetrics, University Hospital Essen, Essen, GermanyCorrespondence: Paul BuderathDepartment of Gynecology and Obstetrics, University Hospital Essen, Hufelandstraße 55, Essen 45122, GermanyTel +49 201 723 2442Email paul.buderath@uk-essen.dePurpose: Response to platinum-based therapy is a major prognostic factor in high-grade serous ovarian cancer (HGSOC). While the exact mechanisms of platinum-resistance remain unclear, evidence is accumulating for a connection between the organism’s immune-response and response to platinum. However, predictive tools are missing. This study was performed to examine the putative role of the genetic tumor immune-microenvironment in mediating differential chemotherapy response in HGSOC patients.Patients and methods: Expression profiling of 770 immune-related genes was performed in tumor tissues from 23 HGSOC cases. Tumors were screened for prognostic and predictive biomarkers using the NanoString nCounter platform for digital gene expression analysis with the appurtenant PanCancer Immune Profiling panel. As validation cohort, gene expression data (RNA Seq) of 303 patients with epithelial ovarian carcinoma (EOC) were retrieved from the The Cancer Genome Atlas (TCGA) database. Different scoring-systems were computed for prediction of risk-of-resistance to cisplatin, disease-free survival (DFS) and overall survival (OS).Results: Validated on the TCGA-dataset, the developed scores identified 11 significantly differentially expressed genes (p

Published
2019

37. Chirurgische Versorgung von Patientinnen mit Eierstockkrebs (ICD-10: C56) in Deutschland: Eine Analyse der DRG-Statistik 2005-2015

Author

Trocchi, Pietro, Mach, Pawel, and Stang, Andreas

Subjects
Eierstockkrebs, ddc: 610, DRG-Statistik, 610 Medical sciences, Medicine, Chirurgische Behandlung
Abstract

Ziel: Krankenhausbasierte Informationen über die chirurgische Behandlung von Eierstockkrebs sind gering in der Literatur. Wir untersuchten Art der Operation, OP-Zugang, Verweildauer, die häufigsten chirurgischen Komplikationen und stationäre Mortalität bei Frauen mit Eierstockkrebs[zum vollständigen Text gelangen Sie über die oben angegebene URL], 64. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e.V. (GMDS)

Published
2019

38. Cell-Free DNA Variant Sequencing Using CTC-Depleted Blood for Comprehensive Liquid Biopsy Testing in Metastatic Breast Cancer

Author

Keup, Corinna, Storbeck, Markus, Hauch, Siegfried, Hahn, Peter, Sprenger-Haussels, Markus, Tewes, Mitra, Mach, Pawel, Hoffmann, Oliver, Kimmig, Rainer, and Kasimir-Bauer, Sabine

Subjects
cell-free DNA, Medizinische Fakultät » Universitätsklinikum Essen » Innere Klinik (Tumorforschung), liquid biopsy, Medizin, ddc:61, next-generation sequencing, ddc:610, metastatic breast cancer, circulating tumor cells, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, lcsh:RC254-282, Medizinische Fakultät » Universitätsklinikum Essen » Klinik für Frauenheilkunde und Geburtshilfe
Abstract

Liquid biopsy analytes such as cell-free DNA (cfDNA) and circulating tumor cells (CTCs) exhibit great potential for personalized treatment. Since cfDNA and CTCs are considered to give additive information and blood specimens are limited, isolation of cfDNA and CTC in an &ldquo, all from one tube&rdquo, format is desired. We investigated whether cfDNA variant sequencing from CTC-depleted blood (CTC-depl. B, obtained after positive immunomagnetic isolation of CTCs (AdnaTest EMT-2/Stem Cell Select, QIAGEN)) impacts the results compared to cfDNA variant sequencing from matched whole blood (WB). Cell-free DNA was isolated using matched WB and CTC-depl. B from 17 hormone receptor positive/human epidermal growth factor receptor 2 negative (HR+/HER2&minus, ) metastatic breast cancer patients (QIAamp MinElute ccfDNA Kit, QIAGEN). Cell-free DNA libraries were constructed (customized QIAseq Targeted DNA Panel for Illumina, QIAGEN) with integrated unique molecular indices. Sequencing (on the NextSeq 550 platform, Illumina) and data analysis (Ingenuity Variant Analysis) were performed. RNA expression in CTCs was analyzed by multimarker quantitative PCR. Cell-free DNA concentration and size distribution in the matched plasma samples were not significantly different. Seventy percent of all variants were identical in matched WB and CTC-depl. B, but 115/125 variants were exclusively found in WB/CTC-depl. B. The number of detected variants per patient and the number of exclusively detected variants per patient in only one cfDNA source did not differ between the two matched cfDNA sources. Even the characteristics of the exclusively detected cfDNA variants in either WB or CTC-depl. B were comparable. Thus, cfDNA variants from matched WB and CTC-depl. B exhibited no relevant differences, and parallel isolation of cfDNA and CTCs from only 10 mL of blood in an &ldquo, format was feasible. Matched cfDNA mutational and CTC transcriptional analyses might empower a comprehensive liquid biopsy analysis to enhance the identification of actionable targets for individual therapy strategies.

