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The synoptic, dynamic, energetic and thermodynamic conditions during the development of a baroclinic depression which affected the area of Cyprus from 5 to 9 February 2006 are studied. The depression was associated with extreme weather phenomena such as thunderstorms, strong winds, dust and high precipitation accumulations (amounting to 50% of the mean monthly value). The results underline the importance of the dynamic control on the cyclone's development and the important contribution of the system itself in the energetics of the atmosphere. The thermodynamic analysis has proved a very useful tool in identifying the convective potential of the atmosphere at various stages of the development.

A comparison is made between the precipitation forecasts by the non-hydrostatic limited area model LME of the German Weather Service (DWD) and observations from a network of rain gauges in Cyprus. This is a first attempt to carry out a preliminary verification and evaluation of the LME precipitation forecasts over the area of Cyprus. For the verification, model forecasts and observations were used covering an eleven month period, from 1/2/2005 till 31/12/2005. The observations were made by three Automatic Weather Observing Systems (AWOS) located at Larnaka and Paphos airports and at Athalassa synoptic station, as well as at 6, 6 and 8 rain gauges within a radius of about 30 km around these stations, respectively. The observations were compared with the model outputs, separately for each of the three forecast days. The "probability of detection" (POD) of a precipitation event and the "false alarm rate" (FAR) were calculated. From the selected cases of the forecast precipitation events, the average forecast precipitation amounts in the area around the three stations were compared with the measured ones. An attempt was also made to evaluate the model's skill in predicting the spatial distribution of precipitation and, in this respect, the geographical position of the maximum forecast precipitation amount was contrasted to the position of the corresponding observed maximum. Maps with monthly precipitation totals observed by a local network of 150 rain gauges were compared with the corresponding forecast precipitation maps.

The Troodos mountains in Cyprus are a hotspot of plant diversity and cultural heritage. However, the traditional uses of medicinal and aromatic plants (MAPs), a significant aspect of local culture, have not been thoroughly studied. The aim of this research was to document and analyze the traditional uses of MAPs in Troodos. Data on MAPs and their traditional uses were collected through interviews. A database was constructed with categorized information on the uses of 160 taxa belonging to 63 families. The quantitative analysis included the calculation and comparison of six indices of ethnobotanical importance. The cultural value index was selected to reveal the most culturally significant MAPs taxa, while the informant consensus index was utilized to quantify the consensus in information obtained related to uses of MAPs. Furthermore, the 30 most popular MAPs taxa, exceptional and fading uses, and the plant parts used for different purposes are described and reported. The results reveal a deep connection between the people of Troodos and the plants of the area. Overall, the study provides the first ethnobotanical assessment for the Troodos mountains in Cyprus, contributing to a better understanding of the diverse uses of MAPs in mountain regions of the Mediterranean.

The development of technology, like the widely-used off-the-shelf portable photosynthesis systems, for the quantification of leaf gas exchange rates and chlorophyll fluorescence offered photosynthesis research a massive boost. Gas exchange parameters in such photosynthesis systems are calculated as gas exchange rates per unit leaf area. In small chambers (

