1. The inhibiting effect of catecholamine-melanins on UV-induced lecithin peroxidation
- Author
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M. Porębska-Budny, K. Stępień, T. Wilczok, and A.M. Hollek
- Subjects
Indoles ,food.ingredient ,Antioxidant ,Epinephrine ,Ultraviolet Rays ,Thiobarbituric acid ,Dopamine ,medicine.medical_treatment ,Biophysics ,Synthetic membrane ,Lecithin ,Melanin ,Lipid peroxidation ,Norepinephrine ,chemistry.chemical_compound ,Catecholamines ,food ,Phosphatidylcholine ,medicine ,Radiology, Nuclear Medicine and imaging ,Melanins ,Liposome ,Radiation ,integumentary system ,Radiological and Ultrasound Technology ,Electron Spin Resonance Spectroscopy ,Dihydroxyphenylalanine ,Kinetics ,chemistry ,Biochemistry ,Phosphatidylcholines ,Lipid Peroxidation ,sense organs - Abstract
It was found that the yield of thiobarbituric acid reactive substances in UV-irradiated liposome membranes was significantly suppressed in the presence of catecholamine-melanins, indicating their ability to inhibit lipid peroxidation. The extent of inhibition depended on the type and concentration of melanin polymers. Melanin-copper complexes inhibited lecithin photooxidation less effectively than copper-free melanins derived from the same precursor. The antioxidant efficiency of melanins appears to be related to the levels of intrinsic and photo-induced free radical centers in the melanin polymer, as well as to accessibility of these centers for active species formed during irradiation of liposomes.
- Published
- 1992
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