15 results on '"M.-L. Yaspo"'
Search Results
2. 1142P Treatment of metastatic uveal melanoma (mUM) through genomic profiling
- Author
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I. Jelas, Antonia M. Joussen, Vyacheslav Amstislavskiy, C.A. Peuker, Frederick Klauschen, Thomas Kessler, B. Lange, M-L. Yaspo, Moritz Schütte, Serge Leyvraz, Susen Burock, Thomas Risch, G. Dörpholz, Mario Lamping, Christoph Wierling, Sebastian Ochsenreither, Claas Ulrich, Damian T. Rieke, U. Keilholz, and R. Schäfer
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Genomic profiling ,Oncology ,business.industry ,Melanoma ,Cancer research ,medicine ,Hematology ,medicine.disease ,business - Published
- 2020
3. MEDULLOBLASTOMA
- Author
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G. Vaidyanathan, S. Gururangan, D. Bigner, M. Zalutsky, M. Morfouace, A. Shelat, J. Megan, B. B. Freeman, S. Robinson, S. Throm, J. M. Olson, X.-N. Li, K. R. Guy, G. Robinson, C. Stewart, A. Gajjar, M. Roussel, N. Sirachainan, S. Pakakasama, U. Anurathapan, A. Hansasuta, M. Dhanachai, C. Khongkhatithum, S. Hongeng, A. Feroze, K.-S. Lee, S. Gholamin, Z. Wu, B. Lu, S. Mitra, S. Cheshier, P. Northcott, C. Lee, T. Zichner, P. Lichter, J. Korbel, R. Wechsler-Reya, S. Pfister, I. P. T. Project, K. K.-W. Li, T. Xia, F. M. T. Ma, R. Zhang, L. Zhou, K.-M. Lau, H.-K. Ng, L. Lafay-Cousin, S. Chi, J. Madden, A. Smith, E. Wells, E. Owens, D. Strother, N. Foreman, R. Packer, E. Bouffet, T. Wataya, J. Peacock, M. D. Taylor, D. Ivanov, M. Garnett, T. Parker, C. Alexander, L. Meijer, R. Grundy, P. Gellert, M. Ashford, D. Walker, J. Brent, F. Z. Cader, D. Ford, A. Kay, R. Walsh, G. Solanki, A. Peet, M. English, T. Shalaby, G. Fiaschetti, S. Baulande, N. Gerber, M. Baumgartner, M. Grotzer, T. Hayase, Y. Kawahara, M. Yagi, T. Minami, N. Kanai, T. Yamaguchi, A. Gomi, A. Morimoto, R. Hill, S. Kuijper, J. Lindsey, E. Schwalbe, K. Barker, J. Boult, D. Williamson, Z. Ahmad, A. Hallsworth, S. Ryan, E. Poon, R. Ruddle, F. Raynaud, L. Howell, C. Kwok, A. Joshi, S. L. Nicholson, S. Crosier, S. Wharton, K. Robson, A. Michalski, D. Hargrave, T. Jacques, B. Pizer, S. Bailey, F. Swartling, K. Petrie, W. Weiss, L. Chesler, S. Clifford, L. Kitanovski, T. Prelog, B. F. Kotnik, M. Debeljak, M. A. Grotzer, A. Gevorgian, E. Morozova, I. Kazantsev, T. Iukhta, S. Safonova, E. Kumirova, Y. Punanov, B. Afanasyev, O. Zheludkova, W. Grajkowska, M. Pronicki, B. Cukrowska, B. Dembowska-Baginska, M. Lastowska, A. Murase, S. Nobusawa, Y. Gemma, F. Yamazaki, A. Masuzawa, T. Uno, T. Osumi, Y. Shioda, C. Kiyotani, T. Mori, K. Matsumoto, H. Ogiwara, N. Morota, J. Hirato, A. Nakazawa, K. Terashima, T. Fay-McClymont, K. Walsh, D. Mabbott, D. Sturm, P. A. Northcott, D. T. W. Jones, A. Korshunov, S. M. Pfister, M. Kool, C. Hooper, S. Hawes, U. Kees, N. Gottardo, P. Dallas, A. Siegfried, A. I. Bertozzi, A. Sevely, N. Loukh, C. Munzer, C. Miquel, F. Bourdeaut, T. Pietsch, C. Dufour, M. B. Delisle, D. Kawauchi, J. Rehg, D. Finkelstein, F. Zindy, T. Phoenix, R. Gilbertson, J. Trubicka, M. Borucka-Mankiewicz, E. Ciara, K. Chrzanowska, M. Perek-Polnik, D. Abramczuk-Piekutowska, D. Jurkiewicz, S. Luczak, P. Kowalski, M. Krajewska-Walasek, C. Sheila, S. Lee, C. Foster, B. Manoranjan, M. Pambit, R. Berns, A. Fotovati, C. Venugopal, K. O'Halloran, A. Narendran, C. Hawkins, V. Ramaswamy, M. Taylor, A. Singhal, J. Hukin, R. Rassekh, S. Yip, S. Singh, C. Duhman, S. Dunn, T. Chen, S. Rush, H. Fuji, Y. Ishida, T. Onoe, T. Kanda, Y. Kase, H. Yamashita, S. Murayama, Y. Nakasu, T. Kurimoto, A. Kondo, S. Sakaguchi, J. Fujimura, M. Saito, T. Arakawa, H. Arai, T. Shimizu, E. Jurkiewicz, P. Daszkiewicz, M. Drogosiewicz, V. Hovestadt, I. Buchhalter, N. N. Jager, A. Stuetz, P. Johann, C. Schmidt, M. Ryzhova, P. Landgraf, M. Hasselblatt, U. Schuller, M.-L. Yaspo, A. von Deimling, R. Eils, A. Modi, M. Patel, M. Berk, L.-x. Wang, G. Plautz, H. Camara-Costa, A. Resch, C. Lalande, V. Kieffer, G. Poggi, C. Kennedy, K. Bull, G. Calaminus, J. Grill, F. Doz, S. Rutkowski, M. Massimino, R.-D. Kortmann, B. Lannering, G. Dellatolas, M. Chevignard, D. Solecki, P. McKinnon, J. Olson, J. Hayden, D. Ellison, M. Buss, M. Remke, J. Lee, T. Caspary, R. Castellino, M. Sabel, G. Gustafsson, G. Fleischhack, M. Benesch, A. Navajas, R. Reddingius, M.-B. Delisle, D. Lafon, N. Sevenet, G. Pierron, O. Delattre, J. Ecker, I. Oehme, R. Mazitschek, M. Lodrini, H. E. Deubzer, A. E. Kulozik, O. Witt, T. Milde, D. Patmore, N. Boulos, K. Wright, S. Boop, T. Janicki, S. Burzynski, G. Burzynski, A. Marszalek, J. Triscott, M. Green, S. R. Rassekh, B. Toyota, C. Dunham, S. E. Dunn, K.-W. Liu, Y. Pei, L. Genovesi, P. Ji, M. Davis, C. G. Ng, Y.