85 results on '"M. Panzeri"'
Search Results
2. The current role of renal tumour biopsy in the management of patients with suspected renal cancer: a prospective observational study
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C.A. Bravi, G. Rosiello, G. Baiamonte, I. Rowe, A. Nini, D. Canibus, F. Trevisani, G. Colandrea, R. Bertini, G. Brembilla, M. Panzeri, F. De Cobelli, A. Salonia, F. Montorsi, and U. Capitanio
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Diseases of the genitourinary system. Urology ,RC870-923 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Published
- 2020
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3. Neuroatypical 'Moving Mirrors': exploring the impact of camera movements on individuals with Autism Spectrum Disorders without intellectual disabilities.
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B. Demartini, V. Nistico’, R. Del Giudice, F. Serio, G. Boido, G. Ingrosso, F. Lombardi, C. Sanguineti, V. Casula, A. Baccara, E. Chiudinelli, F. Vairano, F. M. Panzeri, M. Giori, P. M. Inghilleri di Villadauro, R. Faggioli, O. Gambini, and T. Subini
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Psychiatry ,RC435-571 - Abstract
Introduction Neurofilmology is a young and evolving research field, at the intersection between neuroscience and movie experiences, that explores how the brain processes and responds to visual storytelling. It involves examining the cognitive and emotional effects of movies on viewers, including social cognition and perspective-taking aspects. However, up to date, these studies have focused only on the neurotypical population, hence constituting a considerable gap in the literature with respect to individuals with neuroatypical functioning. Objectives Aim of this study was to investigate the experience of film viewing and its correlates in individuals with a diagnosis of Autism Spectrum Disorders (ASD). Methods 30 neurotypical individuals and 30 individuals with ASD without intellectual disabilities were asked to observe 12 short video clips of 3 seconds length, showing an agent grasping an object from a table, and filmed with three different camera techniques: Still, Steadycam, Zoom; for each clip, they were asked to respond to six question on a Visual Analogue Scale (0-100) designed to investigate participants’ potential feeling of involvement with the observed scene, their comfort with the different filming conditions, and their estimation of the ecological plausibility of the different types of camera movements. Results Participants felt more involved watching videos filmed with a Steadycam, with respect to the Zoom and Still condition. Within the neurotypical group participants felt more comfortable when the camera was in motion (both Steadycam and Zoom condition) compared to the Still condition; no differences were found between conditions in the ASD group, as if they felt equally comfortable in every condition administered, regardless the filming technique. Conclusions First, our results reinforce prior findings regarding the influence of different camera techniques on neurotypical individuals. Second, they add to the existing literature suggesting that individuals with ASD may exhibit differences in their subjective experiences related to empathizing with characters and immersing themselves as actors when the camera replicates naturalistic movements, resulting in a diminished overall fulfillment in the movie-watching process. Disclosure of Interest None Declared
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- 2024
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4. System integration based on packing, piping and harness routing automation using graph-based design languages
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J. Dinkelacker, D. Kaiser, M. Panzeri, P. Parmentier, M. Neumaier, C. Tonhäuser, and S. Rudolph
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Aerospace Engineering ,Transportation - Abstract
The implementation of a fully instrumented, automated and simulation-enabled engineering software platform capable of automating the currently still manual model-based systems engineering (MBSE) design process for physical systems architecture generation and optimization in an aircraft wing is presented. The software platform uses graph-based design languages to integrate and entirely automate the mainly manual packing, piping and harness routing design. This design automation and optimization is achieved by a novel software stack of an optimization software coupled with a design compiler. It is shown that through rule-based model generation by a design compiler in the form of a design graph as a central data model, a cross-domain data consistency is achieved. This allows for automated execution and coupling of engineering tasks over several different domains such as packing, piping and routing design to converge to an optimized wing physical architecture design variant in agreement with given predetermined design constraints.
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- 2023
5. Linguistic validation of the Sex Fantasy Questionnaire into the Italian language
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C. Tortora and M. Panzeri
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Sexual fantasies ,Erotic thoughts ,Linguistic validation ,Obstetrics and Gynecology ,Psychology (miscellaneous) ,Sexual thoughts ,Erotic imagery - Published
- 2022
6. Description of the first Cretaceous (Santonian) articulated skeletal lungfish remains from South America, Argentina
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Karen M. PANZERI, Soledad GOUIRIC CAVALLI, Alberto L. CIONE, and Leonardo S. FILIPPI
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new species ,Ceratodontoidei ,Sarcopterygii ,Argentina ,new genus ,Paleontology ,Dipnoi ,Ceratodontidae ,Cretaceous ,Santonian ,Neuquén Bassin - Abstract
The fossil record of dipnoans is mostly represented by tooth plates and jaw bones, whereas nearly complete or complete skulls are rare. Here, we describe a new dipnoan from the Santonian (Upper Cretaceous) of Patagonia (Argentina) using three-dimensional renderings generated by CT scans. It consists of a near-complete skull and postcranial material. Rinconodus salvadori n. gen., n. sp. is diagnosed by a combination of features, such as medial series composed of two unpaired bones, mediolateral series composed of two paired bones, lateral series with at least one bone, medial edge of tooth plates longer than the lingual edge and equally curved, upper tooth plates contiguous or close to one another with five denticulations, lower tooth plates widely separated with four denticulations, first denticulation of upper tooth plates longer and thinner than the remaining denticulations, and posteriorly curved, first denticulation of lower tooth plates relatively straight and longer than the remaining ones, among other characters. The new species is based on the first two nearly complete Santonian dipnoan skulls from South America. Moreover, the materials presented here are the geologically youngest dipnoan remains consisting of a near-complete skull and postcranium from the Cretaceous of Gondwana.
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- 2022
7. The South American dipnoan Metaceratodus baibianorum (Dipnoi, Ceratodontidae) from the Upper Cretaceous La Colonia Formation, Patagonia, Argentina: an approach from the histology of the tooth plates
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Karen M. Panzeri, María E. Pereyra, and Alberto L. Cione
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Paleontology - Published
- 2022
8. Sublethal effects of carbendazim in Jenynsia multidentata detected by a battery of molecular, biochemical and genetic biomarkers
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Juan Cruz Carrizo, Mirta Lujan Menone, Ana M. Panzeri, M. Valeria Amé, and Jesica Y. Götte
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Gills ,Health, Toxicology and Mutagenesis ,0211 other engineering and technologies ,GENOTOXICITY ,Zoology ,Fresh Water ,02 engineering and technology ,010501 environmental sciences ,Biology ,Detoxification enzymes ,01 natural sciences ,Antioxidants ,Ciencias de la Tierra y relacionadas con el Medio Ambiente ,purl.org/becyt/ford/1 [https] ,DETOXIFICATION ENZYMES ,chemistry.chemical_compound ,purl.org/becyt/ford/1.5 [https] ,Cyprinodontiformes ,FISH ,IMMUNE RESPONSE ,Cytochrome P-450 CYP1A1 ,FUNGICIDES ,Animals ,ATP Binding Cassette Transporter, Subfamily B, Member 1 ,OXIDATIVE STRESS ,Ecosystem ,Micronuclei, Chromosome-Defective ,0105 earth and related environmental sciences ,021110 strategic, defence & security studies ,Carbendazim ,Jenynsia multidentata ,Public Health, Environmental and Occupational Health ,General Medicine ,Pollution ,Oxidative Stress ,chemistry ,Liver ,Ciencias Medioambientales ,%22">Fish ,Cytokines ,Benzimidazoles ,Carbamates ,Biomarkers ,Water Pollutants, Chemical ,CIENCIAS NATURALES Y EXACTAS - Abstract
The fungicide carbendazim (CBM) has been applied all around the world but its potential adverse effects other than its recognized activity as endocrine disruptor in non target organisms have been scarcely studied. The aims of this work were (1) to use a battery of biomarkers that can reflect potential negative effects such as oxidative stress, genotoxicity, neurotoxicity or altered immune response; and (2) to examine biomarkers of detoxification by analyzing the gene expression of cytochrome P4501A1 (CYP1A1) and the multi-xenobiotic resistance protein P-glycoprotein (P-gp) in the freshwater fish Jenynsia multidentata exposed to environmentally relevant concentrations of CBM during 24 h. Fish exposed to 5 μg/L showed inhibition of GST activity and an increase of TBARs contents in gills, the organ of direct contact with waterborne contaminants. Genotoxicity – measured in peripheral blood-was evidenced by the increases of micronuclei frequency when fish were exposed to 5, 10 and 100 μg/L CBM and of nuclear abnormalities (NA) frequency at 0.05, 0.5, 5, 10 and 100 μg/L CBM. The expression inhibition of interleukin (IL-1β) and tumor necrosis factor a (TNF-α) at 10, and 5 and 10 μg/L CBM, respectively, indicated an altered immune response. The expression of CYP1A1 was down regulated in liver at 10 μg/L and of P-gp at 5 μg/L CBM, indicating a possible slow on CBM metabolization. On the other hand, in gills CYP1A1 decreased at 5 and 10 μg/L while P-gp was induced at 5 and 100 μg/L CBM. Overall, most of these significant effects were detected below 10 μg/L CBM, in a range of realistic concentrations in aquatic ecosystems worldwide. Fil: Götte, Jesica Y.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; Argentina Fil: Carrizo, Juan Cruz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina Fil: Panzeri, Ana María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; Argentina Fil: Amé, María Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina Fil: Menone, Mirta Lujan. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; Argentina
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- 2020
9. Imidacloprid Causes DNA Damage in Fish: Clastogenesis as a Mechanism of Genotoxicity
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Mirta Lujan Menone, Ana M. Panzeri, Sandra Karina Medici, Maria Fernanda Simoniello, and Fernando Gastón Iturburu
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0301 basic medicine ,Insecticides ,DNA damage ,Health, Toxicology and Mutagenesis ,DNA fragmentation ,Fresh Water ,010501 environmental sciences ,Toxicology ,medicine.disease_cause ,01 natural sciences ,Ciencias Biológicas ,Neonicotinoids ,03 medical and health sciences ,chemistry.chemical_compound ,Imidacloprid ,medicine ,Neonicotinoid ,Animals ,Carcinogen ,0105 earth and related environmental sciences ,Micronucleus Tests ,Fishes ,Cichlids ,General Medicine ,Ecología ,Nitro Compounds ,Pollution ,Molecular biology ,Comet assay ,030104 developmental biology ,Micronucleus ,chemistry ,Comet Assay ,CIENCIAS NATURALES Y EXACTAS ,Genotoxicity ,DNA Damage - Abstract
Neonicotinoids are one of the most widely used insecticides in the world. DNA damage is considered an early biological effect which could lead to reproductive and carcinogenic effects. The present study aimed to evaluate DNA damage and bases oxidation as a mechanism of genotoxicity, on the freshwater fish Australoheros facetus acutely exposed to imidacloprid (IMI). The Comet assay with the nuclease ENDO III enzyme was performed for detecting pyrimidine bases oxidation using blood samples. Micronucleus and other nuclear abnormalities frequencies were also quantified. A significant increase of damage index at 100 and 1000 µg/L IMI was detected; while ENDO III score increased from 1 to 1000 µg/L IMI; varying both in a linear concentration-response manner. MN frequency increased in fish exposed to 1000 µg/L IMI. These results show that short-term exposures to environmentally relevant concentrations of IMI could affect the genetic integrity of fishes through oxidative damage. Fil: Iturburu, Fernando Gastón. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; Argentina Fil: Simoniello, Maria Fernanda. Universidad Nacional del Litoral; Argentina Fil: Medici, Sandra Karina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; Argentina Fil: Panzeri, Ana M.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; Argentina Fil: Menone, Mirta Lujan. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; Argentina
- Published
- 2018
10. Metaceratodus baibianorum, a new dipnoan species from the Upper Cretaceous of southern South America supported by traditional and geometric morphometric analyses
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Alberto Luis Cione, Nahuel Antu Muñoz, Karen M. Panzeri, and Soledad Gouiric Cavalli
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0106 biological sciences ,010506 paleontology ,Metaceratodus ,biology ,Paleontology ,biology.organism_classification ,010603 evolutionary biology ,01 natural sciences ,Cretaceous ,stomatognathic diseases ,stomatognathic system ,Geology ,0105 earth and related environmental sciences - Abstract
The Upper Cretaceous record of lungfishes from South America is abundant but represented mainly by tooth plates and associated jaw bones. A new dipnoan species from the Upper Cretaceous of the La C...
