10 results on '"MA Asafa"'
Search Results
2. Protective Effect of Kolaviron on Cyclophosphamide-Induced Cardiac Toxicity in Rats
- Author
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Benson Akinloye Fadeyi, Modinat A. Adefisayo, MA Asafa, Quadri K. Alabi, Joseph Gbenga Omole, Oladele A. Ayoka, and Babalola Olusegun Olubunmi
- Subjects
Male ,antioxidant ,Antioxidant ,medicine.medical_treatment ,lcsh:RX1-681 ,030204 cardiovascular system & hematology ,Pharmacology ,medicine.disease_cause ,030226 pharmacology & pharmacy ,chemistry.chemical_compound ,0302 clinical medicine ,lcsh:Homeopathy ,Malondialdehyde ,biology ,lcsh:Other systems of medicine ,Glutathione ,Nitrogen mustard ,Leukemia ,Seeds ,Original Article ,medicine.drug ,cardiac troponin I ,Cyclophosphamide ,cardiotoxicity ,Garcinia kola ,Protective Agents ,03 medical and health sciences ,medicine ,Animals ,Humans ,Rats, Wistar ,kolaviron ,Antineoplastic Agents, Alkylating ,Flavonoids ,Cardiotoxicity ,Plant Extracts ,Superoxide Dismutase ,business.industry ,medicine.disease ,biology.organism_classification ,lcsh:RZ201-999 ,Rats ,Oxidative Stress ,Complementary and alternative medicine ,chemistry ,cyclophosphamide ,business ,Oxidative stress - Abstract
Background.Cyclophosphamide (CP) is a nitrogen mustard alkylating drug used for the treatment of chronic and acute malignant lymphomas, myeloma, leukemia, neuroblastoma, adenocarcinoma, retinoblastoma, breast carcinoma, and immunosuppressive therapy. Despite its vast therapeutic uses, it is known to cause severe cardiac toxicity. Kolaviron (KV), a Garcinia kola seed extract containing a mixture of flavonoids, is reputed for its antioxidant and membrane stabilizing properties.Objective.This study investigated the protective effect of KV on CP-induced cardiotoxicity in rats.Methods.Thirty rats were used, and they were divided into 6 groups of 5 rats each. Group I received 2 mL/kg propylene glycol orally for 14 days; group II received CP (50 mg/kg/d, intraperitoneally [i.p.]) for 3 days; groups III and IV received 200 and 400 mg/kg/d KV, respectively, orally for 14 days and groups V and VI were pretreated with 200 and 400 mg/kg/d KV, respectively, orally for 14 days followed by CP (50 mg/kg/d, i.p.) for 3 days.Results.CP treatment resulted in a significantly lower food consumption and body weight in rats. The lactate dehydrogenase and creatine kinase enzymes in cardiac tissues of rats treated with CP were significantly higher. In cardiac tissues, 3-day doses of CP resulted in significantly higher heart weight, cardiac troponin I, myeloperoxidase, malondialdehyde, hydrogen peroxide and lower superoxide dismutase, catalase, glutathione peroxidase activities, and reduced glutathione levels. Histological examination of cardiac tissues showed sign of necrosis of myocardium after CP treatment. However, administration of KV at 200 and 400 mg/kg for 14 days prior to CP treatment, increase food consumption, body weight, and attenuates the biochemical and histological changes induced by CP.Conclusions.These results revealed that KV attenuates CP-induced cardiotoxicity by inhibiting oxidative stress and preserving the activity of antioxidant enzymes.
