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The population development of German municipalities is characterized by pronounced regional disparities. We seek to shed new light on the shifting patterns of population development in Germany at the local level between 1990 and 2019 to understand better the drivers of population development at the local level and to initiate a debate on the (dis)advantages of longitudinal analyses of population change at the local level and the resulting methodological challenges. We address three interrelated questions: (1) how do patterns of local population trends shift over time and in space? (2) Where are the hot and cold spots of population development, and how stable are they? (3) Are there any persistent outliers defying the regional trends of population development? We use a unique database that includes annual data on the population development of all German municipalities to answer these questions. Using spatial autocorrelation and hot-spot–cold-spot analysis, we identify short- and long-term population trajectories that allow us to detect both the hot and the cold spots of population development and islands of growth in otherwise shrinking regions and islands of decline in growing regions. Stable hot spots of population growth exist around Germany's three largest cities – Berlin, Hamburg and Munich – and in the rural northwest. The cold spots of population development are concentrated in rural regions of eastern Germany but also structurally weak, old industrialized rural regions around Brunswick and Kassel and in Upper Franconia, Saarland and Western Palatinate.

The most common approach to assessing natural hazard risk is investigating the willingness to pay in the presence or absence of such risk. In this work, we propose a new, machine-learning-based, indirect approach to the problem, i.e. through residential-choice modelling. Especially in urban environments, exposure and vulnerability are highly dynamic risk components, both being shaped by a complex and continuous reorganization and redistribution of assets within the urban space, including the (re-)location of urban dwellers. By modelling residential-choice behaviour in the city of Leipzig, Germany, we seek to examine how exposure and vulnerabilities are shaped by the residential-location-choice process. The proposed approach reveals hot spots and cold spots of residential choice for distinct socioeconomic groups exhibiting heterogeneous preferences. We discuss the relationship between observed patterns and disaster risk through the lens of exposure and vulnerability, as well as links to urban planning, and explore how the proposed methodology may contribute to predicting future trends in exposure, vulnerability, and risk through this analytical focus. Avenues for future research include the operational strengthening of these linkages for more effective disaster risk management.

The World Meteorological Organization (WMO) Solid Precipitation Intercomparison Experiment (SPICE) involved extensive field intercomparisons of automated instruments for measuring snow during the 2013/2014 and 2014/2015 winter seasons. A key outcome of SPICE was the development of transfer functions for the wind bias adjustment of solid precipitation measurements using various precipitation gauge and wind shield configurations. Due to the short intercomparison period, the data set was not sufficiently large to develop and evaluate transfer functions using independent precipitation measurements, although on average the adjustments were effective at reducing the bias in unshielded gauges from −33.4 % to 1.1 %. The present analysis uses data collected at eight SPICE sites over the 2015/2016 and 2016/2017 winter periods, comparing 30 min adjusted and unadjusted measurements from Geonor T-200B3 and OTT Pluvio2 precipitation gauges in different shield configurations to the WMO Double Fence Automated Reference (DFAR) for the evaluation of the transfer function. Performance is assessed in terms of relative total catch (RTC), root mean square error (RMSE), Pearson correlation (r), and percentage of events (PEs) within 0.1 mm of the DFAR. Metrics are reported for combined precipitation types and for snow only. The evaluation shows that the performance varies substantially by site. Adjusted RTC varies from 54 % to 123 %, RMSE from 0.07 to 0.38 mm, r from 0.28 to 0.94, and PEs from 37 % to 84 %, depending on precipitation phase, site, and gauge configuration (gauge and wind screen type). Generally, windier sites, such as Haukeliseter (Norway) and Bratt's Lake (Canada), exhibit a net under-adjustment (RTC of 54 % to 83 %), while the less windy sites, such as Sodankylä (Finland) and Caribou Creek (Canada), exhibit a net over-adjustment (RTC of 102 % to 123 %). Although the application of transfer functions is necessary to mitigate wind bias in solid precipitation measurements, especially at windy sites and for unshielded gauges, the variability in the performance metrics among sites suggests that the functions be applied with caution.