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- 2020
11. Epithelioid hemangioma of the arm: a rare benign vascular lesion
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M, Cellina, primary, CMA, Martinenghi, additional, M, Panzeri, additional, and G, Oliva, additional
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- 2018
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12. Oxidative stress and genotoxicity in the South American cichlid, Australoheros facetus, after short-term sublethal exposure to endosulfan
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Mirta Lujan Menone, Karina S.B. Miglioranza, Ana M. Panzeri, Andrea Carina Crupkin, Pedro Carriquiriborde, Julieta Renee Mendieta, and M. L. Ballesteros
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Thiobarbituric acid ,Health, Toxicology and Mutagenesis ,BIOMARKERS ,Otras Ciencias de la Tierra y relacionadas con el Medio Ambiente ,Glutathione reductase ,medicine.disease_cause ,Ciencias de la Tierra y relacionadas con el Medio Ambiente ,Superoxide dismutase ,chemistry.chemical_compound ,LIPID PEROXIDE ,ANTIOXIDANT ENZYMES ,TBARS ,medicine ,HYDROGEN PEROXIDE ,MICRONUCLEI ,biology ,Lipid peroxide ,Chemistry ,General Medicine ,Molecular biology ,Biochemistry ,Catalase ,ENDOSULFAN ,Micronucleus test ,biology.protein ,Agronomy and Crop Science ,CIENCIAS NATURALES Y EXACTAS ,Genotoxicity - Abstract
Short-term responses at the antioxidant enzymatic systems, together with genotoxic effects were studied in the freshwater fish Australoheros facetus, exposed to endosulfan (ES) (0.02, 0.5, 5, 10 lg/L) for 24 h. Brain was the most responsive organ, showing inhibition of the enzymatic systems together with an increase of hydrogen peroxide (H2O2) content. Concentration-dependent inhibition was observed for superoxide dismutase (SOD), catalase (CAT) and glutathione reductase (GR) with IC25 values of 0.012, 0.017, 0.018 lg/L, respectively. In liver, a similar behavior was observed for SOD with IC25 values of 2.22 lg/L. In addition, increased thiobarbituric acid reactive substances (TBARs) at 5 lg/L and H2O2 at 5 and 10 lg/L were observed. No effects were evidenced on ethoxyresorufin O-deethylase (EROD), glutathione-S-transferase (GST), GR and CAT activities. In gills, only H2O2 decreased at 0.5 and 5 lg/L ES. Genotoxic effects were detected by the increase of the frequency of both, nuclear abnormalities (NA) at 0.02 lg/L and micronucleus (MN) at 5 lg/L. Environmentally realistic concentrations of ES exerted toxic responses in A. facetus, encouraging the further field validation of the observed pattern (tissue specificity, sensitiveness and concentration-response relationship) as a potential suit of biomarkers for assessing acute sublethal effects in A. facetus under short-term pulsed exposure to ES. Fil: Crupkin, Andrea Carina. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Departamento de Ciencias Marinas. Laboratorio de Ecotoxicología; Argentina Fil: Carriquiriborde, Pedro. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Química. Centro de Investigaciones del Medio Ambiente; Argentina Fil: Mendieta, Julieta Renee. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; Argentina Fil: Panzeri, Ana M.. Universidad Nacional de Mar del Plata. Facultad de Cs.exactas y Naturales. Departamento de Biologia. Laboratorio de Genetica; Argentina Fil: Ballesteros, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mar del Plata. Instituto de Investigaciones Marinas y Costeras; Argentina. Universidad Nacional de Mar del Plata; Argentina. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Diversidad y Ecologia Animal; Argentina Fil: Miglioranza, Karina Silvia Beatriz. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Departamento de Ciencias Marinas. Laboratorio de Ecotoxicología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mar del Plata. Instituto de Investigaciones Marinas y Costeras; Argentina Fil: Menone, Mirta Lujan. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mar del Plata. Instituto de Investigaciones Marinas y Costeras; Argentina. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Departamento de Ciencias Marinas. Laboratorio de Ecotoxicología; Argentina
- Published
- 2013
13. Uptake, distribution in different tissues, and genotoxicity of imidacloprid in the freshwater fish Australoheros facetus
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Fernando Gastón Iturburu, Valeska Contardo-Jara, Andrea Carina Crupkin, Markus Zömisch, Stephan Pflugmacher, Mirta Lujan Menone, and Ana M. Panzeri
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0301 basic medicine ,Gill ,Gills ,Health, Toxicology and Mutagenesis ,Fresh Water ,010501 environmental sciences ,medicine.disease_cause ,01 natural sciences ,Ciencias de la Tierra y relacionadas con el Medio Ambiente ,Toxicology ,CONTAMINANT OF EMERGING CONCERN ,03 medical and health sciences ,chemistry.chemical_compound ,Neonicotinoids ,FISH ,Imidacloprid ,parasitic diseases ,medicine ,Environmental Chemistry ,Bioassay ,Animals ,Tissue Distribution ,Food science ,0105 earth and related environmental sciences ,MICRONUCLEUS ASSAY ,biology ,Dose-Response Relationship, Drug ,Neonicotinoid ,Imidazoles ,BIOACCUMULATION ,Cichlids ,biology.organism_classification ,Nitro Compounds ,030104 developmental biology ,chemistry ,Organ Specificity ,Bioaccumulation ,Toxicity ,Freshwater fish ,FRESHWATER TOXICOLOGY ,Meteorología y Ciencias Atmosféricas ,Genotoxicity ,CIENCIAS NATURALES Y EXACTAS ,Water Pollutants, Chemical ,DNA Damage ,Mutagens - Abstract
The neonicotinoid imidacloprid is under re-evaluation by regulatory agencies because of the poor current information available regarding its potential effects. One of the goals of the present study was to determine imidacloprid uptake and distribution in the freshwater fish Australoheros facetus experimentally exposed for 24 h and 48 h to 100 μg/L, 300 μg/L, and 2500 μg/L. The toxicity of imidacloprid to fish reported in the literature is in the milligrams per liter or gram per liter range, but sublethal effects at micrograms per liter in some groups other than fish have been described. Another goal of the present study was to evaluate imidacloprid's potential genotoxicity and to compare it between the individual compound and a commercial formulation. Concentrations of imidacloprid were measured in water, brain, muscle, gills, gut, liver, and blood by liquid chromatography-tandem mass spectrometry. Imidacloprid was detected in all the tissues tested. Concentrations were higher after 48 h than after 24 h in liver, gills, gut, and muscle, whereas in brain and blood they were similar at both exposure times. Although there was no accumulation, only uptake, of imidacloprid, genotoxicity was observed. In fish exposed to IMIDA NOVA 35®, increased micronucleus frequency at 100 µg/L and 1000 µg/L was detected, whereas in the imidacloprid active ingredient bioassay it increased only at 1000 µg/L imidacloprid. The present findings warn of the possible consequences that fish living in freshwater ecosystems can suffer. Environ Toxicol Chem 2017;36:699–708. © 2016 SETAC. Fil: Iturburu, Fernando Gastón. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; Argentina Fil: Zömisch, Markus. Technishe Universitat Berlin; Alemania Fil: Panzeri, Ana María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; Argentina Fil: Crupkin, Andrea Carina. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Departamento de Ciencias Marinas. Laboratorio de Ecotoxicología; Argentina Fil: Contardo Jara, Valeska. Technishe Universitat Berlin; Alemania Fil: Pflugmacher, Stephan. Technishe Universitat Berlin; Alemania Fil: Menone, Mirta Lujan. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; Argentina
- Published
- 2016
14. Modelling shoreline evolution to enhance flood risk assessment
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M. Panzeri and S. Stripling
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Shore ,Hydrology ,geography ,geography.geographical_feature_category ,Flood myth ,business.industry ,Environmental resource management ,Flooding (psychology) ,Ocean Engineering ,Coastal erosion ,Flood risk assessment ,Information system ,Coastal engineering ,business ,Beach morphodynamics - Abstract
Traditional flood-risk assessment considers coastal defences to be static features with foreshores represented simply with an assigned elevation and slope. However, beach elevations can vary rapidly over time, perhaps fluctuating seasonally, and often losing or gaining volume over a longer time period. Their dynamic nature ultimately influences the risk of coastal erosion and flooding. In a regional flood-risk assessment, in which beaches offer protection to a variety of backshore features such as seawalls, soft cliffs, and dunes, the ability to represent the beach dynamics fronting these defences is important. At regional scale, it is also necessary to consider the various backshore environments that may be encountered over a long stretch of coastline, and how their individual processes affect flood risk, particularly if they are erodible. An integrated framework of dynamically linked numerical models of coastal processes and statistical analysis methods is being developed to enhance regional flood-risk assessment via consideration of coastal evolution and foreshore morphodynamics. The framework is run entirely from within commercially available geographical information system software where model operation and numerical output is managed; standard geographical information system analysis and database capabilities are therefore also available within the modelling system. This paper outlines the basis of the modular framework, and demonstrates how flood-risk assessment is enhanced.
- Published
- 2009
15. A flood system risk analysis model with dynamic sub-element 2D inundation model, dynamic breach growth and life-loss
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B Gouldby, J Lhomme, C McGahey, M Panzeri, M Hassan, N Burgada, C Orue, C Diaz, S Jamieson, G Wright, M Van Damme, and M Morris
- Published
- 2012
16. Italian validation of INQoL, a quality of life questionnaire for adults with muscle diseases
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Roberto Massa, Mauro Montanari, M. Grandi, Leda Volpi, Corrado Angelini, M. Panzeri, G. Meola, Antonio Toscano, Luisa Politano, Tiziana Mongini, C. Solimene, Liliana Vercelli, G. Apolone, Gabriele Siciliano, S. Gandossini, M. B. Panico, Michael R. Rose, Olimpia Musumeci, Valeria A. Sansone, Arianna Palmieri, Sansone, Va, Panzeri, M, Montanari, M, Apolone, G, Gandossini, S, Rose, Mr, Politano, Luisa, Solimene, C, Siciliano, G, Volpi, L, Angelini, C, Palmieri, A, Toscano, A, Musumeci, O, Mongini, T, Vercelli, L, Massa, R, Panico, Mb, Grandi, M, and Meola, G.
