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2. POSTER VIEWING SESSION - REPRODUCTIVE ENDOCRINOLOGY

Author

L. Wildt, M. Alhalabi, C.B Lambalk, T. Cordes, G. Makrydimas, M. Turnovec, L. Mohiyiddeen, Y. Menezo, A. Ben Salem, B. Mannaerts, F. Carmona, M.C Magli, K.A.I. Xue, J. Higgs, M. Al Azemi, K. Toulis, C. Arrivi, P.G.A. Hompes, B. Wang, F.S Wu, A. Pellicer, C. Blockeel, N. Demir, P.M Bossuyt, J.S Yoon, H. Piao, E. Hatzi, E.M. van der Stroom, J. Moon, R.K.K. Lee, M. Poulasouhidou, W. Newman, C.A Venetis, A. Karkanaki, M. Vural, M. Dimitraki, R.D.S. Santos, J.E Han, W.K Kuchenbecker, C.Y Hur, K. Haller-Kikkatalo, Y.J Kang, Y. Cheong, M. Macek, N. Bayram, B. Tarlatzis, A. Chambers, R. Hiura, R. Formankova, K. Kishimoto, M. Manno, A. Nicoletti, I. Tamura, S. Modi, T.K Nilsson, R. Karayalcin, A. Volpes, F.C Massaro, M. Chronopoulou, M. Hellström, L.G Nardo, R. Gomez, A. Abousetta, M. Aboulghar, S.N Beemsterboer, M.H Lin, B. Coroleu, R. Homburg, M. Sterrenburg, A. Salazar, F. Cagampang, M. Camus, N. Shreeve, P. Devroey, S. Fernandes, S. Venturoli, S. Samawi, K.H Sadek, M. Sarafraz Yazdi, R.M Reis, K. Sfakianoudis, A. Watanabe, R. Takata, A. Pavlaki, R.E Bernardus, D. Dewailly, M. Aghahosseini, M. Sator, B. Gull, M. van Wely, Z. Zhou, L. Gianaroli, M.Y Won, V. Ventura, M. Youssef, Y.D Mao, H. Klucková, J. Vialard, M. Fernandez-Sanchez, J. Lee, N. Hatakeyama, R.A Ferriani, A. Chikawa, R. Nasiri, F. Fàbregues, C. Egarter, D. Bodri, B. Rashidi, F.M Helmerhorst, A. Overbeek, M. Snajderova, F. Lunger, S. Pang, T. Mousatat, B. Xu, L.F.I. Silva, P. Pemberton, P.L Broux, M. Touhami, G. Van Thillo, T. Yoon, M. Creus, R. Mendoza, J. Balasch, Y. Nafiye, B. Jee, E. Young, A. Teranisi, V. Gallot, A. Othman, H. Edalatkhah, F. Giolo, S. Banerjee, A.H Zarnani, E.A McGee, M.C Béné, M. van den Berg, X. Wang, S.W Lyu, Y. Oka, P.C.M. de Groot, L. Safdarian, K. Ozerkan, N. Celik, M. Laanpere, S.W.M. Dieben, S. Akira, L. Jungblut, F. Ramezanzadeh, E.M Kolibianakis, P. Scaglione, M. Dahan, A. Leader, I.O Song, W.G Newman, D. Nakayama, K. Iwahasi, S.N Kabir, M.C Pustovrh, C. Iaconelli, L. Yang, H. Zorgati, R. Matsuo, H.O Kim, L. van den Wijngaard, A. Sarapik, A.M.M. Cota, A. Demirol, I.S Kang, T. Kaart, J.H Yoo, N. Kafri, J.H Lim, R.L.R. Baruffi, M. Guimerà, E. Borges, L. Gao, L. Moy, S. Ozyer, H. Leonhardt, F.J Paula, G. Uncu, J.M Estanyol, S. Teramura, J.C Osborn, P. Merino, D. Kyrou, P. Keslova, D. Colleu, M. Ono, H. Mousavi