A critical aspect of predicting soil organic carbon (SOC) concentrations is the lack of available soil information; where information on soil characteristics is available, it is usually focused on regions of high agricultural interest. To date, in Chile, a large proportion of the SOC data have been collected in areas of intensive agricultural or forestry use; however, vast areas beyond these forms of land use have few or no soil data available. Here we present a new SOC database for the country, which is the result of an unprecedented national effort under the framework of the Global Soil Partnership. This partnership has helped build the largest database of SOC to date in Chile, named the Chilean Soil Organic Carbon database (CHLSOC), comprising 13 612 data points compiled from numerous sources, including unpublished and difficult-to-access data. The database will allow users to fill spatial gaps where no SOC estimates were publicly available previously. Presented values of SOC range from 6×10-5 % to 83.3 %, reflecting the variety of ecosystems that exist in Chile. The database has the potential to inform and test current models that predict SOC stocks and dynamics at larger spatial scales, thus enabling benefits from the richness of geochemical, topographic and climatic variability in Chile. The database is freely available to registered users at https://doi.org/10.17605/OSF.IO/NMYS3 (Pfeiffer et al., 2019b) under the Creative Commons Attribution 4.0 International Public License.

The study is focussing towards Metal Injection Moulding (MIM) of Mg-alloys for biomedical implant applications. Especially the influence of the sintering processing necessary for the consolidation of the finished part is in focus of this study. In doing so, the chosen high strength EZK400 Mg-alloy powder material was sintered using different sintering support bottom plate materials to evaluate the possibility of iron impurity pick up during sintering. It can be shown that iron pick up took place from the steel bottom plate into the specimen. Despite the fact that a separating boron nitrite (BN) barrier layer was used and the Mg-Fe phase diagram is not predicting any significant solubility to each other. As a result of this study a new bottom plate material not harming the sintering and the biodegradation performance of the as sintered material, namely a carbon plate material, was found. Keywords: Magnesium, Mg alloy, Sintering, MIM, Powder metallurgy, Biodegradable implant, EZK400

Weighing precipitation gauges are used widely for the measurement of all forms of precipitation, and are typically more accurate than tipping-bucket precipitation gauges. This is especially true for the measurement of solid precipitation; however, weighing precipitation gauge measurements must still be adjusted for undercatch in snowy, windy conditions. In WMO-SPICE (World Meteorological Organization Solid Precipitation InterComparison Experiment), different types of weighing precipitation gauges and shields were compared, and adjustments were determined for the undercatch of solid precipitation caused by wind. For the various combinations of gauges and shields, adjustments using both new and previously existing transfer functions were evaluated. For most of the gauge and shield combinations, previously derived transfer functions were found to perform as well as those more recently derived. This indicates that wind shield type (or lack thereof) is more important in determining the magnitude of wind-induced undercatch than the type of weighing precipitation gauge. It also demonstrates the potential for widespread use of the previously developed transfer functions. Another overarching result was that, in general, the more effective shields, which were associated with smaller unadjusted errors, also produced more accurate measurements after adjustment. This indicates that although transfer functions can effectively reduce measurement biases, effective wind shielding is still required for the most accurate measurement of solid precipitation.

Although precipitation has been measured for many centuries, precipitation measurements are still beset with significant inaccuracies. Solid precipitation is particularly difficult to measure accurately, and wintertime precipitation measurement biases between different observing networks or different regions can exceed 100 %. Using precipitation gauge results from the World Meteorological Organization Solid Precipitation Intercomparison Experiment (WMO-SPICE), errors in precipitation measurement caused by gauge uncertainty, spatial variability in precipitation, hydrometeor type, crystal habit, and wind were quantified. The methods used to calculate gauge catch efficiency and correct known biases are described. Adjustments, in the form of transfer functions that describe catch efficiency as a function of air temperature and wind speed, were derived using measurements from eight separate WMO-SPICE sites for both unshielded and single-Alter-shielded precipitation-weighing gauges. For the unshielded gauges, the average undercatch for all eight sites was 0.50 mm h−1 (34 %), and for the single-Alter-shielded gauges it was 0.35 mm h−1 (24 %). After adjustment, the mean bias for both the unshielded and single-Alter measurements was within 0.03 mm h−1 (2 %) of zero. The use of multiple sites to derive such adjustments makes these results unique and more broadly applicable to other sites with various climatic conditions. In addition, errors associated with the use of a single transfer function to correct gauge undercatch at multiple sites were estimated.