- Subjects
Gerontology ,Male ,Questionnaires ,Adult ,INQoL ,muscle diseases ,quality of life ,SF-36 ,medicine.medical_specialty ,Health Status ,Concurrent validity ,Muscle disorder ,Quality of life ,Muscular Diseases ,Predictive Value of Tests ,Surveys and Questionnaires ,medicine ,Criterion validity ,Humans ,Reliability (statistics) ,Muscle Weakness ,Adult patients ,business.industry ,Mental Disorders ,Age Factors ,Middle Aged ,Health Surveys ,Physical limitations ,Neurology ,Italy ,Physical therapy ,Muscle strength ,Female ,Settore MED/26 - Neurologia ,Neurology (clinical) ,business ,Quality of Life - Abstract
Background and purpose: A quality of life (QoL) questionnaire for neuromuscular diseases was recently constructed and validated in the United Kingdom in a sample of adult patients with a variety of muscle disorders. Preliminary results suggested it could be a more relevant and practical measure of QoL in muscle diseases than generic health measures of QoL. The purpose of our work was: (i) To validate INQoL in Italy on a larger sample of adult patients with muscle diseases (ii) to compare INQoL to SF-36. Methods: We have translated into Italian and applied language adaptations to the original UK INQoL version. We studied 1092 patients with different muscle disorders and performed (i) test–retest reliability (n = 80); (ii) psychometric (n = 345), knowngroup (n = 1092), external criterion (n = 70), and concurrent validity with SF-36 (n = 183). Results: We have translated and formally validated the Italian version of INQoL confirming and extending results obtained in the United Kingdom. In addition to good results in terms of reliability, known-group and criterion validity, a comparison with the SF-36 scales showed a stronger association between INQoL total index and SF-36 physical (r = )0.72) than mental (r = )0.38) summary health indexes. When considering comparable domains of INQoL and SF-36 with respect to an objective measure of muscle strength assessment (MMRC), regression analysis showed a stronger correlation using INQoL rather than SF-36 scores. Conclusions: INQoL is recommended to assess QoL in muscle diseases because of its ability to capture physical limitations that are specifically relevant to the muscle condition.
- Published
- 2010
17. Treatment for periodic paralysis
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Michael R. Rose, Thera P. Links, M. Panzeri, Valeria A. Sansone, and Giovanni Meola
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medicine.medical_specialty ,Weakness ,Neuromuscular disease ,Dichlorphenamide ,Hypokalemic Periodic Paralysis ,GENE SCN4A ,Placebo ,Hypokalemic periodic paralysis ,ACETAZOLAMIDE ,Internal medicine ,ANDERSEN-TAWIL-SYNDROME ,medicine ,Paralysis ,Humans ,Pharmacology (medical) ,Hyperkalemic periodic paralysis ,Carbonic Anhydrase Inhibitors ,Randomized Controlled Trials as Topic ,business.industry ,MUTATIONS ,Pinacidil ,MUSCLE SODIUM-CHANNEL ,Periodic paralysis ,PARAMYOTONIA-CONGENITA ,medicine.disease ,WEAKNESS ,Paramyotonia congenita ,Physical therapy ,medicine.symptom ,business ,MYOTONIA-CONGENITA ,ALPHA-SUBUNIT ,Paralysis, Hyperkalemic Periodic ,BETA-ADRENERGIC TREATMENT - Abstract
Background Primary periodic paralyses are rare inherited muscle diseases characterised by episodes of flaccid weakness affecting one or more limbs, lasting several hours to several days, caused by mutations in skeletal muscle channel genes. Objectives The objective of this review was to systematically review treatment of periodic paralyses. Search strategy We searched the Cochrane Neuromuscular Disease Group Trials Register, MEDLINE (from January 1966 to July 2007), and EMBASE (from January 1980 to July 2007) and any other available international medical library sources from the University of Milan for randomised trials. Selection criteria We included randomised (including cross-over studies) and quasi- randomised trials in participants with primary periodic paralyses, in which any form of treatment, including physical therapy and alternative therapies, was compared to placebo or another treatment. Data collection analysis Our primary outcome measure was the change in attack severity or frequency by eight weeks from the start of treatment. Our secondary outcome measures were: change in muscle strength and mass; change in Quality of Life, using Short Form 36 (SF36) or similar; preference of treatment strategy; adverse effects at eight weeks. Main results Three studies met our inclusion criteria. In one study dichlorphenamide (DCP) vs placebo was tested in two groups of participants: 42 with hypokalemic periodic paralysis (HypoPP) and 31 with hyperkalemic periodic paralysis (HyperPP), based on clinical criteria. Thirty-four of 42 participants with hypokalemic periodic paralysis completed both treatment phases. For the 34 participants having attack rate data for both treatment phases, the mean improvement in attack rate (P = 0.02) and severity-weighted attack rate (P = 0.01) on DCP relative to placebo were statistically significant. Fifteen preferred DCP, three placebo and six their baseline medication. Twenty-four of 31 participants with hyperkalemic periodic paralysis completed both treatment phases: for the 16 participants who had attack rate data for both treatment phases, the mean improvement in attack rate (P = 0.006) and in severity-weighted attack rate (P = 0.02) on DCP relative to placebo were significant. Fifteen preferred DCP, one placebo and five their baseline medication. Acetazolamide proved to improve muscle strength in eight participants with HypoPP in one other study and pinacidil, a potassium channel opener, also improved muscle strength in 2/4 participants with HypoPP in a third study. Authors' conclusions The largest included study that met our inclusion criteria suggested that DCP was effective in the prevention of episodic weakness in both hypokalemic and hyperkalemic periodic paralyses. The other two studies provide some evidence that either acetazolamide or pinacidil may improve muscle strength. However we still lack sufficient evidence to provide full guidelines for the treatment of people with periodic paralysis.
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- 2008
18. Micronuclei induction in Rana catesbeiana tadpoles by the pyrethroid insecticide lambda-cyhalothrin
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Marcela Alejandra Campana, Fernando Noel Dulout, Víctor J. Moreno, and Ana M. Panzeri
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Veterinary medicine ,Rana catesbeiana ,Pyrethroid ,lcsh:QH426-470 ,Ciencias Veterinarias ,genotoxicity ,Genotoxicidad ,Biology ,medicine.disease_cause ,Peripheral blood ,Rana ,Toxicology ,Cyhalothrin ,chemistry.chemical_compound ,lcsh:Genetics ,micronucleus test ,lambda-cyhalothrin ,chemistry ,tadpoles ,Micronucleus test ,Genetics ,medicine ,Pyrethroid insecticide ,Molecular Biology ,Genotoxicity - Abstract
Pyrethroid lambda-cyhalothrin genotoxicity was evaluated using the micronucleus test in Rana catesbeiana tadpoles. The effects of concentration and exposure time on the micronuclei frequency were studied in blood smears obtained from tadpoles exposed to four concentrations (0.02, 0.1, 0.2 and 0.4 μg/L) of the compound for 24, 48, 72 and 96 h and 8, 15, 20 and 30 days. As a positive control, tadpoles were exposed to cyclophosphamide (5 mg/L). The micronucleated cell frequency was expressed per 1,000 cells. R. catesbeiana tadpoles exposed to increasing concentrations of lambda-cyhalothrin showed an increase in the micronuclei frequency in peripheral blood. Tadpoles exposed to cyclophosphamide (CP) also showed a significant increase in micronucleated erythrocytes which peaked after 15 days. These results suggest that R. catesbeiana tadpoles may provide a useful model for monitoring water pollution., Facultad de Ciencias Veterinarias
- Published
- 2003
19. Micronucleus test in fish from a pampasic pond (Argentina): an estimation of the presence of genotoxic compounds
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M A, Campana, A M, Panzeri, A H, Escalante, V J, Moreno, and F N, Dulout
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Erythrocytes ,Micronucleus Tests ,Mutagenicity Tests ,Water Supply ,Fishes ,Animals ,Water Pollutants, Chemical ,DNA Damage ,Environmental Monitoring ,Xenobiotics - Abstract
The Los Padres pond is one of the commonly shallow, polymictic lakes from the so-called depressed Pampa (Argentina). Its watershed includes one affluent, named Los Padres creek, which flows through horticultural lands wherein great amounts of pesticides are applied. Opposite to this stream, the pond drains into La Tapera creek that is the effluent running toward the sea. Many studies have confirmed the capacity of various pesticides to induce genetic damage. The use of micronucleus (MN) tests in fish has enabled us to detect the presence of contaminants in the lakewater and to evaluate theirgenotoxic effects. For this purpose, water samples were collected during April, August, and December 1999 from both creeks characterized by different environmental conditions. In the laboratory, specimens oftetras Cheirodon interruptus (Pisces, Characidae) were reared in water samples from the two creeks. Control fish were kept in drinking water. Fifteen individuals from each experimental group were sacrificed after 24-, 48-, and 72-hour exposure intervals. Micronucleus frequency in fish erythrocytes was determined, and the Kruskal-Wallis test for statistic analysis was used. We made the following observations: (1) Highly significant differences occurred in MN frequency between the control group and the samples from both creeks. (2) An increase in MN frequency was evident in specimens sampled from the affluent input during the month of December. These results allowed us to conclude that the increase in MN frequency observed in fish belonging to both sampling sites would indicate the existence of genotoxic compounds in the Los Padres pond. The high MN frequency in fish collected near Los Padres creek inlet might be related to the polluted load transported by the affluent and discharged into the lake's surface waters. Future work would allow us to develop efficient methods for predicting the presence of genotoxic contaminants. It would be possible then to propose strategies for regulating and decreasing the sources of pollution that affect human health.
- Published
- 2002
20. Long-term follow-up free of ventricular fibrillation recurrence after resuscitated cardiac arrest in a myotonic dystrophy type 1 patient
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M. Panzeri, Francesco Sardanelli, Guido De Ambroggi, A. Zanolini, Riccardo Cappato, Luigi De Ambroggi, Valeria A. Sansone, and Giovanni Meola
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Male ,musculoskeletal diseases ,congenital, hereditary, and neonatal diseases and abnormalities ,medicine.medical_specialty ,Adolescent ,Long term follow up ,Resuscitation ,Population ,Myotonic dystrophy ,Sudden cardiac death ,Recurrence ,Physiology (medical) ,Internal medicine ,Humans ,Myotonic Dystrophy ,Medicine ,education ,education.field_of_study ,business.industry ,Incidence (epidemiology) ,medicine.disease ,Heart Arrest ,Treatment Outcome ,Ventricular Fibrillation ,Ventricular fibrillation ,cardiovascular system ,Cardiology ,Cardiology and Cardiovascular Medicine ,business ,Resuscitated Cardiac Arrest ,Follow-Up Studies - Abstract
Cardiac involvement in myotonic dystrophy type 1 (DM1) is frequent with increased incidence of conduction disturbances and sudden cardiac death when compared with general population. We describe a 38-year-old man in whom the diagnosis of DM1 was made 8 years after occurrence of cardiac arrest owing to ventricular fibrillation and discuss management of DM1 patients at risk for sudden cardiac death.
