23 results on '"M. Shkolnikova"'
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2. MYOTONIA
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D. Vlodavets, M. Shkolnikova, V. Bereznitskaya, Z. Romantsova, R. Ildarova, A. Monakhova, O. Shidlovskaya, I. Shulyakova, S. Artemieva, E. Litvinova, and E. Belousova
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Neurology ,Pediatrics, Perinatology and Child Health ,Neurology (clinical) ,Genetics (clinical) - Published
- 2019
3. Poster session 2
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J. M. Perez-Pomares, A. Ruiz-Villalba, A. Ziogas, J. C. Segovia, M. Ehrbar, R. Munoz-Chapuli, A. De La Rosa, J. N. Dominguez, L. Hove-Madsen, B. Sankova, D. Sedmera, D. Franco, A. Aranega Jimenez, G. Babaeva, N. Chizh, S. Galchenko, B. Sandomirsky, M. Schwarzl, S. Seiler, P. Steendijk, S. Huber, H. Maechler, M. Truschnig-Wilders, B. Pieske, H. Post, S. Simrick, R. Kreutzer, C. Rao, C. M. Terracciano, P. Kirchhof, L. Fabritz, T. Brand, M. Theveniau-Ruissy, P. Parisot, A. Francou, E. Saint-Michel, K. Mesbah, R. G. Kelly, H.-T. Wu, S.-S. Sie, C.-Y. Chen, T.-C. Kuan, C. S. Lin, Z. Ismailoglu, M. Guven, A. Yakici, Y. Ata, S. Ozcan, E. Yildirim, Z. Ongen, V. Miroshnikova, E. Demina, T. Rodygina, P. Kurjanov, A. Denisenko, A. Schwarzman, A. Rubanenko, Y. Shchukin, A. Germanov, M. Goldbergova, J. Parenica, J. Lipkova, N. Pavek, P. Kala, M. Poloczek, A. Vasku, I. Parenicova, J. Spinar, C. Gambacciani, E. Chiavacci, M. Evangelista, N. Vesentini, C. Kusmic, L. Pitto, A. Chernova, S. U. Y. Nikulina, D. A. Arvanitis, I. Mourouzis, C. Pantos, E. G. Kranias, D. V. Cokkinos, D. Sanoudou, T. E. Vladimirskaya, I. A. Shved, S. G. Kryvorot, I. M. Schirmer, A. Appukuttan, L. Pott, K. Jaquet, Y. Ladilov, C. R. Archer, M. D. Bootman, H. L. Roderick, A. Fusco, D. Sorriento, G. Santulli, B. Trimarco, G. Iaccarino, M. Hagenmueller, J. Riffel, E. Bernhold, H. A. Katus, S. E. Hardt, A. Maqsood, M. Zi, S. Prehar, L. Neyses, S. Ray, D. Oceandy, N. Khatami, P. Wadowski, V. Wagh, J. Hescheler, A. Sachinidis, W. Mohl, B. Chaudhry, D. Burns, D. J. Henderson, N. A. M. Bax, M. H. Van Marion, B. Shah, M. J. Goumans, C. V. C. Bouten, D. W. J. Van Der Schaft, A. A. M. Van Oorschot, S. Maas, J. Braun, J. Van Tuyn, A. A. F. De Vries, A. C. Gittenberger-De Groot, S. Bageghni, M. J. Drinkhill, T. F. C. Batten, J. F. X. Ainscough, B. Onate, G. Vilahur, R. Ferrer-Lorente, J. Ybarra, A. Diez-Caballero, C. Ballesta-Lopez, F. Moscatiello, J. Herrero, L. Badimon, E. Martin-Rendon, D. M. Clifford, S. A. Fisher, S. J. Brusnkill, C. Doree, A. Mathur, M. Clarke, S. M. Watt, R. Hernandez-Vera, D. Kavanagh, A. I. Yemm, J. Frampton, N. Kalia, Y. Terajima, T. Shimizu, S. Tsuruyama, H. Ishii, H. Sekine, N. Hagiwara, T. Okano, K. R. Vrijsen, S. A. J. Chamuleau, J. P. G. Sluijter, P. F. M. Doevendans, R. Madonna, S. Delli Pizzi, L. Di Donato, A. Mariotti, L. Di Carlo, E. D'ugo, M. A. Teberino, A. Merla, A. T, R. De Caterina, L. Kolker, N. N. Ali, K. Maclellan, M. Moore, J. Wheeler, S. E. Harding, R. A. Fleck, J. M. Rowlinson, N. Kraenkel, R. Ascione, P. Madeddu, J. F. O'sullivan, A. L. Leblond, G. Kelly, A. H. S. Kumar, P. Metharom, C. K. Buneker, N. Alizadeh-Vikali, B. G. Hynes, R. O'connor, N. M. Caplice, M. Noseda, A. J. De Smith, T. Leja, P. H. Rao, F. Al-Beidh, M. S. Abreu Pavia, A. I. Blakemore, M. D. Schneider, K. Stathopoulou, F. Cuello, E. Ehler, R. S. Haworth, M. Avkiran, H. Morawietz, C. Eickholt, H. Langbein, M. Brux, C. Goettsch, W. Goettsch, A. Arsov, C. Brunssen, L. Mazilu, I. R. Parepa, A. I. Suceveanu, A. P. Suceveanu, F. S. De Man, C. Guignabert, L. Tu, M. L. Handoko, I. Schalij, E. Fadel, P. E. Postmus, A. Vonk-Noordegraaf, M. Humbert, S. Eddahibi, C. Del Giudice, A. Anastasio, L. Fazal, F. Azibani, N. Bihry, R. Merval, E. Polidano, J.-L. Samuel, C. Delcayre, Y. Zhang, Y. M. Mi, L. L. Ren, Y. P. Cheng, R. Guo, Y. Liu, Y. N. Jiang, A. D. Kokkinos, P. Tretjakovs, A. Jurka, I. Bormane, I. Mikelsone, D. Reihmane, K. Elksne, G. Krievina, J. Verbovenko, G. Bahs, N. Lopez-Andres, A. Rousseau, L. Calvier, R. Akhtar, C. Labat, K. Cruickshank, J. Diez, F. Zannad, P. Lacolley, P. Rossignol, K. Hamesch, P. Subramanian, X. Li, A. Thiemann, K. Heyll, K. Dembowsky, E. Chevalier, C. Weber, A. Schober, L. Yang, G. Kim, B. Gardner, J. Earley, M. Hofmann-Bowman, C.-F. Cheng, W.