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5. OXGR1 is a candidate disease gene for human calcium oxalate nephrolithiasis

Author

Amar J. Majmundar, Eugen Widmeier, John F. Heneghan, Ankana Daga, Chen-Han Wilfred Wu, Florian Buerger, Hannah Hugo, Ihsan Ullah, Ali Amar, Isabel Ottlewski, Daniela A. Braun, Tilman Jobst-Schwan, Jennifer A. Lawson, Muhammad Yasir Zahoor, Nancy M. Rodig, Velibor Tasic, Caleb P. Nelson, Shagufta Khaliq, Ria Schönauer, Jan Halbritter, John A. Sayer, Hanan M. Fathy, Michelle A. Baum, Shirlee Shril, Shrikant Mane, Seth L. Alper, and Friedhelm Hildebrandt

Subjects
Genetics (clinical)
Abstract

Nephrolithiasis (NL) affects 1 in 11 individuals worldwide, leading to significant patient morbidity. NL is associated with nephrocalcinosis (NC), a risk factor for chronic kidney disease. Causative genetic variants are detected in 11-28% of NL and/or NC, suggesting additional NL/NC-associated genetic loci await discovery. Therefore, we employed genomic approaches to discover novel genetic forms of NL/NC.Exome sequencing and directed sequencing of the OXGR1 locus were performed in a worldwide NL/NC cohort. Putatively deleterious rare OXGR1 variants were functionally characterized.Exome sequencing revealed a heterozygous OXGR1 missense variant (c.371TG, p.L124R) co-segregating with calcium oxalate NL and/or NC disease in an autosomal dominant inheritance pattern within a multi-generational family with five affected individuals. OXGR1 encodes 2-oxoglutarate (α-ketoglutarate) receptor 1 in the distal nephron. In response to its ligand α-ketoglutarate (AKG), OXGR1 stimulates the chloride-bicarbonate exchanger Pendrin, which also regulates transepithelial calcium transport in cortical connecting tubules. Strong amino acid conservation in orthologues and paralogues, severe in silico prediction scores, and extreme rarity in exome population databases suggested the variant was deleterious. Interrogation of the OXGR1 locus in 1107 additional NL/NC families identified five additional deleterious dominant variants in five families with calcium oxalate NL/NC. Rare, potentially deleterious OXGR1 variants were enriched in NL/NC subjects relative to ExAC controls (ΧRare, dominant loss-of-function OXGR1 variants are associated with recurrent calcium oxalate NL/NC disease.

Published
2022

6. Presentation and outcomes of post‐transplant lymphoproliferative disorder at a single institution pediatric transplant center

Author

Gabriel Ramos‐Gonzalez, Robert Crum, Alec Allain, Timna Agur, Laura O’Melia, Steven Staffa, Sandra K. Burchett, Bradford Siegele, Olga Weinberg, Nancy M. Rodig, Rima Fawaz, Tajinder P Singh, Dawn A. Freiberger, and Heung Bae Kim

Subjects
Epstein-Barr Virus Infections, Transplantation, Pediatrics, Perinatology and Child Health, Humans, Organ Transplantation, Antigens, CD20, Child, Rituximab, Lymphoproliferative Disorders, Retrospective Studies
Abstract

This study aimed to characterize features present at the time of diagnosis and describe outcomes in patients with post-transplant lymphoproliferative disorder (PTLD) following pediatric solid organ transplantation.We performed a retrospective review of solid organ transplant patients who developed pathologically confirmed PTLD at our center from 2006 to 2016.Of 594 patients included in this study, 41(6.9%) were diagnosed with PTLD. Median age at transplant was 5.6(IQR 1.7-16.1) years. Proportion of PTLD cases by organ transplanted and median time (IQR) to disease onset were: heart 11/144(7.6%) at 13.6(8.5-55.6) months, lung 7/52(13.5%) at 9.1(4.9-35) months, kidney 8/255(3.1%) at 39.5(13.9-57.1) months, liver 12/125(9.6%) at 7.7(5.5-22) months, intestine 0/4(0%), and multi-visceral 3/14(21.4%) at 5.4(5.4-5.6) months. No significant correlation was seen between recipient EBV status at transplant and timing of development of PTLD. There were six early lesions, 15 polymorphic, 19 monomorphic, and one uncharacterizable PTLD. Following immunosuppression reduction, 30 patients received rituximab, and 14 required chemotherapy. At median 25(IQR 12-53) months follow-up from the onset of PTLD, eight patients died secondary to transplant related complications, three are alive with active disease, and 30 have no evidence of disease.PTLD is a significant complication following pediatric solid organ transplantation. EBV levels in conjunction with symptomatic presentation following transplant may assist in detection of PTLD. Most patients can achieve long-term disease-free survival through immunosuppression reduction, anti-CD20 treatment, and chemotherapy in refractory cases.

Published
2022
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7. Associations of body mass index (BMI) and BMI change with progression of chronic kidney disease in children

Author

Amy J, Kogon, Jennifer, Roem, Michael F, Schneider, Mark M, Mitsnefes, Babette S, Zemel, Bradley A, Warady, Susan L, Furth, and Nancy M, Rodig

Abstract

Obesity is prevalent among children with chronic kidney disease (CKD) and is associated with cardiovascular disease and reduced quality of life. Its relationship with pediatric CKD progression has not been described.We evaluated relationships between both body mass index (BMI) category (normal, overweight, obese) and BMI z-score (BMIz) change on CKD progression among participants of the Chronic Kidney Disease in Children study. Kaplan-Meier survival curves and multivariable parametric failure time models depict the association of baseline BMI category on time to kidney replacement therapy (KRT). Additionally, the annualized percentage change in estimated glomerular filtration rate (eGFR) was modeled against concurrent change in BMIz using multivariable linear regression with generalized estimating equations which allowed for quantification of the effect of BMIz change on annualized eGFR change.Participants had median age of 10.9 years [IQR: 6.5, 14.6], median eGFR of 50 ml/1.73 mObesity may represent a target of intervention to improve kidney function in children with non-glomerular CKD. A higher resolution version of the Graphical abstract is available as Supplementary information.

Published
2021

9. Rapid reversal of uremic neuropathy following renal transplantation in an adolescent

Author

Doreen T, Ho, Nancy M, Rodig, Heung B, Kim, Hart G W, Lidov, Frederic D, Shapiro, G Praveen, Raju, and Peter B, Kang

Subjects
Adolescent, Glomerulosclerosis, Focal Segmental, Biopsy, Neural Conduction, Kidney Transplantation, Axons, Article, Polyneuropathies, Treatment Outcome, nervous system, Sural Nerve, Humans, Female, Renal Insufficiency, Uremia
Abstract

Clinical and pathologic studies on adults with uremic neuropathy are numerous, but less is known about this disorder in children and adolescents. We report the clinical, electrophysiologic, and pathologic findings in an adolescent female with uremic neuropathy. Electrophysiologic findings were consistent with a primarily axonal sensorimotor polyneuropathy. Sural nerve biopsy revealed areas of focal depletion in myelin sheaths and loss of axons. Axonal degeneration with secondary myelin changes appears to be the characteristic pathology in this case, one of the youngest to our knowledge for which nerve biopsy data are available. Our patient experienced dramatic recovery after renal transplantation, similar to the reports of older patients.

Published
2011

10. Nutrition for the Critically Ill Pediatric Patient with Renal Dysfunction

Author

N. M. Rodig

Subjects
Nitrogen balance, medicine.medical_specialty, business.industry, Critically ill, medicine.medical_treatment, Continuous ambulatory peritoneal dialysis, Acute kidney injury, Inadequate oral intake, medicine.disease, Protein catabolism, Parenteral nutrition, medicine, Intensive care medicine, business, Dialysis
Abstract

During critical illness, total energy expenditure will be increased proportionate to the severity of the underlying illness. The aim of nutritional support is to blunt the negative nitrogen balance that may accompany a hypermetabolic or catabolic state. Careful assessment of energy requirements in critically ill children with acute kidney injury (AKI) is essential to optimize the nutritional plan. Inadequate nutritional support will result in poor protein retention and excessive support may predispose to metabolic derangements and fluid excess. In addition to the increased protein catabolism associated with critical illness, patients supported with dialysis will have additional nitrogen losses. These losses should be accounted for when protein intake is prescribed. Water-soluble vitamins will be removed with dialysis and should be supplemented accordingly to avoid deficits. If nutritional support is indicated due to inadequate oral intake, enteral nutrition is the preferred method of support. If volume restriction is necessary, feeds can be fortified to increase energy density. To optimize digestibility, similar proportions of fat, protein, and carbohydrate as the base formula should be provided.