It is now widely known that research brain MRI, CT, and PET images may potentially be re-identified using face recognition, and this potential can be reduced by applying face-deidentification ("de-facing") software. However, for research MRI sequences beyond T1-weighted (T1-w) and T2-FLAIR structural images, the potential for re-identification and quantitative effects of de-facing are both unknown, and the effects of de-facing T2-FLAIR are also unknown. In this work we examine these questions (where applicable) for T1-w, T2-w, T2*-w, T2-FLAIR, diffusion MRI (dMRI), functional MRI (fMRI), and arterial spin labelling (ASL) sequences. Among current-generation, vendor-product research-grade sequences, we found that 3D T1-w, T2-w, and T2-FLAIR were highly re-identifiable (96-98%). 2D T2-FLAIR and 3D multi-echo GRE (ME-GRE) were also moderately re-identifiable (44-45%), and our derived T2* from ME-GRE (comparable to a typical 2D T2*) matched at only 10%. Finally, diffusion, functional and ASL images were each minimally re-identifiable (0-8%). Applying de-facing with mri_reface version 0.3 reduced successful re-identification to ≤8%, while differential effects on popular quantitative pipelines for cortical volumes and thickness, white matter hyperintensities (WMH), and quantitative susceptibility mapping (QSM) measurements were all either comparable with or smaller than scan-rescan estimates. Consequently, high-quality de-facing software can greatly reduce the risk of re-identification for identifiable MRI sequences with only negligible effects on automated intracranial measurements. The current-generation echo-planar and spiral sequences (dMRI, fMRI, and ASL) each had minimal match rates, suggesting that they have a low risk of re-identification and can be shared without de-facing, but this conclusion should be re-evaluated if they are acquired without fat suppression, with a full-face scan coverage, or if newer developments reduce the current levels of artifacts and distortion around the face., Competing Interests: Declaration of Competing Interest • Dr. Schwarz receives research funding from the National Institutes of Health, related and unrelated to this study. • Dr. Kremers received grant funding from NIH for this study, and from NIH, DOD, AstraZeneca, Biogen and Roche unrelated to this study. • Dr. Arani receives research funding from the NIH, unrelated to this study. • Dr. Savvides reports no disclosures. • Dr. Reid reports no disclosures. • Dr. Gunter receives funding from the NIH. • Mr. Senjem owns or has owned stock in medical related companies, unrelated to the current work, within the past 36 months: Align Technology, Inc., Inovio Pharmaceuticals, Inc., Mesa Laboratories, Inc., Nvidia, Inc., Johnson and Johnson, LHC Group, Inc., Natus Medical Inc., Varex Imaging Corporation. • Dr. Cogswell reports no disclosures. • Dr. Vemuri receives funding from the NIH. • Dr. Kantarci consults for Biogen Inc., receives research support from Avid Radiopharmaceuticals and Eli Lilly, and receives funding from NIH and Alzheimer's Drug Discovery Foundation. • Dr. Knopman served on a Data Safety Monitoring Board for the DIAN study. He served on a Data Safety monitoring Board for a tau therapeutic for Biogen but received no personal compensation. He is an investigator in clinical trials sponsored by Biogen, Lilly Pharmaceuticals and the University of Southern California. He serves as a consultant for Samus Therapeutics, Roche, Magellan Health and Alzeca Biosciences but receives no personal compensation. He receives research support from the NIH. • Dr. Petersen is a consultant for Roche, Inc., Merck, Inc., Biogen, Inc., Nestle, Inc., and Eisai, Inc., served on a DSMB for Genentech, Inc.; receives royalties from publishing Mild Cognitive Impairment (Oxford University Press, 2003) and UpToDate; and receives research support from the NIH (P30 AG062677 (PI) and U01-AG006786 (PI), R01-AG011378 (Co-I), U24 AG057437 (Co-PI), UF1 NS125417 (C0-PI) and U01–024904 (Co-I)). • Dr. Jack serves on an independent data monitoring board for Roche, has served as a speaker for Eisai, and consulted for Biogen, but he receives no personal compensation from any commercial entity. He receives research support from NIH and the Alexander Family Alzheimer's Disease Research Professorship of the Mayo Clinic., (Copyright © 2023. Published by Elsevier Inc.)

It is well known that de-identified research brain images from MRI and CT can potentially be re-identified using face recognition; however, this has not been examined for PET images. We generated face reconstruction images of 182 volunteers using amyloid, tau, and FDG PET scans, and we measured how accurately commercial face recognition software (Microsoft Azure's Face API) automatically matched them with the individual participants' face photographs. We then compared this accuracy with the same experiments using participants' CT and MRI. Face reconstructions from PET images from PET/CT scanners were correctly matched at rates of 42% (FDG), 35% (tau), and 32% (amyloid), while CT were matched at 78% and MRI at 97-98%. We propose that these recognition rates are high enough that research studies should consider using face de-identification ("de-facing") software on PET images, in addition to CT and structural MRI, before data sharing. We also updated our mri&#95;reface de-identification software with extended functionality to replace face imagery in PET and CT images. Rates of face recognition on de-faced images were reduced to 0-4% for PET, 5% for CT, and 8% for MRI. We measured the effects of de-facing on regional amyloid PET measurements from two different measurement pipelines (PETSurfer/FreeSurfer 6.0, and one in-house method based on SPM12 and ANTs), and these effects were small: ICC values between de-faced and original images were > 0.98, biases were <2%, and median relative errors were < 2%. Effects on global amyloid PET SUVR measurements were even smaller: ICC values were 1.00, biases were <0.5%, and median relative errors were also <0.5%., (Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.)

Science students increasingly need programming and data science skills to be competitive in the modern workforce. However, at our university (San Francisco State University), until recently, almost no biology, biochemistry, and chemistry students (from here bio/chem students) completed a minor in computer science. To change this, a new minor in computing applications, which is informally known as the Promoting Inclusivity in Computing (PINC) minor, was established in 2016. Here, we present the lessons we learned from our experience in a set of 10 rules. The first 3 rules focus on setting up the program so that it interests students in biology, chemistry, and biochemistry. Rules 4 through 8 focus on how the classes of the program are taught to make them interesting for our students and to provide the students with the support they need. The last 2 rules are about what happens "behind the scenes" of running a program with many people from several departments involved., Competing Interests: The authors have declared that no competing interests exist.

