24 results on '"M. Vairo"'
Search Results
2. Cranio-axial chordomas. A 15-year clinico-pathological experience at the 'Casa Sollievo della Sofferenza' hospital
- Author
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M. Bisceglia, C. Clemente, M. Vairo, L. Di Candia, G. Giannatempo, M. Bianco, V. A. D'Angelo, PASQUINELLI, GIANANDREA, M. Bisceglia, C. Clemente, M. Vairo, L. Di Candia, G. Giannatempo, M. Bianco, V.A. D'Angelo, and G. Pasquinelli
- Published
- 2007
3. Lessons Learned by the Reporter: Is Disaggregation the Answer to the Asbestos Mess?
- Author
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Georgene M. Vairo
- Subjects
Engineering ,business.industry ,Bankruptcy ,Law ,Arbitration ,business ,Multidistrict litigation ,Settlement (litigation) ,Dispute resolution ,Class action ,Mass tort ,Supreme court - Abstract
Described as an “elephantine mass” that “defies customary judicial administration,” asbestos litigation remains the longest-running mass tort in U.S. history. Ultimately, the efforts made to resolve the ever-expanding asbestos litigation failed. In 1997, in Amchem Products, Inc. v. Windsor, the United States Supreme Court struck down the use of a class action settlement to achieve a global resolution of all asbestos claims — those pending at the time and those of future claimants. In the wake of Amchem, dozens of asbestos defendants sought bankruptcy protection while plaintiffs continued to file claims in state and federal courts. Between 1988 and 2010, a United States Government Accountability Office (GAO) analysis of the approximately 100 bankruptcy trusts’ payment data showed that the asbestos trusts had paid about $17.5 billion to 3.3 million claimants. Since then, much has happened but basic problems remain. The patchwork system of plaintiffs claiming in federal and state courts, as well as the separate administrative claiming before bankruptcy trusts, raises complicated issues about how injured persons can be properly compensated while assuring that defendants are not assessed damages that are not warranted, and how to protect the trusts from fraud and preserve trust funds for future meritorious claimants.The American Bar Association Torts and Insurance Section appointed a Task Force to look into issues currently confronting asbestos stakeholders. I was appointed its Reporter. This Article focuses on how the Task Force went about its work and developed a record. It then presents some thoughts on how my service brought together my long-standing academic interest in how mass torts ought to be resolved and the realities of the current asbestos litigation. What I have learned thus far has led me to question my once zealous advocacy of aggregated mass tort claims resolution.When I served as Chairperson of the Dalkon Shield Claimant’s Trust, I wrote articles that focused on how the Trust resolved hundreds of thousands of claims. It is fair to say that I was a fan of aggregate resolution of mass torts. In my view, the use of multidistrict litigation, class actions, other aggregation tools, and even Chapter 11 reorganization provided fair and efficient vehicles for the resolution of mass torts. Indeed, the Dalkon Shield Board of Trustees expressly adopted motivating principles as they began to put meat on the bones of the CRF. First, and foremost, among these principles, was to “[t]reat all claimants fairly and equally, always focusing on the best interests of claimants collectively instead of on the interests of a particular claimant or group of claimants.” Another principle harkened back to the first: “Prefer settlement and prompt payment of claims over arbitration and litigation.” Rereading these principles in light of the compelling testimony of two of the Task Force witnesses challenged my weltanschauung about mass tort dispute resolution. Judge Robreno’s and Judge Davidson’s testimony about disaggregating cases into their core components, “letting lawyers be lawyers,” and getting cases ready for trial instead of obsessing about global or individual settlements is what led to the successful resolution of the cases before them.Moreover, Judge Robreno’s testimony suggests that attempts at aggregated resolution of the “elephantine mass” were all failures, except for the MDL itself, which has largely wrapped up its work. Rather, as Judges Robreno and Davidson testified, the disaggregation of asbestos claims allowed asbestos cases to be prepared for trial (or settlement discussions) more expeditiously. Now, dying plaintiffs can get a shot at a prompt trial date rather than having to wait out a global settlement. Perhaps tending to the needs of particular plaintiffs is the best way to protect the interests of the whole in mass tort litigation after all.
- Published
- 2014
- Full Text
- View/download PDF
4. Effect of geometry and mass distribution on tumbling characteristics of flying wings
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C. M. Fremaux, D. M. Vairo, and R. D. Whipple
- Subjects
Engineering ,business.product_category ,Aspect ratio (aeronautics) ,Computer simulation ,Mass distribution ,Angle of attack ,business.industry ,Longitudinal static stability ,Aerospace Engineering ,Mechanics ,Airplane ,Autorotation ,Model test ,business ,Simulation - Abstract
Results from an investigation to determine the low-speed tumbling characteristics of 12 generic fly ing-wing models are summarized. There is some concern that airplanes with fly ing-wing planforms could inadvertently enter an out-of-contro l tumbling motion under certain conditions. The objectives of this investigation were to 1) identify the geometric and mass-related parameters that cause flying wings to be capable of sustained tumbling and 2) analyze some of the driving mechanisms that cause steady tumbling. Free-tumble and free-to-pitch tests were conducted with dynamically scaled, generic flying-wing models. Results indicated that e.g. location, mass distribution, and geometric aspect ratio strongly affected the tumbling characteristics of the models tested and that positive static stability did not necessarily preclude tumbling. The magnitude of dynamic effects were found to be of the same order as static effects for the models undergoing autorotation-in-pitch.