Hydrologic measurements are important for both the short- and long-term management of water resources. Of the terms in the hydrologic budget, precipitation is typically the most important input; however, measurements of precipitation are subject to large errors and biases. For example, an all-weather unshielded weighing precipitation gauge can collect less than 50 % of the actual amount of solid precipitation when wind speeds exceed 5 m s−1. Using results from two different precipitation test beds, such errors have been assessed for unshielded weighing gauges and for weighing gauges employing four of the most common windshields currently in use. Functions to correct wind-induced undercatch were developed and tested. In addition, corrections for the single-Alter weighing gauge were developed using the combined results of two separate sites in Norway and the USA. In general, the results indicate that the functions effectively correct the undercatch bias that affects such precipitation measurements. In addition, a single function developed for the single-Alter gauges effectively decreased the bias at both sites, with the bias at the US site improving from −12 to 0 %, and the bias at the Norwegian site improving from −27 to −4 %. These correction functions require only wind speed and air temperature as inputs, and were developed for use in national and local precipitation networks, hydrological monitoring, roadway and airport safety work, and climate change research. The techniques used to develop and test these transfer functions at more than one site can also be used for other more comprehensive studies, such as the World Meteorological Organization Solid Precipitation Intercomparison Experiment (WMO-SPICE).

Within the framework of the World Meteorological Organization Solid Precipitation Intercomparison Experiment (WMO-SPICE), the Thies tipping bucket precipitation gauge was assessed against the SPICE reference configuration at the Formigal–Sarrios test site located in the Pyrenees mountain range of Spain. The Thies gauge is the most widely used precipitation gauge by the Spanish Meteorological State Agency (AEMET) for the measurement of all precipitation types including snow. It is therefore critical that its performance is characterized. The first objective of this study is to derive transfer functions based on the relationships between catch ratio and wind speed and temperature. Multiple linear regression was applied to 1 and 3 h accumulation periods, confirming that wind is the most dominant environmental variable affecting the gauge catch efficiency, especially during snowfall events. At wind speeds of 1.5 m s−1 the tipping bucket recorded only 70 % of the reference precipitation. At 3 m s−1, the amount of measured precipitation decreased to 50 % of the reference, was even lower for temperatures colder than −2 °C and decreased to 20 % or less for higher wind speeds.The implications of precipitation underestimation for areas in northern Spain are discussed within the context of the present analysis, by applying the transfer function developed at the Formigal–Sarrios and using results from previous studies.

Staphylococcus aureus induces severe infective endocarditis (IE) where embolic complications are a major cause of death. Risk factors for embolism have been reported such as a younger age or larger IE vegetations, while methicillin resistance conferred by the mecA gene appeared as a protective factor. It is unclear, however, whether embolism is influenced by other S. aureus characteristics such as clonal complex (CC) or virulence pattern. We examined clinical and microbiological predictors of embolism in a prospective multicentric cohort of 98 French patients with monomicrobial S. aureus IE. The genomic contents of causative isolates were characterized using DNA array. To preserve statistical power, genotypic predictors were restricted to CC, secreted virulence factors and virulence regulators. Multivariate regularized logistic regression identified three independent predictors of embolism. Patients at higher risk were younger than the cohort median age of 62.5 y (adjusted odds ratio [OR] 0.14; 95% confidence interval [CI] 0.05–0.36). S. aureus characteristics predicting embolism were a CC30 genetic background (adjusted OR 9.734; 95% CI 1.53–192.8) and the absence of pIB485-like plasmid-borne enterotoxin-encoding genes sed, sej, and ser (sedjr; adjusted OR 0.07; 95% CI 0.004–0.457). CC30 S. aureus has been repeatedly reported to exhibit enhanced fitness in bloodstream infections, which might impact its ability to cause embolism. sedjr-encoded enterotoxins, whose superantigenic activity is unlikely to protect against embolism, possibly acted as a proxy to others genes of the pIB485-like plasmid found in genetically unrelated isolates from mostly embolism-free patients. mecA did not independently predict embolism but was strongly associated with sedjr. This mecA-sedjr association might have driven previous reports of a negative association of mecA and embolism. Collectively, our results suggest that the influence of S. aureus genotypic features on the risk of embolism may be stronger than previously suspected and independent of clinical risk factors.