- Published
- 2018
3. Effect of Abo Blood Group on Blood Pressure Indices among Apparently Healthy Young Adults of Yoruba Ethnicity in Ile-Ife
- Author
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MA, Asafa, primary, O, Ogunlade, additional, and RA, Bolarinwa, additional
- Published
- 2018
- Full Text
- View/download PDF
4. Pattern and prevalence of underweight, overweight and obesity among market women in South-West Nigeria
- Author
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Oluwadare Ogunlade, O Ogunlade, and MA Asafa
- Subjects
Health consequences ,business.industry ,Abnormal BMI ,nutritional and metabolic diseases ,Overweight ,medicine.disease ,Obesity ,World health ,Age groups ,Abnormal body mass index ,medicine ,Underweight ,medicine.symptom ,business ,Demography - Abstract
Background: Abnormal body mass index (BMI) is known to result in serious health consequences. Objective: The present study aimed at determining the pattern and prevalence of underweight, overweight and obesity among market women at Ile-Ife. Methods: The participants had their weight and height recorded by standardised techniques, and BMI was calculated from the weight and height. BMI was classified according to the World Health Organization criteria. The average income per day (AIPD) for each participant was estimated as the average sum of daily profit earned on goods and services. Data were analysed using descriptive and inferential statistics. Results: Nine hundred and three market women participated in the present study. The age range was 18–95 years with 41.7% between 18 and 40 years, 43.0% between 41 and 64 years and 15.3% were 65 years and above. The mean of age and BMI of the participants were 46.3 (15.1) years and 28.5 (5.4) kg/m2, respectively. Only 23.3% of the women had normal BMI. The prevalence of underweight, overweight and obesity was 1.7%, 38.5% and 36.5%, respectively. The distribution of overweight and obesity among age groups 18–40 years, 41–64 years and 65 years and above was 40.6% and 30.2%; 38.7% and 41.7% and 32.6% and 39.1%, respectively. There was a significant association (χ2 = 7.177, P = 0.028) between AIPD and BMI classes. Conclusion: This study showed a high prevalence of abnormal BMI among market women in Ile-Ife. Overweight and obesity constitute a major health burden among market women.
- Published
- 2016
5. Evaluation of electrocardiogram as a biological signal for sex verification among fresh undergraduates in a Nigerian tertiary institution
- Author
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MA Asafa, Owen E Osasogie, A. O. Ayoka, and Oluwadare Ogunlade
- Subjects
medicine.medical_specialty ,Scoring system ,Receiver operating characteristic ,business.industry ,Tertiary institution ,030204 cardiovascular system & hematology ,Predictive value ,Confidence interval ,03 medical and health sciences ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Internal medicine ,Area under curve ,medicine ,Standard protocol ,False positive paradox ,business - Abstract
Background: Sex verification using electrocardiogram (ECG) is a new application of the biological signal. Objective: This study aimed to determine the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of an electrocardiographic score in sex verification. Methods: A total of 2442 apparently healthy fresh undergraduates who presented for health screening in a tertiary institution were recruited for the study. The technical team documented the sex of the participants and had their resting 12-lead ECG recorded according to standard protocol. Two physicians who were blinded to the participants and the recorded sex utilized Ogunlade Sex Determination Electrocardiographic Score (OSDES) to determine the sex. The validity of OSDES was estimated using sex recorded by the technical team as the standard while the accuracy of scoring system was determined using receiver operating characteristic curve. Results: The mean (± standard deviation) of age of the participants was 20.71 ± 3.62 years. Among the male population, true positives (TPs), false positives (FPs), false negatives (FNs), and true negatives (TN) were 1131, 49, 90, and 1172, respectively. Among the females TP, FP, FN, and TN were 1172, 90, 49, and 1131, respectively. Among males, the sensitivity, specificity, PPV, and NPV were 92.63% (95% confidence interval [CI]: 91.02-94.03%), 95.99% (95% CI: 94.73-97.02%), 95.85% (95% CI: 94.55-96.91%), and 92.87% (CI: 91.31-94.23%) respectively while among the females, the sensitivity, specificity, PPV, and NPV were 95.99% (95% CI: 94.73-97.02%), 92.63% (95% CI: 91.02-94.03%), 92.87% (95% CI: 91.31-94.23%), and 95.85% (95% CI: 91.02-94.03%) respectively. The area under curve was 0.943. Conclusion: This study concluded that ECG has a reasonable level of sensitivity and specificity with excellent accuracy in verification of sex among fresh Nigerian undergraduates.