-S. Lian, H. Lin, N. J. Jinjolia, G. A. Abuladze, S. H. T. Tvalchrelidze, I. Khamnagadaev, M. Shkolnikova, L. Kokov, I. Miklashevich, I. Drozdov, I. Ilyich, B. O. Bingen, S. F. A. Askar, D. L. Ypey, A. Van Der Laarse, M. J. Schalij, D. A. Pijnappels, C. H. Roney, F. S. Ng, R. A. Chowdhury, E. T. Y. Chang, P. M. Patel, A. R. Lyon, J. H. Siggers, N. S. Peters, A. Obergrussberger, S. Stoelzle, A. Bruggemann, C. Haarmann, M. George, N. Fertig, D. Moreira, A. Souza, P. Valente, J. Kornej, C. Reihardt, J. Kosiuk, A. Arya, G. Hindricks, V. Adams, D. Husser, A. Bollmann, P. Camelliti, J. Dudhia, P. Dias, J. Cartledge, D. J. Connolly, M. Nobles, S. Sebastian, A. Tinker, A. Opel, H. Daimi, A. Haj Khelil, J. Be Chibani, A. Barana, I. Amoros, M. Gonzalez De La Fuente, R. Caballero, A. Aranega, A. Kelly, O. Bernus, O. J. Kemi, R. C. Myles, I. A. Ghouri, F. L. Burton, G. L. Smith, M. Del Lungo, L. Sartiani, V. Spinelli, M. Baruscotti, D. Difrancesco, A. Mugelli, E. Cerbai, A. M. Thomas, Q. Aziz, T. Khambra, J. M. A. Addlestone, E. J. Cartwright, R. Wilkinson, W. Song, S. Marston, A. Jacquet, N. M. Mougenot, A. J. Lipskaia, E. R. Paalberends, K. Stam, S. J. Van Dijk, M. Van Slegtenhorst, C. Dos Remedios, F. J. Ten Cate, M. Michels, H. W. M. Niessen, G. J. M. Stienen, J. Van Der Velden, M. I. Read, A. A. Andreianova, J. C. Harrison, C. S. Goulton, D. S. Kerr, I. A. Sammut, M. Wallner, D. Von Lewinski, D. Kindsvater, M. Saes, I. Morano, A. Muegge, B. Buyandelger, S. Kostin, S. Gunkel, J. Vouffo, K. Ng, J. Chen, M. Eilers, R. Isaacson, H. Milting, R. Knoell, M.-E. Cattin, C. Crocini, S. Schlossarek, S. Maron, A. Hansen, T. Eschenhagen, L. Carrier, G. Bonne, R. Coppini, C. Ferrantini, I. Olivotto, L. Belardinelli, C. Poggesi, M. C. Leung, A. E. Messer, O. Copeland, S. B. Marston, A. M. Mills, T. Collins, P. O'gara, T. Thum, K. Regalla, K. T. Macleod, T. Prodromakis, U. Chaudhry, A. Darzi, M. H. Yacoub, T. Athanasiou, A. Bogdanova, A. Makhro, M. Hoydal, T. O. Stolen, A. B. Johnssen, M. Alves, D. Catalucci, G. Condorelli, L. G. Koch, S. L. Britton, U. Wisloff, V. Bito, P. Claus, K. Vermeulen, C. Huysmans, R. Ventura-Clapier, K. R. Sipido, M. N. Seliuk, A. P. Burlaka, E. P. Sidorik, N. V. Khaitovych, M. M. Kozachok, V. S. Potaskalova, R. B. Driesen, D. T. Galan, D. De Paulis, T. Arnoux, S. Schaller, R. M. Pruss, D. M. Poitz, A. Augstein, R. C. Braun-Dullaeus, A. Schmeisser, R. H. Strasser, P. Micova, P. Balkova, M. Hlavackova, J. Zurmanova, D. Kasparova, F. Kolar, J. Neckar, F. Novak, O. Novakova, S. Pollard, M. Babba, A. Hussain, R. James, H. Maddock, A. S. Alshehri, G. F. Baxter, B. Dietel, R. Altendorf, W. G. Daniel, R. Kollmar, C. D. Garlichs, R. Sirohi, N. Roberts, D. Lawrence, A. Sheikh, S. Kolvekar, J. Yap, M. Arend, G. Walkinshaw, D. J. Hausenloy, D. M. Yellon, A. Posa, R. Szabo, Z. Szalai, P. Szablics, M. A. Berko, K. Orban, Z. S. Murlasits, L. Balogh, C. Varga, H. C. Ku, M. J. Su, R.-M. Chreih, C. Ginghina, D. Deleanu, A. L. B. J. Ferreira, A. Belal, M. A. Ali, X. Fan, A. Holt, R. Campbell, R. Schulz, C. Bonanad, V. Bodi, J. Sanchis, J. M. Morales, V. Marrachelli, J. Nunez, M. J. Forteza, F. Chaustre, C. Gomez, F. J. Chorro, T. Csont, V. Fekete, Z. Murlasits, E. Aypar, P. Bencsik, M. Sarkozy, Z. V. Varga, P. Ferdinandy, G. D. Duerr, M. Zoerlein, D. Dewald, B. Mesenholl, P. Schneider, A. Ghanem, S. Rittling, A. Welz, O. Dewald, E. Becker, C. Peigney, C. Bouleti, A. Galaup, C. Monnot, B. Ghaleh, S. Germain, A. Timmermans, A. Ginion, C. De Meester, K. Sakamoto, J.-L. Vanoverschelde, S. Horman, C. Beauloye, L. Bertrand, N. Maroz-Vadalazhskaya, E. Drozd, L. Kukharenko, I. Russkich, D. Krachak, Y. Seljun, Y. Ostrovski, A.-C. Martin, B. Le Bonniec, T. Lecompte, B. Dizier, J. Emmerich, A.-M. Fischer, C.-M. Samama, A. Godier, S. Mogensen, E. M. Furchtbauer, C. Aalkjaer, W. L. Choong, A. Jovanovic, F. Khan, J. M. Daniel, J. M. Dutzmann, R. Widmer-Teske, D. Guenduez, D. Sedding, M. M. Castro, J. J. C. Cena, W. J. C. Cho, G. G. Goobie, M. P. W. Walsh, R. S. Schulz, J. Dutzmann, K. T. Preissner, W. Sones, M. Kotlikoff, K. Serizawa, K. Yogo, K. Aizawa, M. Hirata, Y. Tashiro, N. Ishizuka, A. Varela, M. Katsiboulas, D. Tousoulis, T. G. Papaioannou, S. Vaina, C. H. Davos, C. Piperi, C. Stefanadis, E. K. Basdra, A. G. Papavassiliou, C. Hermenegildo, M. Lazaro-Franco, A. Sobrino, C. Bueno-Beti, N. Martinez-Gil, T. Walther, C. Peiro, C. F. Sanchez-Ferrer, S. Novella, M. Ciccarelli, A. Franco, G. W. Dorn, P. Cseplo, O. Torok, Z. S. Springo, Z. Vamos, D. Kosa, J. Hamar, A. Koller, K. J. Bubb, A. Ahluwalia, E. L. Stepien, A. Gruca, J. Grzybowska, J. Goralska, A. Dembinska-Kiec, J. Stolinski, L. Partyka, H. Zhang, D. Sweeney, G. N. Thomas, P. V. Fish, D. P. Taggart, S. Cioffi, M. Bilio, S. Martucciello, E. Illingworth, A. Caporali, S. Shantikumar, M. Marchetti, F. Martelli, C. Emanueli, M. Meloni, A. Al Haj Zen, G. Sala-Newby, S. Del Turco, C. Saponaro, B. Dario, S. Sartini, A. Menciassi, P. Dario, C. La Motta, G. Basta, V. Santiemma, C. Bertone, F. Rossi, E. Michelon, M. J. Bianco, A. Castelli, D. I. Shin, K. B. Seung, S. M. Seo, H. J. Park, P. J. Kim, S. H. Baek, Y. S. Choi, S. H. Her, D. B. Kim, J. M. Lee, C. S. Park, S. Rocchiccioli, A. Cecchettini, G. Pelosi, L. Citti, O. Parodi, M. G. Trivella, D. Michel-Monigadon, F. Burger, S. Dunoyer-Geindre, G. Pelli, B. Cravatt, S. Steffens, A. Didangelos, U. Mayr, X. Yin, C. Stegemann, J. Shalhoub, A. H. Davies, C. Monaco, M. Mayr, S. Lypovetska, S. Grytsenko, I. U. Njerve, A. A. Pettersen, T. B. Opstad, V. Bratseth, H. Arnesen, I. Seljeflot, I. E. Dumitriu, P. Baruah, R. F. Antunes, J. C. Kaski, I. Trapero, I. Benet, C. Alguero, F. J. Chaustre, A. Mangold, S. Puthenkalam, K. Distelmaier, C. Adlbrecht, I. M. Lang, T. Koizumi, I. Inoue, N. Komiyama, S. Nishimura, O. N. Korneeva, O. M. Drapkina, L. Fornai, A. Angelini, A. Kiss, F. Giskes, G. Eijkel, M. Fedrigo, M. L. Valente, G. Thiene, R. M. A. Heeren, T. Padro, L. Casani, R. Suades, B. Bertoni, R. Carminati, V. Carlini, L. Pettinari, C. Martinelli, N. Gagliano, G. Noppe, P. Buchlin, N. Marquet, N. Baeyens, N. Morel, A. Baysa, J. Sagave, C. P. Dahl, L. Gullestad, A. Carpi, F. Di