The Extended-range Atmospheric Emitted Radiance Interferometer (E-AERI) is a moderate resolution (1 cm−1) Fourier transform infrared spectrometer for measuring the absolute downwelling infrared spectral radiance from the atmosphere between 400 and 3000 cm−1. The extended spectral range of the instrument permits monitoring of the 400–550 cm−1 (20–25 μm) region, where most of the infrared surface cooling currently occurs in the dry air of the Arctic. Spectra from the E-AERI have the potential to provide information about radiative balance, trace gases, and cloud properties in the Canadian high Arctic. Calibration, performance evaluation, and certification of the E-AERI were performed at the University of Wisconsin Space Science and Engineering Centre from September to October 2008. The instrument was then installed at the Polar Environment Atmospheric Research Laboratory (PEARL) Ridge Lab (610 m altitude) at Eureka, Nunavut, in October 2008, where it acquired one year of data. Measurements are taken every seven minutes year-round, including polar night when the solar-viewing spectrometers at PEARL are not operated. A similar instrument, the University of Idaho's Polar AERI (P-AERI), was installed at the Zero-altitude PEARL Auxiliary Laboratory (0PAL), 15 km away from the PEARL Ridge Lab, from March 2006 to June 2009. During the period of overlap, these two instruments provided calibrated radiance measurements from two altitudes. A fast line-by-line radiative transfer model is used to simulate the downwelling radiance at both altitudes; the largest differences (simulation-measurement) occur in spectral regions strongly influenced by atmospheric temperature and/or water vapour. The two AERI instruments at close proximity but located at two different altitudes are well-suited for investigating cloud forcing. As an example, it is shown that a thin, low ice cloud resulted in a 6% increase in irradiance. The presence of clouds creates a large surface radiative forcing in the Arctic, particularly in the 750–1200 cm−1 region where the downwelling radiance is several times greater than clear-sky radiances, which is significantly larger than in other more humid regions.

This paper presents extensive {bias determination} analyses of ozone observations from the Atmospheric Chemistry Experiment (ACE) satellite instruments: the ACE Fourier Transform Spectrometer (ACE-FTS) and the Measurement of Aerosol Extinction in the Stratosphere and Troposphere Retrieved by Occultation (ACE-MAESTRO) instrument. Here we compare the latest ozone data products from ACE-FTS and ACE-MAESTRO with coincident observations from nearly 20 satellite-borne, airborne, balloon-borne and ground-based instruments, by analysing volume mixing ratio profiles and partial column densities. The ACE-FTS version 2.2 Ozone Update product reports more ozone than most correlative measurements from the upper troposphere to the lower mesosphere. At altitude levels from 16 to 44 km, the average values of the mean relative differences are nearly all within +1 to +8%. At higher altitudes (45–60 km), the ACE-FTS ozone amounts are significantly larger than those of the comparison instruments, with mean relative differences of up to +40% (about +20% on average). For the ACE-MAESTRO version 1.2 ozone data product, mean relative differences are within ±10% (average values within ±6%) between 18 and 40 km for both the sunrise and sunset measurements. At higher altitudes (~35–55 km), systematic biases of opposite sign are found between the ACE-MAESTRO sunrise and sunset observations. While ozone amounts derived from the ACE-MAESTRO sunrise occultation data are often smaller than the coincident observations (with mean relative differences down to −10%), the sunset occultation profiles for ACE-MAESTRO show results that are qualitatively similar to ACE-FTS, indicating a large positive bias (mean relative differences within +10 to +30%) in the 45–55 km altitude range. In contrast, there is no significant systematic difference in bias found for the ACE-FTS sunrise and sunset measurements.