- Published
- 1995
- Full Text
- View/download PDF
5. Persistence of the cultural landscape in Campania (Southern Italy) before the AD 472 Vesuvius eruption: archaeoenvironmental data
- Author
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Alessandra Pecci, M. Vairo, Masanori Aoyagi, G. Di Pasquale, G. F. De Simone, Mauro Paolo Buonincontri, Minoru Yoneda, C. Angelelli, Emilia Allevato, S. Matsuyama, Kazuhiko Takeuchi, M.A. Cau, Allevato, Emilia, Buonincontri, Mauro Paolo, Vairo, M., Pecci, A., Cau, M. A., Yoneda, M., De Simone, G. F., Aoyagi, M., Angelelli, C., Matsuyama, S., Takeuchi, K., and DI PASQUALE, Gaetano
- Subjects
Archeology ,Geography ,Agriculture ,business.industry ,Charcoal analysis, Residue analysis, AMS radiocarbon dating, Wine, 5th century, Timber ,Cultural landscape ,Period (geology) ,Woodland ,Integrated approach ,business ,Archaeology ,Silviculture - Abstract
Cultural landscapes were prominent during the Early Roman period when agronomic knowledge allowed the spread of intensive land exploitation in most of the available land. The aim of this contribution is to explore whether for the Campania region (Southern Italy) archaeoenvironmental data would support continuity or change in the cultural landscape of Roman tradition in the 4th and 5th centuries. To do so, new data from two sites located on the northern slopes of the Vesuvius, both buried by the AD 472 eruption have been investigated. Charcoal analysis, 14 C dating, and chemical analysis of organic residues were carried out in order to study the landscape and the food production at these sites. The results suggest the persistence of the Roman cultural landscape until the 4th and 5th centuries in this area. The landscape is in fact strongly marked both in agriculture and woodland exploitation and management, being characterized by managed chestnut forests as well as valuable cultivations of walnut, large vineyards, olive groves, and probably orchards and crops. The integrated approach with archaeobotanical and archaeometric analyses proves to be a powerful method for the study of the past landscapes, providing a good insight into the environment. Furthermore, this study provided the most ancient evidence of chestnut silviculture for wood.
- Published
- 2012
6. Mass Torts Bankruptcies: The Who, the Why, and the How
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Georgene M. Vairo
- Subjects
Consolidation (business) ,Bankruptcy ,Law ,Economics ,Personal injury ,Corporation ,Mass tort ,Supreme court - Abstract
For the last several decades, federal and state courts, with varying degrees of cooperation from the parties and lawyers involved, have developed ways of managing the complex mass tort cases confronting them. A key development was the emergence of the idea of using consolidation techniques to achieve global peace in the resolution of these often seemingly intractable cases. In the wake of the Supreme Court's decisions in Amchem and Ortiz, however, the use of class actions to achieve global peace became problematic. Meanwhile, Chapter 11 proceedings under the bankruptcy laws emerged as a vehicle for achieving global peace. Especially after Amchem, it appears that the use of Chapter 11, despite the problems raised for a defendant corporation, may be the best tool for achieving global peace. This working paper provides a brief history of the three leading mass tort bankruptcy cases: the Johns Manville Chapter 11 case involving asbestos personal injury claims, the A.H. Robins Chapter 11 case involving Dalkon Shield claims, and the Dow Corning Chapter 11 case involving breast implant claims. The purpose of the review of these cases is to highlight the important practical and doctrinal issues raised by the use of Chapter 11 as a vehicle for resolving mass tort litigation.
- Published
- 2003
- Full Text
- View/download PDF
7. Remedies for Victims of Terrorism
- Author
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Georgene M. Vairo
- Subjects
Jurisdiction ,Law ,Economics ,Legislature ,Legislation ,Federalism ,Tort ,Class action ,Mass tort ,Supreme court - Abstract
The September 11 attack on the World Trade Tower and the Pentagon left thousands of victims in its wake. Seemingly quite laudably, Congress almost immediately enacted a bill that set up a Victim's Compensation Fund ("VCF") that held out the potential for quickly and reasonably compensating those injured in the disaster as well as the families of those who were killed. This paper describes the VCF, and discusses some of the problems that the Special Master of the VCF confronted while preparing the rules for how the victims would be compensated. This discussion then leads into the much larger question of the extent to which Congress ought to be involved in the resolution of personal injury and other state based claims. Traditionally, of course, our legal system generally has left the resolution of personal injury claims to state law. Additionally, the vast majority, at least until the rise of mass tort litigation, of such cases were resolved in state courts. It would seem that United States Supreme Court's recent federalism cases would support federal abstinence in this area. To the contrary, Congress, generally led by Republicans, have enacted and proposed legislation that have the effect of stripping state courts of their traditional role in the resolution of tort and other state law based cases. Thus, the paper raises the question whether the VCF is the camel's nose under the tent. It is notable that at the same time that Congress created the VCF, it also provided a massive bailout for the airline industry. Is the legislative climate such that we can expect future enactment of legislation providing, for example, compensation for victims of exposure to asbestos, while limiting the liability of the corporations and entities involved in the ever-expanding asbestos litigation? What are the federalism implications of bills like the Class Action Fairness Act that would allow defendants to remove virtually any class action from state court to federal court? The paper concludes that the ought to be a reasonable balance. There always has been concurrent federal and state jurisdiction over a large number of cases. As a practical matter, when complex litigation of a national scope threatens the ability of the state and federal court's ability to provide reasonable compensation within a reasonable time frame, the federal courts should play an important role, and Congress ought to provide the courts with the tools necessary to resolve the litigation and achieve global peace if possible. Nonetheless, it is important to consider that federal resolution, whether in federal courts or some administrative scheme like the VCF, violates important principles of federalism, and therefore ought not become the general rule. For example, given the intractability of the asbestos litigation and the numerous bankruptcies it has spawned, it may well be appropriate for Congress to enact appropriate legislation. The VCF is a response to a disaster, though localized, that is national in nature. On the other hand, bills like the Class Action Fairness Act are suspect because they simply evidence distrust of state courts' ability to fairly resolve cases.