Lisa, M. Giorgio, J. Vaage, G. Valen, E. Vafiadaki, V. Papalouka, G. Terzis, K. Spengos, P. Manta, C. Gales, G. Genet, E. Dague, O. Cazorla, B. Payre, C. Mias, A. Ouille, A. Lacampagne, A. Pathak, J. M. Senard, M. Abonnenc, P. Da Costa Martins, S. Srivastava, M. Gautel, L. De Windt, L. Comelli, C. Lande, N. Ucciferri, L. Ikonen, H. Vuorenpaa, K. Kujala, J.-R. Sarkanen, T. Heinonen, T. Ylikomi, K. Aalto-Setala, H. Capros, N. Sprincean, N. Usurelu, V. Egorov, N. Stratu, V. Matchkov, E. Bouzinova, N. Moeller-Nielsen, O. Wiborg, P. S. Gutierrez, R. Aparecida-Silva, L. F. Borges, L. F. P. Moreira, R. R. Dias, J. Kalil, N. A. G. Stolf, W. Zhou, K. Suntharalingam, N. Brand, R. Vilar Compte, L. Ying, K. Bicknell, A. Dannoura, P. Dash, G. Brooks, I. Tsimafeyeu, Y. Tishova, N. Wynn, I. P. Oyeyipo, L. A. Olatunji, L. Maegdefessel, J. Azuma, R. Toh, U. Raaz, D. R. Merk, A. Deng, J. M. Spin, P. S. Tsao, L. Tedeschi, M. Taranta, I. Naldi, S. Grimaldi, C. Cinti, M. Bousquenaud, F. Maskali, S. Poussier, P. Y. Marie, H. Boutley, G. Karcher, D. R. Wagner, Y. Devaux, I. Torre, S. Psilodimitrakopoulos, I. Iruretagoiena, A. Gonzalez-Tendero, D. Artigas, P. Loza-Alvarez, E. Gratacos, I. Amat-Roldan, L. Murray, D. M. Carberry, P. Dunton, M. J. Miles, M.-S. Suleiman, K. Kanesalingam, R. Taylor, C. N. Mc Collum, A. Parniczky, M. Solymar, A. Porpaczy, A. Miseta, Z. S. Lenkey, S. Szabados, A. Cziraki, J. Garai, I. Myloslavska, S. M. Menazza, M. C. Canton, F. D. L. Di Lisa, S. H. V. Oliveira, C. A. S. Morais, M. R. Miranda, T. T. Oliveira, M. R. A. Lamego, L. M. Lima, N. S. Goncharova, A. V. Naymushin, A. V. Kazimli, O. M. Moiseeva, M. G. Carvalho, A. P. Sabino, A. P. L. Mota, M. O. Sousa, A. Niessner, B. Richter, P. J. Hohensinner, K. Rychli, G. Zorn, R. Berger, D. Moertl, R. Pacher, J. Wojta, M. Huelsmann, G. Kukharchik, N. Nesterova, A. Pavlova, L. Gaykovaya, N. Krapivka, I. Konstantinova, L. Sichinava, S. Prapa, K. P. Mccarthy, P. J. Kilner, X. Y. Xu, M. R. Johnson, S. Y. Ho, M. A. Gatzoulis, E. G. Stoupel, R. Garcia, D. Merino, C. Montalvo, M. A. Hurle, J. F. Nistal, A. V. Villar, A. Perez-Moreno, R. Gilabert, and E. Ros
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medicine.medical_specialty ,Endocrinology ,Physiology ,Activator (genetics) ,Chemistry ,Physiology (medical) ,Internal medicine ,medicine ,AMPK ,Myocyte ,Long-term potentiation ,Metabolism ,Cardiology and Cardiovascular Medicine - Published
- 2012
4. Compound and individual effect of heterozygous missense mutations in long QT syndrome
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A. Polyakova, L. Shagam, R. Ildarova, M. Shkolnikova, and V. Sukhorukov
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- 2015
- Full Text
- View/download PDF
5. Tilt-Test in Children With Sinus Bradycardia and Recurrent Syncope
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M. Shkolnikova and T. Shkolenko
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medicine.medical_specialty ,biology ,medicine.diagnostic_test ,business.industry ,Sinus bradycardia ,Syncope (genus) ,Cardiac arrhythmia ,medicine.disease ,biology.organism_classification ,law.invention ,Tilt table test ,law ,Physiology (medical) ,Internal medicine ,Anesthesia ,Heart rate ,Cardiology ,Medicine ,Tilt test ,Artificial cardiac pacemaker ,Asystole ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business - Abstract
The purpose of this study is to estimate whether a response on tilt test could help for clarifying the risk for development of life-threatening arrhythmia in children with sinus bradycardia (SB). 29 children aged 10 to 18 years old with SB (heart rate < 25‰ on resting ECG) and recurrent syncope were studied with 12-lead ECG, echocardiography, 24-hour Holter, transesophageal EPS, tilt-test (TT). Emotional distress (28%), sight of blood (21%), sudden pain (10%), prolonged standing (31%), and stuffy rooms (69%) were found as the precipitating events. 22 children (76%) demonstrated more than one provocative factor. Cardiogenic nature of syncope did not approve with routine examination. The sensitivity of TT was 48%. Positive responses on TT according to VASIS criteria were classified as mixed - 42%, pure vasodepression −28%, and cardioinhibition −28%: type 2A in 1 child, and type 2B in 3 children with asystole 9, 11, and 33 sec. The pacemaker implantation was recommended for all 3 children with asystole (11%). TT should be recommended for all children with SB and recurrent syncope.