Animals must often choose between different quantities of objects in their environment, from food items to conspecifics. Yet we know little about how quantitative cognitive abilities compare across different types of objects. Previous research shows individuals use both the numerical difference (large − small) and numerical ratio (small/large) between two quantities to choose between them. This study investigated whether numerical difference and ratio predict preferences for quantities of food items and conspecifics in pinyon jays (Gymnorhinus cyanocephalus) using quantity preference tasks. In two replications of the food experiment (N = 12), pinyon jays chose larger quantities of mealworms more when numerical differences were large and numerical ratios were small. However, numerical difference did not influence food choice independently of ratio. In two replications of the social experiment (N = 20), when choosing between groups of conspecifics, pinyon jays did not prefer the larger over smaller group sizes and did not show numerical difference or ratio effects. Therefore, pinyon jays may use quantity information differently when deciding between quantities of food items and conspecifics. Whereas quantity was important for selecting food items, additional factors such as individual identity may be more important for selecting social groups to join. Thus, the type of objects offered can influence how animals use quantity information to choose among quantities.

Abstract Cri Du Chat syndrome, or 5p− syndrome, is characterized by a terminal or interstitial deletion on the short arm of chromosome 5 that causes variable clinical manifestations, including high-pitched cry in newborns, delayed growth, and global development. Different cytogenomic rearrangements, family history, and environmental factors may hinder the genotype–phenotype association. Thus, the phenotypic variability of this syndrome may not be limited only to variations in gene structure, such as deletions and duplications. It is possible that other mechanisms related to the activation or inactivation of promoters and/or exons of actively transcribed genes, such as DNA methylation are involved. Therefore, we studied the genome-wide methylation status profile of peripheral blood samples from fifteen patients with Cri du Chat Syndrome and nine control samples through the array method to look for Differentially Methylated Regions. We found that Differentially Methylated Regions outside the 5p region are mainly associated with regulating gene transcription, splicing, and chromatin remodeling. Most biological pathways are related to transcription, histone and chromatin binding, spliceosome and ribosomal complex, and RNA processing. Our results suggest that changes in the 5p region can cause an imbalance in other chromosomal regions capable of affecting gene modulation and thus explain the phenotypic differences in patients with 5p−.

To a certain degree, Eastern Boundary Current (EBC) ecosystems are similar: Cold bottom water from moderate depths, rich in nutrients, is transported to the euphotic zone by a combination of trade winds, Coriolis force and Ekman transport. The resultant high primary production fuels a rich secondary production in the upper pelagic and nearshore zones, but where O2 exchange is restricted, it creates oxygen minimum zones (OMZs) at shelf and upper slope (Humboldt and Benguela Current) or slope depths (California Current). These hypoxic zones host a specifically adapted, small macro- and meiofauna together with giant sulphur bacteria that use nitrate to oxydise H2S. In all EBC, small polychaetes, large nematodes and other opportunistic benthic species have adapted to the hypoxic conditions and co-exist with sulphur bacteria, which seem to be particularly dominant off Peru and Chile. However, a massive reduction of macrobenthos occurs in the core of the OMZ. In the Humboldt Current area the OMZ ranges between The properties described are valid for very cold and cold (La Niña and "normal") ENSO conditions with effective upwelling of nutrient-rich bottom water. During warm (El Niño) episodes, warm water masses of low oxygen concentration from oceanic and equatorial regions enter the upwelling zones, bringing a variety of (sub)tropical immigrants. The autochthonous benthic fauna emigrates to deeper water or poleward, or suffers mortality. However, some local macrofaunal species experience important population proliferations, presumably due to improved oxygenation (in the southern hemisphere), higher temperature tolerance, reduced competition or the capability to use different food. Both these negative and positive effects of El Niño influence local artisanal fisheries and the livelihood of coastal populations. In the Humboldt Current system the hypoxic seafloor at outer shelf depths receives important flushing from the equatorial zone, causing havoc on the sulphur bacteria mats and immediate recolonisation of the sediments by mega- and macrofauna. Conversely, off California, the intruding equatorial water masses appear to have lower oxygen than ambient waters, and may cause oxygen deficiency at upper slope depths. Effects of this change have not been studied in detail, although shrimp and other taxa appear to alter their distribution on the continental margin. Other properties and reactions of the two Pacific EBC benthic ecosystems to El Niño seem to differ, too, as does the overall impact of major episodes (e.g., 1982/1983(1984) vs. 1997/1998). The relation of the "Benguela Niño" to ENSO seems unclear although many Pacific-Atlantic ocean and atmosphere teleconnections have been described. Warm, low-oxygen equatorial water seems to be transported into the upwelling area by similar mechanisms as in the Pacific, but most major impacts on the eukaryotic biota obviously come from other, independent perturbations such as an extreme eutrophication of the sediments ensuing in sulphidic eruptions and toxic algal blooms. Similarities and differences of the Humboldt and California Current benthic ecosystems are discussed with particular reference to ENSO impacts since 1972/73. Where there are data available, the authors include the Benguela Current ecosystem as another important, non-Pacific EBC, which also suffers from the effects of hypoxia.