- Published
- 2002
- Full Text
- View/download PDF
8. [Pigmented fibrosarcomatous dermatofibrosarcoma protuberans (Bednar tumor). 3 case reports, analogy with the 'conventional' type and review of the literature]
- Author
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M, Bisceglia, M, Vairo, E, Calonje, and C D, Fletcher
- Subjects
Adult ,Male ,Fatal Outcome ,Skin Neoplasms ,Dermatofibrosarcoma ,Humans ,Skin Pigmentation ,Neoplasm Metastasis ,Neoplasm Recurrence, Local ,Aged - Abstract
The so-called Bednar tumor represents a pigmented variant of dermatofibrosarcoma protuberans (DFSP) and is characterized by a usually scant (1-5% of cells) population of dendritic melanocytes within an otherwise typical DFSP. This pigmented variant accounts for up to 5% of all DFSPs. Other variants of DFSP include cases showing features (in the primary or recurrence) of either giant cell fibroblastoma or fibrosarcoma. Less than 5% of DFSPs are associated with metastases and many of these show either a fibrosarcomatous component or, much more rarely, an "MFH"-like appearance. Only one previous case has been reported which showed combined features of the pigmented and fibrosarcomatous variants.We present herein 3 cases of fibrosarcomatous Bednar tumor, all occurring in males, 2 aged 75 and 1 aged 23; two patients were white and one black. The tumors were located on the trunk or shoulder and two had been present for many years with recent rapid growth. One patient developed local recurrence and metastases to bone and lung and died within 1 year. The other two patients are disease free at 3 and 5 years follow-up respectively. All three cases showed typical histological features and in two tumors the pigment was evident macroscopically.A through literature review, including all cases of fibrosarcomatous DFSP and metastasizing fibrosarcomatous DFSP (whether or not pigmented), confirms that the fibrosarcomatous variant of DFSP (including its pigmented counterpart) is significantly more aggressive than usual DFSP, thus underlining the importance of its accurate recognition.
- Published
- 1997
9. VR Queries and their Transformations in a Progressive Querying Environment
- Author
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Maria Francesca Costabile, Shi-Kuo Chang, and M. Vairo
- Subjects
Sequence ,Information retrieval ,Computer science ,InformationSystems_INFORMATIONSTORAGEANDRETRIEVAL ,InformationSystems_DATABASEMANAGEMENT ,Virtual reality ,Space (commercial competition) ,Formal description - Abstract
We have proposed a progressive querying environment that enables the user to interact with the database by a sequence of partial queries, and to visualize both database queries and retrieval results in many different representations. In our approach, the user can query the database in the Virtual Reality (VR) space, and then switch to the logical space to continue the formulation of the query. This paper provides a formal definition and characterization of VR queries, describes what database operators are applicable under the different interaction paradigms, and investigates how VR queries can be transformed into other types of queries, so that they can be utilized as part of a progressive querying system.