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- 2005
6. Cold pressure testing 99 Tc MIBI-SPECT useful detecting abnormal coronary vasoreactivity in asymptomatic population with moderate risk of cardiovascular events. PARADIGMA multicenter study
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J.P. Hellermann, S. Svetlana Sazonova, Thierry C. Gillebert, Stephan G. Nekolla, R. Seabra-Gomes, Rob S. Beanlands, S. Mot, N. Avigni, S. Kumar, M. El-Gabaly, K. Sawinski, T. K. Ip, M. Mehdi Namdar, M. Popiel, Deborah Katten, Alexander Battler, R. T. Robert Tuttle, A. Ferro, Jung-Joon Min, C. Claudia Medrea, Poul Flemming Høilund-Carlsen, M. Cappagli, Shin Young Jeong, Jean N. DaSilva, D. Baranov, S. Grajek, M. Cafiero, Bruce Darrow, R. Berta, Leonie Gordon, H. Iida, L. A. Providência, Gérald Vanzetto, Tuvia Ben-Gal, W. Dafoe, L. E. Mastrocolla, M. I. Miyamoto, A. Imperiale, W. Yasunori, P. Malagutti, Mario Beretta, Y. Ohta, M. Komarnicki, M. Lupo, E. Nariaki, A. Oliveira, P. Beraldo, P. G. Danias, J. Jae-Tae Lee, S. Lima, M. Beheshti, Matthias Pfisterer, M. Valgimigli, Torsten Toftegaard Nielsen, A. L. Patroncini, Y. Kou, H. Haddad, S. Werden, M. Shkolnikova, J. C. R. Pereira, M. Møldrup, W. Watanabe Yasuhi, P De Bondt, D. Horstkotte, D. Baller, J. Jens Hedega Kristensen, G. Storto, Linda Garrard, Olivier De Winter, A. Alexandru Naum, Palaniswamy Shanmuga Sundaram, R. Czepczynski, Fawad Kazi, A. Lazar, Philipp A. Kaufmann, E. Inglese, Gregory S. Thomas, M. Mariana Vasconcelos, W. Acampa, J. H. Bae, A. Ventosa, H. W. Christensen, G. De Backer, S. Panareo, Mette Madsen, Alan W. Ahlberg, Nili Zafrir, L. Feggi, Rosa Levy, H. Hanne Sondergaard, M. Balducelli, A. Amir Ausef, V. Larionova, A. W. Ahlberg, C. A. Molina, O. Berkovich, T. Faria, Jennifer J. Thomas, Senta Graf, Claudio Marcassa, D. Cragnolino, T. Yasuhiko, C. R. E. Sampaio, E. Ernest Podrasky, E. Shlyakhto, A. Rener, Alfredo R. Galassi, Patrick T. Siegrist, D. L. Rice, A. Meretta, P. Chacon, G. Moscatelli, V. Oikonen, N. Bartenstein, Frank M. Bengel, Gerald Maurer, C. Tamburino, M. Ferreira, L. Vidal, O. Masoli, A. Epps, S. Akihiro, C. Grasso, A. Cieslinski, A. Zarrilli, P. Calza, M. De Buyzere, I. Esipovich, G. Porenta, M. Oettinger, P. Smanio, C. Pollack, W. Burchert, P. T. Siegrist, D. Bernard, R. Ferrari, A. Thom, F. Bertagna, Y. Akio, H. Eidherr, L. Grynberg, David M. O’Sullivan, T. Kunimasa, J. Sowinski, M. Petretta, J. Lima, L. Corrado, Gary V. Heller, D. B. Kramer, V. Timoshin, I. Leka, N. Henke, M. Salvatore, P. Breborowicz, Keiichiro Yoshinaga, A. Whalen, Ho-Chun Song, C. Gatti, B. Lamp, Werner Vach, C. Van de Wiele, M. J. Järvisalo, T. Zornitzki, T. Kimio, M. Maeng, J. Candell-Riera, R. Delaloye, M. Giganti, R. deKemp, Tatsuhiko Furuhashi, Pascal Koepfli, Taher El-Kady, Heikki Ukkonen, J. Kemppainen, S. Padma, E. V. Lima, R. Capilneanu, R. Couto, T. Ivashchenko, W. Wadsak, Gavin L Noble, Heinz Sochor, C. Corbelli, S. Traverso, C Lourenço, Stefano Severi, Pasquale Perrone Filardi, William E. Boden, P. Wielepp, Jan Mueller-Brand, P. Jacon, J. Alvarez-Sabin, K. Kruschke, Shung Chull Chae, M. S. Laaksonen, A. Poliakov, A. Kammeier, Y. J. Heo, J. Knuuti, U. Schurr, S. Vered, Torben Haghfelt, E. Fricke, M. Namdar, M. Polimeno, Masao Moroi, J. Holzinger, M. El-Sayed, Hiroshi Watabe, A. Cuocolo, L. Raposo, Byeong-Cheol Ahn, J. H. Seo, J. Wolfram, G. Vecchi, D. Faraggi, C. Poetzi, F. Rodrigues, C. Rappallo, A. Caspi, M. Lesiak, Alejandro Solodky, E. Elisabetta Varani, M.L. De Rimini, Ian G. Burwash, R. Bogdan, Kurt Kletter, A. Czyz, J. Hausleiter, K. Khaled Elsaban, May Aung, H. Fukuda, A. Johansen, S. Chiarameda, P.L Pieri, M. Rehling, N. Reichek, R. C. Thompson, P. Giannuzzi, Georgios I Papaioannou, A. Ferrer-Antunes, M. Redruello, G. Medolago, J. Montaner, P. Nuutila, Rudi Dierckx, G. Brevetti, C. A. R. Oliveira, E. Martins, T. Hayashi, V. Vickenty Kozulin, D. Fagret, R. Campini, G. Cyr, Kathryn Williams, S. Dellegrottaglie, Hans Erik Bøtker, K. B. Lee, A. Panov, Anja Velghe, G. V. Heller, G. De Leon, S. Sachin Navare, M. Garcia, Santiago Aguadé-Bruix, U. M. Mortensen, L. S. Linda Shaw, Morten Bøttcher, P. E. Smanio, Alberto Cuocolo, F. Buccoliero, D. Glogar, G. Percoco, C. Aguiar, V. Gil, A. Szeto, Regina S. Druz, R. Grathwohl, M. Gyongyosi, M. Souvatzoglou, R. Davies, Corrado Cittanti, Israel Mats, Benjamin J.W. Chow, S. Chuprova, J. S. Berg, N. Teramoto, H. Tuunanen, K.K. Haridas, M. Zachariah, F. Rocha-Gonçalves, A. Rovira, Hee-Seung Bom, C. Roque, J. De Sutter, Justin Lundbye, J. Calqueiro, A. Yehia, Michael W. Hanson, Néstor Perez Baliño, J. M. Rossi, M. Gordeev, N. Burova, S. Moshiri, Markus Schwaiger, P. Sullo, E. Zaklyazminskaya, N.R. Van de Veire, O. O. Akinboboye, M. Chiariello, S. Viňas, Salvador Borges-Neto, Paulo Schiavom Duarte, A. Gonzalez, A. Ausef, E. Bagatin, M. Langlois, E. Leotta, R. Casanova, Aliasghar Khorsand, Ole Schmitz, D. Rosa, J. Machecourt, Shay Livschitz, C. A. Wyss, Terence D. Ruddy, K. Ryou, H. Knobler, G. Romero-Farina, S. Azzarelli, I. Vidal, P. C. Burger, A. Maresta, P. F. Poul F. Høilund-Carlsen, J. Vogt, J. F. Arenillas, J. Pereira, Michael J. Zellweger, A. António Ferreira, G. Karanikas, Kenneth Nichols, and O. Lindner
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business.industry ,Medicine ,Radiology, Nuclear Medicine and imaging ,Medical emergency ,Cardiology and Cardiovascular Medicine ,business ,medicine.disease ,Outcome (game theory) - Published
- 2005
7. The use of phenotype characteristics in mutation analysis of families with long QT syndrome
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S. Chuprova, A. Poliakov, E. Zaklyazminskaya, and M. Shkolnikova
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Genetics ,business.industry ,Long QT syndrome ,Mutation testing ,Medicine ,Radiology, Nuclear Medicine and imaging ,Cardiology and Cardiovascular Medicine ,business ,medicine.disease ,Phenotype - Published
- 2005
8. Psychotropic drugs in the treatment of psychovegetative disorders in children
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M. Shkolnikova, V. Brutman, I. Kireeva, Yu. Belosiorov, and A.A. Severny
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Biological Psychiatry - Published
- 1997
9. The Structure of Phosphorylated Complexones and Their Complexes with Metals
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N. M. Dyjatlova, K. I. Popov, and L. M. Shkolnikova
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Inorganic Chemistry ,Metal ,Chemistry ,Crystal chemistry ,visual_art ,Organic Chemistry ,Polymer chemistry ,visual_art.visual_art_medium ,Organic chemistry ,Protonation ,Biochemistry - Abstract
The stereochemistry and crystal chemistry of amino-alkylphosphonic and alkylidenediphosphonic complexones and corresponding metal complexonates was studied. The details of the structure of the complexones and protonated anions were revealed. Common features of the structure in comparison to the aminoalkylcarboxylic complexonas are discribed.