Introduction: Despite the significant progress that has been made during the last decade, Greece still faces the effects of road traffic accidents (RTAs) to a great extent every year. This study represents an epidemiological approach to road traffic injuries (RTIs) presenting to a secondary hospital in a geographical area with very low-quality road network; it aims to indicate possible preventive measures and actions., Methods: The present study was conducted in Rethymnon General Hospital between January 2018 and February 2020. Data from all trauma patients who presented to the emergency department (ED) after RTAs were retrospectively collected from patient medical records. The severity of injury sustained by road traffic victims was graded using the Injury Severity Score (ISS)., Results: During the study period, 1582 trauma patients presented to the ED after RTAs. There were 1079 men and 503 women and the median age was 30 years. In total, 818 motorcycle-related injuries (51.7%), 497 automobile-related injuries (31.4%), 165 bicycle-related injuries (10.4%) and 102 pedestrian injuries (6.4%) were documented. Of the 1582 trauma patients, 58.2% (921) presented with injuries to the extremities, 35.3% (554) presented with thoracic injuries, 34.4% (541) presented with head injuries, 30% (475) presented with spinal column injuries, 17.4% (271) presented with facial injuries, 12.9% (203) presented with abdominal injuries and 10.3% (162) presented with pelvic injuries. A significant increase in the number of incidents was noticed during the tourist season. Median ISS was 2 (IQR=4). 53.7% of patients who were transferred to the hospital by ambulance had an ISS&le;4. In 41 cases, transportation to a tertiary hospital was necessary, six patients had emergency operations and 13 others died in the ED. The median length of hospital stay was 3 (IQR=6) days., Conclusion: Actions that could possibly mitigate the burden of RTIs in the district of Rethymnon include upgrading the level of law enforcement, implementing educational strategies and information campaigns against inappropriate ambulance use, encouraging facilities to develop trauma registries and ensuring adequate hospital staffing.

Variational Level Set (LS) has been a widely used method in medical segmentation. However, it is limited when dealing with multi-instance objects in the real world. In addition, its segmentation results are quite sensitive to initial settings and highly depend on the number of iterations. To address these issues and boost the classic variational LS methods to a new level of the learnable deep learning approaches, we propose a novel definition of contour evolution named Recurrent Level Set (RLS) 1 to employ Gated Recurrent Unit under the energy minimization of a variational LS functional. The curve deformation process in RLS is formed as a hidden state evolution procedure and updated by minimizing an energy functional composed of fitting forces and contour length. By sharing the convolutional features in a fully end-to-end trainable framework, we extend RLS to Contextual RLS (CRLS) to address semantic segmentation in the wild. The experimental results have shown that our proposed RLS improves both computational time and segmentation accuracy against the classic variational LS-based method whereas the fully end-to-end system CRLS achieves competitive performance compared to the state-of-the-art semantic segmentation approaches.

Although widely used, Multilinear PCA (MPCA), one of the leading multilinear analysis methods, still suffers from four major drawbacks. First, it is very sensitive to outliers and noise. Second, it is unable to cope with missing values. Third, it is computationally expensive since MPCA deals with large multi-dimensional datasets. Finally, it is unable to maintain the local geometrical structures due to the averaging process. This paper proposes a novel approach named Compressed Submanifold Multifactor Analysis (CSMA) to solve the four problems mentioned above. Our approach can deal with the problem of missing values and outliers via SVD-L1. The Random Projection method is used to obtain the fast low-rank approximation of a given multifactor dataset. In addition, it is able to preserve the geometry of the original data. Our CSMA method can be used efficiently for multiple purposes, e.g. noise and outlier removal, estimation of missing values, biometric applications. We show that CSMA method can achieve good results and is very efficient in the inpainting problem as compared to [1], [2]. Our method also achieves higher face recognition rates compared to LRTC, SPMA, MPCA and some other methods, i.e. PCA, LDA and LPP, on three challenging face databases, i.e. CMU-MPIE, CMU-PIE and Extended YALE-B.

We propose a facial alignment algorithm that is able to jointly deal with the presence of facial pose variation, partial occlusion of the face, and varying illumination and expressions. Our approach proceeds from sparse to dense landmarking steps using a set of specific models trained to best account for the shape and texture variation manifested by facial landmarks and facial shapes across pose and various expressions. We also propose the use of a novel l1-regularized least squares approach that we incorporate into our shape model, which is an improvement over the shape model used by several prior Active Shape Model (ASM) based facial landmark localization algorithms. Our approach is compared against several state-of-the-art methods on many challenging test datasets and exhibits a higher fitting accuracy on all of them.

In this paper, we investigate a single-sample periocular-based alignment-robust face recognition technique that is pose-tolerant under unconstrained face matching scenarios. Our Spartans framework starts by utilizing one single sample per subject class, and generate new face images under a wide range of 3D rotations using the 3D generic elastic model which is both accurate and computationally economic. Then, we focus on the periocular region where the most stable and discriminant features on human faces are retained, and marginalize out the regions beyond the periocular region since they are more susceptible to expression variations and occlusions. A novel facial descriptor, high-dimensional Walsh local binary patterns, is uniformly sampled on facial images with robustness toward alignment. During the learning stage, subject-dependent advanced correlation filters are learned for pose-tolerant non-linear subspace modeling in kernel feature space followed by a coupled max-pooling mechanism which further improve the performance. Given any unconstrained unseen face image, the Spartans can produce a highly discriminative matching score, thus achieving high verification rate. We have evaluated our method on the challenging Labeled Faces in the Wild database and solidly outperformed the state-of-the-art algorithms under four evaluation protocols with a high accuracy of 89.69%, a top score among image-restricted and unsupervised protocols. The advancement of Spartans is also proven in the Face Recognition Grand Challenge and Multi-PIE databases. In addition, our learning method based on advanced correlation filters is much more effective, in terms of learning subject-dependent pose-tolerant subspaces, compared with many well-established subspace methods in both linear and non-linear cases.