IntroductionThere is a growing concern about the threat of distractions in online learning environments. It has been suggested that mindfulness may attenuate the effects of distraction. The extent to which this translates to academic performance is under investigation. We aimed to investigate the relationship between task-irrelevant visual distraction, time pressure, and mindful self-regulated learning in the context of a low-stake computer-based assessment.MethodsThe study sampled 712 registered users of Prolific.co who were prescreened, current undergraduate university students. After data quality screening, 609 were retained for analyses. A 2 × 2 between-subjects design was used. Participants were randomly assigned to the following groups: (1) a control condition, (2) a distract condition, (3) a time pressure condition, or (4) a distract and time pressure condition. All participants completed reading comprehension questions, demographic questions, and the Mindful Self-Regulated Learning Scale.ResultsPresenting a visual distraction increased self-reported distraction and having a clock present increased self-reported time pressure. The distraction did not have a statistically significant effect on test performance. Mindfulness was negatively correlated with test performance, self-reported distraction, and self-reported time pressure.DiscussionContinuous task-irrelevant visual distractions may not be distracting enough to influence low-stakes testing performance, but they do influence self-perceptions.

The CIPA programme is a collaborative project including two entomologists from France and seven South and Central America countries. Its objective is the development of an expert system for computer aided identification of phlebotomine sandflies from the Americas. It also includes the formation of data bases for bibliographic, taxonomic and biogeographic data. Participant consensus on taxonomic prerequisites, standardization in bibliographic data collections and selection of descriptive variables for the final programme has been established through continous communication among participants and annual meetings. The adopted check-list of American sandflies presented here includes 386 specific taxa, ordered into genera and 28 sub-genera or species groups.

Reliable and valid measurement of trust in science and scientists is important. Assessing levels of such trust is important in determining attitudes and predicting behaviours in response to medical and scientific interventions targeted at managing public crises. However, trust is a complex phenomenon that has to be understood in relation to both distrust and mistrust. The Trust in Science and Scientists Scale has been adopted with increasing frequency in large-scale public health research. Detailed psychometric evaluation of the scale is overdue and makes meaningful comparisons between studies that use the scale difficult. Here, we examine the scale’s dimensionality across five separate samples. We find that two factors emerge that are divided by their item polarity. Implications for scale use and trust in science measurement are discussed.

Les crues répétées qu'a connues la France depuis 10 ans sont venues rappeler, parfois brutalement, la fragilité et les limites des digues de protection contre les inondations, ouvrages souvent anciens, construits par étapes et plus ou moins bien entretenus. Afin d'avoir une idée précise du parc des ouvrages concernés à l'échelle nationale, le ministère chargé de l'environnement a initié, en 1999, un recensement des digues de protection contre les inondations, de leurs gestionnaires, et des enjeux humains et économiques protégés. Le Cemagref a été chargé de la conception des outils, sous forme de base de données, dont il assure désormais la gestion et l'exploitation. La communication présente rapidement les objectifs, la structure et le support logiciel de la base de données puis, à partir des informations d'ores et déjà rassemblées, expose une première synthèse sur le patrimoine national des digues de protection contre les inondations et sur les nombreux enjeux liés à ces ouvrages.