- Published
- 1996
- Full Text
- View/download PDF
10. [Techniques for the diagnosis of kidney diseases. Is there a role for the immunoperoxidase method in the evaluation of immunologic glomerulopathy on biopsy specimens, including those in paraffin? Our experience: preliminary results]
- Author
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M, Bisceglia, N, De Luca, F, Scaramuzzi, M, Vairo, L, Zaffarano, and M, D'Errico
- Subjects
Immunoenzyme Techniques ,Biopsy ,Humans ,Immune Complex Diseases ,Immunoglobulins ,Kidney Diseases ,Kidney ,Biomarkers - Abstract
Firstly an extensive summary of the diagnostic power and limits in renal glomerular pathology of light microscopy even corroborated by all the special histochemical stains is made. Secondly a complete list of all those renal glomerular diseases in which electron microscopy is unanimously considered necessary for the diagnosis is given as well as the main and most updated references pertinent to those rare and recently recognized pathological entities in which EM proved as a fundamental diagnostic tool are provided. Thirdly the authors focus on the importance of immunohistochemistry (IIC) in the diagnosis of immune-mediated renal glomerular diseases. The advantages and disadvantages of immunofluorescence microscopy (IF) and immunoperoxidase method (I-perox) are respectively discussed. The value of I-perox staining method applied to sections from paraffin blocks is emphasized and some technical suggestions in order to optimize results are given. Among the latter the choice of the used fixative for the purpose of preserving antigenicity of immunoglobulins and complement fractions, the timing of tissue fixation as well as the quantitation of enzymatic pretreatment relative to the duration of fixation, and the repeated washings with phosphate-buffer saline to minimize background staining. Ultimately the authors report on their preliminary personal results with the use of I-perox staining on sections from paraffin embedded renal core biopsies. Although if is their favourite diagnostic microscopy for evaluating renal immunopathology the authors underline I-perox method as a helpful tool to rely on at least in those circumstances when frozen material for IF is not available due to the scarcity of core biopsy, when glomeruli are absent in frozen sections, or when due to a technical lab accident the frozen tissue devoted to IF has been ruined or lost, and the only available material is the one which lies embedded in paraffin. The LSAB ("labelled streptavidin biotin") complex and PAP ("peroxidase-antiperoxidase") working procedures are provided in detail.
- Published
- 1995
11. Effect of geometry, static stability, and mass distribution on the tumbling characteristics of generic flying-wing models
- Author
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D. M. Vairo, R. D. Whipple, and C. M. Fremaux
- Subjects
Aerodynamic force ,Physics ,Center of gravity ,Wing ,Mass distribution ,Control theory ,Degrees of freedom (statistics) ,Longitudinal static stability ,Equations of motion ,Stability derivatives - Abstract
Results from an investigation to determine the low-speed tumbling characteristics of twelve generic flying-wing models are summarized. There is a concern that airplanes with flying-wing planforms could inadvertently enter an out-of-control tumbling motion under certain conditions. The objectives of this investigation were to: 1) identify the geometric and mass-related parameters that cause flying wings to be capable of sustained tumbling, 2) analyze some of the driving mechanisms that cause tumbling, and 3) determine the feasibility of using computer simulations to predict the tumbling characteristics of flying wings. Free-tumble and free-to-pitch tests were conducted with dynamically-scaled, generic flying wing models. The use of computer simulations as a predictive tool for tumbling was explored. Results indicated that center-of-gravity location, mass distribution, and geometric aspect ratio strongly affected the tumbling characteristics of the models tested and that positive static stability did not necessarily preclude tumbling. The magnitude of dynamic effects were found to be of the same order as static effects for the models undergoing autorotation-in-pitch. The simulations indicated that the dynamic terms in the equations of motion used to predict tumbling must be obtained using experimental methods that account for the large amplitude/high pitch-rate environment that characterizes tumbling.
- Published
- 1993
- Full Text
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12. International Territorial Restrictions Through Patents Under United States Law
- Author
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Georgene M. Vairo and Barry E. Hawk
- Subjects
Economics and Econometrics ,Law - Published
- 1980
- Full Text
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13. [The cord blood lipid profile and electrophoretic lipidogram]
- Author
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N, Nigro, M, Brunet, M, Baltieri, A, Martini, T, Ferrando, and M, Vairo
- Subjects
Cholesterol ,Lipoproteins ,Infant, Newborn ,Humans ,Fatty Acids, Nonesterified ,Blood Protein Electrophoresis ,Fetal Blood ,Lipids ,Infant, Newborn, Diseases ,Phospholipids ,Triglycerides - Published
- 1977
14. Paratesticular mesothelioma. Report of a case with comprehensive review of literature
- Author
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Matteo Vairo, Illuminato Carosi, David Ben Dor, Gianandrea Pasquinelli, Michele Bisceglia, M. Bisceglia, DB. Dor, I. Carosi, M. Vairo, and G. Pasquinelli.
- Subjects
Male ,Mesothelioma ,Pathology ,medicine.medical_specialty ,Multicystic Mesothelioma ,medicine.disease_cause ,Asbestos ,Spermatic cord ,MESOTHELIOMA/PATHOLOGY ,Pathology and Forensic Medicine ,Testicular Neoplasms ,Hydrocele ,medicine ,Humans ,Aged ,business.industry ,Tunica vaginalis ,medicine.disease ,Serous fluid ,medicine.anatomical_structure ,Lymphatic Metastasis ,Anatomy ,Differential diagnosis ,Neoplasm Recurrence, Local ,business - Abstract
Paratesticular mesotheliomas are rare tumors with 223 cases described so far. The sole plausible causative factor so far ascertained in the pathogenesis of these tumors is asbestos, which however is found in only around 30% to 40% of such cases. The age range of affected individuals is wide, mostly adults and the elderly, but also includes young people and children. The most common presenting symptom is either hydrocele of unknown origin or intrascrotal mass. When hydrocele is the presenting symptom, these tumors are often clinically overlooked and the diagnosis is delayed. Most paratesticular mesotheliomas arise in the tunica vaginalis, but primary tumors of the spermatic cord and epididymis are also on record. Tumors arising from the peritoneal mesothelium of a hernia sac are excluded from this group. The correct diagnosis is almost always made after histologic examination of the operative specimen. Immunohistochemistry and electron microscopy are always helpful and sometimes necessary tools for diagnosis. So far very few cases have been identified or suspected preoperatively on cytologic examination. Three clinicopathologic types of malignant mesotheliomas of the male genital tract are recognized: diffuse tubulo-papillary mesothelioma, well-differentiated papillary mesothelioma, and multicystic mesothelioma. The histologic subtypes are almost always pure epithelial or biphasic. The differential diagnosis is mainly with serous papillary tumors arising from Mullerian vestiges, but several diverse primary or secondary tumors also need to be considered. A clinicopathologic evaluation of a case of tunical diffuse mesothelioma in a 74-year-old male from the AMR Series is the starting point for this general review.
