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716 results on '"MA Jinghong"'

1. A 95 GeV Higgs boson and spontaneous CP-violation at the finite temperature

Author

Gao, Jing, Ma, Jinghong, Wang, Lei, and Xu, Haotian

Subjects
High Energy Physics - Phenomenology
Abstract

The ATLAS and CMS collaborations reported a diphoton excess in the invariant mass distribution around the 95.4 GeV with a local significance of $3.1\sigma$. Moreover, there is another $2.3\sigma$ local excess in the $b\bar{b}$ final state at LEP in the same mass region. A plausible solution is that the Higgs sector is extended to include an additional Higgs boson with a mass of $95.4$ GeV. We study a complex singlet scalar extension of the two-Higgs-doublet model in which the 95.4 GeV Higgs is from the mixing of three CP-even Higgs fields. In addition, the extended Higgs potential can achieve spontaneous CP-violation at the finite temperature and restore CP symmetry at the present temperature of the Universe. We find that the model can simultaneously explain the baryon asymmetry of the Universe, the diphoton and $b\bar{b}$ excesses around the 95.4 GeV while satisfying various relevant constraints including the experiments of collider and electric dipole moment., Comment: 28 pages, 8 figures, 1 tables, add references. arXiv admin note: text overlap with arXiv:2311.02828

Published
2024

3. Electroweak baryogenesis, dark matter, and dark CP-symmetry

Author

Ma, Jinghong, Wang, Jie, and Wang, Lei

Subjects
High Energy Physics - Phenomenology, Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Experiment
Abstract

With the motivation of explaining the dark matter and achieving the electroweak baryogenesis via the spontaneous CP-violation at high temperature, we propose a complex singlet scalar ($S=\frac{\chi+i\eta_s}{\sqrt{2}}$) extension of the two-Higgs-doublet model respecting a discrete dark CP-symmetry: $S\to -S^*$. The dark CP-symmetry guarantees $\chi$ to be a dark matter candidate on one hand and on the other hand allows $\eta_s$ to have mixings with the pseudoscalars of the Higgs doublet fields, which play key roles in generating the CP-violation sources needed by the electroweak baryogenesis at high temperature. The universe undergoes multi-step phase transitions, including a strongly first-order electroweak phase transition during which the baryon number is produced. At the present temperature, the observed vacuum is produced and the CP-symmetry is restored so that the stringent electric dipole moment experimental bounds are satisfied. Considering relevant constraints, we study the simple scenario of $m_{\chi}$ around the Higgs resonance region, and find that the dark matter relic abundance and the baryon asymmetry can be simultaneously explained. Finally, we briefly discuss the gravitational wave signatures at future space-based detectors and the LHC signatures., Comment: typos fixed, references added

Published
2023

8. The $U(1)_{L_\mu-L_\tau}$ breaking phase transition, muon $g-2$, dark matter, collider and gravitational wave

Author

Wang, Jie, Ma, Jinghong, Gao, Jing, Han, Xiao-Fang, and Wang, Lei

Subjects
High Energy Physics - Phenomenology
Abstract

Combining the dark matter and muon $g-2$ anomaly, we study the $U(1)_{L_\mu-L_\tau}$ breaking phase transition, gravitational wave spectra, and the direct detection at the LHC in an extra $U(1)_{L_\mu-L_\tau}$ gauge symmetry extension of the standard model. The new fields includes vector-like leptons ($E_1,~ E_2,~ N$), $U(1)_{L_\mu-L_\tau}$ breaking scalar $S$ and gauge boson $Z'$, as well as the dark matter candidate $X_I$ and its heavy partner $X_R$. A joint explanation of the dark matter relic density and muon $g-2$ anomaly excludes the region where both $min(m_{E_1},m_{E_2},m_N,m_{X_R})$ and $min(m_{Z'},m_S)$ are much larger than $m_{X_I}$. In the parameter space accommodating the DM relic density and muon $g-2$ anomaly, the model can achieve a first order $U(1)_{L_\mu-L_\tau}$ breaking phase transition, whose strength is sensitive to the parameters of Higgs potential. The corresponding gravitational wave spectra can reach the sensitivity of U-DECIGO. In addition, the direct searches at the LHC impose stringent bound on the mass spectra of the vector-like leptons and dark matter., Comment: 21 pages, 4 figures, 2 tables

Published
2023

16. Genome-wide association study using whole-genome sequencing identifies risk loci for Parkinson’s disease in Chinese population