Abstract Background Bladder cancer poses a significant public health burden, with high recurrence and progression rates in patients with non-muscle-invasive bladder cancer (NMIBC). Current treatment options include bladder-sparing therapies (BST) and radical cystectomy, both with associated risks and benefits. However, evidence supporting optimal management decisions for patients with recurrent high-grade NMIBC remains limited, leading to uncertainty for patients and clinicians. The CISTO (Comparison of Intravesical Therapy and Surgery as Treatment Options) Study aims to address this critical knowledge gap by comparing outcomes between patients undergoing BST and radical cystectomy. Methods The CISTO Study is a pragmatic, prospective observational cohort trial across 36 academic and community urology practices in the US. The study will enroll 572 patients with a diagnosis of recurrent high-grade NMIBC who select management with either BST or radical cystectomy. The primary outcome is health-related quality of life (QOL) at 12 months as measured with the EORTC-QLQ-C30. Secondary outcomes include bladder cancer-specific QOL, progression-free survival, cancer-specific survival, and financial toxicity. The study will also assess patient preferences for treatment outcomes. Statistical analyses will employ targeted maximum likelihood estimation (TMLE) to address treatment selection bias and confounding by indication. Discussion The CISTO Study is powered to detect clinically important differences in QOL and cancer-specific survival between the two treatment approaches. By including a diverse patient population, the study also aims to assess outcomes across the following patient characteristics: age, gender, race, burden of comorbid health conditions, cancer severity, caregiver status, social determinants of health, and rurality. Treatment outcomes may also vary by patient preferences, health literacy, and baseline QOL. The CISTO Study will fill a crucial evidence gap in the management of recurrent high-grade NMIBC, providing evidence-based guidance for patients and clinicians in choosing between BST and radical cystectomy. The CISTO study will provide an evidence-based approach to identifying the right treatment for the right patient at the right time in the challenging clinical setting of recurrent high-grade NMIBC. Trial registration ClinicalTrials.gov, NCT03933826. Registered on May 1, 2019.

En 1999, le ministère français chargé de l'environnement a lancé un inventaire national des digues de protection contre les inondations, à l'appui d'un outil logiciel : la base de données " DIGUES ". Les crues dramatiques de septembre 2002 dans le Gard viennent de confirmer toute l'importance de cette opération de recensement qui vise à évaluer les enjeux de sécurité liés aux digues. Après avoir rappelé les principales caractéristiques de l'opération, le présent article dresse son état d'avancement et les premières extrapolations qui peuvent être faites, expose en détail les résultats obtenus pour les digues de la région Aquitaine, et enfin décrit les perspectives de poursuite du recensement. À la fin de l'année 2002, le recensement est achevé pour quatre régions administratives (Alsace, Aquitaine, Haute-Normandie et Nord Pas-de-Calais). Une extrapolation grossière des résultats permet de dégager des premiers ordres de grandeur concernant le parc national de digues (entre 7 500 et 12 000 km d'ouvrages), et confirme la spectaculaire dispersion des gestionnaires, qui seraient de l'ordre du millier. Choisie comme exemple, la région Aquitaine compte quelque 840 km de digues, réparties, pour l'essentiel, entre la Garonne, l'estuaire de la Gironde, la Dordogne et l'Adour. Plus des deux tiers de ces digues soulèvent des préoccupations, souvent parce que leur état réel est inconnu ou que leur gestionnaire n'est pas identifié. Une nouvelle version - accessible via le réseau Internet - de la base de données DIGUES est en cours de diffusion. Ceci devrait permettre de terminer le recensement des ouvrages dans les meilleures conditions, en vue d'identifier les digues qui nécessitent les travaux de confortement les plus urgents.