Published
2019

41. Evaluation of carcinoembryonic antigen‐related cell adhesion molecule 1 blood serum levels in women at high risk for preeclampsia.

Author

Mach, Pawel, Andrikos, Dimitrios, Schmidt, Boerge, Gellhaus, Alexandra, Rusch, Peter, Birdir, Cahit, Andrikos, Argyrios, Schmitt, Verena, Kimmig, Rainer, Singer, Bernhard B., and Köninger, Angela

Subjects
*CELL adhesion molecules, *THIRD trimester of pregnancy, *PREECLAMPSIA, *PREGNANT women
Abstract

Problem: The aim of this study was to evaluate the sCEACAM1 concentrations in serum from patients in the first trimester who have a high risk for developing PE during pregnancy. Method of the study: Carcinoembryonic antigen‐related cell adhesion molecule 1 (CEACAM1) levels were determined with ELISA. The patients (n = 109) were divided into two groups: patients who have a high risk of developing PE early‐onset and a control group. Patients who have a high risk of developing PE were then divided into two subgroups depending on PE development in third trimester of pregnancy: PE in third trimester versus no PE in third trimester. Results: sCEACAM1 concentrations in patients who were screened as having a high risk for developing PE were significantly higher than in healthy pregnant women in the first trimester (p =.03). The highest sCEACAM1 concentration was found in the high‐risk group with PE development compared to the control group (p =.004). Conclusion: Elevated sCEACAM1 blood serum levels in women with PE suggest that there is immune dysregulation in early pregnancy, which may be helpful in PE prediction and therapy. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

44. 118. Significant increase of soluble B7-H4 in women at high-risk for preeclampsia in the first trimester: A potential immunological biomarker for immunologically-mediated pregnancy complications?

Author

Gellhaus, Alexandra, primary, Mach, Pawel, additional, Nolte-Bönigk, Louisa, additional, Droste, Leonie, additional, Fox, Laura, additional, Frank, Mirjam, additional, Schmidt, Börge, additional, Herse, Florian, additional, Verlohren, Stefan, additional, Wicherek, Lukasz, additional, Iannaccone, Antonella, additional, Birdir, Cahit, additional, Andrikos, Dimitrios, additional, Kimmig, Rainer, additional, and Köninger, Angela, additional

Published
2018
Full Text
View/download PDF

48. Soluble B7-H4 blood serum levels are elevated in women at high risk for preeclampsia in the first trimester, as well as in patients with confirmed preeclampsia

Author

Mach, Pawel, primary, Nolte-Boenigk, Luisa, additional, Droste, Leonie, additional, Fox, Laura, additional, Frank, Mirjam, additional, Schmidt, Boerge, additional, Herse, Florian, additional, Verlohren, Stefan, additional, Wicherek, Lukasz, additional, Iannaccone, Antonella, additional, Birdir, Cahit, additional, Andrikos, Dimitrios, additional, Kimmig, Rainer, additional, Gellhaus, Alexandra, additional, and Köninger, Angela, additional

Published
2018
Full Text
View/download PDF

50. Abstract 3777: RNA profiles of circulating tumor cells and extracellular vesicles for therapy stratification of metastatic breast cancer patients

Author

Keup, Corinna, primary, Hauch, Siegfried, additional, Plappert, Linda, additional, Sprenger-Haussels, Markus, additional, Mach, Pawel, additional, Tewes, Mitra, additional, Aktas, Bahriye, additional, Kolberg, Hans-Christian, additional, Kimmig, Rainer, additional, and Kasimir-Bauer, Sabine, additional

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results