Published
2008
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11. Contributors

Author

Enver Akalin, Alice Sue Appel, Gerald B. Appel, Shakil Aslam, Robert C. Atkins, Howard A. Austin, James E. Balow, Jonathan Barratt, Brendan J. Barrett, Bryan N. Becker, Tomas Berl, Catherine Blake, Peter G. Blake, Emily A. Blumberg, Joseph V. Bonventre, D. Craig Brater, William E. Braun, Emmanuel L. Bravo, Zachary Z. Brener, David M. Briscoe, Jonathan Bromberg, John Burkart, Giovambattista Capasso, Francesco P. Cappuccio, Culley C. Carson, Steven J. Chadban, Arlene B. Chapman, Joline L.T. Chen, Russell W. Chesney, Alfred K. Cheung, Monique E. Cho, Lewis M. Cohen, Paul R. Conlin, Dinna Cruz, Brett Cullis, Gary C. Curhan, John J. Curtis, Christopher J. Cutie, Giuseppe D-Amico, Simon J. Davies, Connie L. Davis, Sara N. Davison, Raffaele De Caterina, Laura M. Dember, Mark Denton, Thomas A. Depner, J. Eric Derksen, Vikas R. Dharnidharka, Bradley S. Dixon, Hamish Dobbie, Wilfred Druml, Thomas D. DuBose, Lance D. Dworkin, David H. Ellison, Stephen Z. Fadem, John Feehally, Donald A. Feinfeld, Steven Fishbane, John M. Fitzpatrick, Daniel J. Ford, Alessandro Fornasieri, Marc B. Garnick, Robert S. Gaston, Michael J. Germain, Pere Ginès, Joyce M. Gonin, Eddie L. Greene, Scott M. Grundy, Mounira Habli, Andrew Hall, Mitchell L. Halperin, Nikolas B. Harbord, Peter Hewins, Jonathan Himmelfarb, Norman K. Hollenberg, Enyu Imai, Yoshitaka Isaka, Hye Ryoun Jang, David Jayne, Jay R. Kaluvapalle, Kamel S. Kamel, Suraj Kapa, Norman M. Kaplan, Joana E. Kist-van Holthe, Mary E. Klotman, Paul E. Klotman, Jeffrey B. Kopp, Lawrence R. Krakoff, Aaron C. Lentz, Susan M. Lerner, Jerrold S. Levine, Jeremy B. Levy, Edmund J. Lewis, Julia B. Lewis, Shih-Hua Lin, Francisco Llach, Friedrich C. Luft, Samuel J. Mann, Kevin J. Martin, Tahsin Masud, Roy O. Mathew, W. Scott McDougal, Michael McKusick, Ravindra L. Mehta, Luigi Minetti, Adam M. Mirot, William E. Mitch, Alvin H. Moss, Barbara Murphy, Mitra K. Nadim, Eric G. Neilson, Elizabeth H. Nora, Marina Noris, Pouneh Nouri, Man S. Oh, Yvonne M. O-Meara, Biff F. Palmer, Vasilios Papademetriou, Patrick S. Parfrey, Manish P. Patel, Marie-Noëlle Pépin, William D. Plant, Charles D. Pusey, Rizwan A. Qazi, Hamid Rabb, Brian D. Radbill, Frederic F. Rahbari-Oskoui, Andrew J. Rees, Giuseppe Remuzzi, Zaccaria Ricci, Eberhard Ritz, Nancy M. Rodig, Claudio Ronco, Robert H. Rubin, Robert J. Rubin, Piero Ruggenenti, David J. Salant, Paul W. Sanders, Caroline O.S. Savage, Mohamed H. Sayegh, Arrigo Schieppati, Bernd Schröppel, Gerald Schulman, Douglas G. Shemin, Baha M. Sibai, Sandra Silva, Karen D. Sims, James P. Smith, Richard J.H. Smith, Michael J.G. Somers, Virend K. Somers, Maarten W. Taal, Yoshitsugu Takabatake, Eric N. Taylor, Edward G. Tessier, Stephen C. Textor, Joshua M. Thurman, Nina E. Tolkoff-Rubin, Robert D. Toto, A. Neil Turner, Robert Unwin, Joseph A. Vassalotti, Gloria Lena Vega, John P. Vella, Meryl Waldman, Ravinder K. Wali, Christoph Wanner, William L. Whittier, Christopher S. Wilcox, John D. Williams, James F. Winchester, Christina M. Wyatt, Jane Y. Yeun, Alan S.L. Yu, and Carmine Zoccali

Published
2008
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12. Importance of secondary organic aerosol formation of α-pinene, limonene, and m-cresol comparing day- and nighttime radical chemistry

Author

A. Mutzel, Y. Zhang, O. Böge, M. Rodigast, A. Kolodziejczyk, X. Wang, and H. Herrmann

Subjects
Physics, QC1-999, Chemistry, QD1-999
Abstract

The oxidation of biogenic and anthropogenic compounds leads to the formation of secondary organic aerosol mass (SOA). The present study aims to investigate α-pinene, limonene, and m-cresol with regards to their SOA formation potential dependent on relative humidity (RH) under night- (NO3 radicals) and daytime conditions (OH radicals) and the resulting chemical composition. It was found that SOA formation potential of limonene with NO3 under dry conditions significantly exceeds that of the OH-radical reaction, with SOA yields of 15–30 % and 10–21 %, respectively. Additionally, the nocturnal SOA yield was found to be very sensitive towards RH, yielding more SOA under dry conditions. In contrast, the SOA formation potential of α-pinene with NO3 slightly exceeds that of the OH-radical reaction, independent from RH. On average, α-pinene yielded SOA with about 6–7 % from NO3 radicals and 3–4 % from OH-radical reaction. Surprisingly, unexpectedly high SOA yields were found for m-cresol oxidation with OH radicals (3–9 %), with the highest yield under elevated RH (9 %), which is most likely attributable to a higher fraction of 3-methyl-6-nitro-catechol (MNC). While α-pinene and m-cresol SOA was found to be mainly composed of water-soluble compounds, 50–68 % of nocturnal SOA and 22–39 % of daytime limonene SOA are water-insoluble. The fraction of SOA-bound peroxides which originated from α-pinene varied between 2 and 80 % as a function of RH. Furthermore, SOA from α-pinene revealed pinonic acid as the most important particle-phase constituent under day- and nighttime conditions with a fraction of 1–4 %. Other compounds detected are norpinonic acid (0.05–1.1 % mass fraction), terpenylic acid (0.1–1.1 % mass fraction), pinic acid (0.1–1.8 % mass fraction), and 3-methyl-1,2,3-tricarboxylic acid (0.05–0.5 % mass fraction). All marker compounds showed higher fractions under dry conditions when formed during daytime and showed almost no RH effect when formed during night.

Published
2021
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13. Development of a protocol for the auto-generation of explicit aqueous-phase oxidation schemes of organic compounds

Author

P. Bräuer, C. Mouchel-Vallon, A. Tilgner, A. Mutzel, O. Böge, M. Rodigast, L. Poulain, D. van Pinxteren, R. Wolke, B. Aumont, and H. Herrmann

Subjects
Physics, QC1-999, Chemistry, QD1-999
Abstract

This paper presents a new CAPRAM–GECKO-A protocol for mechanism auto-generation of aqueous-phase organic processes. For the development, kinetic data in the literature were reviewed and a database with 464 aqueous-phase reactions of the hydroxyl radical with organic compounds and 130 nitrate radical reactions with organic compounds has been compiled and evaluated. Five different methods to predict aqueous-phase rate constants have been evaluated with the help of the kinetics database: gas–aqueous phase correlations, homologous series of various compound classes, radical reactivity comparisons, Evans–Polanyi-type correlations, and structure–activity relationships (SARs). The quality of these prediction methods was tested as well as their suitability for automated mechanism construction. Based on this evaluation, SARs form the basis of the new CAPRAM–GECKO-A protocol. Evans–Polanyi-type correlations have been advanced to consider all available H atoms in a molecule besides the H atoms with only the weakest bond dissociation enthalpies (BDEs). The improved Evans–Polanyi-type correlations are used to predict rate constants for aqueous-phase NO3 and organic compounds reactions. Extensive tests have been performed on essential parameters and on highly uncertain parameters with limited experimental data. These sensitivity studies led to further improvements in the new CAPRAM–GECKO-A protocol but also showed current limitations. Biggest uncertainties were observed in uptake processes and the estimation of Henry's law coefficients as well as radical chemistry, in particular the degradation of alkoxy radicals. Previous estimation methods showed several deficits, which impacted particle growth. For further evaluation, a 1,3,5-trimethylbenzene oxidation experiment has been performed in the aerosol chamber “Leipziger Aerosolkammer” (LEAK) at high relative humidity conditions and compared to a multiphase mechanism using the Master Chemical Mechanism (MCMv3.2) in the gas phase and using a methylglyoxal oxidation scheme of about 600 reactions generated with the new CAPRAM–GECKO-A protocol in the aqueous phase. While it was difficult to evaluate single particle constituents due to concentrations close to the detection limits of the instruments applied, the model studies showed the importance of aqueous-phase chemistry in respect to secondary organic aerosol (SOA) formation and particle growth. The new protocol forms the basis for further CAPRAM mechanism development towards a new version 4.0. Moreover, it can be used as a supplementary tool for aerosol chambers to design and analyse experiments of chemical complexity and help to understand them on a molecular level.