- Published
- 2009
15. Handling and standardization of EBUS needle aspiration in NSCLC patients: The value of the cell block, a monoinstitutional experience.
- Author
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Parente P, Carbonelli C, Biancofiore G, Sukthi A, Di Micco CM, Vairo M, Fuso P, Taurchini M, and Graziano P
- Subjects
- B7-H1 Antigen metabolism, Bronchoscopy methods, Endoscopic Ultrasound-Guided Fine Needle Aspiration methods, Humans, Neoplasm Staging, Protein-Tyrosine Kinases, Proto-Oncogene Proteins, Receptor Protein-Tyrosine Kinases, Reference Standards, Retrospective Studies, Carcinoma, Non-Small-Cell Lung pathology, Lung Neoplasms pathology
- Abstract
Background: Lung cancer is the main cause of cancer-related death worldwide, and 85% of all lung tumors are non-small cell lung cancers (NSCLC). More than 60% of all lung tumors are diagnosed at an advanced stage, leading to poor prognosis. Given the growing demand for NSCLC profiling for selection of the most appropriate therapy, the acquisition of adequate tumor samples has become increasingly crucial, mostly in advanced NSCLC patients due to old age and/or comorbidities. Being a mini-invasive sampling technique, endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) represents a valuable alternative to traditional transthoracic or surgical sampling in these patients, and perfoming cell block (CB) could be crucial to maximize the potential biological information. The aim of this study is to describe a monoinstitutional interprofessional experience in handling EBUS-TBNA and CB in 464 patients., Methods: We retrospectively collected all the consecutive CBs obtained from EBUS TBNA performed between 2014 and 2021 on the lung lesions or mediastinal lymph nodes. All the CBs were handled in a standardized method., Results: A total of 95.5% (448/464 samples) of adequacy for site and 92.6% (430/464) of adequacy for diagnosis were observed. Moreover, in the adenocarcinoma histotype, ALK, ROS1 and tumor proportion score (TPS) PD-L1 assessment by IHC was possible in 96% (140/146) of cases, and molecular profile was obtained in 93.8% (137/146) of cases. In the squamous cell carcinoma histotype, TPS PD-L1 assessment was possible in 81% (13/16) of cases. All four CB results obtained from carcinoma NOS were adequate for ALK, ROS1 and PD-L1 assessment and molecular profiling. All 39 metastatic samples from extra-pulmonary primary were adequate for immunohistochemical characterization and molecular profiling. Finally, reporting of the tumor sample adequacy to the clinicians took a median time of about 30 h (range: 24-80 h)., Conclusion: Careful cytological smear management together with the handling and standardization of CB obtained from EBUS-TBNA could represent an effective method to increase the adequacy of the tumor specimen for both diagnosis and molecular profile., (© 2022 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd.)
- Published
- 2022
- Full Text
- View/download PDF
16. Paratesticular mesothelioma. Report of a case with comprehensive review of literature.
- Author
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Bisceglia M, Dor DB, Carosi I, Vairo M, and Pasquinelli G
- Subjects
- Aged, Humans, Lymphatic Metastasis, Male, Neoplasm Recurrence, Local pathology, Mesothelioma pathology, Testicular Neoplasms pathology
- Abstract
Paratesticular mesotheliomas are rare tumors with 223 cases described so far. The sole plausible causative factor so far ascertained in the pathogenesis of these tumors is asbestos, which however is found in only around 30% to 40% of such cases. The age range of affected individuals is wide, mostly adults and the elderly, but also includes young people and children. The most common presenting symptom is either hydrocele of unknown origin or intrascrotal mass. When hydrocele is the presenting symptom, these tumors are often clinically overlooked and the diagnosis is delayed. Most paratesticular mesotheliomas arise in the tunica vaginalis, but primary tumors of the spermatic cord and epididymis are also on record. Tumors arising from the peritoneal mesothelium of a hernia sac are excluded from this group. The correct diagnosis is almost always made after histologic examination of the operative specimen. Immunohistochemistry and electron microscopy are always helpful and sometimes necessary tools for diagnosis. So far very few cases have been identified or suspected preoperatively on cytologic examination. Three clinicopathologic types of malignant mesotheliomas of the male genital tract are recognized: diffuse tubulo-papillary mesothelioma, well-differentiated papillary mesothelioma, and multicystic mesothelioma. The histologic subtypes are almost always pure epithelial or biphasic. The differential diagnosis is mainly with serous papillary tumors arising from Mullerian vestiges, but several diverse primary or secondary tumors also need to be considered. A clinicopathologic evaluation of a case of tunical diffuse mesothelioma in a 74-year-old male from the AMR Series is the starting point for this general review.