Automatic face recognition performance has been steadily improving over years of research, however it remains significantly affected by a number of factors such as illumination, pose, expression, resolution and other factors that can impact matching scores. The focus of this paper is the pose problem which remains largely overlooked in most real-world applications. Specifically, we focus on one-to-one matching scenarios where a query face image of a random pose is matched against a set of gallery images. We propose a method that relies on two fundamental components: (a) A 3D modeling step to geometrically correct the viewpoint of the face. For this purpose, we extend a recent technique for efficient synthesis of 3D face models called 3D Generic Elastic Model. (b) A sparse feature extraction step using subspace modeling and ℓ1-minimization to induce pose-tolerance in coefficient space. This in return enables the synthesis of an equivalent frontal-looking face, which can be used towards recognition. We show significant performance improvements in verification rates compared to commercial matchers, and also demonstrate the resilience of the proposed method with respect to degrading input quality. We find that the proposed technique is able to match non-frontal images to other non-frontal images of varying angles.

Over the past two decades, there have been a lot of advances in the field of pattern analyses for biomedical signals, which have helped in both medical diagnoses and in furthering our understanding of the human body. A relatively recent area of interest is the utility of biomedical signals in the field of biometrics, i.e., for user identification. Seminal work in this domain has already been done using electrocardiograph (ECG) signals. In this paper, we discuss our ongoing work in using a relatively recent modality of biomedical signals-a cardio-synchronous waveform measured using a Radio-Frequency Impedance-Interrogation (RFII) device for the purpose of user identification. Compared to an ECG setup, this device is noninvasive and measurements can be obtained easily and quickly. Here, we discuss the feasibility of reducing the dimensions of these signals by projecting onto various subspaces while still preserving interuser discriminating information. We compare the classification performance using classical dimensionality reduction methods such as principal component analysis (PCA), independent component analysis (ICA), random projections, with more recent techniques such as K-SVD-based dictionary learning. We also report the reconstruction accuracies in these subspaces. Our results show that the dimensionality of the measured signals can be reduced by 60 fold while maintaining high user identification rates.

In this paper, we employ several subspace representations (principal component analysis, unsupervised discriminant projection, kernel class-dependence feature analysis, and kernel discriminant analysis) on our proposd discrete transform encoded local binary patterns (DT-LBP) to match periocular region on a large data set such as NIST's face recognition grand challenge (FRGC) ver2 database. We strictly follow FRGC Experiment 4 protocol, which involves 1-to-1 matching of 8014 uncontrolled probe periocular images to 16 028 controlled target periocular images (~128 million pairwise face match comparisons). The performance of the periocular region is compared with that of full face with different illumination preprocessing schemes. The verification results on periocular region show that subspace representation on DT-LBP outperforms LBP significantly and gains a giant leap from traditional subspace representation on raw pixel intensity. Additionally, our proposed approach using only the periocular region is almost as good as full face with only 2.5% reduction in verification rate at 0.1% false accept rate, yet we gain tolerance to expression, occlusion, and capability of matching partial faces in crowds. In addition, we have compared the best standalone DT-LBP descriptor with eight other state-of-the-art descriptors for facial recognition and achieved the best performance. The two general frameworks are our major contribution: 1) a general framework that employs various generative and discriminative subspace modeling techniques for DT-LBP representation and 2) a general framework that encodes discrete transforms with local binary patterns for the creation of robust descriptors.

Periostin is a secreted extracellular matrix protein preferentially expressed in bone by osteocytes and periosteal osteoblasts. Reduced periostin expression may affect osteoblast differentiation and collagen type I synthesis and predispose to osteoporosis and increased fracture risk. We aimed to evaluate circulating periostin levels in postmenopausal women with low bone mass, their possible correlations with clinical and laboratory parameters, as well as the 3-month effect of zoledronic acid. Serum samples for periostin, 25-hydroxyvitamin D, parathyroid hormone (PTH), C-terminal telopeptide of type I collagen (CTx), and total alkaline phosphatase (tALP) were obtained from 46 postmenopausal women with low bone mass at baseline and 3 months after zoledronic acid infusion and from 30 age-matched, postmenopausal controls with normal bone mass at baseline. There was no difference in periostin levels between women with normal and low bone mass (250±15 vs. 272±14 ng/ml, respectively; p=0.279). Periostin remained essentially unchanged after zoledronic acid infusion (262±18 ng/ml; p=0.130). Serum periostin levels at baseline were not affected by previous bisphosphonate treatment, and were correlated only to tALP (rs=0.351; p=0.018). In multiple linear regression analysis, tALP (B=3.17; 95% CI=0.59-5.79; p=0.018) was associated with serum periostin levels at baseline, independently from previous anti-osteoporotic treatment, age, body mass index, and 25-hydroxyvitamin D. In conclusion, serum periostin levels do not differ between postmenopausal women with normal and low bone mass and are not affected by zoledronic acid treatment. Women with higher tALP have independently higher periostin levels., (© Georg Thieme Verlag KG Stuttgart · New York.)