Fatemi, N.P Polyzos, L.D Vagnini, F. van der Veen, J. Han, E. Chang, F. Diao, I. Afshan, P. Haentjens, C. Suh, D. Pietrowski, H. Won, S. Mehri, K. Doody, M. Franz, F.Y Diao, T. Waseda, S. Patchava, W.P Martins, E. Kintiraki, Z. Zhang, Y. Shibui, D. Gentien, M. Even, M.E.I. Li, S. Teramoto, C. González, C.A.M. Koks, D. Montjeant, S.A Roberts, N. Xita, M.J Nahuis, T. Mardesic, N. Koutlaki, A. Velthut, T. Hillensjo, Abdel-Gawad E Saad, M. Jo, Y. Hu, P. Paulasová, M. Ajina, P. Delagrange, J.A Romijn, K.L Radhika, K. Hatano, B. Prieto, I. Katsikis, S. Goswami, M. Dattilo, E. Stener-Victorin, I. Kasapoglu, O. Lao, Y. Kuwabara, G. Mintziori, N. Hope, I. Rodríguez, S. Lavery, K.C Kim, J. Stary, Y.V Louwers, F. Broekmans, V. Magnani, K. Isaka, G. Priou, D.H Barad, T. Fumino, S. Kahraman, M. Jinno, M. Kuwayama, C.N.M. Renckens, B.W.J. Mol, R. Paradisi, M. Farahpour, M. Kayser, N. Gleicher, C.I Messini, S. Altmäe, E. Codner, A. Marino, H. Sun, S.H Kim, Y.C Cheong, D. Athanatos, L. Szabo, J.J Guillén, R. Núñez, J.A Guijarro, M. de Carvalho, D. Stavrou, J. Smit, J.T Chung, W. van Dorp, A.M Ardekani, S.D Kim, J. Diblík, K. Mine, T. Iwasa, F.R Cagampang, F.H de Jong, N. Prados, N. Ohama, G. Pasquinelli, M.S Icen, Y. Uncu, F. Yazici, A. Smith, A. Allegra, H. Ben Ali, V. Loup, A. Guivarch Leveque, H. Witjes, M. Heidari, J.H Esler, H. Ferrero, B. Gurlek, K.A Toulis, D. Paz, N. Sugino, T. Abe, O. Valkenburg, H. Abdalla, A. Salumets, C. Ho, A. Weghofer, M.L Hendriks, N. Potdar, H. Toy, T.A Gelbaya, H. Al-Inany, S. Assou, R. Santana, K. Niyani, A. Pane, R. Fabbri, C.G Petersen, A. Piouka, W.S Lee, Y. Kim, V. Basconi, G. Yan, I. Georgiou, Z. Qiu, J.H Jung, F. Massin, K. Kotaska, H.M Fatemi, R. Uibo, B.C Tarlatzis, N. Kose, R. Matorras, X. Hu, H. Asada, W. Lee, J.S.E. Laven, A. Khatib, S. Sharma, H. McBurney, I. Schipper, S.H Yang, M. Kazuka, R. Schats, K. Dafopoulos, S. Daube, H. Tournaye, B.C Jee, G. Ruvolo, T.G Tzellos, K. Pantos, C. Motteram, J. Cerníková, L.J Rombauts, H. Rahmanpour Zanjani, G. Giakoumakis, S. Lin, M. Hrehorcák, G. Daskalopoulos, F.E. van Leeuwen, J. Choi, S. Talebi, Y.U.A.N. Zhang, B. Seeber, S.D Sharma, R. Fujii, A. Katayama, A. Yaba, S. Engels, A. Schultze-Mosgau, E. Lee, S. Kim, S. Ono, F. Davari, O. Coll, A. Just, C. Battaglia, K. Gordon, J. Sha, E. Angeli, C. Villarroel, J.B.A. Oliveira, T. Ichikawa, H.J.H.M. van Dessel, O. Iannetta, F.M