-J. Cho, N. Jenkins, N. Copeland, B. Wainwright, Y. Tang, S. Schubert, B. Nguyen, S. Masoud, A. Lee, M. Willardson, P. Bandopadhayay, G. Bergthold, S. Atwood, R. Whitson, J. Qi, R. Beroukhim, J. Tang, A. Oro, B. Link, J. Bradner, S. G. Vallero, D. Bertin, M. E. Basso, C. Milanaccio, P. Peretta, A. Cama, A. Mussano, S. Barra, G. Morana, I. Morra, P. Nozza, F. Fagioli, M. L. Garre, A. Darabi, E. Sanden, E. Visse, N. Stahl, P. Siesjo, D. Vaka, F. Vasquez, B. Weir, G. Cowley, C. Keller, W. Hahn, I. C. Gibbs, S. Partap, K. Yeom, M. Martinez, H. Vogel, S. S. Donaldson, P. Fisher, S. Perreault, L. Guerrini-Rousseau, S. Pujet, V. Kieffer-Renaux, M. A. Raquin, P. Varlet, A. Longaud, C. Sainte-Rose, D. Valteau-Couanet, J. Staal, L. S. Lau, H. Zhang, W. J. Ingram, Y. J. Cho, Y. Hathout, K. Brown, B. R. Rood, M. Handler, T. Hankinson, B. K. Kleinschmidt-Demasters, S. Hutter, D. T. Jones, N. Kagawa, R. Hirayama, N. Kijima, Y. Chiba, M. Kinoshita, K. Takano, D. Eino, S. Fukuya, F. Yamamoto, K. Nakanishi, N. Hashimoto, Y. Hashii, J. Hara, T. Yoshimine, J. Wang, C. Guo, Q. Yang, Z. Chen, I. Filipek, E. Swieszkowska, M. Tarasinska, D. Perek, R. Kebudi, B. Koc, O. Gorgun, F. Y. Agaoglu, J. Wolff, E. Darendeliler, K. Kerl, J. Gronych, J. McGlade, R. Endersby, H. Hii, T. Johns, J. Sastry, D. Murphy, M. Ronghe, C. Cunningham, F. Cowie, R. Jones, A. Calisto, M. Sangra, C. Mathieson, J. Brown, K. Phuakpet, V. Larouche, U. Bartels, T. Ishida, D. Hasegawa, K. Miyata, S. Ochi, A. Saito, A. Kozaki, T. Yanai, K. Kawasaki, K. Yamamoto, A. Kawamura, T. Nagashima, Y. Akasaka, T. Soejima, M. Yoshida, Y. Kosaka, A. von Bueren, T. Goschzik, R. Kortmann, K. von Hoff, C. Friedrich, A. z. Muehlen, M. Warmuth-Metz, N. Soerensen, F. Deinlein, I. Zwiener, A. Faldum, J. Kuehl, K. KRAMER, N. P. -Taskar, P. Zanzonico, J. L. Humm, S. L. Wolden, N.-K. V. Cheung, S. Venkataraman, I. Alimova, P. Harris, D. Birks, I. Balakrishnan, A. Griesinger, N. K. Foreman, R. Vibhakar, A. Margol, N. Robison, J. Gnanachandran, L. Hung, R. Kennedy, M. Vali, G. Dhall, J. Finlay, A. Erdrich-Epstein, M. Krieger, R. Drissi, M. Fouladi, F. Gilles, A. Judkins, R. Sposto, S. Asgharzadeh, A. Peyrl, M. Chocholous, S. Holm, P. Grillner, K. Blomgren, A. Azizi, T. Czech, B. Gustafsson, K. Dieckmann, U. Leiss, I. Slavc, S. Babelyan, I. Dolgopolov, R. Pimenov, G. Mentkevich, S. Gorelishev, M. Laskov, A. O. von Bueren, J. Nowak, R. D. Kortmann, M. Mynarek, K. Muller, N. U. Gerber, H. Ottensmeier, R. Kwiecien, M. Yankelevich, V. Boyarshinov, I. Glekov, S. Ozerov, S. Gorelyshev, A. Popa, N. Subbotina, A. M. Martin, C. Nirschl, M. Polanczyk, R. Bell, D. Martinez, L. M. Sullivan, M. Santi, P. C. Burger, J. M. Taube, C. G. Drake, D. M. Pardoll, M. Lim, L. Li, W.-G. Wang, J.-X. Pu, H.-D. Sun, R. Ruggieri, M. H. Symons, M. I. Vanan, S. Bolin, S. Schumacher, R. Zeid, F. Yu, N. Vue, W. Gibson, B. Paolella, F. J. Swartling, M. W. Kieran, J. E. Bradner, O. Maher, S. Khatua, N. Tarek, W. Zaky, T. Gupta, S. Mohanty, S. Kannan, R. Jalali, E. Kapitza, D. Denkhaus, A. z. Muhlen, D. G. van Vuurden, M. Garami, J. Fangusaro, T. B. Davidson, M. J. G. da Costa, J. Sterba, S. C. Clifford, J. L. Finlay, R. Schmidt, J. Felsberg, H. Skladny, F. Cremer, G. Reifenberger, R. Kunder, E. Sridhar, A. A. Moiyadi, A. Goel, N. Goel, N. Shirsat, R. Othman, L. Storer, I. Kerr, B. Coyle, N. Law, M. L. Smith, M. Greenberg, S. Laughlin, D. Malkin, F. Liu, I. Moxon-Emre, N. Scantlebury, A. Nasir, D. Onion, A. Lourdusamy, A. Grabowska, Y. Cai, T. Bradshaw, R. S. S. de Medeiros, A. Beaugrand, S. Soares, S. Epelman, W. Wang, M. Sultan, R. J. Wechsler-Reya, M. Zapatka, B. Radlwimmer, D. Alderete, L. Baroni, F. Lubinieki, F. Auad, M. L. Gonzalez, W. Puya, P. Pacheco, O. Aurtenetxe, A. Gaffar, L. Gros, O. Cruz, C. Calvo, N. Shinojima, H. Nakamura, J.-i. Kuratsu, A. Hanaford, C. Eberhart, T. Archer, P. Tamayo, S. Pomeroy, E. Raabe, K. De Braganca, S. Gilheeney, Y. Khakoo, K. Kramer, S. Wolden, I. Dunkel, R. R. Lulla, J. Laskowski, S. Goldman, V. Gopalakrishnan, D. Shih, X. Wang, C. Faria, C. Raybaud, U. Tabori, J. Rutka, S. Jacobs, F. De Vathaire, I. Diallo, D. Llanas, C. Verez, F. Diop, A. Kahlouche, S. Puget, E. Thompson, E. Prince, V. Amani, P. Sin-Chan, M. Lu, C. Kleinman, T. Spence, D. Picard, K. C. Ho, J. Chan, J. Majewski, N. Jabado, P. Dirks, A. Huang, J. R. Madden, A. M. Donson, D. M. Mirsky, A. Dubuc, S. Mack, D. Gendoo, B. Luu, T. MacDonald, T. Van Meter, S. Croul, A. Laureano, W. Brugmann, C. Denman, H. Singh, H. Huls, J. Moyes, D. Sandberg, L. Silla, L. Cooper, and D. Lee
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Oncology ,Abstracts ,Cancer Research ,medicine.medical_specialty ,Cns pnet ,business.industry ,Internal medicine ,Meta-analysis ,medicine ,Neurology (clinical) ,business - Published