- Published
- 2010
- Full Text
- View/download PDF
17. [Educational needs of sterilization central area. A case study].
- Author
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Primi G, Vario M, and Montagna L
- Subjects
- Adult, Attitude of Health Personnel, Educational Status, Female, Humans, Male, Health Services Needs and Demand, Hospital Departments, Professional Competence, Sterilization
- Abstract
Sterilization process requires to be performed by well-trained experts: this necessity is confirmed by so common cases of infection related to gaps into medical tools sterilization process. In many cases the process including all the steps from employment of sterile tools to reconditioning and re-usage is quite unknown and this lack of knowledge may be the cause of sensitive issues and mistakes. The case study is performed by a 15 questions test with a multiple answers system. The test has been given to be filled to nursing professionals and students. The scope of the research is to evaluate the grade of knowledge in the process of sterilization of one-use surgical tools. Results of this investigation display good chances of improvement either in the culture than in the procedure of such a sensitive aspect of medical care.
- Published
- 2007
18. [Therapeutic community model in short psychiatric hospitalization. Descriptive study on the dynamic psychiatric inpatient unit of the Italian hospital of Buenos Aires].
- Author
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Matusevich D, Ruiz M, Vairo M, Girard P, Rozadilla G, Castagnola G, Job A, Pinto I, and Finkelsztein C
- Subjects
- Argentina, Cross-Sectional Studies, Hospital Units, Humans, Models, Theoretical, Prospective Studies, Hospitalization statistics & numerical data, Length of Stay statistics & numerical data, Mental Disorders therapy, Psychiatric Department, Hospital statistics & numerical data
- Abstract
Objective: the aim of this paper is to communicate a project of short term psychiatric hospitalization, based on a therapeutic community model, considering qualitative and quantitative aspects in the present socio - cultural context., Introduction: this psychiatric hospitalization model that embraces psychodynamic and pharmacological interventions is focused in the intensity of interactions between members of the therapeutic community and integrated to the administrative structure of a general hospital; this will be the key to consider patient's return to the community and to move forward over the prejudices that inpatients suffer., Material and Methods: quantitative, prospective, observational and transversal study on a Dynamic Psychiatric Inpatient Unit. 605 patients were included., Results: mean length of stay was 16.34 days; principal causes of admission were depression (19.4%), suicide ideas (17.7%), suicide attempt (17.6%), substance abuse or dependence (14.3%), psychosis (13.8%), behavioral and psychological symptoms of dementia (6%). There were 75 readmissions. 14.88% patients were physically restrained. Principal Axis I diagnosis were depression (32.1%), substance dependence (13.2%), bipolar disorder (10.2%), dementia (7.6%), schizophrenia (7.5%), and psychotic disorder (5.8). Axis II diagnosis were borderline personality disorder (27.3%), narcissistic personality disorder (8.9%), histrionic personality disorder (5.3%)., Discussion: this kind of approach shows a structural model that allows possible and persistent favorable changes for psychiatric inpatients.
- Published
- 2006
19. Congenital mesoblastic nephroma: report of a Case with review of the most significant literature.
- Author
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Bisceglia M, Carosi I, Vairo M, Zaffarano L, Bisceglia M, and Creti G
- Subjects
- Biomarkers, Tumor analysis, DNA, Neoplasm analysis, Diploidy, Female, Flow Cytometry, Humans, Immunohistochemistry, Infant, Newborn, Kidney Neoplasms chemistry, Kidney Neoplasms pathology, Kidney Neoplasms surgery, Mitotic Index, Nephroma, Mesoblastic chemistry, Nephroma, Mesoblastic pathology, Nephroma, Mesoblastic surgery, Treatment Outcome, Kidney Neoplasms congenital, Nephroma, Mesoblastic congenital
- Abstract
Aims and Background: Congenital mesoblastic nephroma (CMN) is a rare pediatric tumor of the kidney with the highest peak of incidence during the first 3 postnatal months. It has previously been confused with Wilms' tumor (which, on the contrary, is rare during the first six months of age and is still considered a histogenetic congener). CMN almost always has a favourable prognosis. Therefore, CMN needs to be correctly diagnosed and differentiated from other pediatric renal neoplasms. Two morphological subtypes are currently distinguished histologically: the classical or leiomyomatous type and the atypical or cellular type. Mixed forms with a combination of the two patterns are also on record. Recurrence and even tumor-related death have been described in the literature and always related to the atypical form or to the mixed form, particularly in patients aged more than 3 months and in those cases in which the surgical removal was not complete. Opinions concerning post-surgical clinical management, especially in regard to adjuvant therapy, are not unanimous., Methods: A case of CMN, predominantly of the classical histological subtype diagnosed in a baby with a follow-up of 6 years, is herein presented. The tumor was discovered at birth and surgically removed after one month. Since the tumor showed a high mitotic index (one of the characteristics of the cellular subtype) and the perirenal fat was focally involved with the tumor, the possibility of giving adjuvant chemotherapy was considered. Flow cytometric analysis was also performed which showed a diploid DNA content of neoplastic cells., Results: The tumor was completely removed, surgical margins were free histologically, and no clear-cut histological features of the atypical subtype were noted. Flow cytometrically, it showed the euploid DNA content. Consequently no additional therapy was given. Six years after surgery the patient is developing well and is free of disease. He has regular follow-up examinations., Conclusions: CMN almost always pursues a benign clinical course if diagnosed under three months of age and if totally surgically excised independent of histological type. Criteria for management of atypical cases are not unanimous in regard to the benefit of additional therapy after surgery.