- Published
- 2016
6. Challenges of body mass index classification: New criteria for young adult Nigerians
- Author
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Oluwadare Ogunlade, MA Asafa, and Olusoji Adeola Adalumo
- Subjects
Pediatrics ,medicine.medical_specialty ,Percentile ,Nigerians ,nutritional and metabolic diseases ,Overweight ,medicine.disease ,Obesity ,Geography ,medicine ,Cutoff ,Underweight ,medicine.symptom ,Young adult ,Body mass index - Abstract
Background: There are evidences to suggest that the World Health Organization (WHO) general cutoff points for body mass index (BMI) may not be the most appropriate for young adults globally irrespective of racial and ethnic considerations. Objective: This study assessed body anthropometric parameters in healthy population of young adult Nigerians with a view to determining race and gender-specific criteria (Ife criteria) for BMI classification. Methods: Four hundred and eighty-four (242 males and 242 females) healthy subjects aged between 18 and 41 years (inclusive) were recruited for the study. The participants were age- and sex-matched (mean age: 22.81 ± 3.83 years). The weight and height of the subjects were obtained using standard techniques while BMI was calculated as derivatives of height and weight. The BMI was classified using 5 th , 85 th , and 95 th percentiles and delineated into underweight ( 95 th percentile). Results: The result showed that the general BMI cutoff values for underweight, normal, overweight, and obesity were Conclusions: The cutoff values for the new criteria for BMI classification were lower than the WHO defined values and sex differences were demonstrated in BMI. Therefore, WHO criteria may not be universally applicable.
- Published
- 2015
7. The role of electrocardiogram in the diagnosis of dextrocardia with mirror image atrial arrangement and ventricular position in a young adult Nigerian in Ile-Ife: a case report
- Author
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Adedayo I. Irinoye, Rufus O. Akomolafe, A. O. Ajao, Olumide S. Akinsomisoye, MA Asafa, A. O. Ayoka, and Oluwadare Ogunlade
- Subjects
Male ,medicine.medical_specialty ,Black People ,Nigeria ,Cardiomegaly ,Case Report ,Dextrocardia ,Inferior vena cava ,Apex beat ,Diagnosis, Differential ,Electrocardiography ,Young Adult ,QRS complex ,Right ventricular hypertrophy ,Internal medicine ,Abdomen ,medicine ,Humans ,Ultrasonography ,Medicine(all) ,Incidental Findings ,medicine.diagnostic_test ,Nigerian ,business.industry ,General Medicine ,Situs Inversus ,medicine.disease ,Precordium ,Electrocardiogram ,Surgery ,Viscera ,Situs inversus ,medicine.anatomical_structure ,medicine.vein ,Cardiology ,cardiovascular system ,business - Abstract
Introduction Dextrocardia with situs inversus is a rare congenital disease. In patients with this condition, the heart is presented as a mirror image of itself with its apex pointing to the right. The pulmonary and abdominal anatomies are reversed. Dextrocardia with situs inversus occurs at birth but its diagnosis may be in adulthood. This case advances knowledge by graphically describing the unusual electrocardiographic features of dextrocardia in a young adult. Case presentation We report a case of a 22-year-old Nigerian man of Yoruba ethnicity who presented himself for preadmission medical test. He had a standard 12-lead electrocardiogram which revealed uncommon features: inversion of P waves in leads I, aVL and aVR; dominantly negative QRS waves in leads I, V1 to V6; reverse R wave progression in chest leads; low voltage in V4 to V6; extreme QRS axis; flattened T waves in V4 to V6 and aVR; and inverted T waves in lead I and aVL. An electrocardiogram diagnosis of dextrocardia was made. The differential diagnosis considered was right ventricular hypertrophy. A cardiovascular examination showed pulse rate of 70 beats per minute, blood pressure of 119/62mmHg, visible cardiac impulse at right precordium, apex beat was located at his fifth right intercostal space mid-clavicular line. A chest X-ray (posterior anterior view) including upper abdomen showed dextrocardia; his aortic arch was located on the right. His stomach bubble was located below his right hemidiaphragm. His trachea was slightly deviated to the left. The findings in his lung fields were not remarkable. Abdominopelvic ultrasonography showed that right-sided intra-abdominal organs (liver, gallbladder) were located on the left while left-sided organs (stomach, spleen) were located on the right. His abdominal aorta was on the right while his inferior vena cava was located on the left. A diagnosis of dextrocardia with situs inversus was made ultrasonographically. Conclusions A properly interpreted electrocardiogram was useful in suspecting the diagnosis of dextrocardia with situs inversus. So, an analysis of a relatively simple and non-invasive diagnostic tool such as an electrocardiogram allows for suspicion of a cardiovascular anomaly in a setting of scarce diagnostic resources.