Valente, F. Delgado, S. Batioglu, Y. Cui, H. Tomizawa, R. Baydoun, W.D Lee, S. Soliman, T. Sasagawa, T. Okubo, A. Taha, W. Ding, W. Wang, S. Dória, P. Arvis, M.L Tartaglia, A.P Ferraretti, S. Lie Fong, S. Reinblatt, K.S Lim, E. Hasegawa, S. Fujita, M.A Akhtar, M. Baghrei, D. Delkos, S. Roberts, J. Ramos Vidal, I. Kwak, Y.J Kim, D. Beyer, F. Aspichueta, M. Trullenque, J.B.F. Fernandes, S. Usuda, M. Colakoglu, H. Dechaud, E.J Oude Loohuis, T. Gurgan, O.M Dekkers, J. García, R. Iannetta, C. Keck, M. Shigeta, H. Tamura, J. Liu, K.H Kim, T. Takeshita, S.A Mouratoglou, G.J.E. Oosterhuis, M. Macciocca, J. Sharif, M. Demirtas, J.Y Liu, C. Simon, A. Iraola, C. Vieira, L. Nardo, A. Exposito, T. Stefos, K. Zikopoulos, M. De Vos, K. Diedrich, L. Lazaros, R. Fanchin, K.B Bruce, P. Feldmár, P. Hompes, P. Chakraborty, S. Makinoda, M. Abuzeid, C.M Hill, J.G Franco, M. Benkhalifa, V. Vernaeve, M.K Koong, T.K Yoon, H. Rahmanpour, A. Stavreus-Evers, D. Panidis, L.G Maldonado, T.B Tarlatzi, J.W Kim, S.K Goswami, A. Pontes, H. Seok, R. Cartwright, C. Cordeo, J. Cho, S. Stergianos, N. Kim, J. Nicopoullos, G.C Faure, S. Van Voorst, T. Yeko, S.H Shim, J. Alonso, J.M. van Montfrans, W.Y Son, D.P.A.F. Braga, E.G Papanikolaou, B.N Chakravarty, K.A Park, M.W Heymans, K. Kim, A. Yates, C.E Martinelli, K. Navaratnam, T.E König, F. Sarvi, A. Iaconelli, M.C Fasolino, A. Barros, G. Trew, I. Kale, P.N Barri, R. Frydman, J. Wolyncevic, R. Tomiyama, P. Caballero, J. Bosdou, G. Casals, F. Lamazou, G. Griesinger, E. Eukarpidis, D. Ankers, E. van Dulmen-den Broeder, S.S Nandi, N. Buendgen, G.M Soares, L. Fien, H. Ito, A. Rodríguez, D. Tsolakidis, H. Billi, A.C.J.S. Rosa e Silva, A. Sarkar, L. Crisol, Y.M Hwu, A.G Uitterlinden, D. Lee, A. Gonzalez-Ravina, M. Kataoka, G. Lockwood, G. Ding, I. Parazza, A.L Mauri, C. Caligara, H. Takagi, M. Cavagna, B. Ata, L. Homer, R. Tur, A. Tocino, N. Neyatani, K. Sadek, M.H Mochtar, H. Hamai, T. Taketani, M.F Silva de Sá, A. Kaponis, M. Kavrut, D.G Goulis, J. Van Leeuwen, N. Brook, R. Chattopadhyay, G. Pados, T. Vaxevanoglou, S. Ghosh, S. Hamamah, T. Anahory, L.E.E. van der Houwen, X. Ma, B. Mulugeta, P. Sedlacek, H. Holzer, N.M. van Mello, O. Rustamov, N. Macklon, M. Devesa, J. Hirohama, I.E Messinis, A. García, S.H Cha, A. Aleyasin, S. Cortés, S.J Chae, D. Choi, M. Grynberg, F.J Carranza, A.S Mahmoud, N. Sofikitis, T. Gioka, J. Elbers, W. Dietrich, F. Gaytan, T.P Lima, P. López, G. Iñiguez, and A.S Setti