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- 2009
21. T01-O-13 The Brief Index of Sexual Functioning for Women (BISF-W): validation on an Italian sample
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M. Panzeri, M. Dona, L. Ronconi, and G. Optale
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Obstetrics and Gynecology ,Psychology (miscellaneous) - Published
- 2008
22. T01-P-07 The Brief Index of Sexual Functioning for Men (BISF-M): validation on an Italian sample
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V. Raoli and M. Panzeri
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Cronbach's alpha ,Sexual functioning ,Internal consistency ,Obstetrics and Gynecology ,Human sexuality ,Psychology (miscellaneous) ,Factorial analysis ,Sexual function ,Factor structure ,Psychology ,Male sexual function ,Developmental psychology - Abstract
Objective The purpose of this research was to develop a brief self-report index of male sexual functioning, which could be comparable in form and in content to the Brief Index of Sexual Functioning for Women (BISF-W, Taylor et al. 1994). The study also presented an evaluation of the psychometric properties of the resulting measure, the Brief Index of Sexual Functioning for Men (BISF-M). Method The sample was made up of 190 Italian men. It was compared with a sample of 1332 Italian women (Panzeri et al.2004). An Exploratory Factorial Analysis (EFA) was performed with the method of principal components and OBLIMIN rotation. Internal consistency was calculated by means of Cronbach alpha coefficients for each factor. MANCOVAs were calculated to compare men's and women's scores. Results EFA on men's data yielded 4 factors: Sexuality of the couple (F1); Self-eroticism (F2); Satisfaction/Dissatisfaction (F3); Anal sexuality (F4), confirming the same factor structure of BISF-W, even if with some item-level gender variations. Internal consistency was also demonstrated. Cronbach alpha results (.94 for F1; .89 for F2; .75 for F3; .83 for F4) attested a good degree of homogeneity among the items. MANCOVAs revealed that men had higher scores than women on many sexual function dimensions, such as sexual fantasies, desires and self-eroticism. Conclusions This research provided a validation of the BISF-M as an instrument for evaluating male sexual function. The study pointed out a globally similar factor structure for men and women and confirmed gender differences in sexual interests, attitudes and behaviour, already described in prior literature.
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- 2008
23. T01-O-14 Factor structure of the Italian Sexual Inhibition/Excitation (SIS/SES) scales
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M. Baldetti, G. Altoe, E. Janssen, M. Panzeri, Davide Dèttore, and F. Zanella
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education.field_of_study ,Sexual inhibition ,Population ,Obstetrics and Gynecology ,Factor structure ,Structural equation modeling ,Confirmatory factor analysis ,Goodness of fit ,Sample size determination ,Statistics ,Psychology (miscellaneous) ,education ,Psychology ,Statistic - Abstract
Objective This study involves the initial validation of the Sexual Inhibition & Sexual Excitation Scales (SIS/SES) in Italy. A total of 947 men (mean age = 24.74 years, SD = 5.29) and 1083 women (mean age = 22.49 years, SD = 4.08) participated in the study. The sample was recruited in three different regions: 43% of the sample lived in Padova, 27.3% in Firenze and 29.5% in Lecce. Method To examine the factor structure of the SIS/SES a second-order confirmatory factor analysis was performed, excluding the SIS1_2 subscale, which had to be excluded from the analysis to improve the goodness of fit of the model. Assessment of fit was based on several indices. Since the chi-square statistic is dependent on sample size and not uncommonly significant, we considered two relative fit indices, the NNFI (Non-Normed Fit Index) and the CFI (Comparative Fit Index), which are appropriate for use with both small and large samples. The Root Mean Square Error of Approximation (RMSEA) was also used. This is an absolute fit index assessing approximation of parameter estimates to true parameters in the population. Results Most indices (NNFI = .94; CFI = .95; RMSEA = .053) pointed to an acceptable fit of the observed data, having NNFI and CFI above .90, and RMSEA below .08 (Bentler, 1990; Browne, 1990). Conclusions These results support the hierarchical factor structure, involving one excitation and two inhibition factors, of the Italian SIS/SES.
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- 2008
24. Evaluation of hematological parameters, oxidative stress and DNA damage in the cichlid Australoheros facetus exposed to the fungicide azoxystrobin
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Andrea C. Crupkin, Ariana B. Fulvi, Fernando G. Iturburu, Sandra Medici, Julieta Mendieta, Ana M. Panzeri, and Mirta L. Menone
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Fungicide ,Comet assay ,Freshwater fish ,Oxidative stress ,Environmental pollution ,TD172-193.5 ,Environmental sciences ,GE1-350 - Abstract
Azoxystrobin (AZX) is a broad-spectrum systemic fungicide massively used worldwide. Its mode of action consists in the inhibition of mitochondrial respiration decreasing the synthesis of ATP and leading to oxidative stress in the target fungus. However, whether this effect occurs in non target organisms has been scarcely studied. The objectives of this work were (1) to evaluate biomarkers of oxidative stress, hematological, physiological and of genotoxicity in the native cichlid fish Australoheros facetus exposed to environmentally relevant concentrations of AZX and (2) to compare these biomarkers in different developmental stages using juvenile and adult fish (n = 6) exposed during 48 h. The exposure concentrations were 0 (negative control, C (−)), 0.05, 0.5, 5 and 50 μg/L AZX of the commercial formulation AMISTAR®. Blood was drawn to evaluate hematology, and DNA damage through the comet assay (CA) and micronucleus test (MN). Genotoxicity was observed by mean of both biomarkers in juvenile and adult fish at 50 μg/L AZX. Samples of liver and gills were used to determine antioxidant enzymes activity, hydrogen peroxide (H2O2) and malondialdehyde (MDA) contents. In juvenile fish inhibition of superoxide dismutase (SOD) was observed in liver at 0.05, 5 and 50 μg/L AZX and in gills at 5 and 50 μg/L AZX. Glutathione- S- transferases (GST) activity increased in gills at all AZX concentrations tested. In adult fish, increase of hepatic catalase (CAT) activity at 0.5 and 50 μg/L AZX and MDA content at 50 μg/L AZX were observed. In gills only H2O2 content showed changes at 50 μg/L AZX. The sensitivity showed by gills constitutes the first report about AZX toxicity in this organ. All these negative effects were observed in the range of realistic AZX concentrations, which warns of the possible consequences that it may have on the health of aquatic biota. Differences between juvenile and adult fish demonstrate the relevance of considering the developmental stage on the evaluation of biomarkers.
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- 2021
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25. A multicenter study of the risk of major bleeding in patients with and without cirrhosis undergoing percutaneous liver procedures.
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Blasi A, Garcia-Criado A, Moreno-Rojas J, Perez-Serrano C, Ubre M, Dieguez I, Panzeri M, Caballero M, Rivera L, Radosevic A, Puig G, Martinez L, Ruiz S, Blaso A, Bell P, Castillo A, Ponce RJ, Escobosa P, Rivas E, and Cardenas A
- Abstract
Percutaneous liver procedures are frequently performed in patients with abnormal coagulation tests. Current guidelines suggest prophylactic transfusion is not mandatory in all patients with liver disease or cirrhosis, depending on the risk of bleeding. This study aims to describe the incidence and risk of major bleeding after percutaneous liver procedure in patients with and without cirrhosis. This retrospective study includes patients who underwent percutaneous liver biopsy and radiofrequency and microwave ablation of liver lesions at 3 centers in Spain. A transfusion protocol was considered for platelet counts <50,000 and/or international normalized ratio >1.5. The primary outcome was major bleeding. A total of 1797 patients were included in the study, with 316 having cirrhosis (18%) and 1481 without cirrhosis (82%). Among the patients with cirrhosis, 80 were classified as Child A, and percutaneous liver biopsy was the most frequent procedure (86%). Fourteen patients (0.8%) experienced major bleeding, with 0.4% occurring in radiofrequency and microwave ablation and 0.8% in percutaneous liver biopsy. Bleeding occurred in 0.6% of patients with cirrhosis compared to 0.8% in those without ( p = ns). No clinical or procedural variables were associated with bleeding. Twenty-five patients (1.4%) had an international normalized ratio >1.5, and 22 patients (1.2%) had a platelet count <50,000. Only 24% (6/25) of patients with an international normalized ratio >1.5 were transfused with fresh frozen plasma, and 72% (16/22) of those with platelet counts <50,000 received platelet transfusion. Patients with cirrhosis were more frequently transfused (5.9% vs. 1.5%). None of the patients who met the criteria for transfusion experienced major bleeding, regardless of whether they received a transfusion, and none of the patients who had a major bleeding episode met the transfusion criteria. In this cohort, major bleeding after percutaneous liver procedure occurred in <1% of patients, making it a low-risk procedure for patients with and without cirrhosis. Although not uniformly adopted, the current transfusion protocol still led to unnecessary blood product administration., (Copyright © 2024 American Association for the Study of Liver Diseases.)
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- 2024
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26. Communication of the diagnosis to Klinefelter subjects: an observational study on a key moment of the patient's life.
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Garolla A, Kiesswetter M, Angelini S, Cavalieri F, Foresta C, Panzeri M, and Ferlin A
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- Humans, Male, Adult, Adolescent, Middle Aged, Young Adult, Female, Parents psychology, Physician-Patient Relations, Surveys and Questionnaires, Klinefelter Syndrome diagnosis, Klinefelter Syndrome psychology, Communication
- Abstract
Purpose: Klinefelter syndrome (KS) is the most prevalent sex chromosome disorder among males. The communication of the KS diagnosis holds significant implications for the diagnosis's acceptance. Recently, the increased use of prenatal diagnostic procedures has raised the question of whether, when, and by whom information, once provided to parents, should be communicated to their children/adolescents. Currently, there is limited information on this topic. This study aims to investigate the most suitable timing, content, and healthcare professionals (HCPs) according to KS patients' suggestions for conveying the diagnosis, analyzing the impact of communicating the KS diagnosis on patients and their reception of the communication in real-life situations. Furthermore, research entails a comparison of the actual communication and the patients' preferred mode of communication., Methods: Self-reported interview data was collected from 196 adults diagnosed with KS. The interview was structured, consisting of 32 multiple-choice questions covering various areas related to diagnosis communication., Results: Most patients with Klinefelter syndrome reported that earlier communication would have been beneficial. Communication before the age of 18 and by parents increased the likelihood of overcoming negative consequences and relying on psychological support., Conclusion: To mitigate the adverse effects of poorly timed and inadequately delivered communication, typically by a single person, it is advisable that such communication be carried out at the onset of adolescence by an interdisciplinary team of HCPs (including psychologists, geneticists, endocrinologists) and parents. The information provided should not solely concentrate on hormonal and fertility aspects, but also consider other factors such as psychological variables., (© 2024. The Author(s).)
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- 2024
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27. Assessment of the psychometric properties of the italian version of the midwifery student evaluation of practice (MIDSTEP-IT): A validity and reliability study.