- Published
- 1990
10. Paediatric and adult congenital cardiology education and training in Europe.
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McMahon CJ, Heying R, Budts W, Cavigelli-Brunner A, Shkolnikova M, Michel-Behnke I, Kozlik-Feldmann R, Wåhlander H, DeWolf D, Difilippo S, Kornyei L, Russo MG, Kaneva-Nencheva A, Mesihovic-Dinarevic S, Vesel S, Oskarsson G, Papadopoulos G, Petropoulos AC, Cevik BS, Jossif A, Doros G, Krusensjerna-Hafstrom T, Dangel J, Rahkonen O, Albert-Brotons DC, Alvares S, Brun H, Janousek J, Pitkänen-Argillander O, Voges I, Lubaua I, Sendzikaite S, Magee AG, Rhodes MJ, Blom NA, Bu'Lock F, Hanseus K, and Milanesi O
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- Humans, Adult, Child, Certification, Curriculum, Fellowships and Scholarships, Europe, Cardiology education
- Abstract
Background: Limited data exist on training of European paediatric and adult congenital cardiologists., Methods: A structured and approved questionnaire was circulated to national delegates of Association for European Paediatric and Congenital Cardiology in 33 European countries., Results: Delegates from 30 countries (91%) responded. Paediatric cardiology was not recognised as a distinct speciality by the respective ministry of Health in seven countries (23%). Twenty countries (67%) have formally accredited paediatric cardiology training programmes, seven (23%) have substantial informal (not accredited or certified) training, and three (10%) have very limited or no programme. Twenty-two countries have a curriculum. Twelve countries have a national training director. There was one paediatric cardiology centre per 2.66 million population (range 0.87-9.64 million), one cardiac surgical centre per 4.73 million population (range 1.63-10.72 million), and one training centre per 4.29 million population (range 1.63-10.72 million population). The median number of paediatric cardiology fellows per training programme was 4 (range 1-17), and duration of training was 3 years (range 2-5 years). An exit examination in paediatric cardiology was conducted in 16 countries (53%) and certification provided by 20 countries (67%). Paediatric cardiologist number is affected by gross domestic product (R
2 = 0.41)., Conclusion: Training varies markedly across European countries. Although formal fellowship programmes exist in many countries, several countries have informal training or no training. Only a minority of countries provide both exit examination and certification. Harmonisation of training and standardisation of exit examination and certification could reduce variation in training thereby promoting high-quality care by European congenital cardiologists.- Published
- 2022
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11. Left Cardiac Sympathetic Denervation for Long QT Syndrome: 50 Years' Experience Provides Guidance for Management.
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Dusi V, Pugliese L, De Ferrari GM, Odero A, Crotti L, Dagradi F, Castelletti S, Vicentini A, Rordorf R, Li C, Shkolnikova M, Spazzolini C, and Schwartz PJ
- Subjects
- Adrenergic beta-Antagonists therapeutic use, Female, Humans, Male, Retrospective Studies, Sympathectomy adverse effects, Sympathectomy methods, Syncope etiology, Treatment Outcome, Long QT Syndrome diagnosis, Long QT Syndrome surgery
- Abstract
Objectives: This study sought to report our single-center experience with left cardiac sympathetic denervation (LCSD) for long QT syndrome (LQTS) since 1973., Background: LCSD is still underutilized because clinicians are often uncertain whether to use it versus an implantable cardioverter-defibrillator (ICD)., Methods: We performed LCSD in 125 patients with LQTS (58% women, mean QT interval corrected for frequency [QTc] 527 ± 60 ms, 90% on beta blockers) with a follow-up of 12.9 ± 10.3 years. They were retrospectively divided into 4 groups according to the clinical/genetic status: very high risk (n = 18, symptomatic in the first year of life or with highly malignant genetics), with aborted cardiac arrest (ACA) (n = 31), with syncope and/or ICD shocks on beta blockers (n = 45), in primary prevention (n = 31)., Results: After LCSD, 17% in the very high risk group remained asymptomatic, compared with 52%, 47%, and 97% in the other 3 groups (P < 0.0001), with an overall 86% decrease in the mean yearly cardiac event rate (P < 0.0001). Among 45 patients with only syncope/ICD shocks before LCSD, none had ACA/sudden death as first symptom after LCSD and a 6-month post-LCSD QTc <500 ms predicted excellent outcome. Patients with a QTc ≥500 ms have a 50% chance of shortening it by an average of 60 ms. LCSD results are not affected by common genotypes., Conclusions: We provide definitive evidence for the long-term efficacy of LCSD in LQTS. The degree of antiarrhythmic protection is influenced by patient's specificity and amount of QTc shortening. This novel approach to the analysis of the outcome allows cardiologists to rationally decide and tailor their management strategies to the individual features of their patients., Competing Interests: Funding Support and Author Disclosures Drs Schwartz and Crotti were partially supported by Leducq Foundation for Cardiovascular Research, grant 18CVD05, “Towards Precision Medicine with Human iPSCs for Cardiac Channelopathies.” All other authors have reported that they have no relationships relevant to the contents of this paper to disclose., (Copyright © 2022 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.)
- Published
- 2022
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12. Video-assisted thoracoscopic pacemaker lead placement in children with atrioventricular block.
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Termosesov S, Kulbachinskaya E, Polyakova E, Khaspekov D, Grishin I, Bereznitskaya V, and Shkolnikova M
- Abstract
Background: The pacemaker lead placement is presented as one of the most appropriate procedures in children with a complete atrioventricular block (AVB). Despite the fact that video-assisted thoracic surgery (VATS) for epicardial lead placement has demonstrated positive results as to the feasibility, safety, and efficacy in adults, its role in pacemaker implantation in children remains unclear., Aim: This study sought to assess the intermediate-term outcomes of video-assisted thoracoscopic pacemaker lead placement in children with complete AVB., Materials and Methods: From May 2017 to November 2019, five children with complete AVB underwent minimally invasive left ventricular (LV) lead placements via thoracoscopic video assistance approach. The procedure was performed under complex intratracheal anesthesia with single-lung ventilation, all pacing parameters were evaluated in perioperative and follow-up periods., Results: The median age of children at implantation was 3 years (range: 2 to 4 years), the median weight was 13 kg (range: 12-15 kg). All procedures were completed successfully, pacing thresholds for the active lead measured 0.3-1.1V, with R-wave amplitude of 8-18 mV and impedance of 560-1478 Ohm., Conclusion: Thoracoscopic pacemaker lead placement may provide a potential alternative to the transthoracic approach of epicardial lead placement in children with AVB., Competing Interests: There are no conflicts of interest., (Copyright: © 2020 Annals of Pediatric Cardiology.)