- 2014
4. PS998 JANUS KINASE AND CYTOKINE RECEPTOR MUTATIONS IN TRANSIENT ABNORMAL MYELOPOIESIS AND MYELOID LEUKEMIA IN CHILDREN WITH TRISOMY 21
- Author
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Stefan N. Constantinescu, Vyacheslav Amstislavskiy, Adrian Schwarzer, Mitchell J. Weiss, C. Garnett, M.-L. Yaspo, John D. Crispino, P.J. Campbell, Kenichi Yoshida, Leila N. Varghese, E. Papaemmanuil, D. Reinhardt, Jan-Henning Klusmann, M Labuhn, Sören Matzk, Kelly J. Perkins, T. Risch, Etsuro Ito, Seishi Ogawa, P. Vyas, Jeffrey W. Taub, V. Iotchkova, I. Roberts, Dirk Heckl, and C Scheer
- Subjects
business.industry ,Transient abnormal myelopoiesis ,medicine ,Cancer research ,Myeloid leukemia ,Hematology ,Janus kinase ,Cytokine receptor ,Trisomy ,medicine.disease ,business - Published
- 2019
5. S146 DECIPHERING THE ROLE OF RUNX1 ISOFORMS IN THE DEVELOPMENT OF TRANSIENT ABNORMAL MYELOPOIESIS
- Author
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S Gialesaki, S.-K. Kadel, Vyacheslav Amstislavskiy, L. Schmid, Dirk Heckl, T. Risch, D Bräuer-Hartmann, Jan-Henning Klusmann, M Labuhn, M.-L. Yaspo, F.-J. Strüwe, and Sören Matzk
- Subjects
Gene isoform ,chemistry.chemical_compound ,RUNX1 ,chemistry ,Transient abnormal myelopoiesis ,Hematology ,Biology ,Cell biology - Published
- 2019
6. OMICS AND PROGNSTIC MARKERS
- Author
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K. Adachi, H. Sasaki, S. Nagahisa, K. Yoshida, N. Hattori, Y. Nishiyama, T. Kawase, M. Hasegawa, M. Abe, Y. Hirose, A. Alentorn, Y. Marie, S. Poggioli, H. Alshehhi, B. Boisselier, C. Carpentier, K. Mokhtari, L. Capelle, D. Figarella-Branger, K. Hoang-Xuan, M. Sanson, J.-Y. Delattre, A. Idbaih, S. Yust-Katz, M. Anderson, A. Olar, A. Eterovic, N. Ezzeddine, K. Chen, H. Zhao, G. Fuller, K. Aldape, J. de Groot, N. Andor, J. Harness, S. G. Lopez, T. L. Fung, H. W. Mewes, C. Petritsch, A. Arivazhagan, K. Somasundaram, K. Thennarasu, P. Pandey, B. Anandh, V. Santosh, B. Chandramouli, A. Hegde, P. Kondaiah, M. Rao, R. Bell, R. Kang, C. Hong, J. Song, J. Costello, R. Nagarajan, B. Zhang, A. Diaz, T. Wang, L. Bie, Y. Li, H. Liu, W. F. C. Luyo, M. H. Carnero, M. E. P. Iruegas, A. R. Morell, M. C. Figueiras, R. L. Lopez, C. F. Valverde, A. K.-Y. Chan, J. C.-S. Pang, N. Y.-F. Chung, K. K.-W. Li, W. S. Poon, D. T.-M. Chan, Y. Wang, H.-a. K. Ng, M. Chaumeil, P. Larson, H. Yoshihara, D. Vigneron, S. Nelson, R. Pieper, J. Phillips, S. Ronen, V. Clark, Z. E. Omay, A. Serin, J. Gunel, B. Omay, C. Grady, M. Youngblood, K. Bilguvar, J. Baehring, J. Piepmeier, P. Gutin, A. Vortmeyer, C. Brennan, M. N. Pamir, T. Kilic, B. Krischek, M. Simon, K. Yasuno, M. Gunel, A. L. Cohen, M. Sato, K. D. Aldape, C. Mason, K. Diefes, L. Heathcock, L. Abegglen, D. Shrieve, W. Couldwell, J. D. Schiffman, H. Colman, Q. G. D'Alessandris, T. Cenci, M. Martini, L. Ricci-Vitiani, R. De Maria, L. M. Larocca, R. Pallini, B. Theeler, F. Lang, G. Rao, M. Gilbert, E. Sulman, R. Luthra, K. Eterovic, M. Routbort, R. Verhaak, G. Mills, J. Mendelsohn, F. Meric-Bernstam, A. Yung, K. MacArthur, S. Hahn, G. Kao, R. Lustig, M. Alonso-Basanta, S. Chandrasekaran, E. P. Wileyto, E. Reyes, J. Dorsey, K. Fujii, K. Kurozumi, T. Ichikawa, M. Onishi, J. Ishida, Y. Shimazu, B. Kaur, E. A. Chiocca, I. Date, C. Geisenberger, A. Mock, R. Warta, C. Schwager, C. Hartmann, A. von Deimling, A. Abdollahi, C. Herold-Mende, O. Gevaert, A. Achrol, S. Gholamin, S. Mitra, E. Westbroek, J. Loya, L. Mitchell, S. Chang, G. Steinberg, S. Plevritis, S. Cheshier, J. Xu, S. Napel, G. Zaharchuk, G. Harsh, D. Gutman, C. Holder, R. Colen, W. Dunn, R. Jain, L. Cooper, S. Hwang, A. Flanders, D. Brat, J. Hayes, A. Droop, H. Thygesen, M. Boissinot, D. Westhead, S. Short, S. Lawler, P. Bady, S. Kurscheid, M. Delorenzi, M. E. Hegi, C. Crosby, C. Faulkner, T. Smye-Rumsby, K. Kurian, M. Williams, K. Hopkins, A. Palmer, H. Williams, C. Wragg, H. R. Haynes, K. M. Kurian, P. White, T. Oka, L. Jalbert, A. Elkhaled, R. Jensen, K. Salzman, M. Schabel, D. Gillespie, M. Mumert, B. Johnson, T. Mazor, M. Barnes, S. Yamamoto, H. Ueda, K. Tatsuno, K. Aihara, A. Bollen, M. Hirst, M. Marra, A. Mukasa, N. Saito, H. Aburatani, M. Berger, B. Taylor, S. Popov, A. Mackay, W. Ingram, A. Burford, A. Jury, M. Vinci, C. Jones, D. T. W. Jones, V. Hovestadt, S. Picelli, W. Wang, P. A. Northcott, M. Kool, G. Reifenberger, T. Pietsch, M. Sultan, H. Lehrach, M.