- Published
- 2000
- Full Text
- View/download PDF
20. ["Hyaline-cell chondroid syringoma." Morphological, immunohistochemical and ultrastructural study of a case and review of the literature].
- Author
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Bisceglia M, Clemente CR, Vairo M, Cafaro A, and Pasquinelli G
- Subjects
- Adenoma, Pleomorphic chemistry, Adenoma, Pleomorphic diagnosis, Biomarkers, Tumor analysis, Diagnosis, Differential, Ear Diseases diagnosis, Ear Neoplasms chemistry, Ear Neoplasms diagnosis, Humans, Male, Middle Aged, Neoplasm Proteins analysis, Adenoma, Pleomorphic pathology, Ear Neoplasms pathology, Ear, External pathology
- Abstract
Chondroid syringoma represents the cutaneous counterpart of mixed tumor ("pleomorphic adenoma") of salivary glands, therefore it is also termed mixed tumor of the skin. The presence of hyaline cells in mixed tumors of salivary gland is a very well known event. Tumors mainly or exclusively composed of hyaline cells are termed myoepitheliomas of hyaline type, accordingly to their alleged myoepithelial origin. Scanty components of hyaline cells in chondroid syringomas of the skin have also been observed since more than a decade. However chondroid syringomas mainly or exclusively composed of hyaline cells have been reported only very recently. If the hyaline cells of chondroid syringomas are myoepithelial or epithelial in origin is still a matter of debate, we prefer to retain the descriptive label "hyaline cell-rich chondroid syringoma" as originally conceived by JA Ferrero and AG Nascimento the patronimic authors of the entity. A case of hyaline cell-rich chondroid syringoma is reported on in a white male patient aged 64, which occurred on the external ear of 1-year duration. This case was studied immunohistochemically and ultrastructurally. Both immunoprofile which included reactivity for vimentin, low molecular weight cytokeratins, S-100 protein, GFAP (focally), alfa-smooth actin and muscle-specific actin, and ultrastructural features including evidence of intermediate filaments (non-bundling filaments, tonofilaments), desmosomes, and thin filaments of actin type sustain a myoepithelial differentiation for hyaline cells of this tumor and site. The authors also remark the importance of being aware of this new entity during the diagnostic practice for avoiding misinterpretation. A list of condition to be taken into account in differential diagnosis is also given.
- Published
- 1997
21. [Pigmented fibrosarcomatous dermatofibrosarcoma protuberans (Bednar tumor). 3 case reports, analogy with the "conventional" type and review of the literature].
- Author
-
Bisceglia M, Vairo M, Calonje E, and Fletcher CD
- Subjects
- Adult, Aged, Dermatofibrosarcoma classification, Fatal Outcome, Humans, Male, Neoplasm Metastasis, Neoplasm Recurrence, Local, Skin Neoplasms classification, Skin Pigmentation, Dermatofibrosarcoma pathology, Skin Neoplasms pathology
- Abstract
Background: The so-called Bednar tumor represents a pigmented variant of dermatofibrosarcoma protuberans (DFSP) and is characterized by a usually scant (1-5% of cells) population of dendritic melanocytes within an otherwise typical DFSP. This pigmented variant accounts for up to 5% of all DFSPs. Other variants of DFSP include cases showing features (in the primary or recurrence) of either giant cell fibroblastoma or fibrosarcoma. Less than 5% of DFSPs are associated with metastases and many of these show either a fibrosarcomatous component or, much more rarely, an "MFH"-like appearance. Only one previous case has been reported which showed combined features of the pigmented and fibrosarcomatous variants., Materials: We present herein 3 cases of fibrosarcomatous Bednar tumor, all occurring in males, 2 aged 75 and 1 aged 23; two patients were white and one black. The tumors were located on the trunk or shoulder and two had been present for many years with recent rapid growth. One patient developed local recurrence and metastases to bone and lung and died within 1 year. The other two patients are disease free at 3 and 5 years follow-up respectively. All three cases showed typical histological features and in two tumors the pigment was evident macroscopically., Conclusions: A through literature review, including all cases of fibrosarcomatous DFSP and metastasizing fibrosarcomatous DFSP (whether or not pigmented), confirms that the fibrosarcomatous variant of DFSP (including its pigmented counterpart) is significantly more aggressive than usual DFSP, thus underlining the importance of its accurate recognition.
- Published
- 1997
22. [Techniques for the diagnosis of kidney diseases. Is there a role for the immunoperoxidase method in the evaluation of immunologic glomerulopathy on biopsy specimens, including those in paraffin? Our experience: preliminary results].