- Published
- 2021
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13. Handgrip strength and its prognostic value for mortality in Moscow, Denmark, and England.
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Oksuzyan A, Demakakos P, Shkolnikova M, Thinggaard M, Vaupel JW, Christensen K, and Shkolnikov VM
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- Aged, Aged, 80 and over, Aging, Denmark, England, Female, Health Status, Humans, Longitudinal Studies, Male, Middle Aged, Moscow, Proportional Hazards Models, Prospective Studies, Risk Factors, Social Class, Hand Strength, Mortality, Prognosis
- Abstract
Background: This study compares handgrip strength and its association with mortality across studies conducted in Moscow, Denmark, and England., Materials: The data collected by the Study of Stress, Aging, and Health in Russia, the Study of Middle-Aged Danish Twins and the Longitudinal Study of Aging Danish Twins, and the English Longitudinal Study of Ageing was utilized., Results: Among the male participants, the age-standardized grip strength was 2 kg and 1 kg lower in Russia than in Denmark and in England, respectively. The age-standardized grip strength among the female participants was 1.9 kg and 1.6 kg lower in Russia than in Denmark and in England, respectively. In Moscow, a one-kilogram increase in grip strength was associated with a 4% (hazard ratio [HR] = 0.96, 95% confidence interval [CI]: 0.94, 0.99) reduction in mortality among men and a 10% (HR = 0.90, 95%CI: 0.86, 0.94) among women. Meanwhile, a one-kilogram increase in grip strength was associated with a 6% (HR = 0.94, 95%CI: 0.93, 0.95) and an 8% (HR = 0.92, 95%CI: 0.90, 0.94) decrease in mortality among Danish men and women, respectively, and with a 2% (HR = 0.98, 95%CI: 0.97, 0.99) and a 3% (HR = 0.97, 95%CI: 0.95, 0.98) reduction in mortality among the English men and women, respectively., Conclusion: The study suggests that, although absolute grip strength values appear to vary across the Muscovite, Danish, and English samples, the degree to which grip strength is predictive of mortality is comparable across national populations with diverse socioeconomic and health profiles and life expectancy levels.
- Published
- 2017
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14. Response to Letters Regarding Article, "Clinical Management of Catecholaminergic Polymorphic Ventricular Tachycardia: The Role of Left Cardiac Sympathetic Denervation".
- Author
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De Ferrari GM, Dusi V, Spazzolini C, Bos JM, Abrams DJ, Berul CI, Crotti L, Eldar M, Kharlap M, Khoury A, Krahn AD, Leenhardt A, Moir CR, Odero A, Nordkamp LO, Paul T, I Noguer FR, Shkolnikova M, Till J, Wilde AA, Ackerman MJ, and Schwartz PJ
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- Female, Humans, Male, Disease Management, Sympathectomy, Tachycardia, Ventricular diagnosis, Tachycardia, Ventricular surgery
- Published
- 2016
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15. Sex Differences in Biological Markers of Health in the Study of Stress, Aging and Health in Russia.
- Author
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Oksuzyan A, Shkolnikova M, Vaupel JW, Christensen K, and Shkolnikov VM
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- Aged, Female, Humans, Male, Russia, Aging physiology, Biomarkers metabolism, Health, Sex Characteristics, Stress, Physiological
- Abstract
Background: The apparent contradiction that women live longer but have worse health than men, the so called male-female health-survival paradox, is very pronounced in Russia. The present study investigates whether men in Moscow are healthier than women at the level of biomarkers, and whether the associations between biomarkers and subjective health have sex-specific patterns., Materials: Previously collected data in the study of Stress, Aging, and Health in Russia (SAHR, n = 1800) were used to examine sex differences in biomarkers and their associations with physical functioning and self-rated health., Results: The present study found mixed directions and magnitudes for sex differences in biomarkers. Women were significantly disadvantaged with regard to obesity and waist circumference, whereas men had a tendency toward higher prevalence of electrocardiographic abnormalities. No sex differences were indicated in the prevalence of immunological biomarkers, and mixed patterns were found for lipid profiles. Many biomarkers were associated with physical functioning and general health. Obesity and waist circumference were related to lower physical functioning among females only, while major Q-wave abnormalities with high probabilities of myocardial infarction and atrial fibrillation or atrial flutter were associated with physical functioning and self-rated health among males only., Conclusion: No clear patterns of sex differences in prevalence of high-risk levels of biomarkers suggest that the male-female health-survival paradox is weaker at the level of health biomarkers. We found some evidence that certain biomarkers reflecting pathophysiological changes in the organism that do not possess acute health risks, but over many years may lead to physical disability, are associated with physical functioning and self-rated health in women, whereas others reflecting more serious life-threatening pathophysiological changes are associated with physical functioning and self-rated health in men.
- Published
- 2015
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16. Clinical Management of Catecholaminergic Polymorphic Ventricular Tachycardia: The Role of Left Cardiac Sympathetic Denervation.
- Author
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De Ferrari GM, Dusi V, Spazzolini C, Bos JM, Abrams DJ, Berul CI, Crotti L, Davis AM, Eldar M, Kharlap M, Khoury A, Krahn AD, Leenhardt A, Moir CR, Odero A, Olde Nordkamp L, Paul T, Rosés I Noguer F, Shkolnikova M, Till J, Wilde AA, Ackerman MJ, and Schwartz PJ
- Subjects
- Adolescent, Child, Female, Follow-Up Studies, Humans, Male, Tachycardia, Ventricular physiopathology, Treatment Outcome, Disease Management, Sympathectomy methods, Tachycardia, Ventricular diagnosis, Tachycardia, Ventricular surgery
- Abstract
Background: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a genetic disorder causing life-threatening arrhythmias whenever sympathetic activity increases. β-Βlockers are the mainstay of therapy; when they fail, implantable cardioverter-defibrillators (ICDs) are used but often cause multiple shocks. Preliminary results with flecainide appear encouraging. We proposed left cardiac sympathetic denervation (LCSD) as useful additional therapy, but evidence remains anecdotal., Methods and Results: We report 63 patients with CPVT who underwent LCSD as secondary (n=54) or primary (n=9) prevention. The median post-LCSD follow-up was 37 months. The 9 asymptomatic patients remained free of major cardiac events. Of the 54 patients with prior major cardiac events either on (n=38) or off (n=16) optimal medical therapy, 13 (24%) had at least 1 recurrence: 0 patients had an aborted cardiac arrest, 2 patients had syncope only, 10 patients had ≥1 appropriate ICD discharges, and 1 patient died suddenly. The 1- and 2-year cumulative event-free survival rates were 87% and 81%. The percentage of patients with major cardiac events despite optimal medical therapy (n=38) was reduced from 100% to 32% (P<0.001) after LCSD, and among 29 patients with a presurgical ICD, the rate of shocks dropped by 93% from 3.6 to 0.6 shocks per person per year (P<0.001). Patients with an incomplete LCSD (n=7) were more likely to experience major cardiac events after LCSD (71% versus 17%; P<0.01) than those with a complete LCSD., Conclusions: LCSD is an effective antifibrillatory intervention for patients with CPVT. Whenever syncope occurs despite optimal medical therapy, LCSD could be considered the next step rather than an ICD and could complement ICDs in patients with recurrent shocks., (© 2015 American Heart Association, Inc.)