Subjects
medicine.medical_specialty, Reproductive Medicine, Family medicine, Rehabilitation, medicine, Reproductive Endocrinology, Obstetrics and Gynecology, Session (computer science)
Published
2011
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11. Most humoral non-responders to hepatitis B vaccines develop HBV-specific cellular immune responses

Author

M.C Béné, Patricia Aguilar, M.L Lepori, M.C Vignaud, M.N Kolopp-Sarda, G.C Faure, L Jarrosson, and C Kohler

Subjects
Adult, Male, Cellular immunity, Genotype, Health Personnel, T-Lymphocytes, CD4-CD8 Ratio, Immunization, Secondary, medicine.disease_cause, Th2 Cells, Immune system, Antigen, Orthohepadnavirus, Occupational Exposure, Humans, Medicine, Hepatitis B Vaccines, Lymphocytes, Hepatitis B virus, Immunity, Cellular, Hepatitis B Surface Antigens, Polymorphism, Genetic, General Veterinary, General Immunology and Microbiology, biology, business.industry, Public Health, Environmental and Occupational Health, Middle Aged, Th1 Cells, Hepatitis B, biology.organism_classification, medicine.disease, Virology, Phenotype, Infectious Diseases, Hepadnaviridae, Antibody Formation, Immunology, Humoral immunity, Cytokines, Molecular Medicine, Female, business, Cell Division
Abstract

About 10% of health care professionals vaccinated against hepatitis B virus (HBV) fail to develop protective antibodies. We tested the capacity of peripheral blood lymphocytes from 121 health care professionals, including 76 non-responders, to proliferate to four HBV vaccines, examined the proliferating cells' subset, production of IFN-gamma, IL-4 and IL-10, and for 22 subjects, the cytokine production genotype. Specific proliferative responses to at least one HBV antigen were noted in 75% humoral non-responders. These cells differed from the CD4+ strongly proliferating cells of responders. Non-responders frequently displayed a genotype of high TGF-beta and intermediate IL-10 secretion. Most humoral non-responders to HBV thus develop specific cellular immune responses, eventually liable to protect them against viral infection.

Published
2004
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12. Contents, Vol. 47, 1997

Author

P. Chanson, X. Jeunemaitre, M. Talbot, D. Simpson, Emmanuel Gautherot, Annick Martin, Maria Luisa Brandi, Jp. Aubert, Catharina Larsson, F. Mantero, Cx. Zhang, David Wynford-Thomas, Claude Jaffiol, M. Boggild, Simona Mantovani, A.M. Masini, Eric Clauser, A. Angeli, Véronique Alvaro, Cristina Missale, G. Gunz, B. Fournes, A. Enjalbert, Olov Nilsson, I. Morange-Ramos, Charis Eng, B. Conte-Devolx, A. Courseaux, Eric Rouvier, A. Murat, Lars-Ove Farnebo, Alessandra Finardi, Filip Farnebo, G. Cadiot, P. Niccoli, B. Allolio, C. Beldjord, Massimo Giovanelli, Colette Auzan, P. Jaquet, P. Gaudray, Corinne Prévostel, Chiara Fiorentini, A. Ali, M. Giovagnetti, Pascal Meyer, R. Monier, B. Maes, Marco Losa, M. Terzolo, V. Aubert, Xavier Bertagna, Sandra Sigala, J.F. Hewy, W. Farrell, G. Arnaldi, M. Klein, A. Calender, J. Leclère, Jérôme Bertherat, Frederic Lenne, G. Osella, Patricia René, J. Bicknell, Andrea Lania, N. Porchet, Pf. Plouin, C. Gicquel, M.C. Béné, A. Barlier, Lois M. Mulligan, A. Boneu, L. Caccavelli, B. Caillou, Anna Spada, P. Rochefort, G. Opocher, G. Faure, Jacques Barbel, S. Giraud, Deborah J. Marsh, F. Michiels, Johannes Järhult, P. Rodien, Jacob Lagercrantz, Bin Tean Teh, J. Feunteun, G. Weryha, Dominique Joubert, M. Reincke, I. Schuffenecker, J.B. Corcuff, L. Mercken, Kerstin Sandelin, C. Dumont, M. Schlumberger, Y. Le Bouc, E. Modigliani, Yves de Keyzer, V. Pascal-Vigneron, Emilia Ballaré, Günther Weber, A.S. Bates, R.N. Clayton, I. Pellegrini-Bouiller, PierFranco Spano, N. Barbot, and Gm. Lenoir

Subjects
Endocrinology, Endocrinology, Diabetes and Metabolism
Published
1997
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13. Bilan immunologique d’une maladie abortive : quels examens demander ?