Published
2019
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14. A quantification method for heat-decomposable methylglyoxal oligomers and its application on 1,3,5-trimethylbenzene SOA

Author

M. Rodigast, A. Mutzel, and H. Herrmann

Subjects
Physics, QC1-999, Chemistry, QD1-999
Abstract

Methylglyoxal forms oligomeric compounds in the atmospheric aqueous particle phase, which could establish a significant contribution to the formation of aqueous secondary organic aerosol (aqSOA). Thus far, no suitable method for the quantification of methylglyoxal oligomers is available despite the great effort spent for structure elucidation. In the present study a simplified method was developed to quantify heat-decomposable methylglyoxal oligomers as a sum parameter. The method is based on the thermal decomposition of oligomers into methylglyoxal monomers. Formed methylglyoxal monomers were detected using PFBHA (o-(2,3,4,5,6-pentafluorobenzyl)hydroxylamine hydrochloride) derivatisation and gas chromatography–mass spectrometry (GC/MS) analysis. The method development was focused on the heating time (varied between 15 and 48 h), pH during the heating process (pH = 1–7), and heating temperature (50, 100 °C). The optimised values of these method parameters are presented. The developed method was applied to quantify heat-decomposable methylglyoxal oligomers formed during the OH-radical oxidation of 1,3,5-trimethylbenzene (TMB) in the Leipzig aerosol chamber (LEipziger AerosolKammer, LEAK). Oligomer formation was investigated as a function of seed particle acidity and relative humidity. A fraction of heat-decomposable methylglyoxal oligomers of up to 8 % in the produced organic particle mass was found, highlighting the importance of those oligomers formed solely by methylglyoxal for SOA formation. Overall, the present study provides a new and suitable method for quantification of heat-decomposable methylglyoxal oligomers in the aqueous particle phase.

Published
2017
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15. A new source of methylglyoxal in the aqueous phase

Author

M. Rodigast, A. Mutzel, J. Schindelka, and H. Herrmann

Subjects
Physics, QC1-999, Chemistry, QD1-999
Abstract

Carbonyl compounds are ubiquitous in atmospheric multiphase system participating in gas, particle, and aqueous-phase chemistry. One important compound is methyl ethyl ketone (MEK), as it is detected in significant amounts in the gas phase as well as in cloud water, ice, and rain. Consequently, it can be expected that MEK influences the liquid-phase chemistry. Therefore, the oxidation of MEK and the formation of corresponding oxidation products were investigated in the aqueous phase. Several oxidation products were identified from the oxidation with OH radicals, including 2,3-butanedione, hydroxyacetone, and methylglyoxal. The molar yields were 29.5 % for 2,3-butanedione, 3.0 % for hydroxyacetone, and 9.5 % for methylglyoxal. Since methylglyoxal is often related to the formation of organics in the aqueous phase, MEK should be considered for the formation of aqueous secondary organic aerosol (aqSOA). Based on the experimentally obtained data, a reaction mechanism for the formation of methylglyoxal has been developed and evaluated with a model study. Besides known rate constants, the model contains measured photolysis rate constants for MEK (kp = 5 × 10−5 s−1), 2,3-butanedione (kp = 9 × 10−6 s−1), methylglyoxal (kp = 3 × 10−5 s−1), and hydroxyacetone (kp = 2 × 10−5 s−1). From the model predictions, a branching ratio of 60 /40 for primary/secondary H-atom abstraction at the MEK skeleton was found. This branching ratio reproduces the experiment results very well, especially the methylglyoxal formation, which showed excellent agreement. Overall, this study demonstrates MEK as a methylglyoxal precursor compound for the first time.

Published
2016
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16. Characterisation and optimisation of a sample preparation method for the detection and quantification of atmospherically relevant carbonyl compounds in aqueous medium

Author

M. Rodigast, A. Mutzel, Y. Iinuma, S. Haferkorn, and H. Herrmann

Subjects
Environmental engineering, TA170-171, Earthwork. Foundations, TA715-787
Abstract

Carbonyl compounds are ubiquitous in the atmosphere and either emitted primarily from anthropogenic and biogenic sources or they are produced secondarily from the oxidation of volatile organic compounds. Despite a number of studies about the quantification of carbonyl compounds a comprehensive description of optimised methods is scarce for the quantification of atmospherically relevant carbonyl compounds. The method optimisation was conducted for seven atmospherically relevant carbonyl compounds including acrolein, benzaldehyde, glyoxal, methyl glyoxal, methacrolein, methyl vinyl ketone and 2,3-butanedione. O-(2,3,4,5,6-pentafluorobenzyl)hydroxylamine hydrochloride (PFBHA) was used as derivatisation reagent and the formed oximes were detected by gas chromatography/mass spectrometry (GC/MS). With the present method quantification can be carried out for each carbonyl compound originating from fog, cloud and rain or sampled from the gas- and particle phase in water. Detection limits between 0.01 and 0.17 μmol L−1 were found, depending on carbonyl compounds. Furthermore, best results were found for the derivatisation with a PFBHA concentration of 0.43 mg mL−1 for 24 h followed by a subsequent extraction with dichloromethane for 30 min at pH = 1. The optimised method was evaluated in the present study by the OH radical initiated oxidation of 3-methylbutanone in the aqueous phase. Methyl glyoxal and 2,3-butanedione were found to be oxidation products in the samples with a yield of 2% for methyl glyoxal and 14% for 2,3-butanedione after a reaction time of 5 h.

Published
2015
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17. Overview of JET results