- Published
- 2015
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17. Latent time-varying factors in longitudinal analysis: a linear mixed hidden Markov model for heart rates.
- Author
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Lagona F, Jdanov D, and Shkolnikova M
- Subjects
- Age Distribution, Aged, Aged, 80 and over, Aging psychology, Biomarkers, Comorbidity, Female, Humans, Likelihood Functions, Linear Models, Longitudinal Studies, Male, Markov Chains, Middle Aged, Russia epidemiology, Sex Distribution, Stress, Psychological epidemiology, Time Factors, Aging physiology, Health Status, Heart Diseases epidemiology, Heart Rate, Stress, Psychological physiopathology
- Abstract
Longitudinal data are often segmented by unobserved time-varying factors, which introduce latent heterogeneity at the observation level, in addition to heterogeneity across subjects. We account for this latent structure by a linear mixed hidden Markov model. It integrates subject-specific random effects and Markovian sequences of time-varying effects in the linear predictor. We propose an expectationŰ-maximization algorithm for maximum likelihood estimation, based on data augmentation. It reduces to the iterative maximization of the expected value of a complete likelihood function, derived from an augmented dataset with case weights, alternated with weights updating. In a case study of the Survey on Stress Aging and Health in Russia, the model is exploited to estimate the influence of the observed covariates under unobserved time-varying factors, which affect the cardiovascular activity of each subject during the observation period., (Copyright © 2014 John Wiley & Sons, Ltd.)
- Published
- 2014
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18. Sex differences in health and mortality in Moscow and Denmark.
- Author
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Oksuzyan A, Shkolnikova M, Vaupel JW, Christensen K, and Shkolnikov VM
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- Aged, Cross-Cultural Comparison, Cross-Sectional Studies, Denmark epidemiology, Female, Humans, Male, Middle Aged, Moscow epidemiology, Population Surveillance, Self Report, Sex Distribution, Sex Factors, Socioeconomic Factors, Aging, Health Status, Health Status Indicators, Life Expectancy, Mortality
- Abstract
In high income countries females outlive men, although they generally report worse health, the so-called male-female health-survival paradox. Russia has one of the world's largest sex difference in life expectancy with a male disadvantage of more than 10 years. We compare components of the paradox between Denmark and Moscow by examining sex differences in mortality and several health measures. The Human Mortality Database and the Russian Fertility and Mortality Database were used to examine sex differences in all-cause death rates in Denmark, Russia, and Moscow in 2007-2008. Self-reported health data were obtained from the Study of Middle-Aged Danish Twins (n = 4,314), the Longitudinal Study of Aging Danish Twins (n = 4,731), and the study of Stress, Aging, and Health in Russia (n = 1,800). In both Moscow and Denmark there was a consistent female advantage at ages 55-89 years in survival and a male advantage in self-rated health, physical functioning, and depression symptomatology. Only on cognitive tests males performed similarly to or worse than women. Nevertheless, Muscovite males had more than twice higher mortality at ages 55-69 years compared to Muscovite women, almost double the ratio in Denmark. The present study showed that despite similar directions of sex differences in health and mortality in Moscow and Denmark, the male-female health-survival paradox is very pronounced in Moscow suggesting a stronger sex-specific disconnect between health indicators and mortality among middle-aged and young-old Muscovites.
- Published
- 2014
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19. Perceived stress and biological risk: is the link stronger in Russians than in Taiwanese and Americans?
- Author
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Glei DA, Goldman N, Shkolnikov VM, Jdanov D, Shkolnikova M, Vaupel JW, and Weinstein M
- Subjects
- Adult, Aged, Aged, 80 and over, Biomarkers, Cardiovascular System physiopathology, Creatinine metabolism, Cross-Sectional Studies, Female, Heart Rate, Humans, Hydrocortisone blood, Inflammation physiopathology, Male, Middle Aged, Moscow epidemiology, Neurosecretory Systems physiology, Risk Factors, Sex Factors, Taiwan epidemiology, United States epidemiology, Allostasis physiology, Asian People psychology, Perception physiology, Stress, Psychological physiopathology, White People psychology
- Abstract
Allostatic load theory implies a relationship between exposure to psychological stress and multi-system physiological dysregulation. We used data from population-based samples of men and women in Russia (Moscow; n = 1800; age, mean 68.6 years), Taiwan (n = 1036; 65.6 years) and the United States (US; n = 1054; 58.0 years) -- which are likely to vary widely with respect to levels of stress exposure and biological markers -- to determine the magnitude of the association between perceived stress and physiological dysregulation. The measure of overall dysregulation was based on 15 markers including standard cardiovascular/metabolic risk factors as well as markers of inflammation and neuroendocrine activity. Subjective psychological stress was measured by the perceived stress scale. Only the Moscow sample demonstrated a positive association with overall dysregulation in both sexes. In the US, we found an association among women but not men. Among the Taiwanese, who report the lowest perceived stress, there was no association in women but an unexpected inverse relationship in men. The effects also varied across system-level subscores: the association with perceived stress was most consistent for standard cardiovascular/metabolic factors. Perceived stress was associated with inflammation and neuroendocrine activity in some samples. Although the evidence that perceived stress is the primary source of physiological dysregulation is generally modest, it was stronger in Russia where the level of perceived stress was particularly high. For Russia only, we had information about heart function based on a 24 h ambulatory electrocardiogram; perceived stress was consistently associated with heart rate dysregulation in Russian men and women.
- Published
- 2013
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20. To what extent do biomarkers account for the large social disparities in health in Moscow?
- Author
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Glei DA, Goldman N, Shkolnikov VM, Jdanov D, Shalnova S, Shkolnikova M, and Weinstein M
- Subjects
- Aged, Aged, 80 and over, Cardiovascular Diseases, Female, Health Surveys, Heart Rate, Humans, Inflammation, Male, Middle Aged, Moscow, Neurosecretory Systems, Risk Factors, Biomarkers, Health Status Disparities, Social Class
- Abstract
The Russian population continues to face political and economic challenges, has experienced poor general health and high mortality for decades, and has exhibited widening health disparities. The physiological factors underlying links between health and socioeconomic position in the Russian population are therefore an important topic to investigate. We used data from a population-based survey of Moscow residents aged 55 and older (n = 1495), fielded between December 2006 and June 2009, to address two questions. First, are social disparities evident across different clusters of biomarkers? Second, does biological risk mediate the link between socioeconomic status and health? Health outcomes included subscales for general health, physical function, and bodily pain. Socioeconomic status was represented by education and an index of material resources. Biological risk was measured by 20 biomarkers including cardiovascular, inflammatory, and neuroendocrine markers as well as heart rate parameters from 24-h ECG monitoring. For both sexes, the age-adjusted educational disparity in standard cardiovascular risk factors was substantial (men: standardized β = -0.16, 95% CI = -0.23 to -0.09; women: β = -0.25, CI = -0.32 to -0.18). Education differences in inflammation were also evident in both men (β = -0.17, CI = -0.25 to -0.09) and women (β = -0.09, CI = -0.17 to -0.01). Heart rate parameters differed by education only in men (β = -0.10, CI = -0.18 to -0.02). The associations between material resources and biological risk scores were generally weaker than those for education. Social disparities in neuroendocrine markers were negligible for men and women. In terms of mediating effects, biological risk accounted for more of the education gap in general health and physical function (19-36%) than in bodily pain (12-18%). Inclusion of inflammatory markers and heart rate parameters-which were important predictors of health outcomes-may explain how we accounted for more of the social disparities than previous studies., (Copyright © 2012 Elsevier Ltd. All rights reserved.)