-L. Yaspo, A. Borkhardt, P. Landgraf, R. Eils, A. Korshunov, M. Zapatka, B. Radlwimmer, S. M. Pfister, P. Lichter, A. Joy, I. Smirnov, M. Reiser, W. Shapiro, S. Kim, B. Feuerstein, C. Jungk, S. Friauf, A. Unterberg, T. A. Juratli, J. McElroy, W. Meng, A. Huebner, K. D. Geiger, D. Krex, G. Schackert, A. Chakravarti, T. Lautenschlaeger, B. Y. Kim, W. Jiang, J. Beiko, S. Prabhu, F. DeMonte, R. Sawaya, D. Cahill, I. McCutcheon, C. Lau, L. Wang, K. Terashima, S. Yamaguchi, M. Burstein, J. Sun, T. Suzuki, R. Nishikawa, H. Nakamura, A. Natsume, S. Terasaka, H.-K. Ng, D. Muzny, R. Gibbs, D. Wheeler, X.-q. Zhang, S. Sun, K.-f. Lam, K. M. Y. Kiang, J. K. S. Pu, A. S. W. Ho, G. K. K. Leung, F. Loebel, W. T. Curry, F. G. Barker, N. Lelic, A. S. Chi, D. P. Cahill, D. Lu, J. Yin, C. Teo, K. McDonald, A. Madhankumar, C. Weston, B. Slagle-Webb, J. Sheehan, A. Patel, M. Glantz, J. Connor, C. Maire, J. Francis, C.-Z. Zhang, J. Jung, V. Manzo, V. Adalsteinsson, H. Homer, B. Blumenstiel, C. S. Pedamallu, E. Nickerson, A. Ligon, C. Love, M. Meyerson, K. Ligon, L. E. Jalbert, S. J. Nelson, A. W. Bollen, I. V. Smirnov, J. S. Song, A. B. Olshen, M. S. Berger, S. M. Chang, B. S. Taylor, J. F. Costello, S. Mehta, B. Armstrong, S. Peng, A. Bapat, M. Berens, B. Melendez, M. Mollejo, P. Mur, T. Hernandez-Iglesias, C. Fiano, J. Ruiz, J. A. Rey, V. Stadler, A. Schulte, K. Lamszus, C. Schichor, M. Westphal, J.-C. Tonn, O. Morozova, S. Katzman, M. Grifford, S. Salama, D. Haussler, A. Olshen, S. Fouse, S. Nakamizo, T. Sasayama, H. Tanaka, K. Tanaka, K. Mizukawa, M. Yoshida, E. Kohmura, P. Northcott, D. Jones, S. Pfister, R. Otani, S. Takayanagi, K. Saito, S. Tanaka, M. Shin, T. Ozawa, M. Riester, Y.-K. Cheng, J. Huse, K. Helmy, N. Charles, M. Squatrito, F. Michor, E. Holland, M. Perrech, L. Dreher, G. Rohn, R. Goldbrunner, M. Timmer, B. Pollo, V. Palumbo, C. Calatozzolo, M. Patane, R. Nunziata, M. Farinotti, A. Silvani, S. Lodrini, G. Finocchiaro, E. Lopez, A. Rioscovian, R. Ruiz, G. Siordia, A. P. de Leon, C. Rostomily, R. Rostomily, D. Silbergeld, D. Kolstoe, M. Chamberlain, J. Silber, P. Roth, A. Keller, J. Hoheisel, P. Codo, A. Bauer, C. Backes, P. Leidinger, E. Meese, E. Thiel, A. Korfel, M. Weller, G. Nagae, M. Nagane, J. Z. Sanborn, T. Mikkelsen, S. Jhanwar, L. Chin, M. Nishihara, M. Schliesser, C. Grimm, E. Weiss, R. Claus, D. Weichenhan, M. Weiler, T. Hielscher, F. Sahm, B. Wiestler, A.-C. Klein, J. Blaes, C. Plass, W. Wick, G. Stragliotto, A. Rahbar, C. Soderberg-Naucler, M. Won, R. Ezhilarasan, P. Sun, D. Blumenthal, M. Vogelbaum, R. Jenkins, R. Jeraj, P. Brown, K. Jaeckle, D. Schiff, J. Dignam, J. Atkins, D. Brachman, M. Werner-Wasik, M. Mehta, J. Shen, J. Luan, A. Yu, M. Matsutani, Y. Liang, T.-K. Man, A. Trister, M. Tokita, S. Mikheeva, A. Mikheev, S. Friend, M. van den Bent, L. Erdem, T. Gorlia, M. Taphoorn, J. Kros, P. Wesseling, H. Dubbink, A. Ibdaih, P. French, H. van Thuijl, J. Heimans, B. Ylstra, J. Reijneveld, A. Prabowo, I. Scheinin, H. van Essen, W. Spliet, C. Ferrier, P. van Rijen, T. Veersema, M. Thom, A. S.-v. Meeteren, E. Aronica, H. Kim, S. Zheng, D. J. Brat, S. Virk, S. Amini, C. Sougnez, J. Barnholtz-Sloan, R. G. W. Verhaak, C. Watts, A. Sottoriva, I. Spiteri, S. Piccirillo, A. Touloumis, P. Collins, J. Marioni, C. Curtis, S. Tavare, B. Tews, T. P. C. Yeung, B. Al-Khazraji, L. Morrison, L. Hoffman, D. Jackson, T.-Y. Lee, S. Yartsev, G. Bauman, J. Fu, R. Vegesna, Y. Mao, L. E. Heathcock, W. Torres-Garcia, S. Wang, A. McKenna, C. W. Brennan, W. K. A. Yung, J. N. Weinstein, E. P. Sulman, and D. Koul
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Abstracts ,Cancer Research ,Text mining ,Oncology ,business.industry ,Neurology (clinical) ,Computational biology ,Biology ,Omics ,business - Published
- 2013
7. Precision medicine for the treatment of metastatic uveal melanoma: A pilot study
- Author
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Thomas Kessler, C.A. Peuker, M. Schuette, Susen Burock, Mario Lamping, Damian T. Rieke, Ulrich Keilholz, Thomas Risch, Christoph Wierling, Reinhold Schaefer, K. Joehrens, M-L. Yaspo, Hans Lehrach, G. Poch, Serge Leyvraz, B. Lange, Felix Kiecker, Vyacheslav Amstislavskiy, Antonia M. Joussen, and Sebastian Ochsenreither
- Subjects
Oncology ,medicine.medical_specialty ,business.industry ,Internal medicine ,Melanoma ,Intraocular melanoma ,Medicine ,Hematology ,business ,medicine.disease - Published
- 2017
8. HIGH GRADE GLIOMAS AND DIPG
- Author