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Nespoli A, Sacco GGA, Bouhachem FZ, Motta F, Paredi S, Antolini L, Panzeri M, Pellegrini E, and Fumagalli S
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- Humans, Italy, Reproducibility of Results, Surveys and Questionnaires, Female, Adult, Education, Nursing, Baccalaureate methods, Education, Nursing, Baccalaureate standards, Translating, Clinical Competence standards, Clinical Competence statistics & numerical data, Educational Measurement methods, Educational Measurement standards, Translations, Students, Nursing psychology, Students, Nursing statistics & numerical data, Psychometrics methods, Psychometrics instrumentation, Midwifery education, Midwifery standards
- Abstract
Background: Clinical learning is a crucial component of the midwifery education program, necessary to support the acquisition of professional abilities through the integration of theoretical and practical learning experiences. Evaluating Bachelor of Midwifery students' perception of their clinical learning experiences is important to improve midwifery educational programs., Aim: the objective of this study was the translation, cultural adaptation, and validation of the Midwifery Student Evaluation of Practice (MidSTEP) in a group of Italian midwives' students., Methods: "Translation and Cultural Adaptation of Patient Reported Outcomes Measures - Principles of Good Practice" guidelines were adopted to achieve the MidSTEP Italian version. Exploratory Factor Analysis was performed. Internal consistency for reliability was assessed using Cronbach's alpha reliability coefficient (α) and Omega coefficient (ω), while Intraclass Correlation Coefficients (ICC) were used to determine if the tool was stable over time., Findings: The Italian version of MidSTEP (MidSTEP-IT) has good internal consistency: considering the Clinical Learning Environment Scale, Cronbach's α was 0.839 (for the "Skill Development" subscale α was equal to 0.739 and for the "Philosophy of Midwifery Practice" subscale α was equal to 0.825) while considering the Midwifery Preceptor Scale, Cronbach's α was 0.920. Factor analysis does not fully reflect the factorial analysis of the original version., Conclusion: The MidSTEP-IT had been proven to be a valid and reliable tool, easy and fast to administer, that could be effectively helpful for investigating and measuring the Italian midwifery students' perception of their clinical learning experiences, according to the setting and impact of mentors on their professional growth. It is an innovative tool, valuable in both clinical practice and research to highlight the importance of encouraging a supportive clinical learning environment and an efficient preceptorship., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
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- 2024
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28. Intrapartum Quality of Care among Healthy Women: A Population-Based Cohort Study in an Italian Region.
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Fumagalli S, Nespoli A, Panzeri M, Pellegrini E, Ercolanoni M, Vrabie PS, Leoni O, and Locatelli A
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- Humans, Italy, Female, Pregnancy, Adult, Cohort Studies, Midwifery statistics & numerical data, Young Adult, Delivery, Obstetric statistics & numerical data, Parturition, Quality of Health Care
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Although the quality of care during childbirth is a maternity service's goal, less is known about the impact of the birth setting dimension on provision of care, defined as evidence-based intrapartum midwifery practices. This study's aim was to investigate the impact of hospital birth volume (≥1000 vs. <1000 births/year) on intrapartum midwifery care and perinatal outcomes. We conducted a population-based cohort study on healthy pregnant women who gave birth between 2018 and 2022 in Lombardy, Italy. A total of 145,224 (41.14%) women were selected from nationally linked databases. To achieve the primary aim, log-binomial regression models were constructed. More than 70% of healthy pregnant women gave birth in hospitals (≥1000 births/year) where there was lower use of nonpharmacological coping strategies, higher likelihood of epidural analgesia, episiotomy, birth companion's presence at birth, skin-to-skin contact, and first breastfeeding within 1 h ( p -value < 0.001). Midwives attended almost all the births regardless of birth volume (98.80%), while gynecologists and pediatricians were more frequently present in smaller hospitals. There were no significant differences in perinatal outcomes. Our findings highlighted the impact of the birth setting dimension on the provision of care to healthy pregnant women.
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- 2024
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29. Physiological stress response to urbanisation differs between native and invasive squirrel species.
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Santicchia F, Tranquillo C, Wauters LA, Palme R, Panzeri M, Preatoni D, Bisi F, and Martinoli A
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- Animals, Male, Humans, Sciuridae physiology, Hypothalamo-Hypophyseal System, Pituitary-Adrenal System, Stress, Physiological, Introduced Species, Urbanization
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Novel pressures derived from urbanisation can alter native habitats and ultimately impact wildlife. Coping with such human-driven changes might induce shifts in species phenotypic traits, such as physiological responses to anthropogenic stressors. Preadaptation to face those challenges has been suggested to favour settlement and spread of invasive alien species in urbanised areas which, consequently, might respond differently than ecologically similar native species to stressors posed by urbanisation. The activation of the hypothalamic-pituitary-adrenal (HPA) axis and the subsequent release of glucocorticoids (GCs) has been suggested to mediate responses to anthropogenic disturbance in vertebrates. Furthermore, intraspecific competition, in conjunction with stressors related to urbanisation, might affect invasive and native species physiological stress responses differently. Using a parallel pseudo-experimental study system we measured faecal glucocorticoid metabolite (FGM) concentrations of the native Eurasian red squirrel and the invasive alien Eastern grey squirrel along a rural-urban gradient and in relation to conspecific density. The two species responded differently to challenges posed by the synergic effect of urbanisation and intraspecific competition. Association of FGMs and conspecific density in native red squirrels varied between rural and suburban sites, potentially depending on differential HPA axis responses. In urban sites, this relationship did not differ significantly from that in rural and suburban ones. Conversely, invasive grey squirrels' FGMs did not vary in relation to conspecific density, nor differed along the rural-urban gradient. Improving knowledge about native and competing invasive species' physiological responses to anthropogenic stressors can support conservation strategies in habitats altered by man. Our findings suggested that the invasive squirrels might be preadapted to cope with these challenges in urbanised areas, potentially increasing their success under the future global change scenario., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
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- 2024
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30. Midwives' stress and burnout during the Omicron wave in Italy: An observational survey.
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Fumagalli S, Panzeri M, Borrelli S, Ornaghi S, Antolini L, Sacco GGA, Formenti M, Sala S, and Nespoli A
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Aim: To evaluate midwives' level of stress and burnout during the COVID-19 Omicron phase in Italy. Secondary aims were to explore the impact of the pandemic on midwives' personal dimensions and professional activities and potential supporting strategies., Design: A mixed-methods study was undertaken from July to December 2022., Methods: Data were collected using a national online observational survey. Descriptive and inferential analyses were performed to evaluate stress, burnout and the impact of the pandemic on personal and professional dimensions. A deductive qualitative approach was used to analyse open-ended responses, that were merged with quantitative data following a convergent mixed-methods approach., Results: A total of 1944 midwives participated in the survey. The stress summary score mean was 10.34, and 562 midwives (28.91%) experienced burnout. The intention to reduce working hours was reported by 202 midwives (10.39%), with 60.40% (n = 122) of them experiencing burnout. The intention to leave clinical practice within the following 2 years was reported by 239 (12.29%), with 68.20% (n = 163) of them experiencing burnout. All the personal dimensions and professional activities considered were defined by more than half of midwives as being impacted 'Moderately' or 'To a great extent' by pandemic. Stress and burnout frequencies increased when the midwives' perception of the pandemic effects was higher. Potential supporting strategies described by midwives as the most important in increasing their ability to cope with the pandemic were 'Women's awareness of the midwives' role' (n = 1072; 55.14%) and 'Family and friends' emotional support' (n = 746; 38.38%)., Conclusion: Our findings suggested strategies to support a positive and safe working environment for midwives during a pandemic emergency, with potential transferability to similar contexts when human resources are lacking. It is recommended that maternity services provide the necessary resources for a safe and supportive working environment to prevent high stress levels and chronic burnout., Impact: Studies conducted during the first COVID-19 pandemic wave showed an increased level of stress, anxiety, burnout, post-traumatic stress disorder and depression experienced by healthcare professionals; moreover, midwives experienced drastic changes in care pathways and policies with struggles identified when providing high-quality woman-centred care following pandemic restrictions. Although it is recommended, there is lack of knowledge about long-term psychological effects of COVID-19 for midwives. Our study highlights that during the Omicron wave midwives experienced a high level of stress and burnout with an impact on individual dimensions and professional activities. Their stress and burnout were influenced by several factors, including restrictions in place, lack of organizational acknowledgement, work overload and need for extra childcare cover. Maternity services should provide the necessary resources for a safe and supportive working environment to prevent high stress levels and chronic burnout. Recommendations on how to facilitate this are suggested., Reporting Method: During the writing process, we referred to 'The Strengthening the Reporting of Observational Studies Epidemiology Statement', the guidelines for reporting observational studies from the Equator network., Patient or Public Contribution: No patient or public contribution. WHAT DOES THIS PAPER CONTRIBUTE TO THE WIDER GLOBAL CLINICAL COMMUNITY?: Work overload conditions negatively impacted on the quality of maternity services. Improving organizational aspects, reducing working hours, promoting family and friends' emotional support and improving women's awareness of midwife's role were the main strategies reported by midwives. These suggestions for ensuring a positive and safe working environment for midwives during a pandemic emergency could potentially be applied to similar situations where human resources are lacking., (© 2024 John Wiley & Sons Ltd.)
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- 2024
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31. Development of the Italian version of the Orgasmic Perception Questionnaire (OPQ).
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Panzeri M, Mauro D, Ronconi L, and Arcos-Romero AI
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- Adult, Humans, Male, Female, Psychometrics, Surveys and Questionnaires, Italy, Orgasm physiology, Perception
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Orgasm is a phase of the human sexual response, and the possible discrepancies between male and female ways to experience it are still not clear in the literature. There is a lack of tools to adequately assess orgasm perception. This study aims to develop an instrument and verify possible differences between males and females. We constructed the Orgasmic Perception Questionnaire (OPQ) through different stages: first, 316 items selection was conducted on a sample of 96 people, where items came mainly from written descriptions of orgasm perception; second, an exploratory factor analysis was conducted on 674 Italian adults with a 63-item OPQ; finally, a confirmatory factor analysis was conducted on 1100 Italian adults with a 47-item OPQ. In the first study, 63 items fitted an equidistributional pattern and were to form the 63-item OPQ used for EFA. The EFA showed that five factors out of 47 explained 44.01% of the total variance and were named: Ecstasy, Contractions, Relaxation, Power, and Sensations. The confirmatory factor analyses run on the 47-item OPQ confirmed that the five-factor structure fits. Moreover, females scored higher than males with an adequate effect size in two factors: Contractions and Sensations. In conclusion, the OPQ could be a useful tool in both clinical settings and research studies to investigate the perception of orgasmic experience in its totality., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2023 Panzeri et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
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- 2023
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32. The sexuality of couples formed during the pandemic: An exploratory study.
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Filisetti S, Tortora C, Paruta C, Piazza FI, and Panzeri M
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- Female, Humans, Male, Sexual Behavior psychology, Sexual Partners psychology, Sexuality psychology, COVID-19 epidemiology, Pandemics
- Abstract
Covid-19 has been affecting people's lives on a social, economic, emotional, and sexual level. This study aims to investigate any change in how couples formed during the pandemic got to know the partner and experienced sexuality, including factors that could have influenced those changes in comparison with a pre-pandemic period. Particularly, focus groups (N = 26 women) were conducted and an online questionnaire (N = 120; 41 men and 79 women) was administered. Given the exploratory qualitative nature of the present research, no specific hypothesis was tested. Most of the sample reported an increase in sexual desire, sexual frequency, and quality of intercourse, perceiving an early development of intimacy. The results highlight the lack of stress and fear of contagion. The intense state of euphoria, typical of the initial phase of the relationship, has perhaps allowed the couples to overcome the obstacles due to the restrictions. This study underlines the role of being in love in the survival of the species, as it allows for the creation of steady relationships even in moments of danger., Competing Interests: The authors have declared that no competing interests exist.