Robust facial hair detection and segmentation is a highly valued soft biometric attribute for carrying out forensic facial analysis. In this paper, we propose a novel and fully automatic system, called SparCLeS, for beard/moustache detection and segmentation in challenging facial images. SparCLeS uses the multiscale self-quotient (MSQ) algorithm to preprocess facial images and deal with illumination variation. Histogram of oriented gradients (HOG) features are extracted from the preprocessed images and a dynamic sparse classifier is built using these features to classify a facial region as either containing skin or facial hair. A level set based approach, which makes use of the advantages of both global and local information, is then used to segment the regions of a face containing facial hair. Experimental results demonstrate the effectiveness of our proposed system in detecting and segmenting facial hair regions in images drawn from three databases, i.e., the NIST Multiple Biometric Grand Challenge (MBGC) still face database, the NIST Color Facial Recognition Technology FERET database, and the Labeled Faces in the Wild (LFW) database.

Unlabelled: Activin-A is expressed in bone and seems to regulate osteoclastogenesis. In this study, serum activin-A was increased in postmenopausal women with low bone mass and was positively correlated to age and negatively to lumbar spinal bone mineral density (BMD). Serum activin-A levels did not change 3 months after zoledronic acid infusion., Introduction: The aims of the study were to evaluate prospectively the circulating activin-A levels in postmenopausal women with low bone mass and explore possible correlations with clinical and laboratory data, as well as the 3-month effect of zoledronic acid infusion., Methods: Postmenopausal women with low bone mass assigned to receive zoledronic acid infusion (Patients, n = 47) and age-matched, postmenopausal women with normal bone mass (Controls, n = 27) were recruited on an outpatient basis. Main outcome measurement was serum activin-A levels., Results: Serum activin-A was higher in patients at baseline compared to controls (p < 0.001) and activin-A in the serum of patients and controls was positively correlated with age (Spearman's coefficient of correlation [rs] = 0.325; p = 0.005) and negatively with lumbar spinal (LS) BMD (rs = -0.425; p < 0.001). In multiple linear regression analysis, only age (B = 8.93; 95 % CI = 4.39-13.46; p < 0.001) was associated with serum activin-A levels at baseline, independent from group (patients or controls), previous anti-osteoporotic treatment, LS BMD and follicle-stimulating hormone. Circulating activin-A levels were not affected 3 months after zoledronic acid infusion., Conclusions: Serum activin-A is increased in postmenopausal women with low bone mass compared with postmenopausal women with normal bone mass and is positively correlated to age and negatively to LS BMD.

Iris masks play an important role in iris recognition. They indicate which part of the iris texture map is useful and which part is occluded or contaminated by noisy image artifacts such as eyelashes, eyelids, eyeglasses frames, and specular reflections. The accuracy of the iris mask is extremely important. The performance of the iris recognition system will decrease dramatically when the iris mask is inaccurate, even when the best recognition algorithm is used. Traditionally, people used the rule-based algorithms to estimate iris masks from iris images. However, the accuracy of the iris masks generated this way is questionable. In this work, we propose to use Figueiredo and Jain's Gaussian Mixture Models (FJ-GMMs) to model the underlying probabilistic distributions of both valid and invalid regions on iris images. We also explored possible features and found that Gabor Filter Bank (GFB) provides the most discriminative information for our goal. Finally, we applied Simulated Annealing (SA) technique to optimize the parameters of GFB in order to achieve the best recognition rate. Experimental results show that the masks generated by the proposed algorithm increase the iris recognition rate on both ICE2 and UBIRIS dataset, verifying the effectiveness and importance of our proposed method for iris occlusion estimation.

In this paper, we propose a novel method for generating a realistic 3D human face from a single 2D face image for the purpose of synthesizing new 2D face images at arbitrary poses using gender and ethnicity specific models. We employ the Generic Elastic Model (GEM) approach, which elastically deforms a generic 3D depth-map based on the sparse observations of an input face image in order to estimate the depth of the face image. Particularly, we show that Gender and Ethnicity specific GEMs (GE-GEMs) can approximate the 3D shape of the input face image more accurately, achieving a better generalization of 3D face modeling and reconstruction compared to the original GEM approach. We qualitatively validate our method using publicly available databases by showing each reconstructed 3D shape generated from a single image and new synthesized poses of the same person at arbitrary angles. For quantitative comparisons, we compare our synthesized results against 3D scanned data and also perform face recognition using synthesized images generated from a single enrollment frontal image. We obtain promising results for handling pose and expression changes based on the proposed method.

