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1. Contents Vol. 64, 2003

Author

Steven J. O’Day, Emilia Crisanti, Massimo Di Maio, Peter K. Vogt, Manuela Pacyna-Gengelbach, Marija Gamulin, Giulio C. Spagnoli, Simona Messinese, S. Pyrhönen, Kurt Kletter, D.M. Katschinski, Tomotaka Kawayama, K.E. Rosenblatt, Tetsuya Yamamoto, Takashi Sugimura, R. Bendardaf, Chang Ok Suh, Keisuke Matsusaki, Takuji Okusaka, Y. Kishimoto, Daniele Turci, N. Malamos, Faraj Terro, Regina Deck, J. Laine, E. Karyda, Bert Hildebrandt, Takashi Fujishita, Genichi Nishimura, Cesare Gridelli, J. Tímár, Yuichi Oshita, K. Drumea, Ross E. Turner, W. Longo, Tsuyoshi Kimura, Rafael M. Nagler, Wataru Yasui, Tatsuhiko Kashii, Ofer Ben-Itzhak, Martha Hoffmann, Shuichi Okada, Hitoshi Tsuda, N. Haim, H. Lamlum, Monika Jermann, Koichi Shimizu, Hirofumi Nakayama, H. Kujari, Markus Raderer, Giuseppe D'Aiuto, Z. Orosz, H. Bailey, Sachio Fushida, Hejing Wang, M. Ben-Shachar, Anna Cappellini, Takashi Fukutomi, Ira Minkov, Jacques Hugon, Sandrine Robert, Frank Trimoreau, Johanna Skoglund, Yasuhiko Kitadai, Francesco Salvestrini, Maria Grazia Cantù, Shoko Oishi, Lars Meyer, Francesco Perrone, A. Kuten, Emanuela Rossi, Z. Voulgaris, Gunnar Arbman, Anna Emterling, Francesco Nuzzo, Peter D. Boasberg, Bernhard C. Pestalozzi, J. Hasegawa, R. Epelbaum, G. Shiota, Catherine Yardin, Michiya Matunami, Kazuaki Miyamoto, Kuniko Wakazono, John Carstensen, Tomislav Oresic, A. Ardavanis, Shoshana Ben-Eliezer, Hiroshi Funaki, Gerardo Amabile, Hedviga Kerner, Robert Šeparović, Luigi Terracciano, Alexander Becherer, Eleni Petridou, Y. Maeda, J. Finet, Hong Zhang, N. Miura, Takashi Tani, Massimo Loda, Toshimitsu Saisho, Antonio Juretić, W. Gillis, R. Ristamäki, K. Kalbakis, J.D.P. van Dijk, Hee Chul Park, M.E. Stein, Pierpaolo Correale, M Sabatino, Agnieszka Pietas, Roberto Petrioli, A.M. Westermann, S. Agelaki, Delia Marina Alexe, Michael Heberer, Daniele Pozzessere, Chigusa Morizane, Hisamichi Aizawa, A. Marumoto, Toshikazu Ushijima, Maurizio Marangolo, K. Malas, Oscar S. Breathnach, C.L. Tiggelaar, Antonio Rossi, Rumi Gohara, Takashi Fujimura, Naohide Oue, Itsuro Terada, Koichi Miwa, Gerardo Rosati, A. Bakhshandeh, Hiroshi Fukui, Yukiko Yagi, M. Gergye, Kiyoshi Asada, E. Jager, Kiyomi Taniyama, Masao Ichiki, Elke Schultz-Thater, Ulrich Jäger, Shunji Matsumura, Beth Tamar, Evagelos Spanos, Kyoo Ho Shin, Masato Kayahara, V. Georgoulias, Luigi Manzione, N. Udvarhelyi, Marinshine Gentler, P.Z. Vörde sive Vörding, Andreas Chott, Zbigniew Petrovich, Hideki Ueno, T. Bánfalvi, Diodoro Colarusso, Eric P. Winer, A. Knuth, Sofia Evertsson, J. Zidan, G. Landi, Yukihiro Tatemoto, Takeharu Koga, Ch. Kouroussis, Bozena Sarcevic, Eisaku Ueta, Iver Petersen, Zdenko Krajina, Y. Collan, Andrea de Matteis, Hong Ryull Pyo, V. Labonia, Y. Murawaki, François Labrousse, Hanno Riess, E. Gez, Panagiotis Koukoulomatis, S.O. Peters, Dimitrios Trichopoulos, Virginie Bellet, Teresa Di Palma, Tokio Osaki, Barbara Petit, A. Alexopoulos, T. Nakagawa, Ugo De Giorgi, Tomoko Kamimura, Jose Schneider, K. Gilde, Tim S. Kristedja, Isabelle Pommepuy, A. Neumann, Pat Ames, Tetsuo Ohta, Itasu Ninomiya, Susana M. Campos, G.J. Wiedemann, Guido Francini, Stefania Marsili, E. Tselepatiotis, Antonio Manganelli, Yuan Chen, Toru Rikimaru, Maureen Martin, D. Jager, Kelly Shinn, A. Sano, Bruce E. Johnson, Simone Petersen, H.I. Robins, Xiao-Feng Sun, and Shin-ichi Harada