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C. F. Classen, D. William, M. Linnebacher, A. Farhod, W. Kedr, B. Elsabe, S. Fadel, S. Van Gool, S. De Vleeschouwer, C. Koks, A. Garg, M. Ehrhardt, M. Riva, P. Agostinis, N. Graf, T.-W. Yao, Y. Yoshida, J. Zhang, T. Ozawa, D. James, T. Nicolaides, R. Kebudi, F. B. Cakir, O. Gorgun, F. Y. Agaoglu, E. Darendeliler, A. Al-Kofide, E. Al-Shail, Y. Khafaga, H. Al-Hindi, M. Dababo, A. U. Haq, M. Anas, M. G. Barria, K. Siddiqui, M. Hassounah, M. Ayas, S. V. van Zanten, M. Jansen, D. van Vuurden, M. Huisman, D. Vugts, O. Hoekstra, G. van Dongen, G. Kaspers, J. Cockle, E. Ilett, K. Scott, A. Bruning-Richardson, S. Picton, S. Short, A. Melcher, M. Benesch, M. Warmuth-Metz, A. O. von Bueren, M. Hoffmann, T. Pietsch, R.-D. Kortmann, M. Eyrich, S. Rutkowski, M. C. Fruhwald, J. Faber, C. Kramm, M. Porkholm, L. Valanne, T. Lonnqvist, S. Holm, B. Lannering, P. Riikonen, D. Wojcik, A. Sehested, N. Clausen, A. Harila-Saari, E. Schomerus, H. K. Thorarinsdottir, P. Lahteenmaki, M. Arola, H. Thomassen, U. M. Saarinen-Pihkala, S.-M. Kivivuori, P. Buczkowicz, C. Hoeman, P. Rakopoulos, S. Pajovic, A. Morrison, E. Bouffet, U. Bartels, O. Becher, C. Hawkins, T. W. A. Gould, C. V. Rahman, S. J. Smith, D. A. Barrett, K. M. Shakesheff, R. G. Grundy, R. Rahman, N. Barua, D. Cronin, S. Gill, S. Lowisl, A. Hochart, C.-A. Maurage, N. Rocourt, M. Vinchon, O. Kerdraon, F. Escande, J. Grill, V. K. Pick, P. Leblond, G. Burzynski, T. Janicki, S. Burzynski, A. Marszalek, N. Ramani, W. Zaky, G. Kannan, A. Morani, D. Sandberg, L. Ketonen, O. Maher, F. Corrales-Medina, H. Meador, S. Khatua, M. Brassesco, L. Delsin, G. Roberto, C. Silva, L. Ana, E. Rego, C. Scrideli, K. Umezawa, L. Tone, S. J. Kim, C.-Y. Kim, I.-A. Kim, J. H. Han, B.-S. Choi, H. S. Ahn, H. S. Choi, F. Haque, R. Layfield, R. Grundy, L. Gandola, E. Pecori, V. Biassoni, E. Schiavello, C. Chiruzzi, F. Spreafico, P. Modena, F. Bach, E. Pignoli, M. Massimino, M. Drogosiewicz, B. Dembowska-Baginska, E. Jurkiewicz, I. Filipek, M. Perek-Polnik, E. Swieszkowska, D. Perek, S. Bender, D. T. Jones, H.-J. Warnatz, B. Hutter, T. Zichner, J. Gronych, A. Korshunov, R. Eils, J. O. Korbel, M.-L. Yaspo, P. Lichter, S. M. Pfister, S. Yadavilli, O. J. Becher, M. Kambhampati, R. J. Packer, J. Nazarian, F. C. Lechon, L. Fowkes, K. Khabra, L. M. Martin-Retortillo, L. V. Marshall, S. Vaidya, D.-M. Koh, M. O. Leach, A. D. Pearson, S. Zacharoulis, D. Schrey, G. Barone, E. Panditharatna, M. Stampar, A. Siu, H. Gordish-Dressman, J. Devaney, E. I. Hwang, A. H. Chung, R. K. Mittapalli, W. F. Elmquist, D. Castel, M.-A. Debily, C. Philippe, N. Truffaux, K. Taylor, R. Calmon, N. Boddaert, L. Le Dret, P. Saulnier, L. Lacroix, A. Mackay, C. Jones, S. Puget, C. Sainte-Rose, T. Blauwblomme, P. Varlet, N. Entz-Werle, C. Maugard, G. Bougeard, A. Nguyen, M. P. Chenard, A. Schneider, M. P. Gaub, M. Tsoli, A. Vanniasinghe, P. Luk, P. Dilda, M. Haber, P. Hogg, D. Ziegler, S. Simon, M. Monje, K. Gurova, A. Gudkov, M. Zapotocky, M. Churackova, B. Malinova, J. Zamecnik, M. Kyncl, M. Tichy, A. Puchmajerova, J. Stary, D. Sumerauer, J. Boult, M. Vinci, L. Perryman, G. Box, A. Jury, S. Popov, W. Ingram, S. Eccles, S. Robinson, S. Emir, H. A. Demir, C. Bayram, F. Cetindag, G. B. Kabacam, A. Fettah, J. Li, Y. Jamin, C. Cummings, J. Bamber, R. Sinkus, M. Nandhabalan, L. Bjerke, A. Burford, A. von Bueren, M. Baudis, P. Clarke, I. Collins, P. Workman, N. Olaciregui, J. Mora, A. Carcaboso, A. Bullock, M. Alonso, C. de Torres, O. Cruz, E. Pencreach, F. M. Moussalieh, D. Guenot, I. Namer, I. Pollack, R. Jakacki, L. Butterfield, R. Hamilton, A. Panigrahy, D. Potter, A. Connelly, S. Dibridge, T. Whiteside, H. Okada, S. Ahsan, E. Raabe, M. Haffner, K. Warren, M. Quezado, L. Ballester, C. Eberhart, F. Rodriguez, C. Ramachandran, S. Nair, K.-W. Quirrin, Z. Khatib, E. Escalon, S. Melnick, M. Hofmann, I. Schmid, T. Simon, E. Maass, A. Russo, G. Fleischhack, M. Becker, H. Hauch, A. Sander, C. Grasso, N. Berlow, L. Liu, L. Davis, E. Huang, P. Woo, Y. Tang, A. Ponnuswami, S. Chen, Y. Huang, M. Hutt-Cabezas, L. Dret, P. Meltzer, H. Mao, J. Abraham, M. Fouladi, M. N. Svalina, N. Wang, E. Hulleman, X.-N. Li, C. Keller, P. T. Spellman, R. Pal, M. H. A. Jansen, A. C. P. Sewing, T. Lagerweij, D. J. Vuchts, D. G. van Vuurden, V. Caretti, P. Wesseling, G. J. L. Kaspers, K. Cohen, M. Pearl, M. Kogiso, L. Zhang, L. Qi, H. Lindsay, F. Lin, S. Berg, J. Muscal, N. Amayiri, U. Tabori, B. Campbel, D. Bakry, M. Aronson, C. Durno, S. Gallinger, D. Malkin, I. Qaddumi, A. Musharbash, M. Swaidan, M. Al-Hussaini, S. Shandilya, C. McCully, R. Murphy, S. Akshintala, D. Cole, R. P. Macallister, R. Cruz, B. Widemann, R. Salloum, A. Smith, M. Glaunert, A. Ramkissoon, S. Peterson, S. Baker, L. Chow, J. Sandgren, S. Pfeifer, S. Popova, I. Alafuzoff, T. D. de Stahl, S. Pietschmann, M. J. Kerber, I. Zwiener, G. Henke, K. Muller, N. Y.