In this paper we explore how a Radio Frequency Impedance Interrogation (RFII) signal may be used as a biometric feature. This could allow the identification of subjects in operational and potentially hostile environments. Features extracted from the continuous and discrete wavelet decompositions of the signal are investigated for biometric identification. In the former case, the most discriminative features in the wavelet space were extracted using a Fisher ratio metric. Comparisons in the wavelet space were done using the Euclidean distance measure. In the latter case, the signal was decomposed at various levels using different wavelet bases, in order to extract both low frequency and high frequency components. Comparisons at each decomposition level were performed using the same distance measure as before. The data set used consists of four subjects, each with a 15 minute RFII recording. The various data samples for our experiments, corresponding to a single heart beat duration, were extracted from these recordings. We achieve identification rates of up to 99% using the CWT approach and rates of up to 100% using the DWT approach. While the small size of the dataset limits the interpretation of these results, further work with larger datasets is expected to develop better algorithms for subject identification.

Unlabelled: The use of Radio Frequency Impedance Interrogation (RFII) is being investigated for use as a noninvasive hemodynamic monitoring system and in the capacity of a biometric identifier. Biometric identification of subjects by cardiosynchronous waveform generated through RFII technology could allow the identification of subjects in operational and potentially hostile environments. Here, the filtering methods for extracting a unique biometric signature from the RFII signal are examined, including the use of Cepstral analysis for dynamically estimating the filter parameters., Methods: The projection of that signature to a Legendre Polynomial sub-space is proposed for increased class separability in a low dimensional space. Support Vector Machine (SVM) and k-Nearest Neighbor (k=3) classification are performed in the Legendre Polynomial sub-space on a small dataset., Results: Both the k-Nearest Neighbor and linear SVM methods demonstrated highly successful classification accuracy, with 93-100% accuracy demonstrated by various classification methods., Conclusions: The results are highly encouraging despite the small sample size. Further analysis with a larger dataset will help to refine this process for the eventual application of RFII as a robust biometric identifier.

Classical face recognition techniques have been successful at operating under well-controlled conditions; however, they have difficulty in robustly performing recognition in uncontrolled real-world scenarios where variations in pose, illumination, and expression are encountered. In this paper, we propose a new method for real-world unconstrained pose-invariant face recognition. We first construct a 3D model for each subject in our database using only a single 2D image by applying the 3D Generic Elastic Model (3D GEM) approach. These 3D models comprise an intermediate gallery database from which novel 2D pose views are synthesized for matching. Before matching, an initial estimate of the pose of the test query is obtained using a linear regression approach based on automatic facial landmark annotation. Each 3D model is subsequently rendered at different poses within a limited search space about the estimated pose, and the resulting images are matched against the test query. Finally, we compute the distances between the synthesized images and test query by using a simple normalized correlation matcher to show the effectiveness of our pose synthesis method to real-world data. We present convincing results on challenging data sets and video sequences demonstrating high recognition accuracy under controlled as well as unseen, uncontrolled real-world scenarios using a fast implementation.

Non-contact, non-invasive monitoring of hemodynamic parameters would be ideal for medical monitoring in a variety of environments. Radio Frequency Impedance Interrogation (RFII) measures hemodynamic function via resonance frequency coupling to a hydrophilic protein molecule. While the application of this technology to hemodynamic monitoring has demonstrated initial success, this preliminary study examined the use of RFII for subject identification by waveform signal analysis, which would allow confirmation of the identity of a subject in an operational setting prior to rescue efforts. Preliminary results demonstrate an excellent recognition rate using the RFII signature and pattern classification. Each individual has a consistent pattern during the initial waveform identification period that is visually distinct from the other individuals in the data set. These results suggest that RFII may be of great utility in the pre-hospital triage setting for patient monitoring and for the rapid identification of subjects in the operational setting.

Intermittent exogenous parathyroid hormone (PTH) is a potent osteoanabolic agent used for the treatment of severe osteoporosis. Two molecules of recombinant PTH are commercially available: the full-length PTH (PTH 1-84) and teriparatide (PTH 1-34). We present the first report of PTH-induced mild, asymptomatic, normochromic normocytic anemia in a postmenopausal woman treated sequentially with PTH 1-84 and PTH 1-34. Anemia was more pronounced with PTH 1-84 compared to PTH 1-34 and was reversed with each regimen discontinuation. We suggest monitoring of hematocrit and hemoglobin in PTH-treated patients, especially when PTH 1-84 is used.