Author

F. Romanelli, F. Laxaback, I. Abel, V. Afanesyev, G. Agarici, K. M. Aggarwal, M. Airila, R. Akers, T.h. Alarcon, A. Alexeev, A. Alfier, P. Allan, S. Almaviva, A. Alonso, M. Alonso, B. Alper, H. Altmann, D. Alves, V. Amosov, G. Anda, F. Andersson, E. Andersson Sund́en, V. Andreev, Y. Andrew, M. Angelone, M. Anghel, A. Anghel, C. Angioni, G. Apruzzese, N. Arcis, P. Arena, A. Argouarch, M. Ariola, A. Armitano, R. Armstrong, G. Arnoux, S. Arshad, G. Artaserse, J. F. Artaud, A. Ash, E. Asp, O. Asunta, C. V. Atanasiu, G. Atkins, M. D. Axton, C. Ayres, A. Baciero, V. Bailescu, B. Baiocchi, R. A. Baker, I. Balboa, C. Balorin, N. Balshaw, J. W. Banks, Y. F. Baranov, D. Barbier, I. L. Barlow, M. A. Barnard, R. Barnsley, L. Barrena, L. Barrera, M. Baruzzo, V. Basiuk, G. Bateman, P. Batistoni, N. Baumgarten, L. Baylor, B. Bazylev, P. S. Beaumont, K. Beausang, M. B́ecoulet, N. Bekris, M. Beldishevski, A. C. Bell, F. Belli, M. Bellinger, P. S. A. Belo, ́.E. Belonohy, P. E. Bennett, N. A. Benterman, G. Berger By, H. Bergsåker, H. Berk, J. Bernardo, B. Bertrand, M. N. A. Beurskens, B. Bieg, B. Bienkowska, T. Biewer, T. M. Biewer, M. Bigi, R. Bilato, J. Bird, J. Bizarro, T. R. Blackman, P. Blanchard, E. Blanco, J. Blum, V. Bobkov, A. Boboc, D. Boilson, I. Bolshakova, T. Bolzonella, L. Boncagni, G. Bonheure, X. Bonnin, D. Borba, A. Borthwick, A. Botrugno, C. Boulbe, F. Bouquey, C. Bourdelle, K. v. Bovert, M. Bowden, T. Boyce, H. J. Boyer, A. Bozhenkov, R. J. Brade, J. M. A. Bradshaw, J. Braet, V. Braic, G. C. Braithwaite, C. Brault, H. Braune, B. Breizman, S. Bremond, P. D. Brennan, A. Brett, J. Breue, S. Brezinsek, M. D. J. Bright, F. Briscoe, M. Brix, M. Brombin, B. C. Brown, D. P. D. Brown, A. Bruschi, J. Brzozowski, J. Bucalossi, M. A. Buckley, T. Budd, R. Budny, R. V. Budny, P. Bunting, P. Buratti, G. Burcea, P. R. Butcher, R. J. Buttery, R. Caç̃ao, G. Calabr`o, C. P. Callaghan, J. P. Caminade, P. G. Camp, D. C. Campling, J. Canik, B. Cannas, A. J. Capel, P. J. Card, A. Cardinali, T. Carlstrom, P. Carman, D. Carralero, L. Carraro, T. Carter, B. B. Carvalho, P. Carvalho, A. Casati, C. Castaldo, J. Caughman, R. Cavazzana, M. Cavinato, M. Cecconello, F. E. Cecil, A. Cenedese, C. Centioli, R. Cesario, C. D. Challis, M. Chandler, C. Chang, A. Chankin, I. T. Chapman, D. J. Child, P. Chiru, G. Chitarin, I. Chugonov, I. Chugunov, D. Ciric, F. Clairet, R. H. Clarke, R. Clay, M. Clever, J. P. Coad, P. A. Coates, V. Cocilovo, S. Coda, R. Coelho, J. Coenen, I. Coffey, L. Colas, M. Cole, S. Collins, S. Combs, J. Compan, J. E. Conboy, S. Conroy, N. Cook, S. P. Cook, D. Coombs, S. R. Cooper, Y. Corre, G. Corrigan, S. Cortes, D. Coster, G. F. Counsell, X. Courtois, M. Cox, T. Craciunescu, S. Cramp, F. Crisanti, O. Croft, K. Crombe, B. J. Crowley, N. Cruz, L. Cupido, M. Curuia, R. A. Cusack, A. Czarnecka, S. Dalley, E. T. Daly, A. Dalziel, D. Darrow, O. David, N. Davies, J. J. Davis, I. E. Day, C. Day, R. De Angelis, G. deArcas, M. R. de Baar, E. delaCal, E. de la Luna, J. L. de Pablos, G. De Temmerman, P. C. de Vries, F. Degli Agostini, E. Delabie, D. del Castillo Negrete, L. Delpech, G. Denisov, A. J. Denyer, R. F. Denyer, S. Devaux, P. Devynck, L. Di Matteo, L. DiPace, P. J. Dirken, A. Dnestrovskiy, D. Dodt, K. Dominiczak, S. E. Dorling, D. Douai, A. P. Down, P. T. Doyle, J. R. Drake, T. Dreischuh, V. Drozdov, P. Dumortier, D. Dunai, I. Duran, F. Durodíe, K. Dylst, R. Eaton, T. Edlington, A. M. Edwards, D. T. Edwards, P. K. Edwards, T.h. Eich, A. Ekedahl, T. Elevant, A. Elfimov, B. Ellingboe, C. G. Elsmore, B. Emmoth, G. Ericsson, L. G. Eriksson, A. Eriksson, B. Esposito, H. G. Esser, T. Estrada, E. A. Evangelidis, G. E. Evans, G. D. Ewart, D. T. Ewers, G. Falchetto, D. Falie, J. G. A. Fanthome, D. Farina, J. W. Farthing, A. Fasoli, B. Faugeras, N. Fedorczak, R. C. Felton, C. Fenzi, H. Fernandes, J. A. Ferreira, J. Ferreira, J. Ferron, J. A. Fessey, L. Figini, A. Figueiredo, J. Figueiredo, P. Finburg, K. H. Finken, U. Fischer, N. Fitzgerald, J. Flanagan, C. Fleming, A. Fonseca, A. D. Forbes, O. Ford, A. Formisano, D. Fraboulet, R. J. Francis, L. Frassinetti, R. Fresa, J. P. Friconneau, D. Frigione, J. C. Fuchs, K. Fullard, W. Fundamenski, M. Furno Palumbo, J. Gafert, K. Ǵal, R. Galṽao, S. Garavaglia, X. Garbet, J. Garcia, M. Gar cia Munoz, W. Gardner, P. Garibaldi, D. Garnier, L. Garzotti, M. Gatu Johnson, P. Gaudio, E. Gauthier, J. W. Gaze, D. F. Gear, J. Gedney, S. J. Gee, M. Gelfusa, E. Genangeli, S. Gerasimov, A. Geraud, T. Gerbaud, M. Gherendi, N. Ghirelli, J. C. Giacalone, L. Giacomelli, C. S. Gibson, C. Gil, S. J. Gilligan, C. G. Gimblett, D. Gin, E. Giovannozzi, C. Giroud, G. Giruzzi, S. Glowacz, J. Godwin, J. K. Goff, P. Gohil, V. Goloborod’ko, B. Gonçalves, M. Goniche, S. Gonzales, S. M. Gonźalezde Vicente, A. Goodyear, N. Gorelenkov, G. Gorini, R. Goulding, B. Graham, D. Graham, M. E. Graham, G. Granucci, J. Graves, N. R. Green, H. Greuner, E. Grigore, F. S. Griph, C. Grisolia, G. Gros, G. Grossetti, M. Groth, S. Gr̈unhagen, M. P. Gryaznevich, R. Guirlet, B. Gulejova, J. Gunn, A. Gupta, P. Guzdar, P. Hacek, L. J. Hackett, S. Hacquin, B. Haist, A. Hakola, S. J. Hall, S. P. HallworthCook, D. T. Hamilton, H. Han, R. C. Handley, S. Harding, J. D. W. Harling, D. Harting, M. J. Harvey, T. D. V. Haupt, E. Havlickova, N. C. Hawkes, R. Hawryluk, J. H. Hay, N. Hayashi, P. W. Haydon, I. R. Hayward, S. Hazel, P. J. L. Heesterman, W. Heidbrink, J. Heikkinen, C. Hellesen, T. Hellsten, O. N. Hemming, T. C. Hender, M. Henderson, C. Hennig, V. Hennion, C. Hidalgo, S. Higashijima, J. W. Hill, M. Hill, K. Hill, J. Hillairet, D. Hillis, T. Hirai, M. Hitchin, J. Hobirk, C. Hogan, C. H. A. Hogben, G. M. D. Hogeweij, I. C. Hollingham, R. Holyaka, D. A. Homfray, G. Honeyands, S. H. Hong, C. Hopf, B. A. Horn, A. R. Horton, L. D. Horton, S. P. Hotchin, M. R. Hough, W. Houlberg, D. F. Howell, M. Hron, A. Huber, T. M. Huddleston, Z. Hudson, M. Hughes, M. Ḧuhnerbein, C. C. Hume, A. J. Hunt, C. L. Hunter, T. S. Hutchinson, S. Huygen, G. Huysmans, V. Hyn̈onen, S. Ide, R. Igreja, C. Illescas, F. Imbeaux, D. Ivanova, E. Ivings, S. Jachmich, G. Jackson, P. Jacquet, K. Jakubowska, M. Jakubowski, P. V. James, R. J. E. Jaspers, S. Jednorog, I. Jenkins, M. A. C. Jennison, C. Jeskins, O. Jin