Author

M.C. Béné, P Barbarino-Monnier, and Gilbert C. Faure

Subjects
Gynecology, medicine.medical_specialty, Pregnancy, business.industry, Obstetrics and Gynecology, General Medicine, Abortion, medicine.disease_cause, medicine.disease, Auto immunite, Autoimmunity, Recurrent Abortions, First trimester, Clinical research, Reproductive Medicine, Immunology, medicine, business
Abstract

Recurrent unexplained abortions are defined as at least two successive abortions during the first trimester of pregnancy. Implication of autoimmunity processes is now widely recognized. The list of biological assays proposed in recurrent abortions is inspired from immunological exploration of systemic lupus erythematosus in which pregnancy usually induces high risk for the conception product. Other assays derive from immunological hypotheses explaining the tolerance paradox of pregnancy, but many have not yet been established and will still require clinical research protocols.

Published
2003
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14. Anti-ovary antibodies after attempts at human in vitro fertilization induced by follicular puncture rather than hormonal stimulation

Author

G.C. Faure, P. Barbarino-Monnier, B. Gobert, M.C. Béné, and F. Guillet-May

Subjects
Ovulation, Embryology, medicine.medical_specialty, Menotropins, medicine.medical_treatment, Enzyme-Linked Immunosorbent Assay, Stimulation, Ovary, Fertilization in Vitro, Punctures, Biology, Endocrinology, Ovarian Follicle, Internal medicine, Follicular phase, medicine, Humans, Autoantibodies, Pregnancy, In vitro fertilisation, Obstetrics and Gynecology, Cell Biology, Oocyte, medicine.disease, medicine.anatomical_structure, Immunoglobulin M, Reproductive Medicine, Immunoglobulin G, Oocytes, Female, Hormone
Abstract

Anti-ovary antibodies (AOA) have been detected in serum samples of women undergoing in vitro fertilization (IVF). High concentrations of these antibodies have been found in women who have had several IVF attempts and they appear to correlate with reduced chances of pregnancy. In this paper, AOA were assayed sequentially in a series of 140 IVF candidates to investigate the respective roles of hormonal stimulation and follicular puncture in inducing the autoimmune response. Serum was obtained 8 days after the beginning of ovarian human menopausal gonadotrophin (hMG) stimulation, then 15 days after follicular puncture. Significantly higher concentrations of IgG (P < 0.0001) AOA were observed in the second series of samples than in the first, suggesting that ovarian trauma and not hormonal stimulation is responsible for triggering antibody production. In the whole group, there was a negative correlation between IgM levels after puncture and oocyte numbers (P < 0.05). Among 'immune-responder' women, the concentrations of IgA AOA (P = 0.01) in the first sample, and of IgG (P = 0.01) or IgA AOA (P < 0.05) in the second, correlated with fewer oocytes after stimulation. There was no variation in the mean concentrations of AOA in women who achieved pregnancy.

Published
1992
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17. 66 Hypersensibilité semi retardée aux protéines du lait de vache à révélation néonatale : à propos d’un cas par un mécanisme d’hypersensibilité type iii selon gell et coombs

Author

S. Al Hawari, M.C. Béné, A. Hamdo, Marie-Nathalie Kolopp-Sarda, L. Léké, T. Aboudiab, and J.P. Chouraki

Subjects
Reproductive Medicine, Obstetrics and Gynecology, General Medicine
Abstract

Journal de Gynecologie Obstetrique et Biologie de la Reproduction - Vol. 33 - N° 4 - p. 365-366

Published
2004
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18. Ovarian autoimmunity and corticotherapy in an in-vitro fertilization attempt