-F. Sieow, R. H. M. Hoe, A. M. Tan, M. Y. Chan, S. Y. Soh, K. Burrell, Y. Chornenkyy, M. Remke, B. Golbourn, M. Barzczyk, M. Taylor, J. Rutka, P. Dirks, G. Zadeh, S. Agnihotri, R. Hashizume, Y. Ihara, N. Andor, X. Chen, R. Lerner, X. Huang, M. Tom, D. Solomon, S. Mueller, C. Petritsch, Z. Zhang, N. Gupta, T. Waldman, A. Dujua, J. Co, F. Hernandez, D. Doromal, M. Hegde, A. Wakefield, V. Brawley, Z. Grada, T. Byrd, K. Chow, S. Krebs, H. Heslop, S. Gottschalk, E. Yvon, N. Ahmed, G. Cornilleau, J. Paulsson, F. Andreiuolo, L. Guerrini-Rousseau, B. Geoerger, G. Vassal, A. Ostman, D. W. Parsons, L. R. Trevino, F. Gao, X. Shen, O. Hampton, M. Kosigo, P. A. Baxter, J. M. Su, M. Chintagumpala, R. Dauser, A. Adesina, S. E. Plon, D. A. Wheeler, C. C. Lau, G. Gielen, A. z. Muehlen, R. Kwiecien, J. Wolff, R. R. Lulla, J. Laskowski, S. Goldman, V. Gopalakrishnan, J. Fangusaro, M. Kieran, A. Fontebasso, S. Papillon-Cavanagh, J. Schwartzentruber, H. Nikbakht, N. Gerges, P.-O. Fiset, D. Bechet, D. Faury, N. De Jay, L. Ramkissoon, A. Corcoran, D. Jones, D. Sturm, P. Johann, T. Tomita, M. Nagib, A. Bendel, L. Goumnerova, D. C. Bowers, J. R. Leonard, J. B. Rubin, T. Alden, A. DiPatri, S. Browd, S. Leary, G. Jallo, M. D. Prados, A. Banerjee, A.-S. Carret, B. Ellezam, L. Crevier, A. Klekner, L. Bognar, P. Hauser, M. Garami, J. Myseros, Z. Dong, P. M. Siegel, W. Gump, K. Ayyanar, J. Ragheb, M. Krieger, E. Kiehna, N. Robison, D. Harter, S. Gardner, M. Handler, N. Foreman, B. Brahma, T. MacDonald, H. Malkin, S. Chi, P. Manley, P. Bandopadhayay, L. Greenspan, A. Ligon, S. Albrecht, K. L. Ligon, J. Majewski, N. Jabado, F. Cordero, K. Halvorson, I. Taylor, M. Hutt, M. Weingart, A. Price, M. Kantar, S. Onen, S. Kamer, T. Turhan, O. Kitis, Y. Ertan, N. Cetingul, Y. Anacak, T. Akalin, Y. Ersahin, G. Mason, C. Ho, F. Crozier, G. Vezina, R. Packer, E. Hwang, S. Gilheeney, N. Millard, K. DeBraganca, Y. Khakoo, K. Kramer, S. Wolden, M. Donzelli, C. Fischer, M. Petriccione, I. Dunkel, S. Afzal, A. Fleming, V. Larouche, S. Zelcer, D. L. Johnston, M. Kostova, C. Mpofu, J.-C. Decarie, D. Strother, L. Lafay-Cousin, D. Eisenstat, C. Fryer, J. Hukin, M. Hsu, J. Lasky, T. Moore, L. Liau, T. Davidson, R. Prins, T. Hassal, J. Baugh, J. Kirkendall, R. Doughman, J. Leach, B. Jones, L. Miles, D. Hargrave, T. Jacques, S. Savage, D. Saunders, R. Wallace, B. Flutter, D. Morgenestern, E. Blanco, K. Howe, M. Lowdell, E. Samuel, A. Michalski, J. Anderson, Y. Arakawa, K. Umeda, K.-i. Watanabe, T. Mizowaki, M. Hiraoka, H. Hiramatsu, S. Adachi, T. Kunieda, Y. Takagi, S. Miyamoto, S. Venneti, M. Santi, M. M. Felicella, L. M. Sullivan, I. Dolgalev, D. Martinez, A. Perry, P. W. Lewis, D. C. Allis, C. B. Thompson, and A. R. Judkins
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Oncology ,Cancer Research ,medicine.medical_specialty ,business.industry ,03 medical and health sciences ,Abstracts ,0302 clinical medicine ,Text mining ,030220 oncology & carcinogenesis ,Internal medicine ,medicine ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Published
- 2014
9. The DNA sequence of human chromosome 21
- Author
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M, Hattori, A, Fujiyama, T D, Taylor, H, Watanabe, T, Yada, H S, Park, A, Toyoda, K, Ishii, Y, Totoki, D K, Choi, Y, Groner, E, Soeda, M, Ohki, T, Takagi, Y, Sakaki, S, Taudien, K, Blechschmidt, A, Polley, U, Menzel, J, Delabar, K, Kumpf, R, Lehmann, D, Patterson, K, Reichwald, A, Rump, M, Schillhabel, A, Schudy, W, Zimmermann, A, Rosenthal, J, Kudoh, K, Schibuya, K, Kawasaki, S, Asakawa, A, Shintani, T, Sasaki, K, Nagamine, S, Mitsuyama, S E, Antonarakis, S, Minoshima, N, Shimizu, G, Nordsiek, K, Hornischer, P, Brant, M, Scharfe, O, Schon, A, Desario, J, Reichelt, G, Kauer, H, Blocker, J, Ramser, A, Beck, S, Klages, S, Hennig, L, Riesselmann, E, Dagand, T, Haaf, S, Wehrmeyer, K, Borzym, K, Gardiner, D, Nizetic, F, Francis, H, Lehrach, R, Reinhardt, M L, Yaspo, and Antonarakis, Stylianos
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ddc:616 ,Genetics ,Multidisciplinary ,Autosome ,Base Sequence ,Contig ,Gene map ,Chromosomes, Human, Pair 21 ,Molecular Sequence Data ,Chromosome Mapping ,Chromosome ,DNA ,Dna ,Sequence Analysis, DNA ,Genome project ,Biology ,Genes ,Chromosome 19 ,Mutation ,Humans ,Down Syndrome ,Chromosome 21 ,Chromosome 22 ,Down Syndrome/genetics - Abstract
Chromosome 21 is the smallest human autosome. An extra copy of chromosome 21 causes Down syndrome, the most frequent genetic cause of significant mental retardation, which affects up to 1 in 700 live births. Several anonymous loci for monogenic disorders and predispositions for common complex disorders have also been mapped to this chromosome, and loss of heterozygosity has been observed in regions associated with solid tumours. Here we report the sequence and gene catalogue of the long arm of chromosome 21. We have sequenced 33,546,361 base pairs (bp) of DNA with very high accuracy, the largest contig being 25,491,867 bp. Only three small clone gaps and seven sequencing gaps remain, comprising about 100 kilobases. Thus, we achieved 99.7% coverage of 21q. We also sequenced 281,116 bp from the short arm. The structural features identified include duplications that are probably involved in chromosomal abnormalities and repeat structures in the telomeric and pericentromeric regions. Analysis of the chromosome revealed 127 known genes, 98 predicted genes and 59 pseudogenes.