Author

Pan, Hongxu, Liu, Zhenhua, Ma, Jinghong, Li, Yuanyuan, Zhao, Yuwen, Zhou, Xiaoxia, Xiang, Yaqin, Wang, Yige, Zhou, Xun, He, Runcheng, Xie, Yali, Zhou, Qiao, Yuan, Kai, Xu, Qian, Sun, Qiying, Wang, Junling, Yan, Xinxiang, Zhang, Hainan, Wang, Chunyu, Lei, Lifang, Liu, Weiguo, Wang, Xuejing, Ding, Xuebing, Wang, Tao, Xue, Zheng, Zhang, Zhentao, Chen, Ling, Wang, Qing, Liu, Yonghong, Tang, Jiayu, Zhang, Xuewei, Peng, Shifang, Wang, Chaodong, Ding, Jianqing, Liu, Chunfeng, Wang, Lijuan, Chen, Haibo, Shen, Lu, Jiang, Hong, Wu, Xinyin, Tan, Hongzhuan, Luo, Dan, Xiao, Shuiyuan, Chen, Xiang, Tan, Jieqiong, Hu, Zhengmao, Chen, Chao, Xia, Kun, Zhang, Zhuohua, Foo, Jia Nee, Blauwendraat, Cornelis, Nalls, Mike A., Singleton, Andrew B., Liu, Jun, Chan, Piu, Zheng, Houfeng, Li, Jinchen, Guo, Jifeng, Yang, Jian, and Tang, Beisha

Published
2023
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22. Vibrotactile Foot Device for Freezing of Gait in Parkinson's Disease: A Pilot Study.

Author

Cen, Shanshan, Ma, Jinghong, Sun, Hong, Zhang, Hui, Li, Yuan, Mao, Wei, Xu, Erhe, Mei, Shanshan, Chhetri, Jagadish K., Ruan, Zheng, Wang, Hui, Wang, Kailiang, and Chan, Piu

Subjects
*GAIT disorders, *PARKINSON'S disease, *MOVEMENT disorders, *GAIT in humans, *PATIENTS' attitudes, *VIBROTACTILE stimulation
Abstract

Background: Vibrotactile stimulation has been studied in its efficacy of reducing freezing of gait (FOG) in patients with Parkinson's disease (PD). However, the results are still controversial. We evaluated the efficacy of a newly developed vibrotactile foot device on freezing severity and gait measures in PD patients with FOG. Objective: To evaluate the efficacy of vibrotactile foot device on PD patients with FOG. Methods: Thirty‐three PD patients with FOG were examined during their "off" medication state. The efficacy of the vibrotactile foot device was evaluated using a gait protocol comprising walking trials with vibrotactile stimulation "off" and "on." Walking trials were videotaped for the offline rating by two movement disorder specialists. The Opal inertial sensor unit (128 Hz; Mobility Lab; APDM Inc., Portland, OR, USA) was used for quantitative gait analysis. Results: The results demonstrated 33.1% reduction in number of FOG episodes (P < 0.001) and 32.6% reduction of freezing episodes (P < 0.001). Quantitative gait analysis showed a significant increase in step length (P = 0.033). A moderate negative correlation was observed between the change of percent time frozen and age (r = −0.415, P = 0.016). 73% of participants reported minimal to substantial improvement in walking with this vibrating stimulation delivered by the vibrotactile foot device. Conclusions: The vibrotactile foot device is an efficient device that could significantly reduce freezing severity and provide gait regulation to patients with PD experiencing frequent freezing. It could potentially be used in the home environment for improving the quality of life. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Deficiency in endocannabinoid synthase DAGLB contributes to early onset Parkinsonism and murine nigral dopaminergic neuron dysfunction

Author

Liu, Zhenhua, Yang, Nannan, Dong, Jie, Tian, Wotu, Chang, Lisa, Ma, Jinghong, Guo, Jifeng, Tan, Jieqiong, Dong, Ao, He, Kaikai, Zhou, Jingheng, Cinar, Resat, Wu, Junbing, Salinas, Armando G., Sun, Lixin, Kumar, Mantosh, Sullivan, Breanna T., Oldham, Braden B., Pitz, Vanessa, Makarious, Mary B., Ding, Jinhui, Kung, Justin, Xie, Chengsong, Hawes, Sarah L., Wang, Lupeng, Wang, Tao, Chan, Piu, Zhang, Zhuohua, Le, Weidong, Chen, Shengdi, Lovinger, David M., Blauwendraat, Cornelis, Singleton, Andrew B., Cui, Guohong, Li, Yulong, Cai, Huaibin, and Tang, Beisha

Published
2022
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26. Nontuberculous mycobacterial pulmonary disease and associated risk factors in China: A prospective surveillance study