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- 2022
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33. Ultrasound is better than injection pressure monitoring detecting the low-volume intraneural injection.
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Goffin P, Mejia J, Prats-Galino A, Morales L, Panzeri M, and Sala-Blanch X
- Abstract
Introduction: Inadvertent intraneural injection is not infrequent during peripheral nerve blocks. For this reason, injection pressure monitoring has been suggested as a safeguard method that warns the clinician of a potentially hazardous needle tip location. However, doubts remain whether it is superior to the sonographic nerve swelling in terms of earlier detection of the intraneural injection., Methods: An observational cadaveric study was designed to assess injection pressures during an ultrasound-guided intraneural injection of the median nerve. We hypothesized that the evidence of nerve swelling occurred prior to an elevated injection pressure (>15 pound per square inch) measured with a portable in-line monitor. 33 ultrasound-guided intraneural injections of 11 median nerves from unembalmed human cadavers were performed at proximal, mid and distal forearm. 1 mL of a mixture of local anesthetic and methylene blue was injected intraneurally at a rate of 10 mL/min. Following injections, specimens were dissected to assess spread location. Video recordings of the procedures including ultrasound images were blindly analyzed to evaluate nerve swelling and injection pressures., Results: 31 injections were considered for analysis (two were excluded due to uncertainty regarding needle tip position). >15 pound per square inch was reached in six injections (19%) following a median injected volume of 0.6 mL. Nerve swelling was evident in all 31 injections (100%) with a median injected volume of 0.4 mL. On dissection, spread location was confirmed intraneural in all injections., Discussion: Ultrasound is a more sensitive and earlier indicator of the low-volume intraneural injection than injection pressure monitoring., Competing Interests: Competing interests: None declared., (© American Society of Regional Anesthesia & Pain Medicine 2022. No commercial re-use. See rights and permissions. Published by BMJ.)
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- 2022
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34. COVID-19 and Guillain-Barré syndrome: A single-center prospective case series with a 1-year follow-up.
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Ahmad L, Businaro P, Regalbuto S, Gastaldi M, Zardini E, Panzeri M, Vegezzi E, Fiamingo G, Colombo E, and Ravaglia S
- Subjects
- Follow-Up Studies, Humans, RNA, Viral, Retrospective Studies, SARS-CoV-2, COVID-19 complications, COVID-19 epidemiology, Guillain-Barre Syndrome diagnosis
- Abstract
Single reports of Guillain-Barré syndrome (GBS) have been reported worldwide during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. While case reports are likely to be biased toward uncommon clinical presentations, systematic assessment of prospective series can highlight the true clinical features and spectrum. In this prospective, observational study, we included all consecutive patients who developed GBS. In patients with SARS-CoV-2 infection as antecedent, the time-gap between the infection and GBS onset had to be ≤30 days. The referral was a neurological University Research Hospital, in the Italian Region more severely involved by the pandemic, and hospitalizing both COVID+ and non-COVID neurological diseases. Clinical, laboratory, cerebrospinal fluid, and electromyographic features of GBS diagnosed between March 2020 and March 2021 were compared to a retrospective series of GBS diagnosed between February 2019 and February 2020 (control population). Nasopharyngeal swab was still positive at GBS onset in 50% of patients. Mild-to-moderate COVID-related pneumonia, as assessed by X-ray (6 patients) or X-ray plus computerized tomography (2 patients) co-occurred in 6 of 10 patients. GBS diagnosed during the pandemic period, including 10 COVID-GBS and 10 non-COVID-GBS, had higher disability on admission (P = .032) compared to the GBS diagnosed between February 2019 and 2020, possibly related to later hospital referral in the pandemic context. Compared to non-COVID-GBS (n = 10) prospectively diagnosed in the same period (March 2020-2021), post-COVID-GBS (n = 10) had a higher disability score on admission (P = .028), lower sum Medical Research Council score (P = .022) and lymphopenia (P = .025), while there were no differences in GBS subtype/variant, severity of peripheral involvement, prognosis and response to treatment. Cerebrospinal fluid search for SARS-CoV-2 RNA and antiganglioside antibodies were negative in all COVID+ patients. Temporal clustering of cases, coinciding with the waves of the pandemic, and concomitant reduction of the incidence of COVID-negative GBSs may indicate a role for SARS-CoV-2 infection in the development of GBS, although the association may simply be related to a bystander effect of systemic inflammation; lack of prevalence of specific GBS subtypes in post-COVID-GBS also support this view. GBS features and prognosis are not substantially different compared to non-COVID-GBS., Competing Interests: The authors have no conflicts of interest to disclose., (Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.)
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- 2022
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35. Temporal Bone Pneumatization: Relationship With Sex and Variants of the Ethmoid and Sphenoid Bone.
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Gibelli D, Cellina M, Gibelli S, Panzeri M, Termine G, Floridi C, and Sforza C
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- Female, Humans, Male, Petrous Bone diagnostic imaging, Sphenoid Sinus diagnostic imaging, Temporal Bone diagnostic imaging, Ethmoid Bone, Sphenoid Bone diagnostic imaging
- Abstract
Abstract: Pneumatization variants of the temporal bone have a crucial importance in several surgical interventions. However, very few data are known about possible correlation with other pneumatization variants.Pneumatization of glenoid fossa, petrous apex, and infralabyrinthine portion of temporal bone was assessed in 200 computed tomography scans, equally divided between males and females (18-92 years). Pneumatization variants of the ethmoid (concha bullosa, agger nasi, pneumatized crista galli) and the sphenoid sinuses (pneumatized pterygoid processes, anterior clinoid processes, dorsum sellae, volume) were recorded as well.Differences in prevalence of each pneumatization type according to sex and side, among different portions of the temporal bone, and between temporal bone and the pneumatized variants of the ethmoid bone and sphenoid sinuses, were assessed through chi-square test (P < 0.05). Differences in sphenoid volume among different pneumatization degrees of the temporal bone were assessed through 1-way analysis of covariance test (P < 0.05).Pneumatization of the petrous apex and the infralabyrinthine portion was significantly more frequent in males than in females, whereas pneumatization of the glenoid fossa was more often observed on the right side (P < 0.05). Variants of the temporal bone are all related one with each other in males, whereas in females only the relationship between pneumatized petrous apex and infralabyrinthine portion was found. Moreover, in females the pneumatized petrous apex was related with pneumatized anterior clinoid process, and the pneumatized infralabyrinthine portion was related with the sphenoid sinus volume.Results may be useful for predicting these important variants in planning surgical interventions of the cranial base., Competing Interests: The authors report no conflicts of interest., (Copyright © 2021 by Mutaz B. Habal, MD.)
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- 2021
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36. MRI versus Mammography plus Ultrasound in Women at Intermediate Breast Cancer Risk: Study Design and Protocol of the MRIB Multicenter, Randomized, Controlled Trial.
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Bonelli LA, Calabrese M, Belli P, Corcione S, Losio C, Montemezzi S, Pediconi F, Petrillo A, Zuiani C, Camera L, Carbonaro LA, Cozzi A, De Falco Alfano D, Gristina L, Panzeri M, Poirè I, Schiaffino S, Tosto S, Trecate G, Trimboli RM, Valdora F, Viganò S, and Sardanelli F
- Abstract
In women at high/intermediate lifetime risk of breast cancer (BC-LTR), contrast-enhanced magnetic resonance imaging (MRI) added to mammography ± ultrasound (MX ± US) increases sensitivity but decreases specificity. Screening with MRI alone is an alternative and potentially more cost-effective strategy. Here, we describe the study protocol and the characteristics of enrolled patients for MRIB feasibility, multicenter, randomized, controlled trial, which aims to compare MRI alone versus MX+US in women at intermediate breast cancer risk (aged 40-59, with a 15-30% BC-LTR and/or extremely dense breasts). Two screening rounds per woman were planned in ten centers experienced in MRI screening, the primary endpoint being the rate of cancers detected in the 2 arms after 5 years of follow-up. From July 2013 to November 2015, 1254 women (mean age 47 years) were enrolled: 624 were assigned to MX+US and 630 to MRI. Most of them were aged below 50 (72%) and premenopausal (45%), and 52% used oral contraceptives. Among postmenopausal women, 15% had used hormone replacement therapy. Breast and/or ovarian cancer in mothers and/or sisters were reported by 37% of enrolled women, 79% had extremely dense breasts, and 41% had a 15-30% BC-LTR. The distribution of the major determinants of breast cancer risk profiles (breast density and family history of breast and ovarian cancer) of enrolled women varied across centers.
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- 2021
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37. Validation of the Sexual Inhibition/Sexual Excitation Scales (SIS/SES) in Italy: Assessing Gender and Age Differences of Sexual Functioning.
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Panzeri M, Dadomo H, Ronconi L, and Fontanesi L
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- Female, Humans, Inhibition, Psychological, Italy, Male, Psychometrics, Surveys and Questionnaires, Sexual Behavior, Sexual Dysfunctions, Psychological
- Abstract
The Sexual Inhibition Scales and Sexual Excitation Scales (Janssen et al., 2002a), based on the dual control model by Bancroft and Janssen (2000), are part of a 45-item self-report questionnaire evaluating individual tendencies to sexual inhibition or excitation according to three factors: two inhibition factors, SIS1, threat of performance failure, and SIS2, threat of performance consequences, and one excitation factor, SES. In this paper, we aimed to validate and explore psychometric properties of the SIS/SES in a sample of 2260 Italian men and women aged 18 to 75 years. Confirmatory factor analyses showed that the three-factor structure proposed in the original version of the scales fit with our sample. Moreover, our data confirmed the results of the original validation sample: Women scored higher on the SIS and lower on the SES than men did, but no significant differences appeared in the factor scores by age group, except for a gender × age interaction, where younger women had higher SIS2 scores. The SIS/SES appeared to be an effective, appropriate cross-cultural measurement of human sexuality in Italian samples, also shedding light on sexual arousal differences in women and men in our country. We also discuss clinical and therapeutic aspects., (© 2021. The Author(s).)
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- 2021
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38. Lost and found: Helminths infecting invasive raccoons introduced to Italy.
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Romeo C, Cafiso A, Fesce E, Martínez-Rondán FJ, Panzeri M, Martinoli A, Cappai N, Defilippis G, and Ferrari N
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- Animals, Cestode Infections epidemiology, Cestode Infections parasitology, Cestode Infections veterinary, Female, Helminthiasis, Animal parasitology, Introduced Species, Italy epidemiology, Male, Nematode Infections epidemiology, Nematode Infections parasitology, Nematode Infections veterinary, Prevalence, Trematode Infections epidemiology, Trematode Infections parasitology, Trematode Infections veterinary, Animal Distribution, Cestoda isolation & purification, Helminthiasis, Animal epidemiology, Helminths isolation & purification, Nematoda isolation & purification, Raccoons, Trematoda isolation & purification
- Abstract
North American raccoons (Procyon lotor) have been introduced to several European countries, where they may represent a sanitary threat as hosts of several pathogens such as the zoonotic ascarid Baylisascaris procyonis. We carried out parasitological analysis on raccoons introduced to Italy to verify whether the species had carried along B. procyonis or any other gastro-intestinal helminths that may threaten humans, livestock or native wildlife. We examined 64 raccoons culled in Northern Italy during control activities and 3 roadkills opportunistically sampled from a separate population located in central Italy. Helminths were collected from the gastro-intestinal tract through standard parasitological techniques and identified based on a combination of morphology and molecular methods. Overall, examined raccoons showed a poor parasitic fauna, with almost 30% of individuals free of any helminth infection. The most prevalent species were the nematodes Strongyloides procyonis (26.9%), Aonchotheca putorii (25.4%) and Porrocaecum sp. (19.4%). Plagiorchis sp. trematodes were also common (13.4%), whereas cestodes were scarcely represented. With the exception of S. procyonis introduced from North America, all the other identified taxa have either a Eurasian or a wide Holarctic distribution. Despite not finding any B. procyonis in the examined raccoons, passive surveillance for this parasite should be implemented, especially in Tuscany, since the limited host sample examined in the present survey does not allow to exclude its presence., (Copyright © 2021 Elsevier B.V. All rights reserved.)