Subjects
Cancer Research, Oncology, General Medicine
Published
2003
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2. Classical Kaposi’s Sarcoma in Caucasians in Africa – Experience at the Johannesburg Hospital (1978–1992)

Author

M.E. Stein, Werner R. Bezwoda, D. Spencer, and A. Kantor

Subjects
Adult, Male, medicine.medical_specialty, Skin Neoplasms, Treatment outcome, Dermatology, Hospitals, General, White People, South Africa, Remission induction, Humans, Medicine, Caucasian population, Sarcoma, Kaposi, Kaposi's sarcoma, Aged, Neoplasm Staging, Retrospective Studies, Aged, 80 and over, business.industry, Incidence, Incidence (epidemiology), Remission Induction, Follow up studies, Neoplasms, Second Primary, Middle Aged, medicine.disease, Surgery, Treatment Outcome, Female, Neoplasm staging, Sarcoma, business, Follow-Up Studies
Abstract

The data are scant concerning classical Kaposi's sarcoma (CKS) among the Caucasian population of Africa. A description of the clinical features of 15 such patients, treated and followed up at the Johannesburg General Hospital over a 14-year period (1978-1992) is presented. All patients were negative for the human immunodeficiency virus. After a mean follow-up of 50 months (range: 7-168 months), 2 patients are alive with absent or minimal disease; 1 patient is alive with stable disease and 1 has active disease involving his extremities. Three patients were lost to follow-up but had minimal or no disease when last seen. Five patients died of unrelated causes but also had minimal or no disease at their last visit. One patient died of sepsis related to active KS. Only two patients died of progressive KS. No alterations in humoral or cellular immunity were demonstrated in 2 patients with persistent disease. Four (27%) patients developed lymphoproliferative disorders including non-Hodgkin's lymphoma, Waldenström's macroglobulinemia, Hodgkin's disease and Castleman's disease (angiofollicular lymph node hyperplasia) preceding or following the diagnosis of CKS. These data confirm the indolent nature and good outcome of the classical form of Kaposi's sarcoma among Caucasians in the southern African region. The marked association between CKS and lymphoproliferative disorders warrants a long-term awareness and continued monitoring for these complications.

Published
1994
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3. Epidemic AIDS-related Kaposi's sarcoma in southern Africa: experience at the Johannesburg General Hospital (1980–1990)

Author

Werner R. Bezwoda, Paul Ruff, D. Spencer, A. Kantor, M.E. Stein, and N. Haim

Subjects
Adult, Male, Pediatrics, medicine.medical_specialty, Mucocutaneous zone, Disease Outbreaks, South Africa, Acquired immunodeficiency syndrome (AIDS), Immunopathology, Epidemiology, medicine, Humans, Sida, Sarcoma, Kaposi, Aged, Retrospective Studies, Acquired Immunodeficiency Syndrome, biology, business.industry, Palliative Care, Public Health, Environmental and Occupational Health, Retrospective cohort study, General Medicine, Middle Aged, medicine.disease, biology.organism_classification, Surgery, Treatment Outcome, Infectious Diseases, Female, Parasitology, Sarcoma, Viral disease, business
Abstract