Author

Tan, Yaoju, Deng, Yunfeng, Yan, Xiaofeng, Liu, Fangchao, Tan, Yunhong, Wang, Quan, Bao, Xundi, Pan, Jianhua, Luo, Xiaolu, Yu, Yanhong, Cui, Xiaoli, Liao, Guangfu, Ke, Chunmei, Xu, Ping, Li, Xiaofei, Zhang, Chunlei, Yao, Xiangyang, Xu, Ye, Li, Tongxin, Su, Biyi, Chen, Zhenhua, Ma, Ruiying, Jiang, Yue, Ma, Xiaohua, Bi, Dewu, Ma, Jinghong, Yang, Han, Li, Xuezheng, Tang, Liusheng, Yu, Yongmin, Wang, Yufeng, Song, Huafeng, Liu, Hongwei, Wu, Meiling, Yang, Yinghui, Xue, Zhongtan, Li, Liang, Li, Qingge, and Pang, Yu

Published
2021
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27. Levodopa modulates semantic fluency and uniqueness in non‐demented patients with progressive supranuclear palsy.

Author

Ma, Jinghong, Zhang, Guanyu, Zhao, Zhenzhen, Chan, Piu, and Ye, Zheng

Subjects
*PROGRESSIVE supranuclear palsy, *PARKINSON'S disease, *EXECUTIVE function, *SHORT-term memory, *COGNITION disorders
Abstract

Introduction: Semantic fluency is the ability to name items from a given category within a limited time, which relies on semantic knowledge, working memory, and executive function. Similar to patients with Parkinson's disease (PD), patients with progressive supranuclear palsy (PSP) scored lower than healthy adults in the well‐established semantic fluency test. However, it is unclear how unique are the produced words. This study examined the relationship between semantic fluency and words' uniqueness in patients with PSP. Methods: Twenty‐seven patients with PSP Richardson's syndrome (PSP‐RS), 37 patients with PD, and 41 healthy controls (HC) performed a standard semantic fluency test (animals), and their verbal responses were audio‐recorded. We used the uniqueness to reflect the ability to produce both original and effective work, that is, creativity. Results: The PSP‐RS group produced fewer correct words and fewer unique words than the PD and HC groups. Moreover, the correlation between fluency and uniqueness was positive in the HC and PD groups but negative in the PSP‐RS group. Importantly, the actual levodopa dose was positively correlated with the fluency but negatively correlated with the uniqueness in PSP‐RS. The PSP‐RS patients who took a greater dose of levodopa tended to produce more correct words but fewer unique words. Conclusions: These results suggested that levodopa may modulate semantic fluency and uniqueness in the early stages of PSP‐RS. [ABSTRACT FROM AUTHOR]

Published
2024
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46. Impaired sequence manipulation in non‐demented patients with progressive supranuclear palsy.

Author

Zhang, Guanyu, Ma, Jinghong, Chan, Piu, and Ye, Zheng

Subjects
*PROGRESSIVE supranuclear palsy, *DOPA, *MEMORY span, *PARKINSON'S disease, *NEUROPSYCHOLOGICAL tests, *SHORT-term memory
Abstract

Purpose: Sequential working memory is the ability to maintain and manipulate sequential information at a second time scale. Patients with progressive supranuclear palsy (PSP) or Parkinson's disease (PD) perform poorly in tests that require the flexible arrangement of thoughts or actions. This study investigated whether sequential working memory is differently impaired in patients with PSP versus PD. Method: Twenty‐nine patients with PSP Richardson's syndrome (PSP‐RS), 36 patients with PD, and 36 healthy controls (HC) completed 3 well‐established neuropsychological tests, including digit span forward (DST‐F), digit span backward (DST‐B), and adaptive digit ordering tests (DOT‐A). The DST‐F required maintaining digit sequences, and the DST‐B and DOT‐A required maintaining and manipulating digit sequences. Finding: The PSP‐RS group scored lower than the PD and HC groups in the DST‐B and DOT‐A but not in the DST‐F, indicating that the ability to manipulate sequences was impaired, but the maintenance ability was preserved in PSP‐RS patients. Moreover, in PSP‐RS, the DST‐B score negatively correlated with the severity of motor symptoms. The actual levodopa dose positively correlated with the DST‐B ordering cost (DST‐F score vs. DST‐B score). The PSP patients who took a greater dose of levodopa tended to have higher DST‐B ordering cost. There was no effect of levodopa on DST‐B or DOT‐A in PD. Conclusion: These results suggested that the ability to manipulate sequence was already reduced in patients with PSP‐RS and was worse than in patients with PD. [ABSTRACT FROM AUTHOR]

Published
2024
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