1. Conductometric determination of trospium chloride by silver nitrate and phosphomolybidic acid
- Author
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E.M. Meselhy, Manal S. Elmasry, M.M. El Henawee, and A.A. Aboul Kheir
- Subjects
Conductometry ,Nortropanes ,Pharmaceutical Science ,Benzilates ,010402 general chemistry ,01 natural sciences ,chemistry.chemical_compound ,Molar ratio ,medicine ,Phosphoric Acids ,Molybdenum ,Pharmacology ,Trospium chloride ,010401 analytical chemistry ,Significant difference ,Reproducibility of Results ,0104 chemical sciences ,Silver nitrate ,chemistry ,Reagent ,Phosphomolybdic acid ,Silver Nitrate ,Indicators and Reagents ,Tablets ,Nuclear chemistry ,medicine.drug - Abstract
Two simple, accurate, sensitive and precise conductometric methods were developed for determination of trospium chloride in pure form and in pharmaceutical formulations. It is based on using two precipitating reagents; Phosphomolybdic acid (PMA) and Silver nitrate (AgNO3). The mean recovery for Silver nitrate is in the range (98-100.95%) and for Phosphomolybdic acid in the range (98-101.69%). A molar ratio has been determined conductometrically for the two reagents, revealed (1/1) for (drug/reagent). The proposed methods were validated and successfully applied for the determination of the studied drug in pure form and in its pharmaceutical preparation. The results of the proposed methods were compared to the results of reported method with no significant difference between them.
- Published
- 2020
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