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Resumen Objetivos Valorar, mediante resonancia magnetica (RM), las caracteristicas morfocineticas, farmacocineticas y de difusion de las neoplasias de mama con fenotipo triple negativo y analizar si hay relacion entre estos parametros y el tiempo hasta la progresion. Material y metodos Estudio retrospectivo y observacional de una serie consecutiva de 100 pacientes con diagnostico histologico de cancer de mama, fenotipo triple negativo, entre enero de 2005 y diciembre de 2010 en nuestro centro. Se revisaron los estudios de RM de extension locorregional y se recogieron las caracteristicas anatomopatologicas y el seguimiento de las pacientes hasta agosto de 2014. Resultados Las caracteristicas mas frecuentes por RM de estos tumores fueron: lesiones tipo masa de morfologia redondeada (47,3%), bordes bien delimitados (53,7%), patron de captacion “en anillo” (46,2%), curvas de tipo 3 (50,5%), hiperintensidad de senal intratumoral en las secuencias potenciadas en T2, valores altos de ADC (coeficiente de difusion aparente) (1,04 × 10 −3 mm 2 /s) y una permeabilidad capilar aumentada (Kep) (0,94 min −1 ). No se evidencio ninguna relacion estadisticamente significativa entre las caracteristicas morfocineticas o farmacocineticas y el tiempo hasta la progresion. Se hallo elevada presencia del componente in situ en las piezas quirurgicas, aunque su representacion era baja. En el seguimiento, un 25% presentaron metastasis, con predileccion por organos viscerales y baja supervivencia. Conclusion Las neoplasias con fenotipo triple negativo mostraron mayoritariamente en la RM lesiones de tipo masa, de morfologia redondeada, bordes bien delimitados y patron de captacion “en anillo”. No se evidencio ninguna relacion estadisticamente significativa entre las caracteristicas morfocineticas o farmacocineticas y el tiempo hasta la progresion.

Objectives To evaluate the morphokinetic, pharmacokinetic, and diffusion characteristics of triple-negative breast cancers on magnetic resonance (MR) imaging and to analyze whether there is a relation between these parameters and the time to progression. Material and methods This was a retrospective observational study of a consecutive series of 100 patients with histologically confirmed triple-negative breast cancer studied at our center between January 2005 and December 2010. We reviewed the findings on MR locoregional extension studies, the histological findings, and the follow-up of patients until August 2014. Results The most common MR findings for these tumors were a rounded mass (47.3%), well-defined borders (53.7%), ring enhancement (46.2%), type 3 curves (50.5%), hyperintensity within the tumor on T2-weighted sequences, high ADC values (1.04 × 10 −3 mm 2 /s), and increased capillary permeability (Kep) (0.94 min −1 ). No significant association was observed between the morphokinetic or pharmacokinetic characteristics and the time to progression. The in situ component in the surgical specimens was high, although its expression was low. During follow-up, 25% of patients had metastases, with a predilection for the visceral organs, and survival was low. Conclusion Tumors with the triple-negative phenotype mostly presented in MR as rounded tumors with well-defined borders and ring enhancement. We found no significant association between the morphokinetic or pharmacokinetic characteristics and the time to progression.

To evaluate the morphokinetic, pharmacokinetic, and diffusion characteristics of triple-negative breast cancers on magnetic resonance (MR) imaging and to analyze whether there is a relation between these parameters and the time to progression.This was a retrospective observational study of a consecutive series of 100 patients with histologically confirmed triple-negative breast cancer studied at our center between January 2005 and December 2010. We reviewed the findings on MR locoregional extension studies, the histological findings, and the follow-up of patients until August 2014.The most common MR findings for these tumors were a rounded mass (47.3%), well-defined borders (53.7%), ring enhancement (46.2%), type 3 curves (50.5%), hyperintensity within the tumor on T2-weighted sequences, high ADC values (1.04 × 10(-3) mm2/s), and increased capillary permeability (Kep) (0.94 min(-1)). No significant association was observed between the morphokinetic or pharmacokinetic characteristics and the time to progression. The in situ component in the surgical specimens was high, although its expression was low. During follow-up, 25% of patients had metastases, with a predilection for the visceral organs, and survival was low.Tumors with the triple-negative phenotype mostly presented in MR as rounded tumors with well-defined borders and ring enhancement. We found no significant association between the morphokinetic or pharmacokinetic characteristics and the time to progression.