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This article aims to apply the process of clinical governance to the management of patients with a major mental illness, living in the community, with a history of self harm and/or harm to others; and to design an early warning system to drive rapid intervention if patients miss a clinic appointment. This follows the recommendations of good clinical practice for this vulnerable group.

Thick calcrete profiles occur in the Late Devonian–early Carboniferous Kinnesswood Formation of the Midland Valley of Scotland. These profiles consist of highly brecciated peloidal and coated grain fabrics with laminar calcrete horizons and linings to fractures. The profiles resemble supermature calcretes associated with late Cenozoic surfaces in the southwestern United States and reflect pedogenesis over periods of several hundred thousand years or more. The possible origins of the highly complex fabrics seen are reviewed and the polygenetic nature of such profiles is stressed. It is suggested that brecciation takes place co-incident with subaerial exposure of the calcrete. Mature profiles may be predisposed to brecciation and surficial weathering because of their susceptibility to soil erosion as a result of changes in vegetation cover. The calcretes underwent phreatic cementation, burial dolomitization and silicification.

Background: There are few real life independent comparative studies of atypical antipsychotics. We prospectively examined five commonly used atypical antipychotics in the UK, without support from the pharmaceutical industry. Method: Prospective naturalistic systematic clinical evaluation. Patients being newly prescribed atypical anti-psychotics over a one year period were assessed by psychiatrists at initiation and after six months treatment using five outcome measures: clinical global impression; positive and negative psychotic symptoms; drug related side effects; and quality of life. Results: 373 patients participated in total. Olanzapine and risperidone produced statistically significant reductions in all ratings at stx months. Amisulpride, clozapine, and quetiapine were also studied. There was limited variance between the different drugs, although some sample sizes were small. Conclusion: Atypical anti-psychotics were found to be clinically effective, and produced similar outcomes. Routine monitoring of outcomes in psychiatry is feasible.

The research has spanned many topics at the boundary of particle physics and cosmology. The major focus has been in the general areas of inflationary cosmology, cosmological phase transitions, astrophysical constraints to particle physics theories, and dark matter/structure formation as it relates to particle physics. Some attention is given to axion physics. Narrative summaries of the research of the individual group members are given, followed by a list of publications.

Over the past year or so the research of our group has spanned many topics at the boundary of particle physics and cosmology. The major focus has been in the general areas of inflation, cosmological phase transitions, astrophysical constraints to particle physics theories, and dark matter/structure formation as it relates to particle physics. Narrative summaries of the research of the individual group members are given in this paper.

This report discusses inflationary cosmology; dark-matter detection; axions, astrophysics, and cosmology; topological defects; and astrophysical/cosmological constraints to particle properties. (LSP)

This article describes the application of linear programming to a problem faced by a small coal-mining company. The company owns two operating collieries, one supplies the general inland trade market while the other supplies a power station under a 30-year-tied contract. The company was awarded an export allocation for a 30-year period and as a result was trying to establish how to supply the coal for the various markets. Only the colliery that supplied the power station had sufficient reserves to base an export contract on. It was underlain by two economically recoverable seams of coal. The quality of the coal reserves is, however, low compared to international standards and is therefore unacceptable in its raw state. It is, however, possible to upgrade the coal by washing it. The grade of the final product (float) can be adjusted by altering the density of washing. However the yield, as a percentage of the raw coal feed, falls off rapidly as the grade is increased. Furthermore the sinks can likewise be upgraded by washing. The company wondered how they should optimize the flowsheet. How much coal should they mine from each of the two seams, how much from each source should go to the power station, how much should they produce for export, how should the upgrading be done, and to what extent. A linear programming model was formulated to solve the problem facing the company.

The actinomycin-D(AMD)-sensitive step of replication of three plant viruses - cowpea chlorotic mottle virus (CCMV), cowpea mosaic virus, and the cowpea strain of tobacco mosaic virus - in cowpea was specific for each virus. Different combinations of the viruses were examined in which leaves were inoculated with one virus and incubated for 48 h until multiplication was almost resistant to AMD. At that time, the same leaves were inoculated with a different virus and the ability of AMD to inhibit multiplication of the second virus was determined at intervals afterwards. In all combinations tested, the first virus had no effect on the sensitivity of the second virus to AMD. Also, resistance to AMD, which appeared to spread from cell to cell in advance of the virus in mechanically inoculated leaves, did not spread appreciably faster than CCMV into systemically infected upper leaves.