Kwon, E. Joffrin, M. F. Johnson, R. Johnson, T. Johnson, D. Jolovic, V. Jonauskas, E. M. Jones, G. Jones, H. D. Jones, T. T. C. Jones, M. Jouvet, C. Juṕen, I. Kachtchouk, J. Kaczmarczyk, A. Kallenbach, J. K̈allne, D. Kalupin, S. Ḱalvin, G. Kamelander, R. Kamendje, A. Kappatou, S. Karttunen, W. Kasparek, I. Katramados, M. Kaufmann, G. Kaveney, A. S. Kaye, M. J. Kear, D. L. Keeling, D. Kelliher, M. Kempenaars, P. Khilar, N. G. Kidd, M. Kiisk, K. M. Kim, R. F. King, D. J. Kinna, V. Kiptily, G. Kirnev, N. Kirneva, K. Kirov, A. Kirschner, R. Kisielius, D. Kislov, G. Kiss, T. Kiviniemi, G. Kizane, A. Klein, A. Klix, M. Knaup, K. Kneuper, H. Kneupner, P. J. Knight, S. J. Knipe, M. Kocan, F. K̈ochl, G. Kocsis, C. Konz, T. Koppitz, A. Korotkov, H. R. Koslowski, V. Kotov, M. D. Kovari, K. Kovarik, G. Kramer, A. Krasilnikov, V. Krasilnikov, S. Kraus, A. Kreter, K. Krieger, A. Kritz, Y. Krivchenkov, U. Kruezi, M. Krychowiak, S. Krylov, I. Ksiazek, M. Kubic, S. Kuhn, W. K̈uhnlein, T. Kurki Suonio, A. Kurowski, B. Kuteev, A. Kuyanov, R. La Haye, M. Laan, C. Labate, A. Lachichi, N. Lam, P. Lang, M. T. Large, I. Lassiwe, J. R. Last, K. D. Lawson, M. Laxåback, R. A. Layne, E. Lazzaro, F. LeGuern, B. LeBlanc, H. J. Leggate, M. Lehnen, M. Leigheb, I. Lengar, M. Lennholm, E. Lerche, C. N. Lescure, Y. Li, A. Li Puma, Y. Liang, J. Likonen, Y. Lin, J. Linke, S. A. Linstead, B. Lipshultz, X. Litaudon, A. G. Litvak, Y. Liu, T. Loarer, A. Loarte, R. C. Lobel, P. J. Lomas, F. D. Long, J. L̈onnroth, D. J. Looker, J. Lopez, P.h. Lotte, M. J. Loughlin, A. B. Loving, C. Lowry, T. Luce, R. M. A. Lucock, A. Lukanitsa, A. M. Lungu, C. P. Lungu, A. Lyssoivan, P. Macheta, A. S. Mackenzie, M. Macrae, G. Maddaluno, G. P. Maddison, J. Madsen, P. Maget, C. Maggi, H. Maier, J. Mailloux, M. Makowski, C. J. Manning, M. Mansfield, M. E. Manso, P. Mantica, M. Mantsinen, M. Maraschek, C. Marchetto, M. A. Marchitti, M. Mardenfeld, J. L. Marechal, M. Marinelli, A. Marinoni, M. Marinucci, J. M̈arki, D. Marocco, C. A. Marren, D. Martin, D. L. Martin, G. Martin, Y. Martin, J. R. Mart́ın Soĺıs, K. Masaki, A. Masiello, M. Maslov, C. Maszl, A. Matilal, M. Mattei, G. F. Matthews, F. Maviglia, C. R. May, M. Mayer, M. L. Mayoral, D. Mazon, C. Mazzotta, E. Mazzucato, P. McCarthy, K. G. McClements, K. McCormick, P. A. McCullen, D. McCune, D. C. McDonald, R. Mcgregor, J. P. Mckivitt, A. Meakins, F. Medina, A. G. Meigs, M. Menard, L. Meneses, S. Menmuir, I. R. Merrigan, P.h. Mertens, A. Messiaen, H. Meyer, M. Miele, P. Migliucci, A. G. Miller, S. F. Mills, J. J. Milnes, K. Min Kim, T. Mindham, F. Mirizzi, E. Mirones, M. Mironov, R. Mitteau, J. Mlynar, P. Mollard, I. Monakhov, P. Monier Garbet, R. Mooney, S. Moradi, D. Moreau, P.h. Moreau, L. Moreira, A. Morgan, P. D. Morgan, C. Morlock, A. Moro, A. W. Morris, G. L. Mort, C. Mrozek, A. Mueck, H. W. M̈uller, M. Murakami, A. Murari, I. Mustata, F. Nabais, E. Nardon, G. Nash, V. Naulin, M. F. F. Nave, R. Nazikian, I. Nedzelski, C. R. Negus, J. D. Neilson, A. Neto, R. Neu, O. Neubauer, G. J. Newbert, M. Newman, K. J. Nicholls, A. Nicolai, L. Nicolas, P. Nieckchen, P. Nielsen, A. H. Nielsen, S. K. Nielsen, G. Nielson, J. Nieto, M. P. S. Nightingale, C. Noble, M. Nocente, M. Nora, H. Nordman, M. Norman, J. M. Noterdaeme, S. Nowak, I. Nunes, F. Ognissanto, T. O’Gorman, S. Olariu, A. Oleynikov, M. O’Mullane, J. Ongena, F. Orsitto, O. I. Oswuigwe, M. Ottaviani, N. Oyama, D. Pacella, K. Paget, S. Palazzo, J. Pamela, S. Pamela, R. Panek, L. Pangione, A. Panin, T.h. Panis, A. Pankin, A. Pantea, V. Parail, T.h. Parisot, A. Parkin, A. Parsloe, B. T. Parsons, R. Pasqualotto, P. Pastor, R. Paterson, M. K. Paul, D. Peach, R. J. H. Pearce, B. J. Pearson, I. J. Pearson, L. C. Pedrick, M. A. Pedrosa, B. Pegourie, R. Pereira, E. Perelli Cippo, G. Pereverzev, A. Perevezentsev, C.h. PerezvonThun, V. Pericoli Ridolfini, A. Perona, Y. Perrot, S. Peruzzo, S. Peschanyy, G. Petravich, L. Petrizzi, V. Petrov, V. Petrzilka, V. Philipps, G. Piazza, F. Piccolo, A. Pietropaolo, M. Pillon, S. D. Pinches, T. Pinna, G. Pintsuk, P. Piovesan, F. Pisano, R. Pitts, B. Plaum, V. Plyusnin, M. Polasik, F. M. Poli, N. Pomaro, O. Pompilian, L. Poncet, P. J. Pool, S. Popovichev, F. Porcelli, M. T. Porfiri, C. Portafaix, A. Pospieszczyk, G. Possnert, G. Prestopino, P. Prior, R. Prokopowicz, I. Proverbio, R. Pugno, M. E. Puiatti, K. Purahoo, V. Pustovitov, T.h. P̈utterich, D. P̈uttmann Kneupner, E. Rachlew, R. Rademaker, T. Rafiq, M. S. J. Rainford, G. Ramogida, K. Rantam̈aki, J. Rapp, J. J. Rasmussen, G. Ratt́a, G. Ravera, M. Reich, R. Reichle, D. Reiser, R. Reiss, D. Reiter, D. Rendell, C. Reux, G. Rewoldt, T. T. Ribeiro, V. Riccardo, D. Richards, F. Rigollet, F. G. Rimini, L. Rios, M. Riva, J. E. C. Roberts, R. J. Robins, D. S. Robinson, S. A. Robinson, D. W. Robson, H. Roche, M. R̈odig, N. Rodionov, V. Rohde, A. Rolfe, M. Romanelli, A. Romano, J. Romero, E. Ronchi, S. Rosanvallon, C.h. Roux, S. Rowe, M. Rubel, L. Ruchko, M. Ruiz, C. Ruset, M. Russell, A. Ruth, L. Ryc, A. Rydzy, F. Ryter, J. Rzadkiewicz, S. Saarelma, F. Sabathier, R. Sabot, S. Sadakov, P. Sagar, G. Saibene, A. Saille, F. Saint Laurent, A. Salmi, R. Salomaa, F. Salzedas, U. Samm, P. Sanchez, S. Sanders, S. G. Sanders, G. Sandford, K. Sandland, P. Sandquist, D. E. G. Sands, M. I. K. Santala, F. Sartori, R. Sartori, O. Sauter, A. Savelyev, A. Savtchkov, S. C. Scales, A. Scarabosio, N. Schaefer, C.h. Schlatter, V. Schmidt, A. Schmidt, O. Schmitz, S. Schmuck, M. Schneider, M. Scholz, K. Scḧopf, B. Schweer, J. Schweinzer, B. Scott, M. Seki, L. Semeraro, A. Semerok, G. Sergienko, F. Serra, M. Sertoli, M. M. J. Shannon, S. E. Sharapov, S. R. Shaw, A. Shevelev, R. Sievering, C. A. Silva, P. A. Simmons, A. Simonetto, D. Simpson, S. Sipila, A. C. C. Sips, A. Sirinelli, H. Sj̈ostrand, D. Skopintsev, K. S.l.a.b.k.o.w.s.k.a., P. G. Smith, J. Snipes, L. Snoj, S. Snyder, S. Soare, E. R. Solano, S. Soldatov, A. Soleto, W. Solomon, C. Soltane, P. Sonato, A. Sopplesa, A. Sorrentino, J. Sousa, C. B. C. Sowden, C. Sozzi, P. Sp̈ah, T. Spelzini, J. Spence, F. Spineanu, P. Spuig, A. Sẗabler, R. D. Stagg, M. F. Stamp, V. Stancalie, P. Stangeby, C. Stan Sion, D. E. Starkey, M. J. Stead, A. V. Stephen, A. L. Stevens, J. Stober, R. B. Stokes, D. Stork, D. Stoyanov, J. Strachan, P. Strand, M. Stransky, D. Strauss, D. Strintzi, W. Studholme, Y. SuNa, F. Subba, H. P. Summers, Y. Sun, C. Surdu Bob, E. Surrey, D. J. Sutton, J. Svensson, D. Swain, B. D. Syme, I. D. Symonds, T. Szepesi, A. Szydlowski, F. Tabares, V. Takalo, H. Takenaga, T. Tala, A. R. Talbot, C. Taliercio, C. Tame, G. Tardini, M. Tardocchi, L. Taroni, G. Telesca, A. Terra, A. O. Terrington, D. Testa, J. M. Theis, J. D. Thomas, P. D. Thomas, P. R. Thomas, V. K. Thompson, H. Thomsen, C. Thomser, A. Thyagaraja, P. A. Tigwell, I. Tiseanu, R. Tivey, J. M. Todd, T. N. Todd, M. Z. Tokar, S. Tosti, P. Trabuc, J. M. Travere, W. Treutterer, P. Trimble, A. Trkov, E. Trukhina, M. Tsalas, H. Tsige