Facial images change appearance due to multiple factors such as different poses, lighting variations, and facial expressions. Tensors are higher order extensions of vectors and matrices, which make it possible to analyze different appearance factors of facial variation. Using higher order tensors, we can construct a multilinear structure and model the multiple factors of face variation. In particular, among the appearance factors, the factor of a person's identity modeled by a tensor structure can be used for face recognition. However, this tensor-based face recognition creates difficulty in factorizing the unknown parameters of a new test image and solving for the person-identity parameter. In this paper, to break this limitation of applying the tensor-based methods to face recognition, we propose a novel tensor approach based on an individual-modeling method and nonlinear mappings. The proposed method does not require the problematic tensor factorization and is more efficient than the traditional TensorFaces method with respect to computation and memory. We set up the problem of solving for the unknown factors as a least squares problem with a quadratic equality constraint and solve it using numerical optimization techniques. We show that an individual-multilinear approach reduces the order of the tensor so that it makes face-recognition tasks computationally efficient as well as analytically simpler. We also show that nonlinear kernel mappings can be applied to this optimization problem and provide more accuracy to face-recognition systems than linear mappings. In this paper, we show that the proposed method, Individual Kernel TensorFaces, produces the better discrimination power for classification. The novelty in our approach as compared to previous work is that the Individual Kernel TensorFaces method does not require estimating any factor of a new test image for face recognition. In addition, we do not need to have any a priori knowledge of or assumption about the factors of a test image when using the proposed method. We can apply Individual Kernel TensorFaces even if the factors of a test image are absent from the training set. Based on various experiments on the Carnegie Mellon University Pose, Illumination, and Expression database, we demonstrate that the proposed method produces reliable results for face recognition.

As biometric authentication systems become more prevalent, it is becoming increasingly important to evaluate their performance. This paper introduces a novel statistical method of performance evaluation for these systems. Given a database of authentication results from an existing system, the method uses a hierarchical random effects model, along with Bayesian inference techniques yielding posterior predictive distributions, to predict performance in terms of error rates using various explanatory variables. By incorporating explanatory variables as well as random effects, the method allows for prediction of error rates when the authentication system is applied to potentially larger and/or different groups of subjects than those originally documented in the database. We also extend the model to allow for prediction of the probability of a false alarm on a "watch-list" as a function of the list size. We consider application of our methodology to three different face authentication systems: a filter-based system, a Gaussian Mixture Model (GMM)-based system, and a system based on frequency domain representation of facial asymmetry.

We describe a general probabilistic framework for matching patterns that experience in-plane nonlinear deformations, such as iris patterns. Given a pair of images, we derive a maximum a posteriori probability (MAP) estimate of the parameters of the relative deformation between them. Our estimation process accomplishes two things simultaneously: It normalizes for pattern warping and it returns a distortion-tolerant similarity metric which can be used for matching two nonlinearly deformed image patterns. The prior probability of the deformation parameters is specific to the pattern-type and, therefore, should result in more accurate matching than an arbitrary general distribution. We show that the proposed method is very well suited for handling iris biometrics, applying it to two databases of iris images which contain real instances of warped patterns. We demonstrate a significant improvement in matching accuracy using the proposed deformed Bayesian matching methodology. We also show that the additional computation required to estimate the deformation is relatively inexpensive, making it suitable for real-time applications.

Face recognition on mobile devices, such as personal digital assistants and cell phones, is a big challenge owing to the limited computational resources available to run verifications on the devices themselves. One approach is to transmit the captured face images by use of the cell-phone connection and to run the verification on a remote station. However, owing to limitations in communication bandwidth, it may be necessary to transmit a compressed version of the image. We propose using the image compression standard JPEG2000, which is a wavelet-based compression engine used to compress the face images to low bit rates suitable for transmission over low-bandwidth communication channels. At the receiver end, the face images are reconstructed with a JPEG2000 decoder and are fed into the verification engine. We explore how advanced correlation filters, such as the minimum average correlation energy filter [Appl. Opt. 26, 3633 (1987)] and its variants, perform by using face images captured under different illumination conditions and encoded with different bit rates under the JPEG2000 wavelet-encoding standard. We evaluate the performance of these filters by using illumination variations from the Carnegie Mellon University's Pose, Illumination, and Expression (PIE) face database. We also demonstrate the tolerance of these filters to noisy versions of images with illumination variations.

Using biometrics for subject verification can significantly improve security over that of approaches based on passwords and personal identification numbers, both of which people tend to lose or forget. In biometric verification the system tries to match an input biometric (such as a fingerprint, face image, or iris image) to a stored biometric template. Thus correlation filter techniques are attractive candidates for the matching precision needed in biometric verification. In particular, advanced correlation filters, such as synthetic discriminant function filters, can offer very good matching performance in the presence of variability in these biometric images (e.g., facial expressions, illumination changes, etc.). We investigate the performance of advanced correlation filters for face, fingerprint, and iris biometric verification.

A new correlation filter formulation (that we refer to as the minimax distance transform correlation filter (MDTCF) is presented that minimizes the average squared distance from the filtered desired (or true-) class training images to a filtered reference image while maximizing the mean squared distance of the filtered undesired (or false-) class training images to this filtered reference image. This approach increases the separation between the false-class correlation outputs and the true-class correlation outputs. Classification can be performned using the squared distance of a filtered test image to the chosen filtered reference image. We show that the previously introduced distance classifier correlation filter (DCCF) is similar to a special case of MDTCF. We also examine the differences between the DCCF and the MDTCF, and show that MDTCF can offer increased discrimination performance. Also, MDTCF performance is evaluated on two different face databases.

