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5 results on '"M.J. Holman"'

1. 2011 HM102: discovery of a high-inclination l5 Neptune trojan in the search for a post-pluto New Horizons target

Author

Parker M.W. Buie D.J. Osip S.D.J. Gwyn M.J. Holman D.M. Borncamp J.R. Spencer S.D. Benecchi R.P. Binzel F.E. Demeo S. Fabbro C.I. Fuentes P.L. Gay J.J. Kavelaars B.A. Mcleod J.M. Petit S.S. Sheppard S.A. Stern D.J. Tholen D.E. Trilling D.A. Ragozzine L.H., A.H., Univers, Transport, Interfaces, Nanostructures, Atmosphère et environnement, Molécules (UMR 6213) (UTINAM), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), and Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)

Subjects
ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2013

2. The Kuiper Belt Luminosity Function from mR = 21 to 26

Author

Fraser J.J. Kavelaars M.J. Holman C.J. Prichet B.J. Gladman T. Grav R.L. Jones J. Macwilliams J.-M. Petit, W.C., Institut Bisontin en Sciences Fondamentales (IBSF), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), and Debray, Bernard

Subjects
[PHYS.ASTR.CO]Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], [PHYS.ASTR.CO] Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2008

3. Oral Ganciclovir in the Prevention of Cytomegalovirus Infection in Postkidney Transplant 'CMV at Risk' Recipients: A Controlled, Comparative Study of Two Regimens (750 mg Bid and 500 mg Bid)

Author

M.J Holman, E Langhoff, Nasimul Ahsan, Harold C. Yang, and Lene Sonderbye

Subjects
Male, Human cytomegalovirus, Ganciclovir, medicine.medical_specialty, Administration, Oral, Pilot Projects, Antiviral Agents, Postoperative Complications, Risk Factors, Betaherpesvirinae, Internal medicine, medicine, Humans, Prospective Studies, Kidney transplantation, Transplantation, Dose-Response Relationship, Drug, biology, business.industry, Middle Aged, medicine.disease, biology.organism_classification, Kidney Transplantation, Clinical trial, Cytomegalovirus Infections, Immunology, Chemoprophylaxis, Kidney Failure, Chronic, Female, Surgery, Viral disease, business, Follow-Up Studies, medicine.drug
Published
1998
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4. The Kuiper Belt luminosity function from mR=22 to 25

Author

Petit M.J. Holman B.J. Gladman J.J. Kavelaars H. Scholl And T.J. Loredo., J.-M., Debray, Bernard, Laboratoire d'astrophysique de l'observatoire de Besançon (UMR 6091) (LAOB), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), and Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)

Subjects
[SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], [SDU.ASTR] Sciences of the Universe [physics]/Astrophysics [astro-ph]
Published
2006

5. CD40 regulates the processing of NF-kappaB2 p100 to p52

Author

Julia Janzen, Steven C. Ley, B. Huhse, Helen J. Coope, Monica P Belich, P.G.P. Atkinson, Leland H. Johnston, M.J. Holman, and G.G.B. Klaus

Subjects
Proteasome Endopeptidase Complex, genetic structures, Active Transport, Cell Nucleus, Protein Serine-Threonine Kinases, Ligands, Transfection, General Biochemistry, Genetics and Molecular Biology, Cell Line, Mice, NF-KappaB Inhibitor alpha, NF-kappa B p52 Subunit, Multienzyme Complexes, Proto-Oncogene Proteins, parasitic diseases, Protein biosynthesis, Transcriptional regulation, Animals, Humans, CD40 Antigens, Cycloheximide, Molecular Biology, Protein Synthesis Inhibitors, B-Lymphocytes, CD40, General Immunology and Microbiology, biology, Ubiquitin, General Neuroscience, HEK 293 cells, Transcription Factor RelB, NF-kappa B, NF-kappa B p50 Subunit, Articles, NFKB1, Molecular biology, Recombinant Proteins, DNA-Binding Proteins, IκBα, Cysteine Endopeptidases, biology.protein, I-kappa B Proteins, Protein Processing, Post-Translational, Transcription Factors
Abstract

The nf-kb2 gene encodes the cytoplasmic NF-kappaB inhibitory protein p100 from which the active p52 NF-kappaB subunit is derived by proteasome-mediated proteolysis. Ligands which stimulate p100 processing to p52 have not been defined. Here, ligation of CD40 on transfected 293 cells is shown to trigger p52 production by stimulating p100 ubiquitylation and subsequent proteasome-mediated proteolysis. CD40-mediated p52 accumulation is dependent on de novo protein synthesis and triggers p52 translocation into the nucleus to generate active NF-kappaB dimers. Endogenous CD40 ligation on primary murine splenic B cells also stimulates p100 processing, which results in the delayed nuclear translocation of p52-RelB dimers. In both 293 cells and primary splenic B cells, the ability of CD40 to trigger p100 processing requires functional NF-kappaB-inducing kinase (NIK). In contrast, NIK activity is not required for CD40 to stimulate the degradation of IkappaBalpha in either cell type. The regulation of p100 processing by CD40 is likely to be important for the transcriptional regulation of CD40 target genes in adaptive immune responses.

Published
2002

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