Tamirat, E. Tsitrone, D. Tskhakaya jun, O. Tudisco, S. Tugarinov, M. M. Turner, G. Turri, S. G. J. Tyrrell, N. Umeda, B. Unterberg, H. Urano, A. J. Urquhart, I. Uytdenhouwen, A. Vaccaro, A. P. Vadgama, G. Vagliasindi, D. Valcarcel, M. Valisa, J. Vallory, M. Valovic, D. Van Eester, B. van Milligen, G. J. van Rooij, C. A. F. Varandas, S. Vartanian, V. Vdovin, J. Vega, G. Verdoolaege, J. M. Verger, L. Vermare, C. Verona, T.h. Versloot, M. Vervier, J. Vicente, S. Villari, E. Villedieu, F. Villone, J. E. Vince, G. J. Vine, B. Viola, E. Vitale, R. Vitelli, M. Vlad, I. Voitsekhovitch, M. Vrancken, K. Vulliez, C. W. F. Waldon, M. Walker, M. J. Walsh, J. Waterhouse, M. L. Watkins, M. J. Watson, T. Wauters, M. W. Way, C. R. Webb, J. Weiland, H. Weisen, M. Weiszflog, R. Wenninger, A. T. West, J. M. Weulersse, B. Weyssow, M. R. Wheatley, A. D. Whiteford, A. M. Whitehead, A. G. Whitehurst, A. M. Widdowson, R. C. Wieggers, C. Wiegmann, S. Wiesen, A. Wilson, D. Wilson, D. J. Wilson, H. R. Wilson, M. Wischmeier, D. M. Witts, R. C. Wolf, J. Wolowski, P. Woscov, G. M. Wright, J. Wright, G. S. Xu, V. Yavorskij, V. Yerashok, J. Yorkshades, C. Young, D. Young, I. D. Young, X. Yuhong, L. Zabeo, A. Zabolotsky, L. Zaccarian, R. Zagorski, F. S. Zaitsev, S. Zajac, L. Zakharov, R. Zanino, V. Zaroschi, K. D. Zastrow, I. Zatz, B. Zefran, W. Zeidner, M. Zerbini, T. Zhang, Y. Zhu, E. Zilli, O. Zimmermann, V. Zoita, S. Zoletnik, W. Zwingman, JET EFDA Contributors, ALBANESE, Raffaele, AMBROSINO, GIUSEPPE, BELLIZIO, TERESA, CARANNANTE, GIUSEPPE, COCCORESE, VINCENZO, DE TOMMASI, GIANMARIA, MIANO, GIOVANNI, PIRONTI, ALFREDO, QUERCIA, ANTONIO, RUBINACCI, GUGLIELMO, J., Pamela, EMILIA R., Solano, AND JET EFDA, Contributor, J. M., Adam, G., Agarici, M., Agarici, H., Akhter, Albanese, Raffaele, Romanelli, F., Laxaback, F., Abel, I., Afanesyev, V., Agarici, G., Aggarwal, K. M., Airila, M., Akers, R., Alarcon, T. h., Alexeev, A., Alfier, A., Allan, P., Almaviva, S., Alonso, A., Alonso, M., Alper, B., Altmann, H., Alves, D., Ambrosino, Giuseppe, Amosov, V., Anda, G., Andersson, F., Andersson Sund́en, E., Andreev, V., Andrew, Y., Angelone, M., Anghel, M., Anghel, A., Angioni, C., Apruzzese, G., Arcis, N., Arena, P., Argouarch, A., Ariola, M., Armitano, A., Armstrong, R., Arnoux, G., Arshad, S., Artaserse, G., Artaud, J. F., Ash, A., Asp, E., Asunta, O., Atanasiu, C. V., Atkins, G., Axton, M. D., Ayres, C., Baciero, A., Bailescu, V., Baiocchi, B., Baker, R. A., Balboa, I., Balorin, C., Balshaw, N., Banks, J. W., Baranov, Y. F., Barbier, D., Barlow, I. L., Barnard, M. A., Barnsley, R., Barrena, L., Barrera, L., Baruzzo, M., Basiuk, V., Bateman, G., Batistoni, P., Baumgarten, N., Baylor, L., Bazylev, B., Beaumont, P. S., Beausang, K., B́ecoulet, M., Bekris, N., Beldishevski, M., Bell, A. C., Belli, F., Bellinger, M., Bellizio, Teresa, Belo, P. S. A., Belonohy, ́. E., Bennett, P. E., Benterman, N. A., Berger By, G., Bergsåker, H., Berk, H., Bernardo, J., Bertrand, B., Beurskens, M. N. A., Bieg, B., Bienkowska, B., Biewer, T., Biewer, T. M., Bigi, M., Bilato, R., Bird, J., Bizarro, J., Blackman, T. R., Blanchard, P., Blanco, E., Blum, J., Bobkov, V., Boboc, A., Boilson, D., Bolshakova, I., Bolzonella, T., Boncagni, L., Bonheure, G., Bonnin, X., Borba, D., Borthwick, A., Botrugno, A., Boulbe, C., Bouquey, F., Bourdelle, C., Bovert, K. v., Bowden, M., Boyce, T., Boyer, H. J., Bozhenkov, A., Brade, R. J., Bradshaw, J. M. A., Braet, J., Braic, V., Braithwaite, G. C., Brault, C., Braune, H., Breizman, B., Bremond, S., Brennan, P. D., Brett, A., Breue, J., Brezinsek, S., Bright, M. D. J., Briscoe, F., Brix, M., Brombin, M., Brown, B. C., Brown, D. P. D., Bruschi, A., Brzozowski, J., Bucalossi, J., Buckley, M. A., Budd, T., Budny, R., Budny, R. V., Bunting, P., Buratti, P., Burcea, G., Butcher, P. R., Buttery, R. J., Caç̃ao, R., Calabr`o, G., Callaghan, C. P., Caminade, J. P., Camp, P. G., Campling, D. C., Canik, J., Cannas, B., Capel, A. J., Carannante, Giuseppe, Card, P. J., Cardinali, A., Carlstrom, T., Carman, P., Carralero, D., Carraro, L., Carter, T., Carvalho, B. B., Carvalho, P., Casati, A., Castaldo, C., Caughman, J., Cavazzana, R., Cavinato, M., Cecconello, M., Cecil, F. E., Cenedese, A., Centioli, C., Cesario, R., Challis, C. D., Chandler, M., Chang, C., Chankin, A., Chapman, I. T., Child, D. J., Chiru, P., Chitarin, G., Chugonov, I., Chugunov, I., Ciric, D., Clairet, F., Clarke, R. H., Clay, R., Clever, M., Coad, J. P., Coates, P. A., Coccorese, Vincenzo, Cocilovo, V., Coda, S., Coelho, R., Coenen, J., Coffey, I., Colas, L., Cole, M., Collins, S., Combs, S., Compan, J., Conboy, J. E., Conroy, S., Cook, N., Cook, S. P., Coombs, D., Cooper, S. R., Corre, Y., Corrigan, G., Cortes, S., Coster, D., Counsell, G. F., Courtois, X., Cox, M., Craciunescu, T., Cramp, S., Crisanti, F., Croft, O., Crombe, K., Crowley, B. J., Cruz, N., Cupido, L., Curuia, M., Cusack, R. A., Czarnecka, A., Dalley, S., Daly, E. T., Dalziel, A., Darrow, D., David, O., Davies, N., Davis, J. J., Day, I. E., Day, C., De Angelis, R., Dearcas, G., de Baar, M. R., Delacal, E., de la Luna, E., de Pablos, J. L., De Temmerman, G., DE TOMMASI, Gianmaria, de Vries, P. C., Degli Agostini, F., Delabie, E., del Castillo Negrete, D., Delpech, L., Denisov, G., Denyer, A. J., Denyer, R. F., Devaux, S., Devynck, P., Di Matteo, L., Dipace, L., Dirken, P. J., Dnestrovskiy, A., Dodt, D., Dominiczak, K., Dorling, S. E., Douai, D., Down, A. P., Doyle, P. T., Drake, J. R., Dreischuh, T., Drozdov, V., Dumortier, P., Dunai, D., Duran, I., Durodíe, F., Dylst, K., Eaton, R., Edlington, T., Edwards, A. M., Edwards, D. T., Edwards, P. K., Eich, T. h., Ekedahl, A., Elevant, T., Elfimov, A., Ellingboe, B., Elsmore, C. G., Emmoth, B., Ericsson, G., Eriksson, L. G., Eriksson, A., Esposito, B., Esser, H. G., Estrada, T., Evangelidis, E. A., Evans, G. E., Ewart, G. D., Ewers, D. T., Falchetto, G., Falie, D., Fanthome, J. G. A., Farina, D., Farthing, J. W., Fasoli, A., Faugeras, B., Fedorczak, N., Felton, R. C., Fenzi, C., Fernandes, H., Ferreira, J. A., Ferreira, J., Ferron, J., Fessey, J. A., Figini, L., Figueiredo, A., Figueiredo, J., Finburg, P., Finken, K. H., Fischer, U., Fitzgerald, N., Flanagan, J., Fleming, C., Fonseca, A., Forbes, A. D., Ford, O., Formisano, A., Fraboulet, D., Francis, R. J., Frassinetti, L., Fresa, R., Friconneau, J. P., Frigione, D., Fuchs, J. C., Fullard, K., Fundamenski, W., Furno Palumbo, M., Gafert, J., Ǵal, K., Galṽao, R., Garavaglia, S., Garbet, X., Garcia, J., Gar