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- 2021
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39. Noncontrast MR Lymphography in Secondary Lower Limb Lymphedema.
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Cellina M, Martinenghi C, Panzeri M, Soresina M, Menozzi A, Daniele G, and Oliva G
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- Adult, Humans, Lower Extremity diagnostic imaging, Magnetic Resonance Imaging, Retrospective Studies, Lymphedema diagnostic imaging, Lymphedema etiology, Lymphography
- Abstract
Background: Invasive imaging techniques have been applied for lymphedema (LE) assessment; noncontrast MR lymphography (NCMLR) has potential as an alternative, but its performance is not known in secondary lower limb LE., Purpose: To assess the role of NCMRL for the classification and characterization of secondary lower limb LE., Study Type: Retrospective., Population: Fifty adults with clinically diagnosed secondary LE., Field Strength/sequence: 1.5T, 3D T
2 -weighted turbo spin-echo, 3D T2 -weighted turbo spin-echo short tau inversion recovery., Assessment: Three radiologists assessed the following characteristics on NCMRL: honeycomb pattern, dermal thickening, muscular abnormalities, distal dilated lymphatics, inguinal lymph node number, appearance of iliac lymphatic trunks. An LE grading based on the MR images was assigned. The relationship between imaging findings and clinical staging was evaluated, as well as between dermal backflow at lymphoscintigraphy and MR staging, and between the limb swelling duration and peripheral lymphatics dilatation., Statistical Tests: Pearson's correlation test and Cramer's V coefficient were computed to measure the strength of association. The Mann-Whitney test was used to compare the limb swelling duration between patients with and without dilated distal vessels. Agreement among raters was assessed through Kendall's W coefficient of correlation., Results: Clinical stage and the MR grading were correlated, with Cramer's V coefficient of 1 for reader 1 (P < 0.05), 0.846 for reader 2 (P < 0.05), and 0.912 (P < 0.05) for reader 3; agreement between interraters was very good (W = 0.0.75; P = 0.05). A honeycomb pattern (P < 0.05), dermal thickening (P < 0.001), muscular abnormalities (P < 0.05), iliac lymphatic trunks appearance (P < 0.05), distal dilated vessels (P < 0.05), and lymph nodes number (P < 0.05) were significantly correlated with LE clinical stage. Dermal backflow at lymphoscintigraphy was described in 10 (20%) patients and showed a significant correlation with the MR grading (P < 0.05)., Data Conclusion: These preliminary results suggest that NCMRL may provide information useful for the staging and management of patients affected by secondary lower limb LE. Level of Evidence 4 Technical Efficacy Stage 2 J. MAGN. RESON. IMAGING 2021;53:458-466., (© 2020 International Society for Magnetic Resonance in Medicine.)- Published
- 2021
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40. Regional Patterns of Fluid and Fat Accumulation in Patients with Lower Extremity Lymphedema Using Magnetic Resonance Angiography.
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Cellina M, Panzeri M, Soresina M, Menozzi A, Martinenghi C, and Gibelli D
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- Humans, Lower Extremity, Magnetic Resonance Imaging, Patients, Lymphedema, Magnetic Resonance Angiography
- Published
- 2020
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41. Chest Radiography Features Help to Predict a Favorable Outcome in Patients with Coronavirus Disease 2019.
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Cellina M, Panzeri M, and Oliva G
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- Adult, Betacoronavirus, COVID-19, Humans, Middle Aged, Radiography, SARS-CoV-2, Coronavirus, Coronavirus Infections, Pandemics, Pneumonia, Viral
- Published
- 2020
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42. Changes in Sexuality and Quality of Couple Relationship During the COVID-19 Lockdown.
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Panzeri M, Ferrucci R, Cozza A, and Fontanesi L
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The COVID-19 pandemic is heavily influencing people's general well-being worldwide. Since its outbreak, many studies have explored the population's general psychological well-being, while only a few studies have addressed how the COVID-19 pandemic and the lockdown are affecting sexuality. Sexual health, an important aspect of general well-being, has relevant consequences on people's daily lives. Although it is well known that distress can affect sexuality, and it is possible to speculate that the outbreak's psychological outcomes are affecting the population's sexual life; recent literature does not explore couples' sexuality and their relationship quality during the lockdown. The present preliminary research aimed to understand if the Italian population's sexuality has changed, and if so, how it had changed since the spread of COVID-19, and which variables were influencing couples' relationship quality during the COVID-19 lockdown. A questionnaire reserved especially for cohabiting couples was designed and distributed online from April 11 to May 5, 2020, the 5th and 8th weeks, respectively, after the start of the lockdown. Of the 124 respondents who completed the online survey, 73% were females. Despite the pandemic's psychological consequences, when asked directly, most couples responded that they did not perceive any differences in their sexuality. However, some female participants did report a decrease in pleasure, satisfaction, desire, and arousal. The main reasons behind the changes in sexuality in women, therefore, appear to be worry, lack of privacy, and stress. Even when participants seemed to show high levels of resilience, the negative aspects of lockdown could affect their quality of sexual life. This study needs to be completed using qualitative data from online focus groups that have investigated how sexual life has changed and the main needs of couples. All the same, our results will serve to better address population needs and experiences, and provide ad hoc interventions during this unprecedented time of crisis., (Copyright © 2020 Panzeri, Ferrucci, Cozza and Fontanesi.)
- Published
- 2020
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43. Non-contrast MR Lymphography of lipedema of the lower extremities.
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Cellina M, Gibelli D, Soresina M, Menozzi A, Martinenghi C, Panzeri M, and Oliva G
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- Adipose Tissue pathology, Adult, Diagnosis, Differential, Female, Humans, Lower Extremity pathology, Male, Middle Aged, Lipedema diagnostic imaging, Lower Extremity diagnostic imaging, Lymphography, Magnetic Resonance Imaging
- Abstract
Aim: To assess imaging findings and characteristics of the lymphatic system in patients affected by lipedema and lipolymphedema of the lower extremities on Non-Contrast MR Lymphography (NCMRL)., Materials and Methods: 44 lower extremities in 11 consecutive female patients affected by lipedema, and 11 patients with lipolymphedema were examined by NCMRL. MR imaging was performed on 1.5-T system MR equipment. The examination consisted of one 3D short-tau inversion recovery (STIR) and one heavily T2-weighted 3D-Turbo Spin Echo (TSE) sequence., Results: All patients showed symmetrical enlargement of the lower extremities with increased subcutaneous fat tissue. The fat tissue was homogeneous, without any signs of edema in pure lipedema patients. In all the extremities with lipolymphedema, high signal intensity areas in the epifascial region could be detected on the 3D-TSE sequence (p < .001) with evidence of mild epifascial fluid collections (p < .001). No sign of honeycomb pattern fat appearance was observed. The appearance of the iliac lymphatic trunks was normal in both lipedema and lipolymphedema patients. Dilated peripheral lymphatics were observed in 2 patients affected by lipedema, indicating a subclinical status of lymphedema, and in 10 patients with lipolymphedema (p = .001). Signs of vascular stasis were observed in both groups, without statistically significant difference (p = .665)., Conclusion: NCMRL is a non-invasive imaging technique that is suitable for the evaluation of patients affected by lipedema and lipolymphedema, helping in the differential diagnosis., (Copyright © 2020 Elsevier Inc. All rights reserved.)
- Published
- 2020
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44. Feasibility, Reproducibility, and Clinical Validity of a Quantitative Chest X-Ray Assessment for COVID-19.
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Orsi MA, Oliva G, Toluian T, Valenti Pittino C, Panzeri M, and Cellina M
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- Adult, Aged, Aged, 80 and over, Betacoronavirus, COVID-19, Emergency Service, Hospital, Feasibility Studies, Female, Humans, Lung diagnostic imaging, Male, Middle Aged, Observer Variation, Pandemics, Reproducibility of Results, Retrospective Studies, SARS-CoV-2, Coronavirus Infections diagnostic imaging, Pneumonia, Viral diagnostic imaging, Radiography, Thoracic
- Abstract
Chest X-ray (CXR) is an essential first-line tool in COVID-19 pneumonia diagnosis and management. Our study aimed at assessing 1) CXR manifestations, frequency, and distribution; 2) the feasibility and repeatability of a CXR severity score; and 3) the correlation between the CXR severity score and clinical and laboratory parameters. We reviewed baseline CXRs and clinical data of consecutive patients who presented to our emergency department and resulted positive at SARS-CoV-2 reverse transcriptase-PCR oropharyngeal swab test from March 1, 2020 to April 6, 2020. Lung abnormalities and their distribution were analyzed. A score of CXR severity was assigned by two radiologists, independently, according to the extent of lung involvement, with a maximum score of 8 for CXR. Correlations between the CXR score and the clinical data were assessed. One hundred fifty-five patients were included; 143/155 (92%) were positive at baseline CXR. Ground-glass opacity was the most common finding (141/143, 99%). Involvement was mainly bilateral (96/143, 67%), with peripheral distribution (79/143, 55%). The mean CXR severity score was 3.3 (±2); interobserver agreement was excellent, with a Cohen's K correlation coefficient of 0.901. The CXR score showed a significant positive correlation with C-reactive protein, lactate dehydrogenase, and fever duration, and a negative correlation with oxygen saturation. Chest X-ray findings are in line with those reported by computed tomography studies. The use of a visual CXR score, easy to assess and highly reproducible, can reflect the clinical severity and help the patients' management.
- Published
- 2020
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45. A Dual Route Model for Regulating Emotions: Comparing Models, Techniques and Biological Mechanisms.
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Grecucci A, Messina I, Amodeo L, Lapomarda G, Crescentini C, Dadomo H, Panzeri M, Theuninck A, and Frederickson J
- Abstract
The aim of this article is to present recent applications of emotion regulation theory and methods to the field of psychotherapy. The term Emotion Regulation refers to the neurocognitive mechanisms by which we regulate the onset, strength, and the eventual expression of our emotions. Deficits in the regulation of emotions have been linked to most, if not all, psychiatric disorders, with patients presenting either dysregulated emotions, or dysfunctional regulatory strategies. We discuss the implications of regulating emotions from two different theoretical perspectives: the Cognitive Emotion Regulation (CER), and the Experiential-Dynamic Emotion Regulation (EDER) model. Each proposes different views on how emotions are generated, dysregulated and regulated. These perspectives directly influence the way clinicians treat such problems. The CER model views emotional dysregulation as due to a deficit in regulation mechanisms that prioritizes modifying or developing cognitive skills, whilst the EDER model posits emotional dysregulation as due to the presence of dysregulatory mechanisms that prioritizes restoring natural regulatory processes. Examples of relevant techniques for each model are presented including a range of cognitive-behavioral, and experiential (including both dynamic and cognitive) techniques. The aim of the paper is to provide a toolbox from which clinician may gain different techniques to enhance and maintain their patient's capacity for emotional regulation. Finally, the biological mechanisms behind the two models of emotion regulation are discussed as well as a proposal of a dual route model of emotion regulation., (Copyright © 2020 Grecucci, Messina, Amodeo, Lapomarda, Crescentini, Dadomo, Panzeri, Theuninck and Frederickson.)