Epidemic acquired immune deficiency syndrome-related Kaposi's sarcoma (AKS) in tropical and southern Africa is a highly varied neoplastic disease, characterized by multifocal mucocutaneous, lymphatic and visceral involvement. It follows a clinical course similar to AKS in Europe and the USA. However, lack of adequate medical facilities in many African countries hampers successful palliation of this fatal disease. In this retrospective analysis, we summarize our experience with 52 patients with AKS treated at Johannesburg General Hospital, South Africa, between 1980 and 1990. Radiation therapy can provide good to excellent palliation with only minimal side-effects, producing a lesser impact on the haematological and immunological system than chemotherapy.Researchers analyzed data on 52 HIV-positive patients with Kaposi's sarcoma (KS) aged 23-67 (74% Black, 26% White; male/female ratio = 2.8:1) referred to the Johannesburg General Hospital in South Africa during 1980-1990 to examine the hospital's experience with these patients. 23 patients had a fever and/or at least 10% weight loss. 34% had prior or coexistent opportunistic infection, particularly Pneumocystis carinii pneumonia, fungal disease, or tuberculosis. Possible risk factors among 21 patients were homosexual intercourse, history of sexually transmitted disease, and drug abuse. Almost all patients had skin disease, either localized or disseminated. Other KS sites included the oral cavity, regional lymph nodes, and large bowel. 90% of 20 patients treated with radiation responded to treatment. Response rates for radiation treatment among the 20 patients were 80% for symptomatic relief, 45% for complete remission, 45% for partial remission, and 10% for tumor progression. The recurrence-free period among irradiated patients was five months. Five patients developed radiation-induced mucositis of the oropharyngeal region. None of the 32 patients treated with chemotherapy and not radiation experienced complete remission. Chemotherapy induced partial remission in 38% and tumor progression in 62% of patients. 9% of chemotherapy-treated patients experienced symptomatic relief. Deteriorating performance status and/or debilitating side effects (severe mucositis and neutropenic sepsis) necessitated cessation of chemotherapy or dose modification. The clinical course of AIDS-related KS in this population paralleled that in Western countries. Based on these findings, the authors recommend local radiation therapy to treat AIDS-related KS or a watch-and-wait policy for asymptomatic, minimal disease in patients with an intact immune status.

Published
1994
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4. Primary small-cell carcinoma of the breast

Author

M.M. Quigley, Anthony Gershuny, L. Abdach, and M.E. Stein

Subjects
Oncology, medicine.medical_specialty, Primary (chemistry), Text mining, business.industry, Internal medicine, medicine, Radiology, Nuclear Medicine and imaging, medicine.disease, business, Small-cell carcinoma
Published
2005
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5. Subject Index Vol. 64, 2003