Author

F. Guillet-May, M.C. Béné, P. Barbarino-Monnier, G.C. Faure, B. Gobert, B. Foliguet, and A. Barbarino

Subjects
Adult, endocrine system, medicine.medical_specialty, media_common.quotation_subject, medicine.medical_treatment, Prednisolone, Immunoglobulins, Ovary, Fertilization in Vitro, Biology, Insemination, Human fertilization, Pregnancy, medicine, Humans, Ovulation, reproductive and urinary physiology, media_common, Autoantibodies, Gynecology, In vitro fertilisation, Rehabilitation, Pregnancy Outcome, Obstetrics and Gynecology, female genital diseases and pregnancy complications, Regimen, medicine.anatomical_structure, Treatment Outcome, Reproductive Medicine, Female, Menotropins, medicine.drug
Abstract

This case report describes a successful pregnancy and delivery in a woman presenting with ovarian autoimmunity who had previously been involved in two unsuccessful in-vitro fertilization (IVF) attempts. Ten days before a third attempt, she began a regimen of 25 mg per day of prednisolone which was continued throughout the whole IVF protocol. Ovulation was induced by human menopausal gonadotrophin. After administration of 5000 IU of human chorionic gonadotrophin, 18 oocytes were collected. At 48 h after insemination with the patient's husband's spermatozoa, four 4-cell pre-embryos were transferred. A singleton pregnancy developed and led to the birth of a girl who is doing well 10 months later.

Published
1995

22. Prevalence, Specificity and Significance of Ovarian Antibodies During Spontaneous Premature Ovarian Failure

Author

Sylvie Hiéronimus, B. Gobert, Patrick Fénichel, M.C. Béné, Michel Harter, P. Barbarino-Monnier, and C. Sosset

Subjects
Adult, Male, medicine.medical_specialty, Anti-nuclear antibody, Graves' disease, HLA-DR3, Ovary, Primary Ovarian Insufficiency, Gastroenterology, Autoimmune Diseases, Antibody Specificity, Pregnancy, Thyroid peroxidase, Internal medicine, Biopsy, medicine, Humans, Amenorrhea, Autoantibodies, Autoimmune disease, Gynecology, medicine.diagnostic_test, biology, business.industry, Rehabilitation, Estrogen Replacement Therapy, Thyroid, Autoantibody, Obstetrics and Gynecology, HLA-DR Antigens, General Medicine, Middle Aged, medicine.disease, Immunoglobulin A, Premature ovarian failure, Endocrinology, medicine.anatomical_structure, Reproductive Medicine, Immunoglobulin M, Immunoglobulin G, biology.protein, Female, Antibody, business
Abstract

Autoimmunity may be involved in idiopathic premature ovarian failure (POF). However, the frequency, physiopathology and potential reversibility of autoimmune oophoritis needs clarification. Using an ELISA against whole tissue homogenate as antigen, from human ovaries at different ages, positive circulating ovarian antibodies (AOA) were found in 59% of patients with primitive idiopathic POF (27/46); 20/27 were positive for IgG isotype, 9/27 for IgM and 8/27 for IgA. Specificity of AOA was examined (i) by comparison to different control groups; mean values of the three subclasses of immunoglobins were significantly higher in POF women than in normally cycling fertile young women (n = 23) and fertile young men (n = 17), in untreated Grave's disease (n = 35) or in women with positive antinuclear factor (n = 25); and (ii) by assessing possible cross-reaction; only six out of the 27 positive sera reacted with other tissues (thyroid, pancreas, adrenal), including four clinical polyendocrinopathies. Significance of AOA was explored (i) by comparison with postmenopausal women (n = 40) and older women (n = 15), who did not have enhanced ratios of AOA, thereby excluding a potential role of high FSH values; (ii) by analysing the factors time and surgery; no relation could be found either with the duration of amenorrhoea (6 months to 21 years) or with the history of an ovarian biopsy (12/47) in the absence of any associated pelvic surgery; and (iii) by screening for other immunological factors; familial or personal autoimmune disease (8/46), HLA DR3 (10/42), HLA DR4 (11/42), associated autoantibodies (thyroperoxidase, adrenal, beta islets, parathyroid, DNA, smooth muscles) (12/42). If one positive AOA isotype was present, a second immunological factor was found in 45% of cases. Spontaneous pregnancies during oestrogen therapy occurred in four cases, including three women with positive AOA. Circulating AOA detected by an ELISA may represent a practical and suitable marker for diagnosis of POF. Its use for prognosis and rational treatment needs further evaluation.