cia Munoz, M., Gardner, W., Garibaldi, P., Garnier, D., Garzotti, L., Gatu Johnson, M., Gaudio, P., Gauthier, E., Gaze, J. W., Gear, D. F., Gedney, J., Gee, S. J., Gelfusa, M., Genangeli, E., Gerasimov, S., Geraud, A., Gerbaud, T., Gherendi, M., Ghirelli, N., Giacalone, J. C., Giacomelli, L., Gibson, C. S., Gil, C., Gilligan, S. J., Gimblett, C. G., Gin, D., Giovannozzi, E., Giroud, C., Giruzzi, G., Glowacz, S., Godwin, J., Goff, J. K., Gohil, P., Goloborod’Ko, V., Gonçalves, B., Goniche, M., Gonzales, S., Gonźalezde Vicente, S. M., Goodyear, A., Gorelenkov, N., Gorini, G., Goulding, R., Graham, B., Graham, D., Graham, M. E., Granucci, G., Graves, J., Green, N. R., Greuner, H., Grigore, E., Griph, F. S., Grisolia, C., Gros, G., Grossetti, G., Groth, M., Gr̈unhagen, S., Gryaznevich, M. P., Guirlet, R., Gulejova, B., Gunn, J., Gupta, A., Guzdar, P., Hacek, P., Hackett, L. J., Hacquin, S., Haist, B., Hakola, A., Hall, S. J., Hallworthcook, S. P., Hamilton, D. T., Han, H., Handley, R. C., Harding, S., Harling, J. D. W., Harting, D., Harvey, M. J., Haupt, T. D. V., Havlickova, E., Hawkes, N. C., Hawryluk, R., Hay, J. H., Hayashi, N., Haydon, P. W., Hayward, I. R., Hazel, S., Heesterman, P. J. L., Heidbrink, W., Heikkinen, J., Hellesen, C., Hellsten, T., Hemming, O. N., Hender, T. C., Henderson, M., Hennig, C., Hennion, V., Hidalgo, C., Higashijima, S., Hill, J. W., Hill, M., Hill, K., Hillairet, J., Hillis, D., Hirai, T., Hitchin, M., Hobirk, J., Hogan, C., Hogben, C. H. A., Hogeweij, G. M. D., Hollingham, I. C., Holyaka, R., Homfray, D. A., Honeyands, G., Hong, S. H., Hopf, C., Horn, B. A., Horton, A. R., Horton, L. D., Hotchin, S. P., Hough, M. R., Houlberg, W., Howell, D. F., Hron, M., Huber, A., Huddleston, T. M., Hudson, Z., Hughes, M., Ḧuhnerbein, M., Hume, C. C., Hunt, A. J., Hunter, C. L., Hutchinson, T. S., Huygen, S., Huysmans, G., Hyn̈onen, V., Ide, S., Igreja, R., Illescas, C., Imbeaux, F., Ivanova, D., Ivings, E., Jachmich, S., Jackson, G., Jacquet, P., Jakubowska, K., Jakubowski, M., James, P. V., Jaspers, R. J. E., Jednorog, S., Jenkins, I., Jennison, M. A. C., Jeskins, C., Jin Kwon, O., Joffrin, E., Johnson, M. F., Johnson, R., Johnson, T., Jolovic, D., Jonauskas, V., Jones, E. M., Jones, G., Jones, H. D., Jones, T. T. C., Jouvet, M., Juṕen, C., Kachtchouk, I., Kaczmarczyk, J., Kallenbach, A., K̈allne, J., Kalupin, D., Ḱalvin, S., Kamelander, G., Kamendje, R., Kappatou, A., Karttunen, S., Kasparek, W., Katramados, I., Kaufmann, M., Kaveney, G., Kaye, A. S., Kear, M. J., Keeling, D. L., Kelliher, D., Kempenaars, M., Khilar, P., Kidd, N. G., Kiisk, M., Kim, K. M., King, R. F., Kinna, D. J., Kiptily, V., Kirnev, G., Kirneva, N., Kirov, K., Kirschner, A., Kisielius, R., Kislov, D., Kiss, G., Kiviniemi, T., Kizane, G., Klein, A., Klix, A., Knaup, M., Kneuper, K., Kneupner, H., Knight, P. J., Knipe, S. J., Kocan, M., K̈ochl, F., Kocsis, G., Konz, C., Koppitz, T., Korotkov, A., Koslowski, H. R., Kotov, V., Kovari, M. D., Kovarik, K., Kramer, G., Krasilnikov, A., Krasilnikov, V., Kraus, S., Kreter, A., Krieger, K., Kritz, A., Krivchenkov, Y., Kruezi, U., Krychowiak, M., Krylov, S., Ksiazek, I., Kubic, M., Kuhn, S., K̈uhnlein, W., Kurki Suonio, T., Kurowski, A., Kuteev, B., Kuyanov, A., La Haye, R., Laan, M., Labate, C., Lachichi, A., Lam, N., Lang, P., Large, M. T., Lassiwe, I., Last, J. R., Lawson, K. D., Laxåback, M., Layne, R. A., Lazzaro, E., Leguern, F., Leblanc, B., Leggate, H. J., Lehnen, M., Leigheb, M., Lengar, I., Lennholm, M., Lerche, E., Lescure, C. N., Li, Y., Li Puma, A., Liang, Y., Likonen, J., Lin, Y., Linke, J., Linstead, S. A., Lipshultz, B., Litaudon, X., Litvak, A. G., Liu, Y., Loarer, T., Loarte, A., Lobel, R. C., Lomas, P. J., Long, F. D., L̈onnroth, J., Looker, D. J., Lopez, J., Lotte, P. h., Loughlin, M. J., Loving, A. B., Lowry, C., Luce, T., Lucock, R. M. A., Lukanitsa, A., Lungu, A. M., Lungu, C. P., Lyssoivan, A., Macheta, P., Mackenzie, A. S., Macrae, M., Maddaluno, G., Maddison, G. P., Madsen, J., Maget, P., Maggi, C., Maier, H., Mailloux, J., Makowski, M., Manning, C. J., Mansfield, M., Manso, M. E., Mantica, P., Mantsinen, M., Maraschek, M., Marchetto, C., Marchitti, M. A., Mardenfeld, M., Marechal, J. L., Marinelli, M., Marinoni, A., Marinucci, M., M̈arki, J., Marocco, D., Marren, C. A., Martin, D., Martin, D. L., Martin, G., Martin, Y., Mart́ın Soĺıs, J. R., Masaki, K., Masiello, A., Maslov, M., Maszl, C., Matilal, A., Mattei, M., Matthews, G. F., Maviglia, F., May, C. R., Mayer, M., Mayoral, M. L., Mazon, D., Mazzotta, C., Mazzucato, E., Mccarthy, P., Mcclements, K. G., Mccormick, K., Mccullen, P. A., Mccune, D., Mcdonald, D. C., Mcgregor, R., Mckivitt, J. P., Meakins, A., Medina, F., Meigs, A. G., Menard, M., Meneses, L., Menmuir, S., Merrigan, I. R., Mertens, P. h., Messiaen, A., Meyer, H., Miano, Giovanni, Miele, M., Migliucci, P., Miller, A. G., Mills, S. F., Milnes, J. J., Min Kim, K., Mindham, T., Mirizzi, F., Mirones, E., Mironov, M., Mitteau, R., Mlynar, J., Mollard, P., Monakhov, I., Monier Garbet, P., Mooney, R., Moradi, S., Moreau, D., Moreau, P. h., Moreira, L., Morgan, A., Morgan, P. D., Morlock, C., Moro, A., Morris, A. W., Mort, G. L., Mrozek, C., Mueck, A., M̈uller, H. W., Murakami, M., Murari, A., Mustata, I., Nabais, F., Nardon, E., Nash, G., Naulin, V., Nave, M. F. F., Nazikian, R., Nedzelski, I., Negus, C. R., Neilson, J. D., Neto, A., Neu, R., Neubauer, O., Newbert, G. J., Newman, M., Nicholls, K. J., Nicolai, A., Nicolas, L., Nieckchen, P., Nielsen, P., Nielsen, A. H., Nielsen, S. K., Nielson, G., Nieto, J., Nightingale, M. P. S., Noble, C., Nocente, M., Nora, M., Nordman, H., Norman, M., Noterdaeme, J. M., Nowak, S., Nunes, I., Ognissanto, F., O’Gorman, T., Olariu, S., Oleynikov, A., O’Mullane, M., Ongena, J., Orsitto, F., Oswuigwe, O. I., Ottaviani, M., Oyama, N., Pacella, D., Paget, K., Palazzo, S., Pamela, J., Pamela, S., Panek, R., Pangione, L., Panin, A., Panis, T. h., Pankin, A., Pantea, A., Parail, V., Parisot, T. h., Parkin, A., Parsloe, A., Parsons, B. T., Pasqualotto, R., Pastor, P., Paterson, R., Paul, M. K., Peach, D., Pearce, R. J. H., Pearson, B. J., Pearson, I. J., Pedrick, L. C., Pedrosa, M. A., Pegourie, B., Pereira, R., Perelli Cippo, E., Pereverzev, G., Perevezentsev, A., Perezvonthun, C. h., Pericoli Ridolfini, V., Perona, A., Perrot, Y., Peruzzo, S., Peschanyy, S., Petravich, G., Petrizzi, L., Petrov, V., Petrzilka, V., Philipps, V., Piazza, G., Piccolo, F., Pietropaolo, A., Pillon, M., Pinches, S. D., Pinna, T., Pintsuk, G., Piovesan, P., Pironti, Alfredo, Pisano, F., Pitts, R., Plaum, B., Plyusnin, V., Polasik, M., Poli, F. M., Pomaro, N., Pompilian, O., Poncet, L., Pool, P. J., Popovichev, S., Porcelli, F., Porfiri, M. T., Portafaix, C., Pospieszczyk, A., Possnert, G., Prestopino, G., Prior, P., Prokopowicz, R., Proverbio, I., Pugno, R., Puiatti, M. E., Purahoo, K., Pustovitov, V., P̈utterich, T. h., P̈uttmann Kneupner, D., Quercia, Antonio, Rachlew, E., Rademaker, R., Rafiq, T., Rainford, M. S. J., Ramogida, G., Rantam̈aki, K., Rapp, J., Rasmussen, J. J., Ratt́a, G., Ravera, G., Reich, M., Reichle, R., Reiser, D., Reiss, R., Reiter, D., Rendell, D., Reux, C., Rewoldt, G., Ribeiro, T. T., Riccardo, V., Richards, D., Rigollet, F., Rimini, F. G., Rios, L., Riva, M., Roberts, J. E. C., Robins, R. J., Robinson, D. S., Robinson, S. A., Robson, D. 