- Published
- 2000
10. Abstracts of the 35th American Cytogenetics Conference
- Author
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S. Sakon, M. Hori, Tom Goldammer, P. Stanier, H. Nishimori, S. Châtelin, L.D. Coogle, J. Kaplan, W.J. Kimberling, H.C. Ardley, A.J. Brookes, H. Hirota, C. Janish, J. Eddleston, R. Matsuoka, Manfred Schwerin, M.Z. Limongi, K. Akagawa, A. Vilain, M. Schmid, M.H. Adams, M. Tamari, T. Kawabe, T. Katagiri, D. Diamond, X. Wang, D. Sundaramurthy, S. Ishikawa, M. Mihara, J. Surrallés, S. Sonta, G. Meroni, P.A. Robinson, G. Del Sal, K.S. Reddy, A. Munnich, F.C. Kischkel, O.T. Tap, G. Della Valle, L.F. Pieri, J. Neesen, Y. Daigo, E. Viegas-Péquignot, F.S. Grass, E. Crawford, K. Weipoltshammer, I. Perrault, R.P. Kimberly, G.R. Rutteman, K.J. McDowell, F. Wachtler, Y. Nakamura, K.S. Theil, T. Ono, K. Gardiner, K.J. Fowler, T. Tetsuka, T. Emahazion, R.G. Brzyski, J. McKeand, B. Malfoy, A.J. Copp, C.M. Moore, D. Molina-Gomez, P. Calvas, R.G. Best, P. Franz, A. Ueno, D.M. Hoover, M. Yokoyama, H. Otsuka, L. Gaddini, T. Nakada, M. Tham, M. Gostissa, O. Maruyama, J. Vanselow, A. Beskow, D.A. Campbell, M.R. Koehler, N. Shimizu, K.H.A. Choo, K. Mikoshiba, J.B. Kenyon, K. Kirschhofer, J.N. Murdoch, A.A. Bosma, H. Satoh, S. Weitz, S. Abu-Hayyeh, J.-M. Rozet, H. Yagita, C. Sreekantaiah, A. Poustka, C. Zijlstra, C.L. Anderson, N.A. de Haan, M.-L. Yaspo, P. Sandy, V. Sulcova, U. Gyllensten, N.D. Sullivan, T. Toki, A.A. Szalay, J. Rogers, Y. Miki, K. Chida, L.L. Culley, D.F. Hudson, T.L. Lear, D. Soenksen, J.-P. Yang, F. Pelliccia, M. Yamamoto, M.M. Bouzyk, X. Li, F. Apiou, K. Kogame, D.V. Irvine, M.M. Leland, T. Kuroki, R. Saffery, A. Rocchi, D.L. Maresco, B. Dutrillaux, H. Nakano, A.T. Natarajan, R. Fürbass, P. Lichter, K. Okumura, E. Souied, E. Ito, J.P. Leek, M. Kimura, A.F. Markham, Ronald M. Brunner, P. Kioschis, P.H. Krammer, S. Saccone, S. Gerber, T. Iwata, B.T. Kile, H.E. Trowell, Y. Shimizu, M. Shindo, T. Nakayama, T. Okamoto, E. Bailey, L.E. Blue, and S.M. Witte
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medicine.medical_specialty ,Genetics ,Cytogenetics ,medicine ,Library science ,Biology ,Molecular Biology ,Genetics (clinical) - Published
- 1998
11. Molecular cloning and characterization of the Fugu rubripes MEST/COPG2 imprinting cluster and chromosomal localization in Fugu and Tetraodon nigroviridis
- Author
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B, Brunner, F, Grützner, M L, Yaspo, H H, Ropers, T, Haaf, and V M, Kalscheuer
- Subjects
Sequence Homology, Amino Acid ,Corticotropin-Releasing Hormone ,Molecular Sequence Data ,Fishes ,Vesicular Transport Proteins ,Chromosome Mapping ,Proteins ,Sequence Analysis, DNA ,Cosmids ,Coatomer Protein ,DNA-Binding Proteins ,Genomic Imprinting ,Mice ,Culture Techniques ,Multigene Family ,Animals ,Humans ,Amino Acid Sequence ,Cloning, Molecular ,In Situ Hybridization, Fluorescence ,Urocortins ,Zebrafish - Abstract
We isolated Fugu genomic clones using the human MEST (Mesoderm-Specific Transcript) cDNA as probe. Sequence analysis revealed the presence of MEST and three additional genes which show homology to plant DNBP (DNA-Binding Protein), vertebrate COPG2 (Coat Protein Gamma 2), as well as to human and mouse UCN (Urocortin). Structures of Fugu and human MEST, COPG2 and UCN genes are very similar. Since MEST and COPG2 are neighboring genes on human chromosome 7q32, we can conclude that we identified their orthologs and that linkage of these genes is evolutionarily conserved in vertebrates. Unlike human MEST which underlies isoform-specific imprinting and is methylated in a parent-of-origin-specific fashion, the CpG island of the Fugu ortholog is completely methylated. The translation start of Fugu MEST is identical to the non-imprinted human isoform which is in good agreement with the assumption that genomic imprinting is restricted to mammals. Comparative mapping of these genes by fluorescence in-situ hybridization to metaphase chromosomes of Fugu rubripes and Tetraodon nigroviridis showed clear signals on one of the smallest acrocentric chromosomal pairs, which in Fugu, can be easily classified by its unique triangular shape.