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8. The role of electrocardiogram in sex verification in a young adult with primary amenorrhea: a case report.
- Author
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Asafa MA, Bolarinwa RA, Eluwole OA, Ibitoye BO, Adegoke AM, and Ogunlade O
- Subjects
- Adult, Amenorrhea genetics, Female, Genitalia, Female diagnostic imaging, Humans, Karyotyping, Male, Testis diagnostic imaging, Ultrasonography, Cryptorchidism diagnostic imaging, Electrocardiography, Sex Determination Analysis
- Abstract
Background: The use of electrocardiogram for sex verification in adults is an emerging concept in medicine. It is feasible through the utilization of Ogunlade Sex Determination Electrocardiographic Score. The aim of this study was to use an electrocardiogram to verify the sex of a woman with primary amenorrhea., Case Presentation: We report a case of a 36-year-old woman of Yoruba ethnicity who presented with primary amenorrhea. A physical examination revealed a woman with a feminine appearance characterized by long plaited hair and well-developed breasts. As part of the investigations to unravel the sex status, she had a resting standard 12-lead electrocardiogram which revealed a masculine electrocardiogram pattern with Ogunlade Sex Determination Electrocardiographic Score of 9 (T-wave pattern in lead V
1 , 3; ST segment in lead V2 or V3 , 3; QRS rotation, 2; heart rate of 79, 1). An abdominopelvic ultrasonography done by a radiologist showed absence of uterus, fallopian tubes, and ovaries. When our patient was considered for transvaginal scan, she declined but embraced translabial ultrasound as she claimed to be a virgin. Translabial ultrasonography revealed the presence of undescended hypoplastic testes with associated testicular microlithiasis at the external inguinal rings bilaterally. Karyotyping using a blood sample revealed 46,XY and a sex-determining region Y report showed that the blood sample was positive for the SRY gene confirming the status as male. This synchronized with the initial electrocardiogram evaluation. The testes were later removed., Conclusion: This report concluded that an electrocardiogram as a cheap, readily available and non-invasive test has a role in sex verification in young adults with primary amenorrhea.- Published
- 2018
- Full Text
- View/download PDF
9. Protective Effect of Kolaviron on Cyclophosphamide-Induced Cardiac Toxicity in Rats.
- Author
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Omole JG, Ayoka OA, Alabi QK, Adefisayo MA, Asafa MA, Olubunmi BO, and Fadeyi BA
- Subjects
- Animals, Cardiotoxicity etiology, Cardiotoxicity metabolism, Glutathione metabolism, Humans, Male, Malondialdehyde metabolism, Oxidative Stress drug effects, Rats, Rats, Wistar, Seeds chemistry, Superoxide Dismutase metabolism, Antineoplastic Agents, Alkylating adverse effects, Cardiotoxicity prevention & control, Cyclophosphamide adverse effects, Flavonoids administration & dosage, Garcinia kola chemistry, Plant Extracts administration & dosage, Protective Agents administration & dosage
- Abstract
Background: Cyclophosphamide (CP) is a nitrogen mustard alkylating drug used for the treatment of chronic and acute malignant lymphomas, myeloma, leukemia, neuroblastoma, adenocarcinoma, retinoblastoma, breast carcinoma, and immunosuppressive therapy. Despite its vast therapeutic uses, it is known to cause severe cardiac toxicity. Kolaviron (KV), a Garcinia kola seed extract containing a mixture of flavonoids, is reputed for its antioxidant and membrane stabilizing properties., Objective: This study investigated the protective effect of KV on CP-induced cardiotoxicity in rats., Methods: Thirty rats were used, and they were divided into 6 groups of 5 rats each. Group I received 2 mL/kg propylene glycol orally for 14 days; group II received CP (50 mg/kg/d, intraperitoneally [i.p.]) for 3 days; groups III and IV received 200 and 400 mg/kg/d KV, respectively, orally for 14 days and groups V and VI were pretreated with 200 and 400 mg/kg/d KV, respectively, orally for 14 days followed by CP (50 mg/kg/d, i.p.) for 3 days., Results: CP treatment resulted in a significantly lower food consumption and body weight in rats. The lactate dehydrogenase and creatine kinase enzymes in cardiac tissues of rats treated with CP were significantly higher. In cardiac tissues, 3-day doses of CP resulted in significantly higher heart weight, cardiac troponin I, myeloperoxidase, malondialdehyde, hydrogen peroxide and lower superoxide dismutase, catalase, glutathione peroxidase activities, and reduced glutathione levels. Histological examination of cardiac tissues showed sign of necrosis of myocardium after CP treatment. However, administration of KV at 200 and 400 mg/kg for 14 days prior to CP treatment, increase food consumption, body weight, and attenuates the biochemical and histological changes induced by CP., Conclusions: These results revealed that KV attenuates CP-induced cardiotoxicity by inhibiting oxidative stress and preserving the activity of antioxidant enzymes.