Four electrocardiographic scoring systems for the assessment of left ventricular function or presence of myocardial infarction were evaluated in 231 patients with coronary artery disease. Electrocardiographic scores were compared with radionuclide ejection fraction and thallium perfusion studies. The correlation between Wagner's modified QRS score and ejection fraction was only fair (r = -0.60). Askenazi's sum of R wave voltage score correlated poorly with ejection fraction (r = 0.44), as did Gottwik's sum of voltage score from the Frank lead electrocardiogram (r = 0.44). Rautaharju's Cardiac Infarction Injury Score did not reliably predict presence of infarction in the patient group, nor did it correlate well with ejection fraction (r = -0.49). None of the correlations were significantly improved when only patients with a history of a myocardial infarction, a thallium defect compatible with a scar or a diagnostic Q wave were considered. Although Wagner's QRS score correlated best with ejection fraction, all scoring systems had limited clinical usefulness for estimating ejection fraction.

In order to determine whether areas of ischemia identified by thallium-201 scintigraphy could be localized by exercise ECG, we studied 54 patients with stable coronary heart disease. All 54 patients had exercise-induced thallium-201 scintigraphic defects. Their exercise ECG test results were compared to their thallium-201 images and also to 14 low-risk normal subjects. Exercise data were analyzed for spatial ST vector shifts, using a computer program in order to most accurately classify ST segment depression and elevation. Thallium-201 ischemic defects detected in our patients included areas in the septum and the inferior, lateral, and anterior walls. Twenty-six of these 54 patients also had coronary angiography for classification and comparison as having either localized or generalized disease. None of the scintigraphic ischemic sites or angiographic diseased areas could be specifically identified by exercise-induced ST vector shifts. Therefore, the surface exercise ECG has limitations in localizing ischemia to specific areas of the myocardium.

In order to evaluate computerized methods of electrocardiographic signal processing, determination of QRS end, and measurement of criteria for ischemia, we analyzed the data from 42 male patients with coronary heart disease who underwent maximal treadmill testing. Electrocardiographic data were digitized on-line and leads X, V5, Y and Eigen V were later analyzed for noise content, isoelectric baseline, and ST parameters using the UCSD spatial electrocardiographic computer program. Various ST segment criteria for ischemia were calculated and compared. Noise was greater in lead Y and in all leads when the median was used for signal averaging. Two isoelectric baseline algorithms and three ST segment slope algorithms gave similar results. Spatially derived QRS end was highly correlated with the amplitude measured using a fixed time interval after peak R wave. Both ST area and ST midpoint estimates differed widely using two different algorithms for each. Regression equations were derived that make it possible to estimate QRS end or ST60 amplitudes in V5 from values in X or vice versa.

Sixteen patients with stable angina pectoris were studied in a double blind crossover manner utilizing treadmill exercise testing with the direct measurement of total body oxygen uptake, 1 and 24 hours after application of a 20 cm2 transdermal nitroglycerin system and identical placebo. Testing was performed after a 3 day lead-in period of treatment with either an active patch or placebo. Points of analysis were peak angina and the submaximal work load occurring at 4 minutes of exercise. No statistically significant differences were observed between nitroglycerin and placebo treatment in any of the rest hemodynamic or peak angina variables at 1 or 24 hours. A significant increase in the rate-pressure product at the submaximal work load was observed 1 hour after transdermal nitroglycerin relative to placebo application. However, no significant differences were observed in any of the other measured variables at the submaximal work load, 1 or 24 hours after nitroglycerin application. The once daily application of a 20 cm2 transdermal nitroglycerin system was ineffective in altering the exercise capacity of patients with angina pectoris. The lack of efficacy at 1 hour appears to be due to inadequate nitroglycerin blood levels; at 24 hours it may be due to tolerance.

Fourteen male patients with exercise test-induced angina and ST-segment depression underwent treadmill testing on three consecutive days to evaluate the reproducibility of certain treadmill variables. Computerized ST-segment analysis and expired gas analysis, including anaerobic threshold, were evaluated for reproducibility using an intra-class correlation coefficient analysis. Measured oxygen uptake at peak exercise displayed better reproducibility than total treadmill time, the onset of angina, and the gas exchange anaerobic threshold (ATGE). The double product, heart rate, and ST-segment displacement in lead X were found to be reproducible at peak exercise, the onset of angina, and the ATGE. The incorporation of gas exchange analysis can provide accurate physiologic determinants of exercise capacity in patients with angina pectoris. In addition, noninvasive estimates of myocardial oxygen demand and ischemia can be reproducibly determined. These findings have important implications for the design of studies evaluating the effects of an intervention on angina pectoris.