- Published
- 2000
12. The mouse Aire gene: comparative genomic sequencing, gene organization, and expression
- Author
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K, Blechschmidt, M, Schweiger, K, Wertz, R, Poulson, H M, Christensen, A, Rosenthal, H, Lehrach, and M L, Yaspo
- Subjects
Letter ,Molecular Sequence Data ,Chromosome Mapping ,Gene Expression ,Zinc Fingers ,Sequence Analysis, DNA ,Thymus Gland ,DNA-Binding Proteins ,Mice ,Organ Specificity ,Sequence Homology, Nucleic Acid ,Animals ,Humans ,Amino Acid Sequence ,Polyendocrinopathies, Autoimmune ,Sequence Alignment ,In Situ Hybridization ,Transcription Factors - Abstract
Mutations in the human AIRE gene (hAIRE) result in the development of an autoimmune disease named APECED (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy; OMIM 240300). Previously, we have cloned hAIRE and shown that it codes for a putative transcription-associated factor. Here we report the cloning and characterization of Aire, the murine ortholog of hAIRE. Comparative genomic sequencing revealed that the structure of the AIRE gene is highly conserved between human and mouse. The conceptual proteins share 73% homology and feature the same typical functional domains in both species. RT–PCR analysis detected three splice variant isoforms in various mouse tissues, and interestingly one isoform was conserved in human, suggesting potential biological relevance of this product. In situ hybridization on mouse and human histological sections showed that AIRE expression pattern was mainly restricted to a few cells in the thymus, calling for a tissue-specific function of the gene product.
- Published
- 1999
13. Mapping ESTs by fiber-FISH
- Author
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N, Horelli-Kuitunen, J, Aaltonen, M L, Yaspo, M, Eeva, M, Wessman, L, Peltonen, and A, Palotie
- Subjects
Expressed Sequence Tags ,Contig Mapping ,Transcription, Genetic ,Chromosomes, Human, Pair 21 ,Methods ,food and beverages ,Chromosome Mapping ,Humans ,Reproducibility of Results ,3' Untranslated Regions ,Sensitivity and Specificity ,In Situ Hybridization, Fluorescence - Abstract
A visual transcript map of six genes was constructed on the chromosome 21q22.3 by high resolution fluorescence in situ hybridization (FISH). Expressed sequence tags (ESTs) from six genes—PWP2, KNP1, AIRE, C21orf3, SMT3A, and C21orf1—were successfully localized by fiber–FISH by use of sensitive tyramide-based detection. The sizes of the ESTs varied between 315 to 956 bp and most of them map within the 3′-untranslated region. The ESTs were assigned to and subsequently ordered within cosmid, PAC, and BAC clones hybridized on DNA fibers. Physical distances between ESTs and known markers were determined. Our results demonstrate the feasibility and accuracy of visual mapping EST sequences in relation to known markers. The main advantage of this approach is that it can be applied to finely map any of the database ESTs for positional cloning efforts. The sensitivity, specificity, and reproducibility of this high-resolution EST mapping technique is evaluated.
- Published
- 1999
14. A new member of the proprotein convertase gene family (LPC) is located at a chromosome translocation breakpoint in lymphomas
- Author
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J, Meerabux, M L, Yaspo, A J, Roebroek, W J, Van de Ven, T A, Lister, and B D, Young
- Subjects
Chromosomes, Human, Pair 14 ,Gene Rearrangement ,Base Sequence ,Chromosomes, Human, Pair 11 ,Lymphoma, Non-Hodgkin ,Molecular Sequence Data ,Serine Endopeptidases ,Humans ,Amino Acid Sequence ,Subtilisins ,Cloning, Molecular ,Blotting, Northern ,Translocation, Genetic - Abstract
A new member of the proprotein convertase gene family (LPC) has been identified at a chromosome translocation breakpoint occurring in a high grade lymphoma. The translocation t(11;14)(q23;q32) has been molecularly cloned and shown to be the result of a fusion between an intron in the 3' -untranslated region of LPC with a sequence close to the switch region S gamma 4 of the IGH locus. The LPC gene encodes a protein of 785 amino acids with substantial homology to furin and the other members of the proprotein convertase family and represents a novel target for chromosome translocation and subsequent deregulation.
- Published
- 1996
15. Molecular analysis of 12 patients with the t(8;21) translocation and M2 acute myelogenous leukemia
- Author
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M L, Yaspo, D, Theophile, A, Aurias, N, Créte, N, Créau-Goldberg, C, Bastard, A M, Suberville, F, Valensi, F, Viguier, and R, Berger
- Subjects
Adult ,Male ,Adolescent ,Chromosomes, Human, Pair 21 ,Restriction Mapping ,Middle Aged ,Translocation, Genetic ,Electrophoresis, Gel, Pulsed-Field ,Blotting, Southern ,Leukemia, Myeloid, Acute ,Humans ,Female ,Child ,DNA Probes ,Aged ,Chromosomes, Human, Pair 8 - Abstract
The t(8;21)(q22;q22) is a nonrandom cytogenetic abnormality associated with acute myelogenous leukemia of the M2 subtype (FAB classification). The 8q- and 21q+ derivative chromosomes have previously been isolated in somatic cell hybrids and used to map the anonymous sequences D21S65 and D21S17, which were proximal and distal, respectively, to the breakpoint on chromosome 21. DNA from a series of 12 t(8;21) patients and 7 controls was analyzed by pulsed field gel electrophoresis. Physical linkage of probes D21S65 and D21S17 on a 2100 kb NruI fragment was established by partial digestion experiments. In all the patients, the translocation generated a rearranged D21S65 NruI fragment of 650 to 750 kb, suggesting heterogeneity in the breakpoints. This heterogeneity was confirmed by using BssHII, SacII, and EagI enzymes. Our results are consistent with the presence of a 100 Kb breakpoint cluster region on chromosome 21 encompassing the AML1 gene. Interestingly, in half of the patients, demethylation of an NruI site located 7 kb proximal to the last exon of the AML1 gene occurred on the nontranslocated chromosome 21.
- Published
- 1992
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