- Author
-
Bisceglia M, De Luca N, Scaramuzzi F, Vairo M, Zaffarano L, and D'Errico M
- Subjects
- Biomarkers, Biopsy, Humans, Immune Complex Diseases diagnosis, Immune Complex Diseases immunology, Immune Complex Diseases pathology, Immunoglobulins analysis, Kidney chemistry, Kidney Diseases immunology, Kidney Diseases pathology, Immunoenzyme Techniques, Kidney pathology, Kidney Diseases diagnosis
- Abstract
Firstly an extensive summary of the diagnostic power and limits in renal glomerular pathology of light microscopy even corroborated by all the special histochemical stains is made. Secondly a complete list of all those renal glomerular diseases in which electron microscopy is unanimously considered necessary for the diagnosis is given as well as the main and most updated references pertinent to those rare and recently recognized pathological entities in which EM proved as a fundamental diagnostic tool are provided. Thirdly the authors focus on the importance of immunohistochemistry (IIC) in the diagnosis of immune-mediated renal glomerular diseases. The advantages and disadvantages of immunofluorescence microscopy (IF) and immunoperoxidase method (I-perox) are respectively discussed. The value of I-perox staining method applied to sections from paraffin blocks is emphasized and some technical suggestions in order to optimize results are given. Among the latter the choice of the used fixative for the purpose of preserving antigenicity of immunoglobulins and complement fractions, the timing of tissue fixation as well as the quantitation of enzymatic pretreatment relative to the duration of fixation, and the repeated washings with phosphate-buffer saline to minimize background staining. Ultimately the authors report on their preliminary personal results with the use of I-perox staining on sections from paraffin embedded renal core biopsies. Although if is their favourite diagnostic microscopy for evaluating renal immunopathology the authors underline I-perox method as a helpful tool to rely on at least in those circumstances when frozen material for IF is not available due to the scarcity of core biopsy, when glomeruli are absent in frozen sections, or when due to a technical lab accident the frozen tissue devoted to IF has been ruined or lost, and the only available material is the one which lies embedded in paraffin. The LSAB ("labelled streptavidin biotin") complex and PAP ("peroxidase-antiperoxidase") working procedures are provided in detail.
- Published
- 1995
23. [Primary angiosarcoma of the thyroid. Presentation of a case (epithelioid type) and nosological problems].
- Author
-
Bisceglia M, Vairo M, Tardio G, Scaramuzzi G, and Zingrillo M
- Subjects
- Aged, Antigens, Differentiation, Myelomonocytic analysis, Carcinoma classification, Carcinoma pathology, Cell Adhesion Molecules analysis, Cell Differentiation, Endothelium chemistry, Endothelium pathology, Hemangiosarcoma chemistry, Hemangiosarcoma classification, Humans, Keratins analysis, Lectins analysis, Male, Platelet Endothelial Cell Adhesion Molecule-1, Thyroid Neoplasms chemistry, Thyroid Neoplasms classification, Vimentin analysis, von Willebrand Factor analysis, Biomarkers, Tumor analysis, Hemangiosarcoma pathology, Neoplasm Proteins analysis, Plant Lectins, Thyroid Neoplasms pathology
- Abstract
There is a great deal of confusion in the literature as to whether or not true angiosarcomas of the thyroid exist or whether these are all anaplastic carcinomas of the thyroid which have an angiosarcomatoid appearance. Due to the fact that undifferentiated carcinomas of this organ can strikingly resemble various sarcomas it is recommended that great care should be taken prior to qualify as an angiosarcoma a malignant thyroid tumor. A lot of viewpoints have been expressed so far in literature concerning this theme, and they can be summarized as follows. On one side and not admitting the existence of angiosarcoma in this location there are opinions which think of it as a "variant" of undifferentiated carcinoma (a pure carcinoma with a pseudovascular pattern or a carcinoma with an intermingled non-neoplastic reactive vascular component), or as a neoplasm in transition from epithelial to endothelial differentiation ("mesenchymal neometaplasia"), or as a carcinoma with aberrant expression of endothelial markers, or as a carcinoma with a non-specific uptake of endothelial antigens(e.g. from serum in case of F-VIII R-Ag positivity). On the other side there are opinions in favor of the existence of such an entity, based upon light microscopy features coupled with immunocytochemical results (endothelial antigens expression without or with cytokeratins expression) and with the possible support of electron microscopy. Anyway ultrastructural findings of specific markers (Weibel-Palade bodies, pericellular basal lamina, tight junctions, subplasmalemmal pinocytotic vesicles) according to some authors are not a prerequisite: so poorly differentiated neoplasma can fail to show those histogenetic markers.(ABSTRACT TRUNCATED AT 250 WORDS)
- Published
- 1995
24. [The cord blood lipid profile and electrophoretic lipidogram].
- Author
-
Nigro N, Brunet M, Baltieri M, Martini A, Ferrando T, and Vairo M
- Subjects
- Blood Protein Electrophoresis, Cholesterol blood, Fatty Acids, Nonesterified blood, Humans, Infant, Newborn, Diseases blood, Lipoproteins blood, Phospholipids blood, Triglycerides blood, Fetal Blood analysis, Infant, Newborn, Lipids blood
- Published
- 1977
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