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The liver flukes Opisthorchis felineus, O. viverrini and Clonorchis sinensis are endemic in Russia, Southeast Asia and Far East where more than 18 million people are estimated to be infected. Opisthorchiasis remains the public health significance in Russia, and Western Siberia must be considered as highly endemic region for opisthorchiasis in the Russian Federation. High infection rates result from hazardous behaviours, centuries-old raw-food culture, a poor knowledge of opisthorchiasis, ecological complexities and complex biology. The infection is associated with several hepatobiliary diseases, including cholangiocarcinoma. Praziquantel is the only option for treatment of Opisthorchiasis . The detection the parasite’s eggs in stool still referred as gold standard. Recent research has provided new diagnostic technologies applicable to diagnosis, treatment and control. Despite some progress in their control, liver flukes continue to be a major public health problem in endemic areas.

In areas with high prevalence, intensity and incidence of soil-transmitted helminthosis four main soil-transmitted helminth infections, ascariasis, trichuriasis, strongyloidiasis and hookworm, are common clinical disorders in man. Mebendazole, albendazole, ivermectin and pyrantel are commonly used to remove these infections. The use of these drugs is not limited to treatment of symptomatic soil-transmitted helminth infections, but also for large-scale prevention of morbidity in children living in endemic areas. Recent research has provided new diagnostic technologies applicable to diagnosis, treatment and control. Despite some progress in their control, intestinal nematode infections continue to be a major public health problem in many regions.