- Published
- 2013
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21. Biological mechanisms of disease and death in Moscow: rationale and design of the survey on Stress Aging and Health in Russia (SAHR).
- Author
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Shkolnikova M, Shalnova S, Shkolnikov VM, Metelskaya V, Deev A, Andreev E, Jdanov D, and Vaupel JW
- Subjects
- Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Moscow epidemiology, Research Design, Social Class, Aging, Health Status Indicators, Mortality, Stress, Psychological
- Abstract
Background: Prior research has revealed large differences in health and mortality across countries, socioeconomic groups, and individuals. Russia experiences one of the world's highest levels of all-cause and cardiovascular mortality, great mortality differences within the population, and a heavy burden of ill health. Psychological stress has been suggested as a likely explanation of health loss and premature death in Russia and Eastern Europe. However, physiological mechanisms connecting stress with health in Russia remain unclear since existing epidemiological data are scarce and limited to conventional risk factors., Method and Design: The survey on Stress Aging and Health in Russia (SAHR) is addressing this knowledge gap by collecting an unusually rich database that includes a wide range of reported information, physical and cognitive health outcomes, and biomarkers in a sample of Muscovite men and women aged 55 and older. The total planned sample size is 2,000 individuals. The sample was randomly selected from epidemiological cohorts formed in Moscow between the mid-1970s and the 1990s and from medical population registers. The baseline data collection was carried out from December 2006 to June 2009. Interviews and medical tests were administered at hospital or at home according to standardized protocol. Questionnaire information includes health, socio-demographic characteristics, economic well-being, cognitive functioning, and batteries on stress and depression. Biomarkers include anthropometry, grip strength, resting ECG, conventional cardiovascular factors of risk such as lipid profile and blood pressure, and other biochemical parameters such as those related to inflammation, glucose and insulin resistance, coagulation, fibrinolysis, and stress hormones. In addition to these measurements, SAHR includes dynamic biomarkers provided by 24-hour ECG (Holter) monitoring. This method continuously registers the beat-to-beat heart rate in naturalistic conditions without restrictions on normal daily activities. It provides information about heart functioning, including heart rate variability and ischemic and arrhythmic events.Re-examination of the study subjects will be conducted in 2009-2011 and will focus on health, functional status, economic conditions, behaviors, and attitudes towards aging. The subjects are also followed up for mortality and non-fatal health events., Discussion: The SAHR will produce a valuable set of established and novel biomarkers combined with self-reported data for the international research community and will provide important insights into factors and biological mechanisms of mortality and health losses in Russia.
- Published
- 2009
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22. The Jervell and Lange-Nielsen syndrome: natural history, molecular basis, and clinical outcome.
- Author
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Schwartz PJ, Spazzolini C, Crotti L, Bathen J, Amlie JP, Timothy K, Shkolnikova M, Berul CI, Bitner-Glindzicz M, Toivonen L, Horie M, Schulze-Bahr E, and Denjoy I
- Subjects
- Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Child, Child, Preschool, Data Collection, Family Health, Female, Genotype, Humans, Infant, KCNQ1 Potassium Channel genetics, Male, Middle Aged, Potassium Channels, Voltage-Gated genetics, Sex Factors, Survival Analysis, Treatment Outcome, Jervell-Lange Nielsen Syndrome etiology, Jervell-Lange Nielsen Syndrome genetics, Jervell-Lange Nielsen Syndrome mortality, Jervell-Lange Nielsen Syndrome therapy
- Abstract
Background: Data on the Jervell and Lange-Nielsen syndrome (J-LN), the long-QT syndrome (LQTS) variant associated with deafness and caused by homozygous or compound heterozygous mutations on the KCNQ1 or on the KCNE1 genes encoding the I(Ks) current, are still based largely on case reports., Methods and Results: We analyzed data from 186 J-LN patients obtained from the literature (31%) and from individual physicians (69%). Most patients (86%) had cardiac events, and 50% were already symptomatic by age 3. Their QTc was markedly prolonged (557+/-65 ms). Most of the arrhythmic events (95%) were triggered by emotions or exercise. Females are at lower risk for cardiac arrest and sudden death (CA/SD) (hazard ratio, 0.54; 95% CI, 0.34 to 0.88; P=0.01). A QTc >550 ms and history of syncope during the first year of life are independent predictors of subsequent CA/SD. Most mutations (90.5%) are on the KCNQ1 gene; mutations on the KCNE1 gene are associated with a more benign course. beta-Blockers have only partial efficacy; 51% of the patients had events despite therapy and 27% had CA/SD., Conclusions: J-LN syndrome is a most severe variant of LQTS, with a very early onset and major QTc prolongation, and in which beta-blockers have limited efficacy. Subgroups at relatively lower risk for CA/SD are identifiable and include females, patients with a QTc < or =550 ms, those without events in the first year of life, and those with mutations on KCNE1. Early therapy with implanted cardioverter/defibrillators must be considered.
- Published
- 2006
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23. Genomic organization of the KCNQ1 K+ channel gene and identification of C-terminal mutations in the long-QT syndrome.
- Author
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Neyroud N, Richard P, Vignier N, Donger C, Denjoy I, Demay L, Shkolnikova M, Pesce R, Chevalier P, Hainque B, Coumel P, Schwartz K, and Guicheney P
- Subjects
- Base Sequence, Female, Humans, KCNQ Potassium Channels, KCNQ1 Potassium Channel, Male, Microsatellite Repeats, Long QT Syndrome genetics, Mutation, Potassium Channels genetics, Potassium Channels, Voltage-Gated
- Abstract
The voltage-gated K+ channel KVLQT1 is essential for the repolarization phase of the cardiac action potential and for K+ homeostasis in the inner ear. Mutations in the human KCNQ1 gene encoding the alpha subunit of the KVLQT1 channel cause the long-QT syndrome (LQTS). The autosomal dominant form of this cardiac disease, the Romano-Ward syndrome, is characterized by a prolongation of the QT interval, ventricular arrhythmias, and sudden death. The autosomal recessive form, the Jervell and Lange-Nielsen syndrome, also includes bilateral deafness. In the present study, we report the entire genomic structure of KCNQ1, which consists of 19 exons spanning 400 kb on chromosome 11p15.5. We describe the sequences of exon-intron boundaries and oligonucleotide primers that allow polymerase chain reaction (PCR) amplification of exons from genomic DNA. Two new (CA)n repeat microsatellites were found in introns 10 and 14. The present study provides helpful tools for the linkage analysis and mutation screening of the complete KCNQ1 gene. By use of these tools, five novel mutations were identified in LQTS patients by PCR-single-strand conformational polymorphism (SSCP) analysis in the C-terminal part of KCNQ1: two missense mutations, a 20-bp and 1-bp deletions, and a 1-bp insertion. Such mutations in the C-terminal domain of the gene may be more frequent than previously expected, because this region has not been analyzed so far. This could explain the low percentage of mutations found in large LQTS cohorts.
- Published
- 1999
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