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A., Simmons, P. A., Simonetto, A., Simpson, D., Sipila, S., Sips, A. C. C., Sirinelli, A., Sj̈ostrand, H., Skopintsev, D., K. S. l. a. b. k. o. w. s. k. a., Smith, P. G., Snipes, J., Snoj, L., Snyder, S., Soare, S., Solano, E. R., Soldatov, S., Soleto, A., Solomon, W., Soltane, C., Sonato, P., Sopplesa, A., Sorrentino, A., Sousa, J., Sowden, C. B. C., Sozzi, C., Sp̈ah, P., Spelzini, T., Spence, J., Spineanu, F., Spuig, P., Sẗabler, A., Stagg, R. D., Stamp, M. F., Stancalie, V., Stangeby, P., Stan Sion, C., Starkey, D. E., Stead, M. J., Stephen, A. V., Stevens, A. L., Stober, J., Stokes, R. B., Stork, D., Stoyanov, D., Strachan, J., Strand, P., Stransky, M., Strauss, D., Strintzi, D., Studholme, W., Suna, Y., Subba, F., Summers, H. P., Sun, Y., Surdu Bob, C., Surrey, E., Sutton, D. J., Svensson, J., Swain, D., Syme, B. D., Symonds, I. D., Szepesi, T., Szydlowski, A., Tabares, F., Takalo, V., Takenaga, H., Tala, T., Talbot, A. 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D., Zatz, I., Zefran, B., Zeidner, W., Zerbini, M., Zhang, T., Zhu, Y., Zilli, E., Zimmermann, O., Zoita, V., Zoletnik, S., Zwingman, W., JET EFDA Contributors, Romanelli, F, Laxaback, M, Abel, I, Afanesyev, V, Agarici, G, Aggarwal, K, Airila, M, Akers, R, Alarcon, T, Albanese, R, Alexeev, A, Alfier, A, Allan, P, Almaviva, S, Alonso, A, Alonso, M, Alper, B, Altmann, H, Alves, D, Ambrosino, G, Amosov, V, Anda, G, Andersson, F, Andersson Sunden, E, Andreev, V, Andrew, Y, Angelone, M, Anghel, M, Anghel, A, Angioni, C, Apruzzese, G, Arcis, N, Arena, P, Argouarch, A, Ariola, M, Armitano, A, Armstrong, R, Arnoux, G, Arshad, S, Artaserse, G, Artaud, J, Ash, A, Asp, E, Asunta, O, Atanasiu, C, Atkins, G, Axton, M, Ayres, C, Baciero, A, Bailescu, V, Baiocchi, B, Baker, R, Balboa, I, Balorin, C, Balshaw, N, Banks, J, Baranov, Y, Barbier, D, Barlow, I, Barnard, M, Barnsley, R, Barrena, L, Barrera, L, Baruzzo, M, Basiuk, V, Bateman, G, Batiston, P, Baumgarten, N, Baylor, L, Bazylev, B, Beaumont, P, Beausang, K, Becoulet, M, Bekris, N, Beldishevski, M, Bell, A, Belli, F, Bellinger, M, Bellizio, T, Belo, P, Belonohy, E, Bennett, P, Benterman, N, Berger By, G, Bergsaker, H, Berk, H, Bernardo, J, Bertrand, B, Beurskens, M, Bieg, B, Bienkowska, B, Biewer, T, Bigi, M, Bilato, R, Bird, J, Bizarro, J, Blackman, T, Blanchard, P, Blanco, E, Blum, J, Bobkov, V, Boboc, A, Boilson, D, Bolshakova, I, Bolzonella, T, Boncagni, L, Bonheure, G, Bonnin, X, Borba, D, Borthwick, A, Botrugno, A, Boulbe, C, Bouquey, F, Bourdelle, C, Bovert, K, Bowden, M, Boyce, T, Boyer, H, Bozhenkov, A, Brade, R, Bradshaw, J, Braet, J, Braic, V, Braithwaite, G, Brault, C, Braune, H, Breizman, B, Bremond, S, Brennan, P, Brett, A, Breue, J, Brezinsek, S, Bright, M, Briscoe, F, Brix, M, Brombin, M, Brown, B, Brown, D, Bruschi, A, Brzozowski, J, Bucalossi, J, Buckley, M, Budd, T, Budny, R, Bunting, P, Buratti, P, Burcea, G, Butcher, P, Buttery, R, Cacao, R, Calabro, G, Callaghan, C, Caminade, J, Camp, P, Campling, D, Canik, J, Cannas, B, Capel, A, Carannante, G, Card, P, Cardinali, A, Carlstrom, T, Carman, P, Carralero, D, Carraro, L, Carter, T, Carvalho, B, Carvalho, P, Casati, A, Castaldo, C, Caughman, J, Cavazzana, R, Cavinato, M, Cecconello, M, Cecil, F, Cenedese, A, Centioli, C, Cesario, R, Challis, C, Chandler, M, Chang, C, Chankin, A, Chapman, I, Child, D, Chiru, P, Chitarin, G, Chugonov, I, Ciric, D, Clairet, F, Clarke, R, Clay, R, Clever, M, Coad, J, Coates, P, Coccorese, V, Cocilovo, V, Coda, S, Coelho, R, Coenen, J, Coffey, I, Colas, L, Cole, M, Collins, S, Combs, S, Compan, J, Conboy, J, Conroy, S, Cook, N, Cook, S, Coombs, D, Cooper, S, Corre, Y, Corrigan, G, Cortes, S, Coster, D, Counsell, G, Courtois, X, Cox, M, Craciunescu, T, Cramp, S, Crisanti, F, Croft, O, Crombe, K, Crowley, B, Cruz, N, Cupido, L, Curuia, M, Cusack, R, Czarnecka, A, Dalley, S, Daly, E, Dalziel, A, Darrow, D, David, O, Davies, N, Davis, J, Day, I, Day, C, De Angelis, R, de Arcas, G, de Baar, M, de la Cal, E, de 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Subjects
Nuclear and High Energy Physics, 52.55.Fa Tokamaks, spherical tokamak, Materials science, Tokamak, Physics and Astronomy (all), Condensed Matter Physics, Física [Ciências exactas e naturais], Cyclotron, law.invention, Bootstrap current, Physical sciences [Natural sciences], law, Physics::Plasma Physics, ITER, divertor, FIS/03 - FISICA DELLA MATERIA, Nuclear and High Energy Physic, Jet (fluid), Safety factor, Divertor, 52.50.Qt Plasma heating by radio-frequency field, Settore FIS/01 - Fisica Sperimentale, magnetic confinement, Magnetic confinement fusion, Física, 52.55.Rk Power exhaust, JET, overview, Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin), Computational physics, Physical sciences, ICR, ICP, helicons, ___, JET, Beta (plasma physics), Atomic physics, tokamaks
Abstract

Since the last IAEA conference, the scientific programme of JET has focused on the qualification of the integrated operating scenarios for ITER and on physics issues essential for the consolidation of design choices and the efficient exploitation of ITER. Particular attention has been given to the characterization of the edge plasma, pedestal energy and edge localized modes (ELMs), and their impact on plasma facing components (PFCs). Various ELM mitigation techniques have been assessed for all ITER operating scenarios using active methods such as resonant magnetic field perturbation, rapid variation of the radial field and pellet pacing. In particular, the amplitude and frequency of type I ELMs have been actively controlled over a wide parameter range (q(95) = 3-4.8, beta(N)

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