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Your search keyword '"M. Yu. Sheremet"' showing total 3 results
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3 results on '"M. Yu. Sheremet"'

1. Efficacy and safety of lenvatinib and pembrolizumab in the treatment of endometrial cancer: data from routine clinical practice in Russia

Author

A. A. Rumyantsev, A. E. Protasova, M. Yu. Sheremet, A. Yu. Goryainova, M. V. Volkonskiy, A. G. Kedrova, S. V. Kuzmicheva, O. N. Aymamedova, Kh. S. Musaeva, S. M. Soroka, O. V. Romanchuk, V. N. Orlova, N. G. Graft, M. R. Ibragimova, Yu. I. Merzlikina, L. V. Stepura, L. B. Tatulova, A. A. Abasova, A. A. Akopyan, E. V. Arsenyeva, Yu. V. Vasilyeva, A. V. Belonogov, L. V. Krivolapova, A. A. Bobryshev, D. Yu. Vovk, I. A. Luev, N. R. Abidova, R. S. Zhikhorev, T. A. Zhelezkova, T. T. Grigoryan, T. A. Makarkina, V. A. Ekimov, A. V. Zhizhina, E. V. Karabina, O. A. Kuchevskaya, V. M. Filippova, T. A. Linchenko, A. A. Lisaeva, A. N. Fedorova, K. S. Maystrenko, E. V. Markizova, E. V. Kogay, E. P. Krasnorutskaya, M. E. Popova, Yu. Yu. Pchelin, R. A. Ryanzhina, D. B. Sidorov, E. B. Shakhnovich, S. M. Alekseev, M. V. Zinkevich, I. O. Belogortsev, V. A. Chubenko, V. M. Moiseenko, N. Kh. Abduloeva, A. A. Lebedinets, L. V. Strakh, L. K. Semenov, M. B. Bolieva, and F. Z. Aydaeva

Subjects
targeted therapy, pembrolizumab, lenvatinib, endometrial cancer, routine clinical practice, Gynecology and obstetrics, RG1-991
Abstract

Aim. To assess the efficacy and safety of lenvatinib and pembrolizumab for the treatment of mismatch repair-proficient endometrial cancer (EC) in routine clinical practice in Russia.Materials and methods. This multicenter, retrospective, cohort study included patients with recurrent and metastatic EC from 37 cancer centers in Russia treated between May 2020 and April 2023. Patients with histologically verified EC without microsatellite instability who received ≥1 course of pembrolizumab/lenvatinib therapy were included in the study. The primary endpoint was progression-free survival; the clinical characteristics of the patients were additionally analyzed, the objective response rate and the toxicity profile of therapy were assessed.Results. The study included 100 patients. Median age was 65 (30–83) years. The most common histologic tumor subtype was endometrioid adenocarcinoma (68 %); serous adenocarcinoma was diagnosed in 22 % of cases, other types of tumor – 10 % of cases. All patients had pMMR/microsatellite-stable tumors. The median progression-free survival was 7.75 months (95 % confidence interval 0.7–33.8), and a partial response to therapy was observed in 24 % of patients. Almost half of the patients (44 %) required dose reduction due to adverse events. The most common adverse events included fatigue (n = 26; 26 %), hypertension (n = 20; 20 %), and hypothyroidism (n = 14; 14 %).Conclusion. This study confirms the clinical efficacy of lenvatinib and pembrolizumab in patients with recurrent and metastatic EC without mismatch repair system deficiency (pMMR-tumors) in routine clinical practice.

Published
2024
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2. Features of a circadian rhythm of arterial pressure in patients with resistant arterial hypertension and pseudo-resistant arterial hypertension

Author

M. Yu. Sheremet

Subjects
medicine.medical_specialty, Ambulatory blood pressure, Blood transfusion, business.industry, medicine.medical_treatment, Group ii, Normal circadian rhythm, Blood pressure, Internal medicine, medicine, Cardiology, General Earth and Planetary Sciences, Circadian rhythm, Diuretic, business, General Environmental Science, Morning
Abstract

Aim: To determine the peculiarities of circadian rhythm of arterial pressure in patients with true resistant arterial hypertension (RAH) and pseudo-resistant arterial hypertension (PRAH). Material and methods. 52 patients with suspected resistant arterial hypertension (RAH) were examined according to the criteria of the European Society of Hypertension (ESH, 2013). Antihypertensive therapy (ACE inhibitors/sartans, calcium antagonist, and a diuretic) was administered to 44 patients with suspected RAH in the maximum therapeutic doses. In 20 patients, with the combined therapy, the normalization of blood pressure was not achieved. The presence of RAH confirmed it. These patients formed group I. However, blood pressure in 24 examined patients was normalized, indicating a pseudo-reflective course of hypertension. These patients formed a control group (group II). The measurements of the office and ambulatory blood pressure were performed in all patients for assessing the characteristics of a circadian rhythm of blood pressure. Results. According to ambulatory blood pressure monitoring (ABPM), in patients with RAH, a significantly higher level of systolic blood pressure (SBP) was recorded daily, during daytime and nighttime, as well as mean night value of diastolic blood pressure (DBP). The daily indices of SBP and DNP were significantly lower in the group of patients with RBP. Insufficient reduction of blood pressure (type "non-dipper") was observed in 8 (35%) patients in nighttime; "Nigh-piker" — in 5 patients (25%). The rest of the patients had a normal circadian rhythm profile of BP. In group II, 11 (45.8%) patients had normal daily blood transfusion profile, 8 (33.4%) patients had non-dipper disorders, only 2 patients had nigh-piker type (8, 3%), and in three patients (12.5%) — recorded excessive decrease in blood pressure at night — over-dipper type. The disturbance of the variability of blood pressure were found more frequently in group І (72.7%) than in the ІІ group — 43.0% (р

Published
2018

3. Borohydride reduction of Ag+ in aqueous poly(acrylic acid-co-acrylamide) solutions

Author

M. Yu. Sheremet, V. F. Levchenko, F. A. Popov, and V. D. Buikliskii

Subjects
chemistry.chemical_compound, Sodium borohydride, Colloid and Surface Chemistry, Aqueous solution, Chemistry, Acrylamide, Inorganic chemistry, Surfaces and Interfaces, Physical and Theoretical Chemistry, Borohydride, Acrylic acid, Nuclear chemistry
Abstract

Silver clusters stabilized with poly(acrylic acid-co-acrylamide) are chemically synthesized via reduction of silver cations with sodium borohydride. Metallopolymer systems obtained at different concentrations of sodium borohydride in reaction mixtures are studied spectrophotometrically, and the effect of reductant content on the composition of the products is investigated.

Published
2012

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