Published
1998
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24. Subject Index Vol. 47, 1997

Author

C. Beldjord, Colette Auzan, Pf. Plouin, Chiara Fiorentini, Charis Eng, A.M. Masini, A. Boneu, G. Faure, Claude Jaffiol, M. Boggild, Deborah J. Marsh, F. Michiels, S. Giraud, Simona Mantovani, Eric Clauser, A.S. Bates, Yves de Keyzer, P. Gaudray, V. Pascal-Vigneron, Jacques Barbel, J. Feunteun, I. Morange-Ramos, A. Angeli, Andrea Lania, Emilia Ballaré, M. Reincke, Corinne Prévostel, PierFranco Spano, N. Barbot, Dominique Joubert, I. Schuffenecker, N. Porchet, V. Aubert, Xavier Bertagna, R. Monier, B. Maes, Jacob Lagercrantz, M.C. Béné, M. Giovagnetti, Marco Losa, Lois M. Mulligan, Bin Tean Teh, G. Gunz, M. Terzolo, A. Enjalbert, A. Courseaux, Johannes Järhult, Y. Le Bouc, M. Klein, Emmanuel Gautherot, F. Mantero, Lars-Ove Farnebo, B. Fournes, Günther Weber, E. Modigliani, Catharina Larsson, Jérôme Bertherat, B. Caillou, Sandra Sigala, Véronique Alvaro, W. Farrell, Jp. Aubert, A. Calender, Cx. Zhang, Gm. Lenoir, G. Osella, Anna Spada, A. Murat, J.B. Corcuff, C. Gicquel, L. Caccavelli, G. Opocher, A. Martin, P. Rochefort, Massimo Giovanelli, B. Conte-Devolx, Cristina Missale, Pascal Meyer, Alessandra Finardi, Filip Farnebo, J. Leclère, P. Niccoli, J. Bicknell, B. Allolio, J.F. Hewy, P. Jaquet, Patricia René, A. Ali, A. Barlier, R.N. Clayton, I. Pellegrini-Bouiller, Maria Luisa Brandi, David Wynford-Thomas, Olov Nilsson, C. Dumont, M. Schlumberger, G. Arnaldi, L. Mercken, Kerstin Sandelin, P. Chanson, X. Jeunemaitre, M. Talbot, D. Simpson, P. Rodien, Frederic Lenne, G. Weryha, Eric Rouvier, and G. Cadiot

Subjects
Endocrinology, Index (economics), Endocrinology, Diabetes and Metabolism, Statistics, Subject (documents), Mathematics
Published
1997
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28. Autoimmunity and antigenic targets in ovarian pathology.

Author

T. Forges, P. Monnier‐Barbarino, G.C. Faure, and M.C. Béné

Abstract

The involvement of autoimmune mechanisms in premature ovarian failure has been put forward by numerous investigators. In various other ovarian pathologies, such as idiopathic infertility, polycystic ovary syndrome, or endometriosis, similar mechanisms have been suggested. However, the exact role of autoimmunity in the pathophysiology of these diseases still remains controversial. The diagnosis of autoimmune ovarian disease relies on several clinical, biological and histological findings, but special interest has been focused on antiovarian autoantibodies. The search for these antibodies has been undertaken by several authors and yielded somewhat conflicting results which might be conditioned by methodological differences and by the multiplicity of potential immune targets. These targets, which comprise various steroidogenic enzymes, gonadotrophins and their receptors, the corpus luteum, zona pellucida and oocyte, are reviewed. Further investigation of these targets is required to improve the diagnostic tools that will lead to a precocious and reliable diagnosis of autoimmune ovarian disease, an appropriate clinical surveillance as well as the selection of patients who may benefit from immune‐modulating therapy and possibly recover ovarian function and fertility. [ABSTRACT FROM AUTHOR]

Published
2004
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