Author

Tomoko Kamimura, Peter D. Boasberg, Johanna Skoglund, Ira Minkov, Isabelle Pommepuy, W. Gillis, Francesco Salvestrini, S. Agelaki, J. Tímár, Eleni Petridou, Agnieszka Pietas, A. Bakhshandeh, Y. Maeda, Hirofumi Nakayama, Hong Zhang, Sandrine Robert, Takeharu Koga, Shoshana Ben-Eliezer, K. Kalbakis, Manuela Pacyna-Gengelbach, Ofer Ben-Itzhak, Marinshine Gentler, Anna Emterling, Peter K. Vogt, Shunji Matsumura, Luigi Manzione, Anna Cappellini, Hitoshi Tsuda, Tomislav Oresic, Robert Šeparović, G. Shiota, Tomotaka Kawayama, H. Kujari, Gunnar Arbman, Rafael M. Nagler, Wataru Yasui, Bernhard C. Pestalozzi, Marija Gamulin, Rumi Gohara, N. Miura, Tsuyoshi Kimura, Daniele Turci, François Labrousse, Jacques Hugon, D.M. Katschinski, H. Lamlum, Koichi Shimizu, Tatsuhiko Kashii, Hanno Riess, Takashi Sugimura, Massimo Loda, Ch. Kouroussis, A. Ardavanis, K. Drumea, J. Hasegawa, W. Longo, Michael Heberer, Ross E. Turner, N. Udvarhelyi, Jose Schneider, Sachio Fushida, Emanuela Rossi, Z. Voulgaris, A. Marumoto, Panagiotis Koukoulomatis, John Carstensen, E. Gez, H. Bailey, Maureen Martin, M.E. Stein, S.O. Peters, Naohide Oue, R. Bendardaf, K. Gilde, Iver Petersen, Zdenko Krajina, Hong Ryull Pyo, V. Labonia, Giulio C. Spagnoli, Francesco Nuzzo, Kuniko Wakazono, Hideki Ueno, Keisuke Matsusaki, Takuji Okusaka, Takashi Fukutomi, Kelly Shinn, Yasuhiko Kitadai, Simona Messinese, Beth Tamar, Chang Ok Suh, C.L. Tiggelaar, R. Epelbaum, Itsuro Terada, Kazuaki Miyamoto, Gerardo Amabile, R. Ristamäki, Diodoro Colarusso, Hisamichi Aizawa, Frank Trimoreau, H.I. Robins, Koichi Miwa, Gerardo Rosati, J. Laine, Faraj Terro, Eric P. Winer, Maria Grazia Cantù, Shoko Oishi, E. Karyda, A. Kuten, Takashi Fujishita, A. Knuth, E. Jager, N. Malamos, Sofia Evertsson, J. Zidan, Xiao-Feng Sun, Hiroshi Fukui, S. Pyrhönen, Evagelos Spanos, Shin-ichi Harada, Dimitrios Trichopoulos, Hedviga Kerner, Martha Hoffmann, Bert Hildebrandt, Regina Deck, Kyoo Ho Shin, V. Georgoulias, Hee Chul Park, Hiroshi Funaki, J. Finet, Toshimitsu Saisho, Steven J. O'Day, N. Haim, Monika Jermann, Yukihiro Tatemoto, Shuichi Okada, Delia Marina Alexe, T. Bánfalvi, Daniele Pozzessere, A.M. Westermann, Takashi Tani, Ulrich Jäger, Roberto Petrioli, Genichi Nishimura, G.J. Wiedemann, M. Ben-Shachar, Zbigniew Petrovich, Francesco Perrone, Yukiko Yagi, Susana M. Campos, Simone Petersen, Bruce E. Johnson, Yuichi Oshita, Kiyoshi Asada, A. Alexopoulos, Giuseppe D'Aiuto, Emilia Crisanti, Z. Orosz, Masato Kayahara, Antonio Manganelli, A. Neumann, Toshikazu Ushijima, Oscar S. Breathnach, Massimo Di Maio, Virginie Bellet, Y. Kishimoto, Cesare Gridelli, Teresa Di Palma, Luigi Terracciano, Tim S. Kristedja, Ugo De Giorgi, Tetsuya Yamamoto, P.Z. Vörde sive Vörding, Markus Raderer, M. Gergye, Lars Meyer, Tokio Osaki, Toru Rikimaru, Catherine Yardin, Alexander Becherer, G. Landi, Bozena Sarcevic, Itasu Ninomiya, D. Jager, Eisaku Ueta, Andrea de Matteis, Guido Francini, Stefania Marsili, E. Tselepatiotis, Chigusa Morizane, K.E. Rosenblatt, Kurt Kletter, Pierpaolo Correale, Pat Ames, Yuan Chen, A. Sano, T. Nakagawa, Michiya Matunami, Tetsuo Ohta, Antonio Rossi, Maurizio Marangolo, K. Malas, Antonio Juretić, M Sabatino, Takashi Fujimura, Kiyomi Taniyama, Masao Ichiki, Barbara Petit, Elke Schultz-Thater, Andreas Chott, J. D. P. Van Dijk, Hejing Wang, Y. Collan, and Y. Murawaki

Subjects
Cancer Research, Index (economics), Oncology, Statistics, Subject (documents), General Medicine, Mathematics
Published
2003
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7. Consolidation radiotherapy following cytoreductive surgery, chemotherapy and second-look laparotomy for epithelial ovarian carcinoma: Long-term follow-up

Author

E. Toffler, H. Goldberg, N. Menashe, M.E. Stein, Mariana Steiner, D. Beck, and Abraham Kuten

Subjects
Cancer Research, medicine.medical_specialty, Chemotherapy, business.industry, Long term follow up, General surgery, medicine.medical_treatment, Radiation therapy, Oncology, Epithelial ovarian carcinoma, Second look laparotomy, medicine, business, Cytoreductive surgery
Published
1999
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8. ‘Recumbent position’ and Stanford methods of total skin electron irradiation in the treatment of mycosis fungoides: comparison of long-term side effects

Author

Edward Rosenblatt, Abraham Kuten, M.E. Stein, R. Bar-Deroma, Martin Cederbaum, and E. Toffler

Subjects
Cancer Research, medicine.medical_specialty, Mycosis fungoides, Oncology, business.industry, Recumbent Position, medicine, Electron beam processing, medicine.disease, business, Dermatology
Published
1999
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