Aim: Social isolation in cancer patients is correlated with prognosis and is a potential mediator of treatment completion. Black women with endometrial cancer (EC) are at increased risk for social isolation when compared with White patients. We developed the Social Interventions for Support during Treatment for Endometrial Cancer and Recurrence (SISTER) study to compare and evaluate interventions to address social isolation among Black women with high-risk EC in USA. The primary objective of the SISTER study is to determine whether virtual support interventions improve treatment completion compared with Enhanced Usual Care. Secondary objectives include comparing effectiveness virtual evidence-based interventions and evaluating barriers and facilitators to social support delivery. Patients & methods: This is a multi-site prospective, open-label, community-engaged randomized controlled trial, consisting of three intervention arms: enhanced usual care, facilitated support group and one-to-one peer support. Primary outcome will be measured using relative dose. Qualitative semi-structured interviews will be conducted with a subset of participants to contextualize the relative degree or lack thereof of social isolation, over time. Data analysis: Primary analysis will be based on an intent-to-treat analysis. Multivariable analysis will be performed to determine the effect of the intervention on the primary and secondary outcomes of interest, relative dose and social isolation score. Semi-structured interviews will be qualitatively analyzed using inductive and deductive approaches of content analysis. Discussion/conclusion: Endometrial cancer mortality disproportionately affects Black women, and social isolation contributes to this disparity. The SISTER study aims to identify whether and to what extent differing social support vehicles improve key outcomes for Black women in the United States with high-risk EC.

The activity level and specific behaviours exhibited by captive animals are crucial indicators of welfare. Stereotypies, or repetitive behaviours that have no apparent function or goal, are performed by animals experiencing poor conditions in their environment and indicate welfare concerns. Changes in the housing environment in particular may have critical influences on behaviour and welfare. Here, we measured behavioural changes in a captive pinyon jay (Gymnorhinus cyanocephalus) population (n = 10) associated with a shift from single to pair housing. Using automated video processing, we show that pair housing greatly reduced overall activity levels in these birds. The stark reduction in activity was surprising, as we expected that social housing would increase interactions between birds, thus increasing activity levels. Upon further analysis, however, we found that stereotypic behaviours, such as beak scraping, jumping, pecking, and route tracing decreased after pair housing, whereas the positive welfare behaviours of perching and preening increased. Our results indicate that pair housing may reduce overall activity in pinyon jays; however, this reduction is primarily in stereotypic behaviours.

Summary: Background: Quitting smoking is especially challenging for low-income smokers due to high stress, high smoking prevalence around them, and limited support for quitting. This study aimed to determine whether any of three interventions designed specifically for low-income smokers would be more effective than standard tobacco quitline services: a specialized quitline, the specialized quitline with social needs navigation, or the standard quitline with social needs navigation. Methods: Using a randomized 2 × 2 factorial design, low-income daily cigarette smokers (n = 1944) in Missouri, USA who called a helpline seeking assistance with food, rent or other social needs were assigned to receive Standard Quitline alone (n = 485), Standard Quitline + Social Needs Navigation (n = 484), Specialized Quitline alone (n = 485), or Specialized Quitline + Social Needs Navigation (n = 490). The target sample size was 2000, 500 per group. The main outcome was 7-day self-reported point prevalence abstinence at 6-month follow-up. Multiple imputation was used to impute outcomes for those missing data at 6-month follow-up. Binary logistic regression analyses were used to assess differences between study groups. Findings: Participants were recruited from June 2017 to November 2020; most were African American (1111 [58%]) or White (666 [35%]), female (1396 [72%]), and reported

In modern oncology, therapies are based on combining monotherapies to overcome treatment resistance and increase therapy precision. The application of microsecond-pulsed electric fields (PEF) is approved to enhance local chemotherapeutic drug uptake within combination electrochemotherapy regimens. Reactive oxygen species (ROS) have been implicated in anticancer effects, and cold physical plasma produces vast amounts of ROS, which have recently been shown to benefit head and neck cancer patients. PEF and cold plasma technology have been linked to immunogenic cell death (ICD) induction, a regulated cell death accompanied by sterile inflammation that promotes antitumor immunity. To this end, we investigated the combined effect of both treatments regarding their intracellular ROS accumulation, toxicity, ICD-related marker expression, and optimal exposure sequence in a leukemia model cell line. The combination treatment substantially increased ROS and intracellular glutathione levels, leading to additive cytotoxic effects accompanied by a significantly increased expression of ICD markers, such as the eat-me signal calreticulin (CRT). Preconditioned treatment with cold plasma followed by PEF exposure was the most potent treatment sequence. The results indicate additive effects of cold plasma and PEF, motivating further studies in skin and breast tumor models for the future improvement of ECT in such patients.