- Published
- 2020
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46. Women's vulnerability within the childbearing continuum: A scoping review.
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Colciago E, Merazzi B, Panzeri M, Fumagalli S, and Nespoli A
- Abstract
Introduction: The aim of this scoping review is to explore the concept of 'vulnerability' affecting pregnant women and to identify an appropriate definition of this term., Methods: Five stages were adopted for conducting the scoping review. A literature search was undertaken between 1 October 2017 and 5 January 2018, using three databases. Relevant publications were appraised, and semantic content analysis was performed to identify emergent themes and four determinants of the vulnerability concept. This involved combining items that seem to address the same issue., Results: Eleven publications were considered, and eight definitions of vulnerability were identified, and from these four themes emerged: poor health outcome or status; exposure to risk; complex social needs; and lack of resources. Further analysis of evidence found examples of groups of people considered to be vulnerable; they were reported into six matrices, mainly with social and psychological difficulties. From these, eleven themes arose. Following a semantic and content analysis of all themes, thirteen final themes were identified. They represent the characteristics associated with women considered to be vulnerable and are called indices of vulnerability. Semantic and content analysis allowed addressing the thirteen indices of vulnerability into four categories called determinants of the vulnerability concept: deficiency, need, risk exposure, and barriers., Conclusions: The vulnerability could be defined as a lack of health, related to the presence of at least one of the four determinants. Midwives are the key to identify vulnerable women, offering appropriate care., Competing Interests: The authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest and none was reported., (© 2020 Colciago E. et al.)
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- 2020
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47. [Myofascial approach in tension-type headache management: a scientific assessment].
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Panzeri M, Ryvlin P, Staeger P, Gautschi R, and Amstutz V
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- Humans, Pain physiopathology, Tension-Type Headache physiopathology, Trigger Points, Pain Management methods, Tension-Type Headache therapy
- Abstract
Tension-type headaches (TTH) are a very common condition. The most recent theories on TTH occurrences suggest that a myofascial component, through trigger points (TP), gives rise to pain signals from the periphery to the central nervous system (CNS). These nociception could lead to CNS sensitization and headaches. Studies show that identification and treatment of TP is a valid therapeutic option for TTH. Amongst the treatment techniques, dry needling (DN) and ischemic compression (IC) seem to be the most effective. These technics can be easily acquired and applied by any doctor., Competing Interests: Les auteurs n’ont déclaré aucun conflit d’intérêts en relation avec cet article.
- Published
- 2020
48. Percutaneous Microwave Ablation Versus Cryoablation in the Treatment of T1a Renal Tumors.
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De Cobelli F, Papa M, Panzeri M, Colombo M, Steidler S, Ambrosi A, Cao R, Gusmini S, Marra P, Capitanio U, Bertini R, Venturini M, Losa A, Gaboardi F, Montorsi F, and Cardone G
- Subjects
- Adult, Aged, Aged, 80 and over, Cohort Studies, Female, Follow-Up Studies, Humans, Kidney diagnostic imaging, Kidney surgery, Kidney Neoplasms diagnostic imaging, Male, Microwaves, Middle Aged, Retrospective Studies, Tomography, X-Ray Computed, Treatment Outcome, Ablation Techniques methods, Cryosurgery methods, Kidney Neoplasms surgery
- Abstract
Purpose: Radiofrequency and cryoablation (Cryo) are the most widely used techniques for the treatment of T1a renal tumors in non-surgical candidates, yet microwave ablation (MWA) has been gaining popularity. In this study, we tested the hypothesis that MWA has comparable safety and efficacy to Cryo in the treatment of selected T1a renal masses., Materials and Methods: A retrospective comparative analysis of two patient cohorts was carried out on 83 nodules in 72 consecutive patients treated using image-guided percutaneous ablation with either Cryo or MWA. Patient demographics, tumor histology and characteristics, technical success, procedure time, adverse events and complications, nephrometry score (mRENAL) and renal function were evaluated. Local recurrence was evaluated at 1, 6, 12 and 18-24 months., Results: Fifty-one nodules were treated with Cryo and 32 with MWA (44 and 28 patients, respectively). No statistical differences were observed following Cryo or MWA in median tumor size (p = 0.6), mRENAL (p = 0.1) or technical success (p = 0.8). Median procedure time was significantly lower using microwave ablation (p = 0.003). Median follow-up time was similar in the two groups (22 and 20 months, respectively). Occurrence of complications did not differ (Cryo 5/51, MWA 2/32; p = 0.57), and probability of complications or technical success adjusted for mRENAL did not reach statistical significance (p = 0.6). Renal function was preserved in all patients regardless of techniques. Disease recurrence was observed in 3/47 and in 1/30 treated nodules in the Cryo and MWA groups, respectively, without reaching statistical significance (p = 0.06)., Conclusion: In the patient population studied, MWA showed comparable safety and efficacy relative to Cryo., Level of Evidence: Level 3, Non-randomized cohort study.
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- 2020
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49. MRI of acute optic neuritis (ON) at the first episode: Can we predict the visual outcome and the development of multiple sclerosis (MS)?
- Author
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Cellina M, Floridi C, Rosti C, Orsi M, Panzeri M, Pirovano M, Ciocca M, Oliva G, and Gibelli D
- Subjects
- Acute Disease, Adult, Diagnostic Techniques, Ophthalmological, Emergency Service, Hospital, Female, Follow-Up Studies, Humans, Male, Middle Aged, Multiple Sclerosis etiology, Optic Nerve diagnostic imaging, Optic Neuritis drug therapy, Retrospective Studies, Statistics, Nonparametric, Steroids therapeutic use, Time Factors, Tomography, Optical Coherence, Visual Acuity, Young Adult, Brain diagnostic imaging, Magnetic Resonance Imaging, Multiple Sclerosis diagnostic imaging, Optic Neuritis diagnostic imaging
- Abstract
Aim: Our aim was to assess MRI findings in the acute phase of ON and their correlation with visual acuity at presentation, visual outcome (VO) and MS development, to analyze a possible correlation between lesions number and diagnosis, and to assess correlation between orbits MRI and OCT., Materials and Methods: We retrospectively studied 37 patients, who presented to our Emergency Department with an ON first episode from January 2015 to January 2017. Patients underwent immediately a complete neuro-ophthalmological evaluation, blood test, CSF analysis. MRI of brain, orbits, cervical spine was executed within 7 days from ON onset. Brain MRI was classified as: normal, non-specific, suspected demyelination, lesions with dissemination in space and time. Optic nerves findings were localized in three sites (intra-orbital, canalicular and chiasmal) and classified as: normal, STIR- alteration, altered contrast enhancement. Patients underwent neuro-ophthalmological follow-up and MRI at 6 months to assess VO (complete recovery, partial recovery, deficit persistence). Another follow-up at 1 year was performed to identify MS or clinically isolated syndrome (CIS)., Results: 64.8% patients received a diagnosis of MS; 35% of CIS. Lesions of the optic nerve were found in 65.8%. We observed statistically significant correlation between brain MRI pattern and diagnosis and between lesions number and diagnosis. We observed a statistically significant correlation between orbital MRI pattern and optical coherence tomography (OCT) results. MRI brain findings correlate with development of MS. MRI brain features and lesions number can predict the risk of MS conversion.
- Published
- 2019
- Full Text
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50. Prediction of Survival With Long-Term Disease Progression in Most Common Spinocerebellar Ataxia.
- Author
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Diallo A, Jacobi H, Cook A, Giunti P, Parkinson MH, Labrum R, Durr A, Brice A, Charles P, Marelli C, Mariotti C, Nanetti L, Panzeri M, Castaldo A, Rakowicz M, Rola R, Sulek A, Schmitz-Hübsch T, Schöls L, Hengel H, Baliko L, Melegh B, Filla A, Antenora A, Infante J, Berciano J, van de Warrenburg BP, Timmann D, Boesch S, Nachbauer W, Pandolfo M, Schulz JB, Bauer P, Jun-Suk K, Klockgether T, and Tezenas du Montcel S
- Subjects
- Adult, Aged, Cognitive Dysfunction etiology, Cognitive Dysfunction physiopathology, Cohort Studies, Deglutition Disorders etiology, Deglutition Disorders physiopathology, Disease Progression, Dystonia etiology, Dystonia physiopathology, Female, Humans, Longitudinal Studies, Machado-Joseph Disease complications, Machado-Joseph Disease mortality, Machado-Joseph Disease physiopathology, Male, Middle Aged, Prospective Studies, Spinocerebellar Ataxias complications, Survival Rate, Time Factors, Spinocerebellar Ataxias mortality, Spinocerebellar Ataxias physiopathology
- Abstract
Background: Spinocerebellar ataxias are rare dominantly inherited neurodegenerative diseases that lead to severe disability and premature death., Objective: To quantify the impact of disease progression measured by the Scale for the Assessment and Rating of Ataxia on survival, and to identify different profiles of disease progression and survival., Methods: Four hundred sixty-two spinocerebellar ataxia patients from the EUROSCA prospective cohort study, suffering from spinocerebellar ataxia type 1, spinocerebellar ataxia type 2, spinocerebellar ataxia type 3, and spinocerebellar ataxia type 6, and who had at least two measurements of Scale for the Assessment and Rating of Ataxia score, were analyzed. Outcomes were change over time in Scale for the Assessment and Rating of Ataxia score and time to death. Joint model was used to analyze disease progression and survival., Results: Disease progression was the strongest predictor for death in all genotypes: An increase of 1 standard deviation in total Scale for the Assessment and Rating of Ataxia score increased the risk of death by 1.28 times (95% confidence interval: 1.18-1.38) for patients with spinocerebellar ataxia type 1; 1.19 times (1.12-1.26) for spinocerebellar ataxia type 2; 1.30 times (1.19-1.42) for spinocerebellar ataxia type 3; and 1.26 times (1.11-1.43) for spinocerebellar ataxia type 6. Three subgroups of disease progression and survival were identified for patients with spinocerebellar ataxia type 1: "severe" (n = 13; 12%), "intermediate" (n = 31; 29%), and "moderate" (n = 62; 58%). Patients in the severe group were more severely affected at baseline with higher Scale for the Assessment and Rating of Ataxia scores and frequency of nonataxia signs compared to those in the other groups., Conclusion: Rapid ataxia progression is associated with poor survival of the most common spinocerebellar ataxia. Theses current results have implications for the design of future interventional studies of spinocerebellar ataxia. © 2019 International Parkinson and Movement Disorder Society., (© 2019 International Parkinson and Movement Disorder Society.)
- Published
- 2019
- Full Text
- View/download PDF
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