- Published
- 2018
- Full Text
- View/download PDF
10. The role of electrocardiogram in the diagnosis of dextrocardia with mirror image atrial arrangement and ventricular position in a young adult Nigerian in Ile-Ife: a case report.
- Author
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Ogunlade O, Ayoka AO, Akomolafe RO, Akinsomisoye OS, Irinoye AI, Ajao A, and Asafa MA
- Subjects
- Black People, Cardiomegaly diagnosis, Dextrocardia physiopathology, Diagnosis, Differential, Humans, Incidental Findings, Male, Nigeria, Situs Inversus physiopathology, Ultrasonography, Young Adult, Abdomen diagnostic imaging, Dextrocardia diagnosis, Electrocardiography, Situs Inversus diagnosis, Viscera diagnostic imaging
- Abstract
Introduction: Dextrocardia with situs inversus is a rare congenital disease. In patients with this condition, the heart is presented as a mirror image of itself with its apex pointing to the right. The pulmonary and abdominal anatomies are reversed. Dextrocardia with situs inversus occurs at birth but its diagnosis may be in adulthood. This case advances knowledge by graphically describing the unusual electrocardiographic features of dextrocardia in a young adult., Case Presentation: We report a case of a 22-year-old Nigerian man of Yoruba ethnicity who presented himself for preadmission medical test. He had a standard 12-lead electrocardiogram which revealed uncommon features: inversion of P waves in leads I, aVL and aVR; dominantly negative QRS waves in leads I, V1 to V6; reverse R wave progression in chest leads; low voltage in V4 to V6; extreme QRS axis; flattened T waves in V4 to V6 and aVR; and inverted T waves in lead I and aVL. An electrocardiogram diagnosis of dextrocardia was made. The differential diagnosis considered was right ventricular hypertrophy. A cardiovascular examination showed pulse rate of 70 beats per minute, blood pressure of 119/62mmHg, visible cardiac impulse at right precordium, apex beat was located at his fifth right intercostal space mid-clavicular line. A chest X-ray (posterior anterior view) including upper abdomen showed dextrocardia; his aortic arch was located on the right. His stomach bubble was located below his right hemidiaphragm. His trachea was slightly deviated to the left. The findings in his lung fields were not remarkable. Abdominopelvic ultrasonography showed that right-sided intra-abdominal organs (liver, gallbladder) were located on the left while left-sided organs (stomach, spleen) were located on the right. His abdominal aorta was on the right while his inferior vena cava was located on the left. A diagnosis of dextrocardia with situs inversus was made ultrasonographically., Conclusions: A properly interpreted electrocardiogram was useful in suspecting the diagnosis of dextrocardia with situs inversus. So, an analysis of a relatively simple and non-invasive diagnostic tool such as an electrocardiogram allows for suspicion of a cardiovascular anomaly in a setting of scarce diagnostic resources.
- Published